Andrew McCulloch

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Mechanisms of transmurally varying myocyte electromechanics in an integrated computational model
    Stuart G Campbell
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
    Philos Trans A Math Phys Eng Sci 366:3361-80. 2008
  2. pmc Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis
    Jacob D Feala
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    BMC Syst Biol 3:91. 2009
  3. ncbi request reprint Flow-function relations during graded coronary occlusions in the dog: effects of transmural location and segment orientation
    A D McCulloch
    Department of Bioengineering, University of California San Diego, La Jolla 92093 0412, USA
    Cardiovasc Res 37:636-45. 1998
  4. ncbi request reprint Cardiac systems biology
    Andrew D McCulloch
    Department of Bioengineering, University of California San Diego, 9500 Gioman Drive, La Jolla, CA 92093 0412, USA
    Ann N Y Acad Sci 1047:283-95. 2005
  5. ncbi request reprint Functionally and structurally integrated computational modeling of ventricular physiology
    Andrew D McCulloch
    Department of Bioengineering, Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, CA 92093 0412, USA
    Jpn J Physiol 54:531-9. 2004
  6. pmc Early postmyocardial infarction survival in Murphy Roths Large mice is mediated by attenuated apoptosis and inflammation but depends on genetic background
    Darlene L Hunt
    Department of Bioengineering, University of California at San Diego, La Jolla, CA, USA
    Exp Physiol 97:102-14. 2012
  7. ncbi request reprint Regional myocardial mechanics: integrative computational models of flow-function relations
    A D McCulloch
    Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, Calif 92093 0412, USA
    J Nucl Cardiol 8:506-19. 2001
  8. ncbi request reprint The cobalamin precursor cobinamide detoxifies nitroprusside-generated cyanide
    Kate E Broderick
    Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0652, USA
    Exp Biol Med (Maywood) 232:789-98. 2007
  9. ncbi request reprint Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissue
    Jeffrey J Saucerman
    Department of Bioengineering, Whitaker Institute of Biomedical Engineering, University of California San Diego, La Jolla92037 0412, USA
    Circ Res 95:1216-24. 2004
  10. ncbi request reprint Relationship between regional shortening and asynchronous electrical activation in a three-dimensional model of ventricular electromechanics
    Taras P Usyk
    Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California, San Diego, La Jolla, California 92093 0412, USA
    J Cardiovasc Electrophysiol 14:S196-202. 2003

Detail Information

Publications73

  1. pmc Mechanisms of transmurally varying myocyte electromechanics in an integrated computational model
    Stuart G Campbell
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
    Philos Trans A Math Phys Eng Sci 366:3361-80. 2008
    ....
  2. pmc Metabolism as means for hypoxia adaptation: metabolic profiling and flux balance analysis
    Jacob D Feala
    Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    BMC Syst Biol 3:91. 2009
    ..We applied these techniques to compare metabolic activity during acute hypoxia in muscle tissue of adapted versus "naïve" control flies...
  3. ncbi request reprint Flow-function relations during graded coronary occlusions in the dog: effects of transmural location and segment orientation
    A D McCulloch
    Department of Bioengineering, University of California San Diego, La Jolla 92093 0412, USA
    Cardiovasc Res 37:636-45. 1998
    ..The aim of this study was to determine the effects of fiber orientation and transmural location on the relationships between regional myocardial flow and three-dimensional systolic wall strain during graded coronary artery occlusions...
  4. ncbi request reprint Cardiac systems biology
    Andrew D McCulloch
    Department of Bioengineering, University of California San Diego, 9500 Gioman Drive, La Jolla, CA 92093 0412, USA
    Ann N Y Acad Sci 1047:283-95. 2005
    ..This review gives examples of recent applications using these approaches to elucidate the electromechanical function of the heart in aging and disease...
  5. ncbi request reprint Functionally and structurally integrated computational modeling of ventricular physiology
    Andrew D McCulloch
    Department of Bioengineering, Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, CA 92093 0412, USA
    Jpn J Physiol 54:531-9. 2004
    ..We describe examples of all three categories of integration by using recent advances in modeling cardiac excitation-contraction coupling and whole-heart electromechanics in health and disease...
