Theodora M Mauro

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Acidification in the epidermis and the role of secretory phospholipases
    Aegean Chan
    Dermatology Department University of California, San Francisco and San Francisco Veterans Affairs Medical Center San Francisco, CA USA
    Dermatoendocrinol 3:84-90. 2011
  2. ncbi request reprint CaR talk: the calcium receptor finds new places to park
    Theodora M Mauro
    Department of Dermatology, University of California at San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 127:991-2. 2007
  3. pmc Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators
    Yutaka Hatano
    Dermatology Service, Veterans Affairs Medical Center, University of California, San Francisco, CA, USA
    J Allergy Clin Immunol 125:160-9.e1-5. 2010
  4. pmc Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis
    Yutaka Hatano
    Dermatology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 129:1824-35. 2009
  5. pmc pH-regulated mechanisms account for pigment-type differences in epidermal barrier function
    Roshan Gunathilake
    Department of Dermatology, Veteran Affairs Medical Center, University of California San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 129:1719-29. 2009
  6. pmc Topical apigenin improves epidermal permeability barrier homoeostasis in normal murine skin by divergent mechanisms
    Maihua Hou
    Dermatology Service, Veterans Affairs Medical Center, and University of California San Francisco, San Francisco, CA, USA
    Exp Dermatol 22:210-5. 2013
  7. doi request reprint Topical peroxisome proliferator activated receptor activators accelerate postnatal stratum corneum acidification
    Joachim W Fluhr
    Dermatology and Medical Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 129:365-74. 2009
  8. pmc SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease
    Anna Celli
    Department of Dermatology, San Francisco Veterans Administration Medical Center, San Francisco, California 94121 1545, USA
    J Invest Dermatol 132:1188-95. 2012
  9. pmc Akt2 and SGK3 are both determinants of postnatal hair follicle development
    Theodora M Mauro
    Department of Dermatology, University of California, San Francisco, San Francisco, CA 94107 2140, USA
    FASEB J 23:3193-202. 2009
  10. pmc Focal adhesion kinase controls pH-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localization
    Dusko Ilic
    Dermatology Service, Veterans Affairs Medical Center, San Francisco, CA, USA
    Am J Pathol 170:2055-67. 2007

