Christopher McCurdy

Summary

Affiliation: University of Mississippi
Country: USA

Publications

  1. ncbi request reprint Analgesic substances derived from natural products (natureceuticals)
    Christopher R McCurdy
    Department of Medicinal Chemistry, School of Pharmacy, National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS 38677, USA
    Life Sci 78:476-84. 2005
  2. ncbi request reprint Antinociceptive profile of salvinorin A, a structurally unique kappa opioid receptor agonist
    Christopher R McCurdy
    Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Pharmacol Biochem Behav 83:109-13. 2006
  3. ncbi request reprint p-Hydroxyphenylpyruvate dioxygenase is a herbicidal target site for beta-triketones from Leptospermum scoparium
    Franck E Dayan
    United States Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, P O Box 8048, University, MS 38677, USA
    Phytochemistry 68:2004-14. 2007
  4. doi request reprint Beta-triketone inhibitors of plant p-hydroxyphenylpyruvate dioxygenase: modeling and comparative molecular field analysis of their interactions
    Franck E Dayan
    US Department of Agriculture, Natural Products Utilization Research Unit, Agricultural Research Service, University, Mississippi 38677, USA
    J Agric Food Chem 57:5194-200. 2009
  5. ncbi request reprint A combined ligand-based and target-based drug design approach for G-protein coupled receptors: application to salvinorin A, a selective kappa opioid receptor agonist
    Nidhi Singh
    Department of Medicinal Chemistry and Laboratory for Applied Drug Design and Synthesis, The University of Mississippi, University, MS 38677, USA
    J Comput Aided Mol Des 20:471-93. 2006
  6. ncbi request reprint Specific cross-linking of Lys233 and Cys235 in the mu opioid receptor by a reporter affinity label
    Yan Zhang
    Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biochemistry 44:2271-5. 2005
  7. ncbi request reprint Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) enzyme
    Nidhi Singh
    Department of Medicinal Chemistry and Laboratory for Applied Drug Design and Synthesis, School of Pharmacy, University of Mississippi, University, MS 38677 1848, USA
    Curr Pharm Des 13:1161-77. 2007
  8. ncbi request reprint Opioid receptor-like 1 (ORL1) molecular "road map" to understanding ligand interaction and selectivity
    Ashok E Philip
    Department of Medicinal Chemistry, School of Pharmacy, Faser 419, The University of Mississippi, University, MS 38677, USA
    Curr Top Med Chem 5:325-40. 2005
  9. ncbi request reprint Sigma receptors and cocaine abuse
    Sanju Narayanan
    Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, 38677, USA
    Curr Top Med Chem 11:1128-50. 2011
  10. ncbi request reprint Mitragyna speciosa, a psychoactive tree from Southeast Asia with opioid activity
    Jessica E Adkins
    Department of Medicinal Chemistry, Laboratory for Applied Drug Design and Synthesis, School of Pharmacy, The University of Mississippi, University, 38677, USA
    Curr Top Med Chem 11:1165-75. 2011

Research Grants

  1. Salvinorin A: A Structurally Novel Opioid Agonist Lead
    Christopher McCurdy; Fiscal Year: 2004
  2. Novel Pharmacologic Interventions for Drugs of Abuse
    Christopher McCurdy; Fiscal Year: 2007
  3. Novel Pharmacologic Interventions for Drugs of Abuse
    Christopher R McCurdy; Fiscal Year: 2010

Collaborators

  • Yan Zhang
  • K J Sufka
  • PHILIP PORTOGHESE
  • Franck E Dayan
  • Stephen O Duke
  • Nigel B Perry
  • Edward Boyer
  • Kavita M Babu
  • Nidhi Singh
  • Brian E Kane
  • Jessica E Adkins
  • David M Ferguson
  • Ashok E Philip
  • Sanju Narayanan
  • Francisco Leon
  • Jacques H Poupaert
  • Catherine B Willmore-Fordham
  • Sarika Prabhu Haris
  • Mitchell A Avery
  • Jason E Warnick
  • Werner J Geldenhuys
  • Christophe Mesangeau
  • Stephen J Cutler
  • Eman Habib
  • Edward B Furr
  • Tammy L Nolan
  • Bertrand Le Bourdonnec
  • David H Kinder
  • Daniel M Krall
  • Gweneal Chevé
  • Gwénaël Chevé
  • Marcelo J Nieto
  • David D Allen
  • James H McAfee
  • Bryan L Miller
  • Paul R Lockman