  6. pmc Early postmyocardial infarction survival in Murphy Roths Large mice is mediated by attenuated apoptosis and inflammation but depends on genetic background
    Darlene L Hunt
    Department of Bioengineering, University of California at San Diego, La Jolla, CA, USA
    Exp Physiol 97:102-14. 2012
    ..The intermediate survival, apoptosis and inflammation profile of LG/J mice suggests that this high tolerance for MI in the MRL mouse could be derived from its shared genetic background with the LG/J mouse...
  7. ncbi request reprint Regional myocardial mechanics: integrative computational models of flow-function relations
    A D McCulloch
    Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, Calif 92093 0412, USA
    J Nucl Cardiol 8:506-19. 2001
    ....
  8. ncbi request reprint The cobalamin precursor cobinamide detoxifies nitroprusside-generated cyanide
    Kate E Broderick
    Department of Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0652, USA
    Exp Biol Med (Maywood) 232:789-98. 2007
    ..5-5 times that of nitroprusside, it did not decrease NO concentrations or the physiological effectiveness of nitroprusside. We conclude that cobinamide could be a valuable adjunct to nitroprusside therapy...
  9. ncbi request reprint Proarrhythmic consequences of a KCNQ1 AKAP-binding domain mutation: computational models of whole cells and heterogeneous tissue
    Jeffrey J Saucerman
    Department of Bioengineering, Whitaker Institute of Biomedical Engineering, University of California San Diego, La Jolla92037 0412, USA
    Circ Res 95:1216-24. 2004
    ....
  10. ncbi request reprint Relationship between regional shortening and asynchronous electrical activation in a three-dimensional model of ventricular electromechanics
    Taras P Usyk
    Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California, San Diego, La Jolla, California 92093 0412, USA
    J Cardiovasc Electrophysiol 14:S196-202. 2003
    ..Asynchronous electrical activation can cause abnormalities in perfusion and pump function. An electromechanical model was used to investigate the mechanical effects of altered cardiac activation sequence...
  11. pmc Ventricular dilation and electrical dyssynchrony synergistically increase regional mechanical nonuniformity but not mechanical dyssynchrony: a computational model
    Roy C P Kerckhoffs
    Department of Bioengineering, Institute of Engineering in Medicine, University of California, San Diego, La Jolla, Calif, USA
    Circ Heart Fail 3:528-36. 2010
    ..The goal of this study was to compare the sensitivity of these indices to 4 major abnormalities responsible for cardiac dysfunction in dyssynchronous HF: dilation, negative inotropy, negative lusitropy, and dyssynchronous activation...
  12. pmc Sensitivity of rabbit ventricular action potential and Ca²⁺ dynamics to small variations in membrane currents and ion diffusion coefficients
    Yuan Hung Lo
    Department of Bioengineering, PFBH 241, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Biomed Res Int 2013:565431. 2013
    ..model. Our results demonstrate usefulness of sensitivity analysis to identify specific knowledge gaps and controversies related to ventricular cell electrophysiology and Ca²⁺ signaling...
  13. ncbi request reprint Modeling transmural heterogeneity of K(ATP) current in rabbit ventricular myocytes
    Anushka Michailova
    Dept of Bioengineering, PFBH 241, University of California San Diego, La Jolla, CA 92093 0412, USA
    Am J Physiol Cell Physiol 293:C542-57. 2007
    ..The model predictions are in qualitative agreement with experimental data measured under normal and ischemic conditions in rabbit ventricular myocytes...
  14. pmc Multiscale modeling in rodent ventricular myocytes
    Shaoying Lu
    Department of Bioengineering, University of California San Diego, La Jolla, 92093 0412, USA
    IEEE Eng Med Biol Mag 28:46-57. 2009
    ..Subsequent studies have demonstrated that the t-tubular system has also longitudinal extensions [9]--[11], [13]...
  15. ncbi request reprint An ionic model of stretch-activated and stretch-modulated currents in rabbit ventricular myocytes
    Sarah N Healy
    Department of Bioengineering, University of California, San Diego, 92093, USA
    Europace 7:128-34. 2005
    ..To develop an ionic model of stretch-activated and stretch-modulated currents in rabbit ventricular myocytes consistent with experimental observations, that can be used to investigate the role of these currents in intact myocardium...
  16. ncbi request reprint Ventricular filling slows epicardial conduction and increases action potential duration in an optical mapping study of the isolated rabbit heart
    Derrick Sung
    Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    J Cardiovasc Electrophysiol 14:739-49. 2003
    ..Mechanical stimulation can induce electrophysiologic changes in cardiac myocytes, but how mechanoelectric feedback in the intact heart affects action potential propagation remains unclear...
