F McCormick

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Activation of the hedgehog pathway in advanced prostate cancer
    Tao Sheng
    Sealy Centers for Cancer Cell Biology and Environmental Health, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555 1048, USA
    Mol Cancer 3:29. 2004
  2. ncbi request reprint Success and failure on the ras pathway
    Frank McCormick
    UCSF Comprehensive Cancer Center, USA
    Cancer Biol Ther 6:1654-9. 2007
  3. ncbi request reprint Cancer-specific viruses and the development of ONYX-015
    Frank McCormick
    University of California San Francisco, Cancer Research Institute San Francisco, California 94115, USA
    Cancer Biol Ther 2:S157-60. 2003
  4. ncbi request reprint Cancer gene therapy: fringe or cutting edge?
    F McCormick
    University of California San Francisco, Cancer Research Institute, 94115, USA
    Nat Rev Cancer 1:130-41. 2001
  5. doi request reprint Cancer therapy based on oncogene addiction
    Frank McCormick
    UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94158 9001, USA
    J Surg Oncol 103:464-7. 2011
  6. ncbi request reprint Interactions between adenovirus proteins and the p53 pathway: the development of ONYX-015
    F McCormick
    Cancer Research Institute, UCSF Cancer Comprehensive Cancer Center, San Francisco, CA 94115, USA
    Semin Cancer Biol 10:453-9. 2000
  7. ncbi request reprint Small-molecule inhibitors of cell signaling
    F McCormick
    Cancer Research Institute, 2340 Sutter Street, San Francisco, CA 94115, USA
    Curr Opin Biotechnol 11:593-7. 2000
  8. ncbi request reprint Signalling networks that cause cancer
    F McCormick
    UCSF Cancer Center, Cancer Research Institute, 2340 Sutter St, San Francisco, CA 94115, USA
    Trends Cell Biol 9:M53-6. 1999
  9. doi request reprint Mutant onco-proteins as drug targets: successes, failures, and future prospects
    Frank McCormick
    Helen Diller Family Comprehensive Cancer Center, UCSF, 1450 3rd Street, Room 371, Box 0128, San Francisco, CA 94158, USA
    Curr Opin Genet Dev 21:29-33. 2011
  10. ncbi request reprint A mammalian two-hybrid system for adenomatous polyposis coli-mutated colon cancer therapeutics
    K Wakita
    Cancer Research Institute, University of California, San Francisco, School of Medicine, 94143-0128, USA
    Cancer Res 61:854-8. 2001

Research Grants

  1. CANCER CENTER SUPPORT GRANT
    Frank McCormick; Fiscal Year: 2007

Detail Information

Publications90

  1. pmc Activation of the hedgehog pathway in advanced prostate cancer
    Tao Sheng
    Sealy Centers for Cancer Cell Biology and Environmental Health, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555 1048, USA
    Mol Cancer 3:29. 2004
    ..Prostate cancer is the second most prevalent cause of cancer death in American men. Therefore, identification of novel therapeutic targets for prostate cancer has significant clinical implications...
  2. ncbi request reprint Success and failure on the ras pathway
    Frank McCormick
    UCSF Comprehensive Cancer Center, USA
    Cancer Biol Ther 6:1654-9. 2007
  3. ncbi request reprint Cancer-specific viruses and the development of ONYX-015
    Frank McCormick
    University of California San Francisco, Cancer Research Institute San Francisco, California 94115, USA
    Cancer Biol Ther 2:S157-60. 2003
    ..Here, I summarize issues relating to selectivity of this agent and its clinical potential. Based on clinical data and new basic discoveries, several approaches are suggested to improve the efficacy of this agent in the clinic...
  4. ncbi request reprint Cancer gene therapy: fringe or cutting edge?
    F McCormick
    University of California San Francisco, Cancer Research Institute, 94115, USA
    Nat Rev Cancer 1:130-41. 2001
    ..These issues are not trivial, but seem less formidable than the challenge of killing cancers selectively and rationally--a challenge that has been successfully addressed...
  5. doi request reprint Cancer therapy based on oncogene addiction
    Frank McCormick
    UCSF Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California 94158 9001, USA
    J Surg Oncol 103:464-7. 2011
    ..The Ras-MAPK pathway provides examples of these successes and failures, and has revealed unexpected degrees of oncogene addiction and signaling complexity that are likely to be useful lessons for the future of targeted therapy...
