Research Topics
| B T MausbachSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Publications
Influence of caregiver burden on the association between daily fluctuations in pleasant activities and mood: A daily diary analysisBrent T Mausbach
Department of Psychiatry, University of California, San Diego, La Jolla, 92093 0680, United States
Behav Res Ther 49:74-9. 2011..These findings suggest that screening caregivers for level of burden may help identify those most likely to benefit from behavioral interventions...
Consummatory and anticipatory anhedonia in schizophrenia: stability, and associations with emotional distress and social function over six monthsBenjamin Buck
University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Psychiatry Res 205:30-5. 2013..Implications for the measurement and conceptualization of anhedonia in schizophrenia are discussed...- The use of the theory of planned behavior to predict engagement in functional behaviors in schizophreniaBrent T Mausbach
Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0993, USA
Psychiatry Res 205:36-42. 2013..Skills training interventions that also target components of the TPB may be effective for increasing motivation to engage in learned behaviors... - A Comparison of Psychosocial Outcomes in Elderly Alzheimer Caregivers and NoncaregiversBrent T Mausbach
Department of Psychiatry, University of California, San Diego, La Jolla, California Electronic address
Am J Geriatr Psychiatry 21:5-13. 2013..To conduct an analysis of the stress, coping, and mood consequences of Alzheimer caregiving... - A longitudinal analysis of the relations among stress, depressive symptoms, leisure satisfaction, and endothelial function in caregiversBrent T Mausbach
Department of Psychiatry, University of California San Diego, La Jolla 92093 0680, USA
Health Psychol 31:433-40. 2012..This study examined the longitudinal associations between stress, depressive symptoms, leisure satisfaction, and endothelial function as measured by FMD... - Multiple mediators of the relations between caregiving stress and depressive symptomsBrent T Mausbach
Department of Psychiatry, University of California, San Diego, CA, USA
Aging Ment Health 16:27-38. 2012..e., role overload), but that this relationship would be significantly mediated by four variables: (1) personal mastery, (2) coping self-efficacy, (3) activity restriction, and (4) avoidance coping... 
Spousal caregivers of patients with Alzheimer's disease show longitudinal increases in plasma level of tissue-type plasminogen activator antigenBrent T Mausbach
Department of Psychiatry 0680, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0680, USA
Psychosom Med 69:816-22. 2007..Caring for a spouse with Alzheimer's disease has been associated with increased mortality and reduced time to developing cardiovascular disease (CVD), possibly due to impaired fibrinolysis resulting from chronic stress...- Depression and distress predict time to cardiovascular disease in dementia caregiversBrent T Mausbach
Department of Psychiatry, University of California, San Diego, CA 92093 0680, USA
Health Psychol 26:539-44. 2007..This study assessed the impact of depressive symptoms and distress from patient problem behaviors on time to developing a diagnosis of cardiovascular disease (CVD) in a sample of 643 dementia family caregivers... - Relationship of the Brief UCSD Performance-based Skills Assessment (UPSA-B) to multiple indicators of functioning in people with schizophrenia and bipolar disorderBrent T Mausbach
Department of Psychiatry, University of California at San Diego, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0680, USA
Bipolar Disord 12:45-55. 2010.... - Symptoms of psychosis and depression in middle-aged and older adults with psychotic disorders: the role of activity satisfactionBrent T Mausbach
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0680, USA
Aging Ment Health 11:339-45. 2007..Behavioral therapies which encourage engagement in reinforcing activities may provide additional benefits to existing treatments for psychosis, including reduced depression, improved well-being, and possibly functional outcomes... - Specificity of cognitive and behavioral variables to positive and negative affectBrent T Mausbach
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0680, USA
Behav Res Ther 47:608-15. 2009..If confirmed, the findings suggest the utility of focusing interventions on each of these components in the management of depressive symptoms... - Engagement in activities is associated with affective arousal in Alzheimer's caregivers: a preliminary examination of the temporal relations between activity and affectBrent T Mausbach
Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0680, USA
Behav Ther 39:366-74. 2008..Future research examining the effect of behavioral interventions on both positive and negative affect is suggested, as is the examination of factors that may be more strongly associated with negative affect... - A review of instruments for measuring functional recovery in those diagnosed with psychosisBrent T Mausbach
Schizophr Bull 35:307-18. 2009..More research on existing measures is needed, and greater funding for developing new measures of functional recovery is strongly recommended... - A 5-year longitudinal study of the relationships between stress, coping, and immune cell beta(2)-adrenergic receptor sensitivityBrent T Mausbach
