Andrey M Mazarati

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure-induced neurogenesis in the dentate gyrus
    Andrey Mazarati
    West Los Angeles VA Medical Center, and Department of Neurology, D Geffen Medical School, UCLA, Los Angeles, CA, USA
    Eur J Neurosci 19:3235-44. 2004
  2. pmc Neuroprotective and antiepileptogenic effects of combination of anti-inflammatory drugs in the immature brain
    Young Se Kwon
    Department of Pediatrics, Division of Neurology, David Geffen School of Medicine at UCLA, 22 474 MDCC in CHS, Los Angeles, CA 90095 1752, USA
    J Neuroinflammation 10:30. 2013
  3. ncbi request reprint Galanin and galanin receptors in epilepsy
    Andrey M Mazarati
    West Los Angeles VA Medical Center, Research 151, Los Angeles, CA 90073, USA
    Neuropeptides 38:331-43. 2004
  4. ncbi request reprint Regulation of limbic status epilepticus by hippocampal galanin type 1 and type 2 receptors
    Andrey Mazarati
    West Los Angeles VA Medical Center, Research 151, Los Angeles, CA 90073, USA
    Neuropeptides 39:277-80. 2005
  5. pmc In vivo interaction between serotonin and galanin receptors types 1 and 2 in the dorsal raphe: implication for limbic seizures
    Andrey M Mazarati
    Department of Pediatrics, Division of Pediatric Neurology, D Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Neurochem 95:1495-503. 2005
  6. pmc Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: The effects of subtype-selective agonists and the role of G-protein-mediated signaling
    Andrey Mazarati
    Department of Pediatrics, Division of Pediatric Neurology, D Geffen School of Medicine at UCLA, Box 951752, 22 474 MDCC, Los Angeles, CA 90095 1752, USA
    J Pharmacol Exp Ther 318:700-8. 2006
  7. pmc Kindling epileptogenesis in immature rats leads to persistent depressive behavior
    Andrey Mazarati
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Room 22 474 MDCC, Los Angeles, CA 90095 1752, USA
    Epilepsy Behav 10:377-83. 2007
  8. pmc Antiepileptogenic and antiictogenic effects of retigabine under conditions of rapid kindling: an ontogenic study
    Andrey Mazarati
    Department of Pediatrics, Neurology Division, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1752, USA
    Epilepsia 49:1777-86. 2008
  9. pmc Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine
    Andrey Mazarati
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1752, USA
    Brain 131:2071-83. 2008
  10. pmc Bumetanide inhibits rapid kindling in neonatal rats
    Andrey Mazarati
    Department of Pediatrics, Neurology Division, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1752, USA
    Epilepsia 50:2117-22. 2009

Research Grants

  1. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2010
  2. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2003
  3. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2006

