J M McCune

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint IFN-alpha secretion by type 2 predendritic cells up-regulates MHC class I in the HIV-1-infected thymus
    Mary E Keir
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 168:325-31. 2002
  2. ncbi request reprint The dynamics of CD4+ T-cell depletion in HIV disease
    J M McCune
    Gladstone Institute of Virology and Immunology, Departments of Medicine and Microbiology and Immunology, University of California at San Francisco, 94141 9100, USA
    Nature 410:974-9. 2001
  3. pmc Factors influencing T-cell turnover in HIV-1-seropositive patients
    J M McCune
    The Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, California 94141, USA
    J Clin Invest 105:R1-8. 2000
  4. ncbi request reprint Cytomegalovirus (CMV)-specific CD4+ T lymphocyte immune function in long-term survivors of AIDS-related CMV end-organ disease who are receiving potent antiretroviral therapy
    M A Jacobson
    University of California San Francisco, Department of Medicine, Ward 84, 995 Potrero St, San Francisco, CA 94110, USA
    J Infect Dis 183:1399-404. 2001
  5. pmc High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection
    J M McCune
    The Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, California 94141 9100, USA
    J Clin Invest 101:2301-8. 1998
  6. ncbi request reprint Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia
    S G Deeks
    University of California, San Francisco, and San Francisco General Hospital, USA
    N Engl J Med 344:472-80. 2001
  7. ncbi request reprint Direct measurement of CD4+ and CD8+ T-cell responses to CMV in HIV-1-infected subjects
    K V Komanduri
    Gladstone Institute of Virology and Immunology, San Francisco, California 94141-9100, USA
    Virology 279:459-70. 2001
  8. ncbi request reprint Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis
    L A Napolitano
    Gladstone Institute of Virology and Immunology, San Francisco General Hospital, and Department of Medicine, University of California at San Francisco, San Francisco, California 94110-9100, USA
    Nat Med 7:73-9. 2001
  9. pmc Antiviral activity of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice
    C A Stoddart
    Antiviral Drug Research Division, Gladstone Institute of Virology and Immunology, San Francisco, California, USA
    Antimicrob Agents Chemother 44:783-6. 2000
  10. pmc Inhibition of human immunodeficiency virus type 1 infection in SCID-hu Thy/Liv mice by the G-quartet-forming oligonucleotide, ISIS 5320
    C A Stoddart
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, USA
    Antimicrob Agents Chemother 42:2113-5. 1998

Detail Information

Publications68

  1. ncbi request reprint IFN-alpha secretion by type 2 predendritic cells up-regulates MHC class I in the HIV-1-infected thymus
    Mary E Keir
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 168:325-31. 2002
    ..Furthermore, thymic preDC2 are permissive for HIV-1 infection and positive for intracellular p24. These data demonstrate the ability of IFN-alpha secreted by preDC2 to induce MHC I up-regulation in the HIV-1-infected human thymus...
  2. ncbi request reprint The dynamics of CD4+ T-cell depletion in HIV disease
    J M McCune
    Gladstone Institute of Virology and Immunology, Departments of Medicine and Microbiology and Immunology, University of California at San Francisco, 94141 9100, USA
    Nature 410:974-9. 2001
    ..Ironically, this failure may be precipitated by physiological mechanisms designed to maintain homeostasis in the face of accelerated T-cell loss...
  3. pmc Factors influencing T-cell turnover in HIV-1-seropositive patients
    J M McCune
    The Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, California 94141, USA
    J Clin Invest 105:R1-8. 2000
    ..Such interpatient variation in T-cell kinetics may be reflective of differences in functional immune reconstitution after treatment for HIV-1 disease...
  4. ncbi request reprint Cytomegalovirus (CMV)-specific CD4+ T lymphocyte immune function in long-term survivors of AIDS-related CMV end-organ disease who are receiving potent antiretroviral therapy
    M A Jacobson
    University of California San Francisco, Department of Medicine, Ward 84, 995 Potrero St, San Francisco, CA 94110, USA
    J Infect Dis 183:1399-404. 2001
    ..However, 6 of these 10 subjects also had negative CMV-specific immune responses > or =1 time. Such patients may be at risk for future CMV disease progression and should be closely monitored...
