J Allen McCutchan

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Role of obesity, metabolic variables, and diabetes in HIV-associated neurocognitive disorder
    J A McCutchan
    University of California, San Diago, USA
    Neurology 78:485-92. 2012
  2. ncbi HIV-associated neurocognitive disorders in sub-Saharan Africa: a pilot study in Cameroon
    Georgette D Kanmogne
    Department of Pharmacology and Experimental Neurosciences, University of Nebraska Medical Center, Omaha, NE, USA
    BMC Neurol 10:60. 2010
  3. ncbi Management of HIV in resource limited settings
    J Allen McCutchan
    Antiviral Research Center, School of Medicine, University of California, San Diego, California 92105, USA
    Curr Opin Infect Dis 22:464-70. 2009
  4. ncbi Neurocognitive consequences of HIV infection in older adults: an evaluation of the "cortical" hypothesis
    J Cobb Scott
    HIV Neurobehavioral Research Center, Department of Psychiatry, University of California San Diego, San Diego, CA, USA
    AIDS Behav 15:1187-96. 2011
  5. ncbi A randomized, prospective study of phenotype susceptibility testing versus standard of care to manage antiretroviral therapy: CCTG 575
    Richard H Haubrich
    University of California, San Diego, California, USA
    AIDS 19:295-302. 2005
  6. ncbi Clinical factors related to brain structure in HIV: the CHARTER study
    Terry L Jernigan
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive M C 0115, La Jolla, CA, USA
    J Neurovirol 17:248-57. 2011
  7. ncbi Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system
    Scott Letendre
    University of California, San Diego, 150 W Washington St, San Diego, CA 92103, USA
    Arch Neurol 65:65-70. 2008
  8. ncbi Human immunodeficiency virus protease inhibitors and risk for peripheral neuropathy
    Ronald J Ellis
    University of California, San Diego, San Diego, CA, USA
    Ann Neurol 64:566-72. 2008
  9. ncbi CD4 nadir is a predictor of HIV neurocognitive impairment in the era of combination antiretroviral therapy
    Ronald J Ellis
    University of California, San Diego, USA
    AIDS 25:1747-51. 2011
  10. ncbi Longer term improvement in neurocognitive functioning and affective distress among methamphetamine users who achieve stable abstinence
    Jennifer E Iudicello
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92103, USA
    J Clin Exp Neuropsychol 32:704-18. 2010

Research Grants

  1. International NeuroAIDS: Scientific and Methodological Research Challenges
    J McCutchan; Fiscal Year: 2007

Detail Information

Publications82

  1. ncbi Role of obesity, metabolic variables, and diabetes in HIV-associated neurocognitive disorder
    J A McCutchan
    University of California, San Diago, USA
    Neurology 78:485-92. 2012
    ..To evaluate relationships between HIV-associated neurocognitive disorder and metabolic variables in a subgroup of HIV+ participants examined in a prospective, observational, multicenter cohort study...
  2. ncbi HIV-associated neurocognitive disorders in sub-Saharan Africa: a pilot study in Cameroon
    Georgette D Kanmogne
    Department of Pharmacology and Experimental Neurosciences, University of Nebraska Medical Center, Omaha, NE, USA
    BMC Neurol 10:60. 2010
    ..The objectives of this study were to determine whether Western neuropsychological (NP) methods are appropriate for use in Cameroon, and to evaluate cognitive function in a sample of HIV-infected adults...
  3. ncbi Management of HIV in resource limited settings
    J Allen McCutchan
    Antiviral Research Center, School of Medicine, University of California, San Diego, California 92105, USA
    Curr Opin Infect Dis 22:464-70. 2009
    ..5 million persons in RLS from 2002 to the end of 2007 was enabled by the combination of inexpensive rapid diagnostics and therapy for HIV and the mobilization of substantial resources from the developed world...
  4. ncbi Neurocognitive consequences of HIV infection in older adults: an evaluation of the "cortical" hypothesis
    J Cobb Scott
    HIV Neurobehavioral Research Center, Department of Psychiatry, University of California San Diego, San Diego, CA, USA
    AIDS Behav 15:1187-96. 2011
    ..Thus, in this sample of older HIV-infected individuals, the combined effects of HIV and aging do not appear to result in a "cortical" pattern of cognitive deficits...
  5. ncbi A randomized, prospective study of phenotype susceptibility testing versus standard of care to manage antiretroviral therapy: CCTG 575
    Richard H Haubrich
    University of California, San Diego, California, USA
    AIDS 19:295-302. 2005
    ..To assess phenotype susceptibility testing (PHENO) with standard of care (SOC) to improve antiretroviral therapy...
