Research Topics
| Emeran MayerSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
An update on the use and investigation of probiotics in health and diseaseMary Ellen Sanders
Oppenheimer Center for Neurobiology of Stress, Division of Digestive Diseases, UCLA CHS 47 122, 10833 Le Conte Ave, Los Angeles, CA 90095 7378, USA
Gut 62:787-96. 2013....- Gut feelings: the emerging biology of gut-brain communicationEmeran A Mayer
Center for Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, CHS 47 122 10833 Le Conte Avenue, Los Angeles, California 90095 7378, USA
Nat Rev Neurosci 12:453-66. 2011..Moreover, disturbances of this system have been implicated in a wide range of disorders, including functional and inflammatory gastrointestinal disorders, obesity and eating disorders... 
Inflammation in irritable bowel syndrome: curiosity or culpritEmeran A Mayer
Center of Neurovisceral Sciences and Women's Health, David Geffen School of Medicine at UCLA, Building 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
J Pediatr Gastroenterol Nutr 39:S751-3. 2004- Sex-based differences in gastrointestinal painEmeran A Mayer
Departments of Medicine, Psychiatry and Biobehavioral Sciences, CNS Center for Neurovisceral Sciences and Women s Health, UCLA Division of Digestive Diseases, UCLA and VA GLAHS, WLA VA Medical Center, Los Angeles, CA 90073, USA
Eur J Pain 8:451-63. 2004..Consistent with experimental findings in animals, current evidence is consistent with a pathophysiological model which emphasizes sex-related differences in autonomic and antinociceptive responses to certain visceral stimuli... - Differences in brain responses to visceral pain between patients with irritable bowel syndrome and ulcerative colitisEmeran A Mayer
Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine, University of California, Los Angeles, CA 90073, USA
Pain 115:398-409. 2005.... - Clinical practice. Irritable bowel syndromeEmeran A Mayer
Center for Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-6949, USA
N Engl J Med 358:1692-9. 2008 - Commentary on peripheral and central contributions to hyperalgesia in irritable bowel syndromeEmeran A Mayer
Center for Neurovisceral Sciences and Women's Health, Department of Medicine, Physiology, and Psychiatry, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
J Pain 7:539-41; discussion 542-3. 2006 - Review article: modulation of the brain-gut axis as a therapeutic approach in gastrointestinal diseaseE A Mayer
Department of Medicine, Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
Aliment Pharmacol Ther 24:919-33. 2006..Numerous current and emerging therapies aimed at normalizing brain-gut interactions are a focus of interest, particularly for irritable bowel syndrome and functional dyspepsia... - Neuroimaging of the brain-gut axis: from basic understanding to treatment of functional GI disordersEmeran A Mayer
Center for Neurovisceral Sciences and Women's Health, David Geffen School of Medicine at UCLA, Los Angeles, California 90073, USA
Gastroenterology 131:1925-42. 2006 - Functional GI disorders: from animal models to drug developmentE A Mayer
UCLA Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
Gut 57:384-404. 2008.... - Brain imaging approaches to the study of functional GI disorders: a Rome working team reportE A Mayer
Center for Neurobiology of Stress, Department of Medicine, Division of Digestive Diseases, David Geffen School of Medicine, UCLA, Los Angeles, CA 90073, USA
Neurogastroenterol Motil 21:579-96. 2009..The article concludes with a critical assessment of published studies, and with recommendations for improved study paradigms and analysis strategies... - The brain-gut axis in abdominal pain syndromesEmeran A Mayer
Center for Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
Annu Rev Med 62:381-96. 2011.... - Alosetron and irritable bowel syndromeEmeran A Mayer
Center for Neurovisceral Sciences and Women s Health, VAGLAHS, Bldg 115 CURE 11301 Wilshire Blvd, Los Angeles, CA 90073, USA
Expert Opin Pharmacother 4:2089-98. 2003..The impact of alosetron on QOL in IBS patients and the safety of treatment with alosetron, will also be covered... - V. Stress and irritable bowel syndromeE A Mayer
