D McCollum

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Crosstalk between NDR kinase pathways coordinates cell cycle dependent actin rearrangements
    Sneha Gupta
    Department of Microbiology and Physiological Systems, and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cell Div 6:19. 2011
  2. doi request reprint Cytokinesis: ER keeps Mid1 in the middle
    Dannel McCollum
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 377 Plantation St, Worcester, MA 01605, USA
    Curr Biol 20:R484-6. 2010
  3. ncbi request reprint Cytokinesis: breaking the ties that bind
    Dannel McCollum
    University of Massachusetts Medical School, Biotech 4, 377 Plantation Street, Worcester, Massachusetts 01605, USA
    Curr Biol 15:R998-1000. 2005
  4. ncbi request reprint Timing is everything: regulation of mitotic exit and cytokinesis by the MEN and SIN
    D McCollum
    Dept of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Trends Cell Biol 11:89-95. 2001
  5. ncbi request reprint Cytokinesis: the central spindle takes center stage
    Dannel McCollum
    University of Massachusetts Medical School, Biotech 4, 377 Plantation Street, Worcester, Massachusetts 01605, USA
    Curr Biol 14:R953-5. 2004
  6. ncbi request reprint Interaction between the noncatalytic region of Sid1p kinase and Cdc14p is required for full catalytic activity and localization of Sid1p
    D A Guertin
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 276:28185-9. 2001
  7. ncbi request reprint Fission yeast Clp1p phosphatase regulates G2/M transition and coordination of cytokinesis with cell cycle progression
    S Trautmann
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Biol 11:931-40. 2001
  8. pmc The role of the sid1p kinase and cdc14p in regulating the onset of cytokinesis in fission yeast
    D A Guertin
    Department of Molecular Genetics, University of Massachusetts Medical School, 377 Plantation Street, Worcester, MA 01605, USA
    EMBO J 19:1803-15. 2000
  9. pmc Sid2p, a spindle pole body kinase that regulates the onset of cytokinesis
    C A Sparks
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Cell Biol 146:777-90. 1999
  10. ncbi request reprint Mob1p interacts with the Sid2p kinase and is required for cytokinesis in fission yeast
    M C Hou
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Biol 10:619-22. 2000

Research Grants

  1. REGULATION OF CYTOKINESIS IN FISSION YEAST
    Dannel McCollum; Fiscal Year: 2007
  2. Regulation anf Function of Clp 1p Protein Phosphatase
    Dannel McCollum; Fiscal Year: 2006
  3. Regulation and function of the Clp 1p protein phosphatase
    Dannel McCollum; Fiscal Year: 2007
  4. Regulation and function of the Clp 1p protein phosphatase
    Dannel McCollum; Fiscal Year: 2010
  5. REGULATION OF CYTOKINESIS IN FISSION YEAST
    Dannel McCollum; Fiscal Year: 2006
  6. REGULATION OF CYTOKINESIS IN FISSION YEAST
    Dannel McCollum; Fiscal Year: 2010

Collaborators

  • K L Gould
  • Viesturs Simanis
  • L Chang
  • G Sluder
  • S Doxsey
  • Seth Field
  • Dai Hirata
  • Jim Karagiannis
  • Jianhua Liu
  • Hongyan Wang
  • Susanne Trautmann
  • Quan Wen Jin
  • Chun Ti Chen
  • Ming Chin Hou
  • David A Guertin
  • Sneha Gupta
  • Samriddha Ray
  • Sung Hugh Choi
  • Dawn M Clifford
  • D A Guertin
  • Juan Carlos García-Cortés
  • Anna Feoktistova
  • Jun Song Chen
  • Marie Pierre Péli-Gulli
  • Mohan K Balasubramanian
  • Mithilesh Mishra
  • Prasenjit Mitra
  • S Trautmann
  • Kazunori Kume
  • M C Hou
  • Wanzhong Ge
  • Mohan Balasubramanian
  • John R Yates
  • Ali Sarkeshik
  • Iain Mcleod
  • Benjamin A Wolfe
  • C A Sparks
  • Rachel H Roberts
  • Young Sam Shim
  • Mian Zhou
  • Andrea Bimbo
  • Monica L Kerr
  • Alonzo H Ross
  • John J Nunnari
  • Gregory M Hendricks
  • Lucia E Rameh
  • Lewis C Cantley
  • Maria P Ivshina
  • Yingjie Zhang
  • Srividya Rajagopalan
  • Fulvia Verde
  • David J Wiley
  • Srinivas Venkatram
  • B A Wolfe
  • P Jorgensen
  • M Tyers
  • F Irshad
  • J Salek
  • M Morphew

