Theodore Mazzone

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc Relation of abdominal fat depots to systemic markers of inflammation in type 2 diabetes
    Susan Sam
    Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA
    Diabetes Care 32:932-7. 2009
  2. ncbi request reprint Prevention of macrovascular disease in patients with diabetes mellitus: opportunities for intervention
    Theodore Mazzone
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Am J Med 120:S26-32. 2007
  3. ncbi request reprint Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: a randomized trial
    Theodore Mazzone
    Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, University of Illinois College of Medicine, Chicago 60612, USA
    JAMA 296:2572-81. 2006
  4. ncbi request reprint Reducing cardiovascular disease in patients with diabetes mellitus
    Theodore Mazzone
    Section of Diabetes and Metabolism, University of Illinois at Chicago, Chicago, IL 60612, USA
    Curr Opin Cardiol 20:245-9. 2005
  5. ncbi request reprint Relationship of traditional and nontraditional cardiovascular risk factors to coronary artery calcium in type 2 diabetes
    Theodore Mazzone
    Section of Diabetes and Metabolism MC 797, University of Illinois at Chicago, 1819 W Polk Street, Chicago, IL 60612, USA
    Diabetes 56:849-55. 2007
  6. ncbi request reprint Strategies in ongoing clinical trials to reduce cardiovascular disease in patients with diabetes mellitus and insulin resistance
    Theodore Mazzone
    Department of Medicine, University of Illinois, Chicago, Illinois, USA
    Am J Cardiol 93:27C-31C. 2004
  7. ncbi request reprint The role of electron beam computed tomography for measuring coronary artery atherosclerosis
    Theodore Mazzone
    Department of Medicine, Section of Diabetes and Metabolism MC 797, University of Illinois, 1819 W Polk Street, Chicago, IL 60612, USA
    Curr Diab Rep 4:20-5. 2004
  8. ncbi request reprint HDL cholesterol and atherosclerosis
    Theodore Mazzone
    University of Illinois at Chicago, 1819 W Polk Street, Chicago, IL 61612, USA
    Lancet 370:107-8. 2007
  9. ncbi request reprint Adipose tissue and the vessel wall
    Theodore Mazzone
    University of Illinois at Chicago, Chicago, Illinois, USA
    Curr Drug Targets 8:1190-5. 2007
  10. pmc Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies
    Theodore Mazzone
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Lancet 371:1800-9. 2008

Research Grants

  1. Adipocyte Lipid Metabolism and ApoE Expression
    Theodore Mazzone; Fiscal Year: 2009
  2. CELL SURFACE METABOLISM OF MACROPHAGE DERIVED APO E
    Theodore Mazzone; Fiscal Year: 2001
  3. MACROPHAGE CHOLESTEROL METABOLISM AND APO E SYNTHESIS
    Theodore Mazzone; Fiscal Year: 2000
  4. Macrophage Cholesterol Metabolism and ApoE Synthesis
    Theodore Mazzone; Fiscal Year: 2007
  5. Macrophage Cholesterol Metabolism and ApoE Synthesis
    Theodore Mazzone; Fiscal Year: 2005
  6. MACROPHAGE CHOLESTEROL METABOLISM AND APO E SYNTHESIS
    Theodore Mazzone; Fiscal Year: 2001
  7. CELL SURFACE METABOLISM OF MACROPHAGE DERIVED APO E
    Theodore Mazzone; Fiscal Year: 2000
  8. CELL SURFACE METABOLISM OF MACROPHAGE DERIVED APO E
    Theodore Mazzone; Fiscal Year: 1999
  9. MACROPHAGE CHOLESTEROL METABOLISM AND APO-E SYNTHESIS
    Theodore Mazzone; Fiscal Year: 1993
  10. Adipocyte Lipid Metabolism and ApoE Expression
    Theodore Mazzone; Fiscal Year: 2008

Collaborators

Detail Information

Publications60

  1. pmc Relation of abdominal fat depots to systemic markers of inflammation in type 2 diabetes
    Susan Sam
    Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism, University of Illinois at Chicago, Chicago, Illinois, USA
    Diabetes Care 32:932-7. 2009
    ..We examined the relationships between VAT and SAT and systemic inflammatory markers in a large well-characterized cohort of subjects with type 2 diabetes...
