J T McCracken

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Effectiveness and tolerability of open label olanzapine in children and adolescents with Tourette syndrome
    James T McCracken
    Division of Child and Adolescent Psychiatry, UCLA Neuropsychiatric Institute and David Geffen School of Medicine, Los Angeles, California 90024 1759, USA
    J Child Adolesc Psychopharmacol 18:501-8. 2008
  2. ncbi request reprint Safety issues with drug therapies for autism spectrum disorders
    James T McCracken
    Neuropsychiatric Institute, University of California, Los Angeles, CA, USA
    J Clin Psychiatry 66:32-7. 2005
  3. ncbi request reprint Analog classroom assessment of a once-daily mixed amphetamine formulation, SLI381 (Adderall XR), in children with ADHD
    James T McCracken
    Department of Psychiatry and Biobehavioral Sciences, Division of Child andAdolescent Psychiatry, UCLA Neuropsychiatric Institute, Los Angeles, CA 90024 1759, USA
    J Am Acad Child Adolesc Psychiatry 42:673-83. 2003
  4. ncbi request reprint Elevated thyroid indices in children and adolescents with obsessive-compulsive disorder: effects of clomipramine treatment
    James T McCracken
    UCLA Neuropsychiatric Institute, Los Angeles, California 90024 1759, USA
    J Child Adolesc Psychopharmacol 15:581-7. 2005
  5. ncbi request reprint Evidence for linkage of a tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4) with attention deficit hyperactivity disorder (ADHD)
    J T McCracken
    Department of Psychiatry and Biobehavioral Scienes, UCLA Neuropsychiatric Institute, Mental Retardation Research Center, UCLA School of Medicine, Los Angeles, CA 90024 1759, USA
    Mol Psychiatry 5:531-6. 2000
  6. ncbi request reprint Childhood and early-onset anxiety: treatment and biomarker studies
    James T McCracken
    Division of Child and Adolescent Psychiatry, UCLA Neuropsychiatric Institute, Los Angeles, CA 90024, USA
    J Clin Psychiatry 63:8-11. 2002
  7. ncbi request reprint Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5
    V Kustanovich
    Department of Human Genetics, Division of Child and Adolescent Psychiatry, UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Mol Psychiatry 9:711-7. 2004
  8. pmc Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder
    Ake T Lu
    Department of Human Genetics, University of California, Los Angeles, California, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1488-94. 2008
  9. pmc Effects of methamphetamine abuse and serotonin transporter gene variants on aggression and emotion-processing neurocircuitry
    D E Payer
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
    Transl Psychiatry 2:e80. 2012
  10. ncbi request reprint Medial temporal lobe in childhood-onset schizophrenia
    J G Levitt
    Department of Psychiatry, UCLA Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    Psychiatry Res 108:17-27. 2001

Research Grants

  1. OCD Collaborative Genetics Association Study
    James T McCracken; Fiscal Year: 2010
  2. Drug Response in Pediatric Psychopharmacology
    James McCracken; Fiscal Year: 2005
  3. 3/4-RUPP Autism Network: Guanfacine for the Treatment of Hyperactivity in PDD
    James T McCracken; Fiscal Year: 2010
  4. OCD Collaborative Genetics Association Study
    James McCracken; Fiscal Year: 2009
  5. OCD Collaborative Genetics Association Study
    James McCracken; Fiscal Year: 2007
  6. Follow up of the PATS sample
    James McCracken; Fiscal Year: 2007
  7. Training The Science of Child Mental Health Treatment
    James McCracken; Fiscal Year: 2007

Collaborators

Detail Information

Publications93

  1. pmc Effectiveness and tolerability of open label olanzapine in children and adolescents with Tourette syndrome
    James T McCracken
    Division of Child and Adolescent Psychiatry, UCLA Neuropsychiatric Institute and David Geffen School of Medicine, Los Angeles, California 90024 1759, USA
    J Child Adolesc Psychopharmacol 18:501-8. 2008
    ..Secondary aims included assessing the response of TS-associated disruptive behaviors to olanzapine exposure...
  2. ncbi request reprint Safety issues with drug therapies for autism spectrum disorders
    James T McCracken
    Neuropsychiatric Institute, University of California, Los Angeles, CA, USA
    J Clin Psychiatry 66:32-7. 2005
    ..Monitoring the safety and tolerability of drugs used in patients with these disorders should minimize the burden of side effects and optimize treatment outcome...
  3. ncbi request reprint Analog classroom assessment of a once-daily mixed amphetamine formulation, SLI381 (Adderall XR), in children with ADHD
    James T McCracken
    Department of Psychiatry and Biobehavioral Sciences, Division of Child andAdolescent Psychiatry, UCLA Neuropsychiatric Institute, Los Angeles, CA 90024 1759, USA
    J Am Acad Child Adolesc Psychiatry 42:673-83. 2003
    ..Secondary objectives included examination of the time course, pharmacokinetic, and pharmacodynamic properties of SLI381...
  4. ncbi request reprint Elevated thyroid indices in children and adolescents with obsessive-compulsive disorder: effects of clomipramine treatment
    James T McCracken
    UCLA Neuropsychiatric Institute, Los Angeles, California 90024 1759, USA
    J Child Adolesc Psychopharmacol 15:581-7. 2005
    ....
