Thomas McCown

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Adeno-Associated Virus (AAV) Vectors in the CNS
    Thomas J McCown
    UNC Gene Therapy Center, University of North Carolina School of Medicine, Chapel Hill, 27599, USA
    Curr Gene Ther 11:181-8. 2011
  2. pmc Adeno-associated virus vector-mediated expression and constitutive secretion of galanin suppresses limbic seizure activity
    Thomas J McCown
    UNC Gene Therapy Center, Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Neurotherapeutics 6:307-11. 2009
  3. ncbi request reprint Adeno-associated virus-mediated expression and constitutive secretion of galanin suppresses limbic seizure activity in vivo
    Thomas J McCown
    Gene Therapy Center and Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA
    Mol Ther 14:63-8. 2006
  4. ncbi request reprint Adeno-associated virus (AAV) vectors in the CNS
    Thomas J McCown
    Gene Therapy Center, University of North Carolina School of Medicine, 7119 Thurston, CB 7352, Chapel Hill, NC 27599, USA
    Curr Gene Ther 5:333-8. 2005
  5. ncbi request reprint The clinical potential of antiepileptic gene therapy
    Thomas J McCown
    University of North Carolina at Chapel Hill, Gene Therapy Center and Department of Psychiatry, Chapel Hill, North Carolina, USA
    Expert Opin Biol Ther 4:1771-6. 2004
  6. doi request reprint The future of epilepsy treatment: focus on adeno-associated virus vector gene therapy
    Thomas J McCown
    UNC Gene Therapy Center, Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Drug News Perspect 23:281-6. 2010
  7. pmc Notable reduction in illegitimate integration mediated by a PPT-deleted, nonintegrating lentiviral vector
    Boris Kantor
    Gene Therapy Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Mol Ther 19:547-56. 2011
  8. ncbi request reprint Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion
    Rebecca P Haberman
    Gene Therapy Center, 7119 Thurston Bowles Building, CB 7352, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Nat Med 9:1076-80. 2003
  9. pmc Therapeutic liabilities of in vivo viral vector tropism: adeno-associated virus vectors, NMDAR1 antisense, and focal seizure sensitivity
    Rebecca Haberman
    UNC Gene Therapy Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Ther 6:495-500. 2002
  10. pmc Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB)
    Steven J Gray
    UNC Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Mol Ther 18:570-8. 2010

Research Grants

  1. GENE THERAPY AND SEIZURES
    Thomas J McCown; Fiscal Year: 2010
  2. GENE THERAPY AND SEIZURES
    Thomas McCown; Fiscal Year: 2009
  3. Directed Evolution of Adeno-Associated Virus Vectors for Seizure Gene Therapy
    Thomas McCown; Fiscal Year: 2007
  4. GENE THERAPY AND SEIZURES
    Thomas McCown; Fiscal Year: 2005
  5. GENE THERAPY AND SEIZURES
    Thomas McCown; Fiscal Year: 2004
  6. GENE THERAPY AND SEIZURES
    Thomas McCown; Fiscal Year: 2003
  7. GENE THERAPY AND SEIZURES
    Thomas McCown; Fiscal Year: 2002
  8. GENE THERAPY AND SEIZURES
    Thomas McCown; Fiscal Year: 2001
  9. GENE THERAPY AND SEIZURES
    Thomas McCown; Fiscal Year: 2000
  10. GENE THERAPY AND SEIZURES
    Thomas McCown; Fiscal Year: 1999

Collaborators

  • Chengwen Li
  • Tal Kafri
  • Aravind Asokan
  • Xiao Xiao
  • Haiyan Fu
  • H E Criswell
  • DONALD EUGENE REDMOND
  • NORMAN SHARPLESS
  • Joseph Muenzer
  • R Jude Samulski
  • Hong Ma
  • Boris Kantor
  • Jarrod S Johnson
  • Matthew Bayer
  • Wuping Li
  • Rebecca P Haberman
  • Adam S Cockrell
  • Steven J Gray
  • Nina DiPrimio
  • Xiaohuai Zhou
  • Vivian W Choi
  • Karin Haack
  • Rebecca Haberman
  • Jude Samulski
  • Sarah C Nicolson
  • Marc S Weinberg
  • Bonita L Blake
  • Zhenghong Fan
  • Richard J Samulski
  • Adam Cockrell
  • Xinghua Zeng
  • Stefan Leichtle
  • Zhijian Wu
  • Mavis Agbandje-McKenna
  • Terry van Dyke
  • Brian Zeithaml
  • Lakshmanan Govindaswamy
  • Kimberly B Petermann
  • Xiangping Li
  • Kailing Fu
  • Richard Jude Samulski
  • Rebecca A Haberman
  • Steffan N Ho
  • David Israeli
  • George Breese
  • Stephen Snowdy
  • Zhen Ming
  • R Samulski