  5. pmc High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection
    J M McCune
    The Gladstone Institute of Virology and Immunology, University of California, San Francisco, San Francisco, California 94141 9100, USA
    J Clin Invest 101:2301-8. 1998
    ..03). These studies suggest that the thymus is functional in some but not all adults with HIV-1 disease...
  6. ncbi request reprint Virologic and immunologic consequences of discontinuing combination antiretroviral-drug therapy in HIV-infected patients with detectable viremia
    S G Deeks
    University of California, San Francisco, and San Francisco General Hospital, USA
    N Engl J Med 344:472-80. 2001
    ..In many patients with human immunodeficiency virus (HIV) infection, therapy with potent antiretroviral drugs does not result in complete suppression of HIV replication. The effect of cessation of therapy in these patients is unknown...
  7. ncbi request reprint Direct measurement of CD4+ and CD8+ T-cell responses to CMV in HIV-1-infected subjects
    K V Komanduri
    Gladstone Institute of Virology and Immunology, San Francisco, California 94141-9100, USA
    Virology 279:459-70. 2001
    ..These declines may precede the onset of CMV-associated end organ disease...
  8. ncbi request reprint Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis
    L A Napolitano
    Gladstone Institute of Virology and Immunology, San Francisco General Hospital, and Department of Medicine, University of California at San Francisco, San Francisco, California 94110-9100, USA
    Nat Med 7:73-9. 2001
    ..We propose that IL-7 production increases as part of a homeostatic response to T-cell depletion...
  9. pmc Antiviral activity of 2'-deoxy-3'-oxa-4'-thiocytidine (BCH-10652) against lamivudine-resistant human immunodeficiency virus type 1 in SCID-hu Thy/Liv mice
    C A Stoddart
    Antiviral Drug Research Division, Gladstone Institute of Virology and Immunology, San Francisco, California, USA
    Antimicrob Agents Chemother 44:783-6. 2000
    ..These experiments demonstrate the utility of this mouse model for evaluating drug resistance and for performing direct comparisons between antiviral compounds in vivo...
  10. pmc Inhibition of human immunodeficiency virus type 1 infection in SCID-hu Thy/Liv mice by the G-quartet-forming oligonucleotide, ISIS 5320
    C A Stoddart
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California, USA
    Antimicrob Agents Chemother 42:2113-5. 1998
    ..Potent in vivo antiviral activity was observed against the T-cell-tropic molecular clone NL4-3; the agent was found to have weak activity against one primary HIV-1 isolate, and the agent was inactive against a second primary isolate...
  11. ncbi request reprint Impaired replication of protease inhibitor-resistant HIV-1 in human thymus
    C A Stoddart
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, California, USA
    Nat Med 7:712-8. 2001
    ..We propose that the inability of PI-resistant HIV-1 to replicate efficiently in thymus contributes to the preservation of CD4+ T-cell counts in patients showing virologic rebound on PI therapy...
  12. ncbi request reprint Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trial
    Donald I Abrams
    University of California, San Francisco, and Gladstone Institute of Virology and Immunology, San Francisco, California 94110, USA
    Ann Intern Med 139:258-66. 2003
    ..Cannabinoid use could potentially alter HIV RNA levels by two mechanisms: immune modulation or cannabinoid-protease inhibitor interactions (because both share cytochrome P-450 metabolic pathways)...
  13. pmc Central memory CD8+ T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression
    Kristin Ladell
    Division of Experimental Medicine and Department of Medicine, University of California, San Francisco, CA 94110, USA
    J Immunol 180:7907-18. 2008
    ....
  14. pmc Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease
    David Favre
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, CA 94110, USA
    Sci Transl Med 2:32ra36. 2010
    ..We postulate that induction of IDO may represent a critical initiating event that results in inversion of the T(H)17/T(reg) balance and in the consequent maintenance of a chronic inflammatory state in progressive HIV disease...
