Research Topics
Species | Colleen McClungSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the ClockΔ19 mouse model of maniaLaurent Coque
Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390 9070, USA
Neuropsychopharmacology 36:1478-88. 2011....
Circadian rhythms, the mesolimbic dopaminergic circuit, and drug addictionColleen A McClung
Department of Psychiatry and Center for Basic Neuroscience, The University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
ScientificWorldJournal 7:194-202. 2007..This review highlights the association between circadian genes and drug addiction, and the possible role of the mesolimbic dopaminergic system in this association...- Circadian genes, rhythms and the biology of mood disordersColleen A McClung
Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
Pharmacol Ther 114:222-32. 2007..In this review, the evidence linking circadian rhythms and mood disorders, and what is known about the underlying biology of this association, is presented... - The molecular mechanisms of morphine addictionColleen A McClung
Department of Psychiatry and Center for Basic Neuroscience, University of Texas, Southwestern Medical Center, Dallas, TX, USA
Rev Neurosci 17:393-402. 2006.... - Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stressOlivier Berton
Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
Science 311:864-8. 2006..These results establish an essential role for BDNF in mediating long-term neural and behavioral plasticity in response to aversive social experiences... - Regulation of dopaminergic transmission and cocaine reward by the Clock geneColleen A McClung
Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
Proc Natl Acad Sci U S A 102:9377-81. 2005..These findings demonstrate the involvement of a circadian-associated gene, Clock, in regulating dopamine function and cocaine reward... - Mania-like behavior induced by disruption of CLOCKKole Roybal
Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
Proc Natl Acad Sci U S A 104:6406-11. 2007..These findings establish the Clock mutant mice as a previously unrecognized model of human mania and reveal an important role for CLOCK in the dopaminergic system in regulating behavior and mood... - Orexin signaling mediates the antidepressant-like effect of calorie restrictionMichael Lutter
Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
J Neurosci 28:3071-5. 2008..Together, these data indicate that orexin plays an essential role in mediating reduced depression-like symptoms induced by calorie restriction... - Regulation of gene expression by chronic morphine and morphine withdrawal in the locus ceruleus and ventral tegmental areaColleen A McClung
Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070, USA
J Neurosci 25:6005-15. 2005..Inhibition of either protein profoundly affects withdrawal responses, demonstrating that the genes identified in this study have important functional roles in mediating opiate-induced behaviors... - A role for the circadian genes in drug addictionEdgardo Falcon
Department of Psychiatry, University of Texas, Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
Neuropharmacology 56:91-6. 2009..This review summarizes some of the basic research into the importance of circadian genes in drug addiction... - Regulation of gene expression and cocaine reward by CREB and DeltaFosBColleen A McClung
The University of Texas Southwestern Medical Center, Department of Psychiatry and Center for Basic Neuroscience, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9070, USA
Nat Neurosci 6:1208-15. 2003..These findings help define the molecular functions of CREB and DeltaFosB and identify clusters of genes that contribute to cocaine addiction... - Neuroplasticity mediated by altered gene expressionColleen A McClung
Department of Psychiatry and Center for Basic Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390 9070, USA
Neuropsychopharmacology 33:3-17. 2008..This review summarizes some of the major transcriptional mechanisms that are thought to underlie neuronal and behavioral plasticity... - DeltaFosB: a molecular switch for long-term adaptation in the brainColleen A McClung
Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9070, USA
Brain Res Mol Brain Res 132:146-54. 2004.... - CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficitsDeanna L Wallace
Department of Psychiatry and Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
Nat Neurosci 12:200-9. 2009.... - Clock genes and bipolar disorder: implications for therapyColleen A McClung
Pharmacogenomics 8:1097-100. 2007 - Two functional but noncomplementing Drosophila tyrosine decarboxylase genes: distinct roles for neural tyramine and octopamine in female fertilityShannon H Cole
Department of Biology, University of Virginia, Charlottesville, Virginia 22903, USA
J Biol Chem 280:14948-55. 2005..The egg retention phenotype of the dTdc2 mutant and the phenotypes associated with ectopic dTdc expression contribute to a model in which octopamine and tyramine have distinct and separable neural activities...
Research Grants
- The Role of Circadian Genes in Drug AddictionColleen McClung; Fiscal Year: 2007..These studies will greatly enhance our understanding of the molecular changes that occur in the brain in response to drugs of abuse and how the circadian clock modulates drug addiction. ..
- Role of The Circadian Clock in the Development and Treatment of Mood DisordersColleen A McClung; Fiscal Year: 2010..These experiments could lead us to more targeted treatments for these devastating disorders in the future. ..
- Addiction-like behavior in models of mood disorders: role of CLOCK and NPAS2Colleen A McClung; Fiscal Year: 2010..These studies will help us in developing potential treatments for addiction in the future. ..
- Role of The Circadian Clock in the Development and Treatment of Mood DisordersColleen A McClung; Fiscal Year: 2011..These experiments could lead us to more targeted treatments for these devastating disorders in the future. ..