Peter McCaffery

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi Retinoid quantification by HPLC/MS(n)
    Peter McCaffery
    University of Massachusetts, E K Shriver Center, Waltham, MA, USA
    J Lipid Res 43:1143-9. 2002
  2. ncbi Too much of a good thing: retinoic acid as an endogenous regulator of neural differentiation and exogenous teratogen
    P J McCaffery
    UMMS E K Shriver Center, Waltham, MA USA
    Eur J Neurosci 18:457-72. 2003
  3. ncbi Retinoic acid signaling and function in the adult hippocampus
    Peter McCaffery
    UMMS E K Shriver Center, Waltham, Massachusetts 02452, USA
    J Neurobiol 66:780-91. 2006
  4. ncbi Macrocephaly and the control of brain growth in autistic disorders
    Peter McCaffery
    UMMS EK Shriver Center, 200 Trapelo Road, Waltham, MA, USA
    Prog Neurobiol 77:38-56. 2005
  5. ncbi Retinoic acid influences neuronal migration from the ganglionic eminence to the cerebral cortex
    James E Crandall
    Eunice Kennedy Shriver Center for Mental Retardation, University of Massachusetts Medical School, Waltham, Massachusetts, USA
    J Neurochem 119:723-35. 2011
  6. ncbi 13-cis Retinoic acid (accutane) suppresses hippocampal cell survival in mice
    Yasuo Sakai
    UMMS/E.K. Shriver Center, 200 Trapelo Rd, Waltham, MA 02452, USA
    Ann N Y Acad Sci 1021:436-40. 2004
  7. ncbi CYP26A1 and CYP26C1 cooperate in degrading retinoic acid within the equatorial retina during later eye development
    Yasuo Sakai
    Eunice Kennedy Shriver Center at the University of Massachusetts Medical School, Waltham, MA, USA
    Dev Biol 276:143-57. 2004
  8. ncbi Ethanol increases retinoic acid production in cerebellar astrocytes and in cerebellum
    Peter McCaffery
    University of Massachusetts Medical School Shriver Center, Waltham, MA, USA
    Brain Res Dev Brain Res 153:233-41. 2004
  9. ncbi Developmental expression of receptor for advanced glycation end products (RAGE), amphoterin and sulfoglucuronyl (HNK-1) carbohydrate in mouse cerebellum and their role in neurite outgrowth and cell migration
    Denise K H Chou
    Department of Neurobiology, E K Shriver Center at University of Massachusetts Medical School, Waltham, Massachusetts 02452, USA
    J Neurochem 90:1389-401. 2004
  10. ncbi 13-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice
    James Crandall
    E. K. Shriver Center, University of Massachusetts Medical School, Waltham, MA 02452, USA
    Proc Natl Acad Sci U S A 101:5111-6. 2004

Research Grants

  1. Hippocampal Neurogenesis and Accutane Induced Depression
    Peter McCaffery; Fiscal Year: 2003

Collaborators

  • Hiroshi Hamada
  • M Maden
  • Athena Andreadis
  • J Adams
  • Stefan Stamm
  • Frances I Smith
  • Jörg Mey
  • WIM CRUSIO
  • J Douglas Bremner
  • Yasuo Sakai
  • Jinghua Zhang
  • James E Crandall
  • Miyuki Yamamoto
  • Cristoforo Silvestri
  • Nicole Spiegl
  • URSULA C DRAGER
  • Sze Wah Tse
  • Denise K H Chou
  • Deborah Smith
  • James Crandall
  • Nina Zhelyaznik
  • Deirdre M McCarthy
  • Gregg Duester
  • Pradeep G Bhide
  • Timothy Goodman
  • Nicholas B J Tan
  • Liliana Attisano
  • Ingo Von Both
  • Clemens A Dahinden
  • Luisa Izzi
  • Jeffrey L Wrana
  • Hanno Langen
  • Yongmei Liu
  • Svetlana Didichenko
  • Masahiro Narimatsu
  • Margaret Clagett-Dame
  • Mei Ling Wei
  • Min Hua Luo
  • Yoshika Hayakawa
  • Sze-Wah Tse
  • Mei-Ling Wei
  • Shinji Hirano
  • Jennifer A Broderick
  • Masahiro Fujinuma
  • Min-Hua Luo
  • Yann Mineur
  • Omanand Koul
  • Jacob Brodsky
  • Firoze B Jungalwala
  • Tuanlian Luo
  • Kirsten Schrage
  • Lanhua Ma

