Research Topics
| Jeffrey McCulloughSummaryAffiliation: University of Minnesota Country: USA Publications
Research Grants
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Detail Information
Publications
Clinical safety of platelets photochemically treated with amotosalen HCl and ultraviolet A light for pathogen inactivation: the SPRINT trialEdward Snyder
Yale University Medical School, Yale-New Haven Hospital, New Haven, Connecticut, USA
Transfusion 45:1864-75. 2005..25% control; p = 0.03]) and skin rashes (56% PCT vs. 42% control; p < 0.001) were significantly more frequent in the PCT group. CONCLUSION: The overall safety profile of PCT PLTs was comparable to untreated PLTs...
Long-term storage of peripheral blood stem cells frozen and stored with a conventional liquid nitrogen technique compared with cells frozen and stored in a mechanical freezerJeffrey McCullough
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
Transfusion 50:808-19. 2010..We compared the liquid nitrogen method with methods using a combination of dimethyl sulfoxide (DMSO) and hydroxyethyl starch (HES) for cryopreservation followed by storage in mechanical freezers...- The National Marrow Donor Program with emphasis on the early yearsJeffrey McCullough
University of Minnesota, Minneapolis, Minnesota 55455, USA
Transfusion 46:1248-55. 2006 - White particulate matter: report of the ad hoc industry review groupJeffrey McCullough
University of Minnesota, Minneapolis, Minnesota, USA
Transfusion 44:1112-8. 2004..An expert panel was formed to evaluate studies of the material and make appropriate recommendations.. - Transfusion medicine: discipline with a futureJeffrey McCullough
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55455, USA
Transfusion 43:823-8. 2003 - The role of physicians in blood centersJeffrey McCullough
Department of Laboratory Medicine and Pathology, Biomedical Engineering Institute, University of Minnesota, Minneapolis, Minnesota 55455, USA
Transfusion 46:854-61. 2006 - Issues in the quality of umbilical cord blood stem cells for transplantationJeffrey McCullough
Clinical Cell Therapy Laboratory and the Blood and Marrow Transplant Program, University of Minnesota, Minneapolis, Minnesota 55455, USA
Transfusion 45:832-41. 2005..Because the frequency of umbilical cord blood (UCB) stem cell transplantation has increased, the quality of UCB available in banks is an important part of the success of UCB stem cell transplants... 
Mislabeled units of umbilical cord blood detected by a quality assurance program at the transplantation centerJeffrey McCullough
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
Blood 114:1684-8. 2009..2%) cord blood units sent to us for transplantation were mislabeled and potentially would have been transplanted incorrectly. This error rate of 1 per 249 (0.4%) patients could have potentially devastating consequences...- Overview of platelet transfusionJeffrey McCullough
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
Semin Hematol 47:235-42. 2010..Transfusion is helpful to treat nonsurgical serious bleeding. In idiopathic thrombocytopenic purpura, platelet survival is short and transfusion is useful only for severe bleeding... - Career activities of physicians taking the subspecialty board examination in blood banking/transfusion medicineJeffrey McCullough
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Transfusion 48:762-7. 2008..Changes in blood banking and transfusion medicine (BB/TM) in the past 15 years may have made BB/TM a less attractive career choice than previously for physicians... - Therapeutic efficacy and safety of platelets treated with a photochemical process for pathogen inactivation: the SPRINT TrialJeffrey McCullough
University of Minnesota, MMC 609, 420 Delaware Street SE, Minneapolis, MN 55455, USA
Blood 104:1534-41. 2004..02). The incidence of grade 2 bleeding was equivalent for PCT and conventional platelets, although posttransfusion platelet count increments and days to next transfusion were decreased for PCT compared with conventional platelets... - Cell loss and recovery in umbilical cord blood processing: a comparison of postthaw and postwash samplesVincent Laroche
Department of Laboratory Medicine and Pathology, Division of Transfusion Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
Transfusion 45:1909-16. 2005..This study examines the effect of the wash step as well as that of PT storage on various quality control variables of UCB units... - Impact of donor- and collection-related variables on product quality in ex utero cord blood bankingSabeen Askari
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota 55417, USA
Transfusion 45:189-94. 2005..Optimizing product quality is a current focus in cord blood banking. This study evaluates the role of selected donor- and collection-related variables... - Microbial contamination of hematopoietic stem cell products: incidence and clinical sequelaeMark A Klein
Division of Hematology, Oncology and Transplantation, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
