Research Topics
Genomes and GenesSpecies | Andrew McCullochSummaryAffiliation: University of California Country: USA Publications
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Publications
Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysisJacob D Feala
Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
BMC Syst Biol 3:91. 2009..We applied these techniques to compare metabolic activity during acute hypoxia in muscle tissue of adapted versus "naïve" control flies...- Flow-function relations during graded coronary occlusions in the dog: effects of transmural location and segment orientationA D McCulloch
Department of Bioengineering, University of California San Diego, La Jolla 92093 0412, USA
Cardiovasc Res 37:636-45. 1998..The aim of this study was to determine the effects of fiber orientation and transmural location on the relationships between regional myocardial flow and three-dimensional systolic wall strain during graded coronary artery occlusions... - Regional myocardial mechanics: integrative computational models of flow-function relationsA D McCulloch
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, Calif 92093 0412, USA
J Nucl Cardiol 8:506-19. 2001.... - Functionally and structurally integrated computational modeling of ventricular physiologyAndrew D McCulloch
Department of Bioengineering, Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, CA 92093 0412, USA
Jpn J Physiol 54:531-9. 2004..We describe examples of all three categories of integration by using recent advances in modeling cardiac excitation-contraction coupling and whole-heart electromechanics in health and disease... - Cardiac systems biologyAndrew D McCulloch
Department of Bioengineering, University of California San Diego, 9500 Gioman Drive, La Jolla, CA 92093 0412, USA
Ann N Y Acad Sci 1047:283-95. 2005..This review gives examples of recent applications using these approaches to elucidate the electromechanical function of the heart in aging and disease... - Early postmyocardial infarction survival in Murphy Roths Large mice is mediated by attenuated apoptosis and inflammation but depends on genetic backgroundDarlene L Hunt
Department of Bioengineering, University of California at San Diego, La Jolla, CA, USA
Exp Physiol 97:102-14. 2012..The intermediate survival, apoptosis and inflammation profile of LG/J mice suggests that this high tolerance for MI in the MRL mouse could be derived from its shared genetic background with the LG/J mouse... - The cobalamin precursor cobinamide detoxifies nitroprusside-generated cyanideKate E Broderick
Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0652, USA
Exp Biol Med (Maywood) 232:789-98. 2007..5-5 times that of nitroprusside, it did not decrease NO concentrations or the physiological effectiveness of nitroprusside. We conclude that cobinamide could be a valuable adjunct to nitroprusside therapy... - Relationship between regional shortening and asynchronous electrical activation in a three-dimensional model of ventricular electromechanicsTaras P Usyk
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California, San Diego, La Jolla, California 92093-0412, USA
J Cardiovasc Electrophysiol 14:S196-202. 2003.... - Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissueJeffrey J Saucerman
Department of Bioengineering, Whitaker Institute of Biomedical Engineering, University of California San Diego, La Jolla92037-0412, USA
Circ Res 95:1216-24. 2004.... - Mechanisms of transmurally varying myocyte electromechanics in an integrated computational modelStuart G Campbell
Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
Philos Transact A Math Phys Eng Sci 366:3361-80. 2008.... - Ventricular dilation and electrical dyssynchrony synergistically increase regional mechanical nonuniformity but not mechanical dyssynchrony: a computational modelRoy C P Kerckhoffs
Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, Calif, USA
Circ Heart Fail 3:528-36. 2010..The goal of this study was to compare the sensitivity of these indices to 4 major abnormalities responsible for cardiac dysfunction in dyssynchronous HF: dilation, negative inotropy, negative lusitropy, and dyssynchronous activation... - Multiscale modeling in rodent ventricular myocytesShaoying Lu
Department of Bioengineering, University of California San Diego, La Jolla, 92093 0412, USA
IEEE Eng Med Biol Mag 28:46-57. 2009..Subsequent studies have demonstrated that the t-tubular system has also longitudinal extensions [9]--[11], [13]... - Mechanisms of conduction slowing during myocardial stretch by ventricular volume loading in the rabbitRobert W Mills
Department of Bioengineering, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
Am J Physiol Heart Circ Physiol 295:H1270-H1278. 2008.... - Asynchrony of ventricular activation affects magnitude and timing of fiber stretch in late-activated regions of the canine heartBenjamin A Coppola
UCSD School of Medicine, Department of Cardiology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Am J Physiol Heart Circ Physiol 293:H754-61. 2007..The increased shortening of these regions appears to be because of a reduced afterload rather than an effect of length-dependent activation in this preparation... - Effect of transmurally heterogeneous myocyte excitation-contraction coupling on canine left ventricular electromechanicsStuart G Campbell
Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
Exp Physiol 94:541-52. 2009..These results suggest that in the intact ventricle heterogeneously distributed myocyte subtypes primarily impact local deformation of the myocardium, and that these effects are greatest during early systole... - An ionic model of stretch-activated and stretch-modulated currents in rabbit ventricular myocytesSarah N Healy
Department of Bioengineering, University of California, San Diego, 92093, USA
Europace 7:128-34. 2005..CONCLUSION: Transmural heterogeneity of I(Ko) may reduce repolarization gradients in intact myocardium caused by intrinsic ion channel densities, nonuniform strains and electrotonic effects... - Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophyKeith L Herrmann
Whitaker Institute of Biomedical Engineering, University of California-San Diego, La Jolla, California 92093, USA
Am J Physiol Heart Circ Physiol 284:H1277-84. 2003.... - Ventricular filling slows epicardial conduction and increases action potential duration in an optical mapping study of the isolated rabbit heartDerrick Sung
Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0412, USA
J Cardiovasc Electrophysiol 14:739-49. 2003.... - Modeling transmural heterogeneity of K(ATP) current in rabbit ventricular myocytesAnushka Michailova
Dept of Bioengineering, PFBH 241, University of California San Diego, La Jolla, CA 92093 0412, USA
Am J Physiol Cell Physiol 293:C542-57. 2007..The model predictions are in qualitative agreement with experimental data measured under normal and ischemic conditions in rabbit ventricular myocytes... - Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulationJeffrey J Saucerman
Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093-0412, USA
Prog Biophys Mol Biol 85:261-78. 2004..Combined with detailed experimental studies, mechanistic systems models will be valuable for developing a quantitative understanding of cell signaling networks... - Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathyAlice E Zemljic-Harpf
Department of Medicine, UCSD School of Medicine, La Jolla, California, USA
Mol Cell Biol 27:7522-37. 2007..This is the first report of tissue-specific inactivation of the Vcl gene and shows that it is required for preservation of normal cell-cell and cell-matrix adhesive structures... - Contributions of sustained INa and IKv43 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytesSarah N Flaim
University of California, San Diego, La Jolla, CA 92093 0412, USA
Am J Physiol Heart Circ Physiol 291:H2617-29. 2006..By design, these models allow upward integration into organ models or may be used as a basis for further investigations into cellular heterogeneities... - Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomersSindhu M Gopalan
Department of Bioengineering, Whitaker Institute for Biomedical Engineering, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093-0412, USA
Biotechnol Bioeng 81:578-87. 2003.... - Effects of biglycan deficiency on myocardial infarct structure and mechanicsPatrick H Campbell
Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
Mol Cell Biomech 5:27-35. 2008..Null-expression of biglycan may alter collagen fibril ultrastructure, and thereby influence scar mechanics and remodeling... - Coupling of a 3D finite element model of cardiac ventricular mechanics to lumped systems models of the systemic and pulmonic circulationRoy C P Kerckhoffs
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
Ann Biomed Eng 35:1-18. 2007..The coupling method allows for simulations of multiple cardiac cycles for normal and pathophysiology, encompassing levels from cell to system... - A myocardial lineage derives from Tbx18 epicardial cellsChen Leng Cai
Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California 92093, USA
Nature 454:104-8. 2008..The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration... - Electromechanical model of cardiac resynchronization in the dilated failing heart with left bundle branch blockTaras P Usyk
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California, San Diego, La Jolla 92093 0412, USA
J Electrocardiol 36:57-61. 2003.... - A role for decorin in the remodeling of myocardial infarctionSara M Weis
Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093, USA
Matrix Biol 24:313-24. 2005..This might contribute to aneurysmal ventricular dilatation, remote hypertrophy, and depressed ventricular function... - Computational modeling for bedside applicationRoy C P Kerckhoffs
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, CA 92093 0412, USA
Heart Fail Clin 4:371-8. 2008..Models, therefore, will provide insight as to why specific interventions succeed or fail... - Effects of biventricular pacing and scar size in a computational model of the failing heart with left bundle branch blockRoy C P Kerckhoffs
Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
