Michael Mauer

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Pancreas transplantation and reversal of diabetic nephropathy lesions
    Michael Mauer
    Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55454, USA
    Med Clin North Am 97:109-14. 2013
  2. doi request reprint Angiotensin II receptor blocker pretreatment of rats undergoing sudden renal ablation
    Hye Won Park
    Department of Pediatrics, Seoul National University Bundang Hospital, Sungnam, South Korea
    Nephrol Dial Transplant 27:107-14. 2012
  3. pmc Renal and retinal effects of enalapril and losartan in type 1 diabetes
    Michael Mauer
    Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    N Engl J Med 361:40-51. 2009
  4. ncbi request reprint ACE-I and ARBs in early diabetic nephropathy
    Michael Mauer
    MMC 491, 420 SE Delaware St, Minneapolis, MN 55455, USA
    J Renin Angiotensin Aldosterone Syst 3:262-9. 2002
  5. ncbi request reprint Implications of early renal changes in Fabry disease
    Michael Mauer
    Department of Pediatrics, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Clin Ther 30:S40. 2008
  6. ncbi request reprint Cellular basis of diabetic nephropathy: II. The transforming growth factor-beta system and diabetic nephropathy lesions in type 1 diabetes
    Chunmei Huang
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Diabetes 51:3577-81. 2002
  7. ncbi request reprint The early natural history of nephropathy in Type 1 Diabetes: III. Predictors of 5-year urinary albumin excretion rate patterns in initially normoalbuminuric patients
    Julia M Steinke
    Division of Pediatric Nephrology, Department of Pediatrics, University of Minnesota, 420 Delaware St, SE, MMC 491, Minneapolis, MN 55455, USA
    Diabetes 54:2164-71. 2005
  8. ncbi request reprint Glomerulotubular junction abnormalities are associated with proteinuria in type 1 diabetes
    Behzad Najafian
    Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    J Am Soc Nephrol 17:S53-60. 2006
  9. pmc Angiotensin II blockade in kidney transplant recipients
    Hassan N Ibrahim
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Minnesota, Minneapolis, MN 55414, USA
    J Am Soc Nephrol 24:320-7. 2013
  10. ncbi request reprint Low glomerular filtration rate in normoalbuminuric type 1 diabetic patients: an indicator of more advanced glomerular lesions
    M Luiza Caramori
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Diabetes 52:1036-40. 2003