Research Grants

Collaborators

Detail Information

Publications27

  1. pmc Acidification in the epidermis and the role of secretory phospholipases
    Aegean Chan
    Dermatology Department University of California, San Francisco and San Francisco Veterans Affairs Medical Center San Francisco, CA USA
    Dermatoendocrinol 3:84-90. 2011
    ..Given their role in inflammatory dermatoses, such as psoriasis and atopic dermatitis, understanding this complex enzyme family can lead to novel, life-changing therapies...
  2. ncbi request reprint CaR talk: the calcium receptor finds new places to park
    Theodora M Mauro
    Department of Dermatology, University of California at San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 127:991-2. 2007
    ....
  3. pmc Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators
    Yutaka Hatano
    Dermatology Service, Veterans Affairs Medical Center, University of California, San Francisco, CA, USA
    J Allergy Clin Immunol 125:160-9.e1-5. 2010
    ..Additionally, some of these activators exhibit potent antihyperplastic and anti-inflammatory activity in irritant contact dermatitis and acute allergic contact dermatitis murine models...
  4. pmc Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis
    Yutaka Hatano
    Dermatology Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 129:1824-35. 2009
    ..These results provide direct evidence for the "outside-inside" pathogenesis of AD and further suggest that maintenance of an acidic SC pH could prevent the emergence of AD in humans...
  5. pmc pH-regulated mechanisms account for pigment-type differences in epidermal barrier function
    Roshan Gunathilake
    Department of Dermatology, Veteran Affairs Medical Center, University of California San Francisco, San Francisco, California 94121, USA
    J Invest Dermatol 129:1719-29. 2009
    ..These studies show marked pigment-type differences in epidermal structure and function that are pH driven...
  6. pmc Topical apigenin improves epidermal permeability barrier homoeostasis in normal murine skin by divergent mechanisms
    Maihua Hou
    Dermatology Service, Veterans Affairs Medical Center, and University of California San Francisco, San Francisco, CA, USA
    Exp Dermatol 22:210-5. 2013
    ..Apigenin could be useful for the prevention and treatment of skin disorders characterized by permeability barrier dysfunction, associated with reduced filaggrin levels and impaired antimicrobial defenses, such as atopic dermatitis...
  7. doi request reprint Topical peroxisome proliferator activated receptor activators accelerate postnatal stratum corneum acidification
    Joachim W Fluhr
    Dermatology and Medical Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 129:365-74. 2009
    ..Hence, PPARalpha activators might be useful to prevent or treat certain common neonatal dermatoses...
  8. pmc SERCA2-controlled Ca²+-dependent keratinocyte adhesion and differentiation is mediated via the sphingolipid pathway: a therapeutic target for Darier's disease
    Anna Celli
    Department of Dermatology, San Francisco Veterans Administration Medical Center, San Francisco, California 94121 1545, USA
    J Invest Dermatol 132:1188-95. 2012
    ....
  9. pmc Akt2 and SGK3 are both determinants of postnatal hair follicle development
    Theodora M Mauro
    Department of Dermatology, University of California, San Francisco, San Francisco, CA 94107 2140, USA
    FASEB J 23:3193-202. 2009
    ....
  10. pmc Focal adhesion kinase controls pH-dependent epidermal barrier homeostasis by regulating actin-directed Na+/H+ exchanger 1 plasma membrane localization
    Dusko Ilic
    Dermatology Service, Veterans Affairs Medical Center, San Francisco, CA, USA
    Am J Pathol 170:2055-67. 2007
    ..Thus, for plasma membrane localization in terminally differentiated keratinocytes, Na(+)/H(+) exchanger 1 requires an intact actin cytoskeleton, which is impaired in FAK-deficient cells...
  11. ncbi request reprint Functional consequences of a neutral pH in neonatal rat stratum corneum
    Joachim W Fluhr
    Dermatology and Medical Service, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 123:140-51. 2004
    ..The delay in acidification of neonatal SC results in abnormalities in permeability barrier homeostasis and SC integrity and are likely due to pH-induced modulations in enzyme activity...
  12. ncbi request reprint Local blockade of glucocorticoid activation reverses stress- and glucocorticoid-induced delays in cutaneous wound healing
    Jong Kyung Youm
    Department of Dermatology, Veterans Affairs Medical Center, San Francisco, California Northern California Institute for Research and Education, University of California, San Francisco, California
    Wound Repair Regen 21:715-22. 2013
    ..Local blockade or down-regulation of cutaneous GC activation could help enhance WH in various clinical settings. ..
  13. ncbi request reprint Stratum corneum acidification is impaired in moderately aged human and murine skin
    Eung Ho Choi
    Department of Dermatology, University of California San Francisco and Dermatology Service, Veteran s Administration Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 127:2847-56. 2007
    ..These abnormalities were normalized by exogenously acidifying the SC, suggesting a basis for the well-known acidification therapies that are widely used to treat the pathologic xerosis/eczema seen in moderately aged humans...
  14. pmc Tight junction properties change during epidermis development
    Anna Celli
    Dermatology Service, Veterans Affairs Medical Center, University of San Francisco, San Francisco, CA, USA
    Exp Dermatol 21:798-801. 2012
    ..These findings demonstrate that the role of TJ changes during epidermal development, and further suggest that the TJ-based and lipid-based epidermal permeability barriers are interdependent...
  15. ncbi request reprint Involucrin expression is decreased in Hailey-Hailey keratinocytes owing to increased involucrin mRNA degradation
    Karin M Aberg
    Department of Dermatology, University of California, San Francisco, California, USA
    J Invest Dermatol 127:1973-9. 2007
    ..This report provides new insights into differentiation defects in HHD and its relationship to Ca2+ signaling...
  16. pmc Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens
    Tiffany C Scharschmidt
    Department of Dermatology, Dermatology Service, Veterans Affairs Medical Center, University of California, San Francisco, Calif 94121, USA
    J Allergy Clin Immunol 124:496-506, 506.e1-6. 2009
    ..Yet additional acquired stressors might be necessary because the same mutations can result in a noninflammatory disorder, ichthyosis vulgaris...
  17. pmc Targeted disruption of the protein kinase SGK3/CISK impairs postnatal hair follicle development
    James A McCormick
    Departments of Medicine and Molecular and Cellular Pharmacology, University of California, San Francisco, CA 94143, USA
    Mol Biol Cell 15:4278-88. 2004
    ..These data establish a role for SGK3 in normal postnatal hair follicle development, possibly involving effects on beta-catenin/Lef-1-mediated gene transcription...
  18. ncbi request reprint Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores
    Martin J Behne
    Department of Dermatology, University of California, San Francisco, California, USA
    J Invest Dermatol 121:688-94. 2003
    ..In this report we localize the ATP2C1, demonstrate its physiologic relevance in mammalian cells, and measure intraorganelle Golgi Ca2+ in keratinocytes...
  19. ncbi request reprint NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging
    Martin J Behne
    Dermatology Service, Veterans Affairs Medical Center and Department of Dermatology, University of California, San Francisco, California 94121, USA
    J Biol Chem 277:47399-406. 2002
    ....
  20. ncbi request reprint Neonatal development of the stratum corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier function
    Martin J Behne
    Department of Dermatology, University of California San Francisco, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Invest Dermatol 120:998-1006. 2003
    ..Thus, full barrier competence appears to require the extension of acidification in microdomains from the SC/SG interface outward toward the skin surface in the immediate postnatal period...
  21. pmc Calcium, Orai1, and epidermal proliferation
    Daniel D Bikle
    Endocrine Research Unit, Department of Medicine, VA Medical Center, University of California, San Francisco, San Francisco, California, USA
    J Invest Dermatol 134:1506-8. 2014
    ..These findings reveal new interactions among various Ca(2+) signaling pathways and uncover novel functions for Ca(2+) signaling via the Orai1 channel. ..
  22. pmc Topical apigenin alleviates cutaneous inflammation in murine models
    Mao Qiang Man
    The Center for Skin Physiology Research, Dalian Skin Disease Hospital, Liaoning 116021, China Dermatology Service, Veterans Affairs Medical Center and Department of Dermatology, University of California, San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Evid Based Complement Alternat Med 2012:912028. 2012
    ..Together, these results suggest that topical application of apigenin could provide an alternative regimen for the treatment of dermatitis...
  23. ncbi request reprint Stratum corneum acidification in neonatal skin: secretory phospholipase A2 and the sodium/hydrogen antiporter-1 acidify neonatal rat stratum corneum
    Joachim W Fluhr
    Dermatology and Medical Service, Veterans Affairs Medical Center, and Department of Dermatology, University of California, San Francisco, 94121, USA
    J Invest Dermatol 122:320-9. 2004
    ..Conversely, the impaired acidification of neonatal SC, which has important functional and clinical consequences, can be explained by the relatively low activities of one or both of these mechanisms at birth...
  24. doi request reprint A topical Chinese herbal mixture improves epidermal permeability barrier function in normal murine skin
    Mona Man
    Dermatology Service, VAMC, and Department of Dermatology, University of California San Francisco, San Francisco, CA, USA Department of Dermatology, Yonsei University College of Medicine, Yongdong Severance Hospital, Seoul, Korea Department of Medicine, University of California San Francisco, San Francisco, CA, USA Dermatology, Hospital del Mar, UAB, Barcelone, Spain
    Exp Dermatol 20:285-8. 2011
    ....
  25. ncbi request reprint Activity of the hSPCA1 Golgi Ca2+ pump is essential for Ca2+-mediated Ca2+ response and cell viability in Darier disease
    Lucie Foggia
    INSERM U563, Purpan Hospital, Place du Dr Baylac, BP 2028, 31034 Toulouse CEDEX 3 and Université Paul Sabatier, 31062 Toulouse, France
    J Cell Sci 119:671-9. 2006
    ..Keratinocytes thus are unique among mammalian cells in their ability to use the Golgi Ca2+ store to mediate Ca2+ signaling...
  26. pmc Two-photon fluorescence lifetime imaging of the skin stratum corneum pH gradient
    Kerry M Hanson
    Laboratory for Fluorescence Dynamics, Department of Physics, University of Illinois, Urbana Champaign, Illinois 61801, USA
    Biophys J 83:1682-90. 2002
    ..The data definitively show that the stratum corneum acid mantle results from the presence of aqueous acidic pockets within the lipid-rich extracellular matrix...
  27. ncbi request reprint Serine protease activity and residual LEKTI expression determine phenotype in Netherton syndrome
    Jean Pierre Hachem
    Dienst Dermatologie, Academisch Ziekenhuis Vrije Universiteit Brussel, Brussels, Belgium
    J Invest Dermatol 126:1609-21. 2006
    ..These studies provide a mechanistic basis for phenotypic variations in NS, and describe compensatory mechanisms that permit survival of NS patients in the face of unrelenting SP attack...

