MARTY MAYO

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint A1 adenosine receptor overexpression attenuates ischemia-reperfusion-induced apoptosis and caspase 3 activity
    Sara E Regan
    Department of Pediatrics, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Am J Physiol Heart Circ Physiol 284:H859-66. 2003
  2. pmc The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors
    Thomas W Sturgill
    Departments of Pharmacology and Internal Medicine, University of Virginia, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908, USA
    Mol Cancer 9:104. 2010
  3. pmc Application of machine learning methods to histone methylation ChIP-Seq data reveals H4R3me2 globally represses gene expression
    Xiaojiang Xu
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia, USA
    BMC Bioinformatics 11:396. 2010
  4. ncbi request reprint PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunit
    Marty W Mayo
    Department of Biochemistry, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 277:11116-25. 2002
  5. ncbi request reprint Ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of NF-kappa B through the Akt pathway
    Marty W Mayo
    Department of Surgery, The University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 278:18980-9. 2003
  6. ncbi request reprint Inhibition of nuclear factor kappaB chemosensitizes non-small cell lung cancer through cytochrome c release and caspase activation
    David R Jones
    Department of Surgery, The University of Virginia, Charlottesville, VA 22908 0679, USA
    J Thorac Cardiovasc Surg 123:310-7. 2002
  7. ncbi request reprint SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival
    Jamie E Hoberg
    Department of Biochemistry and Molecular Genetics, The University of Virginia, Charlottesville, VA 22908, USA
    Mol Cell 16:245-55. 2004
  8. ncbi request reprint Combined proteasome and histone deacetylase inhibition in non-small cell lung cancer
    Chadrick E Denlinger
    Department of Surgery, University of Virginia School of Medicine, Charlottesville, 22908, USA
    J Thorac Cardiovasc Surg 127:1078-86. 2004
  9. ncbi request reprint Transcriptional repression of TFF1 in gastric epithelial cells by CCAAT/enhancer binding protein-beta
    Narendra V Sankpal
    Division of Gastroenterology and Hepatology, University of Virginia Health System, Charlottesville, VA 22908 0708, USA
    Biochim Biophys Acta 1728:1-10. 2005
  10. pmc Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
    Fan Yeung
    Department of Biochemistry and Molecular Genetics, The University of Virginia, Charlottesville, VA 22908, USA
    EMBO J 23:2369-80. 2004

Collaborators

  • David R Jones
  • Thomas W Sturgill
  • Leland W Chung
  • M R Freeman
  • Amy R Lankford
  • Yang Shi
  • COLIN DUCKETT
  • Jamie E Hoberg
  • Fan Yeung
  • Xiaojiang Xu
  • Jialiang Wang
  • Vanessa Fern├índez-Majada
  • Ezra Burstein
  • Catherine S Ramsey
  • Narendra V Sankpal
  • Chadrick E Denlinger
  • Michael D Keller
  • Bekir Cinar
  • Sara E Regan
  • Stephen Hoang
  • Stefan Bekiranov
  • Felip Vilardell
  • Hanbing An
  • Anna Bigas
  • Wendell G Yarbrough
  • Jaume Pujadas
  • Gabriel Capella
  • Albert S Baldwin
  • Lluis Espinosa
  • Anita E Popko
  • John C Wilkinson
  • Steven M Powell
  • Rebecca A Csomos
  • Julie M Rumble
  • Gabriel N Maine
  • Christine M Komarck
  • Amanda S Wilkinson
  • Haiyen E Zhau
  • R Michael Broad
  • Roy A Frye
  • Hiroyuki Konaka
  • Rachael J Cerniway
  • Anne M Byford
  • Michael Broad
  • G Paul Matherne