Collaborators

Detail Information

Publications34

  1. pmc Pancreas transplantation and reversal of diabetic nephropathy lesions
    Michael Mauer
    Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55454, USA
    Med Clin North Am 97:109-14. 2013
    ..These studies also showed that tubulointerstitial remodeling was also possible...
  2. doi request reprint Angiotensin II receptor blocker pretreatment of rats undergoing sudden renal ablation
    Hye Won Park
    Department of Pediatrics, Seoul National University Bundang Hospital, Sungnam, South Korea
    Nephrol Dial Transplant 27:107-14. 2012
    ..Subtotal nephrectomy (N) in rats results in progressive hypertension, proteinuria and renal lesions. Renin-angiotensin system blockade initiated at N prevents these changes; treatments failing to reduce hypertension and proteinuria do not...
  3. pmc Renal and retinal effects of enalapril and losartan in type 1 diabetes
    Michael Mauer
    Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    N Engl J Med 361:40-51. 2009
    ..Nephropathy and retinopathy remain important complications of type 1 diabetes. It is unclear whether their progression is slowed by early administration of drugs that block the renin-angiotensin system...
  4. ncbi request reprint ACE-I and ARBs in early diabetic nephropathy
    Michael Mauer
    MMC 491, 420 SE Delaware St, Minneapolis, MN 55455, USA
    J Renin Angiotensin Aldosterone Syst 3:262-9. 2002
    ....
  5. ncbi request reprint Implications of early renal changes in Fabry disease
    Michael Mauer
    Department of Pediatrics, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Clin Ther 30:S40. 2008
  6. ncbi request reprint Cellular basis of diabetic nephropathy: II. The transforming growth factor-beta system and diabetic nephropathy lesions in type 1 diabetes
    Chunmei Huang
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Diabetes 51:3577-81. 2002
    ..Reduced LTBP-1 mRNA expression in SFs from slow-track patients may reflect genetically determined DN protection and suggests that LTBP-1 may be involved in the pathogenesis of DN through the regulation of TGF-beta activity...
  7. ncbi request reprint The early natural history of nephropathy in Type 1 Diabetes: III. Predictors of 5-year urinary albumin excretion rate patterns in initially normoalbuminuric patients
    Julia M Steinke
    Division of Pediatric Nephrology, Department of Pediatrics, University of Minnesota, 420 Delaware St, SE, MMC 491, Minneapolis, MN 55455, USA
    Diabetes 54:2164-71. 2005
    ..Since 64% of the patients that developed microalbuminuria reverted to normoalbuminuria, the risk of diabetic nephropathy as defined by current microalbuminuria criteria is unclear...
  8. ncbi request reprint Glomerulotubular junction abnormalities are associated with proteinuria in type 1 diabetes
    Behzad Najafian
    Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    J Am Soc Nephrol 17:S53-60. 2006
    ..Moreover, nonlinear models provide better fit for structural-functional relationships in patients with type 1 diabetes...
  9. pmc Angiotensin II blockade in kidney transplant recipients
    Hassan N Ibrahim
    Division of Renal Diseases and Hypertension, Department of Medicine, University of Minnesota, Minneapolis, MN 55414, USA
    J Am Soc Nephrol 24:320-7. 2013
    ..99; P=0.05), but this finding requires validation. In conclusion, treatment with losartan did not lead to a statistically significant reduction in a composite of interstitial expansion or ESRD from IF/TA in kidney transplant recipients...
  10. ncbi request reprint Low glomerular filtration rate in normoalbuminuric type 1 diabetic patients: an indicator of more advanced glomerular lesions
    M Luiza Caramori
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Diabetes 52:1036-40. 2003
    ..For these reasons, we suggest that regular measurements of GFR be performed in long-standing normoalbuminuric type 1 diabetic female diabetic patients, especially in those with retinopathy or hypertension...
  11. ncbi request reprint Cellular basis of diabetic nephropathy: IV. Antioxidant enzyme mRNA expression levels in skin fibroblasts of type 1 diabetic sibling pairs
    Maria Luiza Caramori
    Department of Pediatrics, University of Minnesota, M D 420 Delaware Street S E, Mayo Mail Code 491, Minneapolis, MN 55455, USA
    Nephrol Dial Transplant 21:3122-6. 2006
    ..Blunted cultured skin fibroblast (SF) antioxidant enzyme responses to hyperglycaemia are associated with diabetic nephropathy risk. The present study explores whether this association is, at least in part, genetically determined...
  12. ncbi request reprint Lessons learned from studies of the natural history of diabetic nephropathy in young type 1 diabetic patients
    Julia M Steinke
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Pediatr Endocrinol Rev 5:958-63. 2008
    ..The longitudinal structural studies are still in analysis and this paper will mainly review the cross sectional studies that have been completed to date...
  13. pmc Gene expression differences in skin fibroblasts in identical twins discordant for type 1 diabetes
    M Luiza Caramori
    Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
    Diabetes 61:739-44. 2012
    ....
  14. ncbi request reprint Glomerular structure in the normal human kidney: differences between living and cadaver donors
    M Luiza Caramori
    Department of Pediatrics, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    J Am Soc Nephrol 14:1901-3. 2003
    ..This study suggests that the normal values for glomerular structure should be derived only from living kidney donor tissues...
  15. ncbi request reprint Enhancing the predictive value of urinary albumin for diabetic nephropathy
    M Luiza Caramori
    Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Am Soc Nephrol 17:339-52. 2006
    ..Thus, although further research in DN biomarkers and predictors is greatly needed, a careful integrated evaluation of currently available parameters can improve our ability to predict DN risk in individual patients...
  16. pmc Benefits of Renin-Angiotensin blockade on retinopathy in type 1 diabetes vary with glycemic control
    Tasma Harindhanavudhi
    Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    Diabetes Care 34:1838-42. 2011
    ..In the current study, we evaluate whether glycemic control influenced the benefit of RAS blockade on DR progression in type 1 diabetic patients...
  17. pmc Having one kidney does not accelerate the rate of development of diabetic nephropathy lesions in type 1 diabetic patients
    Shirley Chang
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Diabetes 57:1707-11. 2008