  17. pmc Asynchrony of ventricular activation affects magnitude and timing of fiber stretch in late-activated regions of the canine heart
    Benjamin A Coppola
    UCSD School of Medicine, Department of Cardiology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Am J Physiol Heart Circ Physiol 293:H754-61. 2007
    ..The increased shortening of these regions appears to be because of a reduced afterload rather than an effect of length-dependent activation in this preparation...
  18. pmc Glycated collagen cross-linking alters cardiac mechanics in volume-overload hypertrophy
    Keith L Herrmann
    Whitaker Institute of Biomedical Engineering, University of California San Diego, La Jolla, California 92093, USA
    Am J Physiol Heart Circ Physiol 284:H1277-84. 2003
    ....
  19. pmc Effect of transmurally heterogeneous myocyte excitation-contraction coupling on canine left ventricular electromechanics
    Stuart G Campbell
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Exp Physiol 94:541-52. 2009
    ..These results suggest that in the intact ventricle heterogeneously distributed myocyte subtypes primarily impact local deformation of the myocardium, and that these effects are greatest during early systole...
  20. pmc Mechanisms of conduction slowing during myocardial stretch by ventricular volume loading in the rabbit
    Robert W Mills
    Department of Bioengineering, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 295:H1270-H1278. 2008
    ....
  21. pmc Effects of biglycan deficiency on myocardial infarct structure and mechanics
    Patrick H Campbell
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Mol Cell Biomech 5:27-35. 2008
    ..Null-expression of biglycan may alter collagen fibril ultrastructure, and thereby influence scar mechanics and remodeling...
  22. pmc Coupling of a 3D finite element model of cardiac ventricular mechanics to lumped systems models of the systemic and pulmonic circulation
    Roy C P Kerckhoffs
    Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Ann Biomed Eng 35:1-18. 2007
    ..The coupling method allows for simulations of multiple cardiac cycles for normal and pathophysiology, encompassing levels from cell to system...
  23. ncbi request reprint Anisotropic stretch-induced hypertrophy in neonatal ventricular myocytes micropatterned on deformable elastomers
    Sindhu M Gopalan
    Department of Bioengineering, Whitaker Institute for Biomedical Engineering, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0412, USA
    Biotechnol Bioeng 81:578-87. 2003
    ....
  24. ncbi request reprint Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation
    Jeffrey J Saucerman
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0412, USA
    Prog Biophys Mol Biol 85:261-78. 2004
    ..Combined with detailed experimental studies, mechanistic systems models will be valuable for developing a quantitative understanding of cell signaling networks...
  25. ncbi request reprint Contributions of sustained INa and IKv43 to transmural heterogeneity of early repolarization and arrhythmogenesis in canine left ventricular myocytes
    Sarah N Flaim
    University of California, San Diego, La Jolla, CA 92093 0412, USA
    Am J Physiol Heart Circ Physiol 291:H2617-29. 2006
    ..By design, these models allow upward integration into organ models or may be used as a basis for further investigations into cellular heterogeneities...
  26. pmc Cardiac-myocyte-specific excision of the vinculin gene disrupts cellular junctions, causing sudden death or dilated cardiomyopathy
    Alice E Zemljic-Harpf
    Department of Medicine, UCSD School of Medicine, La Jolla, California, USA
    Mol Cell Biol 27:7522-37. 2007
    ..This is the first report of tissue-specific inactivation of the Vcl gene and shows that it is required for preservation of normal cell-cell and cell-matrix adhesive structures...
  27. pmc GPU acceleration of optical mapping algorithm for cardiac electrophysiology
    Pingfan Meng
    Department of Computer Science and Engineering, University of California, San Diego, 9500 Gilman Dr La Jolla, CA 92093, USA
    Conf Proc IEEE Eng Med Biol Soc 2012:1558-61. 2012
    ..Our result indicates that the GPU implementation is capable of processing the optical mapping video at 578 FPS which achieves 157.92X speed against the OpenMP optimized CPU implementation...
  28. doi request reprint A myocardial lineage derives from Tbx18 epicardial cells
    Chen Leng Cai
    Skaggs School of Pharmacy, University of California, San Diego, La Jolla, California 92093, USA
    Nature 454:104-8. 2008
    ..The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration...