  6. ncbi request reprint Interactions between adenovirus proteins and the p53 pathway: the development of ONYX-015
    F McCormick
    Cancer Research Institute, UCSF Cancer Comprehensive Cancer Center, San Francisco, CA 94115, USA
    Semin Cancer Biol 10:453-9. 2000
    ..In normal cells, dl1520 induces p53, and is generally strongly attenuated for replication. ONYX-015 is currently being tested in clinical trials, and is a promising new therapeutic agent in cancer...
  7. ncbi request reprint Small-molecule inhibitors of cell signaling
    F McCormick
    Cancer Research Institute, 2340 Sutter Street, San Francisco, CA 94115, USA
    Curr Opin Biotechnol 11:593-7. 2000
    ..New strategies are being developed to interfere with previously intractable targets, such as protein-protein interactions...
  8. ncbi request reprint Signalling networks that cause cancer
    F McCormick
    UCSF Cancer Center, Cancer Research Institute, 2340 Sutter St, San Francisco, CA 94115, USA
    Trends Cell Biol 9:M53-6. 1999
    ..The interactive nature of each genetic change has important implications for cancer therapy and for the stepwise model of carcinogenesis...
  9. doi request reprint Mutant onco-proteins as drug targets: successes, failures, and future prospects
    Frank McCormick
    Helen Diller Family Comprehensive Cancer Center, UCSF, 1450 3rd Street, Room 371, Box 0128, San Francisco, CA 94158, USA
    Curr Opin Genet Dev 21:29-33. 2011
    ..In both cases, new approaches will be necessary. Development of systemic RNA interference may be a solution to these problems...
  10. ncbi request reprint A mammalian two-hybrid system for adenomatous polyposis coli-mutated colon cancer therapeutics
    K Wakita
    Cancer Research Institute, University of California, San Francisco, School of Medicine, 94143-0128, USA
    Cancer Res 61:854-8. 2001
    ..Replacement of the reporter gene with a suicide gene resulted in selective killing of SW480 cells. This system may be applicable for broader use of gene therapy by targeting diseases that involve protein degradation...
  11. ncbi request reprint Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    O Tetsu
    University of California, San Francisco, School of Medicine, Cancer Research Institute, 94143 0128, USA
    Nature 398:422-6. 1999
    ..Abnormal levels of beta-catenin may therefore contribute to neoplastic transformation by causing accumulation of cyclin D1...
  12. ncbi request reprint Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome
    Pablo Rodriguez-Viciana
    Comprehensive Cancer Center and Cancer Research Institute, University of California, San Francisco, CA 94115, USA
    Science 311:1287-90. 2006
    ..Our findings highlight the involvement of the MAPK pathway in human development and will provide a molecular diagnosis of CFC syndrome...
  13. ncbi request reprint Inhibition of the Raf/MEK/ERK pathway up-regulates expression of the coxsackievirus and adenovirus receptor in cancer cells
    Mario Anders
    Cancer Research Institute, University of California, San Francisco 94143, USA
    Cancer Res 63:2088-95. 2003
    ....
  14. ncbi request reprint Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: implications for therapeutic options
    Thanaset Senawong
    Department of Pathology, School of Medicine, University of California, San Francisco, CA 94143 0128, USA
    Hum Mol Genet 17:419-30. 2008
    ..Thus, regardless of mutations identified in an individual with CFC, MEK inhibition is a potential therapeutic approach for this population...
  15. pmc Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint
    Sang Hyun Lee
    Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, California 94115, USA
    Genes Dev 22:2926-31. 2008
    ..These findings reveal an important role for Tpr in which Mad1-Mad2 proteins are regulated during the cell cycle and mitotic spindle checkpoint signaling...
  16. ncbi request reprint Cloning and characterization of the promoter of human Wnt inhibitory factor-1
    Noemi Reguart
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center University of California, San Francisco, CA 94115, USA
    Biochem Biophys Res Commun 323:229-34. 2004
    ....
  17. ncbi request reprint Cancer targets in the Ras pathway
    P Rodriguez-Viciana
    Cancer Research Institute, University of California San Francisco Comprehensive Cancer Center, 94115, USA
    Cold Spring Harb Symp Quant Biol 70:461-7. 2005
    ..However, therapeutic targets in the Ras pathway have not yet been fully validated as bona fide targets...
  18. ncbi request reprint Selective targeting to the hyperactive beta-catenin/T-cell factor pathway in colon cancer cells
    R H Chen
    Cancer Research Institute, University of California San Francisco, 2340 Sutter Street, San Francisco, CA 94115, USA
    Cancer Res 61:4445-9. 2001
    ..Our data therefore provide a conceptual proof that aberrantly activated Wnt/beta-catenin/Tcf pathways can be used to selectively target colon cancers...
