John J McCarthy

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy
    John J McCarthy
    Department of Physiology, University of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
    J Appl Physiol (1985) 102:306-13. 2007
  2. doi The MyomiR network in skeletal muscle plasticity
    John J McCarthy
    Department of Physiology and Center for Muscle Biology, University of Kentucky, Lexington, USA
    Exerc Sport Sci Rev 39:150-4. 2011
  3. pmc Evidence of MyomiR network regulation of beta-myosin heavy chain gene expression during skeletal muscle atrophy
    John J McCarthy
    Department of Physiology, College Health Sciences, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Physiol Genomics 39:219-26. 2009
  4. pmc MicroRNA-206: the skeletal muscle-specific myomiR
    John J McCarthy
    Department of Physiology, University of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
    Biochim Biophys Acta 1779:682-91. 2008
  5. ncbi MicroRNA-206 is overexpressed in the diaphragm but not the hindlimb muscle of mdx mouse
    John J McCarthy
    Dept of Physiology, University of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
    Am J Physiol Cell Physiol 293:C451-7. 2007
  6. ncbi Regulation of the muscle fiber microenvironment by activated satellite cells during hypertrophy
    Christopher S Fry
    1900 S Limestone, CTW 105, University of Kentucky, Lexington, KY 40536, USA
    FASEB J 28:1654-65. 2014
  7. pmc Satellite cell depletion does not inhibit adult skeletal muscle regrowth following unloading-induced atrophy
    Janna R Jackson
    Department of Rehabilitation Sciences, College of Health Sciences, University of Kentucky, Lexington, 40536 0200, USA
    Am J Physiol Cell Physiol 303:C854-61. 2012
  8. pmc Time course of gene expression during mouse skeletal muscle hypertrophy
    Thomas Chaillou
    Center for Muscle Biology, University of Kentucky, Lexington, Kentucky
    J Appl Physiol (1985) 115:1065-74. 2013
  9. ncbi Identification of the circadian transcriptome in adult mouse skeletal muscle
    John J McCarthy
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536, USA
    Physiol Genomics 31:86-95. 2007
  10. doi MicroRNAs in skeletal muscle biology and exercise adaptation
    Tyler J Kirby
    Department of Physiology and University of Kentucky, Lexington, KY 40516 0298, USA
    Free Radic Biol Med 64:95-105. 2013

