CRAIG J contact MCCLAIN

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. pmc Polychlorinated biphenyls, lead, and mercury are associated with liver disease in American adults: NHANES 2003-2004
    Matt Cave
    Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, Kentucky 40202, USA
    Environ Health Perspect 118:1735-42. 2010
  2. ncbi request reprint Probiotics in the treatment of the liver diseases
    Irina A Kirpich
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville, KY 40202, USA
    J Am Coll Nutr 31:14-23. 2012
  3. doi request reprint Zinc and liver disease
    Mohammad K Mohammad
    University of Louisville, Louisville, KY, USA
    Nutr Clin Pract 27:8-20. 2012
  4. ncbi request reprint Chronic ethanol-mediated decrease in cAMP primes macrophages to enhanced LPS-inducible NF-kappaB activity and TNF expression: relevance to alcoholic liver disease
    Leila Gobejishvili
    Dept of Medicine, Pharmacology and Toxicology, Univ of Louisville Medical Center, 550 S Jackson St, ACB 3rd Floor, Louisville, KY 40292, USA
    Am J Physiol Gastrointest Liver Physiol 291:G681-8. 2006
  5. ncbi request reprint Recent advances in alcoholic liver disease. IV. Dysregulated cytokine metabolism in alcoholic liver disease
    Craig J McClain
    Department of Internal Medicine, University of Louisville Medical Center, Louisville, Kentucky 40292, USA
    Am J Physiol Gastrointest Liver Physiol 287:G497-502. 2004
  6. ncbi request reprint Clinical implications of oxidative stress and antioxidant therapy
    Gerald W Dryden
    Department of Internal Medicine, University of Louisville Medical Center, 550 S Jackson Street, ACB 3rd Floor, Louisville, KY 40292, USA
    Curr Gastroenterol Rep 7:308-16. 2005
  7. ncbi request reprint Mechanisms of non-alcoholic steatohepatitis
    Craig J McClain
    Department of Internal Medicine, University of Louisville Medical Center, 530 South Jackson Street, ACB 3rd Floor, Louisville, KY 40292, USA
    Alcohol 34:67-79. 2004
  8. ncbi request reprint Monocyte activation in alcoholic liver disease
    Craig J McClain
    Department of Medicine, University of Louisville Medical Center and the Veterans Administration, Louisville, KY 40292, USA
    Alcohol 27:53-61. 2002
  9. ncbi request reprint Dysregulated cytokine metabolism, altered hepatic methionine metabolism and proteasome dysfunction in alcoholic liver disease
    Craig McClain
    Department of Internal Medicine, Department of Pharmacology and Toxicology, University of Louisville Medical Center, Louisville, KY 40202, USA
    Alcohol Clin Exp Res 29:180S-8S. 2005
  10. ncbi request reprint S-Adenosylmethionine, cytokines, and alcoholic liver disease
    Craig J McClain
    Department of Medicine, University of Louisville Medical Center, KY 40292, USA
    Alcohol 27:185-92. 2002

Collaborators

Detail Information

Publications71

  1. pmc Polychlorinated biphenyls, lead, and mercury are associated with liver disease in American adults: NHANES 2003-2004
    Matt Cave
    Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Louisville, Louisville, Kentucky 40202, USA
    Environ Health Perspect 118:1735-42. 2010
    ..However, the potential role of low-level environmental pollution on liver disease in the general population has not been evaluated...
  2. ncbi request reprint Probiotics in the treatment of the liver diseases
    Irina A Kirpich
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Louisville, KY 40202, USA
    J Am Coll Nutr 31:14-23. 2012
    ..The present review summarizes the recent studies highlighting the role of the intestinal microflora in the development of NAFLD and ALD and the potential efficacy of probiotics as a therapeutic strategy for liver diseases...
  3. doi request reprint Zinc and liver disease
    Mohammad K Mohammad
    University of Louisville, Louisville, KY, USA
    Nutr Clin Pract 27:8-20. 2012
    ..The dose of zinc used for treatment of liver disease is usually 50 mg of elemental zinc taken with a meal to decrease the potential side effect of nausea...
  4. ncbi request reprint Chronic ethanol-mediated decrease in cAMP primes macrophages to enhanced LPS-inducible NF-kappaB activity and TNF expression: relevance to alcoholic liver disease
    Leila Gobejishvili
    Dept of Medicine, Pharmacology and Toxicology, Univ of Louisville Medical Center, 550 S Jackson St, ACB 3rd Floor, Louisville, KY 40292, USA
    Am J Physiol Gastrointest Liver Physiol 291:G681-8. 2006
    ..Furthermore, these data also support the notion that cAMP-elevating agents could constitute an effective therapeutic approach in attenuating or preventing the progression of liver disease in alcoholic patients...