  5. ncbi request reprint Evidence for linkage of a tandem duplication polymorphism upstream of the dopamine D4 receptor gene (DRD4) with attention deficit hyperactivity disorder (ADHD)
    J T McCracken
    Department of Psychiatry and Biobehavioral Scienes, UCLA Neuropsychiatric Institute, Mental Retardation Research Center, UCLA School of Medicine, Los Angeles, CA 90024 1759, USA
    Mol Psychiatry 5:531-6. 2000
    ..These data add further support for the role of DRD4 variants conferring increased risk for ADHD, and imply that additional studies of DRD4 and other related genes are needed...
  6. ncbi request reprint Childhood and early-onset anxiety: treatment and biomarker studies
    James T McCracken
    Division of Child and Adolescent Psychiatry, UCLA Neuropsychiatric Institute, Los Angeles, CA 90024, USA
    J Clin Psychiatry 63:8-11. 2002
    ..Significant progress is being made in this important clinical area that should translate to improved outcomes through refined diagnosis and empirically tested treatments...
  7. ncbi request reprint Transmission disequilibrium testing of dopamine-related candidate gene polymorphisms in ADHD: confirmation of association of ADHD with DRD4 and DRD5
    V Kustanovich
    Department of Human Genetics, Division of Child and Adolescent Psychiatry, UCLA School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Mol Psychiatry 9:711-7. 2004
    ..240) allele of the promoter polymorphism emerge as the two DNA variants showing a significant association in this large sample of predominantly multiplex families with ADHD, with estimated GRRs of 1.7 and 1.37, respectively...
  8. pmc Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorder
    Ake T Lu
    Department of Human Genetics, University of California, Los Angeles, California, USA
    Am J Med Genet B Neuropsychiatr Genet 147:1488-94. 2008
    ..01 for C-G). These observations require replication, however, they suggest that the CNR1 gene may be a risk factor for ADHD and possibly PTSD, and that this gene warrants further investigation for a role in neuropsychiatric disorders...
  9. pmc Effects of methamphetamine abuse and serotonin transporter gene variants on aggression and emotion-processing neurocircuitry
    D E Payer
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
    Transl Psychiatry 2:e80. 2012
    ....
  10. ncbi request reprint Medial temporal lobe in childhood-onset schizophrenia
    J G Levitt
    Department of Psychiatry, UCLA Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024, USA
    Psychiatry Res 108:17-27. 2001
    ..These findings are consistent with previous reports of at least initial sparing of temporal lobe regions in childhood-onset schizophrenia...
  11. ncbi request reprint Temperament and character profiles and the dopamine D4 receptor gene in ADHD
    Deborah E Lynn
    UCLA Department of Child and Adolescent Psychiatry, 10850 Wilshire Blvd, Suite 200, Los Angeles, CA 90024, USA
    Am J Psychiatry 162:906-13. 2005
    ..This study was designed to investigate the link among attention deficit hyperactivity disorder (ADHD) in adults, novelty-seeking temperament, and the 48-base pair (bp) dopamine D4 receptor (DRD4) gene variant...
  12. ncbi request reprint Relationship of family environment and parental psychiatric diagnosis to impairment in ADHD
    Leah J Pressman
    Department of Psychiatry, UCLA Semel Institute, Los Angeles, CA 90095 1759, USA
    J Am Acad Child Adolesc Psychiatry 45:346-54. 2006
    ..The purpose of the present study was to examine the links among family environment, parental psychiatric diagnosis, and child impairment within a sample of ADHD-affected sibling pairs (ASPs) ages 5 to 18 years...
  13. ncbi request reprint A laboratory school comparison of mixed amphetamine salts extended release (Adderall XR) and atomoxetine (Strattera) in school-aged children with attention deficit/hyperactivity disorder
    Sharon B Wigal
    Child Development Center, University of California, Irvine, CA 92612, USA
    J Atten Disord 9:275-89. 2005
    ..001). Adverse events were similar for both treatment groups. The extended time course of action and greater therapeutic efficacy of MAS XR suggests that it is more effective than atomoxetine in children with ADHD...
  14. ncbi request reprint Executive functioning among Finnish adolescents with attention-deficit/hyperactivity disorder
    Sandra K Loo
    University of California, Los Angeles, CA 90095, USA
    J Am Acad Child Adolesc Psychiatry 46:1594-604. 2007
    ..The present study examined cognitive functioning in a population sample of adolescents with and without attention-deficit/hyperactivity disorder (ADHD) from the Northern Finland Birth Cohort 1986...
  15. ncbi request reprint Biased paternal transmission of SNAP-25 risk alleles in attention-deficit hyperactivity disorder
    V Kustanovich
    Department of Human Genetics, UCLA School of Medicine, University of California, Los Angeles, USA
    Mol Psychiatry 8:309-15. 2003
    ..027) when paternal transmissions were evaluated...
  16. ncbi request reprint Genome-wide scan of reading ability in affected sibling pairs with attention-deficit/hyperactivity disorder: unique and shared genetic effects
    S K Loo
    Center for Neurobehavioral Genetics, University of California, Los Angeles, USA
    Mol Psychiatry 9:485-93. 2004
    ..The eventual identification of genes underlying these unique and shared linkages may increase our understanding of ADHD, RD and the relationship between the two...