  6. ncbi Clinical factors related to brain structure in HIV: the CHARTER study
    Terry L Jernigan
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive M C 0115, La Jolla, CA, USA
    J Neurovirol 17:248-57. 2011
    ..Brain structural integrity in HIV likely reflects dynamic effects of current immune status and HIV replication, superimposed on residual effects associated with severe prior immunosuppression...
  7. ncbi Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system
    Scott Letendre
    University of California, San Diego, 150 W Washington St, San Diego, CA 92103, USA
    Arch Neurol 65:65-70. 2008
    ..To evaluate whether penetration of a combination regimen into the central nervous system (CNS), as estimated by the CNS Penetration-Effectiveness (CPE) rank, is associated with lower cerebrospinal fluid (CSF) viral load...
  8. ncbi Human immunodeficiency virus protease inhibitors and risk for peripheral neuropathy
    Ronald J Ellis
    University of California, San Diego, San Diego, CA, USA
    Ann Neurol 64:566-72. 2008
    ..Confirmation of peripheral nerve toxicity with PIs could substantially limit their long-term use in highly active ARV therapy...
  9. ncbi CD4 nadir is a predictor of HIV neurocognitive impairment in the era of combination antiretroviral therapy
    Ronald J Ellis
    University of California, San Diego, USA
    AIDS 25:1747-51. 2011
    ..The present study evaluated the probability of neuropsychological impairment (NPI) and HAND as a function of CD4 nadir in an HIV-positive cohort...
  10. ncbi Longer term improvement in neurocognitive functioning and affective distress among methamphetamine users who achieve stable abstinence
    Jennifer E Iudicello
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92103, USA
    J Clin Exp Neuropsychol 32:704-18. 2010
    ..These results suggest partial recovery of neuropsychological functioning and improvement in affective distress upon sustained abstinence from MA that may extend beyond a year or more...
  11. ncbi Demographically corrected norms for African Americans and Caucasians on the Hopkins Verbal Learning Test-Revised, Brief Visuospatial Memory Test-Revised, Stroop Color and Word Test, and Wisconsin Card Sorting Test 64-Card Version
    Marc A Norman
    Department of Psychiatry, University of California, San Diego, CA, USA
    J Clin Exp Neuropsychol 33:793-804. 2011
    ..Findings support the need to consider extended demographic contributions to neuropsychological test performance in clinical and research settings...
  12. ncbi Intraindividual variability in HIV infection: evidence for greater neurocognitive dispersion in older HIV seropositive adults
    Erin E Morgan
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    Neuropsychology 25:645-54. 2011
    ..To our knowledge, no studies have yet examined dispersion in an aging HIV-infected sample...
  13. ncbi Family history of dementia predicts worse neuropsychological functioning among HIV-infected persons
    David J Moore
    Dept of Psychiatry, University of California, San Diego UCSD and the HIV Neurobehavioral Research Center HNRC, UCSD, CA, USA
    J Neuropsychiatry Clin Neurosci 23:316-23. 2011
    ..Thus, FHD appears to be a risk factor for HAND; the mechanism(s) underlying how FHD contributes to NP impairment among HIV+ persons warrants study...
  14. ncbi Prospective memory deficits are associated with unemployment in persons living with HIV infection
    Steven Paul Woods
    Department of Psychiatry, University of California, San Diego, USA
    Rehabil Psychol 56:77-84. 2011
    ..To determine whether deficits in prospective memory (i.e., "remembering to remember") confer an increased risk of unemployment in individuals living with chronic HIV infection...
  15. ncbi Low atazanavir concentrations in cerebrospinal fluid
    Brookie M Best
    Skaggs School of Pharmacy andPharmaceutical Sciences, School of Medicine, Department of Pediatrics, University of California, San Diego, 9500 Gilman Drive, MC 0719, La Jolla, CA 92093 0719, USA
    AIDS 23:83-7. 2009
    ..The objective of this study was to determine atazanavir penetration into cerebrospinal fluid (CSF)...
  16. ncbi Continued high prevalence and adverse clinical impact of human immunodeficiency virus-associated sensory neuropathy in the era of combination antiretroviral therapy: the CHARTER Study
    Ronald J Ellis
    HIV Neurobehavioral Research Center, Department of Neurosciences, University of California, San Diego, San Diego, CA 92103, USA
    Arch Neurol 67:552-8. 2010
    ..To provide updated estimates of the prevalence and clinical impact of human immunodeficiency virus-associated sensory neuropathy (HIV-SN) and neuropathic pain due to HIV-SN in the combination antiretroviral therapy (CART) era...
