Research Topics
| RAYMOND SCOTT MCCLELLANDSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Detail Information
Publications
Vaginal washing and increased risk of HIV-1 acquisition among African women: a 10-year prospective studyR Scott McClelland
Department of Medicine, University of Washington, Seattle, WA 98104, USA
AIDS 20:269-73. 2006..No prospective study has examined the risk of HIV-1 acquisition associated with vaginal washing, although intravaginal practices have been identified as potentially important contributors to HIV-1 susceptibility...- HIV-1 acquisition and disease progression are associated with decreased high-risk sexual behaviour among Kenyan female sex workersR Scott McClelland
Departments of Medicine, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA
AIDS 20:1969-73. 2006..Changes in sexual risk behaviour may occur following HIV-1 infection... 
Improvement of vaginal health for Kenyan women at risk for acquisition of human immunodeficiency virus type 1: results of a randomized trialR Scott McClelland
Department of Medicine, University of Washington, Seattle, USA
J Infect Dis 197:1361-8. 2008..Vaginal infections are common and have been associated with increased risk for acquisition of human immunodeficiency virus type 1 (HIV-1)...- A comparison of genital HIV-1 shedding and sexual risk behavior among Kenyan women based on eligibility for initiation of HAART according to WHO guidelinesR Scott McClelland
Departments of Medicine, University of Washington, Box 359909, 325 Ninth Avenue, Seattle, WA 98104, USA
J Acquir Immune Defic Syndr 41:611-5. 2006..Guidelines for initiating antiretrovirals are based on markers of advanced disease and are not directly linked to markers of HIV-1 transmission such as viral shedding... 
Treatment with antiretroviral therapy is not associated with increased sexual risk behavior in Kenyan female sex workersR Scott McClelland
Department of Medicine, University of Washington, Seattle, USA
AIDS 24:891-7. 2010..The objective of this study was to test the hypothesis that sexual risk behavior would increase following initiation of antiretroviral therapy (ART) in Kenyan female sex workers (FSWs)...- Infection with Trichomonas vaginalis increases the risk of HIV-1 acquisitionR Scott McClelland
Department of Medicine, University of Washington, Seattle, WA 98104, USA
J Infect Dis 195:698-702. 2007..52-fold (95% confidence interval, 1.04-2.24-fold) increased risk of HIV-1 acquisition after adjustment for potential confounding factors. Treatment and prevention of T. vaginalis infection could reduce HIV-1 risk in women... - Prospective study of vaginal bacterial flora and other risk factors for vulvovaginal candidiasisR Scott McClelland
Department of Medicine, University of Washington, Seattle, WA 98104, USA
J Infect Dis 199:1883-90. 2009..Our objective was to determine the relationship between vaginal bacterial flora and VVC... - Contribution of HIV-1 infection to acquisition of sexually transmitted disease: a 10-year prospective studyR Scott McClelland
Department of Medicine, University of Washington, Seattle, Washington 98104, USA
J Infect Dis 191:333-8. 2005..Sexually transmitted diseases (STDs) enhance human immunodeficiency virus (HIV)-1 susceptibility, but few studies have examined the reciprocal effect of HIV-1 on STD acquisition... - Micronutrient supplementation increases genital tract shedding of HIV-1 in women: results of a randomized trialR Scott McClelland
Department of Medicine, University of Washington, Seattle, WA 98104, USA
J Acquir Immune Defic Syndr 37:1657-63. 2004..The potential benefit of micronutrient supplementation in HIV-1-seropositive women should be considered in relation to the potential for increased infectivity... - A prospective study of hormonal contraceptive use and cervical shedding of herpes simplex virus in human immunodeficiency virus type 1-seropositive womenR Scott McClelland
Departments of Medicine, International AIDS Research and Training Program, University of Washington, Box 359909, 325 Ninth Avenue, Seattle, WA 98104, USA
J Infect Dis 185:1822-5. 2002..In this prospective study, use of hormonal contraceptives did not increase detection of cervical HSV... - Association between cervical shedding of herpes simplex virus and HIV-1R Scott McClelland
International AIDS Research and Training Program, Department of Medicine, University of Washington, Box 359909, 325 9th Avenue, Seattle, WA 98104, USA
AIDS 16:2425-30. 2002..To investigate the association between the cervical shedding of herpes simplex virus (HSV) and HIV-1... - Vitamin A supplementation and genital shedding of herpes simplex virus among HIV-1-infected women: a randomized clinical trialJared M Baeten
Department of Epidemiology, University of Washington, Seattle, Washington 98104 2499, USA
J Infect Dis 189:1466-71. 2004..Vitamin A supplementation is unlikely to decrease HSV shedding and infectivity... - Hormonal contraception and risk of cervical infections among HIV-1-seropositive Kenyan womenLudo Lavreys
Departments of Epidemiology and Medicine, University of Washington, Seattle 98104 2499, USA
AIDS 18:2179-84. 2004..To evaluate the relationship between hormonal contraceptive use and the acquisition of cervical sexually transmitted infections (STI) among HIV-1-infected women... - Quantification of genital human immunodeficiency virus type 1 (HIV-1) DNA in specimens from women with low plasma HIV-1 RNA levels typical of HIV-1 nontransmittersSarah Benki