  15. pmc HIV-induced changes in T cell signaling pathways
    Marc Schweneker
    Division of Experimental Medicine, University of California, San Francisco, CA 94110, USA
    J Immunol 180:6490-500. 2008
    ....
  16. pmc Loss of T cell responses following long-term cryopreservation
    Rachel E Owen
    Blood Systems Research Institute, 270 Masonic Avenue, San Francisco, CA 94118, USA
    J Immunol Methods 326:93-115. 2007
    ..Long-term cryopreservation, however, may lead to the loss of CD4(+) T cell responses and mild skewing of T cell phenotypic marker expression...
  17. ncbi request reprint Loss of cytomegalovirus-specific CD4+ T cell responses in human immunodeficiency virus type 1-infected patients with high CD4+ T cell counts and recurrent retinitis
    K V Komanduri
    Gladstone Institute of Virology and Immunology, Department of Medicine, University of California, San Francisco, CA, USA
    J Infect Dis 183:1285-9. 2001
    ....
  18. pmc Cytomegalovirus-specific T cells persist at very high levels during long-term antiretroviral treatment of HIV disease
    David M Naeger
    Department of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e8886. 2010
    ..The impact of untreated and treated HIV infection on the frequency of these cells remains undefined...
  19. ncbi request reprint Multiparameter evaluation of human thymic function: interpretations and caveats
    Jeffrey M Harris
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, CA 94103, USA
    Clin Immunol 115:138-46. 2005
    ..These data illustrate the complex relationship between these measures of thymic size and function and underscore the need to develop more definitive measures of thymic function in the future...
  20. pmc Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy
    Peter W Hunt
    Positive Health Program, San Francisco General Hospital, Bldg 80, Ward 84, 995 Potrero Ave, San Francisco, CA 94110, USA
    J Infect Dis 197:126-33. 2008
    ....
  21. ncbi request reprint Prevalence of CXCR4 tropism among antiretroviral-treated HIV-1-infected patients with detectable viremia
    Peter W Hunt
    Positive Health Program, San Francisco General Hospital, San Francisco, CA 94110, USA
    J Infect Dis 194:926-30. 2006
    ..CCR5 inhibitors may thus be best strategically used before salvage therapy and before significant CD4 + T cell depletion...
  22. pmc Growth hormone enhances thymic function in HIV-1-infected adults
    Laura A Napolitano
    Gladstone Institute of Virology and Immunology, San Francisco, California 94158, USA
    J Clin Invest 118:1085-98. 2008
    ..Further, these randomized, prospective data have shown that thymic involution can be pharmacologically reversed in humans, suggesting that immune-based therapies could be used to enhance thymopoiesis in immunodeficient individuals...
  23. ncbi request reprint Dehydroepiandrosterone (DHEA) effects on HIV replication and host immunity: a randomized placebo-controlled study
    Donald I Abrams
    Community Consortium, Positive Health Program, University of California, San Francisco, CA 94143, USA
    AIDS Res Hum Retroviruses 23:77-85. 2007
    ....
  24. ncbi request reprint Increased carotid intima-media thickness in HIV patients is associated with increased cytomegalovirus-specific T-cell responses
    Priscilla Y Hsue
    Divisions of Cardiology, San Francisco General Hospital, University of California, San Francisco, USA
    AIDS 20:2275-83. 2006
    ....
  25. pmc Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy
    Hiroyu Hatano
    San Francisco General Hospital, Building 80, Ward 84, 995 Potrero Avenue, San Francisco, CA 94110, USA
    J Virol 83:329-35. 2009
    ..This confirms the failure to eradicate the virus, even in these unique individuals who are able to reduce plasma viremia to very low levels without antiretroviral therapy...
  26. pmc Suberoylanilide hydroxamic acid reactivates HIV from latently infected cells
    Xavier Contreras
    Department of Medicine, University of California, San Francisco, California 94143, USA
    J Biol Chem 284:6782-9. 2009
    ..Thus SAHA, which is a Food and Drug Administration-approved drug, might be considered to accelerate the decay of the latent reservoir in HAART-treated infected humans...
