Research Topics
| CHRISTOPHER MCCARTNEYSummaryAffiliation: University of Virginia Country: USA Publications
Research Grants
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Detail Information
Publications
Regulation of gonadotropin secretion: implications for polycystic ovary syndromeChristopher R McCartney
Center for Research in Reproduction, Division of Endocrinology, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia, USA
Semin Reprod Med 20:317-26. 2002....- Hypothalamic regulation of cyclic ovulation: evidence that the increase in gonadotropin-releasing hormone pulse frequency during the follicular phase reflects the gradual loss of the restraining effects of progesteroneChristopher R McCartney
Division of Endocrinology, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Clin Endocrinol Metab 87:2194-200. 2002..This supports the hypothesis that the increasing GnRH pulse frequency throughout the follicular phase reflects the gradual loss of the inhibitory actions of low concentrations of P... 
Maturation of sleep-wake gonadotrophin-releasing hormone secretion across puberty in girls: potential mechanisms and relevance to the pathogenesis of polycystic ovary syndromeC R McCartney
Division of Endocrinology and Metabolism, Department of Medicine, Center for Research in Reproduction, University of Virginia Health System, Charlottesville, VA 22908, USA
J Neuroendocrinol 22:701-9. 2010..How this model may be relevant to the genesis of abnormal GnRH secretion in peripubertal girls with hyperandrogenaemia is then described...- Exaggerated 17-hydroxyprogesterone response to intravenous infusions of recombinant human LH in women with polycystic ovary syndromeChristopher R McCartney
Center for Research in Reproduction, Division of Endocrinology, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
Am J Physiol Endocrinol Metab 286:E902-8. 2004..Defining the precise mechanistic basis of heightened precursor responsiveness to LH in PCOS will require further clinical investigation... - Estradiol and progesterone-induced slowing of gonadotropin-releasing hormone pulse frequency is not reversed by subsequent administration of mifepristoneChristopher R McCartney
Center for Research in Reproduction, University of Virginia Health System, Box 800391, Charlottesville, VA, 22908, USA
Endocrine 36:239-45. 2009.... - The association of obesity and hyperandrogenemia during the pubertal transition in girls: obesity as a potential factor in the genesis of postpubertal hyperandrogenismChristopher R McCartney
The Center for Research in Reproduction and Division of Endocrinology, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Clin Endocrinol Metab 91:1714-22. 2006..Adolescent hyperandrogenemia is considered a forerunner of adult polycystic ovary syndrome, but its etiology remains uncertain... - Obesity and sex steroid changes across puberty: evidence for marked hyperandrogenemia in pre- and early pubertal obese girlsChristopher R McCartney
Center for Research in Reproduction, Box 800391, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Clin Endocrinol Metab 92:430-6. 2007..Peripubertal obesity is associated with abnormal sex steroid concentrations, but the timing of onset and degree of these abnormalities remain unclear... - Progesterone acutely increases LH pulse amplitude but does not acutely influence nocturnal LH pulse frequency slowing during the late follicular phase in womenChristopher R McCartney
Center for Research in Reproduction, Box 800391, Department of Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
Am J Physiol Endocrinol Metab 292:E900-6. 2007.... - Maturation of luteinizing hormone (gonadotropin-releasing hormone) secretion across puberty: evidence for altered regulation in obese peripubertal girlsChristopher R McCartney
Division of Endocrinology and Metabolism, Department of Medicine, Box 800391, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Clin Endocrinol Metab 94:56-66. 2009..Peripubertal obesity (body mass index-for-age >or= 95%) in girls is associated with hyperandrogenemia. LH likely contributes to this relationship, but overnight LH secretion in obese girls is poorly characterized... - Decision analysis of discordant thyroid nodule biopsy guideline criteriaChristopher R McCartney
Division of Endocrinology and Metabolism, Department of Medicine, Box 800391, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Clin Endocrinol Metab 93:3037-44. 2008..Recently published guidelines are discordant regarding diagnostic approaches to small (10-14 mm) thyroid nodules... - Obesity and the pubertal transition in girls and boysChristine M Burt Solorzano
Division of Endocrinology, Department of Pediatrics Center for Research in Reproduction Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health System, PO Box 800391, Charlottesville, Virginia 22908, USA
Reproduction 140:399-410. 2010..Our understanding of obesity's impact on pubertal development is in its infancy, and more research into pathophysiological mechanisms and longer-term sequelae is important... 
Polycystic ovary syndrome in adolescenceSusan K Blank
The Center for Research in Reproduction, Box 800391, University of Virginia Health System, Charlottesville, VA 22908, USA
Ann N Y Acad Sci 1135:76-84. 2008..Recognizing and reducing androgen levels in adolescence is critical given their association with the metabolic syndrome (MBS), diabetes, and infertility in adulthood...- Modulation of gonadotropin-releasing hormone pulse generator sensitivity to progesterone inhibition in hyperandrogenic adolescent girls--implications for regulation of pubertal maturationSusan K Blank
Center for Research in Reproduction and Division of Endocrinology, Department of Internal Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Clin Endocrinol Metab 94:2360-6. 2009..This defect is androgen mediated because it is reversed with androgen receptor blockade. Adolescent hyperandrogenism often precedes PCOS... - Progesterone inhibition of the hypothalamic gonadotropin-releasing hormone pulse generator: evidence for varied effects in hyperandrogenemic adolescent girlsSandhya Chhabra
Center for Research in Reproduction, Division of Endocrinology, Department of Internal Medicine, Box 800391, University of Virginia Health System, Charlottesville, Virginia 22908, USA
J Clin Endocrinol Metab 90:2810-5. 2005..These data suggest that hyperandrogenemia during adolescence is variably associated with decreased sensitivity to P, which may have a partially genetic basis... - Neuroendocrine effects of androgens in adult polycystic ovary syndrome and female pubertySusan K Blank
The Center for Research in Reproduction, University of Virginia Health System, Charlottesville, VA 22908, USA
Semin Reprod Med 25:352-9. 2007..Over time, these abnormalities may progress to the clinical hyperandrogenism and chronic oligo-ovulation typical of adult PCOS...
Research Grants
- Progesterone Modulation of Pulsatile GnRH SecretionCHRISTOPHER MCCARTNEY; Fiscal Year: 2007..McCartney's development into an independent patient-oriented investigator in the field of reproductive endocrinology. ..
- Pubertal hyperandrogenemia, modification of day-night GnRH secretion, and PCOSCHRISTOPHER MCCARTNEY; Fiscal Year: 2009....
- Pubertal hyperandrogenemia, modification of day-night GnRH secretion, and PCOSChristopher R McCartney; Fiscal Year: 2010....
- Pubertal hyperandrogenemia, modification of day-night GnRH secretion, and PCOSChristopher R McCartney; Fiscal Year: 2010....