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Genomes and Genes | John J McCarthySummaryAffiliation: University of Kentucky Country: USA Publications
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Publications
MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophyJohn J McCarthy
Department of Physiology, University of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
J Appl Physiol 102:306-13. 2007..These results are the first to report alterations in expression of muscle-specific miRNAs in adult skeletal muscle and suggest miRNAs may have a role in the adaptation to functional overload...- MicroRNA-206 is overexpressed in the diaphragm but not the hindlimb muscle of mdx mouseJohn J McCarthy
Dept of Physiology, University of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
Am J Physiol Cell Physiol 293:C451-7. 2007..These results are the first to report alterations in expression of muscle-enriched microRNAs in skeletal muscle of the mdx mouse, suggesting microRNAs may have a role in the pathophysiology of muscular dystrophy... 
Evidence of MyomiR network regulation of beta-myosin heavy chain gene expression during skeletal muscle atrophyJohn J McCarthy
Department of Physiology, College Health Sciences, University of Kentucky, Lexington, Kentucky 40536 0298, USA
Physiol Genomics 39:219-26. 2009..These results further expand the role of miRs in adult skeletal muscle and are consistent with a model in which the MyomiR network regulates slow myosin expression during muscle atrophy...
The MyomiR network in skeletal muscle plasticityJohn J McCarthy
Department of Physiology and Center for Muscle Biology, University of Kentucky, Lexington, USA
Exerc Sport Sci Rev 39:150-4. 2011....- MicroRNA-206: the skeletal muscle-specific myomiRJohn J McCarthy
Department of Physiology, University of Kentucky Medical Center, 800 Rose St, Lexington, KY 40536 0298, USA
Biochim Biophys Acta 1779:682-91. 2008..The review is also intended to serve as a comprehensive resource for miR-206 with the hope of encouraging further research on the role of miR-206 in skeletal muscle... - Satellite cell depletion does not inhibit adult skeletal muscle regrowth following unloading-induced atrophyJanna R Jackson
Department of Rehabilitation Sciences, College of Health Sciences, University of Kentucky, Lexington, 40536 0200, USA
Am J Physiol Cell Physiol 303:C854-61. 2012..These results provide convincing evidence that satellite cells are not required for muscle regrowth following atrophy and that, instead, the myonuclear domain size changes as myofibers adapt... - Identification of the circadian transcriptome in adult mouse skeletal muscleJohn J McCarthy
Department of Physiology, University of Kentucky, Lexington, Kentucky 40536, USA
Physiol Genomics 31:86-95. 2007.... - Inducible Cre transgenic mouse strain for skeletal muscle-specific gene targetingJohn J McCarthy
Center for Muscle Biology, University of Kentucky, Lexington, KY, 40536, USA
Skelet Muscle 2:8. 2012..abstract:.. - A non-canonical E-box within the MyoD core enhancer is necessary for circadian expression in skeletal muscleXiping Zhang
Center for Muscle Biology, Department of Physiology, University of Kentucky, Lexington, KY 40536, USA
Nucleic Acids Res 40:3419-30. 2012.... - Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signallingMitsunori Miyazaki
Center for Muscle Biology, Department of Physiology, College of Medicine, University of Kentucky, 800 Rose Street, UKMC MS508, Lexington, KY 40536, USA
J Physiol 589:1831-46. 2011.... - Mice lacking the transient receptor vanilloid potential 1 channel display normal thirst responses and central Fos activation to hypernatremiaA Caitlynn Taylor
Department of Physiology, University of Kentucky, Lexington, KY 40536, USA
Am J Physiol Regul Integr Comp Physiol 294:R1285-93. 2008.... - Insulin like growth factor-1-induced phosphorylation and altered distribution of tuberous sclerosis complex (TSC)1/TSC2 in C2C12 myotubesMitsunori Miyazaki
Center for Muscle Biology, Department of Physiology, University of Kentucky, Lexington, USA
FEBS J 277:2180-91. 2010..We suggest that this translocation is likely critical for mTOR activation by dissociating the interaction between the GTPase activating protein activity of the TSC1/TSC2 complex and its downstream target, Ras homolog enriched in brain... - Voluntary wheel running ameliorates vascular smooth muscle hyper-contractility in type 2 diabetic db/db miceKaryn A Esser
Department of Physiology and Graduate Center for Nutritional Sciences, University of Kentucky, 509 Wethington Building, 900 South Limestone, Lexington, KY 40536, USA
Appl Physiol Nutr Metab 32:711-20. 2007..However, the low levels of running were beneficial, in the absence of effects on obesity or blood glucose, with significant reductions in cardiovascular risk factors and potential delays in beta-cell dysfunction... - Anabolic and catabolic pathways regulating skeletal muscle massJohn J McCarthy
Center for Muscle Biology, Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, USA
Curr Opin Clin Nutr Metab Care 13:230-5. 2010..The purpose of this review is to discuss recent findings as they pertain to anabolic and catabolic-signaling pathways involved in the regulation of adult skeletal muscle mass... - Effective fiber hypertrophy in satellite cell-depleted skeletal muscleJohn J McCarthy
Department of Physiology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
Development 138:3657-66. 2011..These results provide convincing evidence that skeletal muscle fibers are capable of mounting a robust hypertrophic response to mechanical overload that is not dependent on satellite cells... - Excess dietary salt alters angiotensinergic regulation of neurons in the rostral ventrolateral medullaJulye M Adams
Department of Physiology, University of Kentucky, Lexington, KY 40536 0298, USA
Hypertension 52:932-7. 2008..Moreover, elevated dietary salt intake differentially affects the tonic activity of the peripheral versus brain RVLM Ang II type 1 receptors to regulate baseline SNA and ABP... - Counterpoint: Satellite cell addition is not obligatory for skeletal muscle hypertrophyJohn J McCarthy
J Appl Physiol 103:1100-2; discussion 1102-3. 2007 - Puralpha and Purbeta collaborate with Sp3 to negatively regulate beta-myosin heavy chain gene expression during skeletal muscle inactivityJuan Ji
Department of Biochemistry, School of Medicine, University of Missouri Columbia, 1201 Rollins Road, Columbia, MO 65211, USA
Mol Cell Biol 27:1531-43. 2007..These data demonstrate that Pur proteins collaborate with Sp3 to regulate a transcriptional program that enables muscle cells to remodel their phenotype... - Evaluation of developmental phenotypes produced by morpholino antisense targeting of a sea urchin Runx geneJames A Coffman
Stowers Institute for Medical Research, 1000 E, 50th Street, Kansas City, MO 64110, USA
BMC Biol 2:6. 2004..Here we extend the functional analysis of SpRunt, using morpholino antisense oligonucleotides (morpholinos) to interfere with SpRunt expression in the embryo... - The sea urchin stem-loop-binding protein: a maternally expressed protein that probably functions in expression of multiple classes of histone mRNAAnthony J Robertson
Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill 27599, USA
Nucleic Acids Res 32:811-8. 2004..SuSLBP expressed by in vitro translation does not bind the stem-loop RNA, suggesting that suSLBP is modified to activate RNA binding in sea urchin embryos...