Chester A Mathis

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain
    Chester A Mathis
    PET Facility, Department of Radiology, University of Pittsburgh, PA 15213, USA
    Bioorg Med Chem Lett 12:295-8. 2002
  2. ncbi request reprint Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents
    Chester A Mathis
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Med Chem 46:2740-54. 2003
  3. ncbi request reprint Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635
    Ursula F Bailer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:1032-41. 2005
  4. pmc Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease
    Clayton A Wiley
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Arch Neurol 66:60-7. 2009
  5. ncbi request reprint Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease
    Scott K Ziolko
    Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Rm B 938, PA 15213, USA
    Neuroimage 33:94-102. 2006
  6. ncbi request reprint Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Neuropathol Exp Neurol 61:797-805. 2002
  7. ncbi request reprint Exaggerated 5-HT1A but normal 5-HT2A receptor activity in individuals ill with anorexia nervosa
    Ursula F Bailer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, Pittsburgh, University of Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 61:1090-9. 2007
  8. pmc Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain 131:1630-45. 2008
  9. doi request reprint No effect of dopamine depletion on the binding of the high-affinity D 2/3 radiotracer [11C]FLB 457 in the human cortex
    W Gordon Frankle
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 64:879-85. 2010
  10. ncbi request reprint Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis
    Brian J Lopresti
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Nucl Med 46:1959-72. 2005

Collaborators

Detail Information

Publications91

  1. ncbi request reprint A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain
    Chester A Mathis
    PET Facility, Department of Radiology, University of Pittsburgh, PA 15213, USA
    Bioorg Med Chem Lett 12:295-8. 2002
    ..Amyloid deposits were imaged with multiphoton microscopy in the brains of living transgenic mice following the systemic injection of unlabeled 6. [(11)C]6 is a promising amyloid imaging agent for Alzheimer's disease...
  2. ncbi request reprint Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents
    Chester A Mathis
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Med Chem 46:2740-54. 2003
    ..The encouraging in vitro and in vivo properties of [(11)C]6-OH-BTA-1 support the choice of this derivative for further evaluation in human subject studies of brain Abeta deposition...
  3. ncbi request reprint Altered brain serotonin 5-HT1A receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [carbonyl11C]WAY-100635
    Ursula F Bailer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:1032-41. 2005
    ..Previous studies have shown that women with anorexia nervosa (AN), when ill and after recovery, have alterations of serotonin (5-HT) neuronal activity and core eating disorder symptoms, such as anxiety...
  4. pmc Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease
    Clayton A Wiley
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Arch Neurol 66:60-7. 2009
    ..Because postmortem histopathological analyses are limited to single end-stage assessment, the time course and nature of this relationship are not well understood...
  5. ncbi request reprint Evaluation of voxel-based methods for the statistical analysis of PIB PET amyloid imaging studies in Alzheimer's disease
    Scott K Ziolko
    Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop Street, Rm B 938, PA 15213, USA
    Neuroimage 33:94-102. 2006
    ..These results indicate that voxel-based methods will be useful for future larger longitudinal studies of amyloid deposition that could improve AD diagnosis and anti-amyloid therapy assessment...
  6. ncbi request reprint Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Neuropathol Exp Neurol 61:797-805. 2002
    ....
  7. ncbi request reprint Exaggerated 5-HT1A but normal 5-HT2A receptor activity in individuals ill with anorexia nervosa
    Ursula F Bailer
    Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, Pittsburgh, University of Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 61:1090-9. 2007
    ..Because little is known about 5-HT receptor function in AN, positron emission tomography (PET) imaging with 5-HT receptor-specific radioligands was used to characterize 5-HT1A and 5-HT2A receptors...
  8. pmc Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain 131:1630-45. 2008
    ..The strong direct correlation of in vivo PiB retention with region-matched quantitative analyses of Abeta plaques in the same subject supports the validity of PiB-PET imaging as a method for in vivo evaluation of Abeta plaque burden...