UCLA CURE Neuroenteric Disease Program, Departments of Medicine, Physiology, and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California 90024, USA
Am J Physiol Gastrointest Liver Physiol 280:G519-24. 2001..Functional brain imaging techniques are beginning to identify brain circuits involved in the perceptual alterations. Animal models have recently been proposed that mimic key features of the human syndrome... - Evolving pathophysiologic models of functional gastrointestinal disordersEmeran A Mayer
CURE Neuroenteric Disease Program, UCLA Division of Digestive Diseases and Brain Research Institute, Los Angeles, California 90073, USA
Gastroenterology 122:2032-48. 2002..Future development of existing and novel models involves the use of transgenic and knockout animals, as well as the demonstration of predictive validity in terms of responsiveness to candidate drugs... - The evolving neurobiology of gut feelingsE A Mayer
Department of Medicine and Physiology, UCLA School of Medicine 90024, USA
Prog Brain Res 122:195-206. 2000..Alterations in this bi-directional process such as peripheral pathologies within the gut or alterations at the brain level may explain the close association between certain affective disorders and functional visceral syndromes... - The effect of the 5-HT3 receptor antagonist, alosetron, on brain responses to visceral stimulation in irritable bowel syndrome patientsE A Mayer
CURE Digestive Diseases Research Center Neuroenteric Disease Program, Department of Medicine, University of California School of Medicine, Los Angeles, CA 90073, USA
Aliment Pharmacol Ther 16:1357-66. 2002.... - Depression, anxiety, and the gastrointestinal systemE A Mayer
Department of Medicine, University of California, Los Angeles, USA
J Clin Psychiatry 62:28-36; discussion 37. 2001.... - Basic pathophysiologic mechanisms in irritable bowel syndromeE A Mayer
UCLA CURE Neuroenteric Disease Program, Department of Medicine, Physiology and Biobehavioral Sciences, UCLA School of Medicine, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Dig Dis 19:212-8. 2001..IBS patients show an enhanced responsiveness of this system manifesting in altered modulation of gastrointestinal motility, secretion, immune function and in alterations in the perceptual and emotional response to visceral events... - Current insights into the pathophysiology of irritable bowel syndromeInes Schwetz
Center of Neurovisceral Sciences and Women s Health, CURE Digestive Diseases Research Center, David Geffen School of Medicine at UCLA, VAGLAHS, Bldg 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Curr Gastroenterol Rep 5:331-6. 2003.... - Review article: gender-related differences in functional gastrointestinal disordersE A Mayer
CURE Neuroenteric Disease Program, UCLA Division of Digestive Diseases, USA
Aliment Pharmacol Ther 13:65-9. 1999.... - Approaches to the modulation of abdominal painE A Mayer
UCLA CURE Neuroenteric Disease Program, Department of Medicine, Physiology and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90073, USA
Can J Gastroenterol 13:65A-70A. 1999.... - Emerging drugs for irritable bowel syndromeSylvie Bradesi
Center for Neurovisceral Sciences and Women's Health, CURE: Digestive Diseases Research Center, UCLA Division of Digestive Diseases, GLA VA HC Bldg, 115/CURE, 11301 Wilshire Blvd, Los Angeles, California 90073, USA
Expert Opin Emerg Drugs 11:293-313. 2006..Advances in clinical trial design will help to evaluate these compounds in different IBS patient populations... - Proximal colon distention increases Fos expression in the lumbosacral spinal cord and activates sacral parasympathetic NADPHd-positive neurons in ratsV Martinez
Department of Medicine, CURE Digestive Diseases Research Center, West Los Angeles VA Medical Center, California 90073, USA
J Comp Neurol 390:311-21. 1998..The marked activation of NADPHd-positive neurons in the sacral parasympathetic nucleus suggests a possible role of nitric oxide in the visceroautonomic reflexes induced by distention of the proximal colon... 