Biol Blood Marrow Transplant 12:1142-9. 2006..Prophylactic antibiotics are useful for certain contaminants; however, caution must be exercised when gram-negative contaminated products are administered... - Pathogen inactivation of platelets with a photochemical treatment with amotosalen HCl and ultraviolet light: process used in the SPRINT trialAlvaro Pineda
Mayo Clinic, Rochester, Minnesota, USA
Transfusion 46:562-71. 2006..Process control was achieved under blood bank operating conditions... - The role of the paternal health history in cord blood bankingSabeen Askari
Cord Blood Program, American Red Cross North Central Blood Services, St Paul, Minnesota, USA
Transfusion 42:1275-8. 2002..Whereas most UCB banks do not require paternal consent or paternal health history (PHH), both are obtained at this institution whenever possible. This study assessed the value of PHH in making UCB safer... - Patient care during infusion of hematopoietic progenitor cellsAnnette Sauer-Heilborn
Division of Transfusion Medicine, Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Transfusion 44:907-16. 2004 - Short-term liquid storage of umbilical cord bloodAllison Hubel
Department of Mechanical Engineering, University of Minnesota, 1100 Mechanical Engineering, 111 Church Steet SE, Minneapolis, MN 55455, USA
Transfusion 43:626-32. 2003..Processing and banking of umbilical cord blood requires the development of methods for short-term liquid storage. This study examines the conditions (temperature, time, and storage solution) for optimal storage of cord blood... - Status of blood banking and the blood supply in AfghanistanM Tayyeb Ayyoubi
Department of Laboratory Medicine and Pathology, Institute for Engineering in Medicine, Medical School, University of Minnesota, Minneapolis, Minnesota 55455, USA
Transfusion 50:566-74. 2010..We carried out an assessment of that blood supply system to determine the type and extent of assistance needed to increase blood availability and safety... - Using lean techniques to define the platelet (PLT) transfusion process and cost-effectiveness to evaluate PLT dose transfusion strategiesWilliam Riley
Department of Health Policy and Management, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455, USA
Transfusion 52:1957-67. 2012..4 × 10(11) /m(2) body surface area are equally effective in preventing bleeding. These different dose strategies involve different numbers of transfusions. We conducted a cost analysis of three separate PLT dose therapies... - Platelet utilization and the transfusion trigger: a prospective analysisEdward Greeno
Department of Medicine and Laboratory Medicine, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Transfusion 47:201-5. 2007..Prophylactic platelet (PLT) transfusion practices have become more conservative as studies support a threshold for transfusions at 10 x 10(9) per L. This change in practice may reduce our use of PLT transfusions... - Pathogen inactivation: a new paradigm for preventing transfusion-transmitted infectionsJeffrey McCullough
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
Am J Clin Pathol 128:945-55. 2007..The shortcomings of our present paradigm for preventing transfusion-transmitted diseases are described, along with a summary of the status of pathogen inactivation... - Progress toward a pathogen-free blood supplyJeffrey McCullough
Department of Laboratory Medicine and Pathology and Biomedical Engineering Institute, University of Minnesota, Minneapolis, MN 55455, USA
Clin Infect Dis 37:88-95. 2003..If these encouraging results are sustained, the risk of transfusion-transmitted disease may be nearly eliminated... - Good manufacturing practices production of natural killer cells for immunotherapy: a six-year single-institution experienceDavid H McKenna
Department of Laboratory Medicine and Pathology, Division of Transfusion Medicine, University of Minnesota Medical School, Minnesota 55108, USA
Transfusion 47:520-8. 2007..Herein is a report on the experience of clinical-scale, good manufacturing practices (GMPs) production of NK cells to treat advanced cancer... - Meaningful use of health information technology by rural hospitalsJeffrey McCullough
Division of Health Policy and Management, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Rural Health 27:329-37. 2011.... - The Minnesota Molecular and Cellular Therapeutics Facility: a state-of-the-art biotherapeutics engineering laboratoryDavid H McKenna
Division of Minnesota Molecular and Cellular Therapeutics Facility, University of Minnesota, Saint Paul, MN 55108, USA
Transfus Med Rev 19:217-28. 2005..Here we provide an overview of the Minnesota Molecular and Cellular Therapeutics (MMCT) Facility, detailing our approach to the manufacture of novel therapeutics and highlighting current and future activities... - Effects of granulocyte-colony stimulating factor on chromosome aneuploidy and replication asynchrony in healthy peripheral blood stem cell donorsBetsy Hirsch
Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, USA