Med Image Anal 13:362-9. 2009..To study the impact of biventricular pacing (BiV) and scar size on left ventricular (LV) regional and global function using a detailed finite element model of three-dimensional electromechanics in the failing canine heart... - Arrhythmogenic consequences of Na+ channel mutations in the transmurally heterogeneous mammalian left ventricle: analysis of the I1768V SCN5A mutationSarah N Flaim
Department of Bioengineering, University of California, San Diego, La Jolla, California 92093 0412, USA
Heart Rhythm 4:768-78. 2007..However, the I1768V SCN5A mutation is associated with faster recovery kinetics, for which there exists no known pharmacologic equivalent... - Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shearIlka Lorenzen-Schmidt
Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0613, USA
Cell Biochem Biophys 46:113-22. 2006..The results suggest that the beta-adrenergic signaling pathway and integrin activation, which are known to interact, may play an important role in the response mechanism... - Effects of Mg2+, pH and PCr on cardiac excitation-metabolic couplingAnushka Michailova
Department of Bioengineering, PFBH 241, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
Magnes Res 21:16-28. 2008..The model reproduces qualitatively a sequence of events that correlates well with the experimental data... - Metabolomic and flux-balance analysis of age-related decline of hypoxia tolerance in Drosophila muscle tissueLaurence Coquin
Burnham Institute, La Jolla, CA, USA
Mol Syst Biol 4:233. 2008.... - Effects of magnesium on cardiac excitation-contraction couplingAnushka P Michailova
Department of Bioengineering, PFBH 241, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
J Am Coll Nutr 23:514S-517S. 2004..Small changes in intracellular free Mg(2+) ([Mg(2+)](i)) may have important effects on cardiac excitability and contractility. We investigated the effects of [Mg(2+)](i) on cardiac excitation-contraction coupling... - Modeling regulation of cardiac KATP and L-type Ca2+ currents by ATP, ADP, and Mg2+Anushka Michailova
Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA
Biophys J 88:2234-49. 2005..The model predictions are in agreement with experimental data measured under normal and a variety of pathological conditions... - Muscle LIM protein deficiency leads to alterations in passive ventricular mechanicsJeffrey H Omens
Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
Am J Physiol Heart Circ Physiol 282:H680-7. 2002.... - High-resolution longitudinal MRI of the transition to heart failurePeter N Costandi
Department of Bioengineering, University of California San Diego, La Jolla, California 92093 0613, USA
Magn Reson Med 57:714-20. 2007.... - Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathyIlka Lorenzen-Schmidt
Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
J Mol Cell Cardiol 39:241-50. 2005..These results indicate that the progression to heart failure in the MLPKO model may be driven by diastolic myocardial dysfunction and abnormal passive properties rather than systolic dysfunction... - Deficiency of actinin-associated LIM protein alters regional right ventricular function and hypertrophic remodelingIlka Lorenzen-Schmidt
Department of Bioengineering, University of California San Diego, 9500 Gilman Dr, La Jolla 92093, CA, USA
Ann Biomed Eng 33:888-96. 2005..In summary, the results are consistent with the view that disruption of ALP is associated with diminished RV contractile function as well as altered hypertrophic remodeling... - Cardiac myocyte force development during differentiation and maturationJeffrey G Jacot
Department of Bioengineering, Rice University, and Division of Congenital Heart Surgery, Texas Children s Hospital, Houston, Texas, USA
Ann N Y Acad Sci 1188:121-7. 2010..These results suggest that extracellular stiffness significantly affects maturation and differentiation of immature ventricular myocytes... - Multi-scale modeling of excitation-contraction coupling in the normal and failing heartRoy C P Kerckhoffs
Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA
Conf Proc IEEE Eng Med Biol Soc 2009:4281-2. 2009..We summarize application to human genetic diseases (LQT1 and LQT3) and to modeling of congestive heart failure... - Role of diastolic properties in the transition to failure in a mouse model of the cardiac dilatationPeter N Costandi
Dept of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0613, USA
Am J Physiol Heart Circ Physiol 291:H2971-9. 2006..Though initially compensatory, this process may exhaust itself and consequently transition to a maladaptive course... - Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytesJeffrey G Jacot
Department of Bioengineering, University of California, San Diego, USA
Biophys J 95:3479-87. 2008..On very stiff substrates, this adaptation seems to involve RhoA kinase... - A more efficient search strategy for aging genes based on connectivityLuca Ferrarini
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Bioinformatics 21:338-48. 2005..The model suggests that aging genes tend to have a higher number of connections and therefore supports a strategy, based on connectivity, for prioritizing what might otherwise be a random search for aging genes... - Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heartByung Kwan Lim
