Robert L Mauck
Affiliation: University of Pennsylvania
- Pfeifer C, Fisher M, Carey J, Mauck R. Impact of guidance documents on translational large animal studies of cartilage repair. Sci Transl Med. 2015;7:310re9 pubmed publisher..264 to 0.50). Given that improved adherence would expedite translation, we discuss the reasons for poor adherence and outline approaches to increase and promote their more widespread adoption. ..
- Martin J, Milby A, Chiaro J, Kim D, Hebela N, Smith L, et al. Translation of an engineered nanofibrous disc-like angle-ply structure for intervertebral disc replacement in a small animal model. Acta Biomater. 2014;10:2473-81 pubmed publisher..These findings establish a new in vivo platform in which to evaluate and optimize the design of functional disc replacements. ..
- Gorth D, Martin J, Dodge G, Elliott D, Malhotra N, Mauck R, et al. In vivo retention and bioactivity of IL-1ra microspheres in the rat intervertebral disc: a preliminary investigation. J Exp Orthop. 2014;1:15 pubmed publisher..Microspheres can successfully be delivered to the disc in vivo and retained for a clinically relevant time frame. IL-1ra released from microspheres can effectively prevent IL-1Î²-induced NP glycosaminoglycan loss in vivo. ..
- Qu F, Li Q, Wang X, Cao X, Zgonis M, Esterhai J, et al. Maturation State and Matrix Microstructure Regulate Interstitial Cell Migration in Dense Connective Tissues. Sci Rep. 2018;8:3295 pubmed publisher..By addressing the inherent limitations to repair imposed by the mature ECM, these studies may define new clinical strategies to promote repair of damaged dense connective tissues in adults. ..
- Gorth D, Mauck R, Chiaro J, Mohanraj B, Hebela N, Dodge G, et al. IL-1ra delivered from poly(lactic-co-glycolic acid) microspheres attenuates IL-1?-mediated degradation of nucleus pulposus in vitro. Arthritis Res Ther. 2012;14:R179 pubmed publisher..Ongoing studies are focusing on testing IL-1ra microspheres in an in vivo model of disc degeneration, as a prelude to clinical translation. ..
- Kim M, Farrell M, Steinberg D, Burdick J, Mauck R. Enhanced nutrient transport improves the depth-dependent properties of tri-layered engineered cartilage constructs with zonal co-culture of chondrocytes and MSCs. Acta Biomater. 2017;58:1-11 pubmed publisher..These constructs hold promise for restoring native tissue structure and function, and may be beneficial in terms of zone-to-zone integration with adjacent host tissue and providing more appropriate strain transfer after implantation. ..