MARTY MAYO

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint A1 adenosine receptor overexpression attenuates ischemia-reperfusion-induced apoptosis and caspase 3 activity
    Sara E Regan
    Department of Pediatrics, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Am J Physiol Heart Circ Physiol 284:H859-66. 2003
  2. pmc NF-κB regulates mesenchymal transition for the induction of non-small cell lung cancer initiating cells
    Manish Kumar
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA
    PLoS ONE 8:e68597. 2013
  3. pmc The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors
    Thomas W Sturgill
    Departments of Pharmacology and Internal Medicine, University of Virginia, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908, USA
    Mol Cancer 9:104. 2010
  4. pmc Application of machine learning methods to histone methylation ChIP-Seq data reveals H4R3me2 globally represses gene expression
    Xiaojiang Xu
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia, USA
    BMC Bioinformatics 11:396. 2010
  5. ncbi request reprint PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunit
    Marty W Mayo
    Department of Biochemistry, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 277:11116-25. 2002
  6. ncbi request reprint Ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of NF-kappa B through the Akt pathway
    Marty W Mayo
    Department of Surgery, The University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 278:18980-9. 2003
  7. ncbi request reprint Combined proteasome and histone deacetylase inhibition in non-small cell lung cancer
    Chadrick E Denlinger
    Department of Surgery, University of Virginia School of Medicine, Charlottesville, 22908, USA
    J Thorac Cardiovasc Surg 127:1078-86. 2004
  8. ncbi request reprint Inhibition of nuclear factor kappaB chemosensitizes non-small cell lung cancer through cytochrome c release and caspase activation
    David R Jones
    Department of Surgery, The University of Virginia, Charlottesville, VA 22908 0679, USA
    J Thorac Cardiovasc Surg 123:310-7. 2002
  9. ncbi request reprint SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival
    Jamie E Hoberg
    Department of Biochemistry and Molecular Genetics, The University of Virginia, Charlottesville, VA 22908, USA
    Mol Cell 16:245-55. 2004
  10. ncbi request reprint Transcriptional repression of TFF1 in gastric epithelial cells by CCAAT/enhancer binding protein-beta
    Narendra V Sankpal
    Division of Gastroenterology and Hepatology, University of Virginia Health System, Charlottesville, VA 22908 0708, USA
    Biochim Biophys Acta 1728:1-10. 2005

Research Grants

Collaborators

  • David R Jones
  • Thomas W Sturgill
  • Leland W Chung
  • M R Freeman
  • Amy R Lankford
  • Yang Shi
  • COLIN DUCKETT
  • Jamie E Hoberg
  • Fan Yeung
  • Manish Kumar
  • Stefan Bekiranov
  • Xiaojiang Xu
  • Jialiang Wang
  • Vanessa Fernández-Majada
  • Narendra V Sankpal
  • Ezra Burstein
  • Catherine S Ramsey
  • Chadrick E Denlinger
  • Michael D Keller
  • Bekir Cinar
  • Sara E Regan
  • David F Allison
  • Natalya N Baranova
  • J Jacob Wamsley
  • Adam J Katz
  • Stephen Hoang
  • Wendell G Yarbrough
  • Albert S Baldwin
  • Anna Bigas
  • Hanbing An
  • Gabriel Capella
  • Lluis Espinosa
  • Felip Vilardell
  • Jaume Pujadas
  • Anita E Popko
  • Steven M Powell
  • John C Wilkinson
  • Amanda S Wilkinson
  • Julie M Rumble
  • Rebecca A Csomos
  • Gabriel N Maine
  • Christine M Komarck
  • Haiyen E Zhau
  • Roy A Frye
  • R Michael Broad
  • Hiroyuki Konaka
  • Anne M Byford
  • G Paul Matherne
  • Michael Broad
  • Rachael J Cerniway

