Emeran Mayer

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The brain-gut axis in abdominal pain syndromes
    Emeran A Mayer
    Center for Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Annu Rev Med 62:381-96. 2011
  2. pmc Sex-related differences of cortical thickness in patients with chronic abdominal pain
    Zhiguo Jiang
    Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress and Pain and Interoception Network PAIN Repository, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America Human Performance and Engineering Laboratory, Kessler Foundation Research Center, West Orange, New Jersey, United States of America Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, New Jersey, United States of America
    PLoS ONE 8:e73932. 2013
  3. pmc Brain-gut microbiome interactions and functional bowel disorders
    Emeran A Mayer
    Oppenheimer Center for Neurobiology of Stress, Division of Digestive Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California Electronic address
    Gastroenterology 146:1500-12. 2014
  4. pmc Differences in brain responses between lean and obese women to a sweetened drink
    L Connolly
    Oppenheimer Family Center for Neurobiology of Stress, Los Angeles, CA 90095 7378, USA
    Neurogastroenterol Motil 25:579-e460. 2013
  5. doi request reprint An update on the use and investigation of probiotics in health and disease
    Mary Ellen Sanders
    Dairy and Food Culture Technologies, Centennial, Colorado, USA
    Gut 62:787-96. 2013
  6. ncbi request reprint Inflammation in irritable bowel syndrome: curiosity or culprit
    Emeran A Mayer
    Center of Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Building 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    J Pediatr Gastroenterol Nutr 39:S751-3. 2004
  7. ncbi request reprint Neuroimaging of the brain-gut axis: from basic understanding to treatment of functional GI disorders
    Emeran A Mayer
    Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Los Angeles, California 90073, USA
    Gastroenterology 131:1925-42. 2006
  8. ncbi request reprint Current insights into the pathophysiology of irritable bowel syndrome
    Ines Schwetz
    Center of Neurovisceral Sciences and Women s Health, CURE Digestive Diseases Research Center, David Geffen School of Medicine at UCLA, VAGLAHS, Bldg 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Curr Gastroenterol Rep 5:331-6. 2003
  9. pmc Brain imaging approaches to the study of functional GI disorders: a Rome working team report
    E A Mayer
    Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA 90073, USA
    Neurogastroenterol Motil 21:579-96. 2009
  10. ncbi request reprint Differences in brain responses to visceral pain between patients with irritable bowel syndrome and ulcerative colitis
    Emeran A Mayer
    Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
    Pain 115:398-409. 2005

Detail Information

Publications82

  1. pmc The brain-gut axis in abdominal pain syndromes
    Emeran A Mayer
    Center for Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Annu Rev Med 62:381-96. 2011
    ....
  2. pmc Sex-related differences of cortical thickness in patients with chronic abdominal pain
    Zhiguo Jiang
    Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress and Pain and Interoception Network PAIN Repository, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America Human Performance and Engineering Laboratory, Kessler Foundation Research Center, West Orange, New Jersey, United States of America Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, New Jersey, United States of America
    PLoS ONE 8:e73932. 2013
    ..We aimed to characterize regional changes in cortical thickness (CT) in a large number of well phenotyped IBS patients, taking into account the role of sex related differences...
  3. pmc Brain-gut microbiome interactions and functional bowel disorders
    Emeran A Mayer
    Oppenheimer Center for Neurobiology of Stress, Division of Digestive Diseases, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California Electronic address
    Gastroenterology 146:1500-12. 2014
    ..Studies are needed to better characterize alterations to the intestinal microbiome in large cohorts of well-phenotyped patients, and to correlate intestinal metabolites with specific abnormalities in gut-brain interactions...
  4. pmc Differences in brain responses between lean and obese women to a sweetened drink
    L Connolly
    Oppenheimer Family Center for Neurobiology of Stress, Los Angeles, CA 90095 7378, USA
    Neurogastroenterol Motil 25:579-e460. 2013
    ....
  5. doi request reprint An update on the use and investigation of probiotics in health and disease
    Mary Ellen Sanders
    Dairy and Food Culture Technologies, Centennial, Colorado, USA
    Gut 62:787-96. 2013
    ....
