Mitchell B Max

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?
    Mark Lazarev
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Pain 4:58. 2008
  2. doi request reprint The molecular epidemiology of pain: a new discipline for drug discovery
    Mitchell B Max
    Center for Pain Research, Departments of Anesthesiology and Medicine, University of Pittsburgh, A 1305 Scaife Hall, 3550 Terrace St, Pittsburgh, Pennsylvania 15261, USA
    Nat Rev Drug Discov 7:647-58. 2008
  3. pmc Do motor control genes contribute to interindividual variability in decreased movement in patients with pain?
    Bikash K Mishra
    Clinical Pain Research Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD, USA
    Mol Pain 3:20. 2007
  4. ncbi request reprint Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms
    Jorn Lotsch
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Clin Chem 53:1010-5. 2007
  5. ncbi request reprint Developing patient-reported outcome measures for pain clinical trials: IMMPACT recommendations
    Dennis C Turk
    University of Washington, Seattle, WA 98195, USA
    Pain 125:208-15. 2006
  6. ncbi request reprint GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
    Irmgard Tegeder
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Room 4309, Charlestown, Massachusetts 02129, USA
    Nat Med 12:1269-77. 2006
  7. ncbi request reprint Effects of chronic osteoarthritis pain on neuroendocrine function in men
    Suzan Khoromi
    Laboratory of Clinical Investigation, Division of Intramural Research, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892 1302, USA
    J Clin Endocrinol Metab 91:4313-8. 2006
  8. ncbi request reprint Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli
    Luda Diatchenko
    Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, NC, USA
    Pain 125:216-24. 2006
  9. ncbi request reprint Use of the cumulative proportion of responders analysis graph to present pain data over a range of cut-off points: making clinical trial data more understandable
    John T Farrar
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Pain Symptom Manage 31:369-77. 2006
  10. pmc A clinical genetic method to identify mechanisms by which pain causes depression and anxiety
    Mitchell B Max
    Clinical Pain Research Section, Division of Intramural Research, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD, USA
    Mol Pain 2:14. 2006

Collaborators

  • Walter F Stewart
  • S J Atlas
  • R D Kerns
  • M S Wallace
  • DENNIS TURK
  • James P Robinson
  • R H Dworkin
  • R B Fillingim
  • M P Jensen
  • Robert R Edwards
  • I Gilron
  • Clifford J Woolf
  • Inna Belfer
  • David Goldman
  • Luda Diatchenko
  • Bikash K Mishra
  • Jorn Lotsch
  • Irmgard Tegeder
  • William Maixner
  • Tianxia Wu
  • Mark Lazarev
  • Michael Costigan
  • Gerd Geisslinger
  • Suzan Khoromi
  • John T Farrar
  • Gary D Slade
  • Andrea G Nackley
  • Albert Kingman
  • Beata Buzas
  • Christine N Sang
  • Feng Dai
  • Janette Lamb
  • M Michael Barmada
  • David C Whitcomb
  • Michelle A Anderson
  • Leonardo G Cohen
  • Colin A Hodgkinson
  • Carly Kiselycznyk
  • Alexandra Doehring
  • Qiaoping Yuan
  • Robert B Keller
  • Anja Kirchhof
  • Kanokporn Bhalang
  • Marc R Blackman
  • Helmut Schmidt
  • Barbara Moquin
  • Claudiu Marian
  • Nora Gray
  • Suvimol Hill
  • Alexander M Binshtok
  • Aram Parsegian
  • Leigh Ann Matheny
  • Laura Lee Johnson
  • Howard Baldwin
  • Kelli Anne Wong
  • Corina Ehnert
  • Ranganath Muniyappa
  • Jan Adolph
  • Andrea Abele
  • Andrew Allchorne
  • Aliya Rainer
  • Swetha Sama
  • William A Carlezon
  • Alan Remaley
  • Lisa Nackers
  • Robert S Griffin
  • Joachim Scholz
  • Jemiel Nejim
  • Asgeir Sigurdsson
  • Sergei S Makarov
  • Konakporn Bhalang
  • Dmitry Shagin
  • Svetlana A Shabalina
  • Ke Xu
  • Raj K Krishnaraju
  • Suzan Parada
  • Susan Booher