    ..This study investigated whether the rate of development of diabetic nephropathy lesions was different in type 1 diabetic patients with a single (transplanted) kidney compared with patients with two (native) kidneys...
  18. ncbi request reprint The early natural history of nephropathy in type 1 diabetes: I. Study design and baseline characteristics of the study participants
    Michael Mauer
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Diabetes 51:1572-9. 2002
    ..The role of these and other variables in determining the development rate of the early lesions of DN over the 5 years between biopsies is the central issue under study...
  19. ncbi request reprint Atubular glomeruli and glomerulotubular junction abnormalities in diabetic nephropathy
    Behzad Najafian
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    J Am Soc Nephrol 14:908-17. 2003
    ..05). Thus, AG and glomerulotubular junction abnormalities may be important in the development and progression of DN...
  20. doi request reprint Progression of diabetic nephropathy in type 1 diabetic patients
    Behzad Najafian
    MMC 76 Mayo, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Diabetes Res Clin Pract 83:1-8. 2009
    ..e., renal pathology develops in clinical silence but, once established, leads to proteinuria and GFR decline...
  21. ncbi request reprint Diabetic nephropathy is associated with gene expression levels of oxidative phosphorylation and related pathways
    Chunmei Huang
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Diabetes 55:1826-31. 2006
    ..Whether these findings reflect inherent genetic cellular characteristics, "cell memory," or both requires further study...
  22. ncbi request reprint Diabetes and nephropathy
    M Luiza Caramori
    Endocrine Division, Universidade Federal do Rio Grande do Sul, Brazil and bDepartment of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Curr Opin Nephrol Hypertens 12:273-82. 2003
    ..Thus, research into diabetic nephropathy pathophysiology that could lead to new treatment approaches is urgently needed and this review aims to summarize the work performed in this area in the past year...
  23. pmc Albumin excretion rate in normal adolescents: relation to insulin resistance and cardiovascular risk factors and comparisons to type 1 diabetes mellitus patients
    Erin Rademacher
    University of Minnesota, Department of Pediatrics, MMC 491, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Clin J Am Soc Nephrol 3:998-1005. 2008
    ....
  24. pmc Microalbuminuria in patients with cystic fibrosis
    Melanie Lind-Ayres
    Department of Pediatric Endocrinology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
    Diabetes Care 34:1526-8. 2011
    ..We investigated transient (TMA) and persistent (PMA) microalbuminuria in CF patients to resolve these contradictory findings...
  25. ncbi request reprint Cellular basis of diabetic nephropathy: 1. Study design and renal structural-functional relationships in patients with long-standing type 1 diabetes
    M Luiza Caramori
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Diabetes 51:506-13. 2002
    ..Given that normoalbuminuric patients may have advanced glomerulopathy, the selection of slow-track patients based on glomerular structure may better identify protected patients than AER alone...
  26. ncbi request reprint Comparison of methods for counting cells in the mouse glomerulus
    John M Basgen
    Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota, USA
    Nephron Exp Nephrol 103:e139-48. 2006
    ..In this study, we compared the disector/fractionator and Weibel-Gomez methods to identify a practical alternative for the time-consuming Exhaustive Count method...
  27. ncbi request reprint Urinary albumin as an indicator of diabetic nephropathy lesions in Japanese type 2 diabetic patients
    Tatsumi Moriya
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis 55455, USA
    Nephron 91:292-9. 2002
    ....
  28. ncbi request reprint An increase in the cell component of the cortical interstitium antedates interstitial fibrosis in type 1 diabetic patients
    Avi Katz
    Department of Pediatrics, University of Minnesota, Minneapolis 55455 0392, USA
    Kidney Int 61:2058-66. 2002
    ..However, the interstitial elements that constitute interstitial expansion in DN are unknown and are the subject of this report...
  29. ncbi request reprint Estimating mean glomerular volume using two arbitrary parallel sections
    Behzad Najafian
    Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    J Am Soc Nephrol 13:2697-705. 2002
    ..Thus, the 2-profile method is a practical alternative to the disector/Cavalieri method for estimating MGV, especially in small samples and blocks with limited residual tissue...
  30. ncbi request reprint Cat-scratch disease relapse in a kidney transplant recipient
    Michelle N Rheault
    Department of Pediatrics, University of Minnesota, Minneapolis, MN 55455, USA
    Pediatr Transplant 11:105-9. 2007
    ..We review the diagnosis and treatment of this uncommon infection in the organ transplant population...
  31. ncbi request reprint Glomerular structural factors in progression of congenital nephrotic syndrome
    Abhay N Vats
    Department of Pediatrics, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Pediatr Nephrol 18:234-40. 2003
    ..Thus atubular glomeruli may play an important role in disease progression in CNF, as it is associated with a progressive decrease in hypertrophied "normal" glomeruli and an increase in largely atubular microcystic glomeruli...
  32. pmc GFR-estimating models in kidney transplant recipients on a steroid-free regimen
    Aleksandra Kukla
    Division of Renal Diseases and Hypertension, University of Minnesota, Minneapolis, MN, USA
    Nephrol Dial Transplant 25:1653-61. 2010
    ..How to best estimate glomerular filtration rate (GFR) in kidney transplant recipients on steroid-free immunosuppression has not been established...
  33. pmc Renal lesions predict progression of diabetic nephropathy in type 1 diabetes
    M Luiza Caramori
    Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA
    J Am Soc Nephrol 24:1175-81. 2013
    ..In conclusion, careful quantitative assessment of kidney biopsies in normoalbuminuric patients with type 1 diabetes adds substantially to the prediction of progression to clinical diabetic nephropathy...
  34. ncbi request reprint Idiopathic intracranial hypertension immediately after kidney transplantation in a pediatric recipient
    Sookkasem Khositseth
    Division of Pediatric Nephrology, Department of Pediatrics, University of Minnesota, Minneapolis 55455, USA
    Pediatr Nephrol 19:1416-7. 2004
    ..Awareness of this possibility could lead to earlier diagnosis and treatment of children with similar risk factors...