Detail Information

Publications30

  1. ncbi request reprint Galanin type 2 receptors regulate neuronal survival, susceptibility to seizures and seizure-induced neurogenesis in the dentate gyrus
    Andrey Mazarati
    West Los Angeles VA Medical Center, and Department of Neurology, D Geffen Medical School, UCLA, Los Angeles, CA, USA
    Eur J Neurosci 19:3235-44. 2004
    ..These results are important for understanding the role of galanin and galanin receptor subtypes in the hippocampus both under normal conditions and in excitotoxic injury...
  2. pmc Neuroprotective and antiepileptogenic effects of combination of anti-inflammatory drugs in the immature brain
    Young Se Kwon
    Department of Pediatrics, Division of Neurology, David Geffen School of Medicine at UCLA, 22 474 MDCC in CHS, Los Angeles, CA 90095 1752, USA
    J Neuroinflammation 10:30. 2013
    ....
  3. ncbi request reprint Galanin and galanin receptors in epilepsy
    Andrey M Mazarati
    West Los Angeles VA Medical Center, Research 151, Los Angeles, CA 90073, USA
    Neuropeptides 38:331-43. 2004
    ..We also address recently established functions of galanin in seizure-associated neuronal degeneration and neuronal plasticity...
  4. ncbi request reprint Regulation of limbic status epilepticus by hippocampal galanin type 1 and type 2 receptors
    Andrey Mazarati
    West Los Angeles VA Medical Center, Research 151, Los Angeles, CA 90073, USA
    Neuropeptides 39:277-80. 2005
    ..GalR1 and GalR2 exhibit differential effects on the initiation and the maintenance phases of SE. Activation of both galanin receptor subtypes exerts neuroprotective effects under conditions of excitotoxic injury...
  5. pmc In vivo interaction between serotonin and galanin receptors types 1 and 2 in the dorsal raphe: implication for limbic seizures
    Andrey M Mazarati
    Department of Pediatrics, Division of Pediatric Neurology, D Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Neurochem 95:1495-503. 2005
    ....
  6. pmc Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: The effects of subtype-selective agonists and the role of G-protein-mediated signaling
    Andrey Mazarati
    Department of Pediatrics, Division of Pediatric Neurology, D Geffen School of Medicine at UCLA, Box 951752, 22 474 MDCC, Los Angeles, CA 90095 1752, USA
    J Pharmacol Exp Ther 318:700-8. 2006
    ..The data are important for understanding endogenous mechanisms regulating epileptogenesis and for the development of novel antiepileptogenic drugs...
  7. pmc Kindling epileptogenesis in immature rats leads to persistent depressive behavior
    Andrey Mazarati
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Room 22 474 MDCC, Los Angeles, CA 90095 1752, USA
    Epilepsy Behav 10:377-83. 2007
    ..We conclude that neuronal plastic changes associated with the kindling state are accompanied by the development of depressive behavior...
  8. pmc Antiepileptogenic and antiictogenic effects of retigabine under conditions of rapid kindling: an ontogenic study
    Andrey Mazarati
    Department of Pediatrics, Neurology Division, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1752, USA
    Epilepsia 49:1777-86. 2008
    ..To examine antiepileptogenic and antiictogenic potential of retigabine (RTG) under conditions of rapid kindling epileptogenesis during different stages of development...
  9. pmc Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine
    Andrey Mazarati
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1752, USA
    Brain 131:2071-83. 2008
    ..The finding that behavioural equivalents of depression were resistant to an antidepressant medication suggested that depression in epilepsy might have distinct underlying mechanisms beyond alterations in serotonergic pathways...
  10. pmc Bumetanide inhibits rapid kindling in neonatal rats
    Andrey Mazarati
    Department of Pediatrics, Neurology Division, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1752, USA
    Epilepsia 50:2117-22. 2009
    ..To examine the effects of bumetanide, a selective blocker of Na+-K+-2Cl- cotransporter (NKCC1), on hippocampal excitability and rapid kindling in immature rats...
  11. pmc Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy
    Andrey M Mazarati
    Department of Pediatrics, Neurology Division, David Geffen School of Medicine, University of California Los Angeles, Box 951752, 22 474 MDCC, Los Angeles, CA 90095 1752, USA
    Neurobiol Dis 34:457-61. 2009
    ..We suggest that the observed hyperactivity of the HPA axis may underlie co-morbidity between epilepsy and depression...
  12. pmc Comorbidity between epilepsy and depression: role of hippocampal interleukin-1beta
    Andrey M Mazarati
    Department of Pediatrics, Neurology Division, D Geffen School of Medicine at UCLA, 22 474 MDCC, Los Angeles, CA 90095 1752, USA
    Neurobiol Dis 37:461-7. 2010
    ..These findings implicate hippocampal IL-1beta in epilepsy-associated depression and provide a rationale for the introduction of IL-1beta blockers in the treatment of depression in TLE...
  13. pmc High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and Receptor for Advanced Glycation End Products
    Andrey Mazarati
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1752, USA
    Exp Neurol 232:143-8. 2011
    ..This mechanism may contribute to memory deficits under various neurological and psychiatric conditions associated with the increased HMGB1 levels, such as epilepsy, Alzheimer's disease and stroke...
  14. pmc Patterns of seizures, hippocampal injury and neurogenesis in three models of status epilepticus in galanin receptor type 1 (GalR1) knockout mice
    A Mazarati
    West Los Angeles Veteran Administration Medical Center, Research 151, 11301 Wilshire Boulevard, CA 90073, USA
    Neuroscience 128:431-41. 2004
    ..The results justify the development and use of GalR1 agonists in the treatment of certain forms of epilepsy...
  15. ncbi request reprint Anticonvulsant effects of levetiracetam and levetiracetam-diazepam combinations in experimental status epilepticus
    Andrey M Mazarati
    Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Epilepsy Res 58:167-74. 2004
