Katelyn E McCabe
Affiliation: University of California
- An engineered cysteine-modified diabody for imaging activated leukocyte cell adhesion molecule (ALCAM)-positive tumorsKatelyn E McCabe
Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA
Mol Imaging Biol 14:336-47. 2012..The purpose of this study was to generate and evaluate a positron emission tomography (PET) radiotracer targeting activated leukocyte cell adhesion molecule (ALCAM)...
- Anti-CA19-9 diabody as a PET imaging probe for pancreas cancerMark D Girgis
Department of Surgery, UCLA, Los Angeles, California 90095, USA
J Surg Res 170:169-78. 2011..Our goal was to develop and characterize the anti-CA19-9 diabody fragment and determine its ability to provide antigen specific imaging of pancreas cancer...
- An engineered anti-CA19-9 cys-diabody for positron emission tomography imaging of pancreatic cancer and targeting of polymerized liposomal nanoparticlesMark D Girgis
Department of Surgery, Veterans Healthcare Affairs, Greater Los Angeles, Los Angeles, California Department of Surgery, UCLA, Los Angeles, California
J Surg Res 185:45-55. 2013..The goal of this study was to engineer an anti-carbohydrate antigen 19-9 (CA19-9) cys-diabody fragment in hopes of targeting nanoparticles to pancreatic cancer...
- Targeting CEA in Pancreas Cancer Xenografts with a Mutated scFv-Fc Antibody FragmentMark D Girgis
Department of Surgery, UCLA, 10833 LeConte Ave, Rm 54 140, Los Angeles, CA 90095, USA
EJNMMI Res 1:24. 2011..abstract:..
- Positive progress in immunoPET--not just a coincidenceKatelyn E McCabe
David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Cancer Biother Radiopharm 25:253-61. 2010..Antibody-based PET probes constitute a valuable class of molecular imaging agents, and the progress made preclinically should expedite the transition of these targeted diagnostics to clinical applications...
- CA19-9 as a Potential Target for Radiolabeled Antibody-Based Positron Emission Tomography of Pancreas CancerMark D Girgis
Department of Surgery, UCLA, 10833 LeConte Avenue, Rm 54 140, Los Angeles, CA 90095, USA
Int J Mol Imaging 2011:834515. 2011..Conclusion. We show in vivo targeting of our antigen positive xenograft with a radiolabeled anti-CA19-9 antibody. These data demonstrate the potential to achieve anti-CA19-9 antibody based positron emission tomography of pancreas cancer...
- An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumorsEric J Lepin
Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
Eur J Nucl Med Mol Imaging 37:1529-38. 2010..However, the humanization and antibody fragment reformatting decreased its apparent affinity. Here, we sought to evaluate PET imaging contrast with affinity matured minibodies...