Department of Microbiology, University of Washington, Seattle, WA 98109, USA, and Coast Provincial General Hospital, Mombasa, Kenya
J Clin Microbiol 44:4357-62. 2006..The assay described here can be utilized in future efforts to examine the role of cell-associated HIV-1 in transmission... - Breadth of neutralizing antibody response to human immunodeficiency virus type 1 is affected by factors early in infection but does not influence disease progressionAnne Piantadosi
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
J Virol 83:10269-74. 2009..Thus, a broad NAb response results from a high level of antigenic stimulation early in infection, which likely accounts for prior observations that greater NAb response breadth is associated with a higher viral load later in infection... - HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loadsJared M Baeten
Department of Medicine, University of Washington, Seattle, WA, USA
J Infect Dis 195:1177-80. 2007..There were no differences in plasma viral load by HIV-1 subtype during follow-up. HIV-1 subtype D infection is associated with a >2-fold higher risk of death than subtype A infection, in spite of similar plasma HIV-1 loads... - Reducing HIV-1 transmission through prevention strategies targeting HIV-1-seropositive individualsR Scott McClelland
Department of Medicine, University of Washington, Seattle, WA, USA
J Antimicrob Chemother 57:163-6. 2006..Further work is urgently needed to develop, test and implement comprehensive strategies for prevention in positives... - The effect of hormonal contraception on genital tract shedding of HIV-1Chia C Wang
Department of Medicine, University of Washington, Seattle, Washington 98104-2499, USA
AIDS 18:205-9. 2004..Our results may have important implications regarding the infectivity of women using hormonal contraception, and highlight the need for epidemiologic studies of transmission rates from women using and not using hormonal contraception... - Effect of exogenous hormonesR Scott McClelland
University of Washington, Seattle, WA, USA
J Acquir Immune Defic Syndr 38:S38-9. 2005 - A decrease in albumin in early HIV type 1 infection predicts subsequent disease progressionSusan M Graham
Department of Medicine, University of Washington, Seattle, Washington 98104, USA
AIDS Res Hum Retroviruses 23:1197-200. 2007..0, p = 0.008). Trends for an increased risk of mortality were also seen. A greater decrease in albumin levels accompanying HIV-1 acquisition may be a marker for changes in early infection associated with more rapid disease progression... - A prospective study of risk factors for bacterial vaginosis in HIV-1-seronegative African womenR Scott McClelland
Department of Medicine, University of Washington, Seattle, WA 98104, USA
Sex Transm Dis 35:617-23. 2008..Bacterial vaginosis (BV) is common and has been associated with increased HIV-1 susceptibility. The objective of this study was to identify risk factors for BV in African women at high risk for acquiring HIV-1... - Increased risk of genital ulcer disease in women during the first month after initiating antiretroviral therapySusan M Graham
Departments of Medicine, Epidemiology and Global Health, University of Washington, Seattle, WA 98104 2499, USA
J Acquir Immune Defic Syndr 52:600-3. 2009..To better define this risk, we monitored 134 women at ART initiation and monthly thereafter... - Vitamin A supplementation and human immunodeficiency virus type 1 shedding in women: results of a randomized clinical trialJared M Baeten
Department of Epidemiology, University of Washington, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
J Infect Dis 185:1187-91. 2002..Vitamin A supplementation is unlikely to decrease the infectivity of women infected with HIV-1... - Antiretroviral adherence and development of drug resistance are the strongest predictors of genital HIV-1 shedding among women initiating treatmentSusan M Graham
University of Washington, Seattle, Washington 98104 2499, USA
J Infect Dis 202:1538-42. 2010..04). These results emphasize the importance of adherence to optimize the potential benefits of ART for reducing HIV-1 transmission risk... - Genital ulceration does not increase HIV-1 shedding in cervical or vaginal secretions of women taking antiretroviral therapySusan M Graham
University of Washington, Box 359909, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
Sex Transm Infect 87:114-7. 2011..The effect of GUD on HIV-1 shedding among ART-treated women is not known. The objective of this study was to test the hypothesis that genital ulcerations increase genital HIV-1-RNA shedding in women receiving ART... - Post-prostatic massage fluid/urine as an alternative to semen for studying male genitourinary HIV-1 sheddingSusan M Graham
University of Washington, Box 359909, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
Sex Transm Infect 87:232-7. 2011..Because semen collection is often impractical, the acceptability, feasibility and validity of post-prostatic massage fluid/urine (post-PMF/U) was evaluated for studying male genitourinary HIV-1 shedding... - Hormonal contraceptive use, herpes simplex virus infection, and risk of HIV-1 acquisition among Kenyan womenJared M Baeten
Seattle HIV Prevention Trials Unit, Department of Medicine, University of Washington, 9012 Boren Avenue, Seattle, WA 98104, USA
AIDS 21:1771-7. 2007..A recent study from Uganda and Zimbabwe found that women using hormonal contraception were at increased risk for HIV-1 if they were seronegative for herpes simplex virus type 2 (HSV-2), but not if they were HSV-2 seropositive... 