  6. ncbi request reprint Inflammation in irritable bowel syndrome: curiosity or culprit
    Emeran A Mayer
    Center of Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Building 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    J Pediatr Gastroenterol Nutr 39:S751-3. 2004
  7. ncbi request reprint Neuroimaging of the brain-gut axis: from basic understanding to treatment of functional GI disorders
    Emeran A Mayer
    Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Los Angeles, California 90073, USA
    Gastroenterology 131:1925-42. 2006
  8. ncbi request reprint Current insights into the pathophysiology of irritable bowel syndrome
    Ines Schwetz
    Center of Neurovisceral Sciences and Women s Health, CURE Digestive Diseases Research Center, David Geffen School of Medicine at UCLA, VAGLAHS, Bldg 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Curr Gastroenterol Rep 5:331-6. 2003
    ....
  9. pmc Brain imaging approaches to the study of functional GI disorders: a Rome working team report
    E A Mayer
    Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA 90073, USA
    Neurogastroenterol Motil 21:579-96. 2009
    ..The article concludes with a critical assessment of published studies, and with recommendations for improved study paradigms and analysis strategies...
  10. ncbi request reprint Differences in brain responses to visceral pain between patients with irritable bowel syndrome and ulcerative colitis
    Emeran A Mayer
    Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
    Pain 115:398-409. 2005
    ....
  11. ncbi request reprint Alosetron and irritable bowel syndrome
    Emeran A Mayer
    Center for Neurovisceral Sciences and Women s Health, VAGLAHS, Bldg 115 CURE 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
    Expert Opin Pharmacother 4:2089-98. 2003
    ..The impact of alosetron on QOL in IBS patients and the safety of treatment with alosetron, will also be covered...
  12. pmc Functional GI disorders: from animal models to drug development
    E A Mayer
    UCLA Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Gut 57:384-404. 2008
    ....
  13. pmc Clinical practice. Irritable bowel syndrome
    Emeran A Mayer
    Center for Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6949, USA
    N Engl J Med 358:1692-9. 2008
  14. ncbi request reprint Approaches to the modulation of abdominal pain
    E A Mayer
    UCLA CURE Neuroenteric Disease Program, Department of Medicine, Physiology and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90073, USA
    Can J Gastroenterol 13:65A-70A. 1999
    ....
  15. ncbi request reprint Sex-based differences in gastrointestinal pain
    Emeran A Mayer
    Departments of Medicine, Psychiatry and Biobehavioral Sciences, CNS Center for Neurovisceral Sciences and Women s Health, UCLA Division of Digestive Diseases, UCLA and VA GLAHS, WLA VA Medical Center, Los Angeles, CA 90073, USA
    Eur J Pain 8:451-63. 2004
    ..Consistent with experimental findings in animals, current evidence is consistent with a pathophysiological model which emphasizes sex-related differences in autonomic and antinociceptive responses to certain visceral stimuli...
  16. pmc Gut feelings: the emerging biology of gut-brain communication
    Emeran A Mayer
    Center for Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CHS 47 122 10833 Le Conte Avenue, Los Angeles, California 90095 7378, USA
    Nat Rev Neurosci 12:453-66. 2011
    ..Moreover, disturbances of this system have been implicated in a wide range of disorders, including functional and inflammatory gastrointestinal disorders, obesity and eating disorders...
  17. ncbi request reprint V. Stress and irritable bowel syndrome
    E A Mayer
    UCLA CURE Neuroenteric Disease Program, Departments of Medicine, Physiology, and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California 90024, USA
    Am J Physiol Gastrointest Liver Physiol 280:G519-24. 2001
    ..Functional brain imaging techniques are beginning to identify brain circuits involved in the perceptual alterations. Animal models have recently been proposed that mimic key features of the human syndrome...
  18. ncbi request reprint Evolving pathophysiologic models of functional gastrointestinal disorders
    Emeran A Mayer
    CURE Neuroenteric Disease Program, UCLA Division of Digestive Diseases and Brain Research Institute, Los Angeles, California 90073, USA
    Gastroenterology 122:2032-48. 2002
    ..Future development of existing and novel models involves the use of transgenic and knockout animals, as well as the demonstration of predictive validity in terms of responsiveness to candidate drugs...
  19. ncbi request reprint Depression, anxiety, and the gastrointestinal system
    E A Mayer
    Department of Medicine, University of California, Los Angeles, USA
    J Clin Psychiatry 62:28-36; discussion 37. 2001
    ....
  20. ncbi request reprint The effect of the 5-HT3 receptor antagonist, alosetron, on brain responses to visceral stimulation in irritable bowel syndrome patients
    E A Mayer
    CURE Digestive Diseases Research Center Neuroenteric Disease Program, Department of Medicine, University of California School of Medicine, Los Angeles, CA 90073, USA
    Aliment Pharmacol Ther 16:1357-66. 2002
    ....