Department of Medicine, University of California San Diego, Division of Cardiology, La Jolla, California 92093 0613, USA
J Clin Invest 118:2758-70. 2008..Furthermore, localization of connexin 45 at the AV-node cell-cell junction and of beta-catenin and ZO-1 at the ventricular intercalated disc are dependent on CAR... - An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in miceFarah Sheikh
Department of Medicine, UCSD, La Jolla, California 92093, USA
J Clin Invest 118:3870-80. 2008..These studies shed light on the physiological regulation of the sarcomere in response to hypertrophic stress... - Coupling of adjacent tropomyosins enhances cross-bridge-mediated cooperative activation in a markov model of the cardiac thin filamentStuart G Campbell
Department of Bioengineering, University of California San Diego, La Jolla, California, USA
Biophys J 98:2254-64. 2010..Without excluding other putative cooperative mechanisms, these findings suggest that structural coupling of adjacent Tm molecules contributes to several properties of cardiac myofilament activation... - Cardiac beta-adrenergic signaling: from subcellular microdomains to heart failureJeffrey J Saucerman
Department of Bioengineering, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0412, USA
Ann N Y Acad Sci 1080:348-61. 2006..Here, we review recent basic insights and novel quantitative approaches that are leading to a more comprehensive understanding of beta-adrenergic signaling and thus motivate new therapeutic strategies for cardiac disease... - Integrating metabolomics and phenomics with systems models of cardiac hypoxiaJacob D Feala
Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Prog Biophys Mol Biol 96:209-25. 2008..Here we present a framework for a systems approach to hypoxia in the cardiac myocyte, starting from nuclear magnetic resonance (NMR) metabolomics, a constraint-based metabolic model, and phenotypic profiles... - Hypertrophic gene expression induced by chronic stretch of excised mouse heart muscleAnna M Raskin
Department of Bioengineering, University of California San Diego, CA 92093, USA
Mol Cell Biomech 6:145-59. 2009..Load induced ANP expression was blunted in muscles from muscle-LIM protein knockout mice, in which defective mechanotransduction pathways have been predicted... - The nitric oxide scavenger cobinamide profoundly improves survival in a Drosophila melanogaster model of bacterial sepsisKate E Broderick
Department of Medicine, University of California San Diego, La Jolla 92093-0652, USA
FASEB J 20:1865-73. 2006..Cobinamide augmented the effect of an antibiotic and was beneficial even in immune-deficient flies. Cobinamide's mechanism of action appeared to be from reducing NO levels and improving cardiac function... - Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytesJeffrey J Saucerman
Department of Bioengineering, Whitaker Institute of Biomedical Engineering, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 103:12923-8. 2006..These findings indicate that combining live-cell FRET imaging and mechanistic computational models can provide quantitative understanding of spatiotemporal signaling... - Discovering regulators of the Drosophila cardiac hypoxia response using automated phenotyping technologyJacob D Feala
Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, 0412, La Jolla, CA 92093 0412, USA
Ann N Y Acad Sci 1123:169-77. 2008..We discuss the possible applications of a genome-wide cardiac phenotype data set in systems biology analyses of hypoxic metabolism, using genome-scale interaction networks and constraint-based metabolic models... - Flexibility in energy metabolism supports hypoxia tolerance in Drosophila flight muscle: metabolomic and computational systems analysisJacob D Feala
Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA
Mol Syst Biol 3:99. 2007..Simulations supported the hypothesis that the ability to flexibly convert pyruvate to these three by-products might convey hypoxia tolerance by improving the ATP/H(+) ratio and efficiency of glucose utilization... - Search algorithms as a framework for the optimization of drug combinationsDiego Calzolari
Burnham Institute for Medical Research, La Jolla, CA, USA
PLoS Comput Biol 4:e1000249. 2008..This report also helps to frame a biomedical problem that will benefit from an interdisciplinary effort and suggests a general strategy for its solution... - Integrative biological modelling in silicoAndrew D McCulloch
Department of Bioengineering, The Whitaker Institute of Biomedical Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0412, USA
Novartis Found Symp 247:4-19; discussion 20-5, 84-90, 244-52. 2002.... - Left ventricular form and function: scientific priorities and strategic planning for development of new views of diseaseGerald D Buckberg
University of California, Los Angeles, USA
Circulation 110:e333-6. 2004 - Effect of stimulation rate, sarcomere length and Ca(2+) on force generation by mouse cardiac muscleBruno D Stuyvers
University of Calgary, Health Sciences Center, Department of Medicine, Physiology and Biophysics, Alberta, Canada
