Janet R McColm

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. pmc Exogenous leukemia inhibitory factor (LIF) attenuates retinal vascularization reducing cell proliferation not apoptosis
    Janet R McColm
    Department of Ophthalmology, University of North Carolina, 6135 Neuroscience Research Building, 103 Mason Farm Road, Chapel Hill, NC 27599 7041, USA
    Exp Eye Res 83:438-46. 2006
  2. ncbi request reprint Hypoxic oxygen fluctuations produce less severe retinopathy than hyperoxic fluctuations in a rat model of retinopathy of prematurity
    Janet R McColm
    Child Life and Health, Reproductive and Developmental Sciences, University of Edinburgh, Edingurgh, United Kingdom
    Pediatr Res 55:107-13. 2004
  3. pmc VEGF isoforms and their expression after a single episode of hypoxia or repeated fluctuations between hyperoxia and hypoxia: relevance to clinical ROP
    Janet R McColm
    Department of Ophthalmology, University of North Carolina, Chapel Hill, NC 27599 7041, USA
    Mol Vis 10:512-20. 2004
  4. pmc Triamcinolone reduces neovascularization, capillary density and IGF-1 receptor phosphorylation in a model of oxygen-induced retinopathy
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, 6109A Neuroscience Research Building, Chapel Hill, NC 27599, USA
    Invest Ophthalmol Vis Sci 47:4975-82. 2006
  5. ncbi request reprint Characterization of barrier properties and inducible VEGF expression of several types of retinal pigment epithelium in medium-term culture
    Pete Geisen
    Department of Ophthalmology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Curr Eye Res 31:739-48. 2006
  6. ncbi request reprint Comparison of retinal outcomes after scleral buckle or lens-sparing vitrectomy for stage 4 retinopathy of prematurity
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599 7040, USA
    Retina 24:753-7. 2004
  7. ncbi request reprint Choroidal endothelial cells transmigrate across the retinal pigment epithelium but do not proliferate in response to soluble vascular endothelial growth factor
    Pete Geisen
    Department of Ophthalmology, University of North Carolina Chapel Hill, 103 Mason Farm Road, CB No 7041, 6135 NSRB, Chapel Hill, NC 27599, USA
    Exp Eye Res 82:608-19. 2006
  8. pmc Fibrovascular organization in the vitreous following laser for ROP: implications for prognosis
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, NC 27599 7040, USA
    Retina 26:S24-31. 2006
  9. ncbi request reprint Retinal pigment epithelium and endothelial cell interaction causes retinal pigment epithelial barrier dysfunction via a soluble VEGF-dependent mechanism
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, 5109D Bioinformatics Building, 130 Mason Farm Road, CB 7040, Chapel Hill, NC 27599 7040, USA
    Exp Eye Res 77:593-9. 2003
  10. pmc Retinal features predictive of progressive stage 4 retinopathy of prematurity
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Retina 24:237-41. 2004

