Robert E McCullumsmith

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. doi request reprint Novel approaches to the study of postmortem brain in psychiatric illness: old limitations and new challenges
    Robert E McCullumsmith
    Department of Psychiatry and Behavioral Neurobiology, Universityof Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294, USA
    Biol Psychiatry 69:127-33. 2011
  2. pmc Expression of transcripts for myelination-related genes in the anterior cingulate cortex in schizophrenia
    Robert E McCullumsmith
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA
    Schizophr Res 90:15-27. 2007
  3. pmc Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder
    Robert E McCullumsmith
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, CIRC 576A 0021, 1530 3rd Avenue South, Birmingham, AL 35294, USA
    Brain Res 1127:108-18. 2007
  4. pmc Abnormal expression of glutamate transporters in temporal lobe areas in elderly patients with schizophrenia
    Dan Shan
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Schizophr Res 144:1-8. 2013
  5. pmc Regional differences in expression of β-tubulin isoforms in schizophrenia
    Mark S Moehle
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, United States
    Schizophr Res 135:181-6. 2012
  6. pmc Abnormal activity of the MAPK- and cAMP-associated signaling pathways in frontal cortical areas in postmortem brain in schizophrenia
    Adam J Funk
    Department of Neurobiology, University of Alabama Birmingham, Birmingham, AL 35294 0021, USA
    Neuropsychopharmacology 37:896-905. 2012
  7. doi request reprint Vesicular glutamate transporter mRNA expression in the medial temporal lobe in major depressive disorder, bipolar disorder, and schizophrenia
    Akihito Uezato
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
    Bipolar Disord 11:711-25. 2009
  8. pmc Expression of four housekeeping proteins in elderly patients with schizophrenia
    Deborah Elaine Bauer
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, SC560, 1530 3rd Ave S, Birmingham, AL, 35294 0017, USA
    J Neural Transm 116:487-91. 2009
  9. pmc Abnormal glycosylation of EAAT1 and EAAT2 in prefrontal cortex of elderly patients with schizophrenia
    Deborah Bauer
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Schizophr Res 117:92-8. 2010
  10. pmc Decreased expression of NMDA receptor-associated proteins in frontal cortex of elderly patients with schizophrenia
    Adam J Funk
    Departments of aNeurobiology bPsychiatry and Behavioral Neurobiology, University of Alabama, Birmingham, Alabama, USA
    Neuroreport 20:1019-22. 2009

