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Genomes and Genes | Michael MatthaySummaryAffiliation: University of California Country: USA Publications
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Publications
Randomized clinical trial of activated protein C for the treatment of acute lung injuryKathleen D Liu
Division of Nephrology and Critical Care Medicine, Department of Medicine, Box 0532, University of California, San Francisco, San Francisco, CA 94143 0532, USA
Am J Respir Crit Care Med 178:618-23. 2008..Plasma protein C levels are decreased in patients with acute lung injury and are associated with higher mortality and fewer ventilator-free days...- The acute respiratory distress syndromeMichael A Matthay
Cardiovascular Research Institute and Departments of Medicine and Anesthesia, UCSF, San Francisco, CA, USA
J Clin Invest 122:2731-40. 2012..Improved survival has been achieved with the use of lung-protective ventilation. Future progress will depend on developing novel therapeutics that can facilitate and enhance lung repair... - Human mesenchymal stem cells reduce mortality and bacteremia in gram-negative sepsis in mice in part by enhancing the phagocytic activity of blood monocytesAnna Krasnodembskaya
Cardiovascular Research Institute and Department of Anesthesiology, University of California San Francisco, 505 Parnassus Ave, CA 94143, USA
Am J Physiol Lung Cell Mol Physiol 302:L1003-13. 2012..Thus intravenous MSC increased survival from gram-negative peritoneal sepsis, in part by a monocyte-dependent increase in bacterial phagocytosis... - Prognostic value of pulmonary dead space in patients with the acute respiratory distress syndromeMichael A Matthay
Department of Medicine and Cardiovascular Research Institute at University of California, San Francisco, 505 Parnassus Avenue, M 917, San Francisco, CA 94143 0624, USA
Crit Care 15:185. 2011.... - Vascular pedicle width in acute lung injury: correlation with intravascular pressures and ability to discriminate fluid statusTodd W Rice
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, T 1218 MCN Nashville, TN 37221, USA
Crit Care 15:R86. 2011..The VPW was studied in ALI patients to determine the correlation between VPW and intravascular pressure measurements and whether VPW could predict fluid status... - Assessing the quantity of pulmonary edema in critically ill childrenDaniel F McAuley
Regional Intensive Care Unit, Royal Victoria Hospital, Grosvenor Road, Belfast BT12 6BA, N Ireland
Crit Care 14:189. 2010..The present commentary briefly reviews the potential role and limitations of extravascular lung water measurement in critically ill children... - Inhaled activated protein C: a novel therapy for acute lung injury?Kathleen D Liu
Division of Nephrology and Critical Care Medicine, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143 0624, USA
Crit Care 13:150. 2009..Future studies are needed to determine plasma and airspace APC levels when administered by the inhaled route, and to determine if inhaled APC has a similar effect in other models of ALI... - Protein C as a surrogate end-point for clinical trials of sepsisKathleen D Liu
Divisions of Nephrology and Critical Care Medicine, Department of Medicine, University of California, 521 Parnassus Ave, C443, San Francisco, CA 94143, USA
Crit Care 12:139. 2008..Only protein C had acceptable performance characteristics as a type 2 biomarker, or surrogate end-point. The utility of protein C as a surrogate end-point for studies of severe sepsis must be validated in future prospective studies... - Biological markers of lung injury before and after the institution of positive pressure ventilation in patients with acute lung injuryMagda Cepkova
The Cardiovascular Research Institute and the Departments of Medicine and Anesthesia, University of California, San Francisco, 505 Parnassus Avenue, M917, San Francisco, CA 94143 0624, USA
Crit Care 10:R126. 2006.... - Biomarkers of inflammation, coagulation and fibrinolysis predict mortality in acute lung injuryDana McClintock
Cardiovascular Research Institute, 505 Parnassus Avenue, University of California, San Francisco, San Francisco, CA 94143, USA
Crit Care 12:R41. 2008..We measured plasma markers of inflammation, coagulation and fibrinolysis simultaneously to assess whether these markers remain predictive in the era of lung-protective ventilation... - Therapeutic potential of mesenchymal stem cells for severe acute lung injuryMichael A Matthay
Department of Medicine, University of California, San Francisco, CA 94143 0624, USA
Chest 138:965-72. 2010..There is a dual focus on how to design trials for testing both safety and efficacy... - The acute respiratory distress syndrome: pathogenesis and treatmentMichael A Matthay
The Cardiovascular Research Institute, Department of Medicine, University of California, San Francisco, 94143, USA
Annu Rev Pathol 6:147-63. 2011..However, there is no effective pharmacologic therapy, although cell-based therapy and other therapies currently being tested in clinical trials may provide novel treatments for ARDS... - Acute lung injury and the acute respiratory distress syndrome: four decades of inquiry into pathogenesis and rational managementMichael A Matthay
Department of Medicine, Cardiovascular Research and Training Institute, University of California at San Francisco, San Francisco, California 94143-0130, USA
Am J Respir Cell Mol Biol 33:319-27. 2005 - Mesenchymal stem cells for acute lung injury: preclinical evidenceMichael A Matthay
Department of Medicine, University of California, San Francisco, CA, USA
Crit Care Med 38:S569-73. 2010..Further preclinical studies are needed, as is planning for clinical trials for acute lung injury... 
