Michael Matthay

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Randomized clinical trial of activated protein C for the treatment of acute lung injury
    Kathleen D Liu
    Division of Nephrology and Critical Care Medicine, Department of Medicine, Box 0532, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    Am J Respir Crit Care Med 178:618-23. 2008
  2. pmc Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction--a randomised placebo-controlled trial (KARE): study protocol
    Laurence J M Cross
    Centre for Infection and Immunity, The Queen s University of Belfast, Health Sciences Building, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland
    Trials 14:51. 2013
  3. pmc Clinical review: Thinking outside the box--an iconoclastic view of current practice
    Mervyn Singer
    Bloomsbury Institute of Intensive Care Medicine, Department of Medicine, University College London, London WC1E 6BT, UK
    Crit Care 15:225. 2011
  4. pmc Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study
    Magda Cepkova
    Cardiovascular Research Institute, University of California, San Francisco, CA, 94143, USA
    Ann Intensive Care 1:18. 2011
  5. pmc The acute respiratory distress syndrome
    Michael A Matthay
    Cardiovascular Research Institute and Departments of Medicine and Anesthesia, UCSF, San Francisco, CA, USA
    J Clin Invest 122:2731-40. 2012
  6. pmc Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes
    Anna Krasnodembskaya
    Cardiovascular Research Institute and Department of Anesthesiology, University of California San Francisco, 505 Parnassus Ave, CA 94143, USA
    Am J Physiol Lung Cell Mol Physiol 302:L1003-13. 2012
  7. pmc Prognostic value of pulmonary dead space in patients with the acute respiratory distress syndrome
    Michael A Matthay
    Department of Medicine and Cardiovascular Research Institute at University of California, San Francisco, 505 Parnassus Avenue, M 917, San Francisco, CA 94143 0624, USA
    Crit Care 15:185. 2011
  8. pmc Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, T 1218 MCN Nashville, TN 37221, USA
    Crit Care 15:R86. 2011
  9. pmc Assessing the quantity of pulmonary edema in critically ill children
    Daniel F McAuley
    Regional Intensive Care Unit, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, N Ireland
    Crit Care 14:189. 2010
  10. pmc Inhaled activated protein C: a novel therapy for acute lung injury?
    Kathleen D Liu
    Division of Nephrology and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0624, USA
    Crit Care 13:150. 2009

Research Grants

  1. RESOLUTION OF CLINICAL LUNG INJURY
    Michael Matthay; Fiscal Year: 2001
  2. MECHANISMS OF ALVEOLAR EPITHELIAL FLUID CLEARANCE
    Michael Matthay; Fiscal Year: 2002
  3. RESOLUTION OF CLINICAL LUNG INJURY
    Michael Matthay; Fiscal Year: 2002
  4. MECHANISMS OF ALVEOLAR EPITHELIAL FLUID CLEARANCE
    Michael Matthay; Fiscal Year: 2003
  5. RESOLUTION OF CLINICAL LUNG INJURY
    Michael Matthay; Fiscal Year: 2003
  6. MECHANISMS OF ALVEOLAR EPITHELIAL FLUID CLEARANCE
    Michael Matthay; Fiscal Year: 2004
  7. RESOLUTION OF CLINICAL LUNG INJURY
    Michael Matthay; Fiscal Year: 2004
  8. MECHANISMS OF ALVEOLAR EPITHELIAL FLUID CLEARANCE
    Michael Matthay; Fiscal Year: 2005
  9. RESOLUTION OF CLINICAL LUNG INJURY
    Michael Matthay; Fiscal Year: 2005
  10. MECHANISMS OF ALVEOLAR EPITHELIAL FLUID CLEARANCE
    Michael Matthay; Fiscal Year: 2007

Detail Information

Publications101 found, 100 shown here

  1. pmc Randomized clinical trial of activated protein C for the treatment of acute lung injury
    Kathleen D Liu
    Division of Nephrology and Critical Care Medicine, Department of Medicine, Box 0532, University of California, San Francisco, San Francisco, CA 94143 0532, USA
    Am J Respir Crit Care Med 178:618-23. 2008
    ..Plasma protein C levels are decreased in patients with acute lung injury and are associated with higher mortality and fewer ventilator-free days...
  2. pmc Keratinocyte growth factor in acute lung injury to reduce pulmonary dysfunction--a randomised placebo-controlled trial (KARE): study protocol
    Laurence J M Cross
    Centre for Infection and Immunity, The Queen s University of Belfast, Health Sciences Building, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland
    Trials 14:51. 2013
    ....
  3. pmc Clinical review: Thinking outside the box--an iconoclastic view of current practice
    Mervyn Singer
    Bloomsbury Institute of Intensive Care Medicine, Department of Medicine, University College London, London WC1E 6BT, UK
    Crit Care 15:225. 2011
    ..This article is a synopsis of a roundtable meeting held in Brussels in March 2010 designed specifically to confront doctrine with reasoned scientific argument, and to propose new ideas for advancing critical care practices and outcomes...