  19. ncbi request reprint Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B
    D Stokoe
    Onyx Pharmaceuticals, 3031 Research Drive, Richmond, CA 94806, USA
    Science 277:567-70. 1997
    ..PtdIns(3,4,5)P3 was determined to have a dual role: Its binding to the pleckstrin homology domain of PKB was required to allow phosphorylation by the upstream kinase and it directly activated the upstream kinase...
  20. pmc Adenoviral proteins mimic nutrient/growth signals to activate the mTOR pathway for viral replication
    Clodagh O'Shea
    Cancer Research Institute, University of California, San Francisco, CA, USA
    EMBO J 24:1211-21. 2005
    ..These data reveal that adenovirus has evolved proteins that activate the mTOR pathway, irrespective of the cellular microenvironment, and which play a requisite role in viral replication...
  21. pmc A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation
    Hiroshi Okabe
    Department of Pathology, School of Medicine, University of California San Francisco, San Francisco, California, United States of America UCSF Comprehensive Cancer Center, School of Medicine, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 1:e128. 2006
    ..Thus, FBXW8 plays an essential role in cancer cell proliferation through proteolysis of cyclin D1. It may present new opportunities to develop therapies targeting destruction of cyclin D1 or its regulator E3 ligase selectively...
  22. ncbi request reprint Phosphorylation-independent stabilization of p27kip1 by the phosphoinositide 3-kinase pathway in glioblastoma cells
    Christian H Brandts
    Cancer Research Institute, University of California, San Francisco, California 94115 0128, USA
    J Biol Chem 280:2012-9. 2005
    ..This is further confirmed by the inducible expression of p27(kip1) phosphorylation site mutants, suggesting that p27(kip1) is destabilized in a phosphorylation-independent manner by the PI 3-kinase pathway at the G(1)/S transition...
  23. ncbi request reprint A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity
    Pablo Rodriguez-Viciana
    Cancer Research Institute and Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California 94143, USA
    Mol Cell 22:217-30. 2006
    ..We propose that the Shoc2-PP1c holoenzyme provides an attractive therapeutic target for inhibition of the MAPK pathway in cancer...
  24. pmc A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells
    Biao He
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Neoplasia 6:7-14. 2004
    ..Our results indicate that both monoclonal anti-Wnt-1 antibody and Wnt-1 siRNA inhibit Wnt-1 signaling and can induce apoptosis in human cancer cells. These findings hold promise as a novel therapeutic strategy for cancer...
  25. pmc Role for PP2A in ARF signaling to p53
    Madeleine G Moule
    UCSF Cancer Research Institute, 2340 Sutter Street, San Francisco, CA 94143 0128, USA
    Proc Natl Acad Sci U S A 101:14063-6. 2004
    ..This inhibition requires the small T-antigen PP2A-interacting domain. Our results reveal a previously unrecognized role of PP2A in the modulation of the ARF-p53 tumor suppressor pathway...
  26. ncbi request reprint High frequency of coexistent mutations of PIK3CA and PTEN genes in endometrial carcinoma
    Katsutoshi Oda
    Cancer Research Institute, University of California San Francisco, San Francisco, California 94115, USA
    Cancer Res 65:10669-73. 2005
    ..Our data suggest that the PI3K pathway is extensively activated in endometrial carcinomas, and that combination of PIK3CA/PTEN alterations might play an important role in development of these tumors...
  27. ncbi request reprint Adenovirus overrides cellular checkpoints for protein translation
    Clodagh C O'Shea
    UCSF Cancer Center, San Francisco, California 94115, USA
    Cell Cycle 4:883-8. 2005
    ..We discuss insights from this study, together with the similarities that may exist between viruses and tumor cells with respect to the mechanistic and functional requirements for mTOR activation in driving their aberrant DNA replication...
  28. ncbi request reprint Heat shock phenocopies E1B-55K late functions and selectively sensitizes refractory tumor cells to ONYX-015 oncolytic viral therapy
    Clodagh C O'Shea
    Cancer Research Institute, University of California, San Francisco, CA 94115, USA
    Cancer Cell 8:61-74. 2005
    ..Moreover, these data suggest that the concomitant induction of a heat shock response could significantly improve ONYX-015 cancer therapy...
  29. ncbi request reprint Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways
    Vivianne W Ding
    UCSF Comprehensive Cancer Center, Cancer Research Institute, 2340 Sutter Street, San Francisco, CA 94115, USA
    J Mol Med (Berl) 85:1281-9. 2007
    ..The MAP kinase pathway and E1B55k may also be involved in this dishevelled-p53 connection. Our data provide evidence that there is a novel signaling pathway from Dishevelled to p53...