  21. ncbi request reprint Basic pathophysiologic mechanisms in irritable bowel syndrome
    E A Mayer
    UCLA CURE Neuroenteric Disease Program, Department of Medicine, Physiology and Biobehavioral Sciences, UCLA School of Medicine, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Dig Dis 19:212-8. 2001
    ..IBS patients show an enhanced responsiveness of this system manifesting in altered modulation of gastrointestinal motility, secretion, immune function and in alterations in the perceptual and emotional response to visceral events...
  22. ncbi request reprint Commentary on peripheral and central contributions to hyperalgesia in irritable bowel syndrome
    Emeran A Mayer
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, Physiology, and Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    J Pain 7:539-41; discussion 542-3. 2006
  23. ncbi request reprint Review article: modulation of the brain-gut axis as a therapeutic approach in gastrointestinal disease
    E A Mayer
    Department of Medicine, Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Aliment Pharmacol Ther 24:919-33. 2006
    ..Numerous current and emerging therapies aimed at normalizing brain-gut interactions are a focus of interest, particularly for irritable bowel syndrome and functional dyspepsia...
  24. ncbi request reprint The evolving neurobiology of gut feelings
    E A Mayer
    Department of Medicine and Physiology, UCLA School of Medicine 90024, USA
    Prog Brain Res 122:195-206. 2000
    ..Alterations in this bi-directional process such as peripheral pathologies within the gut or alterations at the brain level may explain the close association between certain affective disorders and functional visceral syndromes...
  25. ncbi request reprint Review article: gender-related differences in functional gastrointestinal disorders
    E A Mayer
    CURE Neuroenteric Disease Program, UCLA Division of Digestive Diseases, USA
    Aliment Pharmacol Ther 13:65-9. 1999
    ....
  26. pmc Diffusion tensor imaging detects microstructural reorganization in the brain associated with chronic irritable bowel syndrome
    Benjamin M Ellingson
    Department of Radiological Science, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA
    Pain 154:1528-41. 2013
    ....
  27. ncbi request reprint Emerging drugs for irritable bowel syndrome
    Sylvie Bradesi
    Center for Neurovisceral Sciences and Women s Health, CURE Digestive Diseases Research Center, UCLA Division of Digestive Diseases, GLA VA HC Bldg, 115 CURE, 11301 Wilshire Blvd, Los Angeles, California 90073, USA
    Expert Opin Emerg Drugs 11:293-313. 2006
    ..Advances in clinical trial design will help to evaluate these compounds in different IBS patient populations...
  28. ncbi request reprint Proximal colon distention increases Fos expression in the lumbosacral spinal cord and activates sacral parasympathetic NADPHd-positive neurons in rats
    V Martinez
    Department of Medicine, CURE Digestive Diseases Research Center, West Los Angeles VA Medical Center, California 90073, USA
    J Comp Neurol 390:311-21. 1998
    ..The marked activation of NADPHd-positive neurons in the sacral parasympathetic nucleus suggests a possible role of nitric oxide in the visceroautonomic reflexes induced by distention of the proximal colon...
  29. pmc Measuring irritable bowel syndrome patient-reported outcomes with an abdominal pain numeric rating scale
    B Spiegel
    VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
    Aliment Pharmacol Ther 30:1159-70. 2009
    ..Pain numeric rating scales (NRS) are widely used in the non-IBS pain literature. The Food and Drug Administration has proposed using the NRS in IBS...
  30. pmc Developing valid and reliable health utilities in irritable bowel syndrome: results from the IBS PROOF Cohort
    Brennan Spiegel
    VA Greater Los Angeles Healthcare System UCLA, Digestive Diseaes, 11301 Wilshire Blvd, Building 11, Room 21E, Los Angeles, California 90073, USA
    Am J Gastroenterol 104:1984-91. 2009
    ..To inform future cost-utility analyses in IBS, we measured and validated the IBS utilities...
  31. pmc The perfect neuroimaging-genetics-computation storm: collision of petabytes of data, millions of hardware devices and thousands of software tools
    Ivo D Dinov
    Laboratory of Neuro Imaging LONI, David Geffen School of Medicine at UCLA, University of California, Los Angeles, 635 S Charles Young Drive, Suite 225, Los Angeles, CA, 90095 7334, USA
    Brain Imaging Behav 8:311-22. 2014
    ..These are implemented as graphical workflow protocols in the context of analyzing imaging (sMRI, fMRI, DTI), phenotypic (demographic, clinical), and genetic (SNP) data. ..