  4. pmc Clinical significance of elevated B-type natriuretic peptide in patients with acute lung injury with or without right ventricular dilatation: an observational cohort study
    Magda Cepkova
    Cardiovascular Research Institute, University of California, San Francisco, CA, 94143, USA
    Ann Intensive Care 1:18. 2011
    ..abstract:..
  5. pmc The acute respiratory distress syndrome
    Michael A Matthay
    Cardiovascular Research Institute and Departments of Medicine and Anesthesia, UCSF, San Francisco, CA, USA
    J Clin Invest 122:2731-40. 2012
    ..Improved survival has been achieved with the use of lung-protective ventilation. Future progress will depend on developing novel therapeutics that can facilitate and enhance lung repair...
  6. pmc Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytes
    Anna Krasnodembskaya
    Cardiovascular Research Institute and Department of Anesthesiology, University of California San Francisco, 505 Parnassus Ave, CA 94143, USA
    Am J Physiol Lung Cell Mol Physiol 302:L1003-13. 2012
    ..Thus intravenous MSC increased survival from gram-negative peritoneal sepsis, in part by a monocyte-dependent increase in bacterial phagocytosis...
  7. pmc Prognostic value of pulmonary dead space in patients with the acute respiratory distress syndrome
    Michael A Matthay
    Department of Medicine and Cardiovascular Research Institute at University of California, San Francisco, 505 Parnassus Avenue, M 917, San Francisco, CA 94143 0624, USA
    Crit Care 15:185. 2011
    ....
  8. pmc Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid status
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, T 1218 MCN Nashville, TN 37221, USA
    Crit Care 15:R86. 2011
    ..The VPW was studied in ALI patients to determine the correlation between VPW and intravascular pressure measurements and whether VPW could predict fluid status...
  9. pmc Assessing the quantity of pulmonary edema in critically ill children
    Daniel F McAuley
    Regional Intensive Care Unit, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, N Ireland
    Crit Care 14:189. 2010
    ..The present commentary briefly reviews the potential role and limitations of extravascular lung water measurement in critically ill children...
  10. pmc Inhaled activated protein C: a novel therapy for acute lung injury?
    Kathleen D Liu
    Division of Nephrology and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0624, USA
    Crit Care 13:150. 2009
    ..Future studies are needed to determine plasma and airspace APC levels when administered by the inhaled route, and to determine if inhaled APC has a similar effect in other models of ALI...
  11. pmc Protein C as a surrogate end-point for clinical trials of sepsis
    Kathleen D Liu
    Divisions of Nephrology and Critical Care Medicine, Department of Medicine, University of California, 521 Parnassus Ave, C443, San Francisco, CA 94143, USA
    Crit Care 12:139. 2008
    ..Only protein C had acceptable performance characteristics as a type 2 biomarker, or surrogate end-point. The utility of protein C as a surrogate end-point for studies of severe sepsis must be validated in future prospective studies...
  12. pmc Biological markers of lung injury before and after the institution of positive pressure ventilation in patients with acute lung injury
    Magda Cepkova
    The Cardiovascular Research Institute and the Departments of Medicine and Anesthesia, University of California, San Francisco, 505 Parnassus Avenue, M917, San Francisco, CA 94143 0624, USA
    Crit Care 10:R126. 2006
    ....
  13. pmc Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injury
    Dana McClintock
    Cardiovascular Research Institute, 505 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143, USA
    Crit Care 12:R41. 2008
    ..We measured plasma markers of inflammation, coagulation and fibrinolysis simultaneously to assess whether these markers remain predictive in the era of lung-protective ventilation...
  14. pmc Therapeutic potential of mesenchymal stem cells for severe acute lung injury
    Michael A Matthay
    Department of Medicine, University of California, San Francisco, CA 94143 0624, USA
    Chest 138:965-72. 2010
    ..There is a dual focus on how to design trials for testing both safety and efficacy...
  15. pmc The acute respiratory distress syndrome: pathogenesis and treatment
    Michael A Matthay
    The Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, 94143, USA
    Annu Rev Pathol 6:147-63. 2011
    ..However, there is no effective pharmacologic therapy, although cell-based therapy and other therapies currently being tested in clinical trials may provide novel treatments for ARDS...
  16. doi request reprint Treatment of acute lung injury: clinical and experimental studies
    Michael A Matthay
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA
    Proc Am Thorac Soc 5:297-9. 2008
    ....
  17. pmc Mesenchymal stem cells for acute lung injury: preclinical evidence
    Michael A Matthay
    Department of Medicine, University of California, San Francisco, CA, USA
    Crit Care Med 38:S569-73. 2010
    ..Further preclinical studies are needed, as is planning for clinical trials for acute lung injury...
  18. pmc Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational management
    Michael A Matthay
    Department of Medicine, Cardiovascular Research and Training Institute, University of California at San Francisco, San Francisco, California 94143 0130, USA
    Am J Respir Cell Mol Biol 33:319-27. 2005
  19. ncbi request reprint Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanisms
    Xiao Su
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 175:2598-605. 2005
    ..These effects were either partly or completely neuropeptide dependent, suggesting that PAR2 can cause lung inflammation by a neurogenic mechanism...