  5. ncbi request reprint Recent advances in alcoholic liver disease. IV. Dysregulated cytokine metabolism in alcoholic liver disease
    Craig J McClain
    Department of Internal Medicine, University of Louisville Medical Center, Louisville, Kentucky 40292, USA
    Am J Physiol Gastrointest Liver Physiol 287:G497-502. 2004
    ..Cytokines, such as transforming growth factor-beta, play a critical role in the fibrosis of ALD. Multiple new strategies are under investigation to modulate cytokine metabolism as a form of therapy for ALD...
  6. ncbi request reprint Clinical implications of oxidative stress and antioxidant therapy
    Gerald W Dryden
    Department of Internal Medicine, University of Louisville Medical Center, 550 S Jackson Street, ACB 3rd Floor, Louisville, KY 40292, USA
    Curr Gastroenterol Rep 7:308-16. 2005
    ..Antioxidant supplementation has been used with some success in the treatment of chronic pancreatitis. This review covers recent findings related to oxidative stress in liver disease, inflammatory bowel disease, and pancreatitis...
  7. ncbi request reprint Mechanisms of non-alcoholic steatohepatitis
    Craig J McClain
    Department of Internal Medicine, University of Louisville Medical Center, 530 South Jackson Street, ACB 3rd Floor, Louisville, KY 40292, USA
    Alcohol 34:67-79. 2004
    ....
  8. ncbi request reprint Monocyte activation in alcoholic liver disease
    Craig J McClain
    Department of Medicine, University of Louisville Medical Center and the Veterans Administration, Louisville, KY 40292, USA
    Alcohol 27:53-61. 2002
    ..We postulate that activation of monocytes and macrophages with subsequent proinflammatory cytokine production plays an important role in certain metabolic complications of ALD and is a component of the liver injury of ALD...
  9. ncbi request reprint Dysregulated cytokine metabolism, altered hepatic methionine metabolism and proteasome dysfunction in alcoholic liver disease
    Craig McClain
    Department of Internal Medicine, Department of Pharmacology and Toxicology, University of Louisville Medical Center, Louisville, KY 40202, USA
    Alcohol Clin Exp Res 29:180S-8S. 2005
    ..This article reviews the interactions of cytokines, altered methionine metabolism, and proteasome dysfunction in the development of ALD...
  10. ncbi request reprint S-Adenosylmethionine, cytokines, and alcoholic liver disease
    Craig J McClain
    Department of Medicine, University of Louisville Medical Center, KY 40292, USA
    Alcohol 27:185-92. 2002
    ....
  11. ncbi request reprint Trace metals and the elderly
    Craig J McClain
    Department of Internal Medicine, University of Louisville Medical Center, 550 S Jackson Street, ACB 3rd Floor, Louisville, KY 40292, USA
    Clin Geriatr Med 18:801-18, vii-viii. 2002
    ....
  12. pmc Zinc supplementation reverses alcohol-induced steatosis in mice through reactivating hepatocyte nuclear factor-4alpha and peroxisome proliferator-activated receptor-alpha
    Xinqin Kang
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Hepatology 50:1241-50. 2009
    ..Consequently, zinc deprivation caused cellular accumulation of lipid droplets, triglycerides and free fatty acids in the HepG2 cells...
  13. ncbi request reprint Efficacy of a transforming growth factor beta 2 containing nutritional support formula in a murine model of inflammatory bowel disease
    Helieh S Oz
    Department of Medicine, Section of Gastroenterology Nutrition, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Am Coll Nutr 23:220-6. 2004
    ..The objective of this study was to determine whether a diet containing TGF-beta 2 modulates intestinal injury and immune responses in an Interleukin-10 knockout (IL-10-/-) mouse model of IBD...
  14. ncbi request reprint S-adenosylhomocysteine sensitizes to TNF-alpha hepatotoxicity in mice and liver cells: a possible etiological factor in alcoholic liver disease
    Zhenyuan Song
    Department of Medicine, University of Louisville College of Medicine, Louisville, KY, USA
    Hepatology 40:989-97. 2004
    ..These data further support improving the S-adenosylmethionine-to-SAH ratio and removal of intracellular SAH as potential therapeutic options in alcoholic liver disease...
  15. pmc Preservation of intestinal structural integrity by zinc is independent of metallothionein in alcohol-intoxicated mice
    Jason C Lambert
    Department of Pharmacology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Am J Pathol 164:1959-66. 2004
    ..These results thus demonstrate that zinc preservation of intestinal structural integrity is associated with suppression of endotoxemia and liver injury induced by acute exposure to ethanol and the zinc protection is independent of MT...