  9. doi request reprint No effect of dopamine depletion on the binding of the high-affinity D 2/3 radiotracer [11C]FLB 457 in the human cortex
    W Gordon Frankle
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 64:879-85. 2010
    ..In contrast to the measurement of DA release, the combination of low D(2) receptor density and low basal DA levels in the cortex greatly reduce the power to detect alterations in [(11)C]FLB 457 binding secondary to DA depletion...
  10. ncbi request reprint Simplified quantification of Pittsburgh Compound B amyloid imaging PET studies: a comparative analysis
    Brian J Lopresti
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Nucl Med 46:1959-72. 2005
    ..This work reports on simplified methods of analysis for human PIB imaging...
  11. pmc The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Exp Neurol 207:118-27. 2007
    ....
  12. pmc PK11195 labels activated microglia in Alzheimer's disease and in vivo in a mouse model using PET
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neurobiol Aging 30:1217-26. 2009
    ....
  13. pmc Imaging Alzheimer pathology in late-life depression with PET and Pittsburgh Compound-B
    Meryl A Butters
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Alzheimer Dis Assoc Disord 22:261-8. 2008
    ..Our findings are consistent with and supportive of the hypothesis that depression may herald the development of AD in some individuals...
  14. pmc Evaluation of dopamine D₂/₃ specific binding in the cerebellum for the positron emission tomography radiotracer [¹¹C]FLB 457: implications for measuring cortical dopamine release
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 65:991-7. 2011
    ..Nevertheless, caution is advised when using reference tissue methods that rely solely on the cerebellum signal as an input function to quantify [¹¹C]FLB 457 BP(ND)...
  15. ncbi request reprint Kinetic modeling of amyloid binding in humans using PET imaging and Pittsburgh Compound-B
    Julie C Price
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Cereb Blood Flow Metab 25:1528-47. 2005
    ..This study also showed that it is feasible to perform quantitative PIB PET imaging studies that are needed to validate simpler methods for routine use across the AD disease spectrum...
  16. ncbi request reprint Serotonin transporter binding after recovery from eating disorders
    Ursula F Bailer
    Western Psychiatric Institute and Clinic, University of Pittsburgh, Iroquois Building, Suite 600, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 195:315-24. 2007
    ..Several lines of evidence suggest that altered serotonin (5-HT) function persists after recovery from anorexia nervosa (AN) and bulimia nervosa (BN)...
  17. pmc A comparative evaluation of the dopamine D(2/3) agonist radiotracer [11C](-)-N-propyl-norapomorphine and antagonist [11C]raclopride to measure amphetamine-induced dopamine release in the human striatum
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh Medical Center Presbyterian, PET Facility, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Pharmacol Exp Ther 333:533-9. 2010
    ..Nevertheless, these data add to the growing literature that suggests D(2/3) agonist radiotracers are more vulnerable to endogenous competition by dopamine than existing D(2/3) antagonist radiotracers...
  18. pmc Basal cerebral metabolism may modulate the cognitive effects of Abeta in mild cognitive impairment: an example of brain reserve
    Ann D Cohen
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 29:14770-8. 2009
    ....
  19. pmc Frequent amyloid deposition without significant cognitive impairment among the elderly
    Howard Jay Aizenstein
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Arch Neurol 65:1509-17. 2008
    ....
  20. ncbi request reprint Cognitive correlates of alterations in acetylcholinesterase in Alzheimer's disease
    Nicolaas I Bohnen
    Department of Neurology, University of Pittsburgh Medical School, Liliane S Kaufmann Building, Suite 811, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA
    Neurosci Lett 380:127-32. 2005
    ..Similar findings were present when the analysis was limited to the temporal cortex. Cortical AChE activity is more robustly associated with functions of attention and working memory compared to performance on primary memory tests in AD...
  21. ncbi request reprint Binding of the positron emission tomography tracer Pittsburgh compound-B reflects the amount of amyloid-beta in Alzheimer's disease brain but not in transgenic mouse brain
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 25:10598-606. 2005
    ....