  17. ncbi request reprint Familial clustering of symptoms and disruptive behaviors in multiplex families with attention-deficit/hyperactivity disorder
    S L Smalley
    Department of Psychiatry, UCLA School of Medicine 90024 1759, USA
    J Am Acad Child Adolesc Psychiatry 39:1135-43. 2000
    ..To examine familial clustering of attention-deficit/hyperactivity disorder (ADHD), ADHD subtypes, symptoms, and oppositional behaviors in affected sibling pairs (ASPs) and their parents...
  18. ncbi request reprint Mood stabilizers in the treatment of juvenile bipolar disorder. Advances and controversies
    P A Davanzo
    Department of Psychiatry, University of California Los Angeles, USA
    Child Adolesc Psychiatr Clin N Am 9:159-82. 2000
    ....
  19. ncbi request reprint REM sleep in depression is influenced by ethnicity
    R E Poland
    Department of Psychiatry, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Psychiatry Res 88:95-105. 1999
    ..Because many antidepressants suppress REM sleep, the differences in baseline REM sleep observed might be related to the greater sensitivity of some ethnic-minority depressed patients to pharmacotherapy...
  20. ncbi request reprint Atypical brain laterality in adults with ADHD during dichotic listening for emotional intonation and words
    T Sigi Hale
    Division of Child and Adolescent Psychiatry, UCLA Neuropsychiatric Institute and David Geffen School of Medicine, 760 Westwood Plaza, Room 48 270, Los Angeles, CA 90024, USA
    Neuropsychologia 44:896-904. 2006
    ..We posit that these hemispheric differences were due to management or use of available cognitive resources rather than inherent capacity...
  21. pmc Cortical activity patterns in ADHD during arousal, activation and sustained attention
    Sandra K Loo
    Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, United States
    Neuropsychologia 47:2114-9. 2009
    ..The goal of the present study is to test whether there are Attention-Deficit Hyperactivity Disorder (ADHD)-related differences in brain electrical activity patterns across arousal, activation and vigilance states...
  22. ncbi request reprint Long-term tolerability and effectiveness of once-daily mixed amphetamine salts (Adderall XR) in children with ADHD
    James J McGough
    Division of Child and Adolescent Psychiatry, UCLA Neuropsychiatric Institute, Los Angeles, CA, USA
    J Am Acad Child Adolesc Psychiatry 44:530-8. 2005
    ..To evaluate the long-term tolerability and effectiveness of extended-release mixed amphetamine salts (MAS XR; Adderall XR) in children with attention-deficit/hyperactivity disorder (ADHD)...
  23. ncbi request reprint Psychiatric comorbidity in adult attention deficit hyperactivity disorder: findings from multiplex families
    James J McGough
    Center for Neurobehavioral Genetics, David Geffen School of Medicine, Suite 1414, 300 UCLA Medical Plaza, Los Angeles, CA 90095, USA
    Am J Psychiatry 162:1621-7. 2005
    ..Patterns of psychiatric comorbidity were assessed in adults with and without attention deficit hyperactivity disorder (ADHD) identified through a genetic study of families containing multiple children with ADHD...
  24. pmc CBCL pediatric bipolar disorder profile and ADHD: comorbidity and quantitative trait loci analysis
    James J McGough
    Division of Child and Adolescent Psychiatry, UCLA Semel Institute for Neuroscience and Human Behavior and David Geffen School of Medicine
    J Am Acad Child Adolesc Psychiatry 47:1151-7. 2008
    ..We used CBCL-PBD profiles to distinguish patterns of comorbidity and to search for quantitative trait loci in a genomewide scan in a sample of multiple affected ADHD sibling pairs...
  25. pmc Correlates of accommodation of pediatric obsessive-compulsive disorder: parent, child, and family characteristics
    Tara S Peris
    Division of Child and Adolescent Psychiatry, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90095, USA
    J Am Acad Child Adolesc Psychiatry 47:1173-81. 2008
    ..This study conducted exploratory analyses of parent-, child-, and family-level correlates of family accommodation, considering both behavioral and affective components of the response...
  26. pmc Decreased callosal thickness in attention-deficit/hyperactivity disorder
    Eileen Luders
    Laboratory of Neuro Imaging, Department of Neurology, University of California at Los Angeles School of Medicine, Los Angeles, California 90095 7334, USA
    Biol Psychiatry 65:84-8. 2009
    ..One of the most replicated alterations is a significantly smaller corpus callosum (CC), for which conflicting reports exist with respect to the affected callosal segments...
  27. pmc Gene variants of brain dopamine pathways and smoking-induced dopamine release in the ventral caudate/nucleus accumbens
    Arthur L Brody
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    Arch Gen Psychiatry 63:808-16. 2006
    ..Preclinical studies demonstrate that nicotine administration leads to dopamine release in the ventral striatum. However, human studies reveal considerable interindividual variability in the extent of smoking-induced dopamine release...
  28. ncbi request reprint Prevalence and psychiatric comorbidity of attention-deficit/hyperactivity disorder in an adolescent Finnish population
    Susan L Smalley
    Semel Institute, University of California, Los Angeles, CA 90095, USA
    J Am Acad Child Adolesc Psychiatry 46:1575-83. 2007
    ..The purpose of the study was to estimate the prevalence of attention-deficit/hyperactivity disorder (ADHD) and its clinical characteristics in the Northern Finland Birth Cohort 1986...
