Colleen A McClung

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Differential regulation of the period genes in striatal regions following cocaine exposure
    Edgardo Falcon
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 8:e66438. 2013
  2. pmc How might circadian rhythms control mood? Let me count the ways
    Colleen A McClung
    Department of Psychiatry and Translational Neuroscience Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA
    Biol Psychiatry 74:242-9. 2013
  3. pmc Circadian genes Period 1 and Period 2 in the nucleus accumbens regulate anxiety-related behavior
    Sade Spencer
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA
    Eur J Neurosci 37:242-50. 2013
  4. pmc Circadian rhythms and mood regulation: insights from pre-clinical models
    Colleen A McClung
    Department of Psychiatry, University of Pittsburgh Medical School, 450 Technology Dr Suite 223, Pittsburgh, PA 15219, United States
    Eur Neuropsychopharmacol 21:S683-93. 2011
  5. pmc Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the ClockΔ19 mouse model of mania
    Laurent Coque
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Neuropsychopharmacology 36:1478-88. 2011
  6. pmc Knockdown of Clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior
    Shibani Mukherjee
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Biol Psychiatry 68:503-11. 2010
  7. pmc Orexin signaling mediates the antidepressant-like effect of calorie restriction
    Michael Lutter
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:3071-5. 2008
  8. ncbi request reprint Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
    Olivier Berton
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Science 311:864-8. 2006
  9. pmc A mutation in CLOCK leads to altered dopamine receptor function
    Sade Spencer
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA
    J Neurochem 123:124-34. 2012
  10. pmc CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits
    Deanna L Wallace
    Department of Psychiatry and Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 12:200-9. 2009