Research Grants28

  1. RENIN ANGIOTENSIN SYSTEM BLOCKAGE--DIABETIC NEPHROPATHY
    S Mauer; Fiscal Year: 2003
    ..Support for other costs is being sought from the Medical Research Council of Canada, with additional support from Merck, Inc. USA. ..
  2. RENAL AND CELLULAR STUDIES IN TYPE I DIABETIC PATIENTS
    S Mauer; Fiscal Year: 2003
    ..Skin fibroblasts from nondiabetic identical twins will answer whether hyperglycemia is necessary for the expression of cellular markers of DN risk. ..
  3. Proteomics in Type 1 Diabetes and its Complications
    S Mauer; Fiscal Year: 2005
    ..These studies could provide surrogate markers of DN and TIDM risk and provide insights into the pathogenesis of TIDM and its renal complications. ..
  4. Renal & Cellular Studies in Type 1 Diabetic Patients
    S Mauer; Fiscal Year: 2007
    ..These studies will provide markers and predictors of DN risk, determine if these are genetically regulated or dependent on prior exposure to D, and identify DN pathogenetic pathways. ..
  5. Mitochondrial and Oxidative Stress in Type 1 Diabetes
    S Mauer; Fiscal Year: 2007
    ....
  6. Renin Angiotensin System Blockage-DN (RASS)
    S Mauer; Fiscal Year: 2007
    ..Ancillary studies will evaluate the effects of treatment group on the development and progression of diabetic retinopathy and will develop predictors of study participants' compliance. ..