  27. pmc Persistent systemic inflammation and atypical enterocolitis in patients with NEMO syndrome
    Laurence E Cheng
    Department of Pediatrics, University of California, San Francisco School of Medicine, San Francisco, CA 94143, USA
    Clin Immunol 132:124-31. 2009
    ..Our data suggest that some patients with the NEMO syndrome exhibit persistent elevation of inflammatory markers similar to systemic autoimmune diseases and may subsequently develop an atypical enterocolitis...
  28. pmc IFN-alpha-induced upregulation of CCR5 leads to expanded HIV tropism in vivo
    Cheryl A Stoddart
    Division of Experimental Medicine, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, San Francisco, California, USA
    PLoS Pathog 6:e1000766. 2010
    ..These observations suggest a mechanism by which IFN-alpha production may paradoxically expand the tropism of R5 HIV and, in so doing, accelerate disease progression...
  29. pmc Expression of the autoimmune susceptibility gene FcRL3 on human regulatory T cells is associated with dysfunction and high levels of programmed cell death-1
    Louise A Swainson
    Division of Experimental Medicine, Department of Medicine, University of California at San Francisco, San Francisco, CA 94110, USA
    J Immunol 184:3639-47. 2010
    ..These data suggest that FcRL3 expression is associated with T(reg) dysfunction that may, in turn, contribute to the loss of self-tolerance and the development of autoimmunity...
  30. pmc Design, construction, and validation of a modular library of sequence diversity standards for polymerase chain reaction
    Paul D Baum
    University of California, San Francisco, CA 94143, USA
    Anal Biochem 411:106-15. 2011
    ..These standards should greatly improve the accuracy and reproducibility of sequence diversity measurements...
  31. pmc HIV-specific CD4+ T cells may contribute to viral persistence in HIV controllers
    Peter W Hunt
    Department of Medicine, University of California, San Francisco, California, USA
    Clin Infect Dis 52:681-7. 2011
    ..Despite robust immune responses, these individuals never eradicate HIV infection. We hypothesized that HIV-specific CD4(+) T cells might serve as target cells for HIV, contributing to viral persistence in this setting...
  32. pmc A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers
    Peter W Hunt
    Departments of Medicine and Laboratory Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 6:e15924. 2011
    ..These data support a model in which low frequencies of Tregs in HIV controllers may contribute to an effective adaptive immune response, but may also contribute to generalized immune activation, potentially contributing to CD4 depletion...
  33. pmc Neutralizing antibody responses against autologous and heterologous viruses in acute versus chronic human immunodeficiency virus (HIV) infection: evidence for a constraint on the ability of HIV to completely evade neutralizing antibody responses
    Steven G Deeks
    Department of Medicine, University of California at San Francisco, San Francisco General Hospital, CA 94110, USA
    J Virol 80:6155-64. 2006
    ..These observations also suggest that the neutralizing antibody response may contribute to the long-term control of HIV in some patients while protecting against HIV superinfection in most patients...
  34. pmc Increased circulating interleukin-7 levels in HIV-1-infected women
    Laura A Napolitano
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, 94158, USA
    J Acquir Immune Defic Syndr 40:581-4. 2005
    ..0032) after controlling for CD4 count, age, and race. Given the important role of IL-7 in T-cell development and homeostasis, these findings suggest that higher IL-7 levels may contribute to higher CD4 counts in women...
  35. ncbi request reprint Strong cell-mediated immune responses are associated with the maintenance of low-level viremia in antiretroviral-treated individuals with drug-resistant human immunodeficiency virus type 1
    Steven G Deeks
    Department of Medicine, University of California, San Francisco, San Francisco, California, USA
    J Infect Dis 189:312-21. 2004
    ..Collectively, these data suggest that the selection of drug-resistance mutations may reduce the pathogenic potential of HIV, which leads to a balanced state of enhanced cellular immunity and low-level viremia...