  29. ncbi request reprint Neurocognitive correlates of child obsessive compulsive disorder and Tourette syndrome
    SUSANNA W CHANG
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095, USA
    J Clin Exp Neuropsychol 29:724-33. 2007
    ..TS findings were less robust and may be construed tentatively as suggestive of executive function deficits. Future research is needed to delineate the influence of development on neurocognitive deficits associated with OCD and TS...
  30. ncbi request reprint Atypical brain activation during simple & complex levels of processing in adult ADHD: an fMRI study
    T Sigi Hale
    Division of Child and Adolescent Psychiatry, Neuropsychiatric Institute and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Atten Disord 11:125-40. 2007
    ..Executive dysfunction in ADHD is well supported. However, recent studies suggest that more fundamental impairments may be contributing. We assessed brain function in adults with ADHD during simple and complex forms of processing...
  31. ncbi request reprint The association of DRD4 and novelty seeking is found in a nonhuman primate model
    Julia N Bailey
    Center for Primate Neuroethology, Semel Institute for Neuroscience and Human Behavior, University of California at Los Angeles, Los Angeles, California 90095, USA
    Psychiatr Genet 17:23-7. 2007
    ..The objective of this study was to test the generality of the association in a captive nonhuman primate population of known history, using objective methods for assessing novelty seeking and a pedigree-based association design...
  32. pmc Possible influence of variant of the P-glycoprotein gene (MDR1/ABCB1) on clinical response to guanfacine in children with pervasive developmental disorders and hyperactivity
    James T McCracken
    Research Units on Pediatric Psychopharmacology Autism Network, University of California at Los Angeles, Los Angeles, CA 90024 1759, USA
    J Child Adolesc Psychopharmacol 20:1-5. 2010
    ....
  33. ncbi request reprint Abnormal development of the anterior cingulate in childhood-onset schizophrenia: a preliminary quantitative MRI study
    Renée K Marquardt
    Department of Psychiatry, UCLA Neuropsychiatric Institute, Los Angeles, CA 90024, USA
    Psychiatry Res 138:221-33. 2005
    ..These structural differences may relate to the well-described cognitive deficits these children display, and to the cardinal symptoms of schizophrenia...
  34. doi request reprint Monoamine oxidase a and catechol-o-methyltransferase functional polymorphisms and the placebo response in major depressive disorder
    Andrew F Leuchter
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, 760 Westwood Plaza, Rm 37 452, Los Angeles, CA 90024 1759, USA
    J Clin Psychopharmacol 29:372-7. 2009
    ..These findings support the hypothesis that genetic polymorphisms modulating monoaminergic tone are related to degree of placebo responsiveness in major depressive disorder...
  35. pmc Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autism
    Susan L Smalley
    Center for Neurobehavioral Genetics and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90024USA
    Am J Hum Genet 71:959-63. 2002
    ..These findings suggest that variations in a gene on 16p13 may contribute to common deficits found in both ADHD and autism...
  36. ncbi request reprint Open trial of cognitive behavior therapy for childhood obsessive-compulsive disorder
    John Piacentini
    Department of Psychiatry and Biobehavioral Sciences, Division of Child and Adolescent Psychiatry, UCLA School of Medicine, Los Angeles, CA, USA
    J Anxiety Disord 16:207-19. 2002
    ..Controlled trials are needed to provide a more rigorous test of this treatment approach and provide better information regarding potential mediators and moderators of outcome...
  37. ncbi request reprint Cortical sulcal maps in autism
    Jennifer G Levitt
    Department of Psychiatry, UCLA Neuropsychiatric Institute, 760 Westwood Plaza, Los Angeles, CA 90024 1759, USA
    Cereb Cortex 13:728-35. 2003
    ..These findings may indicate delayed maturation in autistic subjects in these brain regions involved in functions including working memory, emotion processing, language and eye gaze...
  38. pmc Clinical and cognitive correlates of depressive symptoms among youth with obsessive compulsive disorder
    Tara S Peris
    UCLA Semel Institute for Neuroscience and Human Behavior, CA, USA
    J Clin Child Adolesc Psychol 39:616-26. 2010
    ..Depressive symptoms were also linked to older age and more severe OCD. Low perceived control and self-competence and high OCD severity independently predicted depression scores...
  39. pmc Atypical EEG beta asymmetry in adults with ADHD
    T Sigi Hale
    Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
    Neuropsychologia 48:3532-9. 2010
    ..The current study investigates whether this ABL characteristic occurs in adults with ADHD absent comorbid language impairment...
  40. ncbi request reprint Pharmacokinetics of SLI381 (ADDERALL XR), an extended-release formulation of Adderall
    James J McGough
    Department of Psychiatry and Biobehavioral Sciences, Division of Child and Adolescent Psychiatry, UCLA Neuropsychiatric Institute, Los Angeles, USA
    J Am Acad Child Adolesc Psychiatry 42:684-91. 2003
    ..To assess the pharmacokinetic (PK) properties of a single daily dose of Adderall (mixed amphetamine salts) and the extended-release formulation, SLI381 (ADDERALL XR), in pediatric attention-deficit/hyperactivity disorder (ADHD)...
