Research Topics
Species | Chester MathisSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Publications
Development of positron emission tomography β-amyloid plaque imaging agentsChester A Mathis
Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Semin Nucl Med 42:423-32. 2012..It is likely that the full clinical impact of these imaging agents will be realized by identifying presymptomatic subjects who would benefit from early drug treatments with future disease-modifying AD therapeutics...- Impact of amyloid imaging on drug development in Alzheimer's diseaseChester A Mathis
Department of Radiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
Nucl Med Biol 34:809-22. 2007.... 
Imaging beta-amyloid plaques and neurofibrillary tangles in the aging human brainC A Mathis
Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Curr Pharm Des 10:1469-92. 2004..Imaging NFTs, separately or in concert with A beta plaques, is not as far advanced as imaging A beta plaques and remains to be fully characterized and demonstrated...- Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's diseaseScott K Ziolko
Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Rm. B-938, PA 15213, USA
Neuroimage 33:94-102. 2006..These results indicate that voxel-based methods will be useful for future larger longitudinal studies of amyloid deposition that could improve AD diagnosis and anti-amyloid therapy assessment... - Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer diseaseClayton A Wiley
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Arch Neurol 66:60-7. 2009..Because postmortem histopathological analyses are limited to single end-stage assessment, the time course and nature of this relationship are not well understood... - Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's diseaseMilos D Ikonomovic
Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Brain 131:1630-45. 2008..The strong direct correlation of in vivo PiB retention with region-matched quantitative analyses of Abeta plaques in the same subject supports the validity of PiB-PET imaging as a method for in vivo evaluation of Abeta plaque burden... - Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivativeWilliam E Klunk
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
J Neuropathol Exp Neurol 61:797-805. 2002.... - Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635Ursula F Bailer
Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Arch Gen Psychiatry 62:1032-41. 2005..These psychobiological alterations may be trait related and may contribute to the pathogenesis of AN... - Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-BWilliam E Klunk
Department of Psychiatry, PET Facility, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213-2582, USA
Ann Neurol 55:306-19. 2004..This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects... - Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserveAnn D Cohen
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Neurosci 29:14770-8. 2009.... - Cognitive correlates of alterations in acetylcholinesterase in Alzheimer's diseaseNicolaas I Bohnen
Department of Neurology, University of Pittsburgh Medical School, Liliane S Kaufmann Building, Suite 811, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
Neurosci Lett 380:127-32. 2005..Similar findings were present when the analysis was limited to the temporal cortex. Cortical AChE activity is more robustly associated with functions of attention and working memory compared to performance on primary memory tests in AD... - PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PETSriram Venneti
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Neurobiol Aging 30:1217-26. 2009.... - Frequent amyloid deposition without significant cognitive impairment among the elderlyHoward Jay Aizenstein
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Arch Neurol 65:1509-17. 2008.... - Imaging of amyloid burden and distribution in cerebral amyloid angiopathyKeith A Johnson
Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
Ann Neurol 62:229-34. 2007.... - Longitudinal in vivo positron emission tomography imaging of infected and activated brain macrophages in a macaque model of human immunodeficiency virus encephalitis correlates with central and peripheral markers of encephalitis and areas of synaptic degeSriram Venneti
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Am J Pathol 172:1603-16. 2008..A combination of PET imaging and the assessment of these peripheral immune parameters may facilitate longitudinal assessment of lentiviral encephalitis in living patients as well as evaluation of therapeutic efficacies... - X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's diseaseMilos D Ikonomovic
Department of Neurology and Psychiatry, University of Pittsburgh, Pennsylvania 15213, USA
Methods Enzymol 412:123-44. 2006.... - A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activationSriram Venneti
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Neurochem 102:2118-31. 2007.... - Consideration of optimal time window for Pittsburgh compound B PET summed uptake measurementsREBECCA L MCNAMEE
Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Nucl Med 50:348-55. 2009..In this work, regional PiB SUVRs were examined across 9 time windows to select the window that provided the best trade-offs between bias, correlation, and effective contrast... - Exaggerated 5-HT1A but normal 5-HT2A receptor activity in individuals ill with anorexia nervosaUrsula F Bailer
Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, Pittsburgh, University of Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 61:1090-9. 2007..Because little is known about 5-HT receptor function in AN, positron emission tomography (PET) imaging with 5-HT receptor-specific radioligands was used to characterize 5-HT1A and 5-HT2A receptors... - Amyloid imaging in mild cognitive impairment subtypesDavid A Wolk
Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 19104, USA
Ann Neurol 65:557-68. 2009.... 