  2. ncbi request reprint Prevention of macrovascular disease in patients with diabetes mellitus: opportunities for intervention
    Theodore Mazzone
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Am J Med 120:S26-32. 2007
    ..Addition of pioglitazone to existing therapy in high-risk patients with diabetes and atherosclerotic disease improves cardiovascular outcomes, and may be particularly beneficial for patients with previous myocardial infarction or stroke...
  3. ncbi request reprint Effect of pioglitazone compared with glimepiride on carotid intima-media thickness in type 2 diabetes: a randomized trial
    Theodore Mazzone
    Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, University of Illinois College of Medicine, Chicago 60612, USA
    JAMA 296:2572-81. 2006
    ..While studies of relatively short duration have suggested that thiazolidinediones such as pioglitazone might reduce progression of CIMT in persons with diabetes, the results of longer studies have been less clear...
  4. ncbi request reprint Reducing cardiovascular disease in patients with diabetes mellitus
    Theodore Mazzone
    Section of Diabetes and Metabolism, University of Illinois at Chicago, Chicago, IL 60612, USA
    Curr Opin Cardiol 20:245-9. 2005
    ....
  5. ncbi request reprint Relationship of traditional and nontraditional cardiovascular risk factors to coronary artery calcium in type 2 diabetes
    Theodore Mazzone
    Section of Diabetes and Metabolism MC 797, University of Illinois at Chicago, 1819 W Polk Street, Chicago, IL 60612, USA
    Diabetes 56:849-55. 2007
    ..Adiposity measures are significantly associated with coronary artery calcium score, but their importance may be largely explained by apolipoprotein B or triglyceride-rich lipoprotein cholesterol...
  6. ncbi request reprint Strategies in ongoing clinical trials to reduce cardiovascular disease in patients with diabetes mellitus and insulin resistance
    Theodore Mazzone
    Department of Medicine, University of Illinois, Chicago, Illinois, USA
    Am J Cardiol 93:27C-31C. 2004
    ..Most of these trials will report their findings in the next 5 years. It is likely that the results of ongoing trials will significantly improve our approach to managing cardiovascular risk in patients with diabetes and IGT...
  7. ncbi request reprint The role of electron beam computed tomography for measuring coronary artery atherosclerosis
    Theodore Mazzone
    Department of Medicine, Section of Diabetes and Metabolism MC 797, University of Illinois, 1819 W Polk Street, Chicago, IL 60612, USA
    Curr Diab Rep 4:20-5. 2004
    ..However, measurement of coronary artery calcium may be valuable in selected clinical situations, and has potential as a research tool for studying the pathogenesis or treatment of stable coronary artery disease...
  8. ncbi request reprint HDL cholesterol and atherosclerosis
    Theodore Mazzone
    University of Illinois at Chicago, 1819 W Polk Street, Chicago, IL 61612, USA
    Lancet 370:107-8. 2007
  9. ncbi request reprint Adipose tissue and the vessel wall
    Theodore Mazzone
    University of Illinois at Chicago, Chicago, Illinois, USA
    Curr Drug Targets 8:1190-5. 2007
    ..The power of mouse genetics permits targeted mechanistic investigation for understanding how obesity accelerates atherosclerosis in a complex in vivo milieu...
  10. pmc Cardiovascular disease risk in type 2 diabetes mellitus: insights from mechanistic studies
    Theodore Mazzone
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Lancet 371:1800-9. 2008
    ....
  11. pmc Hyperglycemia and advanced glycosylation end products suppress adipocyte apoE expression: implications for adipocyte triglyceride metabolism
    Doris Joy Espiritu
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Am J Physiol Endocrinol Metab 299:E615-23. 2010
    ..In vivo results using adipose tissue transplantation suggest that reduction of adipocyte apoE, and subsequent reduction of adipocyte triglyceride accumulation, could influence lipid accumulation in nonadipose tissue...