  32. ncbi request reprint The impact of somatization on the use of gastrointestinal health-care resources in patients with irritable bowel syndrome
    Brennan M R Spiegel
    Division of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Am J Gastroenterol 100:2262-73. 2005
    ..We sought to determine whether higher levels of somatization are associated with higher levels of gastrointestinal (GI) resource utilization in IBS...
  33. ncbi request reprint Dual role of 5-HT3 receptors in a rat model of delayed stress-induced visceral hyperalgesia
    Sylvie Bradesi
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, VAGLAHS CURE Building 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Pain 130:56-65. 2007
    ..In addition, we showed that stress-induced sensitization of visceral nociception is independent of 5-HT3R activation on vagal afferents...
  34. pmc Regional brain activation in conscious, nonrestrained rats in response to noxious visceral stimulation
    Zhuo Wang
    Center for the Neurobiology of Stress, Brain Research Institute, UCLA, Los Angeles, CA, USA
    Pain 138:233-43. 2008
    ..This suggests that functional brain imaging captures more extensive responses of the central nervous system to noxious visceral distension than those identified by traditional measures...
  35. ncbi request reprint Longitudinal change in perceptual and brain activation response to visceral stimuli in irritable bowel syndrome patients
    Bruce D Naliboff
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Gastroenterology 131:352-65. 2006
    ..Repeated stimulus exposure leads to decreased salience of threat and reduction of hypervigilance. We sought to evaluate hypervigilance in IBS visceral hypersensitivity and associated brain activity...
  36. ncbi request reprint The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in rats
    Sylvie Bradesi
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    Gastroenterology 130:1729-42. 2006
    ..Here we examined the participation of NK(1)Rs in sustained visceral hyperalgesia observed in rats exposed to chronic psychological stress...
  37. ncbi request reprint Condition-specific deactivation of brain regions by 5-HT3 receptor antagonist Alosetron
    Steven M Berman
    CURE Neuroenteric Disease Program, Department of Medicine, University of California School of Medicine, Los Angeles, California 90073, USA
    Gastroenterology 123:969-77. 2002
    ....
  38. ncbi request reprint The central role of gastrointestinal-specific anxiety in irritable bowel syndrome: further validation of the visceral sensitivity index
    Jennifer S Labus
    Department of Psychiatry and Biobehavioral Sciences, Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Psychosom Med 69:89-98. 2007
    ....
  39. pmc Predictors of patient-assessed illness severity in irritable bowel syndrome
    Brennan Spiegel
    VA Greater Los Angeles Healthcare System, Center for Outcomes Research and Education, Los Angeles, California, USA
    Am J Gastroenterol 103:2536-43. 2008
    ..Since severity is a patient-centered outcome, it is essential that future instruments are based on patients' self-perceptions of severity. We measured patient-derived predictors of severity in a large cohort of IBS patients...
  40. pmc Psychometric properties of the Early Trauma Inventory-Self Report
    J Douglas Bremner
    Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia 30306, USA
    J Nerv Ment Dis 195:211-8. 2007
    ..These findings suggest that the ETI-SR is a valid measure of early trauma, and suggest future directions for a shortened version of the ETI-SR that could be more easily incorporated into clinical research studies and practice settings...
  41. pmc Studying sex and gender differences in pain and analgesia: a consensus report
    Joel D Greenspan
    Department of Biomedical Sciences, University of Maryland Dental School, University of Maryland, Baltimore, MD 21201 1510, USA
    Pain 132:S26-45. 2007
    ..as a utilitarian and thought-provoking guide for future research on sex and gender differences in pain and analgesia, both for those currently working in this field as well as those still wondering, "Do I really need to study females?"..
  42. doi request reprint Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in rats
    Muriel Larauche
    Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1033-40. 2008
    ..These data support a major role for CRF(1) in both the development and maintenance of visceral hyperalgesia induced by repeated stress and indicate a possible role of peripheral CRF receptors in such mechanisms...
  43. doi request reprint Effect of abuse history on pain reports and brain responses to aversive visceral stimulation: an FMRI study
    Yehuda Ringel
    UNC Center for Functional GI and Motility Disorders, University of North Carolina, Chapel Hill, North Carolina, USA
    Gastroenterology 134:396-404. 2008
    ..These effects may be mediated by enhanced responses to aversive visceral stimuli. We investigated the effects of IBS and abuse history on pain reporting and brain activation in response to rectal distentions...