  22. doi request reprint Positron emission tomography imaging of amphetamine-induced dopamine release in the human cortex: a comparative evaluation of the high affinity dopamine D2/3 radiotracers [11C]FLB 457 and [11C]fallypride
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 63:447-61. 2009
    ..These findings suggest that [(11)C]FLB 457 is superior to [(11)C]fallypride for measurement of changes in cortical synaptic dopamine...
  23. pmc In vivo assessment of amyloid-β deposition in nondemented very elderly subjects
    Chester A Mathis
    Department of Radiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Ann Neurol 73:751-61. 2013
    ....
  24. ncbi request reprint Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography
    William E Klunk
    Laboratory of Molecular Neuropharmacology, Department of Psychiatry, University of Pittsburgh School of Medicine, 705 Parran Hall, Pittsburgh, PA 15213, USA
    Neuroimaging Clin N Am 13:781-9, ix. 2003
    ..The capability to use positron emission tomography and selective markers for amyloid protein deposition promises to substantially alter the way we diagnosis and manage patients who have AD...
  25. pmc [11C]flumazenil binding is increased in a dose-dependent manner with tiagabine-induced elevations in GABA levels
    W Gordon Frankle
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 7:e32443. 2012
    ..67, p = 0.05) measured via EEG during a cognitive control task. These data provide a replication of our previous study demonstrating the ability to measure in vivo, with PET, acute shifts in extracellular GABA...
  26. pmc Positron emission tomography imaging of dopamine D₂/₃ receptors in the human cortex with [¹¹C]FLB 457: reproducibility studies
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 65:35-40. 2011
    ..These data support the further validation of [¹¹C]FLB 457 as a tool to measure amphetamine-induced dopamine release in the human cortex...
  27. pmc Human biodistribution and dosimetry of the D2/3 agonist 11C-N-propylnorapomorphine (11C-NPA) determined from PET
    Charles M Laymon
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Nucl Med 50:814-7. 2009
    ..We measured the whole-body distribution of intravenously injected (11)C-N-propylnorapomorphine ((11)C-NPA), a dopamine agonist PET tracer, in human subjects and determined the resulting absorbed radiation doses...
  28. pmc Inter-rater reliability of manual and automated region-of-interest delineation for PiB PET
    Bedda L Rosario
    Department of Radiology, University of Pittsburgh School of Medicine, Presbyterian University Hospital, B 938, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Neuroimage 55:933-41. 2011
    ....
  29. ncbi request reprint Effects of lipophilicity on the affinity and nonspecific binding of iodinated benzothiazole derivatives
    Yanming Wang
    P E T Facility, Department of Radiology, Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Mol Neurosci 20:255-60. 2003
    ..These results provide important SAR information to guide the development of novel amyloid-binding agents and provide further insights into the molecular interaction between 2-aryl benzothiazole ligands and Abeta fibrils...
  30. pmc Classification of amyloid-positivity in controls: comparison of visual read and quantitative approaches
    Ann D Cohen
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuroimage 71:207-15. 2013
    ..IO was developed using full-dynamic atrophy-corrected PiB PET data obtained from a group of control subjects with a fairly distinct separation between PiB-positive [PiB(+)] and PiB-negative [PiB(-)] subjects...
  31. pmc Cognitive trajectories associated with β-amyloid deposition in the oldest-old without dementia
    Beth E Snitz
    Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
    Neurology 80:1378-84. 2013
    ..To determine whether a high prevalence (55%) of Aβ deposition in a cohort of individuals remaining dementia-free into their 9th and 10th decades is associated with cognitive decline prior to imaging...
  32. pmc Amyloid deposition begins in the striatum of presenilin-1 mutation carriers from two unrelated pedigrees
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 27:6174-84. 2007
    ..The early, focal striatal amyloid deposition observed in these PS1 mutation carriers is often is not associated with clinical symptoms...