  30. ncbi request reprint Chromosome aberrations in solid tumors
    Donna G Albertson
    Cancer Research Institute, University of California San Francisco, San Francisco, California 94143 0808, USA
    Nat Genet 34:369-76. 2003
    ....
  31. doi request reprint Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back
    Katherine A Rauen
    University of California San Francisco, San Francisco, California, USA
    Am J Med Genet A 152:4-24. 2010
    ....
  32. ncbi request reprint Expression of the coxsackie adenovirus receptor in normal prostate and in primary and metastatic prostate carcinoma: potential relevance to gene therapy
    Katherine A Rauen
    Department of Pediatrics, University of California, San Francisco, California 94115, USA
    Cancer Res 62:3812-8. 2002
    ..Adenovirus therapy may, therefore, provide an alternate modality in the treatment of prostate cancer and may be especially efficacious in the treatment of metastatic disease...
  33. doi request reprint Costello and cardio-facio-cutaneous syndromes: Moving toward clinical trials in RASopathies
    Katherine A Rauen
    Division of Medical Genetics at the University of California at San Francisco, USA
    Am J Med Genet C Semin Med Genet 157:136-46. 2011
    ..CS and CFC, like other syndromes in their class, have a progressive phenotype and may be amenable to inhibition or normalization of signaling...
  34. ncbi request reprint Induction of apoptosis in mesothelioma cells by antisurvivin oligonucleotides
    Chunyao Xia
    Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, California 94115, USA
    Mol Cancer Ther 1:687-94. 2002
    ..Down-regulation of survivin by a targeted antisense oligonucleotide appears to be an effective gene therapy approach to the treatment of mesothelioma...
  35. ncbi request reprint Phosphorylation of p16INK4A correlates with Cdk4 association
    Jay Gump
    Cancer Research Institute, University of California, San Francisco, California 94143 0128, USA
    J Biol Chem 278:6619-22. 2003
    ..All mapped phosphorylation sites lie outside of the conserved kinase-binding domain of p16 but in regions of the protein affected by mutations in familial and sporadic cancer. Our results suggest a novel regulation of p16 activity...
  36. doi request reprint Molecular aspects, clinical aspects and possible treatment modalities for Costello syndrome: Proceedings from the 1st International Costello Syndrome Research Symposium 2007
    Katherine A Rauen
    Department of Pediatrics, Division of Medical Genetics, University of California, San Francisco, California, USA
    Am J Med Genet A 146:1205-17. 2008
  37. ncbi request reprint Proliferation of cancer cells despite CDK2 inhibition
    Osamu Tetsu
    Cancer Research Institute and Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    Cancer Cell 3:233-45. 2003
    ..Here we report of sustained cell proliferation in the absence of CDK2, and we suggest that CDK2 is not a suitable target for cancer therapy...
  38. ncbi request reprint Late viral RNA export, rather than p53 inactivation, determines ONYX-015 tumor selectivity
    Clodagh C O'Shea
    UCSF Comprehensive Cancer Center, San Francisco, CA 94115, USA
    Cancer Cell 6:611-23. 2004
    ..These data reveal that tumor cells have altered mechanisms for RNA export and resolve the controversial role of p53 in governing ONYX-015 oncolytic selectivity...
  39. ncbi request reprint Cancer therapy based on p53
    F McCormick
    Cancer Research Institute, University of California, San Francisco 94115, USA
    Cancer J Sci Am 5:139-44. 1999
  40. ncbi request reprint Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells
    Biao He
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California San Francisco, 1600 Divisadero Street, San Francisco, CA 94115, USA
    Cancer Res 65:743-8. 2005
    ..Our data also suggest that beta-catenin-independent noncanonical pathway(s) may be involved in the apoptotic inhibition caused by activation of Wnt signaling...
  41. pmc Integrin alphavbeta5 is a primary receptor for adenovirus in CAR-negative cells
    Cynthia Lyle
    UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94158, USA
    Virol J 7:148. 2010
    ..However, a number of studies reporting data which conflicts with this simple model have been published. These observations have led us to question the proposed two-step model for adenovirus infection...
  42. doi request reprint PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation
    Katsutoshi Oda
    Cancer Research Institute, Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, California, USA
    Cancer Res 68:8127-36. 2008
    ..Our data therefore suggest that in tumors with co-occurring mutations in multiple components of the PI3K pathway, selective inhibition of the alpha isoform of p110 is an attractive therapeutic strategy, especially for late-stage tumors...