  12. doi request reprint Increased high-density lipoprotein cholesterol predicts the pioglitazone-mediated reduction of carotid intima-media thickness progression in patients with type 2 diabetes mellitus
    Michael Davidson
    Pritzker School of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Circulation 117:2123-30. 2008
    ..Compared with glimepiride, pioglitazone has been shown to slow the progression of atherosclerosis measured by CIMT in patients with type 2 diabetes mellitus...
  13. pmc Relationship of abdominal visceral and subcutaneous adipose tissue with lipoprotein particle number and size in type 2 diabetes
    Susan Sam
    Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, Chicago, Illinois, USA
    Diabetes 57:2022-7. 2008
    ..Insulin resistance and type 2 diabetes are associated with an atherogenic lipoprotein profile. We examined the role of visceral and subcutaneous fat depots, independent of BMI, on the dyslipidemia associated with type 2 diabetes...
  14. pmc Peroxisome proliferator-activated receptor {gamma} stimulation of adipocyte ApoE gene transcription mediated by the liver receptor X pathway
    Lili Yue
    Departments of Medicine, Pharmacology, and Human Nutrition, University of Illinois, Chicago, Illinois 60612
    J Biol Chem 284:10453-61. 2009
    ..The current observations suggest that the PPARgamma-LXR-apoE regulatory cascade could be an important molecular link for cross-talk between adipocyte triglyceride and cholesterol homeostasis...
  15. pmc Pioglitazone versus glimepiride on coronary artery calcium progression in patients with type 2 diabetes mellitus: a secondary end point of the CHICAGO study
    Michael H Davidson
    Department of Medicine, Division of Cardiology, Pritzker School of Medicine, The University of Chicago, 515 N State St, Ste 2700, Chicago, IL 60654, USA
    Arterioscler Thromb Vasc Biol 30:1873-6. 2010
    ..To compare coronary artery calcium (CAC) progression between 2 treatment groups, pioglitazone versus glimepiride...
  16. pmc Mechanism for endogenously expressed ApoE modulation of adipocyte very low density lipoprotein metabolism: role in endocytic and lipase-mediated metabolic pathways
    Zhi Hua Huang
    Department of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 284:31512-22. 2009
    ..Reduced adipocyte apoE expression, for example that accompanying obesity, will suppress adipocyte acquisition of lipid from apoE-containing VLDL...
  17. pmc ApoE derived from adipose tissue does not suppress atherosclerosis or correct hyperlipidemia in apoE knockout mice
    Zhi H Huang
    Department of Medicine, University of Chicago, Chicago, IL, USA
    J Lipid Res 54:202-13. 2013
    ..A potential mechanism contributing to this difference is differential binding to cell surface lipoprotein receptors...
  18. ncbi request reprint Nutritional regulation of adipose tissue apolipoprotein E expression
    Zhi Hua Huang
    Section of Endocrinology, Diabetes and Metabolism MC 797, University of Illinois at Chicago, 1819 W Polk St, Chicago, IL 60612, USA
    Am J Physiol Endocrinol Metab 293:E203-9. 2007
    ..Furthermore, these results suggest adipose tissue apoE participates in defending adipose tissue and organismal energy homeostasis in response to nutritional perturbation...
  19. doi request reprint The clinical implications of the CHICAGO study for the management of cardiovascular risk in patients with type 2 diabetes mellitus
    Tamar Polonsky
    Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA
    Trends Cardiovasc Med 19:94-9. 2009
    ..The following review examines data from additional studies evaluating how pioglitazone and HDL levels modify cardiovascular risk...
  20. pmc PCOS is associated with increased CD11c expression and crown-like structures in adipose tissue and increased central abdominal fat depots independent of obesity
    Zhi Hua Huang
    Department of Medicine, Section of Endocrinology, Diabetes, and Metabolism MC 797, University of Illinois at Chicago, 1819 West Polk Street, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 98:E17-24. 2013
    ..Adipose tissue macrophage (ATM) infiltration is a major pathway for obesity-induced insulin resistance but has not been studied as a mechanism for insulin resistance in PCOS...