  20. ncbi request reprint Lidocaine induces a reversible decrease in alveolar epithelial fluid clearance in rats
    Marc Laffon
    Cardiovascular Research Institute and the Department of Anesthesia, University of California, San Francisco, California 94142 0130, USA
    Anesthesiology 96:392-9. 2002
    ..The objective of this study was to assess the effect of lidocaine on alveolar fluid clearance, the primary mechanism responsible for the resolution of alveolar edema...
  21. pmc Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungs
    Raphael Briot
    University of California, San Francisco, Cardiovascular Research Institute, San Francisco, CA 94143 0624, USA
    Chest 135:269-75. 2009
    ..A second objective was to determine whether levels of a marker of endothelial injury, von Willebrand factor antigen (vWF:Ag), are associated with impaired AFC...
  22. ncbi request reprint Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injury
    James A Frank
    Cardiovascular Research Institute, University of California, San Francisco, USA
    Crit Care Med 33:181-8; discussion 254-5. 2005
    ..The primary objective of this study was to determine the effect of one type of recruitment maneuver--sustained inflation--on alveolar epithelial and lung endothelial injury in experimental acute lung injury...
  23. pmc Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injury
    Michael T Ganter
    Department of Anesthesia, University of California, San Francisco, 94110, USA
    Am J Physiol Lung Cell Mol Physiol 291:L354-61. 2006
    ..Thus SPR may protect the alveolar epithelium against oxidative stress associated with experimental ALI, and eHsp72 may serve as a marker of SPR activation in the distal air spaces of patients with ALI...
  24. pmc Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injury
    Xiao Su
    Cardiovascular Research Institute, University of California, San Francisco, California 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 297:L1-5. 2009
    ..In summary, BAL RAGE is an indicator of ALI, and it may be useful in distinguishing direct from indirect models of ALI as well as assessing the response to specific therapies...
  25. ncbi request reprint Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injury
    Polly E Parsons
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Fletcher Allen Health Care, University of Vermont, USA
    Crit Care Med 33:1-6; discussion 230-2. 2005
    ....
  26. pmc Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesis
    Richard D Fremont
    Division of Allergy, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    J Trauma 68:1121-7. 2010
    ..The aims of this study were to develop a panel of plasma biomarkers to facilitate diagnosis of trauma-induced ALI and to enhance our understanding of the pathogenesis of human ALI...
  27. pmc Recent trends in acute lung injury mortality: 1996-2005
    Sara E Erickson
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, GA, USA
    Crit Care Med 37:1574-9. 2009
    ..We sought to determine whether recent advances in the treatment of ALI and related critical illnesses have resulted in decreased mortality from ALI...
  28. ncbi request reprint Hydrostatic mechanisms may contribute to the pathogenesis of human re-expansion pulmonary edema
    Richard D Sue
    Division of Pulmonary and Critical Care Medicine, University of California, 900 Veteran Avenue, 14 154 Warren Hall, Los Angeles, CA 90024 1999, USA
    Intensive Care Med 30:1921-6. 2004
    ..A secondary objective was to determine if the alveolar epithelium was functionally intact in patients with re-expansion pulmonary edema by measuring net alveolar epithelial fluid transport in a subset of patients...
  29. ncbi request reprint Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injury
    Polly E Parsons
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Fletcher Allen Health Care, University of Vermont, Burlington, Vermont 05401, USA
    Am J Physiol Lung Cell Mol Physiol 288:L426-31. 2005
    ..Furthermore, LTVV is associated with a specific decrease in sTNFRI levels. This suggests that one beneficial effect of LTVV may be to attenuate alveolar epithelial injury...
  30. pmc Evidence against aquaporin-1-dependent CO2 permeability in lung and kidney
    Xiaohui Fang
    Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0521, USA
    J Physiol 542:63-9. 2002
    ..The results provide direct evidence against physiologically significant transport of CO2 by AQP1 in mammalian lung and kidney...
  31. ncbi request reprint Fluid transport across cultured rat alveolar epithelial cells: a novel in vitro system
    Xiaohui Fang
    Cardiovascular Research Institute, University of California, San Francisco, 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 287:L104-10. 2004
    ..In conclusion, this novel in vitro system can be used to measure net vectorial fluid transport across cultured, polarized alveolar epithelial cells...
  32. pmc CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia
    Xiao Su
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
    J Immunol 180:6947-53. 2008
    ..coli pneumonia had an improved survival rate. Taken together, deficiency of CD47 protects mice from LPS-induced acute lung injury and E. coli pneumonia. Targeting CD47 may be a novel pathway for treatment of acute lung injury...
  33. ncbi request reprint Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism
    James Frank
    Laboratory of Surgical Research, Cardiovascular Research Institute, Lung Biology Center, Departments of Anesthesia, Surgery, and Medicine, University of California, San Francisco, California 94110, USA
    J Biol Chem 278:43939-50. 2003
    ..This reduction in sodium and fluid transport is attributable in large part to a reduction in apical membrane alphaENaC expression mediated through an ERK1/2-dependent inhibition of the alphaENaC promoter activity...