  36. ncbi request reprint Effects of IL-7 on early human thymocyte progenitor cells in vitro and in SCID-hu Thy/Liv mice
    Laura A Napolitano
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, CA 94141, USA
    J Immunol 171:645-54. 2003
    ..Given the growing interest in the use of IL-7 for the treatment of human immunodeficiency, these findings support additional investigation into its in vivo effects on thymopoiesis and HIV infection...
  37. ncbi request reprint CD4+ T cell kinetics and activation in human immunodeficiency virus-infected patients who remain viremic despite long-term treatment with protease inhibitor-based therapy
    Steven G Deeks
    Department of Medicine, University of California at San Francisco and San Francisco General Hospital, San Francisco, CA 94110, USA
    J Infect Dis 185:315-23. 2002
    ..These data indicate that partial virus suppression reduces CD4(+) cell turnover and activation, thereby resulting in sustained CD4(+) cell gains, and that measurements of T cell dynamics may provide an in vivo marker of viral virulence...
  38. ncbi request reprint Enhanced replication of R5 HIV-1 over X4 HIV-1 in CD4(+)CCR5(+)CXCR4(+) T cells
    Ann Marie Roy
    Gladstone Institute of Virology and Immunology, 1650 Owens Street, San Francisco, CA 94158, USA
    J Acquir Immune Defic Syndr 40:267-75. 2005
    ..This replicative advantage may contribute to the predominance of R5 HIV-1 in vivo...
  39. ncbi request reprint Comparison of the ELISPOT and cytokine flow cytometry assays for the enumeration of antigen-specific T cells
    Annika C Karlsson
    Gladstone Institute of Virology and Immunology, University of California San Francisco, P O Box 419100, San Francisco, CA 94141 9100, USA
    J Immunol Methods 283:141-53. 2003
    ..In contrast, the CFC has a greater dynamic range and allows for phenotypic discrimination of responding cells, making it the assay of choice for most other applications...
  40. ncbi request reprint Growth hormone-induced stimulation of multilineage human hematopoiesis
    Mary B Hanley
    Gladstone Institute of Virology and Immunology, 1650 Owens Street, San Francisco, California 94158 2261, USA
    Stem Cells 23:1170-9. 2005
    ..These findings identify specific targets of GH and IGF-I within human FBM, and demonstrate direct and indirect effects that may contribute to GH-mediated enhancement of human hemato-lymphopoiesis...
  41. pmc Variations in the heme oxygenase-1 microsatellite polymorphism are associated with plasma CD14 and viral load in HIV-infected African-Americans
    L Seu
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94110, USA
    Genes Immun 13:258-67. 2012
    ..04). These data demonstrate that the HO-1 GT(n) microsatellite polymorphism is associated with higher levels of HO-1 expression and that this pathway may have important effects on the association between inflammation and HIV replication...
  42. pmc HLA class I-restricted T-cell responses may contribute to the control of human immunodeficiency virus infection, but such responses are not always necessary for long-term virus control
    Brinda Emu
    Positive Health Program, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
    J Virol 82:5398-407. 2008
    ..Defining mechanisms for virus control in "non-T-cell controllers" might lead to insights into preventing HIV transmission or preventing virus replication...
  43. pmc Suppression of SIV-specific CD4+ T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression
    Kristina Abel
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 204:2679-92. 2007
    ..In aggregate, these observations suggest that the T reg cell compartment of the infant macaque facilitates rapid disease progression, at least in part by incapacitating SIV-specific CD4(+) T cell responses...
  44. ncbi request reprint Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells
    DENNIS J HARTIGAN-O'CONNOR
    Division of Experimental Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Immunol Methods 319:41-52. 2007
    ..This surface phenotype should allow for quantitative studies of regulatory T cells in disease states as well as for enrichment of live regulatory T cells for functional analyses and/or expansion in vitro...