Detail Information

Publications15

  1. ncbi request reprint A1 adenosine receptor overexpression attenuates ischemia-reperfusion-induced apoptosis and caspase 3 activity
    Sara E Regan
    Department of Pediatrics, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Am J Physiol Heart Circ Physiol 284:H859-66. 2003
    ..These data suggest that cardioprotection with transgenic overexpression of A(1) adenosine receptors involves attenuation of I/R-induced apoptosis that does not involve acute signaling through phosphoinositol-3-kinase...
  2. pmc The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors
    Thomas W Sturgill
    Departments of Pharmacology and Internal Medicine, University of Virginia, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908, USA
    Mol Cancer 9:104. 2010
    ..3 kb. We hypothesized ICK and FBX9 are potentially important genes in cancer controlled by a bidirectional promoter...
  3. pmc Application of machine learning methods to histone methylation ChIP-Seq data reveals H4R3me2 globally represses gene expression
    Xiaojiang Xu
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia, USA
    BMC Bioinformatics 11:396. 2010
    ..An extremely promising and underexplored area of research is the application of machine learning methods, which are designed to construct predictive network models, to these large-scale epigenomic data sets...
  4. ncbi request reprint PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunit
    Marty W Mayo
    Department of Biochemistry, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 277:11116-25. 2002
    ..Maintenance of the PTEN tumor suppressor protein is therefore required to modulate Akt activity and to concomitantly control the transcriptional activity of the anti-apoptotic transcription factor NF-kappaB...
  5. ncbi request reprint Ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of NF-kappa B through the Akt pathway
    Marty W Mayo
    Department of Surgery, The University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 278:18980-9. 2003
    ..Our study indicates that the ineffectiveness of HDAC inhibitors to induce apoptosis in NSCLC cancer cells is associated with the ability of these molecules to stimulate NF-kappa B-dependent transcription and cell survival...
  6. ncbi request reprint Inhibition of nuclear factor kappaB chemosensitizes non-small cell lung cancer through cytochrome c release and caspase activation
    David R Jones
    Department of Surgery, The University of Virginia, Charlottesville, VA 22908 0679, USA
    J Thorac Cardiovasc Surg 123:310-7. 2002
    ....
  7. ncbi request reprint SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival
    Jamie E Hoberg
    Department of Biochemistry and Molecular Genetics, The University of Virginia, Charlottesville, VA 22908, USA
    Mol Cell 16:245-55. 2004
    ..Our work provides evidence that IKKalpha orchestrates SMRT derepression, a prerequisite for NF-kappaB transcription and survival...
  8. ncbi request reprint Combined proteasome and histone deacetylase inhibition in non-small cell lung cancer
    Chadrick E Denlinger
    Department of Surgery, University of Virginia School of Medicine, Charlottesville, 22908, USA
    J Thorac Cardiovasc Surg 127:1078-86. 2004
    ..We hypothesize that nuclear factor kappa B inhibition with the proteasome inhibitor bortezomib (formerly known as PS-341) will sensitize non-small cell lung cancer cells to histone deacetylase inhibitor-mediated apoptosis...
  9. ncbi request reprint Transcriptional repression of TFF1 in gastric epithelial cells by CCAAT/enhancer binding protein-beta
    Narendra V Sankpal
    Division of Gastroenterology and Hepatology, University of Virginia Health System, Charlottesville, VA 22908 0708, USA
    Biochim Biophys Acta 1728:1-10. 2005
    ....
  10. pmc Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
    Fan Yeung
    Department of Biochemistry and Molecular Genetics, The University of Virginia, Charlottesville, VA 22908, USA
    EMBO J 23:2369-80. 2004
    ....
  11. pmc Identification of a negative regulatory cis-element in the enhancer core region of the prostate-specific antigen promoter: implications for intersection of androgen receptor and nuclear factor-kappaB signalling in prostate cancer cells
    Bekir Cinar
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Biochem J 379:421-31. 2004
    ..Collectively, these data indicate that cross-modulation between AR and NF-kappaB p65 transcription factors may occur by a novel mechanism involving binding to a common cis -DNA element...
  12. pmc IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300
    Jamie E Hoberg
    Department of Biochemistry and Molecular Genetics, Box 800733, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 26:457-71. 2006
    ....
  13. ncbi request reprint LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB
    Jialiang Wang
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA
    Cancer Cell 12:239-51. 2007
    ..In aggregate, these data support a role of LZAP in NF-kappaB regulation and tumor suppression...
  14. ncbi request reprint Aberrant cytoplasmic localization of N-CoR in colorectal tumors
    Vanessa Fernández-Majada
    Centre Oncologia Molecular, Institut d Investigacio Biomedica de Bellvitge, Hospitalet, Barcelona, Spain
    Cell Cycle 6:1748-52. 2007
    ..Moreover, we have analyzed the subcellular localization of N-CoR in 43 colorectal cancer samples and we have found that aberrant cytoplasmic distribution of N-CoR is a general trait of these tumors...
  15. ncbi request reprint COMMD proteins, a novel family of structural and functional homologs of MURR1
    Ezra Burstein
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    J Biol Chem 280:22222-32. 2005
    ....

Research Grants16

  1. Antiapoptotic Role of NF-kB in Calcium Signaling
    MARTY MAYO; Fiscal Year: 2003
    ....
  2. Inflammatory Cytokines Link NF-kappaB with Bim Degradation and Metastasis
    Marty W Mayo; Fiscal Year: 2010
    ..Understanding the mechanisms used by inflammatory mediators to stimulate Bim degradation will potentially result in the identification of novel approaches to preventing NSCLC metastasis. ..
  3. Role of IKK in NSCLC Modulation of SMRT and NF-kappab
    MARTY MAYO; Fiscal Year: 2007
    ..This new understanding would provide a useful NSCLC marker and would potentially identify an important molecular target that may result in novel treatment strategies for this deadly disease. ..
  4. Antiapoptotic Role of NF-kB in Calcium Signaling
    MARTY MAYO; Fiscal Year: 2007
    ..abstract_text> ..
  5. Antiapoptotic Role of NF-kB in Calcium Signaling
    MARTY MAYO; Fiscal Year: 2006
    ..abstract_text> ..
  6. ONCOGENIC RAS REQUIRES NFKB ANTIAPOPTOTIC FUNCTION
    MARTY MAYO; Fiscal Year: 2003
    ..These studies will elucidate the mechanisms by which NF kappa B provides protection against apoptosis in response to oncogenic Ras and will potentially provide new insight into the development of anticancer therapies. ..
  7. Role of IKK in NSCLC: Modulation of SMRT and NF-kappaB
    Marty W Mayo; Fiscal Year: 2010
    ..The overall goal of this project is use these newly identified gene products as novel therapeutic targets for detection and treatment of NSCLC. ..