  34. pmc Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndrome
    Lorraine B Ware
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 35:1821-8. 2007
    ..However, direct evidence for the contribution of abnormalities in coagulation and fibrinolysis proteins to outcomes in patients with acute lung injury/acute respiratory distress syndrome is lacking...
  35. ncbi request reprint Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure
    Kamran Atabai
    Department of Medicine, University of California San Francisco, San Francisco, CA 94143 0130, USA
    Intensive Care Med 28:705-11. 2002
    ..However, no studies have determined whether aerosolized beta-adrenergic agonists are delivered to the distal air spaces of the lung in therapeutic concentrations in patients with pulmonary edema...
  36. ncbi request reprint Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway
    Jeremie Roux
    Laboratory of Surgical Research, Cardiovascular Research Institute, Department of Anesthesia, University of California, San Francisco 94110, USA
    J Biol Chem 280:18579-89. 2005
    ....
  37. ncbi request reprint Therapeutic strategies for severe acute lung injury
    Janet V Diaz
    University of California, San Francisco, San Francisco, CA, USA
    Crit Care Med 38:1644-50. 2010
    ..Our goal is to provide a practical, evidence-based review to assist critical care physicians' care for patients with severe acute lung injury and acute respiratory distress syndrome...
  38. ncbi request reprint Bench to bedside: targeting coagulation and fibrinolysis in acute lung injury
    Lorraine B Ware
    Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Physiol Lung Cell Mol Physiol 291:L307-11. 2006
    ....
  39. pmc Role of protease activated receptor 2 in experimental acute lung injury and lung fibrosis
    Xiao Su
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Anat Rec (Hoboken) 292:580-6. 2009
    ..Thus, PAR2 does not appear to play a critical role in the pathogeneses of experimental acid-induced acute lung injury, E. coli pneumonia, and bleomycin-induced acute lung injury and pulmonary fibrosis in mice...
  40. pmc Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms
    Michael T Ganter
    Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco 94110, USA
    Circ Res 102:804-12. 2008
    ..In summary, these results demonstrate a critical role for the alphavbeta5/beta6 integrins in mediating the IL-1beta-induced ALI and indicate that these integrins could be a potentially attractive therapeutic target in ALI...
  41. pmc Pharmacotherapy of acute lung injury and the acute respiratory distress syndrome
    Magda Cepkova
    Cardiovascular Research Institute, University of California San Francisco, CA 94143 0130, USA
    J Intensive Care Med 21:119-43. 2006
    ....
  42. ncbi request reprint Pulmonary edema fluid antioxidants are depressed in acute lung injury
    Russell P Bowler
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
    Crit Care Med 31:2309-15. 2003
    ..To test the hypothesis that low concentrations of distal airspace water-soluble antioxidants are associated with acute lung injury...
  43. ncbi request reprint Pleural surface fluorescence measurement of Na+ and Cl- transport across the air space-capillary barrier
    Jinjun Jiang
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, 94143 0521, USA
    J Appl Physiol 94:343-52. 2003
    ..Our results establish a pleural surface fluorescence method to measure unidirectional Cl(-) and Na(+) flux in intact lung and provide evidence for cAMP-stimulated transcellular Cl(-) and Na(+) transport...
  44. pmc Novel role of the human alveolar epithelium in regulating intra-alveolar coagulation
    Ling Wang
    Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Am J Respir Cell Mol Biol 36:497-503. 2007
    ..Local fibrin deposition may be a fundamental mechanism for the lung to localize and confine injury, thus limiting the risk of dissemination of injury or infection to the systemic circulation...
  45. ncbi request reprint Microarray analysis indicates that pulmonary edema fluid from patients with acute lung injury mediates inflammation, mitogen gene expression, and fibroblast proliferation through bioactive interleukin-1
    Mitchell A Olman
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, The University of Alabama, Birmingham, AL 35294, USA
    Chest 121:69S-70S. 2002
  46. ncbi request reprint Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injury
    Magda Cepkova
    Department of Anesthesia, University of California, San Francisco, San Francisco, CA, USA
    Chest 132:836-42. 2007
    ....
  47. pmc Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury
    R Gisli Jenkins
    Lung Biology Center, UCSF, San Francisco, California 94158, USA
    J Clin Invest 116:1606-14. 2006
    ....
  48. ncbi request reprint Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expression
    Mitchell A Olman
    Department of Medicine, University of Alabama, Birmingham AL 35294, USA
    J Immunol 172:2668-77. 2004
    ....
  49. pmc Bench-to-bedside review: the role of the alveolar epithelium in the resolution of pulmonary edema in acute lung injury
    Rachel L Zemans
    Department of Medicine, University of California, San Francisco, California, USA
    Crit Care 8:469-77. 2004
    ..Since relevant clinical outcomes correlate with rates of edema clearance in ALI, therapies based on our understanding of the mechanisms and regulation of fluid transport may be developed...
  50. ncbi request reprint Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injury
    Daniel F McAuley
    Cardiovascular Research Institute, University of California, San Francisco, CA, USA
    Crit Care Med 32:1470-6. 2004
    ....