Detail Information

Publications33

  1. pmc Crosstalk between NDR kinase pathways coordinates cell cycle dependent actin rearrangements
    Sneha Gupta
    Department of Microbiology and Physiological Systems, and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cell Div 6:19. 2011
    ..Given the conservation of NDR kinase signaling pathways, our results may define general mechanisms by which these pathways are coordinated in higher organisms...
  2. doi request reprint Cytokinesis: ER keeps Mid1 in the middle
    Dannel McCollum
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, 377 Plantation St, Worcester, MA 01605, USA
    Curr Biol 20:R484-6. 2010
    ..A new study has shown an unexpected role for cortically associated endoplasmic reticulum in positioning the site of cell division...
  3. ncbi request reprint Cytokinesis: breaking the ties that bind
    Dannel McCollum
    University of Massachusetts Medical School, Biotech 4, 377 Plantation Street, Worcester, Massachusetts 01605, USA
    Curr Biol 15:R998-1000. 2005
    ..It has been unclear how cells complete cell division and resolve membrane connections to bring about cell separation. Recent work has shown that targeted secretion to the midbody is required to complete cell division...
  4. ncbi request reprint Timing is everything: regulation of mitotic exit and cytokinesis by the MEN and SIN
    D McCollum
    Dept of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Trends Cell Biol 11:89-95. 2001
    ....
  5. ncbi request reprint Cytokinesis: the central spindle takes center stage
    Dannel McCollum
    University of Massachusetts Medical School, Biotech 4, 377 Plantation Street, Worcester, Massachusetts 01605, USA
    Curr Biol 14:R953-5. 2004
    ..Recent studies have shed new light on how assembly of the central spindle is regulated, and also support a role for both the central spindle and astral microtubules in cytokinesis in animal cells...
  6. ncbi request reprint Interaction between the noncatalytic region of Sid1p kinase and Cdc14p is required for full catalytic activity and localization of Sid1p
    D A Guertin
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 276:28185-9. 2001
    ..We conclude that Cdc14p positively regulates the Sid1p kinase by binding the noncatalytic carboxyl-terminal region of the protein...
  7. ncbi request reprint Fission yeast Clp1p phosphatase regulates G2/M transition and coordination of cytokinesis with cell cycle progression
    S Trautmann
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Biol 11:931-40. 2001
    ....
  8. pmc The role of the sid1p kinase and cdc14p in regulating the onset of cytokinesis in fission yeast
    D A Guertin
    Department of Molecular Genetics, University of Massachusetts Medical School, 377 Plantation Street, Worcester, MA 01605, USA
    EMBO J 19:1803-15. 2000
    ....
  9. pmc Sid2p, a spindle pole body kinase that regulates the onset of cytokinesis
    C A Sparks
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Cell Biol 146:777-90. 1999
    ....
  10. ncbi request reprint Mob1p interacts with the Sid2p kinase and is required for cytokinesis in fission yeast
    M C Hou
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Biol 10:619-22. 2000
    ....
  11. ncbi request reprint Centrosomes in cellular regulation
    Stephen Doxsey
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Annu Rev Cell Dev Biol 21:411-34. 2005
    ..These new liaisons between MTOCs and cellular regulation are the focus of this review. Elucidation of these and other previously unappreciated centrosome functions promises to yield exciting scientific discovery for some time to come...
  12. ncbi request reprint The S. pombe Cdc14-like phosphatase Clp1p regulates chromosome biorientation and interacts with Aurora kinase
    Susanne Trautmann
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical Center, Worcester, MA 01605, USA
    Dev Cell 7:755-62. 2004
    ..Together, these results suggest that Clp1p/Flp1p has a role in repairing mono-orientation of sister kinetochores...
  13. pmc Phosphorylation state defines discrete roles for monopolin in chromosome attachment and spindle elongation
    Sung Hugh Choi
    Department of Molecular Genetics and Microbiology and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Biol 19:985-95. 2009
    ..It is unknown how oscillations in Cdk1 activity drive the dramatic changes in chromosome and spindle dynamics that occur at the metaphase/anaphase transition...