  17. ncbi The semantic relatedness of cue-intention pairings influences event-based prospective memory failures in older adults with HIV infection
    Steven Paul Woods
    HIV Neurobehavioral Research Center, Department of Psychiatry, University of California, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 32:398-407. 2010
    ....
  18. ncbi Misremembering future intentions in methamphetamine-dependent individuals
    Jennifer E Iudicello
    Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California, San Diego, CA, USA
    Clin Neuropsychol 25:269-86. 2011
    ..Findings suggest that individuals with MA dependence experience difficulty in the strategic components involved in the retrieval of future intentions and are discussed with regard to their implications for everyday functioning...
  19. ncbi A neuropsychological investigation of multitasking in HIV infection: implications for everyday functioning
    J Cobb Scott
    San Diego State University and University of California, San Diego, CA, USA
    Neuropsychology 25:511-9. 2011
    ..The aim of this study was to assess the predictive and ecological validity of a novel multitasking measure in HIV infection...
  20. ncbi Implications of hepatitis C virus infection for behavioral symptoms and activities of daily living
    Carolina Posada
    San Diego State University University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA
    J Clin Exp Neuropsychol 32:637-44. 2010
    ..These results show that a subset of HCV-infected individuals report clinically elevated behavioral symptoms. Clinical implications for the assessment and management of elevated behavioral symptoms in HCV are discussed...
  21. ncbi Relationship of antiretroviral treatment to postmortem brain tissue viral load in human immunodeficiency virus-infected patients
    Dianne Langford
    Department of Pathology, University of California, San Diego, La Jolla, California 92093, USA
    J Neurovirol 12:100-7. 2006
    ..Furthermore, such strategies might help to prevent the development of ARV resistance...
  22. ncbi Psychometric characteristics of the memory for intentions screening test
    Steven Paul Woods
    Department of Psychiatry, University of California, San Diego, CA, USA
    Clin Neuropsychol 22:864-78. 2008
    ..Recommendations are provided regarding future research to enhance the clinical usefulness of the MIST...
  23. ncbi Is prospective memory a dissociable cognitive function in HIV infection?
    Saurabh Gupta
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 32:898-908. 2010
    ..The results of this study lend further evidence to the dissociability of ProM in HIV infection, are consistent with prior studies in healthy adults, and contribute to a growing literature on the construct validity of ProM in HIV disease...
  24. ncbi Normative data and validation of a regression based summary score for assessing meaningful neuropsychological change
    Lucette A Cysique
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California at San Diego, San Diego, CA, USA
    J Clin Exp Neuropsychol 33:505-22. 2011
    ..Correction for practice effects based on normative data improved the consistency of NP impairment classification in a clinically stable longitudinal cohort after baseline...
  25. ncbi White matter tract injury and cognitive impairment in human immunodeficiency virus-infected individuals
    Assawin Gongvatana
    San Diego State University University of California, San Diego, Joint Doctoral Program in Clinical Psychology, San Diego and La Jolla, California, USA
    J Neurovirol 15:187-95. 2009
    ..The study also confirms that CNS injury is evident in persons infected with HIV despite effective antiretroviral treatment...
  26. ncbi Lifetime suicidal ideation and attempt are common among HIV+ individuals
    Jayraan Badiee
    University of California, San Diego, San Diego, CA 92103 8231, United States
    J Affect Disord 136:993-9. 2012
    ..Estimates of the prevalence of lifetime suicidal ideation and attempt, and risks for new-onset suicidality, among HIV-infected (HIV+) individuals are not widely available in the era of modern combined antiretroviral treatment (cART)...
  27. ncbi Cognitive functioning during highly active antiretroviral therapy interruption in human immunodeficiency virus type 1 infection
    Meredith E Childers
    Department of Neurosciences, University of California at San Diego, San Diego, California 92103, USA
    J Neurovirol 14:550-7. 2008
    ..TIs of up to 6 months appear to be neurocognitively and psychiatrically safe for most patients...
  28. ncbi Cognitive mechanisms of switching in HIV-associated category fluency deficits
    Jennifer E Iudicello
    Joint Doctoral Program in Clinical Psychology, San Diego State University, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 30:797-804. 2008
    ..g., mental flexibility), perhaps reflecting underlying neuropathology within prefrontostriatal networks...