  51. pmc Protective mechanisms of activated protein C in severe inflammatory disorders
    Arne P Neyrinck
    University of California San Francisco, Cardiovascular Research Institute, San Francisco, CA, USA
    Br J Pharmacol 158:1034-47. 2009
    ..On the whole, these studies have not supported the use of APC in these populations and challenge the field of APC research to search for additional answers...
  52. pmc Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function
    George Su
    Lung Biology Center, Division of Pulmonary and Critical Care Medicine, Laboratory of Surgical Research, Department of Anesthesia, and Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
    Am J Respir Cell Mol Biol 36:377-86. 2007
    ..These results identify integrin alphavbeta5 as a central regulator of increased pulmonary vascular permeability and a potentially attractive therapeutic target in ALI...
  53. pmc Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injury
    Joyce S Lee
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143, USA
    Anat Rec (Hoboken) 294:165-72. 2011
    ..This model should be useful to investigators studying ALI who want to simulate the clinical setting in which more than one insult often leads to greater clinical lung injury...
  54. pmc Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injury
    Carolyn S Calfee
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA, 94143 0111, USA
    Intensive Care Med 35:248-57. 2009
    ....
  55. pmc Regulated gene expression in cultured type II cells of adult human lung
    Philip L Ballard
    Department of Pediatrics, University of California San Francisco, San Francisco, USA
    Am J Physiol Lung Cell Mol Physiol 299:L36-50. 2010
    ..Our results further define the adult human type II cell molecular phenotype and demonstrate that a subset of genes remains hormone responsive in cultured adult cells...
  56. pmc Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injury
    Mark R Looney
    Department of Medicine, UCSF, San Francisco, California 94143 0130, USA
    J Clin Invest 119:3450-61. 2009
    ..Furthermore, our data offer an explanation for the increased incidence of TRALI in patients with immune priming conditions, and we suggest what we believe to be a novel therapeutic approach...
  57. pmc Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injury
    Kathleen D Liu
    Division of Nephrology, University of California, San Francisco, CA, USA
    Crit Care Med 35:2755-61. 2007
    ..To identify biological and clinical predictors of acute kidney injury in subjects with acute lung injury...
  58. pmc Single-nucleotide polymorphisms in the β-adrenergic receptor genes are associated with lung allograft utilization
    Anil Sapru
    Department of Pediatrics, Cardiovascular Research Institute, University of California San Francisco, San Franscisco, California 94143, USA
    J Heart Lung Transplant 30:211-7. 2011
    ..We hypothesized that SNPs in βAR genes would be associated with rates of utilization of donor lung allografts offered for transplantation...
  59. pmc Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury
    Binh An Diep
    Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, CA 94110, USA
    Proc Natl Acad Sci U S A 107:5587-92. 2010
    ..These findings provide insights into the mechanism of PVL-induced lung injury and inflammation and demonstrate the utility of the rabbit for studying PVL-mediated pathogenesis...
  60. ncbi request reprint Alveolar epithelium: role in lung fluid balance and acute lung injury
    Michael A Matthay
    Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 0624, USA
    Proc Am Thorac Soc 2:206-13. 2005
    ..Clinical trials are needed to test this potential therapeutic strategy in patients with acute lung injury...
  61. ncbi request reprint Acute effects of tidal volume strategy on hemodynamics, fluid balance, and sedation in acute lung injury
    Ivan W Cheng
    Cardiovascular Research Institute, University of California, San Francisco, USA
    Crit Care Med 33:63-70; discussion 239-40. 2005
    ....
  62. ncbi request reprint Recent advances in mechanical ventilation
    Carolyn S Calfee
    Cardiovascular Research Institute, San Francisco, California, USA
    Am J Med 118:584-91. 2005
    ..This article critically reviews the most important recent advances in mechanical ventilation and suggests future directions for further research in the field...
  63. ncbi request reprint Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cells
    Xiaohui Fang
    Cardiovascular Research Inst, Department of Medicine Physiology, Univ of California, San Francisco, CA 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 290:L242-9. 2006
    ..We conclude that CFTR is expressed in cultured human AT II cells and may contribute to cAMP-regulated apical-basolateral fluid transport...
  64. ncbi request reprint High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantation
    Lorraine B Ware
    Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    J Heart Lung Transplant 24:1650-6. 2005
    ..The secondary objective was to better define the spectrum of histologic abnormalities in the same group of lungs...
  65. ncbi request reprint Proteomics: current techniques and potential applications to lung disease
    Jan Hirsch
    Cardiovascular Research Institute, University of California, San Francisco, 505 Parnassus Ave HSW 825, San Francisco, CA 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 287:L1-23. 2004
    ..This article provides a brief review of the most promising proteomics methods and some of their applications to pulmonary research...
  66. ncbi request reprint Protective effect of endogenous beta-adrenergic tone on lung fluid balance in acute bacterial pneumonia in mice
    Xiao Su
    Cardiovascular Research Institute, Univ of California, San Francisco, CA 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 290:L769-L776. 2006
    ..coli pneumonia in mice by two mechanisms: 1) reducing lung vascular injury and 2) upregulating the resolution of alveolar edema...