Human biodistribution and dosimetry of the D2/3 agonist 11C-N-propylnorapomorphine (11C-NPA) determined from PETCharles M Laymon
Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Nucl Med 50:814-7. 2009..We measured the whole-body distribution of intravenously injected (11)C-N-propylnorapomorphine ((11)C-NPA), a dopamine agonist PET tracer, in human subjects and determined the resulting absorbed radiation doses...- Three-dimensional surface mapping of the caudate nucleus in late-life depressionMeryl A Butters
Department of Psychiatry, University of Pittsburgh, and Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
Am J Geriatr Psychiatry 17:4-12. 2009.... - Two-year follow-up of amyloid deposition in patients with Alzheimer's diseaseWilliam E Klunk
University of Pittsburgh Medical School Pittsburgh, MA, USA
Brain 129:2805-7. 2006 - Measurement of 5-HT1A receptor binding in depressed adults before and after antidepressant drug treatment using positron emission tomography and [11C]WAY-100635Eydie L Moses-Kolko
Departments of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Synapse 61:523-30. 2007..To assess effects of chronic antidepressant drug treatment on serotonin type-1A receptor (5-HT(1A)R) binding potential (BP) in major depressive disorder... - Serotonin transporter binding after recovery from eating disordersUrsula F Bailer
Western Psychiatric Institute and Clinic, University of Pittsburgh, Iroquois Building, Suite 600, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Psychopharmacology (Berl) 195:315-24. 2007..Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN)... - Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigreesWilliam E Klunk
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
J Neurosci 27:6174-84. 2007..The early, focal striatal amyloid deposition observed in these PS1 mutation carriers is often is not associated with clinical symptoms... - The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imagingSriram Venneti
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Exp Neurol 207:118-27. 2007.... - Tiagabine increases [11C]flumazenil binding in cortical brain regions in healthy control subjectsW Gordon Frankle
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 34:624-33. 2009.... - No effect of dopamine depletion on the binding of the high-affinity D 2/3 radiotracer [11C]FLB 457 in the human cortexW Gordon Frankle
Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Synapse 64:879-85. 2010..In contrast to the measurement of DA release, the combination of low D(2) receptor density and low basal DA levels in the cortex greatly reduce the power to detect alterations in [(11)C]FLB 457 binding secondary to DA depletion... - Positron emission tomography imaging of dopamine D₂/₃ receptors in the human cortex with [¹¹C]FLB 457: reproducibility studiesRajesh Narendran
Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Synapse 65:35-40. 2011..These data support the further validation of [¹¹C]FLB 457 as a tool to measure amphetamine-induced dopamine release in the human cortex... - A comparative evaluation of the dopamine D(2/3) agonist radiotracer [11C](-)-N-propyl-norapomorphine and antagonist [11C]raclopride to measure amphetamine-induced dopamine release in the human striatumRajesh Narendran
Department of Radiology, University of Pittsburgh Medical Center Presbyterian, PET Facility, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Pharmacol Exp Ther 333:533-9. 2010..Nevertheless, these data add to the growing literature that suggests D(2/3) agonist radiotracers are more vulnerable to endogenous competition by dopamine than existing D(2/3) antagonist radiotracers... - Positron emission tomography imaging of D(2/3) agonist binding in healthy human subjects with the radiotracer [(11)C]-N-propyl-norapomorphine: preliminary evaluation and reproducibility studiesRajesh Narendran
Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Synapse 63:574-84. 2009..The aim of the present study was to define the optimal analytic method to derive accurate and reliable D(2/3) receptor parameters with [(11)C]NPA... - Synthesis and beta-amyloid binding properties of rhenium 2-phenylbenzothiazolesKuo Shyan Lin
Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
Bioorg Med Chem Lett 19:2258-62. 2009.... - Effects of lipophilicity on the affinity and nonspecific binding of iodinated benzothiazole derivativesYanming Wang
P E T Facility, Department of Radiology, Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Mol Neurosci 20:255-60. 2003..These results provide important SAR information to guide the development of novel amyloid-binding agents and provide further insights into the molecular interaction between 2-aryl benzothiazole ligands and Abeta fibrils... - Positron emission tomography imaging of amphetamine-induced dopamine release in the human cortex: a comparative evaluation of the high affinity dopamine D2/3 radiotracers [11C]FLB 457 and [11C]fallyprideRajesh Narendran
Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Synapse 63:447-61. 2009..These findings suggest that [(11)C]FLB 457 is superior to [(11)C]fallypride for measurement of changes in cortical synaptic dopamine... - The future of amyloid-beta imaging: a tale of radionuclides and tracer proliferationWilliam E Klunk
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Curr Opin Neurol 21:683-7. 2008.... - Whatever happened to Pittsburgh Compound-A?William E Klunk
Department of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Alzheimer Dis Assoc Disord 22:198-203. 2008 - Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-BMeryl A Butters
Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Alzheimer Dis Assoc Disord 22:261-8. 2008..Our findings are consistent with and supportive of the hypothesis that depression may herald the development of AD in some individuals... - A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brainChester A Mathis
PET Facility, Department of Radiology, University of Pittsburgh, PA 15213, USA
Bioorg Med Chem Lett 12:295-8. 2002..Amyloid deposits were imaged with multiphoton microscopy in the brains of living transgenic mice following the systemic injection of unlabeled 6. [(11)C]6 is a promising amyloid imaging agent for Alzheimer's disease... - Serotonin alterations in anorexia and bulimia nervosa: new insights from imaging studiesWalter H Kaye
University of Pittsburgh, School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, United States
Physiol Behav 85:73-81. 2005..Alterations of these circuits may affect mood and impulse control as well as the motivating and hedonic aspects of feeding behavior. Such imaging studies may offer insights into new pharmacology and psychotherapy approaches... - Imaging technology for neurodegenerative diseases: progress toward detection of specific pathologiesChester A Mathis
Department of Neurology, University of Pittsburgh and Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Arch Neurol 62:196-200. 2005.... - Evidence of increased serotonin-1A receptor binding in type 2 diabetes: a positron emission tomography studyJulie C Price
PET Facility, Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop St, Rm B938, Pittsburgh, PA 15213, USA
Brain Res 927:97-103. 2002..02). These findings support previous studies that suggest serotonergic underpinnings to the neurobiology of diabetes and have shown diabetes-induced neurological changes in hippocampus... - Serotonin 1A receptor binding and treatment response in late-life depressionCarolyn Cidis Meltzer
Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA
Neuropsychopharmacology 29:2258-65. 2004..Further, this work indicates that dysfunction in autoreceptor activity may play a central role in the mechanisms underlying treatment response to selective serotonin reuptake inhibitors in late-life depression... - Distribution of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil in mice bearing colorectal cancer xenografts: rationale for therapeutic use and as a positron emission tomography probe for thymidylate synthaseJulie L Eiseman
Molecular Therapeutics Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213 1863, USA
Clin Cancer Res 10:6669-76. 2004..These studies were designed to evaluate FAU as a potential therapeutic and diagnostic probe... - Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomographyWilliam E Klunk
Laboratory of Molecular Neuropharmacology, Department of Psychiatry, University of Pittsburgh School of Medicine, 705 Parran Hall, Pittsburgh, PA 15213, USA
Neuroimaging Clin N Am 13:781-9, ix. 2003..The capability to use positron emission tomography and selective markers for amyloid protein deposition promises to substantially alter the way we diagnosis and manage patients who have AD... - Positron emission tomography radiochemistryN Scott Mason
Positron Emission Tomography Facility, Department of Radiology, University of Pittsburgh, B 938, UPMC Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
Neuroimaging Clin N Am 13:671-87. 2003..Although the number of PET radiotracers synthesized is in the hundreds [6], much work remains to develop specific and useful PET radiotracers for a host of new and exciting noninvasive imaging applications... - Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic studyNicolaas I Bohnen
Departments of Neurology and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Arch Neurol 60:1745-8. 2003..1%), except for regionally selective involvement of the lateral temporal cortex (-15%; P<.001). CONCLUSION: Reduced cortical AChE activity is more characteristic of patients with PDem than of patients with mild AD... - Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agentsChester A Mathis
Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Med Chem 46:2740-54. 2003..The encouraging in vitro and in vivo properties of [(11)C]6-OH-BTA-1 support the choice of this derivative for further evaluation in human subject studies of brain Abeta deposition... - The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid componentWilliam E Klunk
Laboratory of Molecular Neuropharmacology, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