  21. pmc Risk of obstructive sleep apnea in obese and nonobese women with polycystic ovary syndrome and healthy reproductively normal women
    Babak Mokhlesi
    Sleep Disorders Center, Section of Pulmonary and Critical Care, Department of Medicine, University of Chicago, Chicago, Illinois 60612, USA
    Fertil Steril 97:786-91. 2012
    ..To study the risk for obstructive sleep apnea (OSA) in a group of nonobese and obese polycystic ovary syndrome (PCOS) and control women...
  22. pmc Pioglitazone-mediated changes in lipoprotein particle composition are predicted by changes in adiponectin level in type 2 diabetes
    Susan Sam
    Department of Medicine, University of Illinois at Chicago, 1819 West Polk Street, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 97:E110-4. 2012
    ..In animal and observational studies, adiponectin is associated with lipoprotein risk factors for cardiovascular disease...
  23. pmc Role of adipocyte-derived apoE in modulating adipocyte size, lipid metabolism, and gene expression in vivo
    Zhi Hua Huang
    Department of Medicine, University of Illinois, Chicago, IL 60612, USA
    Am J Physiol Endocrinol Metab 296:E1110-9. 2009
    ..They support a model in which endogenously produced adipocyte apoE facilitates adipocyte lipid acquisition from circulating TG-rich lipoproteins...
  24. pmc Hypertriglyceridemic waist phenotype predicts increased visceral fat in subjects with type 2 diabetes
    Susan Sam
    Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, University of Illinois, Chicago, Illinois
    Diabetes Care 32:1916-20. 2009
    ..Greater accumulation of visceral fat is strongly linked to risk of cardiovascular disease. However, elevated waist circumference by itself does not always identify individuals with increased visceral fat...
  25. ncbi request reprint Endogenous ApoE expression modulates adipocyte triglyceride content and turnover
    Zhi Hua Huang
    Section of Endocrinology, Diabetes and Metabolism MC 797, University of Illinois, 1819 W Polk St, Chicago, IL 60612, USA
    Diabetes 55:3394-402. 2006
    ..These results establish a novel role for endogenous apoE in adipocyte lipid metabolism and have implications for constructing an integrated model of adipocyte physiology in health and disease...
  26. pmc Oxidative stress regulates adipocyte apolipoprotein e and suppresses its expression in obesity
    Doris Joy Espiritu
    Department of Medicine, University of Illinois, Chicago, Illinois, USA
    Diabetes 57:2992-8. 2008
    ..Adipose tissue oxidant stress is emerging as an important mediator of adipocyte dysfunction. These studies were undertaken to evaluate the role of oxidant stress for regulation of adipocyte apoE...
  27. pmc Adipose tissue depot-specific differences in adipocyte apolipoprotein E expression
    Zhi H Huang
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Metabolism 60:1692-701. 2011
    ..Because of its role in modulating adipocyte triglyceride and lipoprotein metabolism, depot-specific differences in endogenous adipocyte apoE could have important implications for modulating the accumulation of lipid in these depots...
  28. pmc Expression of the human apoE2 isoform in adipocytes: altered cellular processing and impaired adipocyte lipogenesis
    Zhi H Huang
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    J Lipid Res 52:1733-41. 2011
    ..These changes recapitulate those observed in apoE knockout adipocytes and have implications for understanding metabolic disturbances in humans expressing the E2 isoform...
  29. pmc Tumor necrosis factor-alpha-mediated suppression of adipocyte apolipoprotein E gene transcription: primary role for the nuclear factor (NF)-kappaB pathway and NFkappaB p50
    Lili Yue
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Endocrinology 149:4051-8. 2008
    ..The suppression of adipocyte apoE by the proinflammatory adipose tissue milieu associated with obesity will have important downstream effects on adipocyte triglyceride turnover and content...
  30. pmc The role of oxysterols in control of endothelial stiffness
    Tzu Pin Shentu
    Pulmonary, Critical Care, and Sleep Medicine, University of Illinois, Chicago, IL 60612, USA
    J Lipid Res 53:1348-58. 2012
    ..Remarkably, these are the same oxysterols we have identified to induce endothelial stiffening...
  31. ncbi request reprint Identification of stem cells from human umbilical cord blood with embryonic and hematopoietic characteristics
    Yong Zhao
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, IL 60612, USA
    Exp Cell Res 312:2454-64. 2006
    ..These findings may have significant potential to advance stem-cell-based therapeutics...