Detail Information

Publications19

  1. ncbi request reprint Adeno-Associated Virus (AAV) Vectors in the CNS
    Thomas J McCown
    UNC Gene Therapy Center, University of North Carolina School of Medicine, Chapel Hill, 27599, USA
    Curr Gene Ther 11:181-8. 2011
    ..In many cases the proposed therapies have progressed to phase I/II clinical trials. Each individual application, however, presents a unique set of challenges that must be solved in order to attain clinically effective gene therapies...
  2. pmc Adeno-associated virus vector-mediated expression and constitutive secretion of galanin suppresses limbic seizure activity
    Thomas J McCown
    UNC Gene Therapy Center, Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Neurotherapeutics 6:307-11. 2009
    ..Thus, these studies clearly demonstrate the anti-seizure effectiveness of AAV vector-mediated expression and constitutive secretion of galanin...
  3. ncbi request reprint Adeno-associated virus-mediated expression and constitutive secretion of galanin suppresses limbic seizure activity in vivo
    Thomas J McCown
    Gene Therapy Center and Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA
    Mol Ther 14:63-8. 2006
    ..Thus, AAV-mediated galanin expression and secretion significantly suppress limbic seizure activity in vivo...
  4. ncbi request reprint Adeno-associated virus (AAV) vectors in the CNS
    Thomas J McCown
    Gene Therapy Center, University of North Carolina School of Medicine, 7119 Thurston, CB 7352, Chapel Hill, NC 27599, USA
    Curr Gene Ther 5:333-8. 2005
    ..Each individual application, however, presents a unique set of challenges that must be solved in order to attain clinically effective gene therapies...
  5. ncbi request reprint The clinical potential of antiepileptic gene therapy
    Thomas J McCown
    University of North Carolina at Chapel Hill, Gene Therapy Center and Department of Psychiatry, Chapel Hill, North Carolina, USA
    Expert Opin Biol Ther 4:1771-6. 2004
    ....
  6. doi request reprint The future of epilepsy treatment: focus on adeno-associated virus vector gene therapy
    Thomas J McCown
    UNC Gene Therapy Center, Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Drug News Perspect 23:281-6. 2010
    ..Thus, in the more distant future, AAV therapeutics for focal epilepsies may be delivered without any neurosurgical interventions...
  7. pmc Notable reduction in illegitimate integration mediated by a PPT-deleted, nonintegrating lentiviral vector
    Boris Kantor
    Gene Therapy Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Mol Ther 19:547-56. 2011
    ....
  8. ncbi request reprint Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion
    Rebecca P Haberman
    Gene Therapy Center, 7119 Thurston Bowles Building, CB 7352, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Nat Med 9:1076-80. 2003
    ..Thus, neuroactive peptide expression and local secretion provides a new gene therapy platform for the treatment of neurological disorders...
  9. pmc Therapeutic liabilities of in vivo viral vector tropism: adeno-associated virus vectors, NMDAR1 antisense, and focal seizure sensitivity
    Rebecca Haberman
    UNC Gene Therapy Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Mol Ther 6:495-500. 2002
    ..Although AAV vector-derived NMDAR1 antisense can influence NMDA receptor function both in vitro and in vivo, promoter-related tropic differences dramatically alter the physiological outcome of this receptor-based gene therapy...
  10. pmc Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB)
    Steven J Gray
    UNC Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Mol Ther 18:570-8. 2010
    ..Thus, novel AAV vectors have been created that can selectively cross the seizure-compromised BBB and transduce cells...
  11. pmc A large U3 deletion causes increased in vivo expression from a nonintegrating lentiviral vector
    Matthew Bayer
    Gene Therapy Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
    Mol Ther 16:1968-76. 2008
    ..Finally, and for the first time, episomal expression in the mouse liver was potent and sustained...
  12. doi request reprint Adeno-associated virus of a single-polarity DNA genome is capable of transduction in vivo
    Xiaohuai Zhou
    Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Mol Ther 16:494-9. 2008
    ..The availability of the single-polarity AAV vector would aid further studies on the mechanism of AAV transduction as well as the application of AAV vector for gene replacement therapy...
  13. ncbi request reprint Regulation of gene expression in adeno-associated virus vectors in the brain
    Rebecca P Haberman
    Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Methods 28:219-26. 2002
    ..Thus regulated vector systems must be carefully optimized for each application...
  14. doi request reprint Production of recombinant adeno-associated viral vectors and use for in vitro and in vivo administration
    Vivian W Choi
    University of North Carolina, Chapel Hill, North Carolina, USA
    Curr Protoc Neurosci . 2006
    ..Two detailed methods are provided for viral vector injection into rat brain and for histological detection of transgene expression, including lacZ and GFP...
  15. ncbi request reprint Neurological correction of lysosomal storage in a mucopolysaccharidosis IIIB mouse model by adeno-associated virus-mediated gene delivery
    Haiyan Fu
    Division of Genetics and Metabolism, Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Mol Ther 5:42-9. 2002
    ..5 mm) in a 6-month duration of experiments. These results provide a basis for the development of a treatment for neurological disease in MPS IIIB patients using AAV vectors...
  16. pmc Engineering and selection of shuffled AAV genomes: a new strategy for producing targeted biological nanoparticles
    Wuping Li
    Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7352, USA
    Mol Ther 16:1252-60. 2008
    ..Application of this technology to alternative cell/tissue types using AAV or other viral capsid sequences is likely to yield a new class of biological nanoparticles as vectors for human gene transfer...
  17. ncbi request reprint Transactivator and structurally optimized inducible lentiviral vectors
    Karin Haack
    Gene Therapy Center, University of North Carolina at Chapel Hill, 7119 Thurston Bowles, CB 7352, Chapel Hill, NC 27599 7352, USA
    Mol Ther 10:585-96. 2004
    ....
  18. pmc Mutagenesis of adeno-associated virus type 2 capsid protein VP1 uncovers new roles for basic amino acids in trafficking and cell-specific transduction
    Jarrod S Johnson
    Department of Pharmacology, Gene Therapy Center, University of North Carolina, Chapel Hill, North Carolina 27599 7352, USA
    J Virol 84:8888-902. 2010
    ..e., subnuclear mobilization or uncoating) limit successful AAV infection...
  19. ncbi request reprint A trans-lentiviral packaging cell line for high-titer conditional self-inactivating HIV-1 vectors
    Adam S Cockrell
    Gene Therapy Center, University of North Carolina at Chapel Hill, 7119 Thurston Bowles, CB 7352, 27599 7352, USA
    Mol Ther 14:276-84. 2006
    ..Furthermore, cSIN vectors generated from SODk3 packaging cells imparted efficient transduction of primary human fibroblasts, an indication of the future applicability of the SODk3 packaging cell line...