    ..We conclude that LEV deserves further evaluation in the treatment of status epilepticus...
  16. ncbi request reprint Blockers of NMDA receptor restore paired-pulse inhibition in the rat dentate gyrus lesioned by perforant path stimulation
    A M Mazarati
    Department of Neurology, UCLA School of Medicine, USA
    Neurosci Lett 234:135-8. 1997
    ....
  17. ncbi request reprint Self-sustaining status epilepticus after brief electrical stimulation of the perforant path
    A M Mazarati
    Veteran Administration Medical Center, Neurology Service, UCLA School of Medicine, Sepulveda, USA
    Brain Res 801:251-3. 1998
    ..The animals killed 3 days after SSSE showed extensive neuronal damage. Those which were allowed to survive for 6 weeks after SSSE displayed spontaneous seizures...
  18. ncbi request reprint N-methyl-D-asparate receptor antagonists abolish the maintenance phase of self-sustaining status epilepticus in rat
    A M Mazarati
    Department of Neurology and Brain Research Institute, UCLA School of Medicine, Los Angeles, CA, USA
    Neurosci Lett 265:187-90. 1999
    ..We suggest that the maintenance phase of SSSE depends on activation of NMDA receptors and that NMDA receptor blockers may be a promising class of compounds for the treatment of status epilepticus...
  19. ncbi request reprint Felbamate in experimental model of status epilepticus
    A M Mazarati
    Greater Los Angeles Health Care System, Sepulveda 91343 2099, California, USA
    Epilepsia 41:123-7. 2000
    ..To examine the putative seizure-protective properties of felbamate in an animal model of self-sustaining status epilepticus (SSSE)...
  20. ncbi request reprint Galanin: an endogenous anticonvulsant?
    A Mazarati
    Department of Neurology, UCLA School of Medicine and West LA VA Medical Center, Los Angeles, CA 90073, USA
    Neuroscientist 7:506-17. 2001
    ....
  21. ncbi request reprint Selective facilitation of kindled seizures from the amygdala after hippocampal lesions induced by perforant path stimulation
    A M Mazarati
    Department of Neurology, UCLA School of Medicine, USA
    Neurosci Lett 224:165-8. 1997
    ..After amygdala kindling, some animals showed spontaneous seizures. PPS may recruit amygdala into the epileptogenic circuit, resulting in "latent' kindling and development of spontaneous seizures...
  22. ncbi request reprint Anticonvulsant effects of four neuropeptides in the rat hippocampus during self-sustaining status epilepticus
    Andrey Mazarati
    Department of Neurology and Brain Research Institute, University of California, Los Angeles, USA
    Neurosci Lett 331:123-7. 2002
    ....
  23. ncbi request reprint Epileptogenesis after self-sustaining status epilepticus
    Andrey Mazarati
    Department of Neurology, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Epilepsia 43:74-80. 2002
    ..To describe the natural history of chronic epilepsy after experimental self-sustaining status epilepticus (SSSE) and to correlate patterns of SSSE with ictal, interictal, and plastic changes that characterize chronic epilepsy...
  24. pmc Comorbidity between epilepsy and depression: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms
    Eduardo Pineda
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1752, USA
    Epilepsia 51:110-4. 2010
    ....
  25. ncbi request reprint Seizure-induced neuronal death in the immature brain
    Claude G Wasterlain
    Epilepsy Research Laboratory, VA Greater Los Angeles Healthcare System, Department of Neurology Brain Research Institute, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Prog Brain Res 135:335-53. 2002
    ..Seizure-induced necrosis has many of the biochemical features of apoptosis, with early cytochrome release from mitochondria and capase activation. We speculate that this form of necrosis is associated with seizure-induced energy failure...
  26. ncbi request reprint Short-term plasticity of hippocampal neuropeptides and neuronal circuitry in experimental status epilepticus
    Claude G Wasterlain
    Department of Neurology, VA Greater Los Angeles Healthcare System 127, 11301 Wilshire Boulevard, West Los Angeles, CA 90073, USA
    Epilepsia 43:20-9. 2002
    ....
  27. pmc Interleukin-1β causes fluoxetine resistance in an animal model of epilepsy-associated depression
    Eduardo A Pineda
    Department of Pediatrics, Neurology Division, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Neurotherapeutics 9:477-85. 2012
    ..In such forms of depression, the use of interleukin-1β blockers in conjunction with SSRI may represent an effective therapeutic approach...
  28. ncbi request reprint Anticonvulsant and antiepileptogenic effects of fluorofelbamate in experimental status epilepticus
    Andrey M Mazarati
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
    Seizure 11:423-30. 2002
    ..To examine the seizure-protective properties of fluorofelbamate, a felbamate analog, on acute and chronic seizures in an experimental model of self-sustaining status epilepticus (SSSE)...
  29. pmc Plasticity of presynaptic and postsynaptic serotonin 1A receptors in an animal model of epilepsy-associated depression
    Eduardo A Pineda
    Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095 1752, USA
    Neuropsychopharmacology 36:1305-16. 2011
    ..Downregulation of postsynaptic 5-HT1A receptors may further exacerbate the severity of epilepsy-associated depression...
  30. pmc Anticonvulsant activity of a nonpeptide galanin receptor agonist
    Külliki Saar
    Department of Neurochemistry and Neurotoxicology, Stockholm University, SE 10691 Stockholm, Sweden
    Proc Natl Acad Sci U S A 99:7136-41. 2002
    ..These findings introduce a systemically active nonpeptide galanin agonist anticonvulsant...

Research Grants7

  1. Mechanisms of comorbidity between epilepsy and depression
    Andrey M Mazarati; Fiscal Year: 2010
    ..Advancement of knowledge in this area will likely contribute to the development of effective therapy and the improvement of quality of life in those patients who suffer from both epilepsy and depression. ..
  2. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2003
    ....
  3. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2006
    ..abstract_text> ..