J Neurosci 23:2086-92. 2003..Finally, BTA-1 did not appear to bind significantly to common neuroreceptors or transporter sites. These data suggest that the binding of BTA-1 to AD brain is dominated by a specific interaction with Abeta amyloid deposits... - Synthesis and evaluation of 2-(3'-iodo-4'-aminophenyl)-6-hydroxybenzothiazole for in vivo quantitation of amyloid deposits in Alzheimer's diseaseYanming Wang
PET Facility, Department of Radiology, School of Medicine, University of Pittsburgh, PA 15213, USA
J Mol Neurosci 19:11-6. 2002..43+/-0.62%ID/g detected in the whole brain at 2 min post i.v. injection. At 30 min, the radioactivity concentration decreased to 0.40+/-0.05%ID/g, indicating good clearance in the absence of amyloid deposits in the brain... - Sequential H(2)(15)O PET studies in baboons: before and after amphetamineJulie C Price
Department of Radiology, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
J Nucl Med 43:1090-100. 2002..A common assumption in bolus injection PET studies of this type is that cerebral blood flow (CBF) does not vary during the scan. The goal of this work was to examine the effect of AMPH administration on sequential PET measures of CBF... - Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-BJulie C Price
Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Cereb Blood Flow Metab 25:1528-47. 2005..This study also showed that it is feasible to perform quantitative PIB PET imaging studies that are needed to validate simpler methods for routine use across the AD disease spectrum... - Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairmentClayton A Wiley
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
J Neurovirol 12:262-71. 2006.... - Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11c]racloprideGuido K Frank
Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of California San Diego, California, USA
Biol Psychiatry 58:908-12. 2005..Most intriguing is the possibility that individuals with AN might have a DA related disturbance of reward mechanisms contributing to altered hedonics of feeding behavior and their ascetic, anhedonic temperament... - Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brainWilliam E Klunk
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Neurosci 25:10598-606. 2005.... - Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysisBrian J Lopresti
Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Nucl Med 46:1959-72. 2005..This work reports on simplified methods of analysis for human PIB imaging... - Altered 5-HT(2A) receptor binding after recovery from bulimia-type anorexia nervosa: relationships to harm avoidance and drive for thinnessUrsula F Bailer
Department of Psychiatry, School of Medicine, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
Neuropsychopharmacology 29:1143-55. 2004..It is possible that subgenual cingulate findings are not specific for AN-BN, but may be related to the high incidence of lifetime major depressive disorder diagnosis in these subjects... - Selective hyposmia and nigrostriatal dopaminergic denervation in Parkinson's diseaseNicolaas I Bohnen
Dept of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
J Neurol 254:84-90. 2007..Assessment of selective olfactory deficits may be used as a simplified olfactory screening test in the evaluation of subjects with possible PD... - Regional cerebral blood flow after recovery from anorexia or bulimia nervosaGuido K Frank
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Int J Eat Disord 40:488-92. 2007..Abnormalities of regional cerebral blood flow (rCBF) have been found in individuals who are ill with anorexia (AN) or bulimia nervosa (BN). Little is known about whether rCBF normalizes after recovery from AN and BN... - MR atlas of the baboon brain for functional neuroimagingPhil J Greer
University of Pittsburgh PET Facility, Pittsburgh, PA 15213-2582, USA
Brain Res Bull 58:429-38. 2002..Overall, the digital MR-based atlas allowed for automatic co-registration, proved useful across a range of PET Studies, and is accessible electronically via the Internet... - Grooved pegboard test as a biomarker of nigrostriatal denervation in Parkinson's diseaseNicolaas I Bohnen
Department of Radiology, University of Michigan, Ann Arbor, MI 48109 0028, USA
Neurosci Lett 424:185-9. 2007.... - Targeting proteins in vivo: in vitro guidelinesWilliam C Eckelman
Nucl Med Biol 33:161-4. 2006 - Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic miceBrian J Bacskai
Department of Neurology Alzheimer s Disease Research Laboratory, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA
Proc Natl Acad Sci U S A 100:12462-7. 2003..WT mice showed rapid brain entry and clearance of PIB without any binding. These results demonstrate that the compound PIB has the properties required for a good amyloid-imaging agent in humans with or at risk for AD... - Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenanceTristan Bolmont
Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, D 72076 Tubingen, Germany
J Neurosci 28:4283-92. 2008..These results indicate a role for microglia in plaque maintenance and provide a model with multiple targets for therapeutic intervention... - Discussion of targeting proteins in vivo: in vitro guidelinesWilliam C Eckelman