Department of Psychiatry, University of California at San Diego, La Jolla, CA, USA
Psychiatry Res 160:247-55. 2008..However, increased mastery is associated with increased receptor sensitivity, and may therefore serve as a resource factor for improved health in this population... - The attenuating effect of personal mastery on the relations between stress and Alzheimer caregiver health: a five-year longitudinal analysisB T Mausbach
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0680, US
Aging Ment Health 11:637-44. 2007..002) and caregiver health (p=0.008), whereby mastery attenuated the effect of stress on these outcomes. We conclude that personal mastery appears to reduce the effects of stress on depression and health outcomes over time... - The moderating effect of personal mastery and the relations between stress and Plasminogen Activator Inhibitor-1 (PAI-1) antigenBrent T Mausbach
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0680, USA
Health Psychol 27:S172-9. 2008..e., negative life events and caregiving distress) and Plasminogen Activator Inhibitor (PAI)-1 antigen, an inhibitor of fibrinolysis implicated in the development of cardiovascular disease... - Association between chronic caregiving stress and impaired endothelial function in the elderlyBrent T Mausbach
Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0680, USA
J Am Coll Cardiol 55:2599-606. 2010..We examined the relationship between chronic caregiving stress and endothelial function... - Effects of placement and bereavement on psychological well-being and cardiovascular risk in Alzheimer's caregivers: a longitudinal analysisBrent T Mausbach
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0680, USA
J Psychosom Res 62:439-45. 2007..We examined the impact of Alzheimer caregiver transitions (i.e., placement and bereavement) on psychological outcomes and on plasma D-dimer levels, an end product of the coagulation cascade associated with increased cardiovascular risk... - Self-efficacy buffers the relationship between dementia caregiving stress and circulating concentrations of the proinflammatory cytokine interleukin-6Brent T Mausbach
Department of Psychiatry, University of California San Diego, San Diego, CA 92093 0680, USA
Am J Geriatr Psychiatry 19:64-71. 2011..The purpose of this study was to investigate the potential protective role of coping self-efficacy on the relationship between caregiving stress and circulating concentrations of IL-6... - Depressive symptoms predict norepinephrine response to a psychological stressor task in Alzheimer's caregiversBrent T Mausbach
Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0680, USA
Psychosom Med 67:638-42. 2005..The current study examined the relations between the level of depressive symptoms in spousal caregivers and the physiological response to a psychological stress task... - Avoidant coping partially mediates the relationship between patient problem behaviors and depressive symptoms in spousal Alzheimer caregiversBrent T Mausbach
Department of Psychiatry, University of California at San Diego, San Diego, California 92093 0680, USA
Am J Geriatr Psychiatry 14:299-306. 2006..The purpose of this study was to test a mediational model of the associations between patient problem behaviors, escape-avoidance coping, and depressive symptoms in Alzheimer caregivers... - Activity restriction and depression in medical patients and their caregivers: a meta-analysisBrent T Mausbach
Department of Psychiatry, University of California, San Diego, USA
Clin Psychol Rev 31:900-8. 2011..Assessment and treatment of activity restriction may be particularly helpful in preventing depression... - Is depression in Alzheimer's caregivers really due to activity restriction? A preliminary mediational test of the Activity Restriction ModelBrent T Mausbach
Department of Psychiatry 0680, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0680, USA
J Behav Ther Exp Psychiatry 39:459-66. 2008..29, p=0.031), accounting for 86% of this relationship. Behavioral interventions for depression might be particularly relevant for Alzheimer's caregivers to reduce activity restriction and, thus, depressive symptoms... - Stress-related reduction in personal mastery is associated with reduced immune cell beta2-adrenergic receptor sensitivityBrent T Mausbach
Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0680, U S A
Int Psychogeriatr 19:935-46. 2007..The purpose of this study was to investigate whether stress-related experience of depressive symptoms and reductions in personal mastery were related to alterations in ss2-adrenergic receptor sensitivity... - Sleep disturbance, norepinephrine, and D-dimer are all related in elderly caregivers of people with Alzheimer diseaseBrent T Mausbach
Department of Psychiatry, University of California, San Diego, CA 92093 0682, USA
Sleep 29:1347-52. 2006..In this study, we examined if sleep disturbance of elderly caregivers was associated with physiologic markers of cardiovascular risk, including plasma norepinephrine, epinephrine, and the hemostasis marker D-dimer... - Sensitivity and specificity of the UCSD Performance-based Skills Assessment (UPSA-B) for identifying functional milestones in schizophreniaBrent T Mausbach
