Colleen McClung

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
    Olivier Berton
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Science 311:864-8. 2006
  2. pmc Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the ClockΔ19 mouse model of mania
    Laurent Coque
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Neuropsychopharmacology 36:1478-88. 2011
  3. ncbi Circadian rhythms, the mesolimbic dopaminergic circuit, and drug addiction
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    ScientificWorldJournal 7:194-202. 2007
  4. pmc Circadian genes, rhythms and the biology of mood disorders
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Pharmacol Ther 114:222-32. 2007
  5. ncbi The molecular mechanisms of morphine addiction
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas, Southwestern Medical Center, Dallas, TX, USA
    Rev Neurosci 17:393-402. 2006
  6. pmc Regulation of dopaminergic transmission and cocaine reward by the Clock gene
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 102:9377-81. 2005
  7. pmc Mania-like behavior induced by disruption of CLOCK
    Kole Roybal
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 104:6406-11. 2007
  8. pmc Orexin signaling mediates the antidepressant-like effect of calorie restriction
    Michael Lutter
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:3071-5. 2008
  9. ncbi Regulation of gene expression by chronic morphine and morphine withdrawal in the locus ceruleus and ventral tegmental area
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 25:6005-15. 2005
  10. pmc A role for the circadian genes in drug addiction
    Edgardo Falcon
    Department of Psychiatry, University of Texas, Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Neuropharmacology 56:91-6. 2009

Collaborators

Detail Information

Publications16

  1. ncbi Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
    Olivier Berton
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Science 311:864-8. 2006
    ..These results establish an essential role for BDNF in mediating long-term neural and behavioral plasticity in response to aversive social experiences...
  2. pmc Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the ClockΔ19 mouse model of mania
    Laurent Coque
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Neuropsychopharmacology 36:1478-88. 2011
    ....
  3. ncbi Circadian rhythms, the mesolimbic dopaminergic circuit, and drug addiction
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    ScientificWorldJournal 7:194-202. 2007
    ..This review highlights the association between circadian genes and drug addiction, and the possible role of the mesolimbic dopaminergic system in this association...
  4. pmc Circadian genes, rhythms and the biology of mood disorders
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Pharmacol Ther 114:222-32. 2007
    ..In this review, the evidence linking circadian rhythms and mood disorders, and what is known about the underlying biology of this association, is presented...
  5. ncbi The molecular mechanisms of morphine addiction
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas, Southwestern Medical Center, Dallas, TX, USA
    Rev Neurosci 17:393-402. 2006
    ....
  6. pmc Regulation of dopaminergic transmission and cocaine reward by the Clock gene
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 102:9377-81. 2005
    ..These findings demonstrate the involvement of a circadian-associated gene, Clock, in regulating dopamine function and cocaine reward...
  7. pmc Mania-like behavior induced by disruption of CLOCK
    Kole Roybal
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 104:6406-11. 2007
    ..These findings establish the Clock mutant mice as a previously unrecognized model of human mania and reveal an important role for CLOCK in the dopaminergic system in regulating behavior and mood...
  8. pmc Orexin signaling mediates the antidepressant-like effect of calorie restriction
    Michael Lutter
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:3071-5. 2008
    ..Together, these data indicate that orexin plays an essential role in mediating reduced depression-like symptoms induced by calorie restriction...
  9. ncbi Regulation of gene expression by chronic morphine and morphine withdrawal in the locus ceruleus and ventral tegmental area
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 25:6005-15. 2005
    ..Inhibition of either protein profoundly affects withdrawal responses, demonstrating that the genes identified in this study have important functional roles in mediating opiate-induced behaviors...
  10. pmc A role for the circadian genes in drug addiction
    Edgardo Falcon
    Department of Psychiatry, University of Texas, Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Neuropharmacology 56:91-6. 2009
    ..This review summarizes some of the basic research into the importance of circadian genes in drug addiction...
  11. ncbi Regulation of gene expression and cocaine reward by CREB and DeltaFosB
    Colleen A McClung
    The University of Texas Southwestern Medical Center, Department of Psychiatry and Center for Basic Neuroscience, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 6:1208-15. 2003
    ..These findings help define the molecular functions of CREB and DeltaFosB and identify clusters of genes that contribute to cocaine addiction...
  12. ncbi Neuroplasticity mediated by altered gene expression
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Neuropsychopharmacology 33:3-17. 2008
    ..This review summarizes some of the major transcriptional mechanisms that are thought to underlie neuronal and behavioral plasticity...
  13. ncbi DeltaFosB: a molecular switch for long-term adaptation in the brain
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Brain Res Mol Brain Res 132:146-54. 2004
    ....
  14. pmc CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits
    Deanna L Wallace
    Department of Psychiatry and Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 12:200-9. 2009
    ....
  15. ncbi Clock genes and bipolar disorder: implications for therapy
    Colleen A McClung
    Pharmacogenomics 8:1097-100. 2007
  16. ncbi Two functional but noncomplementing Drosophila tyrosine decarboxylase genes: distinct roles for neural tyramine and octopamine in female fertility
    Shannon H Cole
    Department of Biology, University of Virginia, Charlottesville, Virginia 22903, USA
    J Biol Chem 280:14948-55. 2005
    ..The egg retention phenotype of the dTdc2 mutant and the phenotypes associated with ectopic dTdc expression contribute to a model in which octopamine and tyramine have distinct and separable neural activities...

Research Grants8

  1. The Role of Circadian Genes in Drug Addiction
    Colleen McClung; Fiscal Year: 2007
    ..These studies will greatly enhance our understanding of the molecular changes that occur in the brain in response to drugs of abuse and how the circadian clock modulates drug addiction. ..
  2. Role of The Circadian Clock in the Development and Treatment of Mood Disorders
    Colleen A McClung; Fiscal Year: 2010
    ..These experiments could lead us to more targeted treatments for these devastating disorders in the future. ..
  3. Addiction-like behavior in models of mood disorders: role of CLOCK and NPAS2
    Colleen A McClung; Fiscal Year: 2010
    ..These studies will help us in developing potential treatments for addiction in the future. ..
  4. Role of The Circadian Clock in the Development and Treatment of Mood Disorders
    Colleen A McClung; Fiscal Year: 2011
    ..These experiments could lead us to more targeted treatments for these devastating disorders in the future. ..