  33. pmc Tiagabine increases [11C]flumazenil binding in cortical brain regions in healthy control subjects
    W Gordon Frankle
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 34:624-33. 2009
    ....
  34. ncbi request reprint X-34 labeling of abnormal protein aggregates during the progression of Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology and Psychiatry, University of Pittsburgh, Pennsylvania 15213, USA
    Methods Enzymol 412:123-44. 2006
    ....
  35. pmc Consideration of optimal time window for Pittsburgh compound B PET summed uptake measurements
    REBECCA L MCNAMEE
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Nucl Med 50:348-55. 2009
    ..In this work, regional PiB SUVRs were examined across 9 time windows to select the window that provided the best trade-offs between bias, correlation, and effective contrast...
  36. ncbi request reprint The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component
    William E Klunk
    Laboratory of Molecular Neuropharmacology, Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 23:2086-92. 2003
    ..Finally, BTA-1 did not appear to bind significantly to common neuroreceptors or transporter sites. These data suggest that the binding of BTA-1 to AD brain is dominated by a specific interaction with Abeta amyloid deposits...
  37. ncbi request reprint Synthesis and evaluation of 2-(3'-iodo-4'-aminophenyl)-6-hydroxybenzothiazole for in vivo quantitation of amyloid deposits in Alzheimer's disease
    Yanming Wang
    PET Facility, Department of Radiology, School of Medicine, University of Pittsburgh, PA 15213, USA
    J Mol Neurosci 19:11-6. 2002
    ..43+/-0.62%ID/g detected in the whole brain at 2 min post i.v. injection. At 30 min, the radioactivity concentration decreased to 0.40+/-0.05%ID/g, indicating good clearance in the absence of amyloid deposits in the brain...
  38. pmc Imaging of dopamine D2/3 agonist binding in cocaine dependence: a [11C]NPA positron emission tomography study
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 65:1344-9. 2011
    ....
  39. ncbi request reprint Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B
    William E Klunk
    Department of Psychiatry, PET Facility, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Ann Neurol 55:306-19. 2004
    ..This relationship was most robust in the parietal cortex (r = -0.72; p = 0.0001). The results suggest that PET imaging with the novel tracer, PIB, can provide quantitative information on amyloid deposits in living subjects...
  40. pmc Amyloid imaging in mild cognitive impairment subtypes
    David A Wolk
    Alzheimer s Disease Research Center, University of Pittsburgh, Pittsburgh, PA 19104, USA
    Ann Neurol 65:557-68. 2009
    ....
  41. doi request reprint Human biodistribution and dosimetry of the PET radioligand [¹¹C]flumazenil (FMZ)
    Charles M Laymon
    Department of Radiology, UPMC Presbyterian Hospital, University of Pittsburgh, Room B 938, 200 Lothrop St, Pittsburgh, PA 15213, USA
    Mol Imaging Biol 14:115-22. 2012
    ..We measure the whole-body distribution of IV injected [¹¹C]Flumazenil (FMZ) as a function of time in adult subjects and determine the absorbed radiation doses...
  42. pmc In vivo evidence for low striatal vesicular monoamine transporter 2 (VMAT2) availability in cocaine abusers
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, USA
    Am J Psychiatry 169:55-63. 2012
    ....
  43. ncbi request reprint A comparison of the high-affinity peripheral benzodiazepine receptor ligands DAA1106 and (R)-PK11195 in rat models of neuroinflammation: implications for PET imaging of microglial activation
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Neurochem 102:2118-31. 2007
    ....
  44. pmc Grooved pegboard test as a biomarker of nigrostriatal denervation in Parkinson's disease
    Nicolaas I Bohnen
    Department of Radiology, University of Michigan, Ann Arbor, MI 48109 0028, USA
    Neurosci Lett 424:185-9. 2007
    ..These findings indicate that there is both a statistical "floor" and "ceiling" effect for the most affected striatal and body sides that must be considered when employing imaging as an outcome measure in clinical trials in PD...
