Francis McCormack

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint The carbohydrate recognition domain of surfactant protein A mediates binding to the major surface glycoprotein of Pneumocystis carinii
    F X McCormack
    Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Biochemistry 36:8092-9. 1997
  2. ncbi request reprint Macrophage-independent fungicidal action of the pulmonary collectins
    Francis X McCormack
    Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA
    J Biol Chem 278:36250-6. 2003
  3. ncbi request reprint New concepts in collectin-mediated host defense at the air-liquid interface of the lung
    Francis X McCormack
    Division of Pulmonary and Critical Care Medicine, University of Cincinnati, Cincinnati, OH 45267 0564, USA
    Respirology 11:S7-10. 2006
  4. pmc Efficacy and safety of sirolimus in lymphangioleiomyomatosis
    Francis X McCormack
    University of Cincinnati, Cincinnati, OH, USA
    N Engl J Med 364:1595-606. 2011
  5. pmc The pulmonary collectins, SP-A and SP-D, orchestrate innate immunity in the lung
    Francis X McCormack
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45267 0564, USA
    J Clin Invest 109:707-12. 2002
  6. ncbi request reprint Pulmonary cysts consistent with lymphangioleiomyomatosis are common in women with tuberous sclerosis: genetic and radiographic analysis
    Francis McCormack
    Department of Pediatrics, Division of Pulmonary and Critical Care Medicine, University of Cincinnati, Cincinnati, OH 45267 0564, USA
    Chest 121:61S. 2002
  7. doi request reprint Lymphangioleiomyomatosis: a clinical update
    Francis X McCormack
    Division of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati, MSB 6053, 231 Albert Sabin Way, Cincinnati, OH 45267 0564, USA
    Chest 133:507-16. 2008
  8. ncbi request reprint Alanine mutagenesis of surfactant protein A reveals that lipid binding and pH-dependent liposome aggregation are mediated by the carbohydrate recognition domain
    F X McCormack
    Division of Pulmonary Critical Care Medicine, University of Cincinnati College of Medicine, Ohio, USA
    Biochemistry 36:13963-71. 1997
  9. ncbi request reprint Structure, processing and properties of surfactant protein A
    F X McCormack
    Division of Pulmonary and Critical Care Medicine, University of Cincinnati College of Medicine, 231 Bethesda Ave, Cincinnati, OH 45267 0564, USA
    Biochim Biophys Acta 1408:109-31. 1998
  10. ncbi request reprint Deletion mapping of N-terminal domains of surfactant protein A. The N-terminal segment is required for phospholipid aggregation and specific inhibition of surfactant secretion
    F X McCormack
    Division of Pulmonary Critical Care Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 274:3173-81. 1999

Research Grants

  1. The 2007 LAM Foundation Lymphangioleiomyomatosis International Research Conferenc
    Francis McCormack; Fiscal Year: 2007
  2. PHASE III TRIAL FO SIROLIMUS IN LYMPHANGIOLEIOMYLMATOSIS
    Francis McCormack; Fiscal Year: 2007
  3. Lymphangioleiomyomatosis Research Conference 2006
    Francis McCormack; Fiscal Year: 2006
  4. 2005 LAM Foundation Lymphangioleiomyomatosis Research
    Francis McCormack; Fiscal Year: 2005
  5. Novel Antioxidant Mechanisms of Surfactant Proteins
    Francis McCormack; Fiscal Year: 2006
  6. Lymphangioleimyomatosis Research Conference
    Francis McCormack; Fiscal Year: 2004
  7. Lymphangioleiomyomatosis Research Project
    Francis McCormack; Fiscal Year: 2003
  8. Lymphangioleiomyomatosis Research Project
    Francis McCormack; Fiscal Year: 2002
  9. SURFACTANT PROTEIN A IN PULMONARY HOST DEFENSE
    Francis McCormack; Fiscal Year: 2002
  10. PHASE III TRIAL FO SIROLIMUS IN LYMPHANGIOLEIOMYLMATOSIS
    Francis McCormack; Fiscal Year: 2009

Collaborators

Detail Information

Publications48

  1. ncbi request reprint The carbohydrate recognition domain of surfactant protein A mediates binding to the major surface glycoprotein of Pneumocystis carinii
    F X McCormack
    Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Biochemistry 36:8092-9. 1997
    ..Deletion of the N-linked oligosaccharides from SP-A by mutagenesis of the consensus sequences for glycosylation had no effect on binding. We conclude that the CRD mediates the binding of SP-A to oligosaccharides attached to MSG...