Department of Psychiatry, University of California, San Diego, United States
Schizophr Res 132:165-70. 2011.... - Integration of the pleasant events and activity restriction models: development and validation of a "PEAR" model of negative outcomes in Alzheimer's caregiversBrent T Mausbach
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0680, USA
Behav Ther 42:78-88. 2011.... - The relationship between functional capacity and community responsibilities in middle-aged and older Latinos of Mexican origin with chronic psychosisVeronica Cardenas
Department of Psychiatry 0680, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0680, United States
Schizophr Res 98:209-16. 2008..e., UPSA scores) may be associated with increased capacity for greater community involvement in this population... - Dementia severity of the care receiver predicts procoagulant response in Alzheimer caregiversKirstin Aschbacher
Department of Psychiatry, School of Medicine, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
Am J Geriatr Psychiatry 14:694-703. 2006..Effect size estimates suggest that such D-dimer increases may have clinical implications, particularly among late-stage caregivers... - Personal mastery is associated with reduced sympathetic arousal in stressed Alzheimer caregiversSusan K Roepke
Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0680, USA
Am J Geriatr Psychiatry 16:310-7. 2008..This study examines the relationship between mastery and sympathetic arousal in elderly caregivers, as measured by norepinephrine (NE) reactivity to an acute psychological stressor... - Affective symptoms and intra-individual variability in the short-term course of cognitive functioning in bipolar disorderC A Depp
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0664, USA
Psychol Med 42:1409-16. 2012..Key questions are whether trajectories in symptoms covary with cognitive function and whether BD is associated with increased intra-individual variability in cognitive abilities... - Usefulness of the UCSD performance-based skills assessment (UPSA) for predicting residential independence in patients with chronic schizophreniaBrent T Mausbach
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
J Psychiatr Res 42:320-7. 2008..43, p=.015). The UPSA is a brief measure of functional capacity that predicts the ability of patients with schizophrenia to reside independently in the community... - The moderating effect of self-efficacy on intervention response in women family caregivers of older adults with dementiaYaron G Rabinowitz
Older Adult and Family Center, Stanford University School of Medicine, VA Palo Alto Health Care System, Palo Alto, CA, USA
Am J Geriatr Psychiatry 14:642-9. 2006..This study supports the use of self-efficacy as a screening tool for appropriate caregiver intervention assignment... - Combination of caregiving stress and hormone replacement therapy is associated with prolonged platelet activation to acute stress among postmenopausal womenKirstin Aschbacher
Department of Psychiatry, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093 0680, USA
Psychosom Med 69:910-7. 2007..Both HRT and the chronic stress of caregiving have been associated with increased cardiovascular risk, potentially through a mechanism of platelet hyperactivity... - Persistent versus transient depressive symptoms in relation to platelet hyperactivation: a longitudinal analysis of dementia caregiversKirstin Aschbacher
Department of Psychiatry, University of California, San Diego, USA
J Affect Disord 116:80-7. 2009..The primary objective was to investigate whether persistent depressive symptoms would relate to elevated platelet activation in response to acute psychological stress over a three-year period... - Effects of gender and dementia severity on Alzheimer's disease caregivers' sleep and biomarkers of coagulation and inflammationPaul J Mills
Department of Psychiatry, University of California at San Diego, La Jolla, CA, USA
Brain Behav Immun 23:605-10. 2009..This study examined the effects of caregiver gender and severity of the spouse's dementia on sleep, coagulation, and inflammation in the caregiver... - Performance-based and subjective measures of functioning in middle-aged and older adults with bipolar disorderColin A Depp
Department of Psychiatry, University of California, San Diego VA San Diego Healthcare System, 3350 La Jolla Village Drive 116A 1, San Diego, CA 92161, USA
J Nerv Ment Dis 197:471-5. 2009..Given its relative independence from symptoms, the UPSA may be useful in gauging the effectiveness of rehabilitation for bipolar disorder... - Measurement of functional capacity: a new approach to understanding functional differences and real-world behavioral adaptation in those with mental illnessThomas L Patterson
Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0680, USA
Annu Rev Clin Psychol 6:139-54. 2010..Limitations of existing methods of assessing functional capacity are discussed, and future areas of research are suggested... - Physical and mental health-related quality of life among older people with schizophreniaDavid P Folsom
University of California, San Diego, VA San Diego Healthcare System, 3350 La Jolla Village Drive, San Diego, CA 92161, USA