  45. ncbi request reprint Regional cerebral blood flow after recovery from anorexia or bulimia nervosa
    Guido K Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Int J Eat Disord 40:488-92. 2007
    ..Abnormalities of regional cerebral blood flow (rCBF) have been found in individuals who are ill with anorexia (AN) or bulimia nervosa (BN). Little is known about whether rCBF normalizes after recovery from AN and BN...
  46. ncbi request reprint Measurement of 5-HT1A receptor binding in depressed adults before and after antidepressant drug treatment using positron emission tomography and [11C]WAY-100635
    Eydie L Moses-Kolko
    Departments of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Synapse 61:523-30. 2007
    ..To assess effects of chronic antidepressant drug treatment on serotonin type-1A receptor (5-HT(1A)R) binding potential (BP) in major depressive disorder...
  47. pmc Longitudinal in vivo positron emission tomography imaging of infected and activated brain macrophages in a macaque model of human immunodeficiency virus encephalitis correlates with central and peripheral markers of encephalitis and areas of synaptic dege
    Sriram Venneti
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Pathol 172:1603-16. 2008
    ..A combination of PET imaging and the assessment of these peripheral immune parameters may facilitate longitudinal assessment of lentiviral encephalitis in living patients as well as evaluation of therapeutic efficacies...
  48. ncbi request reprint Serotonin alterations in anorexia and bulimia nervosa: new insights from imaging studies
    Walter H Kaye
    University of Pittsburgh, School of Medicine, Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, United States
    Physiol Behav 85:73-81. 2005
    ..Alterations of these circuits may affect mood and impulse control as well as the motivating and hedonic aspects of feeding behavior. Such imaging studies may offer insights into new pharmacology and psychotherapy approaches...
  49. pmc Using Pittsburgh Compound B for in vivo PET imaging of fibrillar amyloid-beta
    Ann D Cohen
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Adv Pharmacol 64:27-81. 2012
    ..Here, we will discuss the application of one of the most broadly studied and widely used Aβ imaging agents, Pittsburgh Compound-B (PiB)...
  50. pmc Early AD pathology in a [C-11]PiB-negative case: a PiB-amyloid imaging, biochemical, and immunohistochemical study
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, 200 Lothrop Street BST S521, Pittsburgh, PA 15213 USA
    Acta Neuropathol 123:433-47. 2012
    ..Studies in greater numbers of [C-11]PiB PET autopsy cases are needed to define the Aβ concentration and [H-3]PiB binding levels required to produce a positive [C-11]PiB PET signal...
  51. pmc Positron emission tomography imaging of D(2/3) agonist binding in healthy human subjects with the radiotracer [(11)C]-N-propyl-norapomorphine: preliminary evaluation and reproducibility studies
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 63:574-84. 2009
    ..The aim of the present study was to define the optimal analytic method to derive accurate and reliable D(2/3) receptor parameters with [(11)C]NPA...
  52. ncbi request reprint Imaging of amyloid burden and distribution in cerebral amyloid angiopathy
    Keith A Johnson
    Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    Ann Neurol 62:229-34. 2007
    ....
  53. ncbi request reprint Serotonin 1A receptor binding and treatment response in late-life depression
    Carolyn Cidis Meltzer
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA, USA
    Neuropsychopharmacology 29:2258-65. 2004
    ..Further, this work indicates that dysfunction in autoreceptor activity may play a central role in the mechanisms underlying treatment response to selective serotonin reuptake inhibitors in late-life depression...
  54. pmc Preventive immunization of aged and juvenile non-human primates to β-amyloid
    Julia Kofler
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Neuroinflammation 9:84. 2012
    ....
  55. pmc Imaging brain amyloid in nondemented young adults with Down syndrome using Pittsburgh compound B
    Benjamin L Handen
    Department of Psychiatry, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Alzheimers Dement 8:496-501. 2012
    ..These results demonstrate the feasibility of conducting PiB positron emission tomography scanning in this special population, and suggest a link between Aβ overproduction and early striatal deposition of fibrillar Aβ...