  41. pmc Familial clustering and DRD4 effects on electroencephalogram measures in multiplex families with attention deficit/hyperactivity disorder
    Sandra K Loo
    Semel Institute for Neuroscience and Human Behavior and David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    J Am Acad Child Adolesc Psychiatry 49:368-77. 2010
    ....
  42. ncbi request reprint Proton magnetic resonance spectroscopic imaging of the brain in childhood autism
    Jennifer G Levitt
    Department of Psychiatry and Biobehavioral Sciences, Neuropsychiatric Institute, Los Angeles, California, USA
    Biol Psychiatry 54:1355-66. 2003
    ....
  43. pmc Atypical alpha asymmetry in adults with ADHD
    T Sigi Hale
    Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience and Human Behavior, United States
    Neuropsychologia 47:2082-8. 2009
    ..The current study explores whether increased rightward alpha asymmetry is also evident in adults with ADHD...
  44. doi request reprint Comparative effectiveness of biomarkers and clinical indicators for predicting outcomes of SSRI treatment in Major Depressive Disorder: results of the BRITE-MD study
    Andrew F Leuchter
    Semel Institute for Neuroscience and Human Behavior at UCLA, Los Angeles, CA 90024 1759, USA
    Psychiatry Res 169:124-31. 2009
    ..Logistic regression showed that the ATR and early Ham-D(17) changes were additive predictors of response, but the ATR was the only significant predictor of remission. Future studies should replicate these results prior to clinical use...
  45. pmc Widespread cortical thinning is a robust anatomical marker for attention-deficit/hyperactivity disorder
    Katherine L Narr
    David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    J Am Acad Child Adolesc Psychiatry 48:1014-22. 2009
    ....
  46. pmc ADHD familial loading and abnormal EEG alpha asymmetry in children with ADHD
    T Sigi Hale
    Division of Child and Adolescent Psychiatry and Center for Neurobehavioral Genetics at the UCLA Semel Institute, 760 Westwood Plaza, Room 47 448, Los Angeles, CA 90095, United States
    J Psychiatr Res 44:605-15. 2010
    ..Previous studies have shown increased rightward alpha asymmetry in ADHD. We tested whether this was more pronounced in ADHD children with increased ADHD family loading...
  47. ncbi request reprint Prevalence and description of selective mutism in a school-based sample
    R Lindsey Bergman
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, USA
    J Am Acad Child Adolesc Psychiatry 41:938-46. 2002
    ..To examine the prevalence of selective mutism (SM) in a public school sample and compare the functioning and symptoms of children with SM to age- and gender-matched unaffected children...
  48. ncbi request reprint 1H MRSI evidence of metabolic abnormalities in childhood-onset schizophrenia
    JOSEPH O'NEILL
    Division of Child and Adolescent Psychiatry, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Neuroimage 21:1781-9. 2004
    ..Low NAA may reflect diminished neuronal integrity...
  49. pmc Moderation of antipsychotic-induced weight gain by energy balance gene variants in the RUPP autism network risperidone studies
    E L Nurmi
    Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute, Los Angeles, CA 90024, USA
    Transl Psychiatry 3:e274. 2013
    ..This study highlights compelling directions for further exploration of the pharmacogenetic basis of this concerning multifactorial adverse event...
  50. pmc Positive effects of methylphenidate on hyperactivity are moderated by monoaminergic gene variants in children with autism spectrum disorders
    J T McCracken
    Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Semel Institute for Neuroscience, Los Angeles, CA, USA
    Pharmacogenomics J 14:295-302. 2014
    ..For this first MPH pharmacogenetic study in children with ASD, multiple monoaminergic gene variants may help explain individual differences in MPH's efficacy and tolerability. ..
  51. pmc A genomewide scan for attention-deficit/hyperactivity disorder in an extended sample: suggestive linkage on 17p11
    Matthew N Ogdie
    Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA
    Am J Hum Genet 72:1268-79. 2003
    ..Interestingly, both regions, as well as 5p13, have been highlighted in genomewide scans for autism...
  52. pmc Potential adverse effects of amphetamine treatment on brain and behavior: a review
    S M Berman
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024 1759, USA
    Mol Psychiatry 14:123-42. 2009
    ..Finally, identification of the biological factors that confer risk and those that offer protection is also needed to better specify the parameters of safe, long-term, therapeutic administration of amphetamines to adults...
  53. ncbi request reprint Assessment of attention deficit hyperactivity disorder: a review of recent literature
    J J McGough
    Division of Child and Adolescent Psychiatry, UCLA Neuropsychiatric Institute, Los Angeles, California, USA
    Curr Opin Pediatr 12:319-24. 2000
    ....
  54. ncbi request reprint Risperidone in children with autism and serious behavioral problems
    James T McCracken
    University of California, Los Angeles, USA
    N Engl J Med 347:314-21. 2002
    ..However, data on the safety and efficacy of atypical antipsychotic agents in children are limited...
  55. pmc Attention deficit hyperactivity disorder: fine mapping supports linkage to 5p13, 6q12, 16p13, and 17p11
    Matthew N Ogdie
    Human Genetics, University of California Los Angeles, Los Angeles, CA, USA
    Am J Hum Genet 75:661-8. 2004
    ..The refinement of linkage within each of these regions lays the foundation for subsequent investigations using association methods to detect risk genes of moderate effect size...