  16. doi request reprint Tetrathiomolybdate protects against bile duct ligation-induced cholestatic liver injury and fibrosis
    Ming Song
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Louisville School of Medicine, 550 S Jackson St, Louisville, KY 40202, USA
    J Pharmacol Exp Ther 325:409-16. 2008
    ..The protective mechanism seems to be independent of oxidative stress. Our data provide further evidence that TM might be a potential therapy for hepatic fibrosis...
  17. ncbi request reprint Inhibition of proteasome function leads to NF-kappaB-independent IL-8 expression in human hepatocytes
    Swati Joshi-Barve
    Department of Internal Medicine, University of Louisville Medical Center, Louisville, KY 40292, USA
    Hepatology 38:1178-87. 2003
    ..In conclusion, hepatocytes dying because of inhibition of proteasome function produce massive quantities of the proinflammatory chemokine IL-8, possibly resulting in neutrophil infiltration, increased inflammation, and liver injury...
  18. ncbi request reprint Metallothionein overexpression does not protect against inflammatory bowel disease in a murine colitis model
    Helieh S Oz
    Department of Medicine, Division of Digestive Diseases and Nutrition, University of Kentucky Medical Center, Lexington, KY 40536, USA
    Med Sci Monit 11:BR69-73. 2005
    ..We evaluated whether modulation of metallothionein (MT, and subsequent oxidative stress) would influence the development and progression of colitis...
  19. pmc Zinc supplementation enhances hepatic regeneration by preserving hepatocyte nuclear factor-4alpha in mice subjected to long-term ethanol administration
    Xinqin Kang
    Department of Medicine, University of Louisville School of Medicine, 511 South Floyd Street, Louisville, KY 40292, USA
    Am J Pathol 172:916-25. 2008
    ....
  20. ncbi request reprint Advances in alcoholic liver disease
    Zhenyuan Song
    Department of Internal Medicine, University of Louisville Medical Center, 550 South Jackson Street, ACB 3rd Floor, Louisville, KY 40292, USA
    Curr Gastroenterol Rep 6:71-6. 2004
    ....
  21. ncbi request reprint Albumin therapy in clinical practice
    Christian M Mendez
    Department of Internal Medicine, University of Louisville Medical Center, Louisville, KY 40292, USA
    Nutr Clin Pract 20:314-20. 2005
    ..This article will provide an overview of albumin metabolism, use of albumin for volume expansion, the potential therapeutic role of albumin in liver disease, and the role of albumin therapy in nutrition...
  22. pmc Glutathione-enhancing agents protect against steatohepatitis in a dietary model
    Helieh S Oz
    Department of Internal Medicine, Digestive Diseases and Nutrition, University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Biochem Mol Toxicol 20:39-47. 2006
    ..Rats fed (ad libitum) amino acid based methionine-choline deficient (MCD) diet were further gavaged with (1) vehicle (MCD), (2) S-adenosylmethionine (SAMe), or (3) 2(RS)-n-propylthiazolidine-4(R)-carboxylic acid (PTCA)...
  23. ncbi request reprint Decreased serum adiponectin: an early event in pediatric nonalcoholic fatty liver disease
    Miriam Vos Louthan
    Division of Gastroenterology and the Department of Pediatrics, University of Louisville, University of Louisville Medical Center, Louisville, KY 40202, USA
    J Pediatr 147:835-8. 2005
    ..To evaluate the relative concentrations of cytokines in pediatric nonalcoholic fatty liver disease (NAFLD)...
  24. ncbi request reprint Decreased prevalence of nonalcoholic fatty liver disease in black obese children
    Miriam V Louthan
    Department of Pediatrics, Division of Gastroenterology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Pediatr Gastroenterol Nutr 41:426-9. 2005
    ..We propose that abnormal alanine aminotransferase (ALT) is more common in whites than blacks, males than females, and children over 12 compared with younger children in a prospective study...
  25. ncbi request reprint Preservation of hepatocyte nuclear factor-4alpha is associated with zinc protection against TNF-alpha hepatotoxicity in mice
    Zhanxiang Zhou
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA
    Exp Biol Med (Maywood) 232:622-8. 2007
    ..These results suggest that zinc protects against TNF-alpha hepatotoxicity, at least partially, through preservation of the zinc finger protein HNF-4alpha...
  26. pmc Mechanisms and cell signaling in alcoholic liver disease
    Juliane I Beier
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Biol Chem 391:1249-64. 2010
    ..The purpose of this review is to summarize the established and proposed mechanisms by which chronic alcohol abuse damages the liver and to highlight key signaling events known or hypothesized to mediate these effects...
  27. doi request reprint Obesity-induced hepatic hypoperfusion primes for hepatic dysfunction after resuscitated hemorrhagic shock
    Paul J Matheson
    Department of Surgery, University of Louisville, Louisville, KY 40292, USA
    Surgery 146:739-47; discussion 747-8. 2009
    ..We hypothesized that obesity further aggravates liver dysfunction by reduced hepatic perfusion following resuscitated hemorrhagic shock (HEM)...