  14. pmc Proper timing of cytokinesis is regulated by Schizosaccharomyces pombe Etd1
    Juan Carlos García-Cortés
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Cell Biol 186:739-53. 2009
    ..Asymmetric activation of Spg1 is crucial for timely inactivation of the SIN. Together, these results suggest a mechanism whereby cell asymmetry is used to monitor cytoplasmic partitioning to turn off cytokinesis signaling...
  15. ncbi request reprint Dma1 prevents mitotic exit and cytokinesis by inhibiting the septation initiation network (SIN)
    David A Guertin
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester 01605, USA
    Dev Cell 3:779-90. 2002
    ..Dma1p itself localizes to spindle pole bodies through interaction with Sid4p. Our observations suggest that Dma1p functions to prevent mitotic exit and cytokinesis during spindle checkpoint arrest by inhibiting SIN signaling...
  16. ncbi request reprint Molecular biology. The mad ways of meiosis
    G Sluder
    Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Science 289:254-5. 2000
    ..One of the components of this meiotic spindle checkpoint turns out to be Mad2, which gives the signal to halt meiosis if it looks like unequal chromosome segregation is taking place...
  17. ncbi request reprint S. pombe FEAR protein orthologs are not required for release of Clp1/Flp1 phosphatase from the nucleolus during mitosis
    Chun Ti Chen
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Sci 119:4462-6. 2006
    ....
  18. ncbi request reprint Distinct nuclear and cytoplasmic functions of the S. pombe Cdc14-like phosphatase Clp1p/Flp1p and a role for nuclear shuttling in its regulation
    Susanne Trautmann
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical Center, Worcester, Massachusetts 01605, USA
    Curr Biol 15:1384-9. 2005
    ..Our results further suggest that the SIN does not keep Clp1p out of the nucleolus by regulating nucleolar affinity, as proposed for S. cerevisiae Cdc14p, but instead, Clp1p may be regulated by nuclear import/export...
  19. pmc The nucleolar Net1/Cfi1-related protein Dnt1 antagonizes the septation initiation network in fission yeast
    Quan Wen Jin
    Department of Molecular Genetics and Microbiology, and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Mol Biol Cell 18:2924-34. 2007
    ..Unlike Net1/Cfi1, which regulates the MEN through the Cdc14 phosphatase, Dnt1 can inhibit SIN signaling independently of Clp1, suggesting a novel connection between the nucleolus and the SIN pathway...
  20. pmc The SIN kinase Sid2 regulates cytoplasmic retention of the S. pombe Cdc14-like phosphatase Clp1
    Chun Ti Chen
    Department of Molecular Genetics and Microbiology and Interdisciplinary Graduate Program, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Biol 18:1594-9. 2008
    ..Because all components of this pathway are conserved, this might be a broadly conserved mechanism for regulation of Cdc14-family phosphatases...
  21. ncbi request reprint Mob2p interacts with the protein kinase Orb6p to promote coordination of cell polarity with cell cycle progression
    Ming Chin Hou
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Sci 116:125-35. 2003
    ..Our results suggest that Mob2p, along with Orb6p, is required for coordinating polarized cell growth during interphase with the onset of mitosis...
  22. pmc Initiation of cytokinesis is controlled through multiple modes of regulation of the Sid2p-Mob1p kinase complex
    Ming Chin Hou
    Department of Molecular Genetics and Microbiology and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Mol Cell Biol 24:3262-76. 2004
    ..Taken together, our results suggest that Sid2p kinase may utilize multiple modes of regulation including self-association, Mob1p binding, and phosphorylation to achieve its full activity at an appropriate time and place in the cell...
  23. pmc The mitosis-to-interphase transition is coordinated by cross talk between the SIN and MOR pathways in Schizosaccharomyces pombe
    Samriddha Ray
    Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Cell Biol 190:793-805. 2010
    ..Together, our results reveal a mutually antagonistic relationship between the SIN and MOR pathways, which is important for completion of cytokinesis and coordination of cytoskeletal remodeling at the mitosis-to-interphase transition...
  24. pmc A role for the septation initiation network in septum assembly revealed by genetic analysis of sid2-250 suppressors
    Quan Wen Jin
