Research Topics
Species | MARTY MAYOSummaryAffiliation: University of Virginia Country: USA Publications
Research Grants
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Detail Information
Publications
A1 adenosine receptor overexpression attenuates ischemia-reperfusion-induced apoptosis and caspase 3 activitySara E Regan
Department of Pediatrics, University of Virginia Health System, Charlottesville, Virginia 22908, USA
Am J Physiol Heart Circ Physiol 284:H859-66. 2003..These data suggest that cardioprotection with transgenic overexpression of A(1) adenosine receptors involves attenuation of I/R-induced apoptosis that does not involve acute signaling through phosphoinositol-3-kinase...
The promoter for intestinal cell kinase is head-to-head with F-Box 9 and contains functional sites for TCF7L2 and FOXA factorsThomas W Sturgill
Departments of Pharmacology and Internal Medicine, University of Virginia, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908, USA
Mol Cancer 9:104. 2010..3 kb. We hypothesized ICK and FBX9 are potentially important genes in cancer controlled by a bidirectional promoter...- Application of machine learning methods to histone methylation ChIP-Seq data reveals H4R3me2 globally represses gene expressionXiaojiang Xu
Department of Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, Virginia, USA
BMC Bioinformatics 11:396. 2010..An extremely promising and underexplored area of research is the application of machine learning methods, which are designed to construct predictive network models, to these large-scale epigenomic data sets... - PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunitMarty W Mayo
Department of Biochemistry, University of Virginia, Charlottesville, Virginia 22908, USA
J Biol Chem 277:11116-25. 2002..Maintenance of the PTEN tumor suppressor protein is therefore required to modulate Akt activity and to concomitantly control the transcriptional activity of the anti-apoptotic transcription factor NF-kappaB... - Ineffectiveness of histone deacetylase inhibitors to induce apoptosis involves the transcriptional activation of NF-kappa B through the Akt pathwayMarty W Mayo
Department of Surgery, The University of Virginia, Charlottesville, Virginia 22908, USA
J Biol Chem 278:18980-9. 2003..Our study indicates that the ineffectiveness of HDAC inhibitors to induce apoptosis in NSCLC cancer cells is associated with the ability of these molecules to stimulate NF-kappa B-dependent transcription and cell survival... - Inhibition of nuclear factor kappaB chemosensitizes non-small cell lung cancer through cytochrome c release and caspase activationDavid R Jones
Department of Surgery, The University of Virginia, Charlottesville, VA 22908 0679, USA
J Thorac Cardiovasc Surg 123:310-7. 2002.... - SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survivalJamie E Hoberg
Department of Biochemistry and Molecular Genetics, The University of Virginia, Charlottesville, VA 22908, USA
Mol Cell 16:245-55. 2004..Our work provides evidence that IKKalpha orchestrates SMRT derepression, a prerequisite for NF-kappaB transcription and survival... - Combined proteasome and histone deacetylase inhibition in non-small cell lung cancerChadrick E Denlinger
Department of Surgery, University of Virginia School of Medicine, Charlottesville, 22908, USA
J Thorac Cardiovasc Surg 127:1078-86. 2004..Pharmacologic nuclear factor kappa B suppression through proteasome inhibition, followed by treatment with histone deacetylase inhibitors, might represent a novel treatment strategy for patients with non-small cell lung cancer... - Transcriptional repression of TFF1 in gastric epithelial cells by CCAAT/enhancer binding protein-betaNarendra V Sankpal
Division of Gastroenterology and Hepatology, University of Virginia Health System, Charlottesville, VA 22908 0708, USA
Biochim Biophys Acta 1728:1-10. 2005.... - Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylaseFan Yeung
Department of Biochemistry and Molecular Genetics, The University of Virginia, Charlottesville, VA 22908, USA
EMBO J 23:2369-80. 2004.... - Identification of a negative regulatory cis-element in the enhancer core region of the prostate-specific antigen promoter: implications for intersection of androgen receptor and nuclear factor-kappaB signalling in prostate cancer cellsBekir Cinar
Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Biochem J 379:421-31. 2004..Collectively, these data indicate that cross-modulation between AR and NF-kappaB p65 transcription factors may occur by a novel mechanism involving binding to a common cis -DNA element... - IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300Jamie E Hoberg
Department of Biochemistry and Molecular Genetics, Box 800733, University of Virginia, Charlottesville, Virginia 22908, USA
Mol Cell Biol 26:457-71. 2006.... - LZAP, a putative tumor suppressor, selectively inhibits NF-kappaBJialiang Wang
Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA
Cancer Cell 12:239-51. 2007..In aggregate, these data support a role of LZAP in NF-kappaB regulation and tumor suppression... - Aberrant cytoplasmic localization of N-CoR in colorectal tumorsVanessa Fernández-Majada
Centre Oncologia Molecular, Institut d Investigacio Biomedica de Bellvitge, Hospitalet, Barcelona, Spain
Cell Cycle 6:1748-52. 2007..Moreover, we have analyzed the subcellular localization of N-CoR in 43 colorectal cancer samples and we have found that aberrant cytoplasmic distribution of N-CoR is a general trait of these tumors... - COMMD proteins, a novel family of structural and functional homologs of MURR1Ezra Burstein
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
J Biol Chem 280:22222-32. 2005....
Research Grants
- Antiapoptotic Role of NF-kB in Calcium SignalingMARTY MAYO; Fiscal Year: 2003....
- Inflammatory Cytokines Link NF-kappaB with Bim Degradation and MetastasisMarty W Mayo; Fiscal Year: 2010..Understanding the mechanisms used by inflammatory mediators to stimulate Bim degradation will potentially result in the identification of novel approaches to preventing NSCLC metastasis. ..
- Role of IKK in NSCLC Modulation of SMRT and NF-kappabMARTY MAYO; Fiscal Year: 2007..This new understanding would provide a useful NSCLC marker and would potentially identify an important molecular target that may result in novel treatment strategies for this deadly disease. ..
- Antiapoptotic Role of NF-kB in Calcium SignalingMARTY MAYO; Fiscal Year: 2007..abstract_text> ..
- Antiapoptotic Role of NF-kB in Calcium SignalingMARTY MAYO; Fiscal Year: 2006..abstract_text> ..
- ONCOGENIC RAS REQUIRES NFKB ANTIAPOPTOTIC FUNCTIONMARTY MAYO; Fiscal Year: 2003..These studies will elucidate the mechanisms by which NF kappa B provides protection against apoptosis in response to oncogenic Ras and will potentially provide new insight into the development of anticancer therapies. ..
- Role of IKK in NSCLC: Modulation of SMRT and NF-kappaBMarty W Mayo; Fiscal Year: 2010..The overall goal of this project is use these newly identified gene products as novel therapeutic targets for detection and treatment of NSCLC. ..