  29. ncbi HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors
    Robert K Heaton
    University of California, San Diego, CA, USA
    J Neurovirol 17:3-16. 2011
    ..Clinical trials targeting HAND prevention should specifically examine timing of ART initiation...
  30. ncbi Psychiatric context of human immunodeficiency virus infection among former plasma donors in rural China
    J Hampton Atkinson
    HIV Neurobehavioral Research Center, University of California, San Diego, 220 Dickinson St, San Diego, CA 92103, USA
    J Affect Disord 130:421-8. 2011
    ..Little is known of the psychiatric and substance use disorder characteristics of this population, or their impact on everyday function, employment, and life quality...
  31. ncbi Therapeutic amprenavir concentrations in cerebrospinal fluid
    David Croteau
    Department of Neurosciences, University of California, San Diego, San Diego, California, USA
    Antimicrob Agents Chemother 56:1985-9. 2012
    ..4-fold (IQR, 2.9 to 7.9). We conclude that administration of fosamprenavir should contribute to control of HIV replication in the central nervous system (CNS) as a component of effective antiretroviral regimens...
  32. ncbi Low cerebrospinal fluid concentrations of the nucleotide HIV reverse transcriptase inhibitor, tenofovir
    Brookie M Best
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, CA 92093 0719, USA
    J Acquir Immune Defic Syndr 59:376-81. 2012
    ..The study's objective was to determine tenofovir's penetration into cerebrospinal fluid (CSF)...
  33. ncbi Enhancing antiretroviral therapy for human immunodeficiency virus cognitive disorders
    Scott L Letendre
    HIV Neurobehavioral Research Center, University of California at San Diego, San Diego, CA 92103, USA
    Ann Neurol 56:416-23. 2004
    ..Including CSF-penetrating drugs in the ART regimen and monitoring CSF viral load may be indicated for individuals with HIV-associated cognitive impairment...
  34. ncbi Efavirenz concentrations in CSF exceed IC50 for wild-type HIV
    Brookie M Best
    University of California San Diego, Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, CA, USA
    J Antimicrob Chemother 66:354-7. 2011
    ..This study's objective was to determine penetration of a commonly prescribed antiretroviral drug, efavirenz, into CSF...
  35. ncbi Impairments in fine-motor coordination and speed of information processing predict declines in everyday functioning in hepatitis C infection
    Ofilio Vigil
    Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA 92103, USA
    J Clin Exp Neuropsychol 30:805-15. 2008
    ....
  36. ncbi Predictive validity of demographically adjusted normative standards for the HIV Dementia Scale
    Erin E Morgan
    Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California San Diego, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 30:83-90. 2008
    ..The application of demographically adjusted normative standards on the HDS improves the clinical applicability and accuracy of this cognitive screening measure in the detection of HIV-1-associated neurocognitive disorders...
  37. ncbi Neurobehavioral effects of human immunodeficiency virus infection among former plasma donors in rural China
    Robert K Heaton
    HIV Neurobehavioral Research Center HNRC, Department of Psychiatry, University of California at San Diego, San Diego, California 92093 0603, USA
    J Neurovirol 14:536-49. 2008
    ..These findings indicate that HAND is likely to be an important feature of HIV infection in developing countries, underscoring the need for international efforts to develop CNS-relevant treatments...
  38. ncbi Darunavir is predominantly unbound to protein in cerebrospinal fluid and concentrations exceed the wild-type HIV-1 median 90% inhibitory concentration
    David Croteau
    Department of Neurosciences, University of California San Diego, San Diego, 220 Dickinson Street, Suite B, San Diego, CA 92103, USA
    J Antimicrob Chemother 68:684-9. 2013
    ..Therefore, the objective of this study was to determine total and unbound darunavir concentrations in CSF and compare findings with plasma concentrations as well as the wild-type HIV-1 90% inhibitory concentration (IC(90))...
  39. ncbi Increased accumulation of intraneuronal amyloid beta in HIV-infected patients
    Cristian L Achim
    Department of Psychiatry, University of California, San Diego, CA 92093 0624, USA
    J Neuroimmune Pharmacol 4:190-9. 2009
    ..These findings suggest that long-term survival with HIV might interfere with clearance of proteins such as Abeta and worsen neuronal damage and cognitive impairment in this population...
  40. ncbi HIV suppression by HAART preserves cognitive function in advanced, immune-reconstituted AIDS patients
    J Allen McCutchan
    University of California San Diego, 150 West Washington Street, San Diego, CA 92103, USA
    AIDS 21:1109-17. 2007
    ..Epidemiological observations suggest that neuropsychological impairment might progress despite successful HAART therapy, but available prevalence estimates are based on populations that were selected for impairment...