    Department of Molecular Genetics and Microbiology, and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester 01605, USA
    Genetics 172:2101-12. 2006
    ..Together these results suggest that the SIN has a role in promoting proper cell wall formation at the division septa...
  25. pmc A novel phosphatidylinositol(3,4,5)P3 pathway in fission yeast
    Prasenjit Mitra
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, 364 Plantation St, Rm 819, Worcester, MA 01605, USA
    J Cell Biol 166:205-11. 2004
    ..These studies suggest that a pathway for PI(3,4,5)P3 synthesis downstream of a class III phosphoinositide 3-kinase evolved before the appearance of class I phosphoinositide 3-kinases...
  26. ncbi request reprint Cytokinesis: myosin spots the ring
    Ming Chin Hou
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Curr Biol 12:R334-6. 2002
    ..Recent studies in fission yeast have shown that a myosin II-containing spot may be a novel progenitor structure essential for actomyosin ring assembly...
  27. pmc Scw1p antagonizes the septation initiation network to regulate septum formation and cell separation in the fission yeast Schizosaccharomyces pombe
    Quan Wen Jin
    Department of Molecular Genetics and Microbiology and Program in Cell Dynamics, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Eukaryot Cell 2:510-20. 2003
    ....
  28. ncbi request reprint Cell cycle: new functions for Cdc14 family phosphatases
    Susanne Trautmann
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical Center, 377 Plantation Street, Worcester, MA 01605, USA
    Curr Biol 12:R733-5. 2002
    ..Recent analyses in fission yeast, humans and now C. elegans suggest numerous other functions for this family of proteins...
  29. pmc Cytokinesis in eukaryotes
    David A Guertin
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Microbiol Mol Biol Rev 66:155-78. 2002
    ..In conclusion, we discuss how certain cells have utilized cytokinesis to direct development...
  30. ncbi request reprint The Clp1p/Flp1p phosphatase ensures completion of cytokinesis in response to minor perturbation of the cell division machinery in Schizosaccharomyces pombe
    Mithilesh Mishra
    Cell Division Laboratory, Temasek Life Sciences Laboratory, National University of Singapore, 1 Research Link, NUS, Singapore 117604, Rep of Singapore
    J Cell Sci 117:3897-910. 2004
    ..We conclude that the Clp1p/Flp1p-dependent cytokinesis checkpoint provides a previously unrecognized cell survival advantage when the cell division apparatus is mildly perturbed...
  31. ncbi request reprint First things first: spindle orientation and mitotic progression
    Dannel McCollum
    Nat Cell Biol 4:E225-6. 2002
  32. pmc The multiprotein exocyst complex is essential for cell separation in Schizosaccharomyces pombe
    Hongyan Wang
    The Institute of Molecular Agrobiology, The National University of Singapore, Singapore 117604, Republic of Singapore
    Mol Biol Cell 13:515-29. 2002
    ..We further propose that cell elongation and division septum assembly can continue with minimal levels of exocyst function...
  33. doi request reprint The role of Cdc14 phosphatases in the control of cell division
    Dawn M Clifford
    HHMI and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Biochem Soc Trans 36:436-8. 2008
    ..Here, we review the elucidated roles of Cdc14 phosphatases in cytokinesis and the current outstanding questions regarding their function in this process...

Research Grants21

  1. REGULATION OF CYTOKINESIS IN FISSION YEAST
    Dannel McCollum; Fiscal Year: 2007
    ....
  2. Regulation anf Function of Clp 1p Protein Phosphatase
    Dannel McCollum; Fiscal Year: 2006
    ..abstract_text> ..
  3. Regulation and function of the Clp 1p protein phosphatase
    Dannel McCollum; Fiscal Year: 2007
    ..3) To test a hypothesis that Clp1 promotes actomyosin ring stability through effects on Cdc15. 4) To determine how Clp1 and the anaphase promoting complex promote Cdc25 inactivation in late mitosis. ..
  4. Regulation and function of the Clp 1p protein phosphatase
    Dannel McCollum; Fiscal Year: 2010
    ..3) To test a hypothesis that Clp1 promotes actomyosin ring stability through effects on Cdc15. 4) To determine how Clp1 and the anaphase promoting complex promote Cdc25 inactivation in late mitosis. ..
  5. REGULATION OF CYTOKINESIS IN FISSION YEAST
    Dannel McCollum; Fiscal Year: 2006
    ..abstract_text> ..
  6. REGULATION OF CYTOKINESIS IN FISSION YEAST
    Dannel McCollum; Fiscal Year: 2010
    ....