  2. ncbi request reprint Macrophage-independent fungicidal action of the pulmonary collectins
    Francis X McCormack
    Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA
    J Biol Chem 278:36250-6. 2003
    ....
  3. ncbi request reprint New concepts in collectin-mediated host defense at the air-liquid interface of the lung
    Francis X McCormack
    Division of Pulmonary and Critical Care Medicine, University of Cincinnati, Cincinnati, OH 45267 0564, USA
    Respirology 11:S7-10. 2006
    ..Recent studies suggest that these proteins have a direct effect on the growth and viability of Gram-negative bacteria, Mycoplasma pneumoniae and Histoplasma capsulatum...
  4. pmc Efficacy and safety of sirolimus in lymphangioleiomyomatosis
    Francis X McCormack
    University of Cincinnati, Cincinnati, OH, USA
    N Engl J Med 364:1595-606. 2011
    ..Sirolimus (also called rapamycin) inhibits mTOR and has shown promise in phase 1-2 trials involving patients with LAM...
  5. pmc The pulmonary collectins, SP-A and SP-D, orchestrate innate immunity in the lung
    Francis X McCormack
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Children s Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45267 0564, USA
    J Clin Invest 109:707-12. 2002
  6. ncbi request reprint Pulmonary cysts consistent with lymphangioleiomyomatosis are common in women with tuberous sclerosis: genetic and radiographic analysis
    Francis McCormack
    Department of Pediatrics, Division of Pulmonary and Critical Care Medicine, University of Cincinnati, Cincinnati, OH 45267 0564, USA
    Chest 121:61S. 2002
  7. doi request reprint Lymphangioleiomyomatosis: a clinical update
    Francis X McCormack
    Division of Pulmonary, Critical Care and Sleep Medicine, University of Cincinnati, MSB 6053, 231 Albert Sabin Way, Cincinnati, OH 45267 0564, USA
    Chest 133:507-16. 2008
    ..Multicenter clinical trials based on several well-defined molecular targets are currently underway in the United States and Europe...
  8. ncbi request reprint Alanine mutagenesis of surfactant protein A reveals that lipid binding and pH-dependent liposome aggregation are mediated by the carbohydrate recognition domain
    F X McCormack
    Division of Pulmonary Critical Care Medicine, University of Cincinnati College of Medicine, Ohio, USA
    Biochemistry 36:13963-71. 1997
    ....
  9. ncbi request reprint Structure, processing and properties of surfactant protein A
    F X McCormack
    Division of Pulmonary and Critical Care Medicine, University of Cincinnati College of Medicine, 231 Bethesda Ave, Cincinnati, OH 45267 0564, USA
    Biochim Biophys Acta 1408:109-31. 1998
    ..Recently developed genetically manipulated animal models are beginning to clarify the critical physiological roles for SP-A in the normal lung, and in the pathophysiology of pulmonary disease...
  10. ncbi request reprint Deletion mapping of N-terminal domains of surfactant protein A. The N-terminal segment is required for phospholipid aggregation and specific inhibition of surfactant secretion
    F X McCormack
    Division of Pulmonary Critical Care Medicine, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Biol Chem 274:3173-81. 1999
    ....
  11. ncbi request reprint The collagen-like region of surfactant protein A (SP-A) is required for correction of surfactant structural and functional defects in the SP-A null mouse
    M Ikegami
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 276:38542-8. 2001
    ....
  12. ncbi request reprint Immunosuppressed surfactant protein A-deficient mice have increased susceptibility to Pneumocystis carinii infection
    M J Linke
    Research Service, Department of Veterans Affairs Medical Center, and Divisions of Infectious Diseases and Pulmonary Critical Care Medicine, University of Cincinnati, Cincinnati, OH 45220, USA
    J Infect Dis 183:943-52. 2001
    ..carinii to the macrophages. Thus, SP-A plays a role in host defense against P. carinii in vivo, perhaps by functioning as a nonimmune opsonin...
