Rae R Matsumoto

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. ncbi request reprint N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice
    R R Matsumoto
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Eur J Pharmacol 411:261-73. 2001
  2. ncbi request reprint (+/-)-SM 21 attenuates the convulsive and locomotor stimulatory effects of cocaine in mice
    R R Matsumoto
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, P O Box 26901, CPB 337 73190, Oklahoma City, OK, USA
    Eur J Pharmacol 417:R1-2. 2001
  3. ncbi request reprint Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice
    R R Matsumoto
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    Eur J Pharmacol 419:163-74. 2001
  4. ncbi request reprint Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters
    R R Matsumoto
    Dept of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190, USA
    Neuropharmacology 41:878-86. 2001
  5. ncbi request reprint Involvement of sigma receptors in the behavioral effects of cocaine: evidence from novel ligands and antisense oligodeoxynucleotides
    Rae R Matsumoto
    Department of Pharmaceutical Sciences, P O Box 26901, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Neuropharmacology 42:1043-55. 2002
  6. ncbi request reprint Structure-activity comparison of YZ-069, a novel sigma ligand, and four analogs in receptor binding and behavioral studies
    Rae R Matsumoto
    Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190, USA
    Pharmacol Biochem Behav 77:775-81. 2004
  7. ncbi request reprint Sigma receptors: potential medications development target for anti-cocaine agents
    Rae R Matsumoto
    Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, P O Box 26901, CPB 337, Oklahoma City, OK 73190, USA
    Eur J Pharmacol 469:1-12. 2003
  8. pmc Effects of UMB24 and (+/-)-SM 21, putative sigma2-preferring antagonists, on behavioral toxic and stimulant effects of cocaine in mice
    Rae R Matsumoto
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Pharmacol Biochem Behav 86:86-91. 2007
  9. ncbi request reprint Novel analogs of the sigma receptor ligand BD1008 attenuate cocaine-induced toxicity in mice
    Rae R Matsumoto
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, P O Box 26901, CPB 337 Oklahoma City, OK 73190, USA
    Eur J Pharmacol 492:21-6. 2004
  10. ncbi request reprint N-[2-(m-methoxyphenyl)ethyl]-N-ethyl-2-(1-pyrrolidinyl)ethylamine (UMB 116) is a novel antagonist for cocaine-induced effects
    AnTawan Daniels
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Eur J Pharmacol 542:61-8. 2006

Collaborators

  • Ying Zhang
  • William E Fantegrossi
  • S M Husbands
  • T Maurice
  • Remi Martin-Fardon
  • Jacques Poupaert
  • Andrew Coop
  • Yun Liu
  • Lidiya Stavitskaya
  • Jamaluddin Shaikh
  • Buddy Pouw
  • Anna J Kochanowska
  • Jiajia Wang
  • William C Motel
  • Jason R Healy
  • Deborah L Gilmore
  • Michael J Seminerio
  • Eddy Viard
  • James A Fishback
  • Christophe Mesangeau
  • Mark T Hamann
  • Trudy A Smith
  • Susan L Mercer
  • Abir El-Alfy
  • Jeffrey A Diers
  • Matthew K Brammer
  • AnTawan Daniels
  • Huifang Wu
  • Emily C Nguyen
  • Weibin Chen
  • Abby Foster
  • Bahar Noorbakhsh
  • Kelly E Martin
  • Marilyn M Matthews-Tsourounis
  • Andrea M Green
  • Nidhi Kaushal
  • Gina S Stewart
  • Suzanne Childress
  • Christopher R McCurdy
  • Yan Tong Xu
  • Kenneth J Sufka
  • K A McCracken
  • John R Traynor
  • Sanju Narayanan
  • Xiaowen Yang
  • Kelly D Ivey
  • John F Stoker
  • Michelle Kelly
  • Sheketta Brown
  • Karumanchi V Rao
  • Aisha L Mack
  • Erika Ayala
  • Megan R Lerner
  • Kari A McCracken
  • Guang Di Chen
  • Daniel J Brackett
  • Wayne D Bowen
  • Wanda Williams
  • W D Bowen