  44. doi request reprint The effect of auditory stress on perception of intraesophageal acid in patients with gastroesophageal reflux disease
    Ronnie Fass
    The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and Arizona Health Sciences Center, Tucson, Arizona, USA
    Gastroenterology 134:696-705. 2008
    ..We sought to determine the effect of an acute laboratory stressor on perceptual and emotional responses to intraesophageal acid perfusion in healthy controls and patients with GERD...
  45. doi request reprint Reduced brainstem inhibition during anticipated pelvic visceral pain correlates with enhanced brain response to the visceral stimulus in women with irritable bowel syndrome
    Steven M Berman
    Department of Medicine, University of California, Los Angeles Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at University of California, Los Angeles, 90073, USA
    J Neurosci 28:349-59. 2008
    ....
  46. ncbi request reprint Enteric neuroscience: the dawn of a new discipline
    Emeran A Mayer
    Gastroenterology 132:1217-8. 2007
  47. ncbi request reprint Sex differences in regional brain response to aversive pelvic visceral stimuli
    Steven M Berman
    University of California, Los Angeles UCLA, Center for Neurovisceral Sciences and Women s Health, Department of Medicine, and Veterans Affairs Greater Los Angeles Healthcare System, CA 90073, USA
    Am J Physiol Regul Integr Comp Physiol 291:R268-76. 2006
    ..Greater familiarity of females with physiological pelvic visceral discomfort may have enhanced brain systems that dampen arousal networks during lower levels of discomfort...
  48. ncbi request reprint Clinical determinants of health-related quality of life in patients with irritable bowel syndrome
    Brennan M R Spiegel
    Division of Gastroenterology, the VA Greater Los Angeles Healthcare System, CA 90073, USA
    Arch Intern Med 164:1773-80. 2004
    ..The identification of predictive factors could allow physicians to better assess HRQOL without using misleading clinical clues. We, therefore, sought to identify determinants of HRQOL in patients with IBS...
  49. ncbi request reprint The effect of life stress on symptoms of heartburn
    Bruce D Naliboff
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, UCLA, Los Angeles, CA, USA
    Psychosom Med 66:426-34. 2004
    ..The present longitudinal study tests the general hypothesis that life stressors can exacerbate symptoms in patients with chronic heartburn...
  50. ncbi request reprint Electrophysiological characterization of N-methyl-D-aspartate receptors in rat dorsal root ganglia neurons
    Jichang Li
    Division of Digestive Diseases, Department of Medicine, Center for Neurovisceral Sciences CNS and Women s Health, University of California, Warren Hall, Room 14 103, 900 Veterans Avenue, Los Angeles, CA 90095, USA
    Pain 109:443-52. 2004
    ..These results demonstrate that functional NMDARs expressed by DRG neurons innervating both somatic and visceral tissues of adult rats are composed predominantly of NR2B subunits...
  51. ncbi request reprint Is there a difference between abdominal pain and discomfort in moderate to severe IBS patients?
    Joel Sach
    C N S Center for Neurovisceral Sciences and Women s Health, Los Angeles, California, USA
    Am J Gastroenterol 97:3131-8. 2002
    ....
  52. ncbi request reprint The neural correlates of placebo effects: a disruption account
    Matthew D Lieberman
    Department of Psychology, University of California Los Angeles, Franz Hall, 405 Hilgard Avenue, Los Angeles, CA 90095 1563, USA
    Neuroimage 22:447-55. 2004
    ..This is the first study to identify a neural pathway from a region of the brain associated with placebos and affective thought to a region closely linked to the placebo-related outcome of diminished pain unpleasantness...
  53. ncbi request reprint Collaborative health for IBS
    Emeran A Mayer
    Clin Gastroenterol Hepatol 1:423-4. 2003
  54. ncbi request reprint Irritable bowel syndrome patients show enhanced modulation of visceral perception by auditory stress
    Britta Dickhaus
    University of California, Department of Medicine, Los Angeles UCLA CNS Center for Neurovisceral Sciences and Women s Health, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
    Am J Gastroenterol 98:135-43. 2003
    ..The aim of this study was to test the primary hypothesis that IBS patients show altered perceptual responses to rectal balloon distention during experimentally induced psychological stress compared with healthy control subjects...
  55. ncbi request reprint Prevalence of irritable bowel syndrome among university students: the roles of worry, neuroticism, anxiety sensitivity and visceral anxiety
    Holly Hazlett-Stevens
    Department of Psychology 298, University of Nevada, Reno, NV 89557, USA
    J Psychosom Res 55:501-5. 2003
    ..Relationships between presence of irritable bowel syndrome (IBS) and generalized anxiety disorder (GAD), chronic worry, neuroticism, anxiety sensitivity and anxiety about visceral sensations were examined among university students...