  13. ncbi request reprint Three-dimensional structure of rat surfactant protein A trimers in association with phospholipid monolayers
    N Palaniyar
    Department of Internal Medicine, University of Cincinnati, Ohio 45267 0564, USA
    Biochemistry 39:6310-6. 2000
    ....
  14. ncbi request reprint Functional mapping of surfactant protein A
    F X McCormack
    Division of Pulmonary and Critical Case Medicine, Univ of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0564, USA
    Pediatr Pathol Mol Med 20:293-318. 2001
    ..My review focuses on the putative biological functions of SP-A that are supported by experiments in mammals and on the structural basis of SP-A function...
  15. ncbi request reprint Surfactant lipid peroxidation damages surfactant protein A and inhibits interactions with phospholipid vesicles
    A I Kuzmenko
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Cincinnati School of Medicine, Cincinnati, OH 45267, USA
    J Lipid Res 45:1061-8. 2004
    ..We conclude that exposure of SP-A to LPO results in oxidative modification and functional inactivation of SP-A by phospholipid radicals...
  16. ncbi request reprint Mutational and radiographic analysis of pulmonary disease consistent with lymphangioleiomyomatosis and micronodular pneumocyte hyperplasia in women with tuberous sclerosis
    D N Franz
    Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Am J Respir Crit Care Med 164:661-8. 2001
    ..This prospective analysis demonstrates that cystic and nodular pulmonary changes consistent with LAM and MMPH are common in women with TSC...
  17. ncbi request reprint Patient perspectives on management of pneumothorax in lymphangioleiomyomatosis
    Lisa R Young
    Department of Medicine, University of Cincinnati, Division of Pulmonary and Critical Care, Cincinnati, OH 45267 0564, USA
    Chest 129:1267-73. 2006
    ..Study design and participants: A 23-item questionnaire evaluating opinions of pneumothorax treatment was distributed to 615 patients in the LAM Foundation patient database, with a response rate of 52%...
  18. pmc Lung-restricted macrophage activation in the pearl mouse model of Hermansky-Pudlak syndrome
    Lisa R Young
    Department of Medicine, Division of Pulmonary and Critical Care, University of Cincinnati, OH 45267, USA
    J Immunol 176:4361-8. 2006
    ..Similar abnormalities were identified in AMs and BAL from another HPS model, pale ear HPS1 mice. We conclude that the lungs of HPS mice exhibit hyperresponsiveness to LPS and constitutive and organ-specific macrophage activation...
  19. ncbi request reprint Neither SP-A nor NH2-terminal domains of SP-A can substitute for SP-D in regulation of alveolar homeostasis
    Liqian Zhang
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, OH 45229, USA
    Am J Physiol Lung Cell Mol Physiol 291:L181-90. 2006
    ....
  20. pmc Pulmonary collectins selectively permeabilize model bacterial membranes containing rough lipopolysaccharide
    Alexander I Kuzmenko
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, Ohio 45267 0564, USA
    Biochemistry 45:2679-85. 2006
    ..Incorporation of cholesterol into the membrane enhances resistance to permeabilization by SP-A, most likely by increasing the packing density and membrane rigidity...
  21. ncbi request reprint Pleural disease in lymphangioleiomyomatosis
    Khalid F Almoosa
    Department of Internal Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0564, USA
    Clin Chest Med 27:355-68. 2006
    ..Because of the rarity of the LAM, few data exist on whether the occurrence of pleural complications in LAM accelerates functional decline or portends a worse prognosis...
  22. ncbi request reprint Correction of pulmonary abnormalities in Sftpd-/- mice requires the collagenous domain of surfactant protein D
    Paul S Kingma
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio 45229 3039, USA
    J Biol Chem 281:24496-505. 2006
    ..The collagen domain of SP-D is required for the regulation of pulmonary macrophage activation, airspace remodeling, and surfactant lipid homeostasis...