  56. ncbi request reprint MR atlas of the baboon brain for functional neuroimaging
    Phil J Greer
    University of Pittsburgh PET Facility, Pittsburgh, PA 15213 2582, USA
    Brain Res Bull 58:429-38. 2002
    ..Overall, the digital MR-based atlas allowed for automatic co-registration, proved useful across a range of PET Studies, and is accessible electronically via the Internet...
  57. ncbi request reprint Imaging technology for neurodegenerative diseases: progress toward detection of specific pathologies
    Chester A Mathis
    Department of Neurology, University of Pittsburgh and Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Arch Neurol 62:196-200. 2005
    ....
  58. ncbi request reprint Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairment
    Clayton A Wiley
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurovirol 12:262-71. 2006
    ....
  59. ncbi request reprint Positron emission tomography radiochemistry
    N Scott Mason
    Positron Emission Tomography Facility, Department of Radiology, University of Pittsburgh, B 938, UPMC Presbyterian, 200 Lothrop Street, Pittsburgh, PA 15213 2582, USA
    Neuroimaging Clin N Am 13:671-87. 2003
    ..Although the number of PET radiotracers synthesized is in the hundreds [6], much work remains to develop specific and useful PET radiotracers for a host of new and exciting noninvasive imaging applications...
  60. pmc The future of amyloid-beta imaging: a tale of radionuclides and tracer proliferation
    William E Klunk
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Curr Opin Neurol 21:683-7. 2008
    ....
  61. pmc Whatever happened to Pittsburgh Compound-A?
    William E Klunk
    Department of Psychiatry and Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Alzheimer Dis Assoc Disord 22:198-203. 2008
  62. pmc Impact of amyloid imaging on drug development in Alzheimer's disease
    Chester A Mathis
    Department of Radiology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Nucl Med Biol 34:809-22. 2007
    ....
  63. ncbi request reprint Selective hyposmia and nigrostriatal dopaminergic denervation in Parkinson's disease
    Nicolaas I Bohnen
    Dept of Neurology, University of Pittsburgh, Pittsburgh, PA, USA
    J Neurol 254:84-90. 2007
    ..Assessment of selective olfactory deficits may be used as a simplified olfactory screening test in the evaluation of subjects with possible PD...
  64. pmc Synthesis and beta-amyloid binding properties of rhenium 2-phenylbenzothiazoles
    Kuo Shyan Lin
    Department of Radiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Bioorg Med Chem Lett 19:2258-62. 2009
    ....
  65. pmc Development of positron emission tomography β-amyloid plaque imaging agents
    Chester A Mathis
    Department of Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Semin Nucl Med 42:423-32. 2012
    ..It is likely that the full clinical impact of these imaging agents will be realized by identifying presymptomatic subjects who would benefit from early drug treatments with future disease-modifying AD therapeutics...
  66. ncbi request reprint Cortical cholinergic function is more severely affected in parkinsonian dementia than in Alzheimer disease: an in vivo positron emission tomographic study
    Nicolaas I Bohnen
    Departments of Neurology and Radiology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Neurol 60:1745-8. 2003
    ..We hypothesized that patients with PDem would have cholinergic deficits that were similar to or greater than those of patients with AD...
  67. ncbi request reprint Altered 5-HT(2A) receptor binding after recovery from bulimia-type anorexia nervosa: relationships to harm avoidance and drive for thinness
    Ursula F Bailer
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 29:1143-55. 2004
    ..It is possible that subgenual cingulate findings are not specific for AN-BN, but may be related to the high incidence of lifetime major depressive disorder diagnosis in these subjects...