  56. ncbi request reprint Delayed stress-induced colonic hypersensitivity in male Wistar rats: role of neurokinin-1 and corticotropin-releasing factor-1 receptors
    Ines Schwetz
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Gaffen School of Medicine ar University of California, Los Angeles 90024, USA
    Am J Physiol Gastrointest Liver Physiol 286:G683-91. 2004
    ..Chemical sympathectomy did not affect delayed SICH. Our results indicate that in male Wistar rats, both NK(1)R and CRF(1)R activation, but not sympathetic nervous system activation, play a role in the development of SICH...
  57. ncbi request reprint Sex-related differences in IBS patients: central processing of visceral stimuli
    Bruce D Naliboff
    Center for Neurovisceral Sciences and Women s Health, UCLA School of Medicine, CURE Building, 115 Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Gastroenterology 124:1738-47. 2003
    ..The aim of this study was to determine possible sex-related differences in brain responses to a visceral and a psychological stressor in IBS...
  58. ncbi request reprint A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats
    Mulugeta Million
    CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health CNS, West Los Angeles VA Medical Center, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90073, USA
    Brain Res 985:32-42. 2003
    ....
  59. ncbi request reprint Racial differences in the impact of irritable bowel syndrome on health-related quality of life
    Ian M Gralnek
    VA Greater Los Angeles Health Care System, Los Angeles, CA, USA
    J Clin Gastroenterol 38:782-9. 2004
    ..To compare the impact of irritable bowel syndrome (IBS) on health related quality of life (HRQOI) for non-white and white IBS patients...
  60. ncbi request reprint A dose-ranging, phase II study of the efficacy and safety of alosetron in men with diarrhea-predominant IBS
    Lin Chang
    Center for Neurovisceral Sciences and Women s Health, UCLA Division of Digestive Diseases, Los Angeles, California, USA
    Am J Gastroenterol 100:115-23. 2005
    ..A randomized, double blind, placebo-controlled dose-ranging study was conducted to assess the efficacy of alosetron in men with diarrhea-predominant irritable bowel syndrome (IBS)...
  61. ncbi request reprint Two N-methyl-D-aspartate receptors in rat dorsal root ganglia with different subunit composition and localization
    Juan Carlos G Marvizon
    Neuroenteric Disease Program, CURE Digestive Diseases Research Center, Department of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 446:325-41. 2002
    ....
  62. ncbi request reprint Effect of sex on perception of rectosigmoid stimuli in irritable bowel syndrome
    Lin Chang
    Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, and Veterans Affairs Greater Los Angeles Healthcare System, California 90073, USA
    Am J Physiol Regul Integr Comp Physiol 291:R277-84. 2006
    ..01), while men did not. Sex significantly influences perceptual sensitivity to rectosigmoid distension. Women show greater perceptual responses to this paradigm...
  63. ncbi request reprint Experimental colitis modulates the functional properties of NMDA receptors in dorsal root ganglia neurons
    Jichang Li
    Department of Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Am J Physiol Gastrointest Liver Physiol 291:G219-28. 2006
    ..In conclusion, colonic inflammation upregulates the activity of NMDARs in all DRG neurons within ganglia innervating this tissue through mechanisms involving increased expression and persistent tyrosine phosphorylation...
  64. ncbi request reprint Effect of transient chemically induced colitis on the visceromotor response to mechanical colorectal distension
    Jürgen M Gschossmann
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Eur J Gastroenterol Hepatol 14:1067-72. 2002
    ..Acute mucosal inflammation may initiate alterations of visceral sensory function. However, experimental studies on the potential effects of a transient inflammation on visceral sensitivity are lacking...
  65. ncbi request reprint Is a negative colonoscopy associated with reassurance or improved health-related quality of life in irritable bowel syndrome?
    Brennan M R Spiegel
    Division of Gastroenterology, VA Greater Los Angeles Healthcare System, CA 90073, USA
    Gastrointest Endosc 62:892-9. 2005
    ..However, no previous data have measured these effects. We sought to measure the association of a normal colonoscopy with reassurance and HRQOL in patients with IBS aged <50 years...
  66. ncbi request reprint Pain perception in irritable bowel syndrome
    Kirsten Tillisch
    Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine, University of California Los Angeles, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    CNS Spectr 10:877-82. 2005
    ..The frequent comorbidity with psychiatric disorders suggests the possibility of shared pathophysiological mechanisms and etiologic factors...