Detail Information

Publications16

  1. ncbi request reprint A1 adenosine receptor overexpression attenuates ischemia-reperfusion-induced apoptosis and caspase 3 activity
    Sara E Regan
    Department of Pediatrics, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    Am J Physiol Heart Circ Physiol 284:H859-66. 2003
    ..These data suggest that cardioprotection with transgenic overexpression of A(1) adenosine receptors involves attenuation of I/R-induced apoptosis that does not involve acute signaling through phosphoinositol-3-kinase...
  2. pmc NF-κB regulates mesenchymal transition for the induction of non-small cell lung cancer initiating cells
    Manish Kumar
    Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia, USA
    PLoS ONE 8:e68597. 2013
    ..Our work indicates that NF-κB is required for NSCLC metastasis, in part, by transcriptionally upregulating master-switch transcription factors required for EMT. ..
  3. pmc The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factors
    Thomas W Sturgill
    Departments of Pharmacology and Internal Medicine, University of Virginia, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908, USA
    Mol Cancer 9:104. 2010
    ..3 kb. We hypothesized ICK and FBX9 are potentially important genes in cancer controlled by a bidirectional promoter...
  4. pmc Application of machine learning methods to histone methylation ChIP-Seq data reveals H4R3me2 globally represses gene expression
    Xiaojiang Xu
    Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia, USA
    BMC Bioinformatics 11:396. 2010
    ..An extremely promising and underexplored area of research is the application of machine learning methods, which are designed to construct predictive network models, to these large-scale epigenomic data sets...
  5. ncbi request reprint PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunit
    Marty W Mayo
    Department of Biochemistry, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 277:11116-25. 2002
    ..Maintenance of the PTEN tumor suppressor protein is therefore required to modulate Akt activity and to concomitantly control the transcriptional activity of the anti-apoptotic transcription factor NF-kappaB...
  6. ncbi request reprint Ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of NF-kappa B through the Akt pathway
    Marty W Mayo
    Department of Surgery, The University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 278:18980-9. 2003
    ..Our study indicates that the ineffectiveness of HDAC inhibitors to induce apoptosis in NSCLC cancer cells is associated with the ability of these molecules to stimulate NF-kappa B-dependent transcription and cell survival...
  7. ncbi request reprint Combined proteasome and histone deacetylase inhibition in non-small cell lung cancer
    Chadrick E Denlinger
    Department of Surgery, University of Virginia School of Medicine, Charlottesville, 22908, USA
    J Thorac Cardiovasc Surg 127:1078-86. 2004
    ..We hypothesize that nuclear factor kappa B inhibition with the proteasome inhibitor bortezomib (formerly known as PS-341) will sensitize non-small cell lung cancer cells to histone deacetylase inhibitor-mediated apoptosis...
  8. ncbi request reprint Inhibition of nuclear factor kappaB chemosensitizes non-small cell lung cancer through cytochrome c release and caspase activation
    David R Jones
    Department of Surgery, The University of Virginia, Charlottesville, VA 22908 0679, USA
    J Thorac Cardiovasc Surg 123:310-7. 2002
    ....
  9. ncbi request reprint SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival
    Jamie E Hoberg
    Department of Biochemistry and Molecular Genetics, The University of Virginia, Charlottesville, VA 22908, USA
    Mol Cell 16:245-55. 2004
    ..Our work provides evidence that IKKalpha orchestrates SMRT derepression, a prerequisite for NF-kappaB transcription and survival...
  10. ncbi request reprint Transcriptional repression of TFF1 in gastric epithelial cells by CCAAT/enhancer binding protein-beta
    Narendra V Sankpal
    Division of Gastroenterology and Hepatology, University of Virginia Health System, Charlottesville, VA 22908 0708, USA
    Biochim Biophys Acta 1728:1-10. 2005
    ....
  11. pmc Identification of a negative regulatory cis-element in the enhancer core region of the prostate-specific antigen promoter: implications for intersection of androgen receptor and nuclear factor-kappaB signalling in prostate cancer cells
    Bekir Cinar
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Biochem J 379:421-31. 2004
    ..Collectively, these data indicate that cross-modulation between AR and NF-kappaB p65 transcription factors may occur by a novel mechanism involving binding to a common cis -DNA element...
  12. pmc Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
    Fan Yeung
    Department of Biochemistry and Molecular Genetics, The University of Virginia, Charlottesville, VA 22908, USA
    EMBO J 23:2369-80. 2004
    ....
  13. pmc IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300
    Jamie E Hoberg
    Department of Biochemistry and Molecular Genetics, Box 800733, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Cell Biol 26:457-71. 2006
    ....
  14. ncbi request reprint LZAP, a putative tumor suppressor, selectively inhibits NF-kappaB
    Jialiang Wang
    Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA
    Cancer Cell 12:239-51. 2007
    ..In aggregate, these data support a role of LZAP in NF-kappaB regulation and tumor suppression...
  15. ncbi request reprint COMMD proteins, a novel family of structural and functional homologs of MURR1
    Ezra Burstein
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    J Biol Chem 280:22222-32. 2005
    ....
  16. ncbi request reprint Aberrant cytoplasmic localization of N-CoR in colorectal tumors
    Vanessa Fernández-Majada
    Centre Oncologia Molecular, Institut d Investigacio Biomedica de Bellvitge, Hospitalet, Barcelona, Spain
    Cell Cycle 6:1748-52. 2007
    ..Moreover, we have analyzed the subcellular localization of N-CoR in 43 colorectal cancer samples and we have found that aberrant cytoplasmic distribution of N-CoR is a general trait of these tumors...

Research Grants2

  1. ONCOGENIC RAS REQUIRES NFKB ANTIAPOPTOTIC FUNCTION
    MARTY MAYO; Fiscal Year: 2003
    ..These studies will elucidate the mechanisms by which NF kappa B provides protection against apoptosis in response to oncogenic Ras and will potentially provide new insight into the development of anticancer therapies. ..
  2. Antiapoptotic Role of NF-kB in Calcium Signaling
    MARTY MAYO; Fiscal Year: 2007
    ..abstract_text> ..