Detail Information

Publications17

  1. pmc Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?
    Mark Lazarev
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Mol Pain 4:58. 2008
    ....
  2. doi request reprint The molecular epidemiology of pain: a new discipline for drug discovery
    Mitchell B Max
    Center for Pain Research, Departments of Anesthesiology and Medicine, University of Pittsburgh, A 1305 Scaife Hall, 3550 Terrace St, Pittsburgh, Pennsylvania 15261, USA
    Nat Rev Drug Discov 7:647-58. 2008
    ..This Perspective outlines how methods of molecular epidemiology, proved effective in the study of other diseases, can enhance the returns from human genomic studies and expedite the development of new drugs to prevent or treat pain...
  3. pmc Do motor control genes contribute to interindividual variability in decreased movement in patients with pain?
    Bikash K Mishra
    Clinical Pain Research Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD, USA
    Mol Pain 3:20. 2007
    ..We demonstrate an analytic method that we applied to 14 of these genes in 290 patients with acute sciatica, whose reduction in movement was estimated by items from the Roland-Morris Disability Questionnaire...
  4. ncbi request reprint Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms
    Jorn Lotsch
    Pharmazentrum frankfurt ZAFES, Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Frankfurt am Main, Germany
    Clin Chem 53:1010-5. 2007
    ..A haplotype in the GTP cyclohydrolase 1 (dopa-responsive dystonia) gene (GCH1) is associated with decreased persistent pain. The aim of the present study was to develop a screening method for the pain-protective haplotype...
  5. ncbi request reprint Developing patient-reported outcome measures for pain clinical trials: IMMPACT recommendations
    Dennis C Turk
    University of Washington, Seattle, WA 98195, USA
    Pain 125:208-15. 2006
  6. ncbi request reprint GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence
    Irmgard Tegeder
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Room 4309, Charlestown, Massachusetts 02129, USA
    Nat Med 12:1269-77. 2006
    ..BH4 is therefore an intrinsic regulator of pain sensitivity and chronicity, and the GTP cyclohydrolase haplotype is a marker for these traits...
  7. ncbi request reprint Effects of chronic osteoarthritis pain on neuroendocrine function in men
    Suzan Khoromi
    Laboratory of Clinical Investigation, Division of Intramural Research, National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892 1302, USA
    J Clin Endocrinol Metab 91:4313-8. 2006
    ..Most endocrine studies have been conducted in patients in whom the potentially confounding effects of depression, inflammatory disease, or coexistent medication use have not been controlled...
  8. ncbi request reprint Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli
    Luda Diatchenko
    Center for Neurosensory Disorders, University of North Carolina at Chapel Hill, NC, USA
    Pain 125:216-24. 2006
    ..Here, we propose a mechanism whereby these two genetic polymorphisms differentially affect pain perception...
  9. ncbi request reprint Use of the cumulative proportion of responders analysis graph to present pain data over a range of cut-off points: making clinical trial data more understandable
    John T Farrar
    Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Pain Symptom Manage 31:369-77. 2006
    ..Whether as a primary or secondary approach to a clinical trial of pain therapy, the display of data in a CPRA format may be useful in the understanding of results and applicability to patient care...
  10. pmc A clinical genetic method to identify mechanisms by which pain causes depression and anxiety
    Mitchell B Max
    Clinical Pain Research Section, Division of Intramural Research, National Institute of Dental and Craniofacial Research, National Institutes of Health, DHHS, Bethesda, MD, USA
    Mol Pain 2:14. 2006
    ..We seek molecules that show a significant statistical interaction between (1) the amount of surgical pain relief, and (2) the alleles of the gene, on depression and anxiety during the first postoperative year...
  11. ncbi request reprint Combination pharmacotherapy for neuropathic pain: current evidence and future directions
    Ian Gilron
    Queen s University, Department of Anaesthesiology, c o Kingston General Hospital, 76 Stuart Street, Kingston, ON, K7L 2V7, Canada
    Expert Rev Neurother 5:823-30. 2005
    ..Continued close integration of basic and clinical sciences is crucial in further harnessing the potential of combination pharmacotherapy in neuropathic pain...
  12. ncbi request reprint Genetic basis for individual variations in pain perception and the development of a chronic pain condition
    Luda Diatchenko
    Comprehensive Center for Inflammatory Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Hum Mol Genet 14:135-43. 2005
    ..Thus, COMT activity substantially influences pain sensitivity, and the three major haplotypes determine COMT activity in humans that inversely correlates with pain sensitivity and the risk of developing TMD...
  13. ncbi request reprint Pain in Parkinson disease
    Beata Buzas
    Neurology 62:2156-7. 2004
  14. ncbi request reprint Candidate gene studies of human pain mechanisms: methods for optimizing choice of polymorphisms and sample size
    Inna Belfer
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    Anesthesiology 100:1562-72. 2004
  15. ncbi request reprint Assessing pain candidate gene studies
    Mitchell B Max
    Pain 109:1-3. 2004
  16. ncbi request reprint How to move pain and symptom research from the margin to the mainstream
    Mitchell B Max
    J Pain 4:355-60. 2003
    ..Academic health centers that develop the cross-disciplinary infrastructure to conduct this research will win major shares of this influx of funding and improve the diagnosis and management of many diseases...
  17. ncbi request reprint Dextromethorphan and memantine in painful diabetic neuropathy and postherpetic neuralgia: efficacy and dose-response trials
    Christine N Sang
    Pain and Neurosensory Mechanisms Branch, National Institute of Dental and Craniofacial Research, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA
    Anesthesiology 96:1053-61. 2002
    ..The authors sought to evaluate two low-affinity N-methyl-d-aspartate antagonists using a novel two-stage design...