  29. pmc Effects of biventricular pacing and scar size in a computational model of the failing heart with left bundle branch block
    Roy C P Kerckhoffs
    Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    Med Image Anal 13:362-9. 2009
    ..To study the impact of biventricular pacing (BiV) and scar size on left ventricular (LV) regional and global function using a detailed finite element model of three-dimensional electromechanics in the failing canine heart...
  30. ncbi request reprint High-resolution longitudinal MRI of the transition to heart failure
    Peter N Costandi
    Department of Bioengineering, University of California San Diego, La Jolla, California 92093 0613, USA
    Magn Reson Med 57:714-20. 2007
    ....
  31. ncbi request reprint Effects of Mg2+, pH and PCr on cardiac excitation-metabolic coupling
    Anushka Michailova
    Department of Bioengineering, PFBH 241, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Magnes Res 21:16-28. 2008
    ..The model reproduces qualitatively a sequence of events that correlates well with the experimental data...
  32. ncbi request reprint Effects of magnesium on cardiac excitation-contraction coupling
    Anushka P Michailova
    Department of Bioengineering, PFBH 241, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    J Am Coll Nutr 23:514S-517S. 2004
    ..Small changes in intracellular free Mg(2+) ([Mg(2+)](i)) may have important effects on cardiac excitability and contractility. We investigated the effects of [Mg(2+)](i) on cardiac excitation-contraction coupling...
  33. pmc Computational modeling for bedside application
    Roy C P Kerckhoffs
    Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California San Diego, La Jolla, CA 92093 0412, USA
    Heart Fail Clin 4:371-8. 2008
    ..Models, therefore, will provide insight as to why specific interventions succeed or fail...
  34. ncbi request reprint Arrhythmogenic consequences of Na+ channel mutations in the transmurally heterogeneous mammalian left ventricle: analysis of the I1768V SCN5A mutation
    Sarah N Flaim
    Department of Bioengineering, University of California, San Diego, La Jolla, California 92093 0412, USA
    Heart Rhythm 4:768-78. 2007
    ..However, the I1768V SCN5A mutation is associated with faster recovery kinetics, for which there exists no known pharmacologic equivalent...
  35. pmc Metabolomic and flux-balance analysis of age-related decline of hypoxia tolerance in Drosophila muscle tissue
    Laurence Coquin
    Burnham Institute, La Jolla, CA, USA
    Mol Syst Biol 4:233. 2008
    ....
  36. ncbi request reprint Muscle LIM protein deficiency leads to alterations in passive ventricular mechanics
    Jeffrey H Omens
    Department of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    Am J Physiol Heart Circ Physiol 282:H680-7. 2002
    ....
  37. pmc Substrate stiffness affects the functional maturation of neonatal rat ventricular myocytes
    Jeffrey G Jacot
    Department of Bioengineering, University of California, San Diego, USA
    Biophys J 95:3479-87. 2008
    ..On very stiff substrates, this adaptation seems to involve RhoA kinase...
  38. ncbi request reprint Deficiency of actinin-associated LIM protein alters regional right ventricular function and hypertrophic remodeling
    Ilka Lorenzen-Schmidt
    Department of Bioengineering, University of California San Diego, 9500 Gilman Dr, La Jolla 92093, CA, USA
    Ann Biomed Eng 33:888-96. 2005
    ..In summary, the results are consistent with the view that disruption of ALP is associated with diminished RV contractile function as well as altered hypertrophic remodeling...
  39. ncbi request reprint Electromechanical model of cardiac resynchronization in the dilated failing heart with left bundle branch block
    Taras P Usyk
    Department of Bioengineering, The Whitaker Institute for Biomedical Engineering, University of California, San Diego, La Jolla 92093 0412, USA
    J Electrocardiol 36:57-61. 2003
    ....
  40. pmc Cardiac myocyte force development during differentiation and maturation
    Jeffrey G Jacot
    Department of Bioengineering, Rice University, and Division of Congenital Heart Surgery, Texas Children s Hospital, Houston, Texas, USA
    Ann N Y Acad Sci 1188:121-7. 2010
    ..These results suggest that extracellular stiffness significantly affects maturation and differentiation of immature ventricular myocytes...