  32. pmc Apolipoprotein E enhances endothelial-NO production by modulating caveolin 1 interaction with endothelial NO synthase
    Lili Yue
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    Hypertension 60:1040-6. 2012
    ..We conclude that macrophage-derived apoE enhances endothelial NO production by disrupting the inhibitory interaction of eNOS with cav-1. These results establish a novel mechanism by which apoE modulates endothelial cell function...
  33. ncbi request reprint Type 2 diabetes, glycemic control, and continuous positive airway pressure in obstructive sleep apnea
    Ambika R Babu
    Department of Medicine, Rush University Medical Center, Chicago, IL 60612, USA
    Arch Intern Med 165:447-52. 2005
    ..It has been previously shown that the severity of insulin resistance is related to the severity of SDB...
  34. ncbi request reprint Adipose tissue and atherosclerosis: exploring the connection
    Giamila Fantuzzi
    Department of Human Nutrition, University of Illinois at Chicago, USA
    Arterioscler Thromb Vasc Biol 27:996-1003. 2007
    ..The unfolding role of adipose tissue as an important metabolic and secretory organ provides new opportunities for developing more effective approaches for preventing obesity and its atherosclerotic complications...
  35. pmc Endogenous adipocyte apolipoprotein E is colocalized with caveolin at the adipocyte plasma membrane
    Lili Yue
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Lipid Res 52:489-98. 2011
    ....
  36. ncbi request reprint Regulation of macrophage apoE secretion and sterol efflux by the LDL receptor
    Danijela Lucic
    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
    J Lipid Res 48:366-72. 2007
    ..These results establish a regulatory interaction between two branches of macrophage sterol homeostatic pathways that could facilitate a rapid response to changes in macrophage sterol content relative to need...
  37. ncbi request reprint Effects of fenofibric acid on carotid intima-media thickness in patients with mixed dyslipidemia on atorvastatin therapy: randomized, placebo-controlled study (FIRST)
    Michael H Davidson
    From the Department of Medicine, University of Chicago, IL M H D Icahn School of Medicine at Mount Sinai, New York, NY R S R Biofortis Clinical Research, Addison, IL K C M Cardiology, University of Adelaide, Adelaide, Australia S J N Consultant Cardiologist, Royal Adelaide Hospital, Adelaide, Australia S J N Section of Cardiology, Section of Atherosclerosis and Vascular Medicine, and Center for Cardiovascular Disease Prevention, Methodist DeBakey Heart Center, Houston, TX C M B the Maria and Alando J Ballantyne, MD, Atherosclerosis Laboratory, and Lipid Metabolism and Atherosclerosis Clinic, The Methodist Hospital, Houston, TX C M B Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago T M and Global Pharmaceutical Research and Development D M C, L A W, M T K, H S C, J C S, and Data and Statistical Sciences A L, AbbVie Inc, North Chicago, IL
    Arterioscler Thromb Vasc Biol 34:1298-306. 2014
    ....
  38. ncbi request reprint Cellular sphingolipids regulate macrophage apolipoprotein E secretion
    Danijela Lucic
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Biochemistry 46:11196-204. 2007
    ..The dependence for this effect on the C-terminal domain of apoE suggests a model in which the SM content of intracellular membranes modulates the secretion of nascent apoE via the interaction with amphipathic lipid-binding domains...
  39. ncbi request reprint Angiotensin II regulates adipocyte apolipoprotein E expression
    Poornima Rao
    Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 92:4366-72. 2007
    ..Recently, endogenous expression of apolipoprotein E (apoE) in adipose tissue has been shown to have important effects on adipocyte lipid flux and gene expression. Adipose tissue is also a physiological target of angiotensin II (AII)...
  40. doi request reprint Lipid effects of endocrine medications
    Dan V Mihailescu
    Department of Medicine, University of Illinois at Chicago, 1819 W Polk Street, M C 797, Chicago, IL, USA
    Curr Atheroscler Rep 13:88-94. 2011
    ....