Treatment of acute lung injury: clinical and experimental studiesMichael A Matthay
Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California, USA
Proc Am Thorac Soc 5:297-9. 2008....
Protease-activated receptor-2 activation induces acute lung inflammation by neuropeptide-dependent mechanismsXiao Su
Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 175:2598-605. 2005..These effects were either partly or completely neuropeptide dependent, suggesting that PAR2 can cause lung inflammation by a neurogenic mechanism...- Lidocaine induces a reversible decrease in alveolar epithelial fluid clearance in ratsMarc Laffon
Cardiovascular Research Institute and the Department of Anesthesia, University of California, San Francisco, California 94142-0130, USA
Anesthesiology 96:392-9. 2002..Importantly, the effect of lidocaine was completely reversible with beta2-adrenergic therapy... - Elevated levels of the receptor for advanced glycation end products, a marker of alveolar epithelial type I cell injury, predict impaired alveolar fluid clearance in isolated perfused human lungsRaphael Briot
University of California, San Francisco, Cardiovascular Research Institute, San Francisco, CA 94143 0624, USA
Chest 135:269-75. 2009..A second objective was to determine whether levels of a marker of endothelial injury, von Willebrand factor antigen (vWF:Ag), are associated with impaired AFC... - Lower tidal volume ventilation and plasma cytokine markers of inflammation in patients with acute lung injuryPolly E Parsons
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Fletcher Allen Health Care, University of Vermont, USA
Crit Care Med 33:1-6; discussion 230-2. 2005..Low tidal volume ventilation is associated with a more rapid attenuation of the inflammatory response... - Extracellular heat shock protein 72 is a marker of the stress protein response in acute lung injuryMichael T Ganter
Department of Anesthesia, University of California, San Francisco, 94110, USA
Am J Physiol Lung Cell Mol Physiol 291:L354-61. 2006..Thus SPR may protect the alveolar epithelium against oxidative stress associated with experimental ALI, and eHsp72 may serve as a marker of SPR activation in the distal air spaces of patients with ALI... - Receptor for advanced glycation end-products (RAGE) is an indicator of direct lung injury in models of experimental lung injuryXiao Su
Cardiovascular Research Institute, University of California, San Francisco, California 94143 0130, USA
Am J Physiol Lung Cell Mol Physiol 297:L1-5. 2009..In summary, BAL RAGE is an indicator of ALI, and it may be useful in distinguishing direct from indirect models of ALI as well as assessing the response to specific therapies... - Differential effects of sustained inflation recruitment maneuvers on alveolar epithelial and lung endothelial injuryJames A Frank
Cardiovascular Research Institute, University of California, San Francisco, USA
Crit Care Med 33:181-8; discussion 254-5. 2005..Additional clinical studies will be needed to assess the net impact of recruitment maneuvers in patients with acute lung injury... - Acute lung injury in patients with traumatic injuries: utility of a panel of biomarkers for diagnosis and pathogenesisRichard D Fremont
Division of Allergy, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
J Trauma 68:1121-7. 2010..The aims of this study were to develop a panel of plasma biomarkers to facilitate diagnosis of trauma-induced ALI and to enhance our understanding of the pathogenesis of human ALI... - Fluid transport across cultured rat alveolar epithelial cells: a novel in vitro systemXiaohui Fang
Cardiovascular Research Institute, University of California, San Francisco, 94143-0130, USA
Am J Physiol Lung Cell Mol Physiol 287:L104-10. 2004..In conclusion, this novel in vitro system can be used to measure net vectorial fluid transport across cultured, polarized alveolar epithelial cells... - Hydrostatic mechanisms may contribute to the pathogenesis of human re-expansion pulmonary edemaRichard D Sue
Division of Pulmonary and Critical Care Medicine, University of California, 900 Veteran Avenue, 14-154 Warren Hall, Los Angeles, CA 90024-1999, USA
Intensive Care Med 30:1921-6. 2004..8+/-8.0%/h) was intact in the subset of three patients in whom it was measured. CONCLUSIONS: This study provides the first direct evidence that hydrostatic forces may contribute to the development of re-expansion pulmonary edema... - Pathogenetic and prognostic significance of altered coagulation and fibrinolysis in acute lung injury/acute respiratory distress syndromeLorraine B Ware