  28. pmc Genome-wide transcriptome expression in the liver of a mouse model of high carbohydrate diet-induced liver steatosis and its significance for the disease
    Ion V Deaciuc
    Division of Gastroenterology Hepatology, Department of Medicine, University of Louisville School of Medicine, 550 S Jackson Street, ACB Bldg, Third Floor, Louisville, KY, 40202, USA
    Hepatol Int 2:39-49. 2008
    ..To perform a large-scale gene profiling of the liver in a mouse model of fatty liver induced by high carbohydrate (sucrose) diet (HCD) to gain a deeper insight into potential mechanisms of diet-induced hepatic steatosis...
  29. doi request reprint Zinc supplementation inhibits hepatic apoptosis in mice subjected to a long-term ethanol exposure
    Zhanxiang Zhou
    The University of Louisville School of Medicine, Department of Medicine, 511 South Floyd Street, MDR Room 529, Louisville, KY 40292, USA
    Exp Biol Med (Maywood) 233:540-8. 2008
    ..In conclusion, zinc supplementation prevented hepatocyte apoptosis in mice subjected to long-term ethanol exposure, and the action of zinc is likely through suppression of oxidative stress and death receptor-mediated pathways...
  30. doi request reprint Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver disease
    Zhenyuan Song
    Department of Medicine, University of Louisville, Louisville, KY, USA
    Hepatology 47:867-79. 2008
    ....
  31. ncbi request reprint Silymarin prevents palmitate-induced lipotoxicity in HepG2 cells: involvement of maintenance of Akt kinase activation
    Zhenyuan Song
    Division of Gastroenterology Hepatology, Department of Internal Medicine, University of Louisville School of Medicine, 511 S Floyd Street, Louisville, KY 40202, USA
    Basic Clin Pharmacol Toxicol 101:262-8. 2007
    ..These data also provide a further rationale for exploration of the use of silymarin in the treatment of non-alcoholic steatohepatitis...
  32. ncbi request reprint Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis
    Zhenyuan Song
    Dept of Medicine, Univ of Louisville Medical Center, Louisville, KY 40292, USA
    Am J Physiol Gastrointest Liver Physiol 293:G894-902. 2007
    ..Our findings are the first to suggest that betaine might serve as a therapeutic tool to attenuate hepatic steatosis by targeting the hepatic AMPK system...
  33. ncbi request reprint Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes
    Swati Joshi-Barve
    Department of Internal Medicine, the University of Louisville Medical Center, Louisville, KY 40292, USA
    Hepatology 46:823-30. 2007
    ....
  34. pmc Alcohol-induced S-adenosylhomocysteine accumulation in the liver sensitizes to TNF hepatotoxicity: possible involvement of mitochondrial S-adenosylmethionine transport
    Zhenyuan Song
    Department of Medicine, University of Louisville Medical Center, Louisville, KY 40292, United States
    Biochem Pharmacol 74:521-31. 2007
    ..In conclusion, our results demonstrate that depletion of the mitochondrial SAM pool by SAH, which is elevated during chronic alcohol consumption, plays a critical role in SAH induced sensitization to TNF hepatotoxicity...
  35. ncbi request reprint Diabetes enhances lipopolysaccharide-induced cardiac toxicity in the mouse model
    Ye Song
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY, USA
    Cardiovasc Toxicol 3:363-72. 2003
    ..These results suggest that diabetes significantly enhances endotoxin-induced cardiac toxicity, possibly through mechanisms that involve inflammatory/acute-phase cytokines...
  36. pmc A critical involvement of oxidative stress in acute alcohol-induced hepatic TNF-alpha production
    Zhanxiang Zhou
    Department of Medicine, University of Louisville School of Medicine, 511 South Floyd Street, MDR 525, Louisville, KY, USA
    Am J Pathol 163:1137-46. 2003
    ....
  37. ncbi request reprint Mechanisms of alcohol-mediated CD4+ T lymphocyte death: relevance to HIV and HCV pathogenesis
    Shirish S Barve
    Department of Medicine, University of Louisville Medical Center, KY 40202, USA
    Front Biosci 7:d1689-96. 2002
    ..Work done by us, and others, on the effects of ethanol on CD4+ T cell function and survival strongly suggests that alcohol plays a significant role as a co-factor in HIV and/or HCV pathogenesis...
  38. ncbi request reprint Alcohol, but not lipopolysaccharide-induced liver apoptosis involves changes in intracellular compartmentalization of apoptotic regulators
    Ion V Deaciuc
    Division of Gastroenterology Hepatology, College of Medicine, University of Louisville, Louisville, KY, USA
    Alcohol Clin Exp Res 28:160-72. 2004
    ..This information may prove important for future design of therapies for alcoholic liver disease...