  41. ncbi A randomized controlled trial of therapeutic drug monitoring in treatment-naive and -experienced HIV-1-infected patients
    Brookie M Best
    University of California, San Diego, San Diego, CA 92013, USA
    J Acquir Immune Defic Syndr 46:433-42. 2007
    ..To improve the utility of therapeutic drug monitoring (TDM) by defining the proportion of patients with and predictors of above or below target protease inhibitor (PI) or nonnucleoside reverse transcriptase inhibitor (NNRTI) concentrations...
  42. ncbi HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study
    R K Heaton
    University of California, San Diego, USA
    Neurology 75:2087-96. 2010
    ....
  43. ncbi Neurologic complications of HIV disease and their treatment
    Scott L Letendre
    HIV Neurobehavioral Research Center, University of California San Diego, San Diego, CA, USA
    Top HIV Med 18:45-55. 2010
    ..The extensive data presented will inform new research and clinical decisions in the coming year...
  44. ncbi Neurocognitive functioning in acute or early HIV infection
    David J Moore
    Department of Psychiatry, University of California, San Diego UCSD, San Diego, CA, USA
    J Neurovirol 17:50-7. 2011
    ..Although a significant monotonic trend existed and patterns of the data suggest the AEH individuals may fall intermediate to HIV- and chronic participants, we were not able to statistically confirm this hypothesis...
  45. ncbi Population pharmacokinetics of abacavir in plasma and cerebrospinal fluid
    Edmund V Capparelli
    Pediatric Pharmacology Research Unit PPRU, University of California, San Diego, 200 West Arbor Drive, MC 8214, San Diego, CA 92103 8214, USA
    Antimicrob Agents Chemother 49:2504-6. 2005
    ..The abacavir CSF/plasma ratio averaged 36% and increased throughout the dose interval. Abacavir penetrates into the CSF in adequate concentrations to inhibit local human immunodeficiency virus replication...
  46. ncbi Prospective memory in HIV infection: is "remembering to remember" a unique predictor of self-reported medication management?
    Steven Paul Woods
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92093, USA
    Arch Clin Neuropsychol 23:257-70. 2008
    ..The potential benefits of individualized remediation strategies that are informed by conceptual models of ProM and specifically target medication adherence warrant further exploration...
  47. ncbi Human immunodeficiency virus-1 RNA levels in cerebrospinal fluid exhibit a set point in clinically stable patients not receiving antiretroviral therapy
    Ronald J Ellis
    Department of Neurosciences and HIV Neurobehavioral Research Center, University of California San Diego, San Diego, CA 92103, USA
    J Infect Dis 187:1818-21. 2003
    ....
  48. ncbi Variable patterns of neuropsychological performance in HIV-1 infection
    S Dawes
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California San Diego, San Diego, CA 92093 0603, USA
    J Clin Exp Neuropsychol 30:613-26. 2008
    ..Thus, there does not appear to be a single, prototypical pattern of neuropsychological impairment associated with HIV infection for this battery of representative neuropsychological tests...
  49. ncbi Highlights of the 15th Conference on Retroviruses and Opportunistic Infections. Neurologic complications of HIV disease and their treatment
    Scott Letendre
    Department of Medicine, Division of Infectious Diseases, University of California San Diego, San Diego, CA, USA
    Top HIV Med 16:15-22. 2008
    ....
  50. ncbi Hypertriglyceridemia in combination antiretroviral-treated HIV-positive individuals: potential impact on HIV sensory polyneuropathy
    Sugato Banerjee
    Department of Neurosciences, USA bDepartment of Medicine, University of California, San Diego, California 92103 8231, USA
    AIDS 25:F1-6. 2011
    ..Elevated serum triglycerides (TRGs) are associated with an increased risk for sensory neuropathy in diabetes mellitus. However, the contribution of hTRG to sensory neuropathy in HIV has not been carefully evaluated...
  51. ncbi Etravirine in CSF is highly protein bound
    Anh Nguyen
    Department of Pediatrics Rady Children s Hospital, University of California San Diego, 3020 Childrens Way, San Diego, CA 92123, USA
    J Antimicrob Chemother 68:1161-8. 2013
    ..The objective of this study was to compare total and unbound etravirine concentrations in CSF with plasma concentrations and the in vitro median inhibitory concentration (IC50) for wild-type HIV (0.9 ng/mL)...