Research Grants8

  1. ATP2A2-Regulated Keratinocyte Ca2+ Signaling Mechanisms
    Theodora Mauro; Fiscal Year: 2006
    ..The goal of this project is to define the pathogenic signaling pathways that lead to abnormal differentiation in Darier's disease, thus ameliorating the skin pathology of patients suffering from this condition. ..
  2. ATP2A2-Regulated Keratinocyte Ca2+ Signaling Mechanisms
    Theodora Mauro; Fiscal Year: 2007
    ..The goal of this project is to define the pathogenic signaling pathways that lead to abnormal differentiation in Darier's disease, thus ameliorating the skin pathology of patients suffering from this condition. ..
  3. ATP2A2-Regulated Keratinocyte Ca2+ Signaling Mechanisms
    Theodora Mauro; Fiscal Year: 2009
    ..The goal of this project is to define the pathogenic signaling pathways that lead to abnormal differentiation in Darier's disease, thus ameliorating the skin pathology of patients suffering from this condition. ..
  4. Aging Stratum Corneum pH and Barrier Function
    Theodora Mauro; Fiscal Year: 2009
    ..These studies will show that it is possible to identify and treat a major cause of skin disease in the aged. ..
  5. Aging Stratum Corneum pH and Barrier Function
    Theodora M Mauro; Fiscal Year: 2010
    ..These studies will show that it is possible to identify and treat a major cause of skin disease in the aged. ..
  6. ATP2A2-Regulated Keratinocyte Ca2+ Signaling Mechanisms
    Theodora M Mauro; Fiscal Year: 2010
    ..The goal of this project is to define the pathogenic signaling pathways that lead to abnormal differentiation in Darier's disease, thus ameliorating the skin pathology of patients suffering from this condition. ..