Collaborators

Detail Information

Publications15

  1. pmc Exogenous leukemia inhibitory factor (LIF) attenuates retinal vascularization reducing cell proliferation not apoptosis
    Janet R McColm
    Department of Ophthalmology, University of North Carolina, 6135 Neuroscience Research Building, 103 Mason Farm Road, Chapel Hill, NC 27599 7041, USA
    Exp Eye Res 83:438-46. 2006
    ..Antibody to LIF restored the cell counts to untreated levels. LIF reduced the number of cells in S phase. LIF attenuates retinal vascular development in vivo through growth arrest, and not apoptosis, of endothelial cells...
  2. ncbi request reprint Hypoxic oxygen fluctuations produce less severe retinopathy than hyperoxic fluctuations in a rat model of retinopathy of prematurity
    Janet R McColm
    Child Life and Health, Reproductive and Developmental Sciences, University of Edinburgh, Edingurgh, United Kingdom
    Pediatr Res 55:107-13. 2004
    ..Rats raised in a relatively hypoxic but variable oxygen environment develop less severe retinal vascular abnormalities than those raised in variable oxygen around higher oxygen means...
  3. pmc VEGF isoforms and their expression after a single episode of hypoxia or repeated fluctuations between hyperoxia and hypoxia: relevance to clinical ROP
    Janet R McColm
    Department of Ophthalmology, University of North Carolina, Chapel Hill, NC 27599 7041, USA
    Mol Vis 10:512-20. 2004
    ..We also determined whether pigment epithelium-derived factor (PEDF) was dysregulated by oxygen fluctuations perhaps contributing to a delay in normal retinal vascular development...
  4. pmc Triamcinolone reduces neovascularization, capillary density and IGF-1 receptor phosphorylation in a model of oxygen-induced retinopathy
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, 6109A Neuroscience Research Building, Chapel Hill, NC 27599, USA
    Invest Ophthalmol Vis Sci 47:4975-82. 2006
    ..To study the effects of intravitreous triamcinolone acetonide (TA) on neovascularization (NV), capillary density, and retinal endothelial cell (REC) viability in a model of oxygen-induced retinopathy (OIR)...
  5. ncbi request reprint Characterization of barrier properties and inducible VEGF expression of several types of retinal pigment epithelium in medium-term culture
    Pete Geisen
    Department of Ophthalmology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Curr Eye Res 31:739-48. 2006
    ..To investigate and compare the characteristics of four different types of retinal pigment epithelium (RPE) cells cultured for 2 to 5 weeks to provide guidance when choosing RPE cells for experimentation...
  6. ncbi request reprint Comparison of retinal outcomes after scleral buckle or lens-sparing vitrectomy for stage 4 retinopathy of prematurity
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599 7040, USA
    Retina 24:753-7. 2004
    ..To compare anatomic outcomes after lens-sparing vitrectomy (LSV) or scleral buckle (SB) for stage 4 retinopathy of prematurity (ROP)...
  7. ncbi request reprint Choroidal endothelial cells transmigrate across the retinal pigment epithelium but do not proliferate in response to soluble vascular endothelial growth factor
    Pete Geisen
    Department of Ophthalmology, University of North Carolina Chapel Hill, 103 Mason Farm Road, CB No 7041, 6135 NSRB, Chapel Hill, NC 27599, USA
    Exp Eye Res 82:608-19. 2006
    ..These findings may have relevance to the transformation of occult CNV into CNV within the neurosensory retina in AMD...
  8. pmc Fibrovascular organization in the vitreous following laser for ROP: implications for prognosis
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, NC 27599 7040, USA
    Retina 26:S24-31. 2006
    ..To study associations between surgical outcome and mean postmenstrual age (PMA) when fibrovascular organization is detected between vascular and avascular retina following laser for acute retinopathy of prematurity (ROP)...
  9. ncbi request reprint Retinal pigment epithelium and endothelial cell interaction causes retinal pigment epithelial barrier dysfunction via a soluble VEGF-dependent mechanism
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, 5109D Bioinformatics Building, 130 Mason Farm Road, CB 7040, Chapel Hill, NC 27599 7040, USA
    Exp Eye Res 77:593-9. 2003
    ..To investigate the effect of endothelial cells (EC) on the barrier function of the retinal pigment epithelium (RPE)...
  10. pmc Retinal features predictive of progressive stage 4 retinopathy of prematurity
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Retina 24:237-41. 2004
    ..To determine the retinal features predictive of progressive stage 4 retinopathy of prematurity (ROP) after laser treatment for threshold ROP...
  11. ncbi request reprint Long-term vision results measured with Teller Acuity Cards and a new Light Perception/Projection Scale after management of late stages of retinopathy of prematurity
    M Elizabeth Hartnett
    Department of Ophthalmology, University of North Carolina, Chapel Hill 27599 7040, USA
    Arch Ophthalmol 121:991-6. 2003
    ....
  12. pmc Orientation of endothelial cell division is regulated by VEGF signaling during blood vessel formation
    Gefei Zeng
    Department of Biology, University of North Carolina at Chapel Hill 27599, USA
    Blood 109:1345-52. 2007
    ....
  13. doi request reprint Myelin expression is altered in the brains of neonatal rats reared in a fluctuating oxygen atmosphere
    Kofi Sedowofia
    Child Life and Health Section, Division of Reproductive and Developmental Sciences, University of Edinburgh, Edinburgh, UK
    Neonatology 94:113-22. 2008
    ..Preterm infants receiving supplemental oxygen therapy experience frequent fluctuations in their blood oxygen levels, the magnitude of which has been associated with the incidence and severity of retinopathy of prematurity in such infants...
  14. ncbi request reprint Diode laser for ROP
    Mary Elizabeth Hartnett
    Ophthalmology 112:1636; author reply 1636. 2005
  15. ncbi request reprint Duration of effect of intravenous antibiotics on spirometry and sputum cytokines in children with cystic fibrosis
    Steven Cunningham
    Department of Child Life and Health, University of Edinburgh, Edinburgh, UK
    Pediatr Pulmonol 36:43-8. 2003
    ..In addition, assessment of cytokines in subsequent exacerbations does not show a similar pattern of response to treatment...