  23. pmc Air travel in women with lymphangioleiomyomatosis
    Stacey Pollock-Barziv
    Women s College Research Institute, Women s College Hospital, Toronto, Ontario, Canada
    Thorax 62:176-80. 2007
    ..A questionnaire-based evaluation of air travel in patients with LAM was conducted to determine experiences aboard commercial aircraft...
  24. pmc Molecular pathogenesis of lymphangioleiomyomatosis: lessons learned from orphans
    Stephen C Juvet
    National Jewish Medical and Research Center, 1400 Jackson Street, Denver, CO 80206, USA
    Am J Respir Cell Mol Biol 36:398-408. 2007
    ..This knowledge served as the foundation for novel therapeutic approaches that are currently being used in human clinical trials...
  25. ncbi request reprint Management of pneumothorax in lymphangioleiomyomatosis: effects on recurrence and lung transplantation complications
    Khalid F Almoosa
    Division of Pulmonary and Critical Care, University of Cincinnati, Cincinnati, OH 45267 0564, USA
    Chest 129:1274-81. 2006
    ..Chemical or surgical pleurodesis are often required to prevent recurrence. However, their efficacy in LAM is unclear, and whether they contribute to perioperative complications during lung transplantation is uncertain...
  26. ncbi request reprint The resident scholar program: a research training opportunity for internal medicine house staff
    Abigail B Byrnes
    University of Cincinnati, Cincinnati, Ohio, USA
    J Cancer Educ 22:47-9. 2007
    ..The Resident Scholar Program (RSP) at the University of Cincinnati, Department of Internal Medicine was created to overcome these challenges...
  27. pmc Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
    John J Bissler
    Division of Nephrology and Hypertension, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229 3039, USA
    N Engl J Med 358:140-51. 2008
    ..The drug sirolimus suppresses mTOR signaling...
  28. pmc Diagnostic potential of serum VEGF-D for lymphangioleiomyomatosis
    Lisa R Young
    N Engl J Med 358:199-200. 2008
  29. pmc Surfactant proteins A and D inhibit the growth of Gram-negative bacteria by increasing membrane permeability
    Huixing Wu
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA
    J Clin Invest 111:1589-602. 2003
    ....
  30. ncbi request reprint Pulmonary surfactant protein A up-regulates activity of the mannose receptor, a pattern recognition receptor expressed on human macrophages
    Alison A Beharka
    Veterans Affairs Medical Center and Division of Infectious Diseases, Department of Medicine and Microbiology, Interdisciplinary Immunology Program, University of Iowa, Iowa City, IA 52242, USA
    J Immunol 169:3565-73. 2002
    ..SP-A contributes to the alternative activation state of the AM in the lung...
  31. ncbi request reprint Recurrent lymphangiomyomatosis after transplantation: genetic analyses reveal a metastatic mechanism
    Magdalena Karbowniczek
    Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111, USA
    Am J Respir Crit Care Med 167:976-82. 2003
    ..In addition, the patient had no evidence of a renal angiomyolipoma at autopsy and therefore demonstrated for the first time that somatic TSC2 mutations cause LAM in patients without angiomyolipomas...
  32. ncbi request reprint Surfactant protein A inhibits lipopolysaccharide-induced in vivo production of interleukin-10 by mononuclear phagocytes during lung inflammation
    Sophie Chabot
    Unité de Défense Innée et Inflammation, Unité Associée Institut Pasteur Institut National de la Santé et de la Recherche Médicale, U485, Paris, France
    Am J Respir Cell Mol Biol 28:347-53. 2003
    ..In summary, this study demonstrates for the first time an in vivo inhibitory role of SP-A on the anti-inflammatory activity of MP, through inhibition of IL-10 production...
  33. ncbi request reprint Pulmonary surfactant protein-A (SP-A) restores the surface properties of surfactant after oxidation by a mechanism that requires the Cys6 interchain disulfide bond and the phospholipid binding domain
    Karina Rodriguez Capote
    Departments of Obstetrics Gynecology and Biochemistry, Canadian Institutes of Health Research Group in Fetal and Neonatal Health and Development, University of Western Ontario, London N6A 5A5, Canada
    J Biol Chem 278:20461-74. 2003
    ....
