Robert L Mauck

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. Bonnevie E, Mauck R. Physiology and Engineering of the Graded Interfaces of Musculoskeletal Junctions. Annu Rev Biomed Eng. 2018;20:403-429 pubmed publisher
  2. Driscoll T, Cosgrove B, Heo S, Shurden Z, Mauck R. Cytoskeletal to Nuclear Strain Transfer Regulates YAP Signaling in Mesenchymal Stem Cells. Biophys J. 2015;108:2783-93 pubmed publisher
    ..g., ERK signaling) can be activated in the absence of nuclear strain transfer, cytoskeletal strain transfer to the nucleus is essential for activation of the YAP/TAZ pathway with stretch. ..
  3. Martin J, Milby A, Ikuta K, Poudel S, Pfeifer C, Elliott D, et al. A radiopaque electrospun scaffold for engineering fibrous musculoskeletal tissues: Scaffold characterization and in vivo applications. Acta Biomater. 2015;26:97-104 pubmed publisher
    ..In this work, we describe a radiopaque nanofibrous scaffold that can be visualized radiographically in both small and large animal models and serve as a framework for the development of an engineered fibrous tissue. ..
  4. Fisher M, Henning E, Söegaard N, Bostrom M, Esterhai J, Mauck R. Engineering meniscus structure and function via multi-layered mesenchymal stem cell-seeded nanofibrous scaffolds. J Biomech. 2015;48:1412-9 pubmed publisher
    ..These multi-layer constructs may serve as functional substitutes for the meniscus as well as test beds to understand the complex mechanical principles that enable meniscus function. ..
  5. Mauck R, Burdick J. From repair to regeneration: biomaterials to reprogram the meniscus wound microenvironment. Ann Biomed Eng. 2015;43:529-42 pubmed publisher
    ..Overall, these examples will illustrate how emergent features within a biomaterial can be tuned to manipulate and harness the local tissue microenvironment in order to promote robust regeneration. ..
  6. Qu F, Pintauro M, Haughan J, Henning E, Esterhai J, Schaer T, et al. Repair of dense connective tissues via biomaterial-mediated matrix reprogramming of the wound interface. Biomaterials. 2015;39:85-94 pubmed publisher
  7. Kim D, Martin J, Elliott D, Smith L, Mauck R. Phenotypic stability, matrix elaboration and functional maturation of nucleus pulposus cells encapsulated in photocrosslinkable hyaluronic acid hydrogels. Acta Biomater. 2015;12:21-9 pubmed publisher
    ..These findings support the use of HA-based hydrogels for NP tissue engineering and cellular therapies directed at restoration or replacement of the endogenous NP. ..
  8. Farrell M, Shin J, Smith L, Mauck R. Functional consequences of glucose and oxygen deprivation on engineered mesenchymal stem cell-based cartilage constructs. Osteoarthritis Cartilage. 2015;23:134-42 pubmed publisher
    ..These findings suggest that pre-selection of subpopulations that are resilient to metabolic challenge may improve in vivo outcomes. ..
  9. Farrell M, Fisher M, HUANG A, Shin J, Farrell K, Mauck R. Functional properties of bone marrow-derived MSC-based engineered cartilage are unstable with very long-term in vitro culture. J Biomech. 2014;47:2173-82 pubmed publisher

More Information

Publications17

  1. Pfeifer C, Fisher M, Carey J, Mauck R. Impact of guidance documents on translational large animal studies of cartilage repair. Sci Transl Med. 2015;7:310re9 pubmed publisher
    ..264 to 0.50). Given that improved adherence would expedite translation, we discuss the reasons for poor adherence and outline approaches to increase and promote their more widespread adoption. ..
  2. Martin J, Milby A, Chiaro J, Kim D, Hebela N, Smith L, et al. Translation of an engineered nanofibrous disc-like angle-ply structure for intervertebral disc replacement in a small animal model. Acta Biomater. 2014;10:2473-81 pubmed publisher
    ..These findings establish a new in vivo platform in which to evaluate and optimize the design of functional disc replacements. ..
  3. Gorth D, Martin J, Dodge G, Elliott D, Malhotra N, Mauck R, et al. In vivo retention and bioactivity of IL-1ra microspheres in the rat intervertebral disc: a preliminary investigation. J Exp Orthop. 2014;1:15 pubmed publisher
    ..Microspheres can successfully be delivered to the disc in vivo and retained for a clinically relevant time frame. IL-1ra released from microspheres can effectively prevent IL-1β-induced NP glycosaminoglycan loss in vivo. ..
  4. Heo S, Han W, Szczesny S, Cosgrove B, Elliott D, Lee D, et al. Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells. Biophys J. 2016;111:864-874 pubmed publisher
  5. Qu F, Li Q, Wang X, Cao X, Zgonis M, Esterhai J, et al. Maturation State and Matrix Microstructure Regulate Interstitial Cell Migration in Dense Connective Tissues. Sci Rep. 2018;8:3295 pubmed publisher
    ..By addressing the inherent limitations to repair imposed by the mature ECM, these studies may define new clinical strategies to promote repair of damaged dense connective tissues in adults. ..
  6. Gorth D, Mauck R, Chiaro J, Mohanraj B, Hebela N, Dodge G, et al. IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1?-mediated degradation of nucleus pulposus in vitro. Arthritis Res Ther. 2012;14:R179 pubmed publisher
    ..Ongoing studies are focusing on testing IL-1ra microspheres in an in vivo model of disc degeneration, as a prelude to clinical translation. ..
  7. Szczesny S, Mauck R. The Nuclear Option: Evidence Implicating the Cell Nucleus in Mechanotransduction. J Biomech Eng. 2017;139: pubmed publisher
  8. Kim M, Farrell M, Steinberg D, Burdick J, Mauck R. Enhanced nutrient transport improves the depth-dependent properties of tri-layered engineered cartilage constructs with zonal co-culture of chondrocytes and MSCs. Acta Biomater. 2017;58:1-11 pubmed publisher
    ..These constructs hold promise for restoring native tissue structure and function, and may be beneficial in terms of zone-to-zone integration with adjacent host tissue and providing more appropriate strain transfer after implantation. ..