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Crit Care Med 35:1821-8. 2007..However, direct evidence for the contribution of abnormalities in coagulation and fibrinolysis proteins to outcomes in patients with acute lung injury/acute respiratory distress syndrome is lacking... - Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanismJames Frank
Laboratory of Surgical Research, Cardiovascular Research Institute, Lung Biology Center, Departments of Anesthesia, Surgery, and Medicine, University of California, San Francisco, California 94110, USA
J Biol Chem 278:43939-50. 2003..This reduction in sodium and fluid transport is attributable in large part to a reduction in apical membrane alphaENaC expression mediated through an ERK1/2-dependent inhibition of the alphaENaC promoter activity... - CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumoniaXiao Su
Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA
J Immunol 180:6947-53. 2008..coli pneumonia had an improved survival rate. Taken together, deficiency of CD47 protects mice from LPS-induced acute lung injury and E. coli pneumonia. Targeting CD47 may be a novel pathway for treatment of acute lung injury... - Evidence against aquaporin-1-dependent CO2 permeability in lung and kidneyXiaohui Fang
Departments of Medicine and Physiology, Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0521, USA
J Physiol 542:63-9. 2002..The results provide direct evidence against physiologically significant transport of CO2 by AQP1 in mammalian lung and kidney... - Recent trends in acute lung injury mortality: 1996-2005Sara E Erickson
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, GA, USA
Crit Care Med 37:1574-9. 2009..We sought to determine whether recent advances in the treatment of ALI and related critical illnesses have resulted in decreased mortality from ALI... - Elevated plasma levels of soluble TNF receptors are associated with morbidity and mortality in patients with acute lung injuryPolly E Parsons
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Fletcher Allen Health Care, University of Vermont, Burlington, Vermont 05401, USA
Am J Physiol Lung Cell Mol Physiol 288:L426-31. 2005..Furthermore, LTVV is associated with a specific decrease in sTNFRI levels. This suggests that one beneficial effect of LTVV may be to attenuate alveolar epithelial injury... - Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathwayJeremie Roux
Laboratory of Surgical Research, Cardiovascular Research Institute, Department of Anesthesia, University of California, San Francisco 94110, USA
J Biol Chem 280:18579-89. 2005.... - Role of protease activated receptor 2 in experimental acute lung injury and lung fibrosisXiao Su
Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
Anat Rec (Hoboken) 292:580-6. 2009..Thus, PAR2 does not appear to play a critical role in the pathogeneses of experimental acid-induced acute lung injury, E. coli pneumonia, and bleomycin-induced acute lung injury and pulmonary fibrosis in mice... - Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failureKamran Atabai
Department of Medicine, University of California San Francisco, San Francisco, CA 94143-0130, USA
Intensive Care Med 28:705-11. 2002.... - Bench to bedside: targeting coagulation and fibrinolysis in acute lung injuryLorraine B Ware
Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Am J Physiol Lung Cell Mol Physiol 291:L307-11. 2006.... - Therapeutic strategies for severe acute lung injuryJanet V Diaz
University of California, San Francisco, San Francisco, CA, USA
Crit Care Med 38:1644-50. 2010..Our goal is to provide a practical, evidence-based review to assist critical care physicians' care for patients with severe acute lung injury and acute respiratory distress syndrome... - Novel role of the human alveolar epithelium in regulating intra-alveolar coagulationLing Wang
Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
Am J Respir Cell Mol Biol 36:497-503. 2007..Local fibrin deposition may be a fundamental mechanism for the lung to localize and confine injury, thus limiting the risk of dissemination of injury or infection to the systemic circulation... - Pleural surface fluorescence measurement of Na+ and Cl- transport across the air space-capillary barrierJinjun Jiang
Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, 94143 - 0521, USA