  41. ncbi request reprint Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathy
    Ilka Lorenzen-Schmidt
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0412, USA
    J Mol Cell Cardiol 39:241-50. 2005
    ..These results indicate that the progression to heart failure in the MLPKO model may be driven by diastolic myocardial dysfunction and abnormal passive properties rather than systolic dysfunction...
  42. ncbi request reprint A role for decorin in the remodeling of myocardial infarction
    Sara M Weis
    Whitaker Institute of Biomedical Engineering, University of California, San Diego, La Jolla, CA 92093, USA
    Matrix Biol 24:313-24. 2005
    ..This might contribute to aneurysmal ventricular dilatation, remote hypertrophy, and depressed ventricular function...
  43. pmc Multi-scale modeling of excitation-contraction coupling in the normal and failing heart
    Roy C P Kerckhoffs
    Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4281-2. 2009
    ..We summarize application to human genetic diseases (LQT1 and LQT3) and to modeling of congestive heart failure...
  44. pmc Chronotropic response of cultured neonatal rat ventricular myocytes to short-term fluid shear
    Ilka Lorenzen-Schmidt
    Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0613, USA
    Cell Biochem Biophys 46:113-22. 2006
    ..The results suggest that the beta-adrenergic signaling pathway and integrin activation, which are known to interact, may play an important role in the response mechanism...
  45. pmc Modeling regulation of cardiac KATP and L-type Ca2+ currents by ATP, ADP, and Mg2+
    Anushka Michailova
    Department of Bioengineering, University of California San Diego, La Jolla, CA 92093, USA
    Biophys J 88:2234-49. 2005
    ..The model predictions are in agreement with experimental data measured under normal and a variety of pathological conditions...
  46. pmc Role of diastolic properties in the transition to failure in a mouse model of the cardiac dilatation
    Peter N Costandi
    Dept of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0613, USA
    Am J Physiol Heart Circ Physiol 291:H2971-9. 2006
    ..Though initially compensatory, this process may exhaust itself and consequently transition to a maladaptive course...
  47. ncbi request reprint A more efficient search strategy for aging genes based on connectivity
    Luca Ferrarini
    The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
    Bioinformatics 21:338-48. 2005
    ..g. development) null mutations alone have been very informative. Therefore, in the case of aging the task is larger and the need for a more efficient genetic search strategy is especially strong...
  48. pmc Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart
    Byung Kwan Lim
    Department of Medicine, University of California San Diego, Division of Cardiology, La Jolla, California 92093 0613, USA
    J Clin Invest 118:2758-70. 2008
    ..Furthermore, localization of connexin 45 at the AV-node cell-cell junction and of beta-catenin and ZO-1 at the ventricular intercalated disc are dependent on CAR...
  49. pmc Hypertrophic gene expression induced by chronic stretch of excised mouse heart muscle
    Anna M Raskin
    Department of Bioengineering, University of California San Diego, CA 92093, USA
    Mol Cell Biomech 6:145-59. 2009
    ..Load induced ANP expression was blunted in muscles from muscle-LIM protein knockout mice, in which defective mechanotransduction pathways have been predicted...
  50. pmc An FHL1-containing complex within the cardiomyocyte sarcomere mediates hypertrophic biomechanical stress responses in mice
    Farah Sheikh
    Department of Medicine, UCSD, La Jolla, California 92093, USA
    J Clin Invest 118:3870-80. 2008
    ..These studies shed light on the physiological regulation of the sarcomere in response to hypertrophic stress...
  51. pmc Coupling of adjacent tropomyosins enhances cross-bridge-mediated cooperative activation in a markov model of the cardiac thin filament
    Stuart G Campbell
    Department of Bioengineering, University of California San Diego, La Jolla, California, USA
    Biophys J 98:2254-64. 2010
    ..Without excluding other putative cooperative mechanisms, these findings suggest that structural coupling of adjacent Tm molecules contributes to several properties of cardiac myofilament activation...
  52. ncbi request reprint Cardiac beta-adrenergic signaling: from subcellular microdomains to heart failure
    Jeffrey J Saucerman
    Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Ann N Y Acad Sci 1080:348-61. 2006
    ..Here, we review recent basic insights and novel quantitative approaches that are leading to a more comprehensive understanding of beta-adrenergic signaling and thus motivate new therapeutic strategies for cardiac disease...