Detail Information

Publications29

  1. ncbi request reprint N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice
    R R Matsumoto
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Eur J Pharmacol 411:261-73. 2001
    ..Together, the data demonstrate that BD1008, BD1060 or BD1067 can attenuate the behavioral toxicity of cocaine, most likely through functional antagonism of sigma receptors...
  2. ncbi request reprint (+/-)-SM 21 attenuates the convulsive and locomotor stimulatory effects of cocaine in mice
    R R Matsumoto
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, P O Box 26901, CPB 337 73190, Oklahoma City, OK, USA
    Eur J Pharmacol 417:R1-2. 2001
    ..Pre-treatment of Swiss Webster mice with (+/-)-SM 21 significantly attenuated cocaine-induced convulsions and locomotor activity...
  3. ncbi request reprint Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice
    R R Matsumoto
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    Eur J Pharmacol 419:163-74. 2001
    ..Together, the data suggests that functional antagonism of sigma receptors is capable of attenuating a number of cocaine-induced behaviors...
  4. ncbi request reprint Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters
    R R Matsumoto
    Dept of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190, USA
    Neuropharmacology 41:878-86. 2001
    ..These data thus suggest that sigma receptors may mediate some of the toxic effects associated with cocaine and that sigma receptor antagonists may be developed as pharmacotherapeutic agents for this application...
  5. ncbi request reprint Involvement of sigma receptors in the behavioral effects of cocaine: evidence from novel ligands and antisense oligodeoxynucleotides
    Rae R Matsumoto
    Department of Pharmaceutical Sciences, P O Box 26901, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Neuropharmacology 42:1043-55. 2002
    ..Together, the studies support the involvement of sigma receptors, particularly the sigma(1) subtype, in the behavioral effects of cocaine...
  6. ncbi request reprint Structure-activity comparison of YZ-069, a novel sigma ligand, and four analogs in receptor binding and behavioral studies
    Rae R Matsumoto
    Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190, USA
    Pharmacol Biochem Behav 77:775-81. 2004
    ....
  7. ncbi request reprint Sigma receptors: potential medications development target for anti-cocaine agents
    Rae R Matsumoto
    Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, P O Box 26901, CPB 337, Oklahoma City, OK 73190, USA
    Eur J Pharmacol 469:1-12. 2003
    ..Together, the studies provide insight and promising future directions for the development of potential medications for the treatment of cocaine addiction and overdose...
  8. pmc Effects of UMB24 and (+/-)-SM 21, putative sigma2-preferring antagonists, on behavioral toxic and stimulant effects of cocaine in mice
    Rae R Matsumoto
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Pharmacol Biochem Behav 86:86-91. 2007
    ..Together, the data suggest that sigma2 receptor antagonists have the potential to attenuate some of the behavioral effects of cocaine, and further development of more selective, high affinity ligands are warranted...
  9. ncbi request reprint Novel analogs of the sigma receptor ligand BD1008 attenuate cocaine-induced toxicity in mice
    Rae R Matsumoto
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, P O Box 26901, CPB 337 Oklahoma City, OK 73190, USA
    Eur J Pharmacol 492:21-6. 2004
    ..Together with earlier studies, the data suggest that analogs of BD1008 are promising medication development leads for reducing the toxicity of cocaine...
  10. ncbi request reprint N-[2-(m-methoxyphenyl)ethyl]-N-ethyl-2-(1-pyrrolidinyl)ethylamine (UMB 116) is a novel antagonist for cocaine-induced effects
    AnTawan Daniels
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73190, USA
    Eur J Pharmacol 542:61-8. 2006
    ..All three compounds significantly (P<0.05) altered the locomotor stimulatory effects of cocaine, with UMB115 and UMB116 exhibiting attenuating actions. Together, the studies suggest UMB116 as a novel cocaine antagonist...
  11. pmc Interactions between 3,4-methylenedioxymethamphetamine and sigma1 receptors
    Matthew K Brammer
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73190 USA
    Eur J Pharmacol 553:141-5. 2006
    ..Together, the data support the functional relevance of the interaction of MDMA with sigma(1) receptors, and suggest that these receptors are involved in the stimulant actions of MDMA...
  12. ncbi request reprint Involvement of sigma (sigma) receptors in the acute actions of methamphetamine: receptor binding and behavioral studies
    Emily C Nguyen
    Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK 73190, USA
    Neuropharmacology 49:638-45. 2005
    ..Together, the data suggest that sigma1 receptors are involved in the acute actions of methamphetamine and that antagonism of this subtype is sufficient to prevent the locomotor stimulatory effects of methamphetamine...
  13. doi request reprint Effect of ring-constrained phenylpropyloxyethylamines on sigma receptors
    Lidiya Stavitskaya
    Department of Pharmaceutical Sciences, University of Maryland, School of Pharmacy, 20 N Pine Street, Baltimore, MD 21201, USA
    Bioorg Med Chem 21:4923-7. 2013
    ..In addition, compounds 6 and 9 significantly reduced the convulsive effects of cocaine in mice, which would be consistent with antagonism of σ receptors. ..
  14. ncbi request reprint Novel sigma receptor ligands attenuate the locomotor stimulatory effects of cocaine
    K A McCracken
    University of Oklahoma Health Sciences Center, College of Pharmacy, Department of Pharmacology and Toxicology, Oklahoma City 73190, USA
    Eur J Pharmacol 365:35-8. 1999
    ..These results suggest that sigma receptors are involved in the behavioral effects of cocaine...
  15. ncbi request reprint 1,4-dibenzylpiperazines possess anticocaine activity