Collaborators

Detail Information

Publications24

  1. ncbi MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy
    John J McCarthy
    Department of Physiology, University of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
    J Appl Physiol (1985) 102:306-13. 2007
    ..These results are the first to report alterations in expression of muscle-specific miRNAs in adult skeletal muscle and suggest miRNAs may have a role in the adaptation to functional overload...
  2. doi The MyomiR network in skeletal muscle plasticity
    John J McCarthy
    Department of Physiology and Center for Muscle Biology, University of Kentucky, Lexington, USA
    Exerc Sport Sci Rev 39:150-4. 2011
    ....
  3. pmc Evidence of MyomiR network regulation of beta-myosin heavy chain gene expression during skeletal muscle atrophy
    John J McCarthy
    Department of Physiology, College Health Sciences, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    Physiol Genomics 39:219-26. 2009
    ..These results further expand the role of miRs in adult skeletal muscle and are consistent with a model in which the MyomiR network regulates slow myosin expression during muscle atrophy...
  4. pmc MicroRNA-206: the skeletal muscle-specific myomiR
    John J McCarthy
    Department of Physiology, University of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
    Biochim Biophys Acta 1779:682-91. 2008
    ..The review is also intended to serve as a comprehensive resource for miR-206 with the hope of encouraging further research on the role of miR-206 in skeletal muscle...
  5. ncbi MicroRNA-206 is overexpressed in the diaphragm but not the hindlimb muscle of mdx mouse
    John J McCarthy
    Dept of Physiology, University of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
    Am J Physiol Cell Physiol 293:C451-7. 2007
    ..These results are the first to report alterations in expression of muscle-enriched microRNAs in skeletal muscle of the mdx mouse, suggesting microRNAs may have a role in the pathophysiology of muscular dystrophy...
  6. ncbi Regulation of the muscle fiber microenvironment by activated satellite cells during hypertrophy
    Christopher S Fry
    1900 S Limestone, CTW 105, University of Kentucky, Lexington, KY 40536, USA
    FASEB J 28:1654-65. 2014
    ..These results provide evidence that satellite cells regulate the muscle environment during growth...
  7. pmc Satellite cell depletion does not inhibit adult skeletal muscle regrowth following unloading-induced atrophy
    Janna R Jackson
    Department of Rehabilitation Sciences, College of Health Sciences, University of Kentucky, Lexington, 40536 0200, USA
    Am J Physiol Cell Physiol 303:C854-61. 2012
    ..These results provide convincing evidence that satellite cells are not required for muscle regrowth following atrophy and that, instead, the myonuclear domain size changes as myofibers adapt...
  8. pmc Time course of gene expression during mouse skeletal muscle hypertrophy
    Thomas Chaillou
    Center for Muscle Biology, University of Kentucky, Lexington, Kentucky
    J Appl Physiol (1985) 115:1065-74. 2013
    ....
  9. ncbi Identification of the circadian transcriptome in adult mouse skeletal muscle
    John J McCarthy
    Department of Physiology, University of Kentucky, Lexington, Kentucky 40536, USA
    Physiol Genomics 31:86-95. 2007
    ....
  10. doi MicroRNAs in skeletal muscle biology and exercise adaptation
    Tyler J Kirby
    Department of Physiology and University of Kentucky, Lexington, KY 40516 0298, USA
    Free Radic Biol Med 64:95-105. 2013
    ..The roles of miRNAs in satellite cell biology, muscle regeneration, and various myopathies are also discussed. ..
  11. pmc Inducible Cre transgenic mouse strain for skeletal muscle-specific gene targeting
    John J McCarthy
    Center for Muscle Biology, University of Kentucky, Lexington, KY, 40536, USA
    Skelet Muscle 2:8. 2012
    ..abstract:..
  12. pmc A non-canonical E-box within the MyoD core enhancer is necessary for circadian expression in skeletal muscle
    Xiping Zhang
    Center for Muscle Biology, Department of Physiology, University of Kentucky, Lexington, KY 40536, USA
    Nucleic Acids Res 40:3419-30. 2012
    ....
  13. pmc Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling
    Mitsunori Miyazaki
    Center for Muscle Biology, Department of Physiology, College of Medicine, University of Kentucky, 800 Rose Street, UKMC MS508, Lexington, KY 40536, USA
    J Physiol 589:1831-46. 2011
    ....
  14. pmc Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubes
    Mitsunori Miyazaki
    Center for Muscle Biology, Department of Physiology, University of Kentucky, Lexington, USA
    FEBS J 277:2180-91. 2010
    ..We suggest that this translocation is likely critical for mTOR activation by dissociating the interaction between the GTPase activating protein activity of the TSC1/TSC2 complex and its downstream target, Ras homolog enriched in brain...
  15. doi Mice lacking the transient receptor vanilloid potential 1 channel display normal thirst responses and central Fos activation to hypernatremia
    A Caitlynn Taylor
    Department of Physiology, University of Kentucky, Lexington, KY 40536, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1285-93. 2008
    ....
  16. pmc Effective fiber hypertrophy in satellite cell-depleted skeletal muscle
    John J McCarthy
    Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
    Development 138:3657-66. 2011
    ..These results provide convincing evidence that skeletal muscle fibers are capable of mounting a robust hypertrophic response to mechanical overload that is not dependent on satellite cells...
  17. pmc Anabolic and catabolic pathways regulating skeletal muscle mass
    John J McCarthy
    Center for Muscle Biology, Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, USA
    Curr Opin Clin Nutr Metab Care 13:230-5. 2010
    ..The purpose of this review is to discuss recent findings as they pertain to anabolic and catabolic-signaling pathways involved in the regulation of adult skeletal muscle mass...
  18. ncbi Voluntary wheel running ameliorates vascular smooth muscle hyper-contractility in type 2 diabetic db/db mice
    Karyn A Esser
    Department of Physiology and Graduate Center for Nutritional Sciences, University of Kentucky, 509 Wethington Building, 900 South Limestone, Lexington, KY 40536, USA
    Appl Physiol Nutr Metab 32:711-20. 2007
    ..However, the low levels of running were beneficial, in the absence of effects on obesity or blood glucose, with significant reductions in cardiovascular risk factors and potential delays in beta-cell dysfunction...
  19. pmc Excess dietary salt alters angiotensinergic regulation of neurons in the rostral ventrolateral medulla
    Julye M Adams
    Department of Physiology, University of Kentucky, Lexington, KY 40536 0298, USA
    Hypertension 52:932-7. 2008
    ..Moreover, elevated dietary salt intake differentially affects the tonic activity of the peripheral versus brain RVLM Ang II type 1 receptors to regulate baseline SNA and ABP...
  20. ncbi Counterpoint: Satellite cell addition is not obligatory for skeletal muscle hypertrophy
    John J McCarthy
    J Appl Physiol 103:1100-2; discussion 1102-3. 2007
  21. pmc Puralpha and Purbeta collaborate with Sp3 to negatively regulate beta-myosin heavy chain gene expression during skeletal muscle inactivity
    Juan Ji
    Department of Biochemistry, School of Medicine, University of Missouri Columbia, 1201 Rollins Road, Columbia, MO 65211, USA
    Mol Cell Biol 27:1531-43. 2007
    ..These data demonstrate that Pur proteins collaborate with Sp3 to regulate a transcriptional program that enables muscle cells to remodel their phenotype...
  22. pmc Evaluation of developmental phenotypes produced by morpholino antisense targeting of a sea urchin Runx gene
    James A Coffman
    Stowers Institute for Medical Research, 1000 E, 50th Street, Kansas City, MO 64110, USA
    BMC Biol 2:6. 2004
    ..Here we extend the functional analysis of SpRunt, using morpholino antisense oligonucleotides (morpholinos) to interfere with SpRunt expression in the embryo...
  23. pmc The sea urchin stem-loop-binding protein: a maternally expressed protein that probably functions in expression of multiple classes of histone mRNA
    Anthony J Robertson
    Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill 27599, USA
    Nucleic Acids Res 32:811-8. 2004
    ..SuSLBP expressed by in vitro translation does not bind the stem-loop RNA, suggesting that suSLBP is modified to activate RNA binding in sea urchin embryos...