  56. ncbi request reprint Mental health problems and service use among female juvenile offenders: their relationship to criminal history
    S H Kataoka
    Department of Psychiatry, University of California, Los Angeles 90095-1736, USA
    J Am Acad Child Adolesc Psychiatry 40:549-55. 2001
    ..Interventions for these high-risk youths should include an assessment for substance use disorders because of the association of recidivism and substance use problems in this population...
  57. ncbi request reprint Mapping cortical asymmetry and complexity patterns in normal children
    R E Blanton
    Laboratory of Neuro Imaging, Department of Neurology, Division of Brain Mapping, UCLA, School of Medicine, Los Angeles, CA 90095-1769, USA
    Psychiatry Res 107:29-43. 2001
    ..More studies in a larger sample set and/or longitudinal design are needed to address the issues of normal individual variation and sulcal development...
  58. doi request reprint Association of SLC6A4 variants with obsessive-compulsive disorder in a large multicenter US family study
    E Voyiaziakis
    Department of Psychiatry and the Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Mol Psychiatry 16:108-20. 2011
    ..A noteworthy lack of association at the LPR, LPR-rs25531 and rare 425V variants suggests that hypotheses about OCD risk need revision to accommodate these new findings, including a possible gender effect...
  59. ncbi request reprint Relationship between ethnicity and sleep patterns in normal controls: implications for psychopathology and treatment
    U Rao
    Department of Psychiatry, Harbor UCLA Medical Center, Torrance, CA, USA
    J Psychiatr Res 33:419-26. 1999
    ....
  60. ncbi request reprint Gender differences in the left inferior frontal gyrus in normal children
    Rebecca E Blanton
    Laboratory of Neuro Imaging, Department of Neurology, Division of Brain Mapping, UCLA School of Medicine, Los Angeles, CA 90095 1769, USA
    Neuroimage 22:626-36. 2004
    ....
  61. pmc Further development of YBOCS dimensions in the OCD Collaborative Genetics study: symptoms vs. categories
    Anthony Pinto
    Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital, Providence, RI 02906, USA
    Psychiatry Res 160:83-93. 2008
    ..The results support investigation of this multidimensional model in OCD genetic linkage studies...
  62. ncbi request reprint Risperidone and adaptive behavior in children with autism
    Susan K Williams
    Yale University, New Haven, CT 06520 7900, USA
    J Am Acad Child Adolesc Psychiatry 45:431-9. 2006
    ..To evaluate the impact of risperidone on adaptive behavior in children with autistic disorder who have serious behavior problems and to examine different methods of scoring the Vineland Adaptive Behavior Scales to measure change...
  63. pmc The OCD collaborative genetics study: methods and sample description
    Jack F Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7228, USA
    Am J Med Genet B Neuropsychiatr Genet 141:201-7. 2006
    ....
  64. ncbi request reprint Acute and long-term safety and tolerability of risperidone in children with autism
    Michael G Aman
    The Nisonger Center, Ohio State University, Columbus, Ohio 43210 1296, USA
    J Child Adolesc Psychopharmacol 15:869-84. 2005
    ..Most AEs were mild to moderate and failed to interfere with therapeutic changes; there were no unanticipated AEs. The side effects of most concern were somnolence and weight gain...
  65. ncbi request reprint Assessment of the integrity of study blindness in a pediatric clinical trial of risperidone
    Benedetto Vitiello
    Division of Services and Intervention Research, National Institute of Mental Health, Bethesda, MD 20892 9633, USA
    J Clin Psychopharmacol 25:565-9. 2005
    ..The blindness of clinical evaluators and parents was examined in a clinical trial of risperidone in autism...
  66. ncbi request reprint Risperidone for the core symptom domains of autism: results from the study by the autism network of the research units on pediatric psychopharmacology
    Christopher J McDougle
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4800, USA
    Am J Psychiatry 162:1142-8. 2005
    ..The authors report on whether risperidone improves the core symptoms of autism, social and communication impairment and repetitive and stereotyped behavior...
  67. ncbi request reprint Research knowledge among parents of children participating in a randomized clinical trial
    Benedetto Vitiello
    Child and Adolescent Treatment and Preventive Intervention Research Branch, National Institute of Mental Health, Bethesda, MD 20892 9633, USA
    J Am Acad Child Adolesc Psychiatry 44:145-9. 2005
    ..Parental permission is required for child research, but parents' understanding of research aims and procedures has not been well documented. Parental research knowledge was assessed during a clinical trial in autism...
  68. ncbi request reprint Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study
    Jack Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, School of Medicine, 600 N Wolfe St, Meyer 4 181, Baltimore, MD 21287 7228, USA
    Am J Psychiatry 164:493-9. 2007
    ..The objective of this study was to determine whether there are chromosomal regions specifically linked to compulsive hoarding behavior in families with obsessive-compulsive disorder...
  69. ncbi request reprint Developing methodologies for monitoring long-term safety of psychotropic medications in children: report on the NIMH conference, September 25, 2000
    Laurence L Greenhill
    New York State Psychiatric Institute, New York 10032, USA
    J Am Acad Child Adolesc Psychiatry 42:651-5. 2003
    ..To improve the methods for long-term assessment of drug-associated side effects and advance knowledge of the safety profile of psychotropic medications in children and adolescents...