Detail Information

Publications19

  1. ncbi Retinoid quantification by HPLC/MS(n)
    Peter McCaffery
    University of Massachusetts, E K Shriver Center, Waltham, MA, USA
    J Lipid Res 43:1143-9. 2002
    ..The all-trans, 9-cis, and 13-cis RA isomers are separated, if desired, by an isocratic hexane-dioxane-isopropanol mobile phase. This paper describes an HPLC/MS(n) procedure possessing high sensitivity and specificity for retinoids...
  2. ncbi Too much of a good thing: retinoic acid as an endogenous regulator of neural differentiation and exogenous teratogen
    P J McCaffery
    UMMS E K Shriver Center, Waltham, MA USA
    Eur J Neurosci 18:457-72. 2003
    ..This report shows how the properties of RA as a neural induction agent and organizer of segmentation can explain the consequences of RA depletion and overexpression...
  3. ncbi Retinoic acid signaling and function in the adult hippocampus
    Peter McCaffery
    UMMS E K Shriver Center, Waltham, Massachusetts 02452, USA
    J Neurobiol 66:780-91. 2006
    ..The hippocampus is a brain region dependent upon neural plasticity for its function in learning and memory, and this review focuses on the roles that RA may play in regulating these processes in the adult...
  4. ncbi Macrocephaly and the control of brain growth in autistic disorders
    Peter McCaffery
    UMMS EK Shriver Center, 200 Trapelo Road, Waltham, MA, USA
    Prog Neurobiol 77:38-56. 2005
    ..We review factors known to control these processes with an emphasis on nuclear receptor activation as one signaling control that may be abnormal and contribute to increased brain volume in autistic disorders...
  5. ncbi Retinoic acid influences neuronal migration from the ganglionic eminence to the cerebral cortex
    James E Crandall
    Eunice Kennedy Shriver Center for Mental Retardation, University of Massachusetts Medical School, Waltham, Massachusetts, USA
    J Neurochem 119:723-35. 2011
    ..These observations suggest functions of retinoic acid in interneuron diversity and organization of cortical excitatory-inhibitory balance...
  6. ncbi 13-cis Retinoic acid (accutane) suppresses hippocampal cell survival in mice
    Yasuo Sakai
    UMMS/E.K. Shriver Center, 200 Trapelo Rd, Waltham, MA 02452, USA
    Ann N Y Acad Sci 1021:436-40. 2004
    ..In humans this may be conjectured to be the mechanism by which Accutane contributes to depression...
  7. ncbi CYP26A1 and CYP26C1 cooperate in degrading retinoic acid within the equatorial retina during later eye development
    Yasuo Sakai
    Eunice Kennedy Shriver Center at the University of Massachusetts Medical School, Waltham, MA, USA
    Dev Biol 276:143-57. 2004
    ..The safeguard of the RA-poor stripe by two distinct enzymes during later development points to a role in maturation of a significant functional feature like an area of higher visual acuity that develops at its location...
  8. ncbi Ethanol increases retinoic acid production in cerebellar astrocytes and in cerebellum
    Peter McCaffery
    University of Massachusetts Medical School Shriver Center, Waltham, MA, USA
    Brain Res Dev Brain Res 153:233-41. 2004
    ..Cerebellar RA levels climbed significantly after such treatment. These results suggest that the cerebellar pathology exerted by ethanol may occur, at least in part, through increased production of RA...
  9. ncbi Developmental expression of receptor for advanced glycation end products (RAGE), amphoterin and sulfoglucuronyl (HNK-1) carbohydrate in mouse cerebellum and their role in neurite outgrowth and cell migration
    Denise K H Chou
    Department of Neurobiology, E K Shriver Center at University of Massachusetts Medical School, Waltham, Massachusetts 02452, USA
    J Neurochem 90:1389-401. 2004