  41. pmc Polycystic ovary syndrome is associated with atherogenic changes in lipoprotein particle number and size independent of body weight
    Seema Sidhwani
    Department of Medicine, Section of Endocrinology, Diabetes and MetabolismDepartment of Obstetrics and GynecologyDepartment of Medicine, University of Illinois, Chicago, IL, USA
    Clin Endocrinol (Oxf) 75:76-82. 2011
    ..We tested the hypothesis that PCOS is associated with atherogenic changes in lipoprotein profile independent of body weight and examined the role of insulin resistance and androgens in these atherogenic changes...
  42. ncbi request reprint Human cord blood stem cells and the journey to a cure for type 1 diabetes
    Yong Zhao
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Autoimmun Rev 10:103-7. 2010
    ....
  43. ncbi request reprint Human umbilical cord blood-derived f-macrophages retain pluripotentiality after thrombopoietin expansion
    Yong Zhao
    Section of Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, 1819 W Polk Street, Chicago, IL 60612, USA
    Exp Cell Res 310:311-8. 2005
    ..These findings demonstrate a potential use of CB f-Mphi and may lead to develop new therapeutic strategy for treating dominant disease...
  44. ncbi request reprint Hormone replacement therapy is associated with less coronary atherosclerosis in postmenopausal women
    Firas Akhrass
    Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Clin Endocrinol Metab 88:5611-4. 2003
    ....
  45. ncbi request reprint Divergent effects of peroxisome proliferator-activated receptor gamma agonists and tumor necrosis factor alpha on adipocyte ApoE expression
    Lili Yue
    Department of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 279:47626-32. 2004
    ..These results indicate for the first time that adipose tissue expression of apoE is modulated by physiologic regulators of insulin sensitivity...
  46. ncbi request reprint Ethnic differences predicting ketonuria in patients with Type 2 diabetes
    Rasa Kazlauskaite
    John H Stroger, Jr Hospital of Cook County, 1900 W Polk Street, Chicago, IL 60612, USA Rush University, Chicago, IL 60612, USA
    J Diabetes Complications 19:284-90. 2005
    ..We studied the correlates of ketonuria among African American and Hispanic/Latino patients with Type 2 diabetes who did not have ketoacidosis...
  47. ncbi request reprint Immune regulation of T lymphocyte by a newly characterized human umbilical cord blood stem cell
    Yong Zhao
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, 1819 W Polk Street, Chicago, IL 60612, USA
    Immunol Lett 108:78-87. 2007
    ..Our findings may advance our understanding of the immunobiology of stem cells and facilitate the therapeutic application of cord blood stem cells...
  48. ncbi request reprint Distinct cellular loci for the ABCA1-dependent and ABCA1-independent lipid efflux mediated by endogenous apolipoprotein E expression
    Zhi H Huang
    Department of Medicine, University of Illinois, Chicago, IL 60612, USA
    Arterioscler Thromb Vasc Biol 26:157-62. 2006
    ..We evaluated the relationship between apoE and ABCA1 for regulating cellular sterol efflux...
  49. ncbi request reprint Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model
    Yong Zhao
    Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
    Biochem Biophys Res Commun 399:629-36. 2010
    ..This model can provide a valuable tool for translational research into T1D...
  50. ncbi request reprint Tuberous xanthomas associated with olanzapine therapy and hypertriglyceridemia in the setting of a rare apolipoprotein E mutation
    Bridget P Sinnott
    Division of Endocrinology, University of Illinois, Chicago, Illinois 60612, USA
    Endocr Pract 12:183-7. 2006
    ..To describe a patient with tuberous xanthomas and high levels of cholesterol and triglycerides, who was found to have type III hyperlipoproteinemia (HLP) and a rare apolipoprotein E (apoE) mutation...
  51. ncbi request reprint Effects of leptin replacement on hypothalamic-pituitary growth hormone axis function and circulating ghrelin levels in ob/ob mice
    Raul M Luque
    Department of Medicine, University of Illinois at Chicago, and Jesse Brown VA Medical Center, Research and Development Division, M P 151, West Side, Suite no 6215, 820 South Damen Ave, Chicago, IL 60612, USA
    Am J Physiol Endocrinol Metab 292:E891-9. 2007
    ..These results demonstrate that leptin replacement has positive effects on multiple levels of GH axis function in ob/ob mice...
