Affiliation: University of Vermont
Liao C, May V, Li J. PAC1 Receptors: Shapeshifters in Motion. J Mol Neurosci. 2018;: pubmed publisher
..The PAC1R shapeshifts also have the ability of delineating the mechanisms and the design of reagents that may direct biased agonism (or antagonism) for potential therapeutics. ..
Missig G, Mei L, Vizzard M, Braas K, Waschek J, Ressler K, et al
. Parabrachial Pituitary Adenylate Cyclase-Activating Polypeptide Activation of Amygdala Endosomal Extracellular Signal-Regulated Kinase Signaling Regulates the Emotional Component of Pain. Biol Psychiatry. 2017;81:671-682 pubmed publisher
..Thus, the PACAP pathway provides for an important mechanism underlying the intersection of stress and chronic pain pathways via the amygdala. ..
May V, Lutz E, MacKenzie C, Schutz K, Dozark K, Braas K. Pituitary adenylate cyclase-activating polypeptide (PACAP)/PAC1HOP1 receptor activation coordinates multiple neurotrophic signaling pathways: Akt activation through phosphatidylinositol 3-kinase gamma and vesicle endocytosis for neuronal survival. J Biol Chem. 2010;285:9749-61 pubmed publisher
..The partitioning of PACAP-mediated Akt signaling in endosomes may be a key mechanism contributing to the high spatial and temporal specificity in signal transduction necessary for survival pathways. ..
Missig G, Roman C, Vizzard M, Braas K, Hammack S, May V. Parabrachial nucleus (PBn) pituitary adenylate cyclase activating polypeptide (PACAP) signaling in the amygdala: implication for the sensory and behavioral effects of pain. Neuropharmacology. 2014;86:38-48 pubmed publisher