    ..The results suggest that RAGE could act as a signaling molecule for neurite outgrowth and cell migration by its interaction with Amphoterin and that of Amphoterin with SGC...
  10. ncbi 13-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in mice
    James Crandall
    E. K. Shriver Center, University of Massachusetts Medical School, Waltham, MA 02452, USA
    Proc Natl Acad Sci U S A 101:5111-6. 2004
    ..The results demonstrate that the regions of the adult brain where cell proliferation is ongoing are highly sensitive to disruption by a clinical dose of 13-cis-RA...
  11. ncbi The meninges is a source of retinoic acid for the late-developing hindbrain
    Jinghua Zhang
    E Kennedy Shriver Center, University of Massachusetts Medical School, University of Massachusetts, Waltham, Massachusetts 02452, USA
    J Neurosci 23:7610-20. 2003
    ....
  12. ncbi Identification, expression analysis, genomic organization and cellular location of a novel protein with a RhoGEF domain
    Sze Wah Tse
    Department of Biomedical Sciences, E K Shriver Center for Mental Retardation, Waltham, MA 02452, USA
    Gene 359:63-72. 2005
    ..In both myoblasts and neuroblastoma cells, the Solo protein is concentrated around the nucleus...
  13. ncbi Retinoic acid influences the development of the inferior olivary nucleus in the rodent
    Miyuki Yamamoto
    Inst Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Dev Biol 280:421-33. 2005
    ..In support of this concept, a reduction in atRA resulting from vitamin A deficiency results in loss of cells of the posterior inferior olive...
  14. ncbi Retinoic acid synthesis by a population of NG2-positive cells in the injured spinal cord
    Jörg Mey
    Institute of Biology II, RWTH Aachen, Germany
    Eur J Neurosci 21:1555-68. 2005
    ..These findings indicate that close correlations exist between RA synthesis and SCI and that RA may play a role in the secondary events that follow acute SCI...
  15. ncbi Retinoic acid signaling in the nervous system of adult vertebrates
    Jörg Mey
    Institut fur Biologie II, Aachen, Germany
    Neuroscientist 10:409-21. 2004
    ....
  16. ncbi Activation of retinoic acid signalling after sciatic nerve injury: up-regulation of cellular retinoid binding proteins
    Nina Zhelyaznik
    , RWTH Aachen, Kopernikusstr 16, 52074 Aachen, Germany
    Eur J Neurosci 18:1033-40. 2003
    ..Both kinds of injury also caused a 15-fold increase in transcript and protein concentration of CRABP-II, a possible mediator of RA transfer to its nuclear receptors...
  17. ncbi The neurobiology of retinoic acid in affective disorders
    J Douglas Bremner
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30306, USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:315-31. 2008
    ..This report reviews the evidence in this area and describes several systems that may be targets of retinoic acid and which contribute to the pathophysiology of depression...
  18. ncbi Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development
    Cristoforo Silvestri
    Institute of Medical Science, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada
    Dev Cell 14:411-23. 2008
    ..Integrated mapping of a developmental transcription factor network thus reveals a key role for Foxh1 in patterning and initiating RA signaling in the forebrain...
  19. ncbi Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid
    Nicole Spiegl
    Institute of Immunology, University Hospital Bern, Inselspital, Bern, Switzerland
    Blood 112:3762-71. 2008
    ..Thus, RA must be viewed as a tightly controlled basophil-derived mediator with a high potential for regulating diverse functions of immune and resident cells in allergic diseases and other Th2-type immune responses...

Research Grants1

  1. Hippocampal Neurogenesis and Accutane Induced Depression
    Peter McCaffery; Fiscal Year: 2003
    ..abstract_text> ..