  52. ncbi Two-year prospective study of major depressive disorder in HIV-infected men
    J Hampton Atkinson
    Department of Psychiatry, University of California San Diego, School of Medicine, La Jolla, California 92093, USA
    J Affect Disord 108:225-34. 2008
    ..This 2-year prospective study compared cumulative rates and predictors of a major depressive episode in HIV-infected (HIV+) men (N=297) and uninfected (HIV-) risk-group controls (N=90)...
  53. ncbi The correlation between plasma concentrations of protease inhibitors, medication adherence and virological outcome in HIV-infected patients
    Julie M Yasuda
    San Diego State University, San Diego, Calif, USA
    Antivir Ther 9:753-61. 2004
    ..CONCLUSIONS: Repeated, random PI concentration values are independently predictive of virological response and may add to self-report of adherence in understanding the response to ART...
  54. ncbi Progression to neuropsychological impairment in human immunodeficiency virus infection predicted by elevated cerebrospinal fluid levels of human immunodeficiency virus RNA
    Ronald J Ellis
    HIV Neurobehavioral Research Center, University of California, San Diego, 150 W Washington St, 2nd Floor, San Diego, CA 92103, USA
    Arch Neurol 59:923-8. 2002
    ....
  55. ncbi Meeting practical challenges of a trial involving a multitude of treatment regimens: an example of a multi-center randomized controlled clinical trial in neuroAIDS
    Susanne May
    Division of Biostatistics and Bioinformatics, Department of Family and Preventive Medicine, and Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive M C 0717, La Jolla, CA 92093 0717, USA
    J Neuroimmune Pharmacol 2:97-104. 2007
    ..A small pilot study demonstrated the feasibility and acceptability to providers. In conclusion, an innovative design can provide solutions to challenging practical issues in trials with multiple treatment options...
  56. ncbi Correlation of in vivo neuroimaging abnormalities with postmortem human immunodeficiency virus encephalitis and dendritic loss
    Sarah L Archibald
    Department of Psychiatry, University of California, San Diego, and Veterans Affairs San Diego Healthcare System, La Jolla, 92093, USA
    Arch Neurol 61:369-76. 2004
    ..Although previous studies have linked brain viral levels to these alterations, other neuropathological mechanisms might also contribute to them...
  57. ncbi The clinical relevance of non-nucleoside reverse transcriptase inhibitor hypersusceptibility: a prospective cohort analysis
    Richard H Haubrich
    University of California at San Diego, San Diego, California, USA
    AIDS 16:F33-40. 2002
    ..1). CONCLUSION: NNRTI hypersusceptibility occurred in more than 20% of nucleoside-experienced patients and was associated with greater reduction of HIV RNA and increase in CD4 cells...
  58. ncbi Fluconazole alone or combined with flucytosine for the treatment of AIDS-associated cryptococcal meningitis
    Eric Milefchik
    University of Southern California, San Diego, California, USA
    Med Mycol 46:393-5. 2008
    ..Addition of flucytosine to fluconazole improved outcomes in each dosing cohort. High doses of fluconazole alone or combined with flucytosine were well tolerated...
  59. ncbi The role of cohort studies in drug development: clinical evidence of antiviral activity of serotonin reuptake inhibitors and HMG-CoA reductase inhibitors in the central nervous system
    Scott L Letendre
    University of California, 150 W Washington St, San Diego, CA 92103, USA
    J Neuroimmune Pharmacol 2:120-7. 2007
    ..Some of these drugs, such as serotonin reuptake inhibitors (SRIs) and HMG-CoA reductase inhibitors (statins), may do so by reducing HIV replication in the CNS and are already widely used by HIV-infected individuals...
  60. ncbi Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder
    Erick T Tatro
    Department of Psychiatry 0603, University of California at San Diego, La Jolla, San Diego, CA 92093 0603, USA
    J Neuroimmune Pharmacol 4:218-26. 2009
    ..Instead, an increase in FKBP51 at both the transcript (FKBP5) and protein level correlated with MDD. Increased FKBP4 expression of correlated to HIV(+)MDD but not to HIV without MDD...
  61. ncbi Brain mitochondrial injury in human immunodeficiency virus-seropositive (HIV+) individuals taking nucleoside reverse transcriptase inhibitors
    Brian C Schweinsburg
    VA San Diego Healthcare System, San Diego, California 92103, USA
    J Neurovirol 11:356-64. 2005
    ..Measurement of brain metabolites sensitive to impairments in energy metabolism, including NAA, may aid in early detection of subclinical NRTI-mediated mitochondrial toxicity...