  68. ncbi request reprint Two-year follow-up of amyloid deposition in patients with Alzheimer's disease
    William E Klunk
    University of Pittsburgh Medical School Pittsburgh, MA, USA
    Brain 129:2805-7. 2006
  69. ncbi request reprint Evidence of increased serotonin-1A receptor binding in type 2 diabetes: a positron emission tomography study
    Julie C Price
    PET Facility, Department of Radiology, University of Pittsburgh School of Medicine, 200 Lothrop St, Rm B938, Pittsburgh, PA 15213, USA
    Brain Res 927:97-103. 2002
    ..02). These findings support previous studies that suggest serotonergic underpinnings to the neurobiology of diabetes and have shown diabetes-induced neurological changes in hippocampus...
  70. ncbi request reprint Sequential H(2)(15)O PET studies in baboons: before and after amphetamine
    Julie C Price
    Department of Radiology, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Nucl Med 43:1090-100. 2002
    ..A common assumption in bolus injection PET studies of this type is that cerebral blood flow (CBF) does not vary during the scan. The goal of this work was to examine the effect of AMPH administration on sequential PET measures of CBF...
  71. ncbi request reprint Distribution of 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) uracil in mice bearing colorectal cancer xenografts: rationale for therapeutic use and as a positron emission tomography probe for thymidylate synthase
    Julie L Eiseman
    Molecular Therapeutics Drug Discovery Program, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15213 1863, USA
    Clin Cancer Res 10:6669-76. 2004
    ..These studies were designed to evaluate FAU as a potential therapeutic and diagnostic probe...
  72. ncbi request reprint Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans
    Anne M Fagan
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 59:512-9. 2006
    ..This decrease may reflect plaques acting as an Abeta(42) "sink," hindering transport of soluble Abeta(42) between brain and CSF. We investigated this hypothesis...
  73. pmc Imaging of CNS myelin by positron-emission tomography
    Bruno Stankoff
    Institut National de la Sante et de la Recherche Medicale, U711, Hopital de la Salpetriere, F 75013 Paris, France
    Proc Natl Acad Sci U S A 103:9304-9. 2006
    ..Our results provide a perspective for developing a brain myelin imaging technique by positron-emission tomography...
  74. pmc 11C PiB and structural MRI provide complementary information in imaging of Alzheimer's disease and amnestic mild cognitive impairment
    Clifford R Jack
    Department of Diagnostic Radiology, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Brain 131:665-80. 2008
    ..PiB and MRI provided complementary information such that clinical diagnostic classification using both methods was superior to using either in isolation...
  75. ncbi request reprint Targeting proteins in vivo: in vitro guidelines
    William C Eckelman
    Nucl Med Biol 33:161-4. 2006
  76. pmc Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice
    Robert P Brendza
    Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:428-33. 2005
    ..This analysis suggests that ongoing axonal and dendritic damage is secondary to Abeta and is, in part, rapidly reversible...
  77. ncbi request reprint Imaging of amyloid plaques and cerebral glucose metabolism in semantic dementia and Alzheimer's disease
    Alexander Drzezga
    Department of Nuclear Medicine, Technische Universitat, Munchen, Ismaninger Str 22, D 81675 Munich, Germany
    Neuroimage 39:619-33. 2008
    ....
  78. ncbi request reprint Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory
    Randy L Buckner
    Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63105, USA
    J Neurosci 25:7709-17. 2005
    ..These cortical regions may be part of a network with the medial temporal lobe whose disruption contributes to memory impairment...
  79. ncbi request reprint Imaging amyloid-beta deposits in vivo
    Brian J Bacskai
    Alzheimer Research Unit, Massachusetts General Hospital, Charlestown 02129, USA
    J Cereb Blood Flow Metab 22:1035-41. 2002
    ..This review describes the progress in developing reagents suitable for in vivo imaging of senile plaques...
  80. pmc Characterizing regional correlation, laterality and symmetry of amyloid deposition in mild cognitive impairment and Alzheimer's disease with Pittsburgh Compound B
    Cyrus A Raji
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2593, United States
    J Neurosci Methods 172:277-82. 2008
    ..02, p=0.01) and anterior ventral striatum [t(9)=2.37, p=0.04] in AD. No group differences (AD versus MCI) were detected in laterality [F (1, 15)=0.15, p=0.7] or asymmetry [F (1, 15)=0.7, p=0.42]...