J Appl Physiol 94:343-52. 2003..Our results establish a pleural surface fluorescence method to measure unidirectional Cl(-) and Na(+) flux in intact lung and provide evidence for cAMP-stimulated transcellular Cl(-) and Na(+) transport... - Microarray analysis indicates that pulmonary edema fluid from patients with acute lung injury mediates inflammation, mitogen gene expression, and fibroblast proliferation through bioactive interleukin-1Mitchell A Olman
Department of Medicine, Division of Pulmonary and Critical Care Medicine, The University of Alabama, Birmingham, AL 35294, USA
Chest 121:69S-70S. 2002 - Pulmonary edema fluid antioxidants are depressed in acute lung injuryRussell P Bowler
Department of Medicine, National Jewish Medical and Research Center, Denver, CO, USA
Crit Care Med 31:2309-15. 2003..In acute lung injury, the distal airspace antioxidants ascorbate, urate, and glutathione may play a role in attenuating lung injury... - Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanismsMichael T Ganter
Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco 94110, USA
Circ Res 102:804-12. 2008..In summary, these results demonstrate a critical role for the alphavbeta5/beta6 integrins in mediating the IL-1beta-induced ALI and indicate that these integrins could be a potentially attractive therapeutic target in ALI... - Pharmacotherapy of acute lung injury and the acute respiratory distress syndromeMagda Cepkova
Cardiovascular Research Institute, University of California San Francisco, CA 94143 0130, USA
J Intensive Care Med 21:119-43. 2006.... - Pulmonary edema fluid from patients with early lung injury stimulates fibroblast proliferation through IL-1 beta-induced IL-6 expressionMitchell A Olman
Department of Medicine, University of Alabama, Birmingham AL 35294, USA
J Immunol 172:2668-77. 2004.... - Clinically relevant concentrations of beta2-adrenergic agonists stimulate maximal cyclic adenosine monophosphate-dependent airspace fluid clearance and decrease pulmonary edema in experimental acid-induced lung injuryDaniel F McAuley
Cardiovascular Research Institute, University of California, San Francisco, CA, USA
Crit Care Med 32:1470-6. 2004..Clinical studies are required to determine whether beta2-adrenergic agonists improve outcome in patients with acute lung injury... - Bench-to-bedside review: the role of the alveolar epithelium in the resolution of pulmonary edema in acute lung injuryRachel L Zemans
Department of Medicine, University of California, San Francisco, California, USA
Crit Care 8:469-77. 2004..Since relevant clinical outcomes correlate with rates of edema clearance in ALI, therapies based on our understanding of the mechanisms and regulation of fluid transport may be developed... - Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injuryR Gisli Jenkins
Lung Biology Center, UCSF, San Francisco, California 94158, USA
J Clin Invest 116:1606-14. 2006.... - Pulmonary dead space fraction and pulmonary artery systolic pressure as early predictors of clinical outcome in acute lung injuryMagda Cepkova
Department of Anesthesia, University of California, San Francisco, San Francisco, CA, USA
Chest 132:836-42. 2007.... - Activation of the alpha7 nAChR reduces acid-induced acute lung injury in mice and ratsXiao Su
Cardiovascular Research Institute, University of California San Francisco, HSW 825, 505 Parnassus Ave, San Francisco, CA 94143 0130, USA
Am J Respir Cell Mol Biol 37:186-92. 2007..These results indicate that activation of alpha7 nAChR may provide a new therapeutic pathway for the treatment of acute lung injury... - Acute lung injury and the coagulation pathway: Potential role of gene polymorphisms in the protein C and fibrinolytic pathwaysAnil Sapru
Pediatric Critical Care Medicine, University of California, 505 Parnassus Avenue, Moffitt 680 B, San Francisco, CA 94143 0106, USA
Intensive Care Med 32:1293-303. 2006.... - Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injuryBinh An Diep
Division of Infectious Diseases, Department of Medicine, University of California, San Francisco, CA 94110, USA
Proc Natl Acad Sci U S A 107:5587-92. 2010..These findings provide insights into the mechanism of PVL-induced lung injury and inflammation and demonstrate the utility of the rabbit for studying PVL-mediated pathogenesis... - Predictive and pathogenetic value of plasma biomarkers for acute kidney injury in patients with acute lung injuryKathleen D Liu
Division of Nephrology, University of California, San Francisco, CA, USA