  45. pmc Naive human T cells are activated and proliferate in response to the heme oxygenase-1 inhibitor tin mesoporphyrin
    Trevor D Burt
    Division of Neonatology, Department of Pediatrics, University of California San Francisco, San Francisco, CA 94110, USA
    J Immunol 185:5279-88. 2010
    ..Based on these findings, we propose a potential role for HO-1 in the control of naive T cell homeostatic proliferation...
  46. ncbi request reprint Increased thymic mass and circulating naive CD4 T cells in HIV-1-infected adults treated with growth hormone
    Laura A Napolitano
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, CA 94141, USA
    AIDS 16:1103-11. 2002
    ..To determine whether treatment with growth hormone (GH) enhances thymopoiesis in individuals infected with HIV-1...
  47. ncbi request reprint A membrane-bound Fas decoy receptor expressed by human thymocytes
    M Jenkins
    Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94141 9100, USA
    J Biol Chem 275:7988-93. 2000
    ....
  48. ncbi request reprint Gene expression profiles during human CD4+ T cell differentiation
    Myeong Sup Lee
    Gladstone Institute of Virology and Immunology, University of California at San Francisco, San Francisco, CA 94141, USA
    Int Immunol 16:1109-24. 2004
    ..Further evaluation of these findings may lead to a better definition of human thymopoiesis as well as to improved approaches to monitor and to augment the function of this important organ of T cell production...
  49. pmc Maternal alloantigens promote the development of tolerogenic fetal regulatory T cells in utero
    Jeff E Mold
    Division of Experimental Medicine, Department of Medicine, University of California at San Francisco UCSF, San Francisco, CA 94110, USA
    Science 322:1562-5. 2008
    ..These findings reveal a form of antigen-specific tolerance in humans, induced in utero and probably active in regulating immune responses after birth...
  50. pmc Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4/epsilon4 genotype accelerates HIV disease progression
    Trevor D Burt
    Division of Experimental Medicine, Department of Medicine, and Division of Neonatology, Department of Pediatrics, University of California, San Francisco, CA 94110, USA
    Proc Natl Acad Sci U S A 105:8718-23. 2008
    ....
  51. ncbi request reprint HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes
    M E Roland
    University of California, San Francisco, CA, USA
    Am J Transplant 8:355-65. 2008
    ....
  52. pmc Th17 and regulatory T cells: implications for AIDS pathogenesis
    Bittoo Kanwar
    Division of Experimental Medicine, Department of Medicine, University of California San Francisco, CA 94110, USA
    Curr Opin HIV AIDS 5:151-7. 2010
    ....
  53. pmc Human immunodeficiency virus type 1 Nef-mediated downregulation of CD4 correlates with Nef enhancement of viral pathogenesis
    Cheryl A Stoddart
    Gladstone Institute of Virology and Immunology Departments of Medicine Microbiology and Immunology, University of California, San Francisco, California 94141, USA
    J Virol 77:2124-33. 2003
    ..Nef-mediated CD4 downregulation merits consideration as a new target for the development of small-molecule inhibitors...
  54. pmc The role of transplacental microtransfusions of maternal lymphocytes in in utero HIV transmission
    Tzong Hae Lee
    Blood Systems Research Institute, San Francisco, CA, USA
    J Acquir Immune Defic Syndr 55:143-7. 2010
    ..The mechanisms of HIV transmission from mothers to infants are poorly understood. A possible mechanism of in utero transmission is transplacental transfer of HIV-infected maternal leukocytes into the fetal circulation during pregnancy...
  55. pmc In vivo imaging of mucosal CD4+ T cells using single photon emission computed tomography in a murine model of colitis
    Bittoo Kanwar
    Department of Medicine, Division of Experimental Medicine, The University of California, San Francisco, San Francisco, CA 94143 1234, USA
    J Immunol Methods 329:21-30. 2008
    ..This approach should be readily applicable to the imaging of discrete cell subpopulations in non-human primates and in humans, thus augmenting our understanding of infectious diseases and inflammation in vivo...
  56. pmc Cytotrophoblast induction of arterial apoptosis and lymphangiogenesis in an in vivo model of human placentation
    Kristy Red-Horse
    Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, California, USA
    J Clin Invest 116:2643-52. 2006
    ....