  39. ncbi request reprint Effects of immunomodulators on acute Trypanosoma Cruzi infection in mice
    Helieh S Oz
    Department of Medicine, Division of GI Hepatology, University of Louisville, Louisville, KY 40202, USA
    Med Sci Monit 8:BR208-11. 2002
    ..In this study, effects of immunomodulators with diverse properties were examined on the course of an acute and lethal Trypanosoma cruzi infection...
  40. pmc Abrogation of nuclear factor-kappaB activation is involved in zinc inhibition of lipopolysaccharide-induced tumor necrosis factor-alpha production and liver injury
    Zhanxiang Zhou
    Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Am J Pathol 164:1547-56. 2004
    ..Thus, zinc may be beneficial in the treatment of LPS-induced liver injuries, such as sepsis and alcoholism...
  41. ncbi request reprint Advances in alcoholic liver disease
    Gavin Arteel
    University of Louisville Medical Center, Building A, Room 1319, Louisville, KY 40292, USA
    Best Pract Res Clin Gastroenterol 17:625-47. 2003
    ..Treatment of the complications of ALD can improve quality of life and, in some cases, decrease short-term mortality...
  42. ncbi request reprint Ethanol enhances activation-induced caspase-3 dependent cell death in T lymphocytes
    Sujata Kelkar
    Graduate Center for Toxicology, University of Kentucky Medical Center, Lexington, KY 40202, USA
    Alcohol Clin Exp Res 26:363-70. 2002
    ..Although it is well documented that ethanol intake can cause depletion of CD4+ T cells, the mechanism of how alcohol mediates its effects is unclear...
  43. ncbi request reprint Prevention of alterations in intestinal permeability is involved in zinc inhibition of acute ethanol-induced liver damage in mice
    Jason C Lambert
    Department of Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USA
    J Pharmacol Exp Ther 305:880-6. 2003
    ..These results thus demonstrate that zinc prevention of increased intestinal permeability is importantly involved in the inhibition of acute ethanol-induced liver damage in mice...
  44. ncbi request reprint S-Adenosylmethionine protects against acetaminophen-induced hepatotoxicity in mice
    Zhenyuan Song
    Department of Medicine, University of Louisville Medical Center, Louisville, KY 40292, USA
    Pharmacology 71:199-208. 2004
    ..We conclude that SAMe at least in part protects the liver from APAP-induced injury by preventing intracellular GSH depletion and mitochondrial dysfunction...
  45. pmc Zinc supplementation prevents alcoholic liver injury in mice through attenuation of oxidative stress
    Zhanxiang Zhou
    University of Louisville School of Medicine, Department of Medicine, 511 South Floyd St, MDR 529, Louisville, KY 40292, USA
    Am J Pathol 166:1681-90. 2005
    ..In conclusion, zinc supplementation prevents alcoholic liver injury in an metallothionein-independent manner by inhibiting the generation of reactive oxygen species (P450 2E1) and enhancing the activity of antioxidant pathways...
  46. ncbi request reprint Gene expression in the liver of rats fed alcohol by means of intragastric infusion
    Ion V Deaciuc
    College of Medicine, Department of Internal Medicine, Division of Digestive Diseases and Nutrition, 800 Rose Street, MN649A 0298, University of Kentucky, Lexington, KY 40536, USA
    Alcohol 33:17-30. 2004
    ..Further investigation of such genes may cast light on mechanisms underlying alcohol-induced liver injury and help in the design of new therapeutic approaches...
  47. ncbi request reprint Modulation of endotoxin stimulated interleukin-6 production in monocytes and Kupffer cells by S-adenosylmethionine (SAMe)
    Zhenyuan Song
    Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA
    Cytokine 28:214-23. 2004
    ..Our results demonstrate that SAMe administration may exert its anti-inflammatory and hepatoprotective effects, at least in part, by enhancing LPS-stimulated IL-6 production...
  48. ncbi request reprint Antioxidants as novel therapy in a murine model of colitis
    Helieh S Oz
    Department of Internal Medicine, Division of Digestive Diseases and Nutrition, University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Nutr Biochem 16:297-304. 2005
    ..In conclusion, three structurally dissimilar antioxidants provided protection against DSS-induced colitis in this murine model, supporting a possible role for antioxidant therapy in IBD patients...
  49. ncbi request reprint Cytokines and NASH: a pilot study of the effects of lifestyle modification and vitamin E
    Marcelo Kugelmas
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Hepatology 38:413-9. 2003
    ....
  50. ncbi request reprint Diverse antioxidants protect against acetaminophen hepatotoxicity
    Helieh S Oz
    Department of Medicine, Division of Digestive Diseases and Nutrition, University of Kentucky Medical Center, Lexington, KY 40536, USA
    J Biochem Mol Toxicol 18:361-8. 2004
    ..This is the first report that GrTP and oral administration of PTCA and SAMe can provide protection against APAP injury in this model...