Crit Care Med 35:2755-61. 2007..To identify biological and clinical predictors of acute kidney injury in subjects with acute lung injury... - Soluble intercellular adhesion molecule-1 and clinical outcomes in patients with acute lung injuryCarolyn S Calfee
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, 505 Parnassus Avenue, San Francisco, CA, 94143 0111, USA
Intensive Care Med 35:248-57. 2009.... - Platelet depletion and aspirin treatment protect mice in a two-event model of transfusion-related acute lung injuryMark R Looney
Department of Medicine, UCSF, San Francisco, California 94143 0130, USA
J Clin Invest 119:3450-61. 2009..Furthermore, our data offer an explanation for the increased incidence of TRALI in patients with immune priming conditions, and we suggest what we believe to be a novel therapeutic approach... - Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier functionGeorge Su
Lung Biology Center, Division of Pulmonary and Critical Care Medicine, Laboratory of Surgical Research, Department of Anesthesia, and Cardiovascular Research Institute, University of California, San Francisco, California 94158, USA
Am J Respir Cell Mol Biol 36:377-86. 2007..These results identify integrin alphavbeta5 as a central regulator of increased pulmonary vascular permeability and a potentially attractive therapeutic target in ALI... - Ventilator-induced lung injury: in vivo and in vitro mechanismsMichael A Matthay
Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
Am J Physiol Lung Cell Mol Physiol 283:L678-82. 2002.... - Regulated gene expression in cultured type II cells of adult human lungPhilip L Ballard
Department of Pediatrics, University of California San Francisco, San Francisco, USA
Am J Physiol Lung Cell Mol Physiol 299:L36-50. 2010..Our results further define the adult human type II cell molecular phenotype and demonstrate that a subset of genes remains hormone responsive in cultured adult cells... - Proteomics: current techniques and potential applications to lung diseaseJan Hirsch
Cardiovascular Research Institute, University of California, San Francisco, 505 Parnassus Ave HSW 825, San Francisco, CA 94143 0130, USA
Am J Physiol Lung Cell Mol Physiol 287:L1-23. 2004..This article provides a brief review of the most promising proteomics methods and some of their applications to pulmonary research... - Direct visual instillation as a method for efficient delivery of fluid into the distal airspaces of anesthetized miceXiao Su
Cardiovascular Research Institute, University of California, San Francisco, CA 94143-0130, USA
Exp Lung Res 30:479-93. 2004..This method should be valuable for experimental lung studies in mice... - Single-nucleotide polymorphisms in the β-adrenergic receptor genes are associated with lung allograft utilizationAnil Sapru
Department of Pediatrics, Cardiovascular Research Institute, University of California San Francisco, San Franscisco, California 94143, USA
J Heart Lung Transplant 30:211-7. 2011..We hypothesized that SNPs in βAR genes would be associated with rates of utilization of donor lung allografts offered for transplantation... - Acute effects of tidal volume strategy on hemodynamics, fluid balance, and sedation in acute lung injuryIvan W Cheng
Cardiovascular Research Institute, University of California, San Francisco, USA
Crit Care Med 33:63-70; discussion 239-40. 2005..Therefore, concerns regarding potential adverse effects of this protocol should not preclude its use in patients with acute lung injury or the acute respiratory distress syndrome... - Priming with endotoxin increases acute lung injury in mice by enhancing the severity of lung endothelial injuryJoyce S Lee
Cardiovascular Research Institute, University of California San Francisco, San Francisco, California 94143, USA
Anat Rec (Hoboken) 294:165-72. 2011..This model should be useful to investigators studying ALI who want to simulate the clinical setting in which more than one insult often leads to greater clinical lung injury... - Recent advances in mechanical ventilationCarolyn S Calfee
Cardiovascular Research Institute, San Francisco, California, USA
Am J Med 118:584-91. 2005..This article critically reviews the most important recent advances in mechanical ventilation and suggests future directions for further research in the field... - High tidal volume ventilation induces NOS2 and impairs cAMP- dependent air space fluid clearanceJames A Frank
Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