  34. ncbi request reprint Crystal structure of trimeric carbohydrate recognition and neck domains of surfactant protein A
    James F Head
    Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 278:43254-60. 2003
    ....
  35. ncbi request reprint Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4
    Loic Guillot
    Unité de Défense Innée et Inflammation, Institut Pasteur, Institut National de la Sante et de la Recherche Medicale, Unité 485, Paris, France
    J Immunol 168:5989-92. 2002
    ..These findings support the concept that TLR4 is a pattern recognition receptor that signals in response to both foreign pathogens and endogenous host mediators...
  36. ncbi request reprint The role of pulmonary collectin N-terminal domains in surfactant structure, function, and homeostasis in vivo
    Nades Palaniyar
    Division of Pulmonary Critical Care Medicine, Department of Medicine, Children s Hospital Research Foundation, University of Cincinnati School of Medicine, Cincinnati, OH 45267 0564, USA
    J Biol Chem 277:26971-9. 2002
    ....
  37. ncbi request reprint Bordetella pertussis lipopolysaccharide resists the bactericidal effects of pulmonary surfactant protein A
    Lyndsay M Schaeffer
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, Cincinnati, OH 45267, USA
    J Immunol 173:1959-65. 2004
    ..pertussis toxin that has been shown to depress neutrophil activity. We conclude that the LPS of wild-type B. pertussis shields the bacteria from SP-A-mediated clearance, possibly by sterically limiting access to the lipid A region...
  38. pmc Interactions of pulmonary collectins with Bordetella bronchiseptica and Bordetella pertussis lipopolysaccharide elucidate the structural basis of their antimicrobial activities
    Lyndsay M Schaeffer
    Department of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati, 231 Albert Sabin Way, ML 0524, Cincinnati, OH 45267, USA
    Infect Immun 72:7124-30. 2004
    ..We conclude that the terminal trisaccharide protects Bordetella species from the bactericidal functions of SP-A and SP-D. The O antigen and palmitoylated lipid A of B. bronchiseptica play no role in this resistance...
  39. ncbi request reprint Surfactant protein A is a principal and oxidation-sensitive microbial permeabilizing factor in the alveolar lining fluid
    Alexander I Kuzmenko
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Cincinnati School of Medicine, Cincinnati, Ohio 45267 0564, USA
    J Biol Chem 280:25913-9. 2005
    ....
  40. ncbi request reprint Pulmonary surfactant protein A activates a phosphatidylinositol 3-kinase/calcium signal transduction pathway in human macrophages: participation in the up-regulation of mannose receptor activity
    Alison A Beharka
    Interdisciplinary Program in Immunology and Department of Internal Medicine, University of Iowa, Iowa City, IA 52240, USA
    J Immunol 175:2227-36. 2005
    ..These studies provide further evidence that SP-A produced in the lung plays a role in modulating macrophage biology, thereby contributing to the alternative activation state of the alveolar macrophage...
  41. ncbi request reprint Pulmonary surfactant and inflammation in septic adult mice: role of surfactant protein A
    Jaret L Malloy
    Department of Physiology, Lawson Health Research Institute, University of Western Ontario, London, Ontario, Canada N6A 4V2
    J Appl Physiol 92:809-16. 2002
    ..In addition, we did not detect a role for SP-A in regulating surfactant phospholipid pool sizes or pulmonary inflammation in septic mice...
  42. ncbi request reprint S-LAM in a man?
    Francis X McCormack
    Am J Respir Crit Care Med 176:3-5. 2007
  43. ncbi request reprint Antimicrobial activity of native and synthetic surfactant protein B peptides
    Marnie A Ryan
    Division of Pulmonary Biology, Cincinnati Children s Hospital Medical Center, and University of Cincinnati College of Medicine, OH 45229 3039, USA
    J Immunol 176:416-25. 2006
    ..These results suggest that the role of endogenous SP-B in host defense may be limited; however, synthetic peptides derived from SP-B may be useful in the treatment of bacterial pneumonias...