  51. pmc Inactivation of hepatocyte nuclear factor-4{alpha} mediates alcohol-induced downregulation of intestinal tight junction proteins
    Wei Zhong
    Dept of Medicine, Univ of Louisville School of Medicine, KY 40292, USA
    Am J Physiol Gastrointest Liver Physiol 299:G643-51. 2010
    ..These results indicate that inactivation of HNF-4alpha due to oxidative stress and zinc deficiency is likely a novel mechanism contributing to the deleterious effects of alcohol on the tight junctions and the intestinal barrier function...
  52. ncbi request reprint Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells
    Tanvi S Jani
    Department of Pharmacology and Toxicology, University of Louisville Medical Center, 511 S Floyd, Louisville, KY 40202, USA
    Cell Res 19:358-69. 2009
    ....
  53. ncbi request reprint Ethanol inhibits methionine adenosyltransferase II activity and S-adenosylmethionine biosynthesis and enhances caspase-3-dependent cell death in T lymphocytes: relevance to alcohol-induced immunosuppression
    Prachi T Hote
    Department of Pharmacology and Toxicology, University of Louisville Medical Center, Louisville, KY 40292, USA
    J Nutr Biochem 19:384-91. 2008
    ..Furthermore, these studies provide a clinical paradigm for the development of much needed therapy using SAMe supplementation in the treatment of immune dysfunction induced by alcohol abuse...
  54. ncbi request reprint Effects of 2(RS)-n-propylthiazolidine-4(R)-carboxylic acid on 4-hydroxy-2-nonenal-induced apoptotic T cell death
    Weiyuan Chang
    Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA
    J Nutr Biochem 19:184-92. 2008
    ..This suggests that PTCA could potentially be used in the treatment of oxidative stress-induced immunosuppressive diseases...
  55. ncbi request reprint Hepatitis C and alcohol: fundamental and translational research directions
    Timothy R Morgan
    Department of Medicine, Veterans Adminstration Medical Center, Long Beach, California, USA
    Alcohol Clin Exp Res 27:726-31. 2003
    ..This article summarizes the panel's deliberations and their recommendations for future research on alcohol and hepatitis C...
  56. ncbi request reprint Obesity, inflammation, and the potential application of pharmaconutrition
    Matt C Cave
    Department of Medicine, University of Louisville School of Medicine, 500 S Jackson Street, University of Louisville, Louisville, KY 40292, USA
    Nutr Clin Pract 23:16-34. 2008
    ..A number of dietary agents such as arginine, fish oil, and carnitine may correct these problems at the molecular level. Pharmaconutrition formulas may provide exciting innovations for the nutrition therapy of the obese patient...
  57. ncbi request reprint Toxicant-associated steatohepatitis in vinyl chloride workers
    Matt Cave
    Department of Medicine, Division of Gastroenterology and Hepatology, University of Louisville, Louisville, KY 40202, USA
    Hepatology 51:474-81. 2010
    ..TASH was also associated with markedly elevated serum tumor necrosis factor alpha and interleukins 1beta, 6, and 8. Serum antioxidant activity was reduced in TASH...
  58. ncbi request reprint 4-Hydroxynonenal-induced apoptosis in rat hepatic stellate cells: mechanistic approach
    Willem J S de Villiers
    Division of Digestive Diseases, Department of Internal Medicine, University of Kentucky Medical Center, Lexington, USA
    J Gastroenterol Hepatol 22:414-22. 2007
    ..In this study we determined if: (i) 4-hydroxy-2,3-nonenal (HNE) induces apoptosis in two rat stellate cell lines, HSC-T6 and CFSC-2G; and (ii) if apoptosis is regulated at the transcriptional and/or translational level...
  59. ncbi request reprint Diagnosis and treatment of alcoholic liver disease and its complications
    Luis S Marsano
    Department of Internal Medicine, University of Louisville Medical Center, Louisville, Kentucky, USA
    Alcohol Res Health 27:247-56. 2003
    ..The diagnosis and management of the complications of ALD are important for alleviating the symptoms of the disease, improving quality of life, and decreasing mortality...
  60. pmc Treatment of alcoholic liver disease
    Ina Bergheim
    Department of Pharmacology and Toxicology, University of Louisville Health Sciences Center, Louisville, KY 40292, USA
    Dig Dis 23:275-84. 2005
    ..Treatment of the complications of ALD can improve the quality of life and, in some cases, decrease short-term mortality...
  61. doi request reprint Drug-induced hepatotoxicity or drug-induced liver injury
    Aaron J Pugh
    Department of Medicine, University of Louisville School of Medicine, 550 South Jackson Street, Louisville, KY 40292, USA
    Clin Liver Dis 13:277-94. 2009
    ....