  43. pmc EGFR signals to mTOR through PKC and independently of Akt in glioma
    Qi Wen Fan
    Department of Neurology, University of California, 533 Parnassus Avenue, San Francisco, CA 94143, USA
    Sci Signal 2:ra4. 2009
    ..These findings underline the importance of signaling between EGFR and mTOR in glioma, identify PKCalpha as essential to this network, and question the necessity of Akt as a critical intermediate coupling EGFR and mTOR in glioma...
  44. pmc p97/DAP5 is a ribosome-associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins
    Sang Hyun Lee
    Cancer Research Institute and Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    EMBO J 25:4008-19. 2006
    ..Taken together, our results demonstrate that p97 is functionally different from the closely related C-terminal two-thirds of eIF4GI and it can positively promote protein synthesis and cell proliferation...
  45. pmc Critical role for arginine methylation in adenovirus-infected cells
    Demetris C Iacovides
    UCSF Comprehensive Cancer Center, 2340 Sutter St, San Francisco, CA 94115, USA
    J Virol 81:13209-17. 2007
    ..These data suggest that arginine methylation of 100K is necessary for its localization to the nucleus and is a critical cellular function necessary for productive adenovirus infection...
  46. ncbi request reprint Downregulation of Skp2 and p27/Kip1 synergistically induces apoptosis in T98G glioblastoma cells
    Sang Hyun Lee
    Cancer Research Institute and Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    J Mol Med (Berl) 83:296-307. 2005
    ..We suggest that Skp2 in tumor cells suppresses apoptosis through Bcl-2 expression, potentially through regulation of cyclin E-CDK2 activity...
  47. pmc Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate
    Pablo Rodriguez-Viciana
    Cancer Research Institute and Comprehensive Cancer Center, University of California, San Francisco, 2340 Sutter St, San Francisco, CA 94143, USA
    Mol Cell Biol 24:4943-54. 2004
    ..It will also likely have critical implications in the treatment of human diseases such as cancer...
  48. ncbi request reprint MDMX inhibits the p300/CBP-mediated acetylation of p53
    Peter Sabbatini
    Research Institute, University of California, School of Medicine, San Francisco, California 94080, USA
    DNA Cell Biol 21:519-25. 2002
    ..These results may have important biologic implications with respect to the MDMX-mediated regulation of p53 activity during development...
  49. doi request reprint E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines
    M Kitagawa
    Helen Diller Family Comprehensive Cancer Center and Cancer Research Institute, University of California, San Francisco, CA 94115, USA
    Oncogene 27:5303-14. 2008
    ..Furthermore, our results suggest that tumor cells, including Rb mutated cells, which harbor wild-type p53 and high E2F transcriptional activity, could be a good target for Mdm2 antagonist therapy...
  50. ncbi request reprint Method for screening ecdysone-inducible stable cell lines
    K Wakita
    University of California, San Francisco, San Francisco, CA, USA
    Biotechniques 31:414-8. 2001
    ..The gene induction was rapid and persistent. Our results demonstrated the advantage of establishing cell lines that continuously express high levels of ecdysone receptor proteins...
  51. ncbi request reprint Phosphoinositide 3-OH kinase (PI3K) and PKB/Akt delay the onset of p53-mediated, transcriptionally dependent apoptosis
    P Sabbatini
    Cancer Research Institute, University of California, School of Medicine, San Francisco, California 94143 0128, USA
    J Biol Chem 274:24263-9. 1999
    ..Our results provide the first direct and unambiguous link between p53-mediated apoptosis and the PI3K-PKB/Akt signaling pathway...
  52. pmc A role of PDGFRalpha in basal cell carcinoma proliferation
    J Xie
    Cancer Research Institute, and Department of Dermatology, University of California, San Francisco, CA 94115, USA
    Proc Natl Acad Sci U S A 98:9255-9. 2001
    ..Therefore, we conclude that increased expression of PDGFRalpha may be an important mechanism by which mutations in the hedgehog pathway cause BCCs...
  53. ncbi request reprint Transcriptional activation of TRADD mediates p53-independent radiation-induced apoptosis of glioma cells
    G L Yount
    Department of Radiation Oncology, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, California, CA 94143, USA
    Oncogene 20:2826-35. 2001
    ..These findings generate interest in utilizing TRADD in gene therapy for GM tumors, particularly in light of its dual function of directly inducing rapid apoptosis and sensitizing GM cells to standard anti-neoplastic therapy...
  54. pmc Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition
    Olga K Mirzoeva
    Department of Medicine, Division of Gastroenterology, University of California, San Francisco, California 94115, USA
    Cancer Res 69:565-72. 2009
    ....