Measuring irritable bowel syndrome patient-reported outcomes with an abdominal pain numeric rating scaleB Spiegel
VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Aliment Pharmacol Ther 30:1159-70. 2009..Pain numeric rating scales (NRS) are widely used in the non-IBS pain literature. The Food and Drug Administration has proposed using the NRS in IBS...- Developing valid and reliable health utilities in irritable bowel syndrome: results from the IBS PROOF CohortBrennan Spiegel
VA Greater Los Angeles Healthcare System UCLA, Digestive Diseaes, 11301 Wilshire Blvd, Building 11, Room 21E, Los Angeles, California 90073, USA
Am J Gastroenterol 104:1984-91. 2009..To inform future cost-utility analyses in IBS, we measured and validated the IBS utilities... - The impact of somatization on the use of gastrointestinal health-care resources in patients with irritable bowel syndromeBrennan M R Spiegel
Division of Gastroenterology, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Am J Gastroenterol 100:2262-73. 2005..This suggests that somatization is positively associated with health-care costs in IBS, and that the association may be driven more by physicians than patients... - Sex differences in regional brain response to aversive pelvic visceral stimuliSteven M Berman
University of California, Los Angeles UCLA, Center for Neurovisceral Sciences and Women s Health, Department of Medicine, and Veterans Affairs Greater Los Angeles Healthcare System, CA 90073, USA
Am J Physiol Regul Integr Comp Physiol 291:R268-76. 2006..Greater familiarity of females with physiological pelvic visceral discomfort may have enhanced brain systems that dampen arousal networks during lower levels of discomfort... - Longitudinal change in perceptual and brain activation response to visceral stimuli in irritable bowel syndrome patientsBruce D Naliboff
Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Gastroenterology 131:352-65. 2006..Repeated stimulus exposure leads to decreased salience of threat and reduction of hypervigilance. We sought to evaluate hypervigilance in IBS visceral hypersensitivity and associated brain activity... - Two N-methyl-D-aspartate receptors in rat dorsal root ganglia with different subunit composition and localizationJuan Carlos G Marvizon
Neuroenteric Disease Program, CURE Digestive Diseases Research Center, Department of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
J Comp Neurol 446:325-41. 2002.... - Dual role of 5-HT3 receptors in a rat model of delayed stress-induced visceral hyperalgesiaSylvie Bradesi
Center for Neurovisceral Sciences and Women s Health, Department of Medicine, VAGLAHS CURE Building 115, Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Pain 130:56-65. 2007..In addition, we showed that stress-induced sensitization of visceral nociception is independent of 5-HT3R activation on vagal afferents... - The role of neurokinin 1 receptors in the maintenance of visceral hyperalgesia induced by repeated stress in ratsSylvie Bradesi
Center for Neurovisceral Sciences and Women's Health, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
Gastroenterology 130:1729-42. 2006.... - The central role of gastrointestinal-specific anxiety in irritable bowel syndrome: further validation of the visceral sensitivity indexJennifer S Labus
Department of Psychiatry and Biobehavioral Sciences, Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Psychosom Med 69:89-98. 2007.... - Predictors of patient-assessed illness severity in irritable bowel syndromeBrennan Spiegel
VA Greater Los Angeles Healthcare System, Center for Outcomes Research and Education, Los Angeles, California, USA
Am J Gastroenterol 103:2536-43. 2008..Since severity is a patient-centered outcome, it is essential that future instruments are based on patients' self-perceptions of severity. We measured patient-derived predictors of severity in a large cohort of IBS patients... - Corticotropin-releasing factor receptor 1 mediates acute and delayed stress-induced visceral hyperalgesia in maternally separated Long-Evans ratsInes Schwetz
Center for Neurovisceral Sciences and Women's Health, University of California Los Angeles, CA 90073, USA
Am J Physiol Gastrointest Liver Physiol 289:G704-12. 2005..Both acute and delayed stress-induced visceral hypersensitivity in MS rats are mediated by the CRF/CRF(1)R system... - Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in ratsMuriel Larauche
Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA 90095, USA
Am J Physiol Gastrointest Liver Physiol 294:G1033-40. 2008..These data support a major role for CRF(1) in both the development and maintenance of visceral hyperalgesia induced by repeated stress and indicate a possible role of peripheral CRF receptors in such mechanisms... - Effect of abuse history on pain reports and brain responses to aversive visceral stimulation: an FMRI studyYehuda Ringel
UNC Center for Functional GI and Motility Disorders, University of North Carolina, Chapel Hill, North Carolina, USA
Gastroenterology 134:396-404. 2008..These effects may be mediated by enhanced responses to aversive visceral stimuli. We investigated the effects of IBS and abuse history on pain reporting and brain activation in response to rectal distentions... - The effect of auditory stress on perception of intraesophageal acid in patients with gastroesophageal reflux diseaseRonnie Fass
The Neuro Enteric Clinical Research Group, Section of Gastroenterology, Department of Medicine, Southern Arizona VA Health Care System and Arizona Health Sciences Center, Tucson, Arizona, USA
Gastroenterology 134:696-705. 2008..We sought to determine the effect of an acute laboratory stressor on perceptual and emotional responses to intraesophageal acid perfusion in healthy controls and patients with GERD... - Reduced brainstem inhibition during anticipated pelvic visceral pain correlates with enhanced brain response to the visceral stimulus in women with irritable bowel syndromeSteven M Berman
Department of Medicine, University of California, Los Angeles Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine at University of California, Los Angeles, 90073, USA
J Neurosci 28:349-59. 2008.... - Studying sex and gender differences in pain and analgesia: a consensus reportJoel D Greenspan
Department of Biomedical Sciences, University of Maryland Dental School, University of Maryland, Baltimore, MD 21201 1510, USA
Pain 132:S26-45. 2007..and thought-provoking guide for future research on sex and gender differences in pain and analgesia, both for those currently working in this field as well as those still wondering, "Do I really need to study females?".. - Psychometric properties of the Early Trauma Inventory-Self ReportJ Douglas Bremner
Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia 30306, USA
J Nerv Ment Dis 195:211-8. 2007..These findings suggest that the ETI-SR is a valid measure of early trauma, and suggest future directions for a shortened version of the ETI-SR that could be more easily incorporated into clinical research studies and practice settings... - Enteric neuroscience: the dawn of a new disciplineEmeran A Mayer
Gastroenterology 132:1217-8. 2007 - Effect of sex on perception of rectosigmoid stimuli in irritable bowel syndromeLin Chang
Center for Neurovisceral Sciences and Women s Health, Department of Medicine, David Geffen School of Medicine at University of California, Los Angeles, and Veterans Affairs Greater Los Angeles Healthcare System, California 90073, USA
Am J Physiol Regul Integr Comp Physiol 291:R277-84. 2006..01), while men did not. Sex significantly influences perceptual sensitivity to rectosigmoid distension. Women show greater perceptual responses to this paradigm... - Experimental colitis modulates the functional properties of NMDA receptors in dorsal root ganglia neuronsJichang Li
Department of Medicine, Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
Am J Physiol Gastrointest Liver Physiol 291:G219-28. 2006..In conclusion, colonic inflammation upregulates the activity of NMDARs in all DRG neurons within ganglia innervating this tissue through mechanisms involving increased expression and persistent tyrosine phosphorylation... - Electrophysiological characterization of N-methyl-D-aspartate receptors in rat dorsal root ganglia neuronsJichang Li
Division of Digestive Diseases, Department of Medicine, Center for Neurovisceral Sciences (CNS) and Women's Health, University of California, Warren Hall, Room 14-103, 900 Veterans Avenue, Los Angeles, CA 90095, USA
Pain 109:443-52. 2004..These results demonstrate that functional NMDARs expressed by DRG neurons innervating both somatic and visceral tissues of adult rats are composed predominantly of NR2B subunits... - Effect of transient chemically induced colitis on the visceromotor response to mechanical colorectal distensionJürgen M Gschossmann
Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of Essen, Hufelandstrasse 55, 45122 Essen, Germany
Eur J Gastroenterol Hepatol 14:1067-72. 2002..Acute mucosal inflammation may initiate alterations of visceral sensory function. However, experimental studies on the potential effects of a transient inflammation on visceral sensitivity are lacking... - Sex-related differences in IBS patients: central processing of visceral stimuliBruce D Naliboff
Center for Neurovisceral Sciences and Women s Health, UCLA School of Medicine, CURE Building, 115 Room 223, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
Gastroenterology 124:1738-47. 2003..The aim of this study was to determine possible sex-related differences in brain responses to a visceral and a psychological stressor in IBS... - Brain responses to visceral and somatic stimuli in patients with irritable bowel syndrome with and without fibromyalgiaLin Chang
C.N.S. Center for Neurovisceral Sciences and Women's Health, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
Am J Gastroenterol 98:1354-61. 2003.... - A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in ratsMulugeta Million
CURE Digestive Diseases Research Center and Center for Neurovisceral Sciences and Women s Health CNS, West Los Angeles VA Medical Center, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90073, USA
Brain Res 985:32-42. 2003.... - The neural correlates of placebo effects: a disruption accountMatthew D Lieberman
Department of Psychology, University of California Los Angeles, Franz Hall, 405 Hilgard Avenue, Los Angeles, CA 90095 1563, USA
Neuroimage 22:447-55. 2004..This is the first study to identify a neural pathway from a region of the brain associated with placebos and affective thought to a region closely linked to the placebo-related outcome of diminished pain unpleasantness... - Collaborative health for IBSEmeran A Mayer
Clin Gastroenterol Hepatol 1:423-4. 2003 - Prevalence of irritable bowel syndrome among university students: the roles of worry, neuroticism, anxiety sensitivity and visceral anxietyHolly Hazlett-Stevens
Department of Psychology 298, University of Nevada, Reno, NV 89557, USA
J Psychosom Res 55:501-5. 2003..Relationships between presence of irritable bowel syndrome (IBS) and generalized anxiety disorder (GAD), chronic worry, neuroticism, anxiety sensitivity and anxiety about visceral sensations were examined among university students... - Regional brain activation in conscious, nonrestrained rats in response to noxious visceral stimulationZhuo Wang
Center for the Neurobiology of Stress, Brain Research Institute, UCLA, Los Angeles, CA, USA
Pain 138:233-43. 2008..This suggests that functional brain imaging captures more extensive responses of the central nervous system to noxious visceral distension than those identified by traditional measures... - Delayed stress-induced colonic hypersensitivity in male Wistar rats: role of neurokinin-1 and corticotropin-releasing factor-1 receptorsInes Schwetz
Center for Neurovisceral Sciences and Women's Health, Department of Medicine, David Gaffen School of Medicine ar University of California, Los Angeles 90024, USA
Am J Physiol Gastrointest Liver Physiol 286:G683-91. 2004..Chemical sympathectomy did not affect delayed SICH. Our results indicate that in male Wistar rats, both NK(1)R and CRF(1)R activation, but not sympathetic nervous system activation, play a role in the development of SICH... - Enhanced preattentive central nervous system reactivity in irritable bowel syndromeSteven M Berman
CURE Digestive Diseases Research Center, Department of Medicine, University of California, Los Angeles 90073, USA
Am J Gastroenterol 97:2791-7. 2002..A generalized preattentive increase in central nervous system reactivity may be a feature that IBS shares with several anxiety disorders that frequently co-occur in these patients... - Irritable bowel syndrome patients show enhanced modulation of visceral perception by auditory stressBritta Dickhaus
University of California, Department of Medicine, Los Angeles (UCLA)/CNS: Center for Neurovisceral Sciences and Women's Health, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA
Am J Gastroenterol 98:135-43. 2003..CONCLUSION: These findings confirm the hypothesis of altered stress-induced modulation of visceral perception in IBS patients... - The effect of life stress on symptoms of heartburnBruce D Naliboff
Center for Neurovisceral Sciences and Women s Health, Department of Medicine, UCLA, Los Angeles, CA, USA
Psychosom Med 66:426-34. 2004..The present longitudinal study tests the general hypothesis that life stressors can exacerbate symptoms in patients with chronic heartburn... - Is a negative colonoscopy associated with reassurance or improved health-related quality of life in irritable bowel syndrome?Brennan M R Spiegel
Division of Gastroenterology, VA Greater Los Angeles Healthcare System, CA 90073, USA
Gastrointest Endosc 62:892-9. 2005..However, no previous data have measured these effects. We sought to measure the association of a normal colonoscopy with reassurance and HRQOL in patients with IBS aged <50 years... - Pain perception in irritable bowel syndromeKirsten Tillisch
Center for Neurovisceral Sciences and Women s Health, David Geffen School of Medicine, University of California Los Angeles, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
CNS Spectr 10:877-82. 2005..The frequent comorbidity with psychiatric disorders suggests the possibility of shared pathophysiological mechanisms and etiologic factors... - Is there a difference between abdominal pain and discomfort in moderate to severe IBS patients?Joel Sach
C N S Center for Neurovisceral Sciences and Women s Health, Los Angeles, California, USA
Am J Gastroenterol 97:3131-8. 2002.... - Characterization of the alternating bowel habit subtype in patients with irritable bowel syndromeKirsten Tillisch
CNS/WH: Center for Neurovisceral Sciences and Women's Health, Department of Medicine, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles, California, USA
Am J Gastroenterol 100:896-904. 2005..CONCLUSIONS: IBS-A patients have rapidly fluctuating symptoms and increased psychological comorbidity, which should be taken into account for clinical practice and clinical trials... - Impact of irritable bowel syndrome on patients' lives: development and psychometric documentation of a disease-specific measure for use in clinical trialsGeorge F Longstreth
Department of Gastroenterology, Kaiser Permanente Medical Center, San Diego, California, USA
Eur J Gastroenterol Hepatol 17:411-20. 2005..To develop a disease-specific questionnaire to capture the impact of irritable bowel syndrome (IBS) and its treatment on patients' lives, the Irritable Bowel Syndrome Impact Scale (IBS-IS)... - Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesiaSylvie Bradesi
Department of Medicine, Center for Neurovisceral Sciences and Women's Health, David Geffen School of Medicine at University of California, Greater Los Angeles Veterans Affairs Healthcare System, Los Angeles, California 90073, USA
Am J Physiol Gastrointest Liver Physiol 289:G42-53. 2005.... - A dose-ranging, phase II study of the efficacy and safety of alosetron in men with diarrhea-predominant IBSLin Chang
Center for Neurovisceral Sciences and Women's Health, UCLA Division of Digestive Diseases, Los Angeles, California, USA
Am J Gastroenterol 100:115-23. 2005..CONCLUSIONS: Alosetron 1 mg twice daily provided adequate relief of IBS pain and discomfort, and improved stool consistency in men with diarrhea-predominant IBS... - Racial differences in the impact of irritable bowel syndrome on health-related quality of lifeIan M Gralnek
VA Greater Los Angeles Health Care System, Los Angeles, CA, USA
J Clin Gastroenterol 38:782-9. 2004..To compare the impact of irritable bowel syndrome (IBS) on health related quality of life (HRQOI) for non-white and white IBS patients... - Clinical determinants of health-related quality of life in patients with irritable bowel syndromeBrennan M R Spiegel
Division of Gastroenterology, the VA Greater Los Angeles Healthcare System, CA 90073, USA
Arch Intern Med 164:1773-80. 2004..The identification of predictive factors could allow physicians to better assess HRQOL without using misleading clinical clues. We, therefore, sought to identify determinants of HRQOL in patients with IBS... - Condition-specific deactivation of brain regions by 5-HT3 receptor antagonist AlosetronSteven M Berman
