ROY MAYFIELD

Summary

Affiliation: University of Texas
Country: USA

Publications

  1. pmc Chronic self-administration of alcohol results in elevated ΔFosB: comparison of hybrid mice with distinct drinking patterns
    ANGELA R OZBURN
    Waggoner Center for Alcoholism and Addiction Research, Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    BMC Neurosci 13:130. 2012
  2. ncbi request reprint Dopamine D2 receptor regulation of the dopamine transporter expressed in Xenopus laevis oocytes is voltage-independent
    R D Mayfield
    Department of Pharmacology and Neuroscience Program, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Mol Pharmacol 59:113-21. 2001
  3. ncbi request reprint Ethanol potentiates the function of the human dopamine transporter expressed in Xenopus oocytes
    R D Mayfield
    Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, Texas 78712, USA
    J Neurochem 79:1070-9. 2001
  4. ncbi request reprint Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics
    R Dayne Mayfield
    Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, TX 78712, USA
    J Neurochem 81:802-13. 2002
  5. ncbi request reprint Methods for the identification of differentially expressed genes in human post-mortem brain
    R Dayne Mayfield
    Department of Psychology, Waggoner Center for Alcohol and Addiction Research, Molecular Biology Building 1 124, University of Texas at Austin, Austin, TX 78712, USA
    Methods 31:301-5. 2003
  6. ncbi request reprint G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action
    J M Lewohl
    Waggoner Center for Alcohol and Addiction Research and Section on Neurobiology, University of Texas at Austin, Austin, Texas 78712, USA
    Nat Neurosci 2:1084-90. 1999
  7. ncbi request reprint Functional uncoupling of adenosine A(2A) receptors and reduced responseto caffeine in mice lacking dopamine D2 receptors
    N R Zahniser
    Department of Pharmacology and Neuroscience Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurosci 20:5949-57. 2000
  8. ncbi request reprint Defining the dopamine transporter proteome by convergent biochemical and in silico analyses
    R Maiya
    Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Genes Brain Behav 6:97-106. 2007
  9. pmc Genetic factors influencing alcohol dependence
    R D Mayfield
    Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, TX 78712, USA
    Br J Pharmacol 154:275-87. 2008
  10. ncbi request reprint Gene expression profiling of individual cases reveals consistent transcriptional changes in alcoholic human brain
    Jianwen Liu
    Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas 78712, USA
    J Neurochem 90:1050-8. 2004