  55. pmc Enhancing tumor-specific uptake of the anticancer drug cisplatin with a copper chelator
    Seiko Ishida
    Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA
    Cancer Cell 17:574-83. 2010
    ..Our results identify the copper transporter as a therapeutic target, which can be manipulated with copper chelating drugs to selectively enhance the benefits of platinum-containing chemotherapeutic agents...
  56. pmc Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: implications for therapy
    Anne L Estep
    Comprehensive Cancer Center and Cancer Research Institute, University of California at San Francisco, San Francisco, California, United States of America
    PLoS ONE 2:e1279. 2007
    ..An understanding of the genetic basis of ovarian cancer has implications both for early detection and for therapeutic intervention in this population of patients...
  57. ncbi request reprint Wnt pathway activation in mesothelioma: evidence of Dishevelled overexpression and transcriptional activity of beta-catenin
    Kazutsugu Uematsu
    Thoracic Oncology Laboratory, Department of Medicine, University of California San Francisco Cancer Center, San Francisco, CA 94115, USA
    Cancer Res 63:4547-51. 2003
    ..These results demonstrate Dvl overexpression in human cancer and, specifically, that Wnt signaling plays a role in mesothelioma pathogenesis. These data offer possible new avenues for therapeutic intervention...
  58. pmc The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans
    Vernon T Phan
    UCSF Helen Diller Family, Comprehensive Cancer Center, 2340 Sutter Street, San Francisco, CA 94115, USA
    Mol Cell Biol 30:2264-79. 2010
    ..These findings provide evidence for conserved ubiquitination pathways regulating the RasGAP proteins Ira2 (in yeast) and neurofibromin (in humans)...
  59. ncbi request reprint Future directions: oncolytic viruses
    Liang You
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Clin Lung Cancer 5:226-30. 2004
    ..Much evidence suggests that oncolytic viral therapy works in synergy with standard cancer therapies. In this review, we will focus on the oncolytic viruses that may be beneficial to patients with lung cancer in the near future...
  60. doi request reprint Skp2 suppresses p53-dependent apoptosis by inhibiting p300
    Mayumi Kitagawa
    Cancer Research Institute and Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94115, USA
    Mol Cell 29:217-31. 2008
    ..Taken together, our results indicate that Skp2 controls p300-p53 signaling pathways in cancer cells, making Skp2 a potential molecular target for cancer therapy...
  61. ncbi request reprint Inhibition of Wnt-1 signaling induces apoptosis in beta-catenin-deficient mesothelioma cells
    Liang You
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, California 94115, USA
    Cancer Res 64:3474-8. 2004
    ..Our data suggest that beta-catenin-independent noncanonical pathway(s), i.e., Wnt/JNK pathway, may play a role in the apoptotic inhibition caused by Wnt-1 signaling...
  62. ncbi request reprint Future prospects for oncolytic therapy
    Frank McCormick
    University of California San Francisco, Cancer Research Institute, CA 94115, USA
    Oncogene 24:7817-9. 2005
    ..When these barriers are overcome, oncolytic viruses could enter the mainstream of clinical oncology...
  63. ncbi request reprint Inhibition of Wnt-2-mediated signaling induces programmed cell death in non-small-cell lung cancer cells
    Liang You
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Oncogene 23:6170-4. 2004
    ....
  64. ncbi request reprint Effects of Onyx-015 among metastatic colorectal cancer patients that have failed prior treatment with 5-FU/leucovorin
    Tony R Reid
    Palo Alto Veteran s Administration Hospital and Stanford University, San Francisco, California, USA
    Cancer Gene Ther 12:673-81. 2005
    ..Onyx-015 may benefit patients with refractory colorectal cancer and additional studies that include PET scans to assess clinical response are warranted...
  65. ncbi request reprint A conditional feedback loop regulates Ras activity through EphA2
    Madhu Macrae
    Cancer Research Institute and Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California 94143, USA
    Cancer Cell 8:111-8. 2005
    ..Our results suggest that an escape from the negative effects of this interaction may be important in the development of cancer...
  66. ncbi request reprint An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth
    Liang You
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California San Francisco, 1600 Divisadero Street, San Francisco, CA 94143 1674, USA
    Cancer Res 64:5385-9. 2004
    ..In an in vivo study, this monoclonal anti-Wnt-2 antibody suppresses tumor growth in a xenograft model. These findings suggest that the anti-Wnt-2 monoclonal antibody may be useful for the treatment of patients with malignant melanoma...