  62. ncbi request reprint Epidermal growth factor protects the liver against alcohol-induced injury and sensitization to bacterial lipopolysaccharide
    Ion V Deaciuc
    Division of Digestive Diseases, A B Chandler Medical Center, University of Kentucky, Lexington 40536, USA
    Alcohol Clin Exp Res 26:864-74. 2002
    ....
  63. doi request reprint Antibiotics protect against fructose-induced hepatic lipid accumulation in mice: role of endotoxin
    Ina Bergheim
    Department of Nutritional Medicine 180, University of Hohenheim, Fruwirthstrasse 12, 70599 Stuttgart, Germany
    J Hepatol 48:983-92. 2008
    ..The aim of the present study was to test the effects of ad libitum access to different sugars consumed in drinking water on hepatic fat accumulation...
  64. ncbi request reprint Chronic intragastric alcohol exposure causes hypoxia and oxidative stress in the rat pancreas
    Stephen E McKim
    Laboratory of Hepatobiology and Toxicology, Department of Pharmacology, University of North Carolina, Chapel Hill, NC, USA
    Arch Biochem Biophys 417:34-43. 2003
    ..These results indicate that chronic ethanol causes hypoxia at the cellular level in the pancreas in vivo; further, the data support the hypothesis that hypoxia is involved in mechanisms of chronic alcoholic pancreatitis...
  65. ncbi request reprint Anti-TNF-alpha antibody normalizes serum leptin in IL-2 deficient mice
    Lisa M Gaetke
    Department of Nutrition and Food Science, University of Kentucky, and the Lexington Veterans Administration Medical Center, Lexington 40506 0054, USA
    J Am Coll Nutr 22:415-20. 2003
    ..The objective of this study was to examine whether increased tumor necrosis factor-alpha (TNF-alpha), a pro-inflammatory cytokine, contributes to the abnormally elevated leptin in IL-2(-/-) mice...
  66. ncbi request reprint Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium
    Vishnudutt Purohit
    Division of Metabolism and Health Effects, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Am J Clin Nutr 86:14-24. 2007
    ..Additionally, decreased concentrations of homocysteine can down-regulate endoplasmic reticulum stress, which leads to the attenuation of apoptosis and fatty acid synthesis...
  67. ncbi request reprint Pancreatic response to endotoxin after chronic alcohol exposure: switch from apoptosis to necrosis?
    Franco Fortunato
    University Hospital Zurich, Department of Visceral and Transplantation Surgery, Sternwartstrasse 14, CH 8091 Zurich, Switzerland
    Am J Physiol Gastrointest Liver Physiol 290:G232-41. 2006
    ..We speculate that this mechanism may occur in acute alcoholic pancreatitis patients...
  68. ncbi request reprint Nutrition and nonalcoholic fatty liver disease in children
    Miriam B Vos
    Department of Pediatrics, Emory University, 2015 Uppergate Drive NE, Atlanta, GA 30322, USA
    Curr Gastroenterol Rep 10:308-15. 2008
    ..The available treatment studies using nutrition counseling and increased physical activity are promising. We recommend initiating sustainable family-oriented lifestyle changes in all children with NAFLD...
  69. ncbi request reprint Anti-TNF therapy in alcoholic hepatitis
    Daniell B Hill
    Am J Gastroenterol 99:261-3. 2004
  70. ncbi request reprint Good fat/bad fat
    Craig J McClain
    Hepatology 45:1343-6. 2007
  71. ncbi request reprint Infliximab and prednisolone: too much of a good thing?
    Craig J McClain
    Hepatology 39:1488-90. 2004

Research Grants31

  1. A.S.P.E.N. Research Workshop on Functional Foods
    Craig McClain; Fiscal Year: 2002
    ..abstract_text> ..
  2. S-adenosylhomocysteine and S-adenosylmethionine in Alcoholic Liver Disease
    Craig McClain; Fiscal Year: 2007
    ..These studies utilize state-of-the-art models/techniques in a translational approach to develop an enhanced understanding of mechanisms involved in ALD and potential new therapy for ALD. ..
  3. Mechanisms of S-adenosylmethionine in NASH
    Craig McClain; Fiscal Year: 2006
    ..Determine by proteomic analysis of serum and liver biopsies the proteins (esp. oxidative stress, oxidized and mitochondrial proteins) that may play a role in the diagnosis or etiology of NASH, and which may be modified by SAMe therapy ..
  4. Planning Grant for Louisville Clinical and Translational Science Award
    Craig McClain; Fiscal Year: 2006
    ..Expand and integrate a clinical and translational research resources and outreach network. ..