Am J Physiol Lung Cell Mol Physiol 284:L791-8. 2003..Because air space edema fluid inactivates surfactant and reduces ventilated lung volume, the reduction of cAMP-dependent AFC by reactive nitrogen species may be an important mechanism of clinical ventilator-associated lung injury... - Contribution of CFTR to apical-basolateral fluid transport in cultured human alveolar epithelial type II cellsXiaohui Fang
Cardiovascular Research Inst, Department of Medicine Physiology, Univ of California, San Francisco, CA 94143 0130, USA
Am J Physiol Lung Cell Mol Physiol 290:L242-9. 2006..We conclude that CFTR is expressed in cultured human AT II cells and may contribute to cAMP-regulated apical-basolateral fluid transport... - High prevalence of pulmonary arterial thrombi in donor lungs rejected for transplantationLorraine B Ware
Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
J Heart Lung Transplant 24:1650-6. 2005..The secondary objective was to better define the spectrum of histologic abnormalities in the same group of lungs... - Alveolar epithelium: role in lung fluid balance and acute lung injuryMichael A Matthay
Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94143 0624, USA
Proc Am Thorac Soc 2:206-13. 2005..Clinical trials are needed to test this potential therapeutic strategy in patients with acute lung injury... - Protective effect of endogenous beta-adrenergic tone on lung fluid balance in acute bacterial pneumonia in miceXiao Su
Cardiovascular Research Institute, Univ of California, San Francisco, CA 94143 0130, USA
Am J Physiol Lung Cell Mol Physiol 290:L769-L776. 2006..coli pneumonia in mice by two mechanisms: 1) reducing lung vascular injury and 2) upregulating the resolution of alveolar edema... - Protective mechanisms of activated protein C in severe inflammatory disordersArne P Neyrinck
University of California San Francisco, Cardiovascular Research Institute, San Francisco, CA, USA
Br J Pharmacol 158:1034-47. 2009..On the whole, these studies have not supported the use of APC in these populations and challenge the field of APC research to search for additional answers... - Invited review: Active fluid clearance from the distal air spaces of the lungMichael A Matthay
University of California, San Francisco, California 94143 0624, USA
J Appl Physiol 93:1533-41. 2002..The new insights into the role of the distal lung epithelium in actively regulating lung fluid balance has important implications for the resolution of clinical pulmonary edema... - Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in ratsJan Hirsch
Mass Spectrometry Facility, Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143 0446, USA
Mol Cell Proteomics 5:979-86. 2006..The ability to simultaneously monitor several pathways involved in reperfusion stress may result in important mechanistic insight and possibly new treatment options... - Transforming growth factor beta1 inhibits cystic fibrosis transmembrane conductance regulator-dependent cAMP-stimulated alveolar epithelial fluid transport via a phosphatidylinositol 3-kinase-dependent mechanismJeremie Roux
Laboratory of Surgical Research, Department of Anesthesia, University of California, San Francisco, California 94110, USA
J Biol Chem 285:4278-90. 2010.... - Fas and fas ligand are up-regulated in pulmonary edema fluid and lung tissue of patients with acute lung injury and the acute respiratory distress syndromeKurt H Albertine
Division of Respiratory, Critical Care, and Occupational Pulmonary Medicine, University of Utah, Salt Lake City 84132, USA
Am J Pathol 161:1783-96. 2002.... - Bone marrow-derived cells participate in stromal remodeling of the lung following acute bacterial pneumonia in miceVladimir B Serikov
Children s Hospital Oakland Research Institute, 5700 Martin Luther King Jr Way, Oakland, CA 94609, USA
Lung 186:179-90. 2008.... - Cytokine-mediated inflammation in acute lung injuryRichard B Goodman
Medical Research Service, Department of Veterans Affairs, VA Puget Sound Health Care System, VA Puget Sound Medical Center, Division of Pulmonary and Critical Care, University of Washington School of Medicine, Seattle, WA 98108, USA
Cytokine Growth Factor Rev 14:523-35. 2003..Further research is needed to establish the contribution of cytokines to both the pathogenesis and resolution of ALI... - Effect of continuous hemofiltration on hemodynamics, lung inflammation and pulmonary edema in a canine model of acute lung injuryXiao Su
Research Institute of Respiratory Diseases, Zhongshan Hospital, Fudan University, Shanghai, P.R. China
Intensive Care Med 29:2034-42. 2003.... - Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndromeAkitoshi Ishizaka