Blood 118:2602-8. 2011..No evidence was found of G-CSF-induced chromosomal instability. This work supports the epidemiologic data that have demonstrated no increased risk for hematologic malignancies in G-CSF-primed PBSC donors... - A phased consent policy for cord blood donationDorothy E Vawter
Minnesota Center for Health Care Ethics, 601 25th Avenue South, Minneapolis, MN 55454, USA
Transfusion 42:1268-74. 2002.... - Consensus conference on vCJD screening of blood donors: report of the panelJeffrey McCullough
University of Minnesota, Minneapolis, Minnesota 55455, USA
Transfusion 44:675-83. 2004 - Stored platelets contain residual amounts of tissue factor: evidence from studies on platelet concentrates stored for prolonged periodsSilvia Perez-Pujol
Department of Medicine and Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, Minnesota, USA
Transfusion 45:572-9. 2005..The advent of new strategies for pathogen reduction has raised the question of whether platelet (PLT) concentrates (PCs) exposed to longer periods of storage retain adequate hemostatic function... - The influence of bleeding on trigger changes for platelet transfusion in patients with chemotherapy-induced thrombocytopeniaBenjamin Rioux-Massé
From the Department of Laboratory Medicine and Pathology, Masonic Cancer Center, Institute for Engineering in Medicine, University of Minnesota Medical School, Minneapolis, Minnesota the Centre Hospitalier de l Université de Montréal, Universite de Montreal, Montreal, Quebec, Canada and the Centre de Recherche FRSQ du Centre Hospitalier affilié Universitaire de Québec, Quebec, Quebec, Canada
Transfusion 53:306-14. 2013..For patients with thrombocytopenia without bleeding risk factors, a platelet transfusion trigger of 10 × 10(9) /L is recommended. No studies have evaluated the clinicians' decision-making process leading to trigger changes... - The United States' potential blood donor pool: estimating the prevalence of donor-exclusion factors on the pool of potential donorsWilliam Riley
School of Public Health, Laboratory Medicine and Pathology, The University of Minnesota, Minneapolis, Minnesota 55455, USA
Transfusion 47:1180-8. 2007..An epidemiologic model has been developed to determine the prevalence of donor exclusions and thus improve the estimate of total eligible blood donors in the nation... - Pathogen inactivation: a new paradigm for blood safetyJeffrey McCullough
Transfusion 47:2180-4. 2007 - Non-frozen preservation of umbilical cord bloodUlrike F Koenigbauer
Transfusion 42:1383-4. 2002 - Factors affecting posttransfusion platelet increments, platelet refractoriness, and platelet transfusion intervals in thrombocytopenic patientsSherrill J Slichter
Puget Sound Blood Center, Seattle, WA 98104 1256, USA
Blood 105:4106-14. 2005..The only factors that reduced platelet refractoriness rates were increasing the dose of platelets transfused or transfusing filtered apheresis platelets... - Blood collection and transfusion in the United States in 1997Marian T Sullivan
National Blood Data Resource Center, 8101 Glenbrook Road, Bethesda, MD 20814, USA
Transfusion 42:1253-60. 2002..Collections, processing, and transfusions of blood and blood components in the US in 1997 were measured and compared with 1994 and prior years... - Platelet dose consistency and its effect on the number of platelet transfusions for support of thrombocytopenia: an analysis of the SPRINT trial of platelets photochemically treated with amotosalen HCl and ultraviolet A lightScott Murphy
American Red Cross Blood Services, Philadelphia, Pennsylvania, USA
Transfusion 46:24-33. 2006..Lower CIs and shorter transfusion intervals for PCT PLTs suggest that some PLT injury may occur during PCT. This injury does not result in a detectable increase in bleeding, however... - Relationship between tick bites and the seroprevalence of Babesia microti and Anaplasma phagocytophila (previously Ehrlichia sp.) in blood donorsDavid A Leiby
Transmissible Diseases Department, American Red Cross, Rockville, MD 20855, USA
Transfusion 42:1585-91. 2002..Despite an increased recognition of the threat tick-borne agents pose to blood safety, our understanding of the prevalence and transmissibility of these agents in blood donors is limited... - Therapeutic efficacy and safety of red blood cells treated with a chemical process (S-303) for pathogen inactivation: a Phase III clinical trial in cardiac surgery patientsRichard J Benjamin
Joint Program in Transfusion Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Transfusion 45:1739-49. 2005..A randomized, double-blind trial is reported of the clinical efficacy of red blood cells (RBCs) treated for pathogen inactivation with S-303, a synthetic labile alkylating agent...
Research Grants
- RESEARCH TRAINING IN TRANSFUSION MEDICINEJeffrey McCullough; Fiscal Year: 2003..abstract_text> ..
- Clinical Trials in Transfusion Medicine and HemostasisJeffrey McCullough; Fiscal Year: 2007..Disseminate results of the TMH CTN through presentation and publication of clinical trial results and other TMH CTN activities. UNIVERSITY OF MINNESOTA CRITIQUES ..