Research Topics
| Thomas McCownSummaryAffiliation: University of North Carolina Country: USA Publications
Research Grants
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Detail Information
Publications
Adeno-Associated Virus (AAV) Vectors in the CNSThomas J McCown
UNC Gene Therapy Center, University of North Carolina School of Medicine, Chapel Hill, 27599, USA
Curr Gene Ther 11:181-8. 2011..In many cases the proposed therapies have progressed to phase I/II clinical trials. Each individual application, however, presents a unique set of challenges that must be solved in order to attain clinically effective gene therapies...
Adeno-associated virus vector-mediated expression and constitutive secretion of galanin suppresses limbic seizure activityThomas J McCown
UNC Gene Therapy Center, Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Neurotherapeutics 6:307-11. 2009..Thus, these studies clearly demonstrate the anti-seizure effectiveness of AAV vector-mediated expression and constitutive secretion of galanin...- Adeno-associated virus-mediated expression and constitutive secretion of galanin suppresses limbic seizure activity in vivoThomas J McCown
Gene Therapy Center and Department of Psychiatry, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA
Mol Ther 14:63-8. 2006..Thus, AAV-mediated galanin expression and secretion significantly suppress limbic seizure activity in vivo... - Adeno-associated virus (AAV) vectors in the CNSThomas J McCown
Gene Therapy Center, University of North Carolina School of Medicine, 7119 Thurston, CB 7352, Chapel Hill, NC 27599, USA
Curr Gene Ther 5:333-8. 2005..Each individual application, however, presents a unique set of challenges that must be solved in order to attain clinically effective gene therapies... - The clinical potential of antiepileptic gene therapyThomas J McCown
University of North Carolina at Chapel Hill, Gene Therapy Center and Department of Psychiatry, Chapel Hill, North Carolina, USA
Expert Opin Biol Ther 4:1771-6. 2004.... 
The future of epilepsy treatment: focus on adeno-associated virus vector gene therapyThomas J McCown
UNC Gene Therapy Center, Department of Psychiatry, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Drug News Perspect 23:281-6. 2010..Thus, in the more distant future, AAV therapeutics for focal epilepsies may be delivered without any neurosurgical interventions...- Notable reduction in illegitimate integration mediated by a PPT-deleted, nonintegrating lentiviral vectorBoris Kantor
Gene Therapy Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
Mol Ther 19:547-56. 2011.... - Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretionRebecca P Haberman
Gene Therapy Center, 7119 Thurston-Bowles Building, CB 7352, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
Nat Med 9:1076-80. 2003..Thus, neuroactive peptide expression and local secretion provides a new gene therapy platform for the treatment of neurological disorders... - Therapeutic liabilities of in vivo viral vector tropism: adeno-associated virus vectors, NMDAR1 antisense, and focal seizure sensitivityRebecca Haberman
UNC Gene Therapy Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Mol Ther 6:495-500. 2002..Although AAV vector-derived NMDAR1 antisense can influence NMDA receptor function both in vitro and in vivo, promoter-related tropic differences dramatically alter the physiological outcome of this receptor-based gene therapy... - Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB)Steven J Gray
UNC Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Mol Ther 18:570-8. 2010..Thus, novel AAV vectors have been created that can selectively cross the seizure-compromised BBB and transduce cells... - A large U3 deletion causes increased in vivo expression from a nonintegrating lentiviral vectorMatthew Bayer
Gene Therapy Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599, USA
Mol Ther 16:1968-76. 2008..Finally, and for the first time, episomal expression in the mouse liver was potent and sustained... - Adeno-associated virus of a single-polarity DNA genome is capable of transduction in vivoXiaohuai Zhou
Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
Mol Ther 16:494-9. 2008..The availability of the single-polarity AAV vector would aid further studies on the mechanism of AAV transduction as well as the application of AAV vector for gene replacement therapy... - Regulation of gene expression in adeno-associated virus vectors in the brainRebecca P Haberman
Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Methods 28:219-26. 2002..Thus regulated vector systems must be carefully optimized for each application... - Production of recombinant adeno-associated viral vectors and use for in vitro and in vivo administrationVivian W Choi
University of North Carolina, Chapel Hill, North Carolina, USA
Curr Protoc Neurosci . 2006..Two detailed methods are provided for viral vector injection into rat brain and for histological detection of transgene expression, including lacZ and GFP... - Neurological correction of lysosomal storage in a mucopolysaccharidosis IIIB mouse model by adeno-associated virus-mediated gene deliveryHaiyan Fu
Division of Genetics and Metabolism, Department of Pediatrics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Mol Ther 5:42-9. 2002..5 mm) in a 6-month duration of experiments. These results provide a basis for the development of a treatment for neurological disease in MPS IIIB patients using AAV vectors... - Engineering and selection of shuffled AAV genomes: a new strategy for producing targeted biological nanoparticlesWuping Li
Gene Therapy Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7352, USA
Mol Ther 16:1252-60. 2008..Application of this technology to alternative cell/tissue types using AAV or other viral capsid sequences is likely to yield a new class of biological nanoparticles as vectors for human gene transfer... - Transactivator and structurally optimized inducible lentiviral vectorsKarin Haack
Gene Therapy Center, University of North Carolina at Chapel Hill, 7119 Thurston Bowles, CB 7352, Chapel Hill, NC 27599-7352, USA
Mol Ther 10:585-96. 2004.... - Mutagenesis of adeno-associated virus type 2 capsid protein VP1 uncovers new roles for basic amino acids in trafficking and cell-specific transductionJarrod S Johnson
Department of Pharmacology, Gene Therapy Center, University of North Carolina, Chapel Hill, North Carolina 27599 7352, USA
J Virol 84:8888-902. 2010..e., subnuclear mobilization or uncoating) limit successful AAV infection... - A trans-lentiviral packaging cell line for high-titer conditional self-inactivating HIV-1 vectorsAdam S Cockrell
Gene Therapy Center, University of North Carolina at Chapel Hill, 7119 Thurston Bowles, CB 7352, 27599-7352, USA
Mol Ther 14:276-84. 2006..Furthermore, cSIN vectors generated from SODk3 packaging cells imparted efficient transduction of primary human fibroblasts, an indication of the future applicability of the SODk3 packaging cell line...
Research Grants
- GENE THERAPY AND SEIZURESThomas J McCown; Fiscal Year: 2010..The present proposed studies will define the most efficacious adeno-associated virus vector which will provide a viable gene therapy treatment for intractable epilepsy. ..
- Directed Evolution of Adeno-Associated Virus Vectors for Seizure Gene TherapyThomas McCown; Fiscal Year: 2007..If successful, this novel approach could greatly advance the application of gene therapy to the treatment of neurological disorders. ..
- GENE THERAPY AND SEIZURESThomas McCown; Fiscal Year: 2005..The findings from these studies could lead to a novel gene therapeutic approach to the treatment of epilepsy. ..
- GENE THERAPY AND SEIZURESThomas McCown; Fiscal Year: 2001..Moreover, since we are targeting receptors that modulate seizure sensitivity, the findings may have direct application to the treatment of focal seizure disorders. ..
- GENE THERAPY AND SEIZURESThomas J McCown; Fiscal Year: 2011..The present proposed studies will define the most efficacious adeno-associated virus vector which will provide a viable gene therapy treatment for intractable epilepsy. ..