  67. ncbi request reprint High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearance
    James A Frank
    Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 284:L791-8. 2003
    ..Because air space edema fluid inactivates surfactant and reduces ventilated lung volume, the reduction of cAMP-dependent AFC by reactive nitrogen species may be an important mechanism of clinical ventilator-associated lung injury...
  68. ncbi request reprint Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized mice
    Xiao Su
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Exp Lung Res 30:479-93. 2004
    ..This method should be valuable for experimental lung studies in mice...
  69. ncbi request reprint Invited review: Active fluid clearance from the distal air spaces of the lung
    Michael A Matthay
    University of California, San Francisco, California 94143 0624, USA
    J Appl Physiol (1985) 93:1533-41. 2002
    ..The new insights into the role of the distal lung epithelium in actively regulating lung fluid balance has important implications for the resolution of clinical pulmonary edema...
  70. pmc Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and rats
    Xiao Su
    Cardiovascular Research Institute, University of California San Francisco, HSW 825, 505 Parnassus Ave, San Francisco, CA 94143 0130, USA
    Am J Respir Cell Mol Biol 37:186-92. 2007
    ..These results indicate that activation of alpha7 nAChR may provide a new therapeutic pathway for the treatment of acute lung injury...
  71. ncbi request reprint Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathways
    Anil Sapru
    Pediatric Critical Care Medicine, University of California, 505 Parnassus Avenue, Moffitt 680 B, San Francisco, CA 94143 0106, USA
    Intensive Care Med 32:1293-303. 2006
    ....
  72. ncbi request reprint Ventilator-induced lung injury: in vivo and in vitro mechanisms
    Michael A Matthay
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 283:L678-82. 2002
    ....
  73. ncbi request reprint Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in rats
    Jan Hirsch
    Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143 0446, USA
    Mol Cell Proteomics 5:979-86. 2006
    ..The ability to simultaneously monitor several pathways involved in reperfusion stress may result in important mechanistic insight and possibly new treatment options...
  74. pmc Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanism
    Jeremie Roux
    Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco, California 94110, USA
    J Biol Chem 285:4278-90. 2010
    ....
  75. pmc Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndrome
    Kurt H Albertine
    Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, University of Utah, Salt Lake City 84132, USA
    Am J Pathol 161:1783-96. 2002
    ....
  76. ncbi request reprint Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome
    Akitoshi Ishizaka
    Department of Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582 Japan
    Am J Physiol Lung Cell Mol Physiol 286:L1088-94. 2004
    ....
  77. ncbi request reprint Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilation
    Heidi R Flori
    Department of Pediatric Critical Care, Children s Hospital and Research Center, Oakland, Oakland, CA 94609, USA
    Pediatr Crit Care Med 4:315-21. 2003
    ....
  78. ncbi request reprint Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alpha
    Nadia Elia
    Division of Anesthesiological Investigations, University Medical Center, Geneva, Switzerland
    Am J Respir Crit Care Med 168:1043-50. 2003
    ..There was also a significant reduction in lung water. These results indicate that the receptor-independent lectin-like domain of mTNF-alpha has a potential physiological role in the resolution of alveolar edema in rats and mice...
  79. ncbi request reprint Protein C and thrombomodulin in human acute lung injury
    Lorraine B Ware
    Vanderbilt Univ School of Medicine, Nashville, TN 37232 2650, USA
    Am J Physiol Lung Cell Mol Physiol 285:L514-21. 2003
    ..In summary, the protein C system is markedly disrupted in patients with ALI/ARDS from both septic and nonseptic causes. The protein C system may be a potential therapeutic target in patients with ALI/ARDS...
  80. ncbi request reprint Distal air space epithelial fluid clearance in near-term rat fetuses is fast and requires endogenous catecholamines
    Hans G Folkesson
    Department of Physiology, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272 0095, USA
    Am J Physiol Lung Cell Mol Physiol 282:L508-15. 2002
    ..In conclusion, these studies demonstrate that 1) rapid rates of net alveolar fluid clearance occur late in gestation in the rat and 2) this clearance is driven by elevations of endogenous epinephrine...
  81. ncbi request reprint Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injury
    Priya Prabhakaran
    Department of Pediatrics, University of Alabama, Birmingham, Alabama 35294, USA
    Am J Physiol Lung Cell Mol Physiol 285:L20-8. 2003
    ..The data indicate that fibrin turnover in early ALI is a consequence of a rapid fibrinogen influx and fractional fibrinolytic inhibition...
  82. ncbi request reprint Selected contribution: mechanisms that may stimulate the resolution of alveolar edema in the transplanted human lung
    Lorraine B Ware
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
    J Appl Physiol (1985) 93:1869-74. 2002
    ..Aerosolized beta(2)-adrenergic agonists may have therapeutic value for hastening the resolution of alveolar edema during the management of donors before resection of lungs for transplantation or in the posttransplant setting...
  83. ncbi request reprint Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells
    Carole Planes
    Department of Physiology, INSERM U426, Universite Paris 7, 75018 Paris, France
    J Biol Chem 277:47318-24. 2002
    ....