  67. pmc SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer
    Biao He
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, CA 94115, USA
    Proc Natl Acad Sci U S A 100:14133-8. 2003
    ..The data also suggest that SOCS-3 therapy may be useful in the treatment of cancer...
  68. ncbi request reprint RalGDS comes of age
    Pablo Rodriguez-Viciana
    University of California, San Francisco, Cancer Research Institute, 2340 Sutter Street, San Francisco, California, 94115, USA
    Cancer Cell 7:205-6. 2005
    ..Mice lacking RalGDS are defective in tumor formation, possibly because of increased apoptosis in Ras-driven tumors. The hunt for a clear role for RalGDS activation in human cancer is on...
  69. ncbi request reprint Wnt-1 signal as a potential cancer therapeutic target
    Liang You
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California, San Francisco, California 94115, USA
    Drug News Perspect 19:27-31. 2006
    ..This review summarizes the recent significant findings and the potentials of Wnt-1 signal as a new therapeutic target for cancer...
  70. ncbi request reprint Ras ubiquitination: coupling spatial sorting and signal transmission
    Pablo Rodriguez-Viciana
    University of California, San Francisco, Comprehensive Cancer Center, 2340 Sutter Street, San Francisco, California 94115, USA
    Cancer Cell 9:243-4. 2006
    ....
  71. ncbi request reprint Characterization of interactions between ras family GTPases and their effectors
    Pablo Rodriguez-Viciana
    Cancer Research Institute and Comprehensive Cancer Center, University of California, San Francisco, California, USA
    Methods Enzymol 407:187-94. 2006
    ..Determining which of these many candidates are "true" effectors and characterizing their specificity is a critical step to understanding the specific signaling properties and biological functions of the various RFGs...
  72. ncbi request reprint Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression
    Kazutsugu Uematsu
    Thoracic Oncology Laboratory, UCSF Cancer Center, University of California at San Francisco, San Francisco, CA 94115, USA
    Oncogene 22:7218-21. 2003
    ..Taken together, these data support the novel hypothesis that Dvl overexpression is critical to Wnt signaling activation and cell growth in NSCLC...
  73. ncbi request reprint Inhibition of Wnt16 in human acute lymphoblastoid leukemia cells containing the t(1;19) translocation induces apoptosis
    Julien Mazieres
    UCSF Comprehensive Cancer Center, San Francisco, CA 94115, USA
    Oncogene 24:5396-400. 2005
    ..We thus propose that Wnt16 plays an important role in leukemogenesis, raising its therapeutic interest...
  74. ncbi request reprint Cloning and characterization of a functional promoter of the human SOCS-3 gene
    Biao He
    Department of Surgery, Thoracic Oncology Laboratory, Comprehensive Cancer Center, University of California, 1600 Divisadero St, C322C, Box 1674, San Francisco, CA 94115, USA
    Biochem Biophys Res Commun 301:386-91. 2003
    ..Cloning of the human SOCS-3 promoter should help uncover mechanisms of regulation of the JAK-STAT pathway in human cancer...
  75. ncbi request reprint Genomic alterations in human mesothelioma including high resolution mapping of common regions of DNA loss in chromosome arm 6q
    Ronald H Jensen
    Department of Laboratory Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Anticancer Res 23:2281-9. 2003
    ..Molecular genetic analysis of 14 freshly resected human mesotheliomas was used to identify regions in the tumor genomes that display DNA copy number alterations, especially the regions that may harbor tumor suppressor genes...
  76. pmc Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation
    Luika A Timmerman
    University of California Comprehensive Cancer Center, San Francisco, California 94115, USA
    Genes Dev 18:99-115. 2004
    ..Notch is expressed in embryonic regions where EMT occurs, suggesting an intimate and fundamental role for Notch, which may be reactivated during tumor metastasis...
  77. doi request reprint Ras signaling and therapies
    Amy Young
    UCSF Helen Diller Family Comprehensive Cancer Center and Cancer Research Institute, San Francisco, California 94158, USA
    Adv Cancer Res 102:1-17. 2009
    ..Here we will discuss the complexities of Ras signaling and their effects on targeting the Ras pathway in the future...
  78. ncbi request reprint Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer
    Julien Mazieres
    Thoracic Oncology Laboratory, Department of Surgery, Comprehensive Cancer Center, University of California San Francisco, 1600 Divisadero Street, San Francisco, CA 94115, USA
    Cancer Res 64:4717-20. 2004
    ..Our results suggest that methylation silencing of WIF-1 is a common and likely important mechanism of aberrant activation of the Wnt signaling pathway in lung cancer pathogenesis, raising its therapeutic interest...