Schizophr Res 108:207-13. 2009..The objective of this study was to examine the relationship of age to both mental and physical aspects of HRQoL in individuals with schizophrenia as compared to normal comparison subjects (NCs)... - Neuropsychological substrates and everyday functioning implications of prospective memory impairment in schizophreniaElizabeth W Twamley
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive 0603, La Jolla, CA 92093 USA
Schizophr Res 106:42-9. 2008..Studies regarding the potential effectiveness of ProM-based remediation strategies to improve functional outcomes in schizophrenia are indicated... - Functional adaptation skills training (FAST): a randomized trial of a psychosocial intervention for middle-aged and older patients with chronic psychotic disordersThomas L Patterson
Department of Psychiatry 0680, University of California, San Diego, La Jolla, CA 92093 0680, USA
Schizophr Res 86:291-9. 2006..This study evaluated a psychosocial intervention designed to improve everyday living skills of middle-aged and older outpatients with chronic psychotic disorders... - Development and pilot testing of a new psychosocial intervention for older Latinos with chronic psychosisThomas L Patterson
Department of Psychiatry, University of California San Diego, USA
Schizophr Bull 31:922-30. 2005.... - Social competence and observer-rated social functioning in bipolar disorderColin A Depp
Stein Institute for Research on Aging, Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0664, USA
Bipolar Disord 12:843-50. 2010..We examined performance-based and observer-based ratings of social competence and functioning and assessed the contribution of symptoms and neurocognitive ability to social functioning in bipolar disorder... - Efficacy of a behavioral intervention for increasing safer sex behaviors in HIV-positive MSM methamphetamine users: results from the EDGE studyBrent T Mausbach
Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0680, USA
Drug Alcohol Depend 87:249-57. 2007..This study examined the efficacy of a behavioral intervention for increasing safer sex behaviors in the context of ongoing methamphetamine use in a sample of HIV-positive, methamphetamine-using MSM... - Effects of depressive and anxious symptoms on norepinephrine and platelet P-selectin responses to acute psychological stress among elderly caregiversKirstin Aschbacher
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, La Jolla CA 92093 0680, USA
Brain Behav Immun 22:493-502. 2008.... - Personal mastery attenuates the effect of caregiving stress on psychiatric morbidityBrent T Mausbach
Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093-0680, USA
J Nerv Ment Dis 194:132-4. 2006..22; p = 0.029), but not high (t[71] = -1.49; p = 0.140). These results suggest that caregivers with a greater sense of personal mastery may be protected from the negative effects of caregiver stress... - Development of a brief scale of everyday functioning in persons with serious mental illnessBrent T Mausbach
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0680, USA
Schizophr Bull 33:1364-72. 2007..Therefore, the UPSA-Brief may be a useful performance-based functional outcome scale... - Effective recruitment strategies for Latino and Caucasian dementia family caregivers in intervention researchDolores Gallagher-Thompson
Older Adult and Family Center, Stanford University School of Medicine, Department of Psychiatry, Palo Alto, CA, USA
Am J Geriatr Psychiatry 12:484-90. 2004..However, their participation in intervention research is disproportionately low. The authors compared the participant retention rates of three different recruitment strategies in a sample of Latino and Caucasian family caregivers... - Predictors of safer sex intentions and protected sex among heterosexual HIV-negative methamphetamine users: an expanded model of the Theory of Planned BehaviorBrent T Mausbach
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
AIDS Care 21:17-24. 2009..g., methamphetamine use). Effective interventions for increasing safer sex practices in methamphetamine user will likely include constructs from this model with augmentations to help reduce methamphetamine use... - Reducing emergency medical service use in patients with chronic psychotic disorders: results from the FAST intervention studyBrent T Mausbach
Department of Psychiatry 0680, University of California San Diego, La Jolla, CA 92093 0680, USA
Behav Res Ther 46:145-53. 2008..However, the long-term efficacy of the FAST intervention appears less clear. Future studies may want to provide more powerful maintenance sessions to encourage continued use of skills in patients' real-world settings... - Relationship between functional capacity and community responsibility in patients with schizophrenia: differences between independent and assisted living settingsBrent T Mausbach
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0680, USA
Community Ment Health J 44:385-91. 2008..Further, among participants residing in the community, functional capacity may predict level of responsibility... - Longitudinal platelet reactivity to acute psychological stress among older men and womenKirstin Aschbacher
Department of Psychiatry, University of California San Diego, La Jolla, CA, USA