Research Grants

  1. Glutamate Transporter Expression in Schizophrenia
    Robert McCullumsmith; Fiscal Year: 2007

Collaborators

Detail Information

Publications29

  1. doi request reprint Novel approaches to the study of postmortem brain in psychiatric illness: old limitations and new challenges
    Robert E McCullumsmith
    Department of Psychiatry and Behavioral Neurobiology, Universityof Alabama at Birmingham School of Medicine, Birmingham, Alabama 35294, USA
    Biol Psychiatry 69:127-33. 2011
    ..These techniques will permit scientists working in the postmortem field to ask and answer the largest possible questions, providing new targets for drug discovery and improved treatments for severe mental illness...
  2. pmc Expression of transcripts for myelination-related genes in the anterior cingulate cortex in schizophrenia
    Robert E McCullumsmith
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA
    Schizophr Res 90:15-27. 2007
    ..Our results support the hypothesis that myelination and oligodendrocyte function are impaired in schizophrenia...
  3. pmc Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder
    Robert E McCullumsmith
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, CIRC 576A 0021, 1530 3rd Avenue South, Birmingham, AL 35294, USA
    Brain Res 1127:108-18. 2007
    ..In the present work, we focus on the expression of these molecules in hippocampus in schizophrenia and bipolar affective disorder I...
  4. pmc Abnormal expression of glutamate transporters in temporal lobe areas in elderly patients with schizophrenia
    Dan Shan
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Schizophr Res 144:1-8. 2013
    ..Our findings suggest that buffering and reuptake, but not presynaptic release, of glutamate is altered in glutamate synapses in the temporal lobe in schizophrenia...
  5. pmc Regional differences in expression of β-tubulin isoforms in schizophrenia
    Mark S Moehle
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, United States
    Schizophr Res 135:181-6. 2012
    ..Our data supports the growing body of evidence suggesting abnormalities of the cytoskeleton in schizophrenia...
  6. pmc Abnormal activity of the MAPK- and cAMP-associated signaling pathways in frontal cortical areas in postmortem brain in schizophrenia
    Adam J Funk
    Department of Neurobiology, University of Alabama Birmingham, Birmingham, AL 35294 0021, USA
    Neuropsychopharmacology 37:896-905. 2012
    ..Together with previous findings, these data suggest that abnormalities of intracellular signaling pathways may contribute to the pathophysiology of schizophrenia...
  7. doi request reprint Vesicular glutamate transporter mRNA expression in the medial temporal lobe in major depressive disorder, bipolar disorder, and schizophrenia
    Akihito Uezato
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
    Bipolar Disord 11:711-25. 2009
    ..We investigated this presynaptic marker in major psychiatric illness by measuring transcript expression of the VGLUTs in the medial temporal lobe...
  8. pmc Expression of four housekeeping proteins in elderly patients with schizophrenia
    Deborah Elaine Bauer
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, SC560, 1530 3rd Ave S, Birmingham, AL, 35294 0017, USA
    J Neural Transm 116:487-91. 2009
    ..We did not detect any differences in expression between subjects with schizophrenia and a comparison group. These results suggest that all four proteins are suitable loading controls for postmortem studies of schizophrenia...
  9. pmc Abnormal glycosylation of EAAT1 and EAAT2 in prefrontal cortex of elderly patients with schizophrenia
    Deborah Bauer
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Schizophr Res 117:92-8. 2010
    ..Our data suggest an abnormality of posttranslational modification of glutamate transporters in schizophrenia that suggests a decreased capacity for glutamate reuptake...
  10. pmc Decreased expression of NMDA receptor-associated proteins in frontal cortex of elderly patients with schizophrenia
    Adam J Funk
    Departments of aNeurobiology bPsychiatry and Behavioral Neurobiology, University of Alabama, Birmingham, Alabama, USA
    Neuroreport 20:1019-22. 2009
    ..These data suggest that NMDA receptor complex formation, localization, and downstream signaling may be abnormal in schizophrenia...
  11. pmc Expression of equilibrative nucleoside transporter type 1 protein in elderly patients with schizophrenia
    Dan Shan
    Department of Psychiatry and Behavioral Neurobiology, School of Medicine, Civitan International Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Neuroreport 23:224-7. 2012
    ..We found decreased ENT1 expression in the STG in patients with schizophrenia, supporting the hypothesis of altered glutamate transport in this illness...
  12. pmc Gene expression of glutamate metabolizing enzymes in the hippocampal formation in human temporal lobe epilepsy
    Tore Eid
    Departments of Laboratory Medicine Psychiatry Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520 8035, USA
    Epilepsia 54:228-38. 2013
    ..However, the molecular mechanism of the enzyme perturbations remains unclear. A better understanding of the regulatory mechanisms of GS and PAG could facilitate the discovery of novel therapeutics for TLE...
  13. pmc Recent advances in targeting the ionotropic glutamate receptors in treating schizophrenia
    Robert E McCullumsmith
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
    Curr Pharm Biotechnol 13:1535-42. 2012
    ..In this article, we review drugs that modulate ionotropic gluamate receptors and discuss their efficacy for the treatment of this often debilitating severe mental illness...
  14. pmc Abnormal expression of glutamate transporter and transporter interacting molecules in prefrontal cortex in elderly patients with schizophrenia
    Deborah Bauer
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, United States
    Schizophr Res 104:108-20. 2008
    ..These data indicate that proteins involved in glutamate reuptake and cycling are altered in the cortex in schizophrenia, and may provide potential targets for future treatment strategies...