  52. pmc Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cells
    Yong Zhao
    Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Illinois at Chicago, 1819 West Polk Street, Chicago, IL 60612, USA
    BMC Med 10:3. 2012
    ....
  53. ncbi request reprint Measurement of liver fat content using selective saturation at 3.0 T
    Scott J Cotler
    Section of Hepatology, Department of Pathology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Magn Reson Imaging 25:743-8. 2007
    ..To validate an MRI technique for measuring liver fat content by calibrating MRI readings with liver phantoms and comparing MRI measurements in human subjects with estimates of liver fat content on liver biopsy specimens...
  54. ncbi request reprint ApoE-dependent sterol efflux from macrophages is modulated by scavenger receptor class B type I expression
    Zhi Hua Huang
    Department of Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    J Lipid Res 43:375-82. 2002
    ..This reduction of endogenous apoE is accompanied by reduced sterol efflux from macrophages...
  55. ncbi request reprint Regulation of macrophage ApoE expression and processing by extracellular matrix
    Yuwei Zhao
    Department of Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Biol Chem 277:29477-83. 2002
    ..The evolving composition of this matrix will, therefore, be important for regulating apoE expression and processing by vessel wall macrophages...
  56. ncbi request reprint Expression of scavenger receptor BI facilitates sterol movement between the plasma membrane and the endoplasmic reticulum in macrophages
    Z Hua Huang
    Department of Medicine, Rush Presbyterian Saint Luke s Medical Center, 1653 West Congress Parkway, Chicago, Illinois 60612, USA
    Biochemistry 42:3949-55. 2003
    ..It is concluded that expression of SR-BI in macrophages increases the rate of free cholesterol transport, and modulates free cholesterol distribution between the plasma membrane and the internal membrane compartments in macrophages...
  57. ncbi request reprint Oleic acid modulates the post-translational glycosylation of macrophage ApoE to increase its secretion
    Zhi Hua Huang
    Department of Medicine and Pharmacology, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Biol Chem 279:29195-201. 2004
    ..These results indicate that oleic acid increases apoE secretion from macrophages at a locus involving post-translational glycosylation...
  58. doi request reprint Hyperglycemia and acute coronary syndrome: a scientific statement from the American Heart Association Diabetes Committee of the Council on Nutrition, Physical Activity, and Metabolism
    Prakash Deedwania
    Anesthesiology 109:14-24. 2008
    ..Although firm guidelines will need to await completion of these clinical trials, the present statement also provides consensus recommendations for hyperglycemia management in patients with ACS on the basis of the available data...
  59. ncbi request reprint Ezetimibe/simvastatin vs atorvastatin in patients with type 2 diabetes mellitus and hypercholesterolemia: the VYTAL study
    Ronald B Goldberg
    Diabetes Research Institute, Miller School of Medicine, University of Miami, 1450 NW 10th Ave, Miami, FL 33136, USA
    Mayo Clin Proc 81:1579-88. 2006
    ..To compare the efficacy and safety of the recommended usual starting and next highest doses of ezetimibe/ simvastatin and atorvastatin in patients with type 2 diabetes mellitus and hypercholesterolemia...
  60. doi request reprint Hyperglycemia and acute coronary syndrome: a scientific statement from the American Heart Association Diabetes Committee of the Council on Nutrition, Physical Activity, and Metabolism
    Prakash Deedwania
    Circulation 117:1610-9. 2008
    ..Although firm guidelines will need to await completion of these clinical trials, the present statement also provides consensus recommendations for hyperglycemia management in patients with ACS on the basis of the available data...

Research Grants23

  1. Adipocyte Lipid Metabolism and ApoE Expression
    Theodore Mazzone; Fiscal Year: 2009
    ..For these studies, adipose tissue will be collected from the gluteal and abdominal subcutaneous regions, and from the intraperitoneal visceral region, of patients undergoing bariatric surgery;and utilized for isolation of adipocytes. ..
  2. CELL SURFACE METABOLISM OF MACROPHAGE DERIVED APO E
    Theodore Mazzone; Fiscal Year: 2001
    ..In this Specific Aim we will more thoroughly examine the metabolism of LDL and ALDL as it is influenced by the cell surface pool of macrophage derived apo E. ..