  44. pmc Lymphangioleiomyomatosis
    Francis X McCormack
    Division of Pulmonary and Critical Care, The University of Cincinnati School of Medicine, Cincinnati, Ohio, USA
    MedGenMed 8:15. 2006
  45. ncbi request reprint Lymphangioleiomyomatosis: insights about, and from, a rare disease
    Kathy E Sietsema
    Am J Respir Crit Care Med 168:1405-6. 2003
  46. ncbi request reprint Pulmonary surfactant protein a inhibits macrophage reactive oxygen intermediate production in response to stimuli by reducing NADPH oxidase activity
    Joy E Crowther
    Interdisciplinary Graduate Program in Immunology, University of Iowa, Iowa City, IA 52240, USA
    J Immunol 172:6866-74. 2004
    ..These data support an anti-inflammatory role for SP-A in pulmonary homeostasis by inhibiting Mphi production of ROI through a reduction in NADPH oxidase activity...
  47. pmc The NHLBI lymphangioleiomyomatosis registry: characteristics of 230 patients at enrollment
    Jay H Ryu
    Division of Pulmonary and Critical Care Medicine, Desk East 18, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA
    Am J Respir Crit Care Med 173:105-11. 2006
    ..Previous descriptions of clinical characteristics of subjects with lymphangioleiomyomatosis have been based on a limited number of patients...
  48. pmc Susceptibility of Hermansky-Pudlak mice to bleomycin-induced type II cell apoptosis and fibrosis
    Lisa R Young
    University of Cincinnati, Pulmonary, Critical Care, and Sleep Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Am J Respir Cell Mol Biol 37:67-74. 2007
    ..We conclude that the trafficking abnormalities in HPS promote alveolar apoptosis and pulmonary fibrosis in response to bleomycin challenge...

Research Grants19

  1. The 2007 LAM Foundation Lymphangioleiomyomatosis International Research Conferenc
    Francis McCormack; Fiscal Year: 2007
    ....
  2. PHASE III TRIAL FO SIROLIMUS IN LYMPHANGIOLEIOMYLMATOSIS
    Francis McCormack; Fiscal Year: 2007
    ..Patient safety will be monitored by an NIH Data Safety Monitoring Board (DSMB). The MILES trial is designed as a pivotal study to determine if sirolimus is effective in stabilizing or improving lung function in patients with LAM. ..
  3. Lymphangioleiomyomatosis Research Conference 2006
    Francis McCormack; Fiscal Year: 2006
    ....
  4. 2005 LAM Foundation Lymphangioleiomyomatosis Research
    Francis McCormack; Fiscal Year: 2005
    ..abstract_text> ..
  5. Novel Antioxidant Mechanisms of Surfactant Proteins
    Francis McCormack; Fiscal Year: 2006
    ..The results will provide important insights into the roles of the surfactant proteins in preventing oxidative lung disease and may be useful for the design of novel recombinant proteins and peptides of therapeutic value. ..
  6. Lymphangioleimyomatosis Research Conference
    Francis McCormack; Fiscal Year: 2004
    ..abstract_text> ..
  7. Lymphangioleiomyomatosis Research Project
    Francis McCormack; Fiscal Year: 2003
    ..abstract_text> ..
  8. Lymphangioleiomyomatosis Research Project
    Francis McCormack; Fiscal Year: 2002
    ..Efforts have been made to attract established investigators from related disciplines who can complement the expertise of the LAM investigators. ..
  9. SURFACTANT PROTEIN A IN PULMONARY HOST DEFENSE
    Francis McCormack; Fiscal Year: 2002
    ..These studies will elucidate the role of SP-A in the innate immune defense of the lung, and may assist in the design of optimal antimicrobial strategies. ..
  10. PHASE III TRIAL FO SIROLIMUS IN LYMPHANGIOLEIOMYLMATOSIS
    Francis McCormack; Fiscal Year: 2009
    ..Patient safety will be monitored by an NIH Data Safety Monitoring Board (DSMB). The MILES trial is designed as a pivotal study to determine if sirolimus is effective in stabilizing or improving lung function in patients with LAM. ..