Detail Information

Publications22

  1. ncbi request reprint Analgesic substances derived from natural products (natureceuticals)
    Christopher R McCurdy
    Department of Medicinal Chemistry, School of Pharmacy, National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS 38677, USA
    Life Sci 78:476-84. 2005
    ..e., no side effects, no addictive potential), natural products still hold great promise for the future of drug discovery especially in the treatment of pain disorders and potentially drug addictions...
  2. ncbi request reprint Antinociceptive profile of salvinorin A, a structurally unique kappa opioid receptor agonist
    Christopher R McCurdy
    Department of Medicinal Chemistry, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Pharmacol Biochem Behav 83:109-13. 2006
    ..These findings demonstrate that salvinorin A produces a KOP mediated antinociceptive effect with a short duration of action...
  3. ncbi request reprint p-Hydroxyphenylpyruvate dioxygenase is a herbicidal target site for beta-triketones from Leptospermum scoparium
    Franck E Dayan
    United States Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, P O Box 8048, University, MS 38677, USA
    Phytochemistry 68:2004-14. 2007
    ..Computational analysis of the catalytic domain of HPPD indicates that a lipophilic domain proximate from the Fe2+ favors the binding of ligands with lipophilic moieties...
  4. doi request reprint Beta-triketone inhibitors of plant p-hydroxyphenylpyruvate dioxygenase: modeling and comparative molecular field analysis of their interactions
    Franck E Dayan
    US Department of Agriculture, Natural Products Utilization Research Unit, Agricultural Research Service, University, Mississippi 38677, USA
    J Agric Food Chem 57:5194-200. 2009
    ....
  5. ncbi request reprint A combined ligand-based and target-based drug design approach for G-protein coupled receptors: application to salvinorin A, a selective kappa opioid receptor agonist
    Nidhi Singh
    Department of Medicinal Chemistry and Laboratory for Applied Drug Design and Synthesis, The University of Mississippi, University, MS 38677, USA
    J Comput Aided Mol Des 20:471-93. 2006
    ....
  6. ncbi request reprint Specific cross-linking of Lys233 and Cys235 in the mu opioid receptor by a reporter affinity label
    Yan Zhang
    Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Biochemistry 44:2271-5. 2005
    ..The combined utilization of a reporter affinity label and site-directed mutagenesis offers a more expeditious method of identifying cross-linking at a recognition site when compared to classical procedures...
  7. ncbi request reprint Targeting the methyl erythritol phosphate (MEP) pathway for novel antimalarial, antibacterial and herbicidal drug discovery: inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) enzyme
    Nidhi Singh
    Department of Medicinal Chemistry and Laboratory for Applied Drug Design and Synthesis, School of Pharmacy, University of Mississippi, University, MS 38677 1848, USA
    Curr Pharm Des 13:1161-77. 2007
    ....
  8. ncbi request reprint Opioid receptor-like 1 (ORL1) molecular "road map" to understanding ligand interaction and selectivity
    Ashok E Philip
    Department of Medicinal Chemistry, School of Pharmacy, Faser 419, The University of Mississippi, University, MS 38677, USA
    Curr Top Med Chem 5:325-40. 2005
    ....
  9. ncbi request reprint Sigma receptors and cocaine abuse
    Sanju Narayanan
    Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, 38677, USA
    Curr Top Med Chem 11:1128-50. 2011
    ..Although there is still a lack of an agent in clinical trials with a sigma receptor mechanism of action, work is progressing and the ligands are becoming more selective for sigma systems and the potential remains high...
  10. ncbi request reprint Mitragyna speciosa, a psychoactive tree from Southeast Asia with opioid activity
    Jessica E Adkins
    Department of Medicinal Chemistry, Laboratory for Applied Drug Design and Synthesis, School of Pharmacy, The University of Mississippi, University, 38677, USA
    Curr Top Med Chem 11:1165-75. 2011
    ..In addition to the pharmacological studies, two total syntheses of mitragynine have been published as well as general structure-activity relationships (SARs) with respect to opioid activity...
  11. doi request reprint Chemical function-based pharmacophore development for novel, selective kappa opioid receptor agonists
    Nidhi Singh
    Department of Medicinal Chemistry, Laboratory for Applied Drug Design and Synthesis, The University of Mississippi, Mississippi 38677, USA
    J Mol Graph Model 27:131-9. 2008
    ..It is anticipated that such an approach will lead to the generation of novel selective KOP agonists that are clinically useful for the treatment of pain through peripheral mechanisms...
  12. ncbi request reprint Inhibition of choline uptake by N-cyclohexylcholine, a high affinity ligand for the choline transporter at the blood-brain barrier