  84. ncbi request reprint Time-dependent effect of pneumonectomy on alveolar epithelial fluid clearance in rat lungs
    Tsutomu Sakuma
    Department of Thoracic Surgery, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    J Thorac Cardiovasc Surg 124:668-74. 2002
    ..Because pneumonectomy initiates compensatory growth of the remaining lung, we determined the time-dependent effects of pneumonectomy on alveolar fluid clearance capacity...
  85. ncbi request reprint Activity of pulmonary edema fluid interleukin-8 bound to alpha(2)-macroglobulin in patients with acute lung injury
    Anna K Kurdowska
    Department of Biochemistry, University of Texas Health Center, Tyler, Texas 75708, USA
    Am J Physiol Lung Cell Mol Physiol 282:L1092-8. 2002
    ..Furthermore, IL-8 bound to alpha(2)-M retained its biological activity, and this fraction of IL-8 was protected from proteolytic degradation. Thus complex formation may modulate the acute inflammatory process in the lung...
  86. ncbi request reprint Effect of continuous hemofiltration on hemodynamics, lung inflammation and pulmonary edema in a canine model of acute lung injury
    Xiao Su
    Research Institute of Respiratory Diseases, Zhongshan Hospital, Fudan University, Shanghai, P R China
    Intensive Care Med 29:2034-42. 2003
    ..This study examined whether continuous hemofiltration favorably affects cardiopulmonary variables, lung inflammation, and lung fluid balance in a canine model of oleic acid induced acute lung injury...
  87. ncbi request reprint Cytokine-mediated inflammation in acute lung injury
    Richard B Goodman
    Medical Research Service, Department of Veterans Affairs, VA Puget Sound Health Care System, VA Puget Sound Medical Center, Division of Pulmonary and Critical Care, University of Washington School of Medicine, Seattle, WA 98108, USA
    Cytokine Growth Factor Rev 14:523-35. 2003
    ..Further research is needed to establish the contribution of cytokines to both the pathogenesis and resolution of ALI...
  88. pmc Postobstructive pulmonary edema: a case for hydrostatic mechanisms
    Richard D Fremont
    Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, T1218 MCN, 1161 Twenty First Ave S, Nashville, TN 37232 2650, USA
    Chest 131:1742-6. 2007
    ..The goal of the current study was to investigate the mechanisms of pulmonary edema formation in patients with postobstructive pulmonary edema by serial sampling of undiluted pulmonary edema fluid...
  89. pmc Alveolar epithelial ion and fluid transport: recent progress
    Hans G Folkesson
    Department of Physiology and Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown, USA
    Am J Respir Cell Mol Biol 35:10-9. 2006
  90. ncbi request reprint Integrating acute lung injury and regulation of alveolar fluid clearance
    David M Guidot
    Emory University School of Medicine, Atlanta, Georgia, USA
    Am J Physiol Lung Cell Mol Physiol 291:L301-6. 2006
    ....
  91. pmc Alveolar edema fluid clearance and acute lung injury
    Yves Berthiaume
    Département de médecine et Centre de recherche du Centre Hospitalier de l Université de Montréal, Universite de Montreal, Montreal, Quebec, Canada
    Respir Physiol Neurobiol 159:350-9. 2007
    ....
  92. ncbi request reprint Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in mice
    Vladimir B Serikov
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Anat Rec (Hoboken) 290:1033-45. 2007
    ..These data confirm that bone marrow-derived cultured mesenchymal cells can participate in the recovery of the injured airway epithelium after naphthalene-induced injury with minimal long-term engraftment...
  93. pmc Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine
    Tsutomu Sakuma
    Thoracic Surgery, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Crit Care Med 34:676-81. 2006
    ....
  94. pmc Bone marrow-derived cells participate in stromal remodeling of the lung following acute bacterial pneumonia in mice
    Vladimir B Serikov
    Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
    Lung 186:179-90. 2008
    ....
  95. pmc Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injury
    Tokujiro Uchida
    Department of Anesthesiology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Am J Respir Crit Care Med 173:1008-15. 2006
    ..Receptor for advanced glycation end-products (RAGE) is one of the alveolar type I cell-associated proteins in the lung...
  96. ncbi request reprint Significance of von Willebrand factor in septic and nonseptic patients with acute lung injury
    Lorraine B Ware
    Division of Allergy, Pulmonary and Critical Care Medicine, T1217 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
    Am J Respir Crit Care Med 170:766-72. 2004
    ..To improve outcomes further, new treatment strategies targeted at the endothelium should be investigated...
  97. ncbi request reprint Malnutrition impairs alveolar fluid clearance in rat lungs
    Tsutomu Sakuma
    Department of Thoracic Surgery, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Am J Physiol Lung Cell Mol Physiol 286:L1268-74. 2004
    ....
  98. ncbi request reprint Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injury
    Russell P Bowler
    National Jewish Medical and Research Center, K736a, 1400 Jackson St, Denver, CO 80206, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1095-104. 2004
    ..Nearly all ALI patients also had protein spots that indicate truncation or other posttranslational modifications. Several of these novel changes could serve as new biomarkers of lung injury...