    Abby Foster
    Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 North Pine Street, Baltimore, MD 21201, USA
    Bioorg Med Chem Lett 13:749-51. 2003
    ....
  16. pmc Trifluoromethoxyl substituted phenylethylene diamines as high affinity sigma receptor ligands with potent anti-cocaine actions
    Trudy A Smith
    Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, MD 21201, USA
    J Med Chem 51:3322-5. 2008
    ..The para-substituted trifluoromethoxyl substituted analogues were shown to have increased sigma receptor affinity and represent the most potent anti-cocaine phenylethylene diamines yet described...
  17. pmc Effects of the selective sigma receptor ligand, 1-(2-phenethyl)piperidine oxalate (AC927), on the behavioral and toxic effects of cocaine
    Rae R Matsumoto
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, USA
    Drug Alcohol Depend 118:40-7. 2011
    ..Earlier studies have shown that cocaine and many other abused substances interact with sigma receptors and that antagonism of these proteins can mitigate their actions...
  18. pmc The effect of the pyridyl nitrogen position in pyridylpiperazine sigma ligands
    Lidiya Stavitskaya
    Department of Pharmaceutical Sciences, University of Maryland, School of Pharmacy, Baltimore, MD 21201, USA
    Bioorg Med Chem Lett 20:2564-5. 2010
    ..The (3-pyridyl)piperazines and (4-pyridyl)piperazines favor sigma(1) receptors, while previously studied (2-pyridyl)piperazines favor sigma(2) receptors...
  19. pmc Relationship between methamphetamine exposure and matrix metalloproteinase 9 expression
    Yun Liu
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Neuroreport 19:1407-9. 2008
    ..The data suggest that MMP9 expression does not contribute to methamphetamine-induced neurotoxicity, and may instead be involved in remodeling of the nervous system...
  20. doi request reprint Alterations in fos-related antigen 2 and sigma1 receptor gene and protein expression are associated with the development of cocaine-induced behavioral sensitization: time course and regional distribution studies
    Yun Liu
    Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    J Pharmacol Exp Ther 327:187-95. 2008
    ..These data suggest that repeated exposure to cocaine elicits alterations in fra-2 and sigma(1) receptor-mediated mechanisms, which ultimately manifest as altered behavioral responses to cocaine...
  21. ncbi request reprint Review of the pharmacological and clinical profile of rimcazole
    Deborah L Gilmore
    Department of Pharmaceutical Sciences, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    CNS Drug Rev 10:1-22. 2004
    ....
  22. doi request reprint Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands
    William C Motel
    Department of Pharmaceutical Sciences, University of Maryland, School of Pharmacy, 20 North Pine Street, Baltimore, MD 21201, USA
    Bioorg Med Chem Lett 23:6920-2. 2013
    ....
  23. pmc Nitrile analogs of meperidine as high affinity and selective sigma-1 receptor ligands
    Susan L Mercer
    Department of Pharmaceutical Sciences, University of Maryland, School of Pharmacy, 20 Penn Street, Baltimore, MD 21201, USA
    Eur J Med Chem 43:1304-8. 2008
    ..The N-isobutyl, N-phenylpropyl, and N-benzyl analogs are worth pursuing due to their good affinity and selectivity at the sigma(1) receptor, whereas the N-benzyl analog exhibits the greatest selectivity for sigma(1)...
  24. doi request reprint Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activity
    Christophe Mesangeau
    Department of Medicinal Chemistry, The University of Mississippi, Mississippi 38677, USA
    J Med Chem 51:1482-6. 2008
    ..Among the synthesized compounds was produced a subnanomolar sigma-2 ligand with an 11-fold preference over sigma-1 receptors. These compounds may be useful in developing effective pharmacotherapies for cocaine toxicity...
  25. ncbi request reprint Novel sigma (sigma) receptor agonists produce antidepressant-like effects in mice
    Jiajia Wang
    Department of Pharmacology, University of Mississippi, University, MS 38677, USA
    Eur Neuropsychopharmacol 17:708-16. 2007
    ..Together, the data provide further evidence that sigma receptor agonists represent a possible new class of antidepressant medication...
  26. ncbi request reprint Cocaine up-regulates Fra-2 and sigma-1 receptor gene and protein expression in brain regions involved in addiction and reward
    Yun Liu
    University of Mississippi, Department of Pharmacology, 303 Faser Hall, University, MS 38677, USA
    J Pharmacol Exp Ther 314:770-9. 2005
    ....
  27. doi request reprint Secondary metabolites from three Florida sponges with antidepressant activity
    Anna J Kochanowska
    Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA
    J Nat Prod 71:186-9. 2008
    ..The current study provides ample evidence that marine natural products with the diversity of brominated marine alkaloids will provide potential leads for antidepressant and anxiolytic drugs...
  28. ncbi request reprint Identification of antidepressant drug leads through the evaluation of marine natural products with neuropsychiatric pharmacophores
    Jeffrey A Diers
    The Department of Pharmacology, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, MS 38677, USA
    Pharmacol Biochem Behav 89:46-53. 2008
    ..These studies highlight the potential to rationally select marine derived compounds for treating depression and other neuropsychiatric disorders...
  29. ncbi request reprint Sigma(1) (sigma(1)) receptor antagonists represent a new strategy against cocaine addiction and toxicity
    Tangui Maurice
    CNRS UMR 5102, University of Montpellier II, c c 090, Place Eugene Bataillon, 34095 Montpellier Cedex 5, France
    Neurosci Biobehav Rev 26:499-527. 2002
    ..The therapeutic potentials and neuropharmacological perspectives opened by the use of selective sigma(1) receptor antagonists in cocaine addiction will finally be discussed...