  62. ncbi Spontaneous strategy use protects against visual working memory deficits in older adults infected with HIV
    Steven Paul Woods
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Clin Neuropsychol 25:724-33. 2010
    ....
  63. ncbi Cytochrome P450-2D6 extensive metabolizers are more vulnerable to methamphetamine-associated neurocognitive impairment: preliminary findings
    Mariana Cherner
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0847, USA
    J Int Neuropsychol Soc 16:890-901. 2010
    ..This preliminary study is the first to suggest that efficient meth metabolism is associated with worse neurocognitive outcomes in humans, and implicates the products of oxidative metabolism of meth as a possible source of brain injury...
  64. ncbi Prediction of incident neurocognitive impairment by plasma HIV RNA and CD4 levels early after HIV seroconversion
    Thomas D Marcotte
    Department of Psychiatry, University of California San Diego, 92103, USA
    Arch Neurol 60:1406-12. 2003
    ..Neuropsychological (NP) impairment is a relatively common sequela in human immunodeficiency virus (HIV)-infected individuals with advanced disease. Early antecedents of NP dysfunction, however, remain poorly understood...
  65. ncbi Psychiatric context of acute/early HIV infection. The NIMH Multisite Acute HIV Infection Study: IV
    J Hampton Atkinson
    HIV Neurobehavioral Research Center, University of California of San Diego, La Jolla, CA, 92103, USA
    AIDS Behav 13:1061-7. 2009
    ..The psychiatric context of acute/early HIV infection may be a precursor to infection, but not necessarily a barrier to intervention to reduce forward transmission of HIV among persons newly infected...
  66. ncbi Pleocytosis is associated with disruption of HIV compartmentalization between blood and cerebral spinal fluid viral populations
    Davey M Smith
    University of California San Diego, La Jolla, 92093, USA
    Virology 385:204-8. 2009
    ....
  67. ncbi The effects of hepatitis C, HIV, and methamphetamine dependence on neuropsychological performance: biological correlates of disease
    Scott L Letendre
    Department of Medicine, University of California San Diego, CA 92103, USA
    AIDS 19:S72-8. 2005
    ..To determine the effects of hepatitis C virus (HCV) infection on neuropsychological (NP) performance...
  68. ncbi Unmasking of PML by HAART: unusual clinical features and the role of IRIS
    Navdeesh Sidhu
    Owen Clinic, Antiviral Research Center, and HIV Neurobehavioral Research Center, University of California, San Diego, La Jolla, CA, United States
    J Neuroimmunol 219:100-4. 2010
    ..Only 3 of the 8 patients with unmasked PML had IRIS reactions as evidenced by contrast enhancement around lesions on MRI, suggesting that IRIS is not necessary for the pathogenesis of this syndrome...
  69. ncbi Incidence of and risk factors for clinically significant methicillin-resistant Staphylococcus aureus infection in a cohort of HIV-infected adults
    Wm Christopher Mathews
    Department of Medicine, University of California, San Diego, Owen Clinic, UCSD Medical Center, San Diego, CA 92103, USA
    J Acquir Immune Defic Syndr 40:155-60. 2005
    ..This study's purpose was to estimate trends in the incidence of and risk factors for clinically significant MRSA (CS-MRSA) infection in a cohort of HIV-infected adults...
  70. ncbi Severe, demyelinating leukoencephalopathy in AIDS patients on antiretroviral therapy
    T Dianne Langford
    Department of Pathology, University of California, San Diego, CA, USA
    AIDS 16:1019-29. 2002
    ..This condition warrants further study and increased vigilance among those who provide care for HIV-infected individuals...
  71. ncbi A double-blinded, randomized controlled trial of zoledronate therapy for HIV-associated osteopenia and osteoporosis
    Jeannie Huang
    Department of Pediatrics, University of California, San Diego, La Jolla, California 92103, USA
    AIDS 23:51-7. 2009
    ..To evaluate the efficacy of a single dose of intravenous zoledronate for the treatment of HIV-associated osteopenia and osteoporosis...
  72. ncbi Genetic attributes of cerebrospinal fluid-derived HIV-1 env
    Satish K Pillai
    University of California San Diego, Department of Medicine NCIRE, La Jolla, CA 94121, USA
    Brain 129:1872-83. 2006
    ..Furthermore, neurological impairment may be influenced by mutations within the viral V3 loop sequence...