  99. ncbi request reprint Proinflammatory activity of anti-IL-8 autoantibody:IL-8 complexes in alveolar edema fluid from patients with acute lung injury
    Agnieszka Krupa
    Department of Biochemistry, University of Texas Health Center, 11937 US Highway 271, Tyler, TX 75708 3154, USA
    Am J Physiol Lung Cell Mol Physiol 286:L1105-13. 2004
    ..e., ERK and p38, important components of the FcgammaRIIa signaling cascade. Anti-IL-8:IL-8 complexes may therefore be involved in the pathogenesis of lung inflammation in clinical acute lung injury...
  100. pmc Transgenic overexpression of granulocyte macrophage-colony stimulating factor in the lung prevents hyperoxic lung injury
    Robert Paine
    Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan 48105, USA
    Am J Pathol 163:2397-406. 2003
    ....
  101. ncbi request reprint Treatment of acute lung injury: historical perspective and potential future therapies
    Joseph E Levitt
    Division of Pulmonary and Critical Care, Stanford University, Stanford, California 94305, USA
    Semin Respir Crit Care Med 27:426-37. 2006
    ..This article focuses on clinical treatments for ALI that have been tested in phase II and III clinical trials as well as a discussion of potential future therapies...

Research Grants29

  1. RESOLUTION OF CLINICAL LUNG INJURY
    Michael Matthay; Fiscal Year: 2001
    ....
  2. MECHANISMS OF ALVEOLAR EPITHELIAL FLUID CLEARANCE
    Michael Matthay; Fiscal Year: 2002
    ..The information provided from these experimental studies should provide new strategies for accelerating the resolution of hydrostatic or increased permeability pulmonary edema in humans. ..
  3. RESOLUTION OF CLINICAL LUNG INJURY
    Michael Matthay; Fiscal Year: 2002
    ....
  4. MECHANISMS OF ALVEOLAR EPITHELIAL FLUID CLEARANCE
    Michael Matthay; Fiscal Year: 2003
    ..Overall, these studies will provide important new insights into the basic mechanisms that regulate epithelial fluid transport and lung fluid balance in the normal and the injured lung. ..
  5. RESOLUTION OF CLINICAL LUNG INJURY
    Michael Matthay; Fiscal Year: 2003
    ....
  6. MECHANISMS OF ALVEOLAR EPITHELIAL FLUID CLEARANCE
    Michael Matthay; Fiscal Year: 2004
    ..Overall, these studies will provide important new insights into the basic mechanisms that regulate epithelial fluid transport and lung fluid balance in the normal and the injured lung. ..
  7. RESOLUTION OF CLINICAL LUNG INJURY
    Michael Matthay; Fiscal Year: 2004
    ....
  8. MECHANISMS OF ALVEOLAR EPITHELIAL FLUID CLEARANCE
    Michael Matthay; Fiscal Year: 2005
    ..Overall, these studies will provide important new insights into the basic mechanisms that regulate epithelial fluid transport and lung fluid balance in the normal and the injured lung. ..
  9. RESOLUTION OF CLINICAL LUNG INJURY
    Michael Matthay; Fiscal Year: 2005
    ....
  10. MECHANISMS OF ALVEOLAR EPITHELIAL FLUID CLEARANCE
    Michael Matthay; Fiscal Year: 2007
    ..Overall, these studies will provide important new insights into the basic mechanisms that regulate epithelial fluid transport and lung fluid balance in the normal and the injured lung. ..
  11. MECHANISMS OF ALVEOLAR EPITHELIAL FLUID CLEARANCE
    Michael Matthay; Fiscal Year: 2000
    ..The information provided from these experimental studies should provide new strategies for accelerating the resolution of hydrostatic or increased permeability pulmonary edema in humans. ..
  12. Lung Fluid Balance and Mesenchymal Stem Cells
    Michael Matthay; Fiscal Year: 2009
    ....
  13. MECHANISMS OF ALVEOLAR EPITHELIAL FLUID CLEARANCE
    Michael Matthay; Fiscal Year: 1999
    ..The information provided from these experimental studies should provide new strategies for accelerating the resolution of hydrostatic or increased permeability pulmonary edema in humans. ..
  14. ALVEOLAR EPITHELIAL BARRIER IN CLINICAL LUNG INJURY
    Michael Matthay; Fiscal Year: 1999
    ....
  15. MECHANISMS OF ALVEOLAR EPITHELIAL FLUID CLEARANCE
    Michael Matthay; Fiscal Year: 2006
    ..Overall, these studies will provide important new insights into the basic mechanisms that regulate epithelial fluid transport and lung fluid balance in the normal and the injured lung. ..
  16. MECHANISMS OF ALVEOLAR EPITHELIAL FLUID CLEARANCE
    Michael Matthay; Fiscal Year: 2001
    ..The information provided from these experimental studies should provide new strategies for accelerating the resolution of hydrostatic or increased permeability pulmonary edema in humans. ..
  17. ALVEOLAR EPITHELIAL BARRIER IN CLINICAL LUNG INJURY
    Michael Matthay; Fiscal Year: 2000
    ....
  18. Lung Fluid Balance and Mesenchymal Stem Cells
    Michael A Matthay; Fiscal Year: 2010
    ....