Higher pre-infection vitamin E levels are associated with higher mortality in HIV-1-infected Kenyan women: a prospective studySusan M Graham
Department of Medicine, University of Washington, Seattle, Washington 98195, USA
BMC Infect Dis 7:63. 2007..However, vitamin E supplementation has also been reported to increase CCR5 expression, which could increase HIV-1 replication. We hypothesized that vitamin E levels at HIV-1 acquisition may influence disease progression...- Vitamin A deficiency and the acute phase response among HIV-1-infected and -uninfected women in KenyaJared M Baeten
Department of Epidemiology, University of Washington, Seattle 98104 2499, USA
J Acquir Immune Defic Syndr 31:243-9. 2002..These results provide possible explanations for the disparity between observational studies and randomized trials of vitamin A for HIV-1 infection... - Use of serum retinol-binding protein for prediction of vitamin A deficiency: effects of HIV-1 infection, protein malnutrition, and the acute phase responseJared M Baeten
Department of Epidemiology, University of Washington, Seattle, WA 98104, USA
Am J Clin Nutr 79:218-25. 2004..The performance of RBP in the context of infection or protein malnutrition, however, has not been evaluated... - Higher set point plasma viral load and more-severe acute HIV type 1 (HIV-1) illness predict mortality among high-risk HIV-1-infected African womenLudo Lavreys
Department of Epidemiology, Medicine, and Biostatistics, University of Washington, Seattle, WA 98104 2499, USA
Clin Infect Dis 42:1333-9. 2006..We used data from a prospective cohort study of female sex workers in Mombasa, Kenya, who were followed up monthly from before the date of HIV-1 infection... - HIV-1 infection alters the retinol-binding protein:transthyretin ratio even in the absence of the acute phase responseJared M Baeten
Department of Epidemiology, University of Washington, Seattle, WA, USA
J Nutr 136:1624-9. 2006..Our results raise questions about the utility of this measurement given the high prevalence of HIV-1 infection in areas where vitamin A deficiency is common... - Low serum albumin and the acute phase response predict low serum selenium in HIV-1 infected womenPaul K Drain
Department of Medicine, University of Washington, 1959 NE Pacific, A 300 Health Sciences, Box 356340, Seattle, WA 98105, USA
BMC Infect Dis 6:85. 2006..Low serum selenium has been associated with lower CD4 counts and greater mortality among HIV-1-seropositive individuals, but most studies have not controlled for serum albumin and the presence of an acute phase response... - Associations between intravaginal practices and bacterial vaginosis in Kenyan female sex workers without symptoms of vaginal infectionsWisal M Hassan
Department of Epidemiology, University of Washington, Seattle, Washington, USA
Sex Transm Dis 34:384-8. 2007..Bacterial vaginosis (BV) is highly prevalent among African women and has been associated with adverse pregnancy outcomes, sexually transmitted diseases, and HIV-1... - High levels of cervical HIV-1 RNA during early HIV-1 infectionLudo Lavreys
Department of Epidemiology, University of Washington, Seattle, Washington, USA
AIDS 20:2389-90. 2006..43 versus 2.85 log10 copies/swab, P < 0.001). After adjusting for HIV-1-plasma RNA, cervical HIV-1 RNA from 30 days or less after infection was increased by 0.45 log10 copies/swab (P = 0.006)... - Initiation of antiretroviral therapy leads to a rapid decline in cervical and vaginal HIV-1 sheddingSusan M Graham
Department of Medicine, University of Washington, Seattle, Washington, USA
AIDS 21:501-7. 2007..Antiretroviral therapy (ART) may decrease HIV-1 infectivity in women by reducing genital HIV-1 shedding... - Relationship between markers of HIV-1 disease progression and serum beta-carotene concentrations in Kenyan womenJared M Baeten
Department of Medicine, University of Washington, Seattle, WA 98104, USA
Int J STD AIDS 18:202-6. 2007.... - Prevalence and correlates of genital warts in Kenyan female sex workersBarbara E Kavanaugh
University of Washington, Seattle, WA, USA
Sex Transm Dis 39:902-5. 2012..Because of the high prevalence of human immunodeficiency virus type 1 (HIV-1) in this population, we were particularly interested in the association between HIV-1 infection and genital warts... - Analysis of the percentage of human immunodeficiency virus type 1 sequences that are hypermutated and markers of disease progression in a longitudinal cohort, including one individual with a partially defective VifAnne Piantadosi
Fred Hutchinson Cancer Center, Seattle, WA 98109 1024, USA
J Virol 83:7805-14. 2009.... - Risk factors for human immunodeficiency virus type-1 acquisition in women in AfricaSarah Benki
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
J Neurovirol 11:58-65. 2005..In addition, they are a potential source of transmission to their infants. A better understanding of the factors that influence HIV-1 susceptibility is key to developing interventions to control the epidemic...
Research Grants
- Antiretroviral Therapy and HIV-1 Infectivity in WomenRaymond McClelland; Fiscal Year: 2009....
- Antiretroviral Therapy and HIV-1 Infectivity in WomenRAYMOND SCOTT MCCLELLAND; Fiscal Year: 2010....