  57. ncbi request reprint HIV tropism and CD4+ T-cell depletion
    Mark B Feinberg
    Nat Med 8:537. 2002
  58. ncbi request reprint Generation of CD3+CD8low thymocytes in the HIV type 1-infected thymus
    Mary E Keir
    Biomedical Sciences Graduate Program, University of California, San Francisco 94143, USA
    J Immunol 169:2788-96. 2002
    ..We suggest that this HIV-1-initiated selection process may contribute to the generation of dysfunctional CD8(+) T cells in HIV-1-infected patients...
  59. ncbi request reprint Short-term effects of cannabinoids on immune phenotype and function in HIV-1-infected patients
    Barry M Bredt
    Department of Medicine, General Clinical Research Center at San Francisco General Hospital, CA 94110, USA
    J Clin Pharmacol 42:82S-89S. 2002
    ..On the basis of these measurements and during this short 21-day study period, few statistically significant effects were noted on immune system phenotypes orfunctions in this patient population...
  60. pmc Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection
    Marc K Hellerstein
    University of California, Berkeley, 119 Morgan Hall, Berkeley, California 94720 3104, USA
    J Clin Invest 112:956-66. 2003
    ..The greatest impact of advanced HIV-1 infection is to reduce the generation of long-lived, potential progenitor T cells...
  61. ncbi request reprint HIV-1-specific CD4+ T cell responses in chronically HIV-1 infected blippers on antiretroviral therapy in relation to viral replication following treatment interruption
    Emmanouil Papasavvas
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    J Clin Immunol 26:40-54. 2006
    ..04) with no difference between groups by week 24. These data support that blippers have higher anti-HIV lymphoproliferative responses while on ART but experience equal to higher viral rebound as compared to matched non-blippers upon TI...
  62. ncbi request reprint Isolation of peripheral blood CD4(+) T cells using RosetteSep and MACS for studies of DNA turnover by deuterium labeling
    Robert Busch
    KineMed, Inc, 5980 Horton St, Emeryville, CA 94608, USA
    J Immunol Methods 286:97-109. 2004
    ..Thus, both FACS and the new method isolate a similar mixture of long- and short-lived CD4(+) T cells. In practice, the RosetteSep/MACS method is simple, rapid, robust and capable of high throughput...
  63. pmc Effect of SIVmac infection on plasmacytoid and CD1c+ myeloid dendritic cells in cynomolgus macaques
    Benoit Malleret
    CEA, Service d Immuno Virologie, DSV iMETI, IPSC, Fontenay aux Roses, France
    Immunology 124:223-33. 2008
    ..Information regarding absolute pDC and mDC counts in non-human primates may improve our understanding of the role of these cells in SIV/HIV infection and in other infectious diseases...
  64. ncbi request reprint Long-term changes in circulating CD4 T lymphocytes in virologically suppressed patients after 6 years of highly active antiretroviral therapy
    Kimberly Smith
    Department of Infectious Diseases, Rush Medical College of Rush University, Chicago, IL 60612, USA
    AIDS 18:1953-6. 2004
    ..This cohort represents the longest prospective immunological follow-up of virologically suppressed patients on HAART...
  65. pmc Antiviral antibodies are necessary for control of simian immunodeficiency virus replication
    Christopher J Miller
    Center for Comparative Medicine, California National Primate Research Center, University of California, Davis, Davis, California 95616, USA
    J Virol 81:5024-35. 2007
    ..0001). These observations indicate that antiviral antibody responses are critical in maintaining effective control of SIV replication at early time points postinfection...
  66. pmc Phenotypic, functional, and kinetic parameters associated with apparent T-cell control of human immunodeficiency virus replication in individuals with and without antiretroviral treatment
    Brinda Emu
    Department of Medicine, San Francisco General Hospital, University of California, 94110, USA
    J Virol 79:14169-78. 2005
    ....
  67. ncbi request reprint A plea for justice for jailed medical workers
    Sunil K Ahuja
    Science 314:924-5. 2006
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