Research Grants16

  1. GENE THERAPY AND SEIZURES
    Thomas J McCown; Fiscal Year: 2010
    ..The present proposed studies will define the most efficacious adeno-associated virus vector which will provide a viable gene therapy treatment for intractable epilepsy. ..
  2. GENE THERAPY AND SEIZURES
    Thomas McCown; Fiscal Year: 2009
    ..The present proposed studies will define the most efficacious adeno-associated virus vector which will provide a viable gene therapy treatment for intractable epilepsy. ..
  3. Directed Evolution of Adeno-Associated Virus Vectors for Seizure Gene Therapy
    Thomas McCown; Fiscal Year: 2007
    ..If successful, this novel approach could greatly advance the application of gene therapy to the treatment of neurological disorders. ..
  4. GENE THERAPY AND SEIZURES
    Thomas McCown; Fiscal Year: 2005
    ..The findings from these studies could lead to a novel gene therapeutic approach to the treatment of epilepsy. ..
  5. GENE THERAPY AND SEIZURES
    Thomas McCown; Fiscal Year: 2004
    ..The findings from these studies could lead to a novel gene therapeutic approach to the treatment of epilepsy. ..
  6. GENE THERAPY AND SEIZURES
    Thomas McCown; Fiscal Year: 2003
    ..The findings from these studies could lead to a novel gene therapeutic approach to the treatment of epilepsy. ..
  7. GENE THERAPY AND SEIZURES
    Thomas McCown; Fiscal Year: 2002
    ..The findings from these studies could lead to a novel gene therapeutic approach to the treatment of epilepsy. ..
  8. GENE THERAPY AND SEIZURES
    Thomas McCown; Fiscal Year: 2001
    ..Moreover, since we are targeting receptors that modulate seizure sensitivity, the findings may have direct application to the treatment of focal seizure disorders. ..
  9. GENE THERAPY AND SEIZURES
    Thomas McCown; Fiscal Year: 2000
    ..Moreover, since we are targeting receptors that modulate seizure sensitivity, the findings may have direct application to the treatment of focal seizure disorders. ..
  10. GENE THERAPY AND SEIZURES
    Thomas McCown; Fiscal Year: 1999
    ..Moreover, since we are targeting receptors that modulate seizure sensitivity, the findings may have direct application to the treatment of focal seizure disorders. ..
  11. GENE THERAPY AND SEIZURES
    Thomas McCown; Fiscal Year: 1999
    ..Moreover, since we are targeting receptors that modulate seizure sensitivity, the findings may have direct application to the treatment of focal seizure disorders. ..
  12. GENE THERAPY AND SEIZURES
    Thomas J McCown; Fiscal Year: 2011
    ..The present proposed studies will define the most efficacious adeno-associated virus vector which will provide a viable gene therapy treatment for intractable epilepsy. ..