Genomes and Genes
Affiliation: University of Massachusetts Medical School
- Retinoid quantification by HPLC/MS(n)Peter McCaffery
University of Massachusetts, E K Shriver Center, Waltham, MA, USA
J Lipid Res 43:1143-9. 2002..The all-trans, 9-cis, and 13-cis RA isomers are separated, if desired, by an isocratic hexane-dioxane-isopropanol mobile phase. This paper describes an HPLC/MS(n) procedure possessing high sensitivity and specificity for retinoids...
- Too much of a good thing: retinoic acid as an endogenous regulator of neural differentiation and exogenous teratogenP J McCaffery
UMMS E K Shriver Center, Waltham, MA USA
Eur J Neurosci 18:457-72. 2003..This report shows how the properties of RA as a neural induction agent and organizer of segmentation can explain the consequences of RA depletion and overexpression...
- Retinoic acid signaling and function in the adult hippocampusPeter McCaffery
UMMS E K Shriver Center, Waltham, Massachusetts 02452, USA
J Neurobiol 66:780-91. 2006..The hippocampus is a brain region dependent upon neural plasticity for its function in learning and memory, and this review focuses on the roles that RA may play in regulating these processes in the adult...
- Macrocephaly and the control of brain growth in autistic disordersPeter McCaffery
UMMS EK Shriver Center, 200 Trapelo Road, Waltham, MA, USA
Prog Neurobiol 77:38-56. 2005..We review factors known to control these processes with an emphasis on nuclear receptor activation as one signaling control that may be abnormal and contribute to increased brain volume in autistic disorders...
- Retinoic acid influences neuronal migration from the ganglionic eminence to the cerebral cortexJames E Crandall
Eunice Kennedy Shriver Center for Mental Retardation, University of Massachusetts Medical School, Waltham, Massachusetts, USA
J Neurochem 119:723-35. 2011..These observations suggest functions of retinoic acid in interneuron diversity and organization of cortical excitatory-inhibitory balance...
- 13-cis Retinoic acid (accutane) suppresses hippocampal cell survival in miceYasuo Sakai
UMMS/E.K. Shriver Center, 200 Trapelo Rd, Waltham, MA 02452, USA
Ann N Y Acad Sci 1021:436-40. 2004..In humans this may be conjectured to be the mechanism by which Accutane contributes to depression...
- CYP26A1 and CYP26C1 cooperate in degrading retinoic acid within the equatorial retina during later eye developmentYasuo Sakai
Eunice Kennedy Shriver Center at the University of Massachusetts Medical School, Waltham, MA, USA
Dev Biol 276:143-57. 2004..The safeguard of the RA-poor stripe by two distinct enzymes during later development points to a role in maturation of a significant functional feature like an area of higher visual acuity that develops at its location...
- Ethanol increases retinoic acid production in cerebellar astrocytes and in cerebellumPeter McCaffery
University of Massachusetts Medical School Shriver Center, Waltham, MA, USA
Brain Res Dev Brain Res 153:233-41. 2004..Cerebellar RA levels climbed significantly after such treatment. These results suggest that the cerebellar pathology exerted by ethanol may occur, at least in part, through increased production of RA...
- Developmental expression of receptor for advanced glycation end products (RAGE), amphoterin and sulfoglucuronyl (HNK-1) carbohydrate in mouse cerebellum and their role in neurite outgrowth and cell migrationDenise K H Chou
Department of Neurobiology, E K Shriver Center at University of Massachusetts Medical School, Waltham, Massachusetts 02452, USA
J Neurochem 90:1389-401. 2004..The results suggest that RAGE could act as a signaling molecule for neurite outgrowth and cell migration by its interaction with Amphoterin and that of Amphoterin with SGC...
- 13-cis-retinoic acid suppresses hippocampal cell division and hippocampal-dependent learning in miceJames Crandall
E. K. Shriver Center, University of Massachusetts Medical School, Waltham, MA 02452, USA
Proc Natl Acad Sci U S A 101:5111-6. 2004..The results demonstrate that the regions of the adult brain where cell proliferation is ongoing are highly sensitive to disruption by a clinical dose of 13-cis-RA...
- The meninges is a source of retinoic acid for the late-developing hindbrainJinghua Zhang
E Kennedy Shriver Center, University of Massachusetts Medical School, University of Massachusetts, Waltham, Massachusetts 02452, USA
J Neurosci 23:7610-20. 2003....
- Identification, expression analysis, genomic organization and cellular location of a novel protein with a RhoGEF domainSze Wah Tse
Department of Biomedical Sciences, E K Shriver Center for Mental Retardation, Waltham, MA 02452, USA
Gene 359:63-72. 2005..In both myoblasts and neuroblastoma cells, the Solo protein is concentrated around the nucleus...
- Retinoic acid influences the development of the inferior olivary nucleus in the rodentMiyuki Yamamoto
Inst Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan
Dev Biol 280:421-33. 2005..In support of this concept, a reduction in atRA resulting from vitamin A deficiency results in loss of cells of the posterior inferior olive...
- Retinoic acid synthesis by a population of NG2-positive cells in the injured spinal cordJörg Mey
Institute of Biology II, RWTH Aachen, Germany
Eur J Neurosci 21:1555-68. 2005..These findings indicate that close correlations exist between RA synthesis and SCI and that RA may play a role in the secondary events that follow acute SCI...
- Retinoic acid signaling in the nervous system of adult vertebratesJörg Mey
Institut fur Biologie II, Aachen, Germany
Neuroscientist 10:409-21. 2004....
- Activation of retinoic acid signalling after sciatic nerve injury: up-regulation of cellular retinoid binding proteinsNina Zhelyaznik
, RWTH Aachen, Kopernikusstr 16, 52074 Aachen, Germany
Eur J Neurosci 18:1033-40. 2003..Both kinds of injury also caused a 15-fold increase in transcript and protein concentration of CRABP-II, a possible mediator of RA transfer to its nuclear receptors...
- The neurobiology of retinoic acid in affective disordersJ Douglas Bremner
Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30306, USA
Prog Neuropsychopharmacol Biol Psychiatry 32:315-31. 2008..This report reviews the evidence in this area and describes several systems that may be targets of retinoic acid and which contribute to the pathophysiology of depression...
- Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain developmentCristoforo Silvestri
Institute of Medical Science, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada
Dev Cell 14:411-23. 2008..Integrated mapping of a developmental transcription factor network thus reveals a key role for Foxh1 in patterning and initiating RA signaling in the forebrain...
- Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acidNicole Spiegl
Institute of Immunology, University Hospital Bern, Inselspital, Bern, Switzerland
Blood 112:3762-71. 2008..Thus, RA must be viewed as a tightly controlled basophil-derived mediator with a high potential for regulating diverse functions of immune and resident cells in allergic diseases and other Th2-type immune responses...
- Hippocampal Neurogenesis and Accutane Induced DepressionPeter McCaffery; Fiscal Year: 2003..abstract_text> ..