Collaborators

Detail Information

Publications27

  1. pmc Differential regulation of the period genes in striatal regions following cocaine exposure
    Edgardo Falcon
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 8:e66438. 2013
    ..Taken together, these studies point to selective disruptions in Per gene rhythmicity in striatial regions following chronic cocaine treatment, which are mediated primarily by NPAS2...
  2. pmc How might circadian rhythms control mood? Let me count the ways
    Colleen A McClung
    Department of Psychiatry and Translational Neuroscience Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA
    Biol Psychiatry 74:242-9. 2013
    ..This review will summarize recent data that implicate the circadian system as a vital regulator of a variety of systems that are thought to play a role in the development of mood disorders. ..
  3. pmc Circadian genes Period 1 and Period 2 in the nucleus accumbens regulate anxiety-related behavior
    Sade Spencer
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA
    Eur J Neurosci 37:242-50. 2013
    ..Taken together, these results implicate the Per genes in the NAc in response to stress and the development of anxiety...
  4. pmc Circadian rhythms and mood regulation: insights from pre-clinical models
    Colleen A McClung
    Department of Psychiatry, University of Pittsburgh Medical School, 450 Technology Dr Suite 223, Pittsburgh, PA 15219, United States
    Eur Neuropsychopharmacol 21:S683-93. 2011
    ..This review will focus on the recent advances that have been gleaned from the use of pre-clinical models to further our understanding of how the circadian system regulates mood...
  5. pmc Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the ClockΔ19 mouse model of mania
    Laurent Coque
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Neuropsychopharmacology 36:1478-88. 2011
    ....
  6. pmc Knockdown of Clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior
    Shibani Mukherjee
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Biol Psychiatry 68:503-11. 2010
    ..Previously, we reported that mice with a mutation in the Clock gene (ClockDelta19) display a behavioral profile that is strikingly similar to bipolar patients in the manic state...
  7. pmc Orexin signaling mediates the antidepressant-like effect of calorie restriction
    Michael Lutter
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:3071-5. 2008
    ..Together, these data indicate that orexin plays an essential role in mediating reduced depression-like symptoms induced by calorie restriction...
  8. ncbi request reprint Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress
    Olivier Berton
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Science 311:864-8. 2006
    ..These results establish an essential role for BDNF in mediating long-term neural and behavioral plasticity in response to aversive social experiences...
  9. pmc A mutation in CLOCK leads to altered dopamine receptor function
    Sade Spencer
    Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA
    J Neurochem 123:124-34. 2012
    ..Taken together, these studies further elucidate the abnormalities in dopaminergic transmission that underlie mood, activity, and addictive behaviors...
  10. pmc CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits
    Deanna L Wallace
    Department of Psychiatry and Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 12:200-9. 2009
    ....
  11. pmc Mania-like behavior induced by disruption of CLOCK
    Kole Roybal
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 104:6406-11. 2007
    ..These findings establish the Clock mutant mice as a previously unrecognized model of human mania and reveal an important role for CLOCK in the dopaminergic system in regulating behavior and mood...
  12. pmc Lithium ameliorates nucleus accumbens phase-signaling dysfunction in a genetic mouse model of mania
    Kafui Dzirasa
    Department of Psychiatry, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 30:16314-23. 2010
    ....
  13. pmc Regulation of dopaminergic transmission and cocaine reward by the Clock gene
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Proc Natl Acad Sci U S A 102:9377-81. 2005
    ..These findings demonstrate the involvement of a circadian-associated gene, Clock, in regulating dopamine function and cocaine reward...
  14. pmc The role of clock in ethanol-related behaviors
    Angela Renee Ozburn
    Translational Neuroscience Program and Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Neuropsychopharmacology 38:2393-400. 2013
    ..Taken together, we have identified a significant role for Clock in the VTA as a negative regulator of ethanol intake and implicate the VTA dopamine system in this response. ..
  15. ncbi request reprint Regulation of gene expression by chronic morphine and morphine withdrawal in the locus ceruleus and ventral tegmental area
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 25:6005-15. 2005
    ..Inhibition of either protein profoundly affects withdrawal responses, demonstrating that the genes identified in this study have important functional roles in mediating opiate-induced behaviors...
  16. pmc Circadian genes, rhythms and the biology of mood disorders
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Pharmacol Ther 114:222-32. 2007
    ..In this review, the evidence linking circadian rhythms and mood disorders, and what is known about the underlying biology of this association, is presented...
  17. ncbi request reprint Circadian rhythms, the mesolimbic dopaminergic circuit, and drug addiction
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9070, USA
    ScientificWorldJournal 7:194-202. 2007
    ..This review highlights the association between circadian genes and drug addiction, and the possible role of the mesolimbic dopaminergic system in this association...
  18. ncbi request reprint Neuroplasticity mediated by altered gene expression
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, UT Southwestern Medical Center, Dallas, TX 75390 9070, USA
    Neuropsychopharmacology 33:3-17. 2008
    ..This review summarizes some of the major transcriptional mechanisms that are thought to underlie neuronal and behavioral plasticity...
  19. pmc Differential effects of chronic social stress and fluoxetine on meal patterns in mice
    Jaswinder Kumar
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Appetite 64:81-8. 2013
    ..Taken together, these results indicate that stress increases food intake by decreasing satiation, and that fluoxetine can reverse stress-induced changes in meal patterns...
  20. pmc A role for the circadian genes in drug addiction
    Edgardo Falcon
    Department of Psychiatry, University of Texas, Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Neuropharmacology 56:91-6. 2009
    ..This review summarizes some of the basic research into the importance of circadian genes in drug addiction...
  21. pmc Major depressive disorder: a loss of circadian synchrony?
    Nicole Edgar
    Department of Psychiatry and Translational Neuroscience Program, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Bioessays 35:940-4. 2013
    ..These findings will provide the foundation for future studies of gene-specific drug targets, and biomarkers for the disease. ..
  22. ncbi request reprint DeltaFosB: a molecular switch for long-term adaptation in the brain
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Brain Res Mol Brain Res 132:146-54. 2004
    ....
  23. pmc Cocaine self-administration behaviors in ClockΔ19 mice
    Angela Renee Ozburn
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, 450 Technology Dr BSPII Ste 233, Pittsburgh, PA 15219, USA
    Psychopharmacology (Berl) 223:169-77. 2012
    ....
  24. ncbi request reprint The molecular mechanisms of morphine addiction
    Colleen A McClung
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas, Southwestern Medical Center, Dallas, TX, USA
    Rev Neurosci 17:393-402. 2006
    ....
  25. ncbi request reprint Regulation of gene expression and cocaine reward by CREB and DeltaFosB
    Colleen A McClung
    The University of Texas Southwestern Medical Center, Department of Psychiatry and Center for Basic Neuroscience, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 6:1208-15. 2003
    ..These findings help define the molecular functions of CREB and DeltaFosB and identify clusters of genes that contribute to cocaine addiction...
  26. pmc An inhibitor of casein kinase 1 ε/δ partially normalizes the manic-like behaviors of the ClockΔ19 mouse
    Rachel Arey
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, USA
    Behav Pharmacol 23:392-6. 2012
    ..This drug had no significant effects on the behavior of wild-type mice at the doses tested. These results suggest that CK1ε/δ inhibitors could be viable drugs for the treatment of bipolar disorder...