  67. ncbi request reprint Corticotropin-releasing factor receptor 1 mediates acute and delayed stress-induced visceral hyperalgesia in maternally separated Long-Evans rats
    Ines Schwetz
    Center for Neurovisceral Sciences and Women s Health, University of California Los Angeles, CA 90073, USA
    Am J Physiol Gastrointest Liver Physiol 289:G704-12. 2005
    ..Both acute and delayed stress-induced visceral hypersensitivity in MS rats are mediated by the CRF/CRF(1)R system...
  68. ncbi request reprint Characterization of the alternating bowel habit subtype in patients with irritable bowel syndrome
    Kirsten Tillisch
    CNS WH Center for Neurovisceral Sciences and Women s Health, Department of Medicine, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
    Am J Gastroenterol 100:896-904. 2005
    ..Due to a wide range of symptom patterns, patients with irritable bowel syndrome (IBS) are often subgrouped by bowel habit. However, the IBS subgroup with alternating bowel habits (IBS-A) has been poorly characterized...
  69. ncbi request reprint Impact of irritable bowel syndrome on patients' lives: development and psychometric documentation of a disease-specific measure for use in clinical trials
    George F Longstreth
    Department of Gastroenterology, Kaiser Permanente Medical Center, San Diego, California, USA
    Eur J Gastroenterol Hepatol 17:411-20. 2005
    ..To develop a disease-specific questionnaire to capture the impact of irritable bowel syndrome (IBS) and its treatment on patients' lives, the Irritable Bowel Syndrome Impact Scale (IBS-IS)...
  70. ncbi request reprint Enhanced preattentive central nervous system reactivity in irritable bowel syndrome
    Steven M Berman
    CURE Digestive Diseases Research Center, Department of Medicine, University of California, Los Angeles 90073, USA
    Am J Gastroenterol 97:2791-7. 2002
    ..We hypothesize that the increased responsiveness of IBS patients is a generalized phenomenon applying to stimuli other than visceral and attempt to demonstrate increased responsiveness to sounds as measured by the P1 scalp potential...
  71. ncbi request reprint Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia
    Sylvie Bradesi
    Department of Medicine, Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at University of California, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California 90073, USA
    Am J Physiol Gastrointest Liver Physiol 289:G42-53. 2005
    ....
  72. ncbi request reprint Brain responses to visceral and somatic stimuli in patients with irritable bowel syndrome with and without fibromyalgia
    Lin Chang
    C N S Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Am J Gastroenterol 98:1354-61. 2003
    ....
  73. ncbi request reprint AGA technical review on irritable bowel syndrome
    Douglas A Drossman
    UNC Center for Functional GI and Motility Disorders, Division of Digestive Diseases, University of North Carolina, Chapel Hill, USA
    Gastroenterology 123:2108-31. 2002
  74. ncbi request reprint Dissecting the components of the central response to stress
    Emeran A Mayer
    Nat Neurosci 6:1011-2. 2003
  75. doi request reprint The challenge of studying the biology of complex, symptom-based GI disorders
    Emeran A Mayer
    Gastroenterology 134:1826-7. 2008
  76. ncbi request reprint Is lansoprazole effective for the initial management of young patients with dyspepsia?
    Emeran A Mayer
    David Geffen School of Medicine, Suite 700, 100 UCLA Medical Plaza, Los Angeles, CA 90095, USA
    Nat Clin Pract Gastroenterol Hepatol 5:200-1. 2008
  77. ncbi request reprint Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia
    Silvia Amadesi
    Department of Surgery, University of California, San Francisco, California 94143 0660, USA
    J Neurosci 24:4300-12. 2004
    ..We have identified a novel mechanism by which proteases that activate PAR2 sensitize TRPV1 through PKC. Antagonism of PAR2, TRPV1, or PKC may abrogate protease-induced thermal hyperalgesia...
  78. ncbi request reprint Primary endpoints for irritable bowel syndrome trials: a review of performance of endpoints
    Michael Camilleri
    CENTER Program, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Clin Gastroenterol Hepatol 5:534-40. 2007
    ....
  79. ncbi request reprint Brain imaging in IBS: drawing the line between cognitive and non-cognitive processes
    Bruce D Naliboff
    Gastroenterology 130:267-70. 2006
  80. ncbi request reprint Functional abdominal pain syndrome
    Ray E Clouse
    Division of Gastroenterology, Washington University, St Louis, Missouri 63110, USA
    Gastroenterology 130:1492-7. 2006
    ..Psychological treatment options include psychotherapy, relaxation techniques, and hypnosis. Refractory FAPS patients may benefit from a multidisciplinary pain clinic approach...