  3. MACROPHAGE CHOLESTEROL METABOLISM AND APO E SYNTHESIS
    Theodore Mazzone; Fiscal Year: 2000
    ..Understanding the mechanism by which aop E exerts its anti-atherogenic effect in the vessel wall will provide important insight into the pathobiology of the vessel wall lesion. ..
  4. Macrophage Cholesterol Metabolism and ApoE Synthesis
    Theodore Mazzone; Fiscal Year: 2007
    ..abstract_text> ..
  5. Macrophage Cholesterol Metabolism and ApoE Synthesis
    Theodore Mazzone; Fiscal Year: 2005
    ..abstract_text> ..
  6. MACROPHAGE CHOLESTEROL METABOLISM AND APO E SYNTHESIS
    Theodore Mazzone; Fiscal Year: 2001
    ..Understanding the mechanism by which aop E exerts its anti-atherogenic effect in the vessel wall will provide important insight into the pathobiology of the vessel wall lesion. ..
  7. CELL SURFACE METABOLISM OF MACROPHAGE DERIVED APO E
    Theodore Mazzone; Fiscal Year: 2000
    ..In this Specific Aim we will more thoroughly examine the metabolism of LDL and ALDL as it is influenced by the cell surface pool of macrophage derived apo E. ..
  8. CELL SURFACE METABOLISM OF MACROPHAGE DERIVED APO E
    Theodore Mazzone; Fiscal Year: 1999
    ..In this Specific Aim we will more thoroughly examine the metabolism of LDL and ALDL as it is influenced by the cell surface pool of macrophage derived apo E. ..
  9. MACROPHAGE CHOLESTEROL METABOLISM AND APO-E SYNTHESIS
    Theodore Mazzone; Fiscal Year: 1993
    ..Understanding the regulation of apoE production in macrophages could provide major insights into understanding the pathophysiology of disease processes in which macrophages play a key role, for example, atherosclerosis...
  10. Adipocyte Lipid Metabolism and ApoE Expression
    Theodore Mazzone; Fiscal Year: 2008
    ..For these studies, adipose tissue will be collected from the gluteal and abdominal subcutaneous regions, and from the intraperitoneal visceral region, of patients undergoing bariatric surgery; and utilized for isolation of adipocytes. ..
  11. Adipocyte Lipid Metabolism and ApoE Expression
    Theodore Mazzone; Fiscal Year: 2007
    ..For these studies, adipose tissue will be collected from the gluteal and abdominal subcutaneous regions, and from the intraperitoneal visceral region, of patients undergoing bariatric surgery; and utilized for isolation of adipocytes. ..
  12. Adipocyte Lipid Metabolism and ApoE Expression
    Theodore Mazzone; Fiscal Year: 2006
    ..For these studies, adipose tissue will be collected from the gluteal and abdominal subcutaneous regions, and from the intraperitoneal visceral region, of patients undergoing bariatric surgery; and utilized for isolation of adipocytes. ..
  13. Macrophage Cholesterol Metabolism and ApoE Synthesis
    Theodore Mazzone; Fiscal Year: 2006
    ..abstract_text> ..
  14. MACROPHAGE CHOLESTEROL METABOLISM AND APO E SYNTHESIS
    Theodore Mazzone; Fiscal Year: 1999
    ..Understanding the mechanism by which aop E exerts its anti-atherogenic effect in the vessel wall will provide important insight into the pathobiology of the vessel wall lesion. ..
  15. Macrophage Cholesterol Metabolism and ApoE Synthesis
    Theodore Mazzone; Fiscal Year: 2004
    ..abstract_text> ..
  16. Macrophage Cholesterol Metabolism and ApoE Synthesis
    Theodore Mazzone; Fiscal Year: 2003
    ..abstract_text> ..
  17. MACROPHAGE CHOLESTEROL METABOLISM AND APO E SYNTHESIS
    Theodore Mazzone; Fiscal Year: 1990
    ..Macrophage apo E synthesis and its regulation could have important implications for cholesterol balance of normal and diseased vessel wall tissue...