  70. pmc A genomewide scan for loci involved in attention-deficit/hyperactivity disorder
    Simon E Fisher
    Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, United Kingdom
    Am J Hum Genet 70:1183-96. 2002
    ..Two of the regions highlighted in the present study, 2q24 and 16p13, coincided with the top linkage peaks reported by a recent genome-scan study of autistic sib pairs...
  71. ncbi request reprint Effects of short- and long-term risperidone treatment on prolactin levels in children with autism
    George M Anderson
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 61:545-50. 2007
    ..The effects of short- and long-term risperidone treatment on serum prolactin were assessed in children and adolescents with autism...
  72. ncbi request reprint A prospective open trial of guanfacine in children with pervasive developmental disorders
    Lawrence Scahill
    Yale Child Study Center, P O Box 207900, New Haven, CT 06520, USA
    J Child Adolesc Psychopharmacol 16:589-98. 2006
    ..A common complaint for children with pervasive developmental disorder (PDD) is hyperactivity. The purpose of this pilot study was to gather preliminary information on the efficacy of guanfacine in children with PDD and hyperactivity...
  73. ncbi request reprint Demographic and clinical characteristics associated with treatment status in family members with obsessive-compulsive disorder
    Bernadette Cullen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Depress Anxiety 25:218-24. 2008
    ..Clinical factors are predominant in predicting treatment status in family members with OCD. Although the mean duration from onset of symptoms to treatment was long, younger family members appear to receive treatment sooner...
  74. ncbi request reprint Adult attention deficit hyperactivity disorder: moving beyond DSM-IV
    James J McGough
    Am J Psychiatry 163:1673-5. 2006
  75. ncbi request reprint Parent-rated anxiety symptoms in children with pervasive developmental disorders: frequency and association with core autism symptoms and cognitive functioning
    Denis G Sukhodolsky
    The Child Study Center, Yale University, 230 South Frontage Road, New Haven, CT 06520, USA
    J Abnorm Child Psychol 36:117-28. 2008
    ..Limited data are available on the prevalence of anxiety in these children. We examined frequency and correlates of parent-rated anxiety symptoms in a large sample of children with PDD...
  76. ncbi request reprint Dietary status and impact of risperidone on nutritional balance in children with autism: a pilot study
    Ronald L Lindsay
    Children s Health Center of St Joseph s Hospital and Medical Center, Arizona 85013, USA
    J Intellect Dev Disabil 31:204-9. 2006
    ..Risperidone may be effective in improving tantrums, aggression, or self-injurious behaviour in children with autism, but often leads to weight gain...
  77. ncbi request reprint Children's Yale-Brown Obsessive Compulsive Scale modified for pervasive developmental disorders
    Lawrence Scahill
    Yale Child Study Center, Yale University, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 45:1114-23. 2006
    ..To examine the psychometric properties of the Children's Yale-Brown Obsessive Compulsive Scales (CYBOCS) modified for pervasive developmental disorders (PDDs)...
  78. ncbi request reprint Atomoxetine treatment of ADHD in children with comorbid Tourette syndrome
    Thomas J Spencer
    Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114 2696, USA
    J Atten Disord 11:470-81. 2008
    ..This study examines changes in severity of tics and ADHD during atomoxetine treatment in ADHD patients with Tourette syndrome (TS)...
  79. ncbi request reprint Clinical presentation of attention-deficit/hyperactivity disorder in preschool children: the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    Kelly Posner
    New York State Psychiatric Institute Columbia University, 1041 Riverside Drive, New York, NY 10032, USA
    J Child Adolesc Psychopharmacol 17:547-62. 2007
    ..The diagnosis and evaluation process will also be described...
  80. ncbi request reprint Comorbidity moderates response to methylphenidate in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    Jaswinder K Ghuman
    University of Arizona, 1501 N Campbell Avenue, Tucson, AZ 85724, USA
    J Child Adolesc Psychopharmacol 17:563-80. 2007
    ..The aim of this study was to examine whether demographic or pretreatment clinical and social characteristics influenced the response to methylphenidate (MPH) in the Preschoolers with ADHD Treatment Study (PATS)...
  81. ncbi request reprint Methylphenidate effects on functional outcomes in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    Howard B Abikoff
    New York University Child Study Center, 215 Lexington Avenue, New York, NY 10016, USA
    J Child Adolesc Psychopharmacol 17:581-92. 2007
    ....
  82. ncbi request reprint Effectiveness of methylphenidate in the 10-month continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    Benedetto Vitiello
    Child and Adolescent Treatment and Preventive Intervention Research Branch, National Institute of Mental Health, 6001 Executive Boulevard, Bethesda, MD 20892, USA
    J Child Adolesc Psychopharmacol 17:593-604. 2007
    ..The aim of this study was to examine immediate-release methylphenidate effectiveness during the 10-month open-label continuation phase of the Preschoolers with Attention-Deficit/Hyperactivity Disorder (ADHD) Treatment Study (PATS)...
  83. ncbi request reprint Familiality of factor analysis-derived YBOCS dimensions in OCD-affected sibling pairs from the OCD Collaborative Genetics Study
    Gregor Hasler
    Laboratory of Clinical Science, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland
    Biol Psychiatry 61:617-25. 2007
    ..While factor-analytic studies have found consistent, clinically meaningful OCD symptom dimensions, there have been only limited attempts to evaluate the familiality and potential genetic basis of such dimensions...