  53. ncbi request reprint Integrating metabolomics and phenomics with systems models of cardiac hypoxia
    Jacob D Feala
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Prog Biophys Mol Biol 96:209-25. 2008
    ..Here we present a framework for a systems approach to hypoxia in the cardiac myocyte, starting from nuclear magnetic resonance (NMR) metabolomics, a constraint-based metabolic model, and phenotypic profiles...
  54. ncbi request reprint The nitric oxide scavenger cobinamide profoundly improves survival in a Drosophila melanogaster model of bacterial sepsis
    Kate E Broderick
    Department of Medicine, University of California San Diego, La Jolla 92093 0652, USA
    FASEB J 20:1865-73. 2006
    ..Cobinamide augmented the effect of an antibiotic and was beneficial even in immune-deficient flies. Cobinamide's mechanism of action appeared to be from reducing NO levels and improving cardiac function...
  55. pmc Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes
    Jeffrey J Saucerman
    Department of Bioengineering, Whitaker Institute of Biomedical Engineering, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 103:12923-8. 2006
    ..These findings indicate that combining live-cell FRET imaging and mechanistic computational models can provide quantitative understanding of spatiotemporal signaling...
  56. pmc Flexibility in energy metabolism supports hypoxia tolerance in Drosophila flight muscle: metabolomic and computational systems analysis
    Jacob D Feala
    Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA
    Mol Syst Biol 3:99. 2007
    ..Simulations supported the hypothesis that the ability to flexibly convert pyruvate to these three by-products might convey hypoxia tolerance by improving the ATP/H(+) ratio and efficiency of glucose utilization...
  57. doi request reprint Discovering regulators of the Drosophila cardiac hypoxia response using automated phenotyping technology
    Jacob D Feala
    Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, 0412, La Jolla, CA 92093 0412, USA
    Ann N Y Acad Sci 1123:169-77. 2008
    ..We discuss the possible applications of a genome-wide cardiac phenotype data set in systems biology analyses of hypoxic metabolism, using genome-scale interaction networks and constraint-based metabolic models...
  58. ncbi request reprint Integrative biological modelling in silico
    Andrew D McCulloch
    Department of Bioengineering, The Whitaker Institute of Biomedical Engineering, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Novartis Found Symp 247:4-19; discussion 20-5, 84-90, 244-52. 2002
    ....
  59. pmc Search algorithms as a framework for the optimization of drug combinations
    Diego Calzolari
    Burnham Institute for Medical Research, La Jolla, CA, USA
    PLoS Comput Biol 4:e1000249. 2008
    ..This report also helps to frame a biomedical problem that will benefit from an interdisciplinary effort and suggests a general strategy for its solution...
  60. pmc Effect of stimulation rate, sarcomere length and Ca(2+) on force generation by mouse cardiac muscle
    Bruno D Stuyvers
    University of Calgary, Health Sciences Center, Department of Medicine, Physiology and Biophysics, Alberta, Canada
    J Physiol 544:817-30. 2002
    ..These results may suggest a lower capacity of the SR for buffering Ca(2+), which makes the generation of force in mouse cardiac ventricle more dependent on Ca(2+) entering during action potentials, particularly at high heart rate...
  61. pmc Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center, The Fred Saigh Distinguished Professor, Washington University, Campus Box 1097, Whitaker Hall Room 290B, One Brookings Dr, St Louis, MO 63130 4899, USA
    Circulation 118:1202-11. 2008
    ..The recommendations can be found on the NHLBI Web site at http://www.nhlbi.nih.gov/meetings/workshops/electro.htm...
  62. ncbi request reprint The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy
    Ralph Knoll
    Institute of Molecular Medicine, Department of Medicine, University of California at San Diego, La Jolla 92093, USA
    Cell 111:943-55. 2002
    ..We propose that a Z disc MLP/T-cap complex is a key component of the in vivo cardiomyocyte stretch sensor machinery, and that defects in the complex can lead to human DCM and associated heart failure...
  63. pmc Cell cultures as models of cardiac mechanoelectric feedback
    Yibing Zhang
    Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD 21205, USA
    Prog Biophys Mol Biol 97:367-82. 2008
    ....
  64. ncbi request reprint Modeling beta-adrenergic control of cardiac myocyte contractility in silico
    Jeffrey J Saucerman
    Department of Bioengineering, University of California, San Diego, La Jolla, California 92093 0412, USA
    J Biol Chem 278:47997-8003. 2003
    ..By performing systems analysis, the consequences of molecular perturbations in the beta-adrenergic signaling network may be understood within the context of integrative cellular physiology...