  5. S-adenosylhomocysteine and S-adenosylmethionine in Alcoholic Liver Disease
    Craig McClain; Fiscal Year: 2006
    ..These studies utilize state-of-the-art models/techniques in a translational approach to develop an enhanced understanding of mechanisms involved in ALD and potential new therapy for ALD. ..
  6. Mechanisms of S-adenosylmethionine in NASH
    Craig McClain; Fiscal Year: 2009
    ..Determine by proteomic analysis of serum and liver biopsies the proteins (esp. oxidative stress, oxidized and mitochondrial proteins) that may play a role in the diagnosis or etiology of NASH, and which may be modified by SAMe therapy ..
  7. The Role of Alcohol in HIV Therapy Hepatotoxicity
    CRAIG J contact MCCLAIN; Fiscal Year: 2010
    ..Here, we will study hepatotoxicity due to alcohol/HAART interactions to further define disease mechanisms and create therapeutic interventions. ..
  8. Mechanisms of S-adenosylmethionine in NASH
    Craig McClain; Fiscal Year: 2007
    ..Determine by proteomic analysis of serum and liver biopsies the proteins (esp. oxidative stress, oxidized and mitochondrial proteins) that may play a role in the diagnosis or etiology of NASH, and which may be modified by SAMe therapy ..
  9. S-adenosylhomocysteine and S-adenosylmethionine in Alcoholic Liver Disease
    Craig McClain; Fiscal Year: 2009
    ..These studies utilize state-of-the-art models/techniques in a translational approach to develop an enhanced understanding of mechanisms involved in ALD and potential new therapy for ALD. ..
  10. The Role of Alcohol in HIV Therapy Hepatotoxicity
    Craig McClain; Fiscal Year: 2009
    ..Here, we will study hepatotoxicity due to alcohol/HAART interactions to further define disease mechanisms and create therapeutic interventions. ..
  11. S-adenosylhomocysteine and S-adenosylmethionine in Alcoholic Liver Disease
    Craig McClain; Fiscal Year: 2005
    ..These studies utilize state-of-the-art models/techniques in a translational approach to develop an enhanced understanding of mechanisms involved in ALD and potential new therapy for ALD. ..
  12. Cyclic AMP, Cytokine Modulation and Alcoholic Liver Disease
    Craig McClain; Fiscal Year: 2009
    ..The major problem to be investigated in this proposal is the mechanism(s) for this dysregulated cytokine metabolism, and our overall goal is the development of novel therapeutic interventions. ..
  13. The Role of Alcohol in HIV Therapy Hepatotoxicity
    Craig McClain; Fiscal Year: 2009
    ..Here, we will study hepatotoxicity due to alcohol/HAART interactions to further define disease mechanisms and create therapeutic interventions. ..
  14. S-adenosylhomocysteine and S-adenosylmethionine in Alcoholic Liver Disease
    Craig McClain; Fiscal Year: 2009
    ..These studies utilize state-of-the-art models/techniques in a translational approach to develop an enhanced understanding of mechanisms involved in ALD and potential new therapy for ALD. ..
  15. Cyclic AMP, Cytokine Modulation and Alcoholic Liver Disease
    Craig J McClain; Fiscal Year: 2010
    ..The major problem to be investigated in this proposal is the mechanism(s) for this dysregulated cytokine metabolism, and our overall goal is the development of novel therapeutic interventions. ..
  16. S-adenosylhomocysteine and S-adenosylmethionine in Alcoholic Liver Disease
    Craig McClain; Fiscal Year: 2007
    ..These studies utilize state-of-the-art models/techniques in a translational approach to develop an enhanced understanding of mechanisms involved in ALD and potential new therapy for ALD. ..
  17. Mechanisms of S-adenosylmethionine in NASH
    Craig McClain; Fiscal Year: 2005
    ..Determine by proteomic analysis of serum and liver biopsies the proteins (esp. oxidative stress, oxidized and mitochondrial proteins) that may play a role in the diagnosis or etiology of NASH, and which may be modified by SAMe therapy ..
  18. S-adenosylhomocysteine and S-adenosylmethionine in Alcoholic Liver Disease
    Craig McClain; Fiscal Year: 2007
    ..These studies utilize state-of-the-art models/techniques in a translational approach to develop an enhanced understanding of mechanisms involved in ALD and potential new therapy for ALD. ..
  19. TNF and Mitochondrial Dysfunction in ALD
    Craig McClain; Fiscal Year: 2007
    ..abstract_text> ..
  20. S-adenosylhomocysteine and S-adenosylmethionine in Alcoholic Liver Disease
    Craig J McClain; Fiscal Year: 2010
    ..These studies utilize state-of-the-art models/techniques in a translational approach to develop an enhanced understanding of mechanisms involved in ALD and potential new therapy for ALD. ..