  81. pmc Novel therapeutic approaches in IBS
    Sylvie Bradesi
    UCLA Center for Neurovisceral Sciences and Women s Health, and Departments of Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles, CA 90024, USA
    Curr Opin Pharmacol 7:598-604. 2007
    ..Recent new evidence for a possible role of altered microflora and altered host microbial interactions may provide new treatment targets in the future...

Research Grants24

  1. PERCEPTION AND MODULATION OF VISCERAL SENSATIONS
    Emeran Mayer; Fiscal Year: 2005
    ....
  2. Peripheral NMDA receptors in visceral nociception
    Emeran Mayer; Fiscal Year: 2005
    ..Aim 3 will identify the role of NMDAR in distension mediated EPAN activity in vivo and ex vivo. ..
  3. Peripheral NMDA receptors in visceral nociception
    Emeran Mayer; Fiscal Year: 2006
    ..These studies are likely to contribute significantly to our understanding of the mechanisms underlying enhanced visceral pain associated with functional and inflammatory disorders of the Gl tract. ..
  4. Mind/Brain/Body Interactions in Stress-Related Disorders
    Emeran Mayer; Fiscal Year: 2007
    ....
  5. Center for Neurovisceral Sciences & Women's Health
    Emeran Mayer; Fiscal Year: 2007
    ..Thus, the synergy expected from the Center promises to have a large impact upon expanded research into a highly prevalent, but inadequately treated area of women's health. ..
  6. PERCEPTION AND MODULATION OF VISCERAL SENSATIONS
    Emeran Mayer; Fiscal Year: 2007
    ..A better understanding of brain circuits which underlie predominant symptoms, and associated genetic traits will greatly facilitate the development of better treatments for these common Gl disorders. ..
  7. Center for Neurovisceral Sciences & Women's Health
    Emeran Mayer; Fiscal Year: 2007
    ..List all other key personnelin alphabeticalorder,last namefirst. Name Organization Role on Project Emeran Mayer, MD University of California, LA, Dept. of Medicine Center P,I. and Project(I) P.I...
  8. Perception and Modulation of Visceral Sensation
    Emeran Mayer; Fiscal Year: 2009
    ....
  9. Peripheral NMDA receptors in visceral nociception
    Emeran Mayer; Fiscal Year: 2004
    ..Aim 3 will identify the role of NMDAR in distension mediated EPAN activity in vivo and ex vivo. ..
  10. PERCEPTION AND MODULATION OF VISCERAL SENSATIONS
    Emeran Mayer; Fiscal Year: 2004
    ....
  11. PERCEPTION AND MODULATION OF VISCERAL SENSATIONS
    Emeran Mayer; Fiscal Year: 1999
    ..Once such alterations are identified, they may provide reliable physiological markers and therapeutic targets in the future. ..
  12. Peripheral NMDA receptors in visceral nociception
    Emeran Mayer; Fiscal Year: 2001
    ..Aim 3 will identify the role of NMDAR in distension mediated EPAN activity in vivo and ex vivo. ..
  13. PERCEPTION AND MODULATION OF VISCERAL SENSATIONS
    Emeran Mayer; Fiscal Year: 2001
    ....
  14. PERCEPTION AND MODULATION OF VISCERAL SENSATIONS
    Emeran Mayer; Fiscal Year: 2002
    ....
  15. Peripheral NMDA receptors in visceral nociception
    Emeran Mayer; Fiscal Year: 2002
    ..Aim 3 will identify the role of NMDAR in distension mediated EPAN activity in vivo and ex vivo. ..
  16. PERCEPTION AND MODULATION OF VISCERAL SENSATIONS
    Emeran Mayer; Fiscal Year: 2003
    ....
  17. Peripheral NMDA receptors in visceral nociception
    Emeran Mayer; Fiscal Year: 2003
    ..Aim 3 will identify the role of NMDAR in distension mediated EPAN activity in vivo and ex vivo. ..
  18. Peripheral NMDA receptors in visceral nociception
    Emeran Mayer; Fiscal Year: 2003
    ..Aim 3 will identify the role of NMDAR in distension mediated EPAN activity in vivo and ex vivo. ..
  19. Perception and Modulation of Visceral Sensation
    Emeran A Mayer; Fiscal Year: 2010
    ....