    Werner J Geldenhuys
    Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Science Centre, Amarillo, TX 79106, USA
    J Drug Target 13:259-66. 2005
    ..Taken together, the results of these in situ and in silico studies provide further evidence or restrictions that occur with binding to this brain drug delivery vector...
  13. ncbi request reprint o-Naphthalenedicarboxaldehyde derivative of 7'-aminonaltrindole as a selective delta-opioid receptor affinity label
    Sarika Prabhu Haris
    Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Med Chem 50:3392-6. 2007
    ..Molecular simulation studies suggest that compound 1 may form a Schiff base with the epsilon-amino group of Lys214, which could explain its irreversibility and transformation into a delta-agonist through a conformational change of TM5...
  14. ncbi request reprint Opioid receptor function in social attachment in young domestic fowl
    Jason E Warnick
    Department of Psychology, University of Mississippi, University, 38677, USA
    Behav Brain Res 160:277-85. 2005
    ..Further, the non-selective opiate antagonist naloxone (0.3, 8.3, 27.5 nmol) did not exacerbate distress vocalizations. These results suggest that only the mu receptor modulates social attachment in young domestic fowl...
  15. ncbi request reprint Toward Mycobacterium tuberculosis DXR inhibitor design: homology modeling and molecular dynamics simulations
    Nidhi Singh
    Department of Medicinal Chemistry, Laboratory for Applied Drug Design and Synthesis, University of Mississippi, University, MS, 38677 1848, USA
    J Comput Aided Mol Des 21:511-22. 2007
    ....
  16. ncbi request reprint Phytochemical characterization of the leaves of Mitragyna speciosa grown in U.S.A
    Francisco Leon
    Department of Medicinal Chemistry and National Center for Natural Products Research, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Nat Prod Commun 4:907-10. 2009
    ..This is the first report of the last group of compounds having been isolated from a Mitragyna species. Biological studies are currently underway to test these compounds for opioid activity...
  17. pmc Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth)
    Edward W Boyer
    Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Addiction 103:1048-50. 2008
    ..Kratom (Mitragynia speciosa korth) is recognized increasingly as a remedy for opioid withdrawal by individuals who self-treat chronic pain...
  18. ncbi request reprint A unique binding epitope for salvinorin A, a non-nitrogenous kappa opioid receptor agonist
    Brian E Kane
    Department of Medicinal Chemistry and Center for Drug Design, University of Minnesota, MN 55455, USA
    FEBS J 273:1966-74. 2006
    ..The ligand is also in close proximity to EL-2 which, based on chimeric data, is proposed to play an indirect role in salvinorin A binding and selectivity...
  19. doi request reprint Toward a structure-based model of salvinorin A recognition of the kappa-opioid receptor
    Brian E Kane
    Department of Medicinal Chemistry and Center for Drug Design, University of Minnesota, Minneapolis, MN 55455, USA
    J Med Chem 51:1824-30. 2008
    ..The model explains the role that hydrophobic contacts play in binding this lipophilic ligand and gives insight into the structural basis to the mu-opioid receptor selectivity of 2'-benzoyl salvinorin (herkinorin)...
  20. doi request reprint Opioid receptors and legal highs: Salvia divinorum and Kratom
    Kavita M Babu
    Division of Medical Toxicology, Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Clin Toxicol (Phila) 46:146-52. 2008
    ..The purpose of this article is to familiarize toxicologists and poison control specialists with these emerging psychoactive dietary supplements...
  21. ncbi request reprint The hallucinogen derived from Salvia divinorum, salvinorin A, has kappa-opioid agonist discriminative stimulus effects in rats
    Catherine B Willmore-Fordham
    Ohio Northern University, Department of Pharmaceutical and Biomedical Sciences, Raabe College of Pharmacy, 525 S Main Street, Ada, OH 45810, USA
    Neuropharmacology 53:481-6. 2007
    ..The discussion section of this article highlights public concern over salvinorin A misuse and emphasizes several potential pharmacotherapeutic applications for salvinorin A or analogue compounds...

Research Grants5

  1. Salvinorin A: A Structurally Novel Opioid Agonist Lead
    Christopher McCurdy; Fiscal Year: 2004
    ..Results of this work will direct further analog development of Salvinorin A (a next generation) and further define and refine our proposed computer binding and field models. ..
  2. Novel Pharmacologic Interventions for Drugs of Abuse
    Christopher McCurdy; Fiscal Year: 2007
    ..4) To demonstrate the novel compounds attenuate cocaine-induced behaviors. ..
  3. Novel Pharmacologic Interventions for Drugs of Abuse
    Christopher R McCurdy; Fiscal Year: 2010
    ..4) To demonstrate the novel compounds attenuate cocaine-induced behaviors. ..