  81. ncbi request reprint Development of a PET/SPECT agent for amyloid imaging in Alzheimer's disease
    Yanming Wang
    Department of Medicinal Chemistry and Pharmacology, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA
    J Mol Neurosci 24:55-62. 2004
    ..These results suggest that the new radioiodinated benzothiazole ligand might be useful as a surrogate marker for the in vivo quantitation of amyloid deposition in human brain for use with either PET or SPECT...
  82. ncbi request reprint Targeting prion amyloid deposits in vivo
    Marcin Sadowski
    Department of Neurology, New York University School of Medicine, New York, New York 10016, USA
    J Neuropathol Exp Neurol 63:775-84. 2004
    ..These results suggest that methoxy-X04 or similar derivatives could be used as PET imaging agents to improve the diagnosis of human prion diseases associated with amyloid deposition...
  83. ncbi request reprint Discussion of targeting proteins in vivo: in vitro guidelines
    William C Eckelman
    Nucl Med Biol 33:449-51. 2006
  84. pmc Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance
    Tristan Bolmont
    Department of Cellular Neurology, Hertie Institute for Clinical Brain Research, University of Tubingen, D 72076 Tubingen, Germany
    J Neurosci 28:4283-92. 2008
    ..These results indicate a role for microglia in plaque maintenance and provide a model with multiple targets for therapeutic intervention...
  85. ncbi request reprint Increased dopamine D2/D3 receptor binding after recovery from anorexia nervosa measured by positron emission tomography and [11c]raclopride
    Guido K Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, School of Medicine, University of California San Diego, California, USA
    Biol Psychiatry 58:908-12. 2005
    ..Several lines of evidence support the possibility that disturbances of dopamine (DA) function could contribute to alterations of weight, feeding, motor activity, and reward in anorexia nervosa (AN)...
  86. pmc Using a reference tissue model with spatial constraint to quantify [11C]Pittsburgh compound B PET for early diagnosis of Alzheimer's disease
    Yun Zhou
    The Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD 21287 0807, USA
    Neuroimage 36:298-312. 2007
    ..For pixel-wise quantification, due to the high noise level of pixel kinetics, the parametric images generated by RTM with conventional linear or nonlinear regression may be too noisy for use in clinical studies...
  87. pmc Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice
    Brian J Bacskai
    Department of Neurology Alzheimer s Disease Research Laboratory, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 100:12462-7. 2003
    ..WT mice showed rapid brain entry and clearance of PIB without any binding. These results demonstrate that the compound PIB has the properties required for a good amyloid-imaging agent in humans with or at risk for AD...
  88. ncbi request reprint Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report
    Brian J Bacskai
    MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Charlestown, MA 02129, USA
    Arch Neurol 64:431-4. 2007
    ..Imaging revealed marked region specific binding of PiB and abnormal fluorodeoxyglucose uptake. Intervention Autopsy was performed 3 months after the PiB scan...
  89. ncbi request reprint Beta-amyloid imaging and memory in non-demented individuals: evidence for preclinical Alzheimer's disease
    Kerryn E Pike
    School of Psychology, Psychiatry and Psychological Medicine, Monash University, Melbourne, Australia
    Brain 130:2837-44. 2007
    ..The data also suggests that early intervention trials for AD targeted to non-demented individuals with cerebral Abeta deposition are warranted...
  90. pmc Longitudinal cerebral blood flow and amyloid deposition: an emerging pattern?
    Jitka Sojkova
    National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    J Nucl Med 49:1465-71. 2008
    ....
  91. pmc PET imaging of brain macrophages using the peripheral benzodiazepine receptor in a macaque model of neuroAIDS
    Sriram Venneti
    Department of Neurobiology, University of Pittsburgh School of Medicine, Pennsylvania, USA
    J Clin Invest 113:981-9. 2004
    ....