  79. ncbi request reprint Selectively replicating adenoviruses targeting deregulated E2F activity are potent, systemic antitumor agents
    Leisa Johnson
    Onyx Pharmaceuticals, Richmond, California 94806, USA
    Cancer Cell 1:325-37. 2002
    ....
  80. ncbi request reprint Replication-selective viruses for cancer therapy
    Carola Biederer
    SWITCH Biotech AG, Fraunhofer Strasse 10, 82152 Martinsried, Germany
    J Mol Med (Berl) 80:163-75. 2002
    ..We focus our discussion on a replication-selective adenovirus called ONYX-015 that has recently demonstrated encouraging results in clinical trials..
  81. ncbi request reprint Cancer: survival pathways meet their end
    Frank McCormick
    Nature 428:267-9. 2004
  82. doi request reprint Combinatorial patterns of somatic gene mutations in cancer
    Chen Hsiang Yeang
    Simons Center for Systems Biology, Institute for Advanced Study, Princeton, New Jersey 08540, USA
    FASEB J 22:2605-22. 2008
    ..These combinatorial mutational patterns provide guiding information for the ongoing cancer genome projects...
  83. ncbi request reprint A comparison analysis of anti-tumor efficacy of adenoviral gene replacement therapy (p14ARF and p16INK4A) in human mesothelioma cells
    Cheng Ta Yang
    Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan
    Anticancer Res 23:33-8. 2003
    ..Tumor suppressor genes encode critical cell cycle regulatory proteins that are frequently mutated or deleted in cancer and, therefore, are important candidates for cancer treatment based on gene replacement strategies...
  84. ncbi request reprint Examination of the therapeutic potential of Delta-24-RGD in brain tumor stem cells: role of autophagic cell death
    Hong Jiang
    Brain Tumor Center, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Natl Cancer Inst 99:1410-4. 2007
    ..Our results show for the first time that brain tumor stem cells are susceptible to adenovirus-mediated cell death via autophagy in vitro and in vivo...
  85. ncbi request reprint Delta-24 increases the expression and activity of topoisomerase I and enhances the antiglioma effect of irinotecan
    Candelaria Gomez-Manzano
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Clin Cancer Res 12:556-62. 2006
    ..In this study, we sought to determine whether Delta-24 could sensitize glioma cells to the topoisomerase I inhibitor irinotecan (CPT-11) and to identify the mechanisms underlying this enhanced anticancer effect...
  86. ncbi request reprint The RB and p53 pathways in cancer
    Charles J Sherr
    Howard Hughes Medical Institute, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Cancer Cell 2:103-12. 2002
    ..Pinpointing the various ways by which the functions of RB and p53 are subverted in individual tumors should provide a rational basis for developing more refined tumor-specific therapies...
  87. ncbi request reprint Killing time for cancer cells
    Shoshana Klein
    Unit of Cellular Signalling, Department of Biological Chemistry, The Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Nat Rev Cancer 5:573-80. 2005
    ..Can cancer be cured, or will it have to be controlled as a chronic disease?..
  88. pmc DNA methylation analysis by digital bisulfite genomic sequencing and digital MethyLight
    Daniel J Weisenberger
    Department of Surgery, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA 90033, USA
    Nucleic Acids Res 36:4689-98. 2008
    ..Using digital MethyLight, we identified single-molecule, cancer-specific DNA hypermethylation events in the CpG islands of RUNX3, CLDN5 and FOXE1 present in plasma samples from breast cancer patients...
  89. ncbi request reprint Oncolytic adenoviruses as antiglioma agents
    Hong Jiang
    Department of Neuro Oncology, University of Texas MD Anderson Cancer Center, Box 316, Houston, TX 77030, USA
    Expert Rev Anticancer Ther 6:697-708. 2006
    ..In the near future, oncolytic adenoviruses need to be optimized to fully realize their potential as critical anticancer tools and, thus, improve the prognosis for patients with malignant gliomas...
  90. pmc A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
    Richard M Neve
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94270, USA
    Cancer Cell 10:515-27. 2006
    ..We show, using Trastuzumab (Herceptin) monotherapy as an example, that the system can be used to identify molecular features that predict or indicate response to targeted therapies or other physiological perturbations...

Research Grants3

  1. CANCER CENTER SUPPORT GRANT
    Frank McCormick; Fiscal Year: 2007
    ..Hematopoietic Malignancies Informatics Pediatric Malignancies Mouse Pathology Cell Cycling and Signaling Preclinical Therapeutics Cancer Genetics Mass Spectrometry Tobacco Control Biostatistics Clinical Research Support Services ..