Stress 12:426-33. 2009..The results demonstrate that laboratory acute stress tests continued to produce robust platelet reactivity on three activation markers among older adults over 3 years... - Efficacy of a behavioral intervention for increasing safer sex behaviors in HIV-negative, heterosexual methamphetamine users: results from the Fast-Lane StudyBrent T Mausbach
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0680, USA
Ann Behav Med 34:263-74. 2007..The risk of acquiring HIV is particularly high among persons who use methamphetamine, which is often associated with unprotected sex and high numbers of sexual partners... - Effect of Alzheimer caregiving stress and age on frailty markers interleukin-6, C-reactive protein, and D-dimerRoland von Kanel
Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital, Switzerland
J Gerontol A Biol Sci Med Sci 61:963-9. 2006..We hypothesized that, compatible with premature frailty, chronic stress and age are related in predicting inflammation and coagulation activity in Alzheimer caregivers... - Ethnicity and time to institutionalization of dementia patients: a comparison of Latina and Caucasian female family caregiversBrent T Mausbach
Older Adult and Family Center, Stanford University School of Medicine and Veterans Affairs Palo Alto Health Care System, Palo Alto, California, USA
J Am Geriatr Soc 52:1077-84. 2004..To compare rates of institutionalization of dementia patients cared for by Latina and Caucasian female caregivers and to explore which caregiver and care-recipient characteristics predicted institutionalization... - Measures of endothelial dysfunction in plasma of patients with posttraumatic stress disorderRoland von Kanel
Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital Berne, Switzerland
Psychiatry Res 158:363-73. 2008..This suggests one mechanism by which posttraumatic stress could contribute to atherosclerosis... - Increased Framingham Coronary Heart Disease Risk Score in dementia caregivers relative to non-caregiving controlsRoland von Kanel
Department of General Internal Medicine, Division of Psychosomatic Medicine, University Hospital, Berne, Switzerland
Gerontology 54:131-7. 2008..Elderly individuals who provide care to a spouse suffering from dementia bear an increased risk of coronary heart disease (CHD)... - The relationship between self-efficacy and cumulative health risk associated with health behavior patterns in female caregivers of elderly relatives with Alzheimer's dementiaYaron G Rabinowitz
Walter Reed Army Medical Center, Washington, DC, USA
J Aging Health 19:946-64. 2007..To promote caregiver well-being and to help caregivers persevere in their invaluable roles, personal resources that predict increased self-care and reduced health risk behaviors need to be identified... - The role of stress hormones in the relationship between resting blood pressure and coagulation activityPetra H Wirtz
Department of Clinical Psychology and Psychotherapy, University of Zurich, Switzerland
J Hypertens 24:2409-16. 2006..Independent of MBP, catecholamines were associated with procoagulant effects and cortisol reactivity dampened the acute procoagulant stress response... - Relation of autonomic activity to plasminogen activator inhibitor-1 plasma concentration and the role of body mass indexRoland von Kanel
Department of General Internal Medicine, University Hospital Berne, Switzerland
Blood Coagul Fibrinolysis 18:353-9. 2007..More apparent, higher BMI explained a significant proportion of the variance in the relationship between depressed sympathetic and parasympathetic activity and elevated plasma PAI-1 concentration... - Relation of morning serum cortisol to prothrombotic activity in women with stable coronary artery diseaseRoland von Kanel
Department of General Internal Medicine, University Hospital, Berne 3010, Switzerland
J Thromb Thrombolysis 25:165-72. 2008..We hypothesized a direct relationship between cortisol and hemostasis factors related to a prothrombotic state in coronary artery disease...
Research Grants
- Skills Training and Empowerment Program for Middle-Aged and Older Patients with PBrent Mausbach; Fiscal Year: 2009..Both groups will receive 6 months of booster sessions to reinforce functional gains. Group differences in functional outcomes will be determined based upon assessments made at baseline, 6-, 12-, and 18-months post-baseline. ..
- Skills Training and Empowerment Program for Middle-Aged and Older Patients with PBrent T Mausbach; Fiscal Year: 2010..Both groups will receive 6 months of booster sessions to reinforce functional gains. Group differences in functional outcomes will be determined based upon assessments made at baseline, 6-, 12-, and 18-months post-baseline. ..
- Pleasant Events and Moods: A Time-Series AnalysisBrent Mausbach; Fiscal Year: 2006..The remaining participants will receive no feedback. All participants will receive a one-month follow-up to determine if those receiving detailed feedback experience fewer negative emotions and more positive emotions. ..
- Reducing CVD Risk in Caregivers: A Brief Behavioral Activation InterventionBrent Mausbach; Fiscal Year: 2009....
- Reducing CVD Risk in Caregivers: A Brief Behavioral Activation InterventionBrent T Mausbach; Fiscal Year: 2010....