  73. ncbi Safety and immunogenicity of hepatitis A vaccine in human immunodeficiency virus-infected patients: a double-blind, randomized, placebo-controlled trial
    Carol A Kemper
    Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, San Jose, California, USA
    J Infect Dis 187:1327-31. 2003
    ..004). HepA vaccine was well tolerated and had no effect on the course of HIV infection or plasma HIV RNA load...
  74. ncbi Patterns of selective neuronal damage in methamphetamine-user AIDS patients
    Dianne Langford
    Department of Pathology, University of California at San Francisco, La Jolla, CA 92093-0624, USA
    J Acquir Immune Defic Syndr 34:467-74. 2003
    ..In combination, METH and HIV may increase neuronal cell injury and death, thereby enhancing brain metabolic disturbances observed in clinical populations of HIV-positive METH abusers...
  75. ncbi Incomplete immune reconstitution after initiation of highly active antiretroviral therapy in human immunodeficiency virus-infected patients with severe CD4+ cell depletion
    Howard M Lederman
    Eudowood Division of Pediatric Allergy and Immunology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Infect Dis 188:1794-803. 2003
    ..009) and mumps skin test antigen (29% vs. 17%; P=.001). Although the subjects had only partial responses to immune function testing, the rate of opportunistic infections was very low, and none of the tests was predictive of risk...
  76. ncbi Symptom-based framework for assessing quality of HIV care
    Steven M Asch
    Department of General Internal Medicine, VA Greater Los Angeles Health System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Int J Qual Health Care 16:41-50. 2004
    ..To evaluate HIV quality of care using a symptom-based, patient-centered framework...
  77. ncbi The impact of HIV-associated neuropsychological impairment on everyday functioning
    Robert K Heaton
    Department of Psychiatry, University of California at San Diego, and VA San Diego Health Care System, La Jolla, 92093-0603, USA
    J Int Neuropsychol Soc 10:317-31. 2004
    ..Finally, there is a need for additional research investigating the apparently independent effect of depression on level of everyday functioning in HIV infected persons...
  78. ncbi The relationship between AIDS retinal cotton wool spots and neuropsychological impairment in HIV-positive individuals in the pre-highly active antiretroviral therapy era
    William R Freeman
    Department of Ophthalmology, Shiley Eye Center, University of California-San Diego, La Jolla, CA 92093, USA
    Ocul Immunol Inflamm 12:25-33. 2004
    ....
  79. ncbi Long-term follow-up of HIV-infected individuals who have significant increases in CD4+ cell counts during antiretroviral therapy
    Susan L Koletar
    Division of Infectious Diseases, Ohio State University, Columbus, OH 43210, USA
    Clin Infect Dis 39:1500-6. 2004
    ..Descriptions of the durability and consequences of immune reconstitution in patients who start highly active antiretroviral therapy (HAART) while severely immunosuppressed are limited...
  80. ncbi Use of and adherence to antiretroviral therapy is associated with decreased sexual risk behavior in HIV clinic patients
    Catherine Diamond
    University of California Irvine Medical Center, Department of Internal Medicine, Orange, CA, USA
    J Acquir Immune Defic Syndr 39:211-8. 2005
    ..6 (95% CI 0.5-0.8, P < 0.001). Contrary to expectations, use of and adherence to ART and their consequent suppression of HIV were associated with a decreased prevalence of self-reported risky sexual behavior...
  81. ncbi Relationship of CSF leukocytosis to compartmentalized changes in MCP-1/CCL2 in the CSF of HIV-infected patients undergoing interruption of antiretroviral therapy
    Sergio Monteiro de Almeida
    Alameda Princesa Izabel 1223/AP51, Curitiba-PR CEP, Brazil
    J Neuroimmunol 179:180-5. 2006
    ..Both initial MCP-1 levels and subsequent changes were 3-fold larger in CSF than plasma. The magnitude and timing of changes suggested that MCP-1 triggers the development of CSF pleocytosis...
  82. ncbi Measuring medication: do interviews agree with medical record and pharmacy data?
    P Todd Korthuis
    Greater Los Angeles VA Health Care System, UCLA, Building 500, Room 3233, 11301 Wilshire Boulevard 111G, Los Angeles, CA 90073, USA
    Med Care 40:1270-82. 2002
    ..Medication measurement is crucial in assessing quality for chronic conditions yet agreement of alternate data sources remains uncertain...

Research Grants5

  1. International NeuroAIDS: Scientific and Methodological Research Challenges
    J McCutchan; Fiscal Year: 2007
    ....