  65. ncbi request reprint Nonhomogeneous deformation in the anterior leaflet of the mitral valve
    Ling Chen
    Department of Mechanical Engineering, San Diego State University, San Diego, CA 92182 1323, USA
    Ann Biomed Eng 32:1599-606. 2004
    ..This information can be used to better understand how the valve deforms under physiological loading, and to help design treatments for valve problems, such as mitral regurgitation...
  66. ncbi request reprint Microstructured cocultures of cardiac myocytes and fibroblasts: a two-dimensional in vitro model of cardiac tissue
    Patrizia Camelliti
    University Laboratory of Physiology, Oxford, OX1 3PT, UK
    Microsc Microanal 11:249-59. 2005
    ..We conclude that structured cocultures of cardiomyocytes and fibroblasts mimic in vivo ventricular tissue organization and provide a novel tool for in vitro research into cardiac electromechanical function...
  67. pmc Structural and functional roles of desmin in mouse skeletal muscle during passive deformation
    Sameer B Shah
    Departments of Bioengineering and Orthopaedics, Biomedical Sciences Graduate Group, University of California and Veterans Administration Medical Centers, San Diego, California 92161, USA
    Biophys J 86:2993-3008. 2004
    ..Finally, linkage of desmin intermediate filaments to muscle nuclei was strongly suggested based on extensive loss of nuclei positioning in the absence of desmin during passive fiber loading...
  68. ncbi request reprint Left ventricular form and function: scientific priorities and strategic planning for development of new views of disease
    Gerald D Buckberg
    University of California, Los Angeles, USA
    Circulation 110:e333-6. 2004
  69. ncbi request reprint Micropatterned cell cultures on elastic membranes as an in vitro model of myocardium
    Patrizia Camelliti
    Department of Physiology, Anatomy and Genetics, Parks Road, Oxford OX1 3PT, UK
    Nat Protoc 1:1379-91. 2006
    ..The entire process from fabrication of the micropatterned silicon metal wafers to casting of silicone molds, microfluidic patterning and cell isolation and seeding takes approximately 7 days...
  70. ncbi request reprint Myocyte shearing, myocardial sheets, and microtubules
    Andrew D McCulloch
    Circ Res 98:1-3. 2006
  71. ncbi request reprint Acetylcholine-induced shortening of the epicardial action potential duration may increase repolarization gradients and LQT3 arrhythmic risk
    Sarah N Flaim
    Oxford University Computing Laboratory, University of Oxford, Oxford, United Kingdom
    J Electrocardiol 40:S66-9. 2007
    ..Our results suggest that ACh-mediated effects on epicardial myocytes may amplify already steep repolarisation gradients in the mammalian left ventricular wall of LQT3 patients and consequently increase the risk of arrhythmia formation...
  72. pmc The role of mechanoelectric feedback in vulnerability to electric shock
    Weihui Li
    Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, USA
    Prog Biophys Mol Biol 97:461-78. 2008
    ....
  73. ncbi request reprint New multi-cue bioreactor for tissue engineering of tubular cardiovascular samples under physiological conditions
    Andrew D McCulloch
    Centre for Tissue Engineering Research, Department of Biomedical Sciences, University of Westminster, London, United Kingdom
    Tissue Eng 10:565-73. 2004
    ..The MCB represents a versatile model that will enable the development of tissue engineering not only for cardiovascular tissue, but for all tubular tissues such as esophageal, tracheal, and bronchial systems...

Research Grants3

  1. Multi-Scale Modeling of the Failing Heart for Cardiac Rysynchronization Therapy
    Andrew D McCulloch; Fiscal Year: 2010
    ..The models can then be used to predict the outcome - and thus to improve the number of patients to respond - and optimize this pacemaker therapy for patients. ..
  2. Three-Dimentional Micropatterned Cardiac Tissue Cultures
    Andrew McCulloch; Fiscal Year: 2004
    ..abstract_text> ..
  3. Multi-Scale Modeling of the Failing Heart for Cardiac Rysynchronization Therapy
    Andrew McCulloch; Fiscal Year: 2009
    ..The models can then be used to predict the outcome - and thus to improve the number of patients to respond - and optimize this pacemaker therapy for patients. ..