  15. pmc Endosomal trafficking of AMPA receptors in frontal cortex of elderly patients with schizophrenia
    John C Hammond
    Department of Neurobiology, University of Alabama Birmingham, Birmingham, AL 35294 0021, United States
    Schizophr Res 130:260-5. 2011
    ..1, NEEP21, GRASP1, liprin α, and syntaxin13). Together, these data suggest that endosomal trafficking of AMPA receptors in the prefrontal cortex may be largely intact in schizophrenia...
  16. pmc Evidence for abnormal forward trafficking of AMPA receptors in frontal cortex of elderly patients with schizophrenia
    John C Hammond
    Department of Neurobiology, University of Alabama Birmingham, 35294 0021, USA
    Neuropsychopharmacology 35:2110-9. 2010
    ..Together, these data suggest that there is an alteration of forward trafficking of AMPA receptors as well as changes in the subcellular localization of an AMPA receptor subunit in schizophrenia...
  17. pmc Abnormal N-linked glycosylation of cortical AMPA receptor subunits in schizophrenia
    Janusz Tucholski
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 0017, USA
    Schizophr Res 146:177-83. 2013
    ..Altered N-linked glycosylation of the GluR2 subunit in schizophrenia suggests abnormal trafficking of AMPA receptors from the ER to the synaptic membrane in schizophrenia...
  18. pmc Cortical expression of glial fibrillary acidic protein and glutamine synthetase is decreased in schizophrenia
    Amy E Steffek
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109 2200, United States
    Schizophr Res 103:71-82. 2008
    ....
  19. pmc Altered vesicular glutamate transporter expression in the anterior cingulate cortex in schizophrenia
    Akin Oni-Orisan
    Wayne State University School of Medicine, Detroit, Michigan, USA
    Biol Psychiatry 63:766-75. 2008
    ..Recent studies have shown that VGLUTs regulate synaptic activity via the amount of glutamate released. Accordingly, we hypothesized that VGLUTs are altered in schizophrenia, contributing to dysfunction of presynaptic activity...
  20. ncbi request reprint Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders
    Monica Beneyto
    Department of Psychiatry, University of Pittsburgh, 3801 O Hara Street, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 32:1888-902. 2007
    ..We propose that disturbances in glutamate-mediated synaptic transmission in the medial temporal lobe are important factors in the pathophysiology of these severe psychiatric illnesses...
  21. ncbi request reprint Expression of excitatory amino acid transporter interacting protein transcripts in the thalamus in schizophrenia
    Ibone Huerta
    Molecular and Behavioral Neuroscience Institute and Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Synapse 59:394-402. 2006
    ..These findings suggest that proteins associated with the regulation of glutamate reuptake may be abnormal in this illness, supporting the hypothesis of altered thalamic glutamatergic neurotransmission in schizophrenia...
  22. ncbi request reprint Differential effects of antipsychotics on haloperidol-induced vacuous chewing movements and subcortical gene expression in the rat
    Robert E McCullumsmith
    Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Eur J Pharmacol 477:101-12. 2003
    ..Changes in expression of other transcripts were not detected. These findings demonstrate important differences in the effects of typical and atypical antipsychotics on chronic vacuous chewing movements...
  23. ncbi request reprint Molecular abnormalities of the glutamate synapse in the thalamus in schizophrenia
    James H Meador-Woodruff
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    Ann N Y Acad Sci 1003:75-93. 2003
    ..Our data suggest that schizophrenia is associated with abnormal glutamate receptor-related intracellular signaling in the thalamus, and point to novel targets for innovative drug discovery...
  24. ncbi request reprint Expression of ARHGEF11 mRNA in schizophrenic thalamus
    Genoveva Davidkova
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Ann N Y Acad Sci 1003:375-7. 2003
  25. ncbi request reprint Expression of transcripts for the vesicular glutamate transporters in the human medial temporal lobe
    Robert E McCullumsmith
    Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109 0720, USA
    Ann N Y Acad Sci 1003:438-42. 2003
  26. ncbi request reprint Schizophrenia as a disorder of neuroplasticity
    Robert E McCullumsmith
    Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Int Rev Neurobiol 59:19-45. 2004
    ..We suggest that schizophrenia can be considered a disorder of plasticity, associated with molecular abnormalities of the glutamate synapse...
  27. ncbi request reprint Increased expression of glutaminase and glutamine synthetase mRNA in the thalamus in schizophrenia
    Emile G Bruneau
    Mental Health Research Institute and Department of Psychiatry, University of Michigan Medical School, 205 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Schizophr Res 75:27-34. 2005
    ..Increased PAG and GS transcripts suggest enhanced glutamatergic neurotransmission in the thalamus and its efferent targets in schizophrenia...
  28. ncbi request reprint Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia
    Daya S Gupta
    Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109 0720, USA
    Synapse 57:123-31. 2005
    ....
  29. ncbi request reprint Striatal excitatory amino acid transporter transcript expression in schizophrenia, bipolar disorder, and major depressive disorder
    Robert E McCullumsmith
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Neuropsychopharmacology 26:368-75. 2002
    ..These results suggest that changes in striatal transporter mRNA expression are restricted to neuronal EAATs and extend the body of evidence implicating abnormal glutamatergic neurotransmission in schizophrenia and mood disorders...

Research Grants2

  1. Glutamate Transporter Expression in Schizophrenia
    Robert McCullumsmith; Fiscal Year: 2007
    ....