Department of Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582 Japan
Am J Physiol Lung Cell Mol Physiol 286:L1088-94. 2004.... - Functional identification of the alveolar edema reabsorption activity of murine tumor necrosis factor-alphaNadia Elia
Division of Anesthesiological Investigations, University Medical Center, Geneva, Switzerland
Am J Respir Crit Care Med 168:1043-50. 2003..There was also a significant reduction in lung water. These results indicate that the receptor-independent lectin-like domain of mTNF-alpha has a potential physiological role in the resolution of alveolar edema in rats and mice... - Early elevation of plasma soluble intercellular adhesion molecule-1 in pediatric acute lung injury identifies patients at increased risk of death and prolonged mechanical ventilationHeidi R Flori
Department of Pediatric Critical Care, Children s Hospital and Research Center, Oakland, Oakland, CA 94609, USA
Pediatr Crit Care Med 4:315-21. 2003.... - Protein C and thrombomodulin in human acute lung injuryLorraine B Ware
Vanderbilt Univ School of Medicine, Nashville, TN 37232 2650, USA
Am J Physiol Lung Cell Mol Physiol 285:L514-21. 2003..In summary, the protein C system is markedly disrupted in patients with ALI/ARDS from both septic and nonseptic causes. The protein C system may be a potential therapeutic target in patients with ALI/ARDS... - Elevated levels of plasminogen activator inhibitor-1 in pulmonary edema fluid are associated with mortality in acute lung injuryPriya Prabhakaran
Department of Pediatrics, University of Alabama, Birmingham, Alabama 35294, USA
Am J Physiol Lung Cell Mol Physiol 285:L20-8. 2003..The data indicate that fibrin turnover in early ALI is a consequence of a rapid fibrinogen influx and fractional fibrinolytic inhibition... - Selected contribution: mechanisms that may stimulate the resolution of alveolar edema in the transplanted human lungLorraine B Ware
Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 2650, USA
J Appl Physiol 93:1869-74. 2002..Aerosolized beta(2)-adrenergic agonists may have therapeutic value for hastening the resolution of alveolar edema during the management of donors before resection of lungs for transplantation or in the posttransplant setting... - Hypoxia and beta 2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cellsCarole Planes
Department of Physiology, INSERM U426, Universite Paris 7, 75018 Paris, France
J Biol Chem 277:47318-24. 2002.... - Time-dependent effect of pneumonectomy on alveolar epithelial fluid clearance in rat lungsTsutomu Sakuma
Department of Thoracic Surgery, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
J Thorac Cardiovasc Surg 124:668-74. 2002..Because pneumonectomy initiates compensatory growth of the remaining lung, we determined the time-dependent effects of pneumonectomy on alveolar fluid clearance capacity... - Activity of pulmonary edema fluid interleukin-8 bound to alpha(2)-macroglobulin in patients with acute lung injuryAnna K Kurdowska
Department of Biochemistry, University of Texas Health Center, Tyler, Texas 75708, USA
Am J Physiol Lung Cell Mol Physiol 282:L1092-8. 2002..Furthermore, IL-8 bound to alpha(2)-M retained its biological activity, and this fraction of IL-8 was protected from proteolytic degradation. Thus complex formation may modulate the acute inflammatory process in the lung... - Transgenic overexpression of granulocyte macrophage-colony stimulating factor in the lung prevents hyperoxic lung injuryRobert Paine
Division of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, Michigan 48105, USA
Am J Pathol 163:2397-406. 2003.... - Proinflammatory activity of anti-IL-8 autoantibody:IL-8 complexes in alveolar edema fluid from patients with acute lung injuryAgnieszka Krupa
Department of Biochemistry, University of Texas Health Center, 11937 US Highway 271, Tyler, TX 75708 3154, USA
Am J Physiol Lung Cell Mol Physiol 286:L1105-13. 2004..e., ERK and p38, important components of the FcgammaRIIa signaling cascade. Anti-IL-8:IL-8 complexes may therefore be involved in the pathogenesis of lung inflammation in clinical acute lung injury... - Evidence of temporary airway epithelial repopulation and rare clonal formation by BM-derived cells following naphthalene injury in miceVladimir B Serikov
Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
Anat Rec (Hoboken) 290:1033-45. 2007..These data confirm that bone marrow-derived cultured mesenchymal cells can participate in the recovery of the injured airway epithelium after naphthalene-induced injury with minimal long-term engraftment... - Alveolar edema fluid clearance and acute lung injuryYves Berthiaume