  84. ncbi request reprint Parent versus teacher ratings of attention-deficit/hyperactivity disorder symptoms in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    Desiree W Murray
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    J Child Adolesc Psychopharmacol 17:605-20. 2007
    ..To assess parent-teacher concordance on ratings of DSM-IV symptoms of attention-deficit/hyperactivity disorder (ADHD) in a sample of preschool children referred for an ADHD treatment study...
  85. ncbi request reprint Factor structure of parent- and teacher-rated attention-deficit/hyperactivity disorder symptoms in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    Kristina K Hardy
    Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA
    J Child Adolesc Psychopharmacol 17:621-34. 2007
    ....
  86. ncbi request reprint Effects of source of DNA on genotyping success rates and allele percentages in the Preschoolers with Attention-Deficit/Hyperactivity Disorder Treatment Study (PATS)
    James M Swanson
    Child Development Center, University of California Irvine, 19722 MacArthur Boulevard, Irvine, CA 92612, USA
    J Child Adolesc Psychopharmacol 17:635-46. 2007
    ....
  87. ncbi request reprint Positive effects of methylphenidate on inattention and hyperactivity in pervasive developmental disorders: an analysis of secondary measures
    David J Posey
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Biol Psychiatry 61:538-44. 2007
    ....
  88. ncbi request reprint Review of safety assessment methods used in pediatric psychopharmacology
    Laurence L Greenhill
    New York State Psychiatric Institute Columbia University, New York 10032, USA
    J Am Acad Child Adolesc Psychiatry 42:627-33. 2003
    ..Elicitation is an essential and critical step in ascertaining adverse events (AEs). This report reviews elicitation methods used in published clinical trials of psychopharmacological agents in children...
  89. ncbi request reprint The Texas Children's Medication Algorithm Project: revision of the algorithm for pharmacotherapy of attention-deficit/hyperactivity disorder
    Steven R Pliszka
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    J Am Acad Child Adolesc Psychiatry 45:642-57. 2006
    ..Advances in the psychopharmacology of ADHD and results of a feasibility study of algorithm use in community mental health centers caused the algorithm to be modified and updated...
  90. ncbi request reprint Fluoxetine treatment for prevention of relapse of depression in children and adolescents: a double-blind, placebo-controlled study
    Graham J Emslie
    University of Texas Southwestern Medical Center at Dallas, Texas, USA
    J Am Acad Child Adolesc Psychiatry 43:1397-405. 2004
    ....
  91. ncbi request reprint Second-generation antipsychotic medications in children and adolescents
    Jennifer Cheng-Shannon
    Department of Psychiatry, University of Washington School of Medicine, Seattle, WA, USA
    J Child Adolesc Psychopharmacol 14:372-94. 2004
    ..We reviewed available pediatric literature on second-generation antipsychotic medications to assess current evidence of efficacy and safety...
  92. ncbi request reprint Validity of the autism diagnostic interview-revised
    Luc Lecavalier
    Nisonger Center, The Ohio State University, Columbus, USA
    Am J Ment Retard 111:199-215. 2006
    ..They indicated some similarities between constructs, but also that the ADI-R measures autism in a unique fashion...
  93. ncbi request reprint Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study
    Jack F Samuels
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Meyer 4 181, Baltimore, MD 21287 7228, USA
    Behav Res Ther 45:673-86. 2007
    ..The findings suggest that hoarding behavior may help differentiate a distinct clinical subgroup of people with OCD and may aggregate in some OCD families. Indecision may be a risk factor for hoarding in these families...

Research Grants11

  1. OCD Collaborative Genetics Association Study
    James T McCracken; Fiscal Year: 2010
    ..The results of these analyses will guide future molecular strategies to identify genes involved in the pathogenesis of OCD. The clinical and genotype data from the sample will be publicly available for OCD genetics research. ..
  2. Drug Response in Pediatric Psychopharmacology
    James McCracken; Fiscal Year: 2005
    ..The support from the proposed Mid-Career Award would significantly enhance the candidate's research background and enable a redoubled effort in his research and mentoring activities. ..
  3. 3/4-RUPP Autism Network: Guanfacine for the Treatment of Hyperactivity in PDD
    James T McCracken; Fiscal Year: 2010
    ..Methylphenidate or placebo will be added for children who show partial benefit to guanfacine. ..
  4. OCD Collaborative Genetics Association Study
    James McCracken; Fiscal Year: 2009
    ..The results of these analyses will guide future molecular strategies to identify genes involved in the pathogenesis of OCD. The clinical and genotype data from the sample will be publicly available for OCD genetics research. ..
  5. OCD Collaborative Genetics Association Study
    James McCracken; Fiscal Year: 2007
    ..The results of these analyses will guide future molecular strategies to identify genes involved in the pathogenesis of OCD. The clinical and genotype data from the sample will be publicly available for OCD genetics research. ..
  6. Follow up of the PATS sample
    James McCracken; Fiscal Year: 2007
    ..g., sleep disturbance, tics) effects. The Secondary Aim is to collect information on the course of psychopathology and functioning of the PATS children. ..
  7. Training The Science of Child Mental Health Treatment
    James McCracken; Fiscal Year: 2007
    ..The program will benefit from the breadth of active treatment research at UCLA and from the supplemental cross-disciplinary training available from a wide variety of departments, programs, research units, and other training activities. ..