Nucl Med Biol 33:449-51. 2006 - Imaging of CNS myelin by positron-emission tomographyBruno Stankoff
Institut National de la Sante et de la Recherche Medicale, U711, Hopital de la Salpetriere, F 75013 Paris, France
Proc Natl Acad Sci U S A 103:9304-9. 2006..Our results provide a perspective for developing a brain myelin imaging technique by positron-emission tomography... - Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case reportBrian J Bacskai
MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Charlestown, MA 02129, USA
Arch Neurol 64:431-4. 2007..Imaging revealed marked region specific binding of PiB and abnormal fluorodeoxyglucose uptake. Intervention Autopsy was performed 3 months after the PiB scan... - Imaging amyloid-beta deposits in vivoBrian J Bacskai
Alzheimer Research Unit, Massachusetts General Hospital, Charlestown 02129, USA
J Cereb Blood Flow Metab 22:1035-41. 2002..This review describes the progress in developing reagents suitable for in vivo imaging of senile plaques... - Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's diseaseKerryn E Pike
School of Psychology, Psychiatry and Psychological Medicine, Monash University, Melbourne, Australia
Brain 130:2837-44. 2007..The data also suggests that early intervention trials for AD targeted to non-demented individuals with cerebral Abeta deposition are warranted... - Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer's diseaseAlexander Drzezga
Department of Nuclear Medicine, Technische Universitat, Munchen, Ismaninger Str 22, D 81675 Munich, Germany
Neuroimage 39:619-33. 2008.... - 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairmentClifford R Jack
Department of Diagnostic Radiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
Brain 131:665-80. 2008..PiB and MRI provided complementary information such that clinical diagnostic classification using both methods was superior to using either in isolation... - Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memoryRandy L Buckner
Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63105, USA
J Neurosci 25:7709-17. 2005..These cortical regions may be part of a network with the medial temporal lobe whose disruption contributes to memory impairment... - Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's diseaseYun Zhou
The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
Neuroimage 36:298-312. 2007..For pixel-wise quantification, due to the high noise level of pixel kinetics, the parametric images generated by RTM with conventional linear or nonlinear regression may be too noisy for use in clinical studies... - Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic miceRobert P Brendza
Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Clin Invest 115:428-33. 2005..This analysis suggests that ongoing axonal and dendritic damage is secondary to Abeta and is, in part, rapidly reversible... - Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer's disease with Pittsburgh Compound BCyrus A Raji
Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2593, United States
J Neurosci Methods 172:277-82. 2008..02, p=0.01) and anterior ventral striatum [t(9)=2.37, p=0.04] in AD. No group differences (AD versus MCI) were detected in laterality [F (1, 15)=0.15, p=0.7] or asymmetry [F (1, 15)=0.7, p=0.42]... - Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humansAnne M Fagan
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Ann Neurol 59:512-9. 2006..This decrease may reflect plaques acting as an Abeta(42) "sink," hindering transport of soluble Abeta(42) between brain and CSF. We investigated this hypothesis... - Development of a PET/SPECT agent for amyloid imaging in Alzheimer's diseaseYanming Wang
Department of Medicinal Chemistry and Pharmacology, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
J Mol Neurosci 24:55-62. 2004..These results suggest that the new radioiodinated benzothiazole ligand might be useful as a surrogate marker for the in vivo quantitation of amyloid deposition in human brain for use with either PET or SPECT... - Targeting prion amyloid deposits in vivoMarcin Sadowski
Department of Neurology, New York University School of Medicine, New York, New York 10016, USA
J Neuropathol Exp Neurol 63:775-84. 2004..These results suggest that methoxy-X04 or similar derivatives could be used as PET imaging agents to improve the diagnosis of human prion diseases associated with amyloid deposition... - PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDSSriram Venneti
Department of Neurobiology, University of Pittsburgh School of Medicine, Pennsylvania, USA
J Clin Invest 113:981-9. 2004....
Research Grants
- Amyloid Imaging Agents for Positron Emission TomographyChester Mathis; Fiscal Year: 2004..abstract_text> ..
- Amyloid Imaging Agents for Position Emission TomographyChester Mathis; Fiscal Year: 2007....
- Amyloid Imaging Agents for Position Emission TomographyChester Mathis; Fiscal Year: 2009....
- Amyloid Imaging Agents for Position Emission TomographyChester A Mathis; Fiscal Year: 2010....