J Physiol 544:817-30. 2002..These results may suggest a lower capacity of the SR for buffering Ca(2+), which makes the generation of force in mouse cardiac ventricle more dependent on Ca(2+) entering during action potentials, particularly at high heart rate... - Structural and functional roles of desmin in mouse skeletal muscle during passive deformationSameer B Shah
Departments of Bioengineering and Orthopaedics, Biomedical Sciences Graduate Group, University of California and Veterans Administration Medical Centers, San Diego, California 92161, USA
Biophys J 86:2993-3008. 2004..Finally, linkage of desmin intermediate filaments to muscle nuclei was strongly suggested based on extensive loss of nuclei positioning in the absence of desmin during passive fiber loading... - Microstructured cocultures of cardiac myocytes and fibroblasts: a two-dimensional in vitro model of cardiac tissuePatrizia Camelliti
University Laboratory of Physiology, Oxford, OX1 3PT, UK
Microsc Microanal 11:249-59. 2005..We conclude that structured cocultures of cardiomyocytes and fibroblasts mimic in vivo ventricular tissue organization and provide a novel tool for in vitro research into cardiac electromechanical function... - Nonhomogeneous deformation in the anterior leaflet of the mitral valveLing Chen
Department of Mechanical Engineering, San Diego State University, San Diego, CA 92182-1323, USA
Ann Biomed Eng 32:1599-606. 2004..This information can be used to better understand how the valve deforms under physiological loading, and to help design treatments for valve problems, such as mitral regurgitation... - The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathyRalph Knoll
Institute of Molecular Medicine, Department of Medicine, University of California at San Diego, La Jolla 92093, USA
Cell 111:943-55. 2002..We propose that a Z disc MLP/T-cap complex is a key component of the in vivo cardiomyocyte stretch sensor machinery, and that defects in the complex can lead to human DCM and associated heart failure... - Myocyte shearing, myocardial sheets, and microtubulesAndrew D McCulloch
Circ Res 98:1-3. 2006 - Cell cultures as models of cardiac mechanoelectric feedbackYibing Zhang
Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21205, USA
Prog Biophys Mol Biol 97:367-82. 2008.... - Micropatterned cell cultures on elastic membranes as an in vitro model of myocardiumPatrizia Camelliti
Department of Physiology, Anatomy and Genetics, Parks Road, Oxford OX1 3PT, UK
Nat Protoc 1:1379-91. 2006..The entire process from fabrication of the micropatterned silicon metal wafers to casting of silicone molds, microfluidic patterning and cell isolation and seeding takes approximately 7 days... - Modeling beta-adrenergic control of cardiac myocyte contractility in silicoJeffrey J Saucerman
U CA San Diego, La Jolla
J Biol Chem 278:47997-8003. 2003..By performing systems analysis, the consequences of molecular perturbations in the beta-adrenergic signaling network may be understood within the context of integrative cellular physiology... - Acetylcholine-induced shortening of the epicardial action potential duration may increase repolarization gradients and LQT3 arrhythmic riskSarah N Flaim
Oxford University Computing Laboratory, University of Oxford, Oxford, United Kingdom
J Electrocardiol 40:S66-9. 2007..Our results suggest that ACh-mediated effects on epicardial myocytes may amplify already steep repolarisation gradients in the mammalian left ventricular wall of LQT3 patients and consequently increase the risk of arrhythmia formation... - The role of mechanoelectric feedback in vulnerability to electric shockWeihui Li
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
Prog Biophys Mol Biol 97:461-78. 2008.... - Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summaryYoram Rudy
Cardiac Bioelectricity and Arrhythmia Center, The Fred Saigh Distinguished Professor, Washington University, Campus Box 1097, Whitaker Hall Room 290B, One Brookings Dr, St Louis, MO 63130 4899, USA
Circulation 118:1202-11. 2008..The recommendations can be found on the NHLBI Web site at http://www.nhlbi.nih.gov/meetings/workshops/electro.htm... - New multi-cue bioreactor for tissue engineering of tubular cardiovascular samples under physiological conditionsAndrew D McCulloch
Centre for Tissue Engineering Research, Department of Biomedical Sciences, University of Westminster, London, United Kingdom
Tissue Eng 10:565-73. 2004..The MCB represents a versatile model that will enable the development of tissue engineering not only for cardiovascular tissue, but for all tubular tissues such as esophageal, tracheal, and bronchial systems...
Research Grants
- Multi-Scale Modeling of the Failing Heart for Cardiac Rysynchronization TherapyAndrew D McCulloch; Fiscal Year: 2010..The models can then be used to predict the outcome - and thus to improve the number of patients to respond - and optimize this pacemaker therapy for patients. ..
- Three-Dimentional Micropatterned Cardiac Tissue CulturesAndrew McCulloch; Fiscal Year: 2004..abstract_text> ..
- Multi-Scale Modeling of the Failing Heart for Cardiac Rysynchronization TherapyAndrew McCulloch; Fiscal Year: 2009..The models can then be used to predict the outcome - and thus to improve the number of patients to respond - and optimize this pacemaker therapy for patients. ..