CURE/Neuroenteric Disease Program, Department of Medicine, University of California School of Medicine, Los Angeles, California 90073, USA
Gastroenterology 123:969-77. 2002..CONCLUSIONS: Reduction in IBS symptoms correlated with a drug-induced reduction in the activity of central autonomic networks mediating emotional expression that was maximal in the absence of nociceptive input... - Dissecting the components of the central response to stressEmeran A Mayer
Nat Neurosci 6:1011-2. 2003 - The challenge of studying the biology of complex, symptom-based GI disordersEmeran A Mayer
Gastroenterology 134:1826-7. 2008 - Is lansoprazole effective for the initial management of young patients with dyspepsia?Emeran A Mayer
David Geffen School of Medicine, Suite 700, 100 UCLA Medical Plaza, Los Angeles, CA 90095, USA
Nat Clin Pract Gastroenterol Hepatol 5:200-1. 2008 - Novel therapeutic approaches in IBSSylvie Bradesi
UCLA Center for Neurovisceral Sciences and Women s Health, and Departments of Medicine, David Geffen School of Medicine at UCLA, University of California Los Angeles, CA 90024, USA
Curr Opin Pharmacol 7:598-604. 2007..Recent new evidence for a possible role of altered microflora and altered host microbial interactions may provide new treatment targets in the future... - Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesiaSilvia Amadesi
Department of Surgery, University of California, San Francisco, California 94143 0660, USA
J Neurosci 24:4300-12. 2004..We have identified a novel mechanism by which proteases that activate PAR2 sensitize TRPV1 through PKC. Antagonism of PAR2, TRPV1, or PKC may abrogate protease-induced thermal hyperalgesia... - AGA technical review on irritable bowel syndromeDouglas A Drossman
UNC Center for Functional GI and Motility Disorders, Division of Digestive Diseases, University of North Carolina, Chapel Hill, USA
Gastroenterology 123:2108-31. 2002 - Primary endpoints for irritable bowel syndrome trials: a review of performance of endpointsMichael Camilleri
CENTER Program, Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
Clin Gastroenterol Hepatol 5:534-40. 2007.... - Functional abdominal pain syndromeRay E Clouse
Division of Gastroenterology, Washington University, St Louis, Missouri 63110, USA
Gastroenterology 130:1492-7. 2006..Psychological treatment options include psychotherapy, relaxation techniques, and hypnosis. Refractory FAPS patients may benefit from a multidisciplinary pain clinic approach... - Brain imaging in IBS: drawing the line between cognitive and non-cognitive processesBruce D Naliboff
Gastroenterology 130:267-70. 2006
Research Grants
- PERCEPTION AND MODULATION OF VISCERAL SENSATIONSEmeran Mayer; Fiscal Year: 2005....
- Peripheral NMDA receptors in visceral nociceptionEmeran Mayer; Fiscal Year: 2005..Aim 3 will identify the role of NMDAR in distension mediated EPAN activity in vivo and ex vivo. ..
- Peripheral NMDA receptors in visceral nociceptionEmeran Mayer; Fiscal Year: 2006..These studies are likely to contribute significantly to our understanding of the mechanisms underlying enhanced visceral pain associated with functional and inflammatory disorders of the Gl tract. ..
- Mind/Brain/Body Interactions in Stress-Related DisordersEmeran Mayer; Fiscal Year: 2007....
- Center for Neurovisceral Sciences & Women's HealthEmeran Mayer; Fiscal Year: 2007..Thus, the synergy expected from the Center promises to have a large impact upon expanded research into a highly prevalent, but inadequately treated area of women's health. ..
- PERCEPTION AND MODULATION OF VISCERAL SENSATIONSEmeran Mayer; Fiscal Year: 2007..A better understanding of brain circuits which underlie predominant symptoms, and associated genetic traits will greatly facilitate the development of better treatments for these common Gl disorders. ..
- Center for Neurovisceral Sciences & Women's HealthEmeran Mayer; Fiscal Year: 2007..List all other key personnelin alphabeticalorder,last namefirst. Name Organization Role on Project Emeran Mayer, MD University of California, LA, Dept. of Medicine Center P,I. and Project(I) P.I...
- PERCEPTION AND MODULATION OF VISCERAL SENSATIONSEmeran Mayer; Fiscal Year: 1999..Once such alterations are identified, they may provide reliable physiological markers and therapeutic targets in the future. ..
- Perception and Modulation of Visceral SensationEmeran A Mayer; Fiscal Year: 2010....