Collaborators

Detail Information

Publications18

  1. pmc Chronic self-administration of alcohol results in elevated ΔFosB: comparison of hybrid mice with distinct drinking patterns
    ANGELA R OZBURN
    Waggoner Center for Alcoholism and Addiction Research, Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    BMC Neurosci 13:130. 2012
    ..In the present study, we tested the hypothesis that these phenotypes are represented by differential production of the inducible transcription factor, ΔFosB, in reward, aversion, and stress related brain regions...
  2. ncbi request reprint Dopamine D2 receptor regulation of the dopamine transporter expressed in Xenopus laevis oocytes is voltage-independent
    R D Mayfield
    Department of Pharmacology and Neuroscience Program, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Mol Pharmacol 59:113-21. 2001
    ..These results suggest that D2R-induced up-regulation of DAT activity occurs via a voltage-independent mechanism that depends on G(i/o) activation and a rapid increase in expression of functional DAT molecules at the cell surface...
  3. ncbi request reprint Ethanol potentiates the function of the human dopamine transporter expressed in Xenopus oocytes
    R D Mayfield
    Waggoner Center for Alcohol and Addiction Research, University of Texas, Austin, Texas 78712, USA
    J Neurochem 79:1070-9. 2001
    ..A potential mechanism by which ethanol acts to enhance DAT function may involve regulation of DAT expression on the cell surface...
  4. ncbi request reprint Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics
    R Dayne Mayfield
    Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, TX 78712, USA
    J Neurochem 81:802-13. 2002
    ..These results suggest that multiple pathways may be important for neuropathology and altered neuronal function observed in alcoholism...
  5. ncbi request reprint Methods for the identification of differentially expressed genes in human post-mortem brain
    R Dayne Mayfield
    Department of Psychology, Waggoner Center for Alcohol and Addiction Research, Molecular Biology Building 1 124, University of Texas at Austin, Austin, TX 78712, USA
    Methods 31:301-5. 2003
    ..This technical report describes the basic methodology and analyses used to identify such genes in human post-mortem brain tissue...
  6. ncbi request reprint G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action
    J M Lewohl
    Waggoner Center for Alcohol and Addiction Research and Section on Neurobiology, University of Texas at Austin, Austin, Texas 78712, USA
    Nat Neurosci 2:1084-90. 1999
    ..GIRK2/IRK1 chimeras and GIRK2 truncation mutants were used to identify a region of 43 amino acids in the carboxyl (C) terminus that is critical for the action of ethanol on these channels...
  7. ncbi request reprint Functional uncoupling of adenosine A(2A) receptors and reduced responseto caffeine in mice lacking dopamine D2 receptors
    N R Zahniser
    Department of Pharmacology and Neuroscience Program, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Neurosci 20:5949-57. 2000
    ..They also reinforce the ideas that D(2)Rs and A(2A)Rs are functionally opposed and that D(2)R-mediated effects normally predominate...
  8. ncbi request reprint Defining the dopamine transporter proteome by convergent biochemical and in silico analyses
    R Maiya
    Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Genes Brain Behav 6:97-106. 2007
    ..In summary, this study identified a network of proteins that are primary candidates for functional regulation of the DAT, an important player in mechanisms of mental disorders and drug addiction...
  9. pmc Genetic factors influencing alcohol dependence
    R D Mayfield
    Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, TX 78712, USA
    Br J Pharmacol 154:275-87. 2008
    ..Moreover, the information offered here addresses the importance of more general issues regarding genetics and gene expression related to alcohol abuse and dependence...
  10. ncbi request reprint Gene expression profiling of individual cases reveals consistent transcriptional changes in alcoholic human brain
    Jianwen Liu
    Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas 78712, USA
    J Neurochem 90:1050-8. 2004
    ..Importantly, hierarchical clustering of differentially expressed genes accurately distinguished between control and alcoholic cases, particularly in the frontal cortex...
  11. ncbi request reprint Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals
    Jianwen Liu
    Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, TX 78712, USA
    Neuropsychopharmacology 31:1574-82. 2006
    ..These results revealed a consistent re-programming of gene expression in alcohol abusers that reliably discriminates alcoholic from non-alcoholic individuals...
  12. pmc Neuroadaptations in human chronic alcoholics: dysregulation of the NF-kappaB system
    Anna Okvist
    The Section of Alcohol and Drug Dependence Research, Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden
    PLoS ONE 2:e930. 2007
    ..Here we investigated whether transcription factors of Nuclear Factor-kappaB (NF-kappaB) family, controlling neuronal plasticity and neurodegeneration, are involved in these adaptations in human chronic alcoholics...
  13. ncbi request reprint Altered gene expression profiles in the frontal cortex of cirrhotic alcoholics
    Jianwen Liu
    Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas 78712, USA
    Alcohol Clin Exp Res 31:1460-6. 2007
    ..Heavy alcohol use results in brain damage that is generally more severe in cirrhotic compared with noncirrhotic alcoholics. We examined, at the cellular level, gene expression in the frontal cortex of cirrhotic alcoholics...
  14. pmc Ethanol potentiates dopamine uptake and increases cell surface distribution of dopamine transporters expressed in SK-N-SH and HEK-293 cells
    D Nicole Riherd
    Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, TX 78712, USA
    Alcohol 42:499-508. 2008
    ..Our findings demonstrate ethanol's action on DAT function and regulation is consistent across multiple model systems...
  15. ncbi request reprint Ethanol-sensitive sites on the human dopamine transporter
    Rajani Maiya
    Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, 2500 Speedway, Austin, TX 78712, USA
    J Biol Chem 277:30724-9. 2002
    ..These results identify novel sites in the second intracellular loop that are important for ethanol modulation of DAT activity...
  16. ncbi request reprint The application of proteomics to the human alcoholic brain
    Joanne M Lewohl
    Department of Biochemistry, University of Queensland, Brisbane 4072, Australia
    Ann N Y Acad Sci 1025:14-26. 2004
    ..The finding that the expression level of differentially expressed proteins is preponderantly lower in the alcoholic brain is supported by recent results from parallel studies using microarray mRNA transcript...
  17. ncbi request reprint Ethanol-induced Fos immunoreactivity in the extended amygdala and hypothalamus of the rat brain: focus on cholinergic interneurons of the nucleus accumbens
    Bruce E Herring
    Department of Psychology, University of Texas at Austin, Austin, Texas 78712 0187, USA
    Alcohol Clin Exp Res 28:588-97. 2004
    ..The cholinergic interneurons of the nucleus accumbens were of particular interest, because these cells have recently been reported to play a pivotal role in substance abuse...
  18. ncbi request reprint Dopamine transporter network and pathways
    Rajani Maiya
    Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Int Rev Neurobiol 61:79-96. 2004

Research Grants6

  1. The dopamine transporter: a novel site of ethanol action
    ROY MAYFIELD; Fiscal Year: 2007
    ..Third, the DAT proteome has not been studied, and defining this important complex will be an innovative accomplishment which should have wide ranging significance for other areas of neurobiology and addiction research. ..
  2. Alcohol-responsive protein networks underlying excessive ethanol consumption
    ROY MAYFIELD; Fiscal Year: 2007
    ..The resulting changes in trafficking, targeting, and synaptic function underlie ethanol-related phenotypes. ..