John J McCarthy
Affiliation: University of Kentucky
McCarthy J, Esser K. MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy. J Appl Physiol (1985). 2007;102:306-13 pubmed
..These results are the first to report alterations in expression of muscle-specific miRNAs in adult skeletal muscle and suggest miRNAs may have a role in the adaptation to functional overload. ..
Vechetti I, Wen Y, Chaillou T, Murach K, Alimov A, Figueiredo V, et al
. Life-long reduction in myomiR expression does not adversely affect skeletal muscle morphology. Sci Rep. 2019;9:5483 pubmed publisher
..These results indicate the life-long reduction in myomiR levels did not adversely affect skeletal muscle phenotype and suggest the possibility that microRNA expression is uniquely regulated in skeletal muscle. ..
Iwata M, Englund D, Wen Y, Dungan C, Murach K, Vechetti I, et al
. A novel tetracycline-responsive transgenic mouse strain for skeletal muscle-specific gene expression. Skelet Muscle. 2018;8:33 pubmed publisher
..The HSA-rtTA transgenic mouse allows for robust, specific, and inducible gene expression across muscles of different fiber types. The HSA-rtTA mouse provides a powerful tool to manipulate gene expression in skeletal muscle. ..
Murach K, McCarthy J. MicroRNAs, heart failure, and aging: potential interactions with skeletal muscle. Heart Fail Rev. 2017;22:209-218 pubmed publisher
..An overview of miRNA alterations in skeletal muscle during the ubiquitous process of aging and perspectives on miRNA interactions during heart failure are also provided. ..
Fry C, Kirby T, Kosmac K, McCarthy J, Peterson C. Myogenic Progenitor Cells Control Extracellular Matrix Production by Fibroblasts during Skeletal Muscle Hypertrophy. Cell Stem Cell. 2017;20:56-69 pubmed publisher
..These findings provide insights intoÂ how skeletal stem and progenitor cells interact with other cell types to actively regulate their extracellular environments for tissue maintenance and adaptation. ..
McCarthy J, Esser K, Andrade F. MicroRNA-206 is overexpressed in the diaphragm but not the hindlimb muscle of mdx mouse. Am J Physiol Cell Physiol. 2007;293:C451-7 pubmed
..These results are the first to report alterations in expression of muscle-enriched microRNAs in skeletal muscle of the mdx mouse, suggesting microRNAs may have a role in the pathophysiology of muscular dystrophy. ..
McCarthy J, Esser K, Peterson C, Dupont Versteegden E. Evidence of MyomiR network regulation of beta-myosin heavy chain gene expression during skeletal muscle atrophy. Physiol Genomics. 2009;39:219-26 pubmed publisher
..These results further expand the role of miRs in adult skeletal muscle and are consistent with a model in which the MyomiR network regulates slow myosin expression during muscle atrophy. ..
McCarthy J. The MyomiR network in skeletal muscle plasticity. Exerc Sport Sci Rev. 2011;39:150-4 pubmed publisher
Kirby T, Lee J, England J, Chaillou T, Esser K, McCarthy J. Blunted hypertrophic response in aged skeletal muscle is associated with decreased ribosome biogenesis. J Appl Physiol (1985). 2015;119:321-7 pubmed publisher
..The diminished increase in total RNA, pre-47S rRNA, and 28S rRNA expression in aged muscle suggest that the primary dysfunction in ribosome biogenesis occurs at the level of rRNA transcription and processing. ..