Département de médecine et Centre de recherche du Centre Hospitalier de l Université de Montréal, Universite de Montreal, Montreal, Quebec, Canada
Respir Physiol Neurobiol 159:350-9. 2007.... - Postobstructive pulmonary edema: a case for hydrostatic mechanismsRichard D Fremont
Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University, T1218 MCN, 1161 Twenty First Ave S, Nashville, TN 37232 2650, USA
Chest 131:1742-6. 2007..The goal of the current study was to investigate the mechanisms of pulmonary edema formation in patients with postobstructive pulmonary edema by serial sampling of undiluted pulmonary edema fluid... - Treatment of acute lung injury: historical perspective and potential future therapiesJoseph E Levitt
Division of Pulmonary and Critical Care, Stanford University, Stanford, California 94305, USA
Semin Respir Crit Care Med 27:426-37. 2006..This article focuses on clinical treatments for ALI that have been tested in phase II and III clinical trials as well as a discussion of potential future therapies... - Integrating acute lung injury and regulation of alveolar fluid clearanceDavid M Guidot
Emory University School of Medicine, Atlanta, Georgia, USA
Am J Physiol Lung Cell Mol Physiol 291:L301-6. 2006.... - Alveolar epithelial ion and fluid transport: recent progressHans G Folkesson
Department of Physiology and Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown, USA
Am J Respir Cell Mol Biol 35:10-9. 2006 - Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrineTsutomu Sakuma
Thoracic Surgery, Kanazawa Medical University, Uchinada, Ishikawa, Japan
Crit Care Med 34:676-81. 2006.... - Receptor for advanced glycation end-products is a marker of type I cell injury in acute lung injuryTokujiro Uchida
Department of Anesthesiology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
Am J Respir Crit Care Med 173:1008-15. 2006..Receptor for advanced glycation end-products (RAGE) is one of the alveolar type I cell-associated proteins in the lung... - Significance of von Willebrand factor in septic and nonseptic patients with acute lung injuryLorraine B Ware
Division of Allergy, Pulmonary and Critical Care Medicine, T1217 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232 2650, USA
Am J Respir Crit Care Med 170:766-72. 2004..To improve outcomes further, new treatment strategies targeted at the endothelium should be investigated... - Malnutrition impairs alveolar fluid clearance in rat lungsTsutomu Sakuma
Department of Thoracic Surgery, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
Am J Physiol Lung Cell Mol Physiol 286:L1268-74. 2004.... - Proteomic analysis of pulmonary edema fluid and plasma in patients with acute lung injuryRussell P Bowler
National Jewish Medical and Research Center, K736a, 1400 Jackson St, Denver, CO 80206, USA
Am J Physiol Lung Cell Mol Physiol 286:L1095-104. 2004..Nearly all ALI patients also had protein spots that indicate truncation or other posttranslational modifications. Several of these novel changes could serve as new biomarkers of lung injury... - Distal air space epithelial fluid clearance in near-term rat fetuses is fast and requires endogenous catecholaminesHans G Folkesson
Department of Physiology, Northeastern Ohio Universities College of Medicine, Rootstown, Ohio 44272 0095, USA
Am J Physiol Lung Cell Mol Physiol 282:L508-15. 2002..In conclusion, these studies demonstrate that 1) rapid rates of net alveolar fluid clearance occur late in gestation in the rat and 2) this clearance is driven by elevations of endogenous epinephrine...
Research Grants
- RESOLUTION OF CLINICAL LUNG INJURYMichael Matthay; Fiscal Year: 2005....
- MECHANISMS OF ALVEOLAR EPITHELIAL FLUID CLEARANCEMichael Matthay; Fiscal Year: 2007..Overall, these studies will provide important new insights into the basic mechanisms that regulate epithelial fluid transport and lung fluid balance in the normal and the injured lung. ..
- MECHANISMS OF ALVEOLAR EPITHELIAL FLUID CLEARANCEMichael Matthay; Fiscal Year: 2002..The information provided from these experimental studies should provide new strategies for accelerating the resolution of hydrostatic or increased permeability pulmonary edema in humans. ..
- ALVEOLAR EPITHELIAL BARRIER IN CLINICAL LUNG INJURYMichael Matthay; Fiscal Year: 2000....
- Lung Fluid Balance and Mesenchymal Stem CellsMichael A Matthay; Fiscal Year: 2010....