Carol Mathews

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Familiality of Tourette syndrome, obsessive-compulsive disorder, and attention-deficit/hyperactivity disorder: heritability analysis in a large sib-pair sample
    Carol A Mathews
    Department of Psychiatry, University of California San Francisco, 401 Parnassus Ave, San Francisco, CA 94143 0984, USA
    J Am Acad Child Adolesc Psychiatry 50:46-54. 2011
  2. pmc Genome-wide linkage analysis of obsessive-compulsive disorder implicates chromosome 1p36
    Carol A Mathews
    Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143 0984, USA
    Biol Psychiatry 72:629-36. 2012
  3. pmc Error-related negativity in individuals with obsessive-compulsive symptoms: toward an understanding of hoarding behaviors
    Carol A Mathews
    Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA
    Biol Psychol 89:487-94. 2012
  4. doi request reprint Evidence for a heritable unidimensional symptom factor underlying obsessionality
    Carol A Mathews
    Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 0984, USA
    Am J Med Genet B Neuropsychiatr Genet 147:676-85. 2008
  5. ncbi request reprint Childhood trauma and obsessive-compulsive symptoms
    Carol A Mathews
    Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 0894, USA
    Depress Anxiety 25:742-51. 2008
  6. ncbi request reprint Heritability and clinical features of multigenerational families with obsessive-compulsive disorder and hoarding
    Carol A Mathews
    Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 0984, USA
    Am J Med Genet B Neuropsychiatr Genet 144:174-82. 2007
  7. ncbi request reprint Association between maternal smoking and increased symptom severity in Tourette's syndrome
    Carol A Mathews
    Department of Psychiatry, University of California San Diego, La Jolla, CA, and the Department of Psychiatry, North Shore University Hospital New York University School of Medicine, Manhasset, NY, USA
    Am J Psychiatry 163:1066-73. 2006
  8. ncbi request reprint Comorbidity of bipolar disorder and substance abuse in Costa Rica: pedigree- and population-based studies
    Michael A Escamilla
    Department of Psychiatry, 7792, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Affect Disord 71:71-83. 2002
  9. pmc Genomewide linkage disequilibrium mapping of severe bipolar disorder in a population isolate
    Roel A Ophoff
    Neurogenetics Laboratory, University of California, San Francisco, CA, USA
    Am J Hum Genet 71:565-74. 2002
  10. doi request reprint Cognitive functioning in individuals with severe compulsive hoarding behaviors and late life depression
    R Scott Mackin
    Department of Psychiatry, University of California, San Francisco, USA
    Int J Geriatr Psychiatry 26:314-21. 2011

Research Grants

Collaborators

Detail Information

Publications22

  1. pmc Familiality of Tourette syndrome, obsessive-compulsive disorder, and attention-deficit/hyperactivity disorder: heritability analysis in a large sib-pair sample
    Carol A Mathews
    Department of Psychiatry, University of California San Francisco, 401 Parnassus Ave, San Francisco, CA 94143 0984, USA
    J Am Acad Child Adolesc Psychiatry 50:46-54. 2011
    ..However, the genetic relations between these disorders have not been clearly elucidated. This study examined the familial relations among TS, OCD, and ADHD in a large sample of TS families...
  2. pmc Genome-wide linkage analysis of obsessive-compulsive disorder implicates chromosome 1p36
    Carol A Mathews
    Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143 0984, USA
    Biol Psychiatry 72:629-36. 2012
    ..However, the genetic causes of OCD are largely unknown, despite the identification of several promising candidate genes and linkage regions...
  3. pmc Error-related negativity in individuals with obsessive-compulsive symptoms: toward an understanding of hoarding behaviors
    Carol A Mathews
    Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA
    Biol Psychol 89:487-94. 2012
    ..These results suggest that abnormal ERN in OCD/S is task-dependent, and that OCD/S+hoarding show different ERN activity from OCD/S-hoarding perhaps suggesting different pathophysiological mechanisms of error monitoring...
  4. doi request reprint Evidence for a heritable unidimensional symptom factor underlying obsessionality
    Carol A Mathews
    Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 0984, USA
    Am J Med Genet B Neuropsychiatr Genet 147:676-85. 2008
    ..This component, which is heritable, accounts for the majority of the variation of the more traditionally derived symptom factors in our sample, and is composed of OCS that are not specific to any of the symptom subgroups...
  5. ncbi request reprint Childhood trauma and obsessive-compulsive symptoms
    Carol A Mathews
    Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 0894, USA
    Depress Anxiety 25:742-51. 2008
    ....
  6. ncbi request reprint Heritability and clinical features of multigenerational families with obsessive-compulsive disorder and hoarding
    Carol A Mathews
    Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 0984, USA
    Am J Med Genet B Neuropsychiatr Genet 144:174-82. 2007
    ..39 for hoarding. We found reasonable power to detect regions of interest (lod = 2) for OCD in these families, but will need to expand our family collection to have adequate power to detect regions of interest for hoarding...
  7. ncbi request reprint Association between maternal smoking and increased symptom severity in Tourette's syndrome
    Carol A Mathews
    Department of Psychiatry, University of California San Diego, La Jolla, CA, and the Department of Psychiatry, North Shore University Hospital New York University School of Medicine, Manhasset, NY, USA
    Am J Psychiatry 163:1066-73. 2006
    ....
  8. ncbi request reprint Comorbidity of bipolar disorder and substance abuse in Costa Rica: pedigree- and population-based studies
    Michael A Escamilla
    Department of Psychiatry, 7792, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Affect Disord 71:71-83. 2002
    ....
  9. pmc Genomewide linkage disequilibrium mapping of severe bipolar disorder in a population isolate
    Roel A Ophoff
    Neurogenetics Laboratory, University of California, San Francisco, CA, USA
    Am J Hum Genet 71:565-74. 2002
    ..This region could be important for severe psychiatric disorders, rather than for a specific phenotype...
  10. doi request reprint Cognitive functioning in individuals with severe compulsive hoarding behaviors and late life depression
    R Scott Mackin
    Department of Psychiatry, University of California, San Francisco, USA
    Int J Geriatr Psychiatry 26:314-21. 2011
    ....
  11. ncbi request reprint The structure of obsessionality among young adults
    Carol A Mathews
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0810, USA
    Depress Anxiety 20:77-85. 2004
    ....
  12. ncbi request reprint Results of a SNP genome screen in a large Costa Rican pedigree segregating for severe bipolar disorder
    Susan Service
    Center for Neurobehavioral Genetics, University of California, Los Angeles, 90095 1761, USA
    Am J Med Genet B Neuropsychiatr Genet 141:367-73. 2006
    ..The difficulties of analyzing genome wide SNP data for complex disorders in large, potentially informative, kindreds are discussed...
  13. ncbi request reprint Tic symptom profiles in subjects with Tourette Syndrome from two genetically isolated populations
    Carol A Mathews
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0810, USA
    Biol Psychiatry 61:292-300. 2007
    ..Tourette Syndrome (TS) has a complex etiology and wide variability in phenotypic expression. Identifying underlying symptom patterns may be useful for etiological and outcome studies of TS...
  14. ncbi request reprint Anxiety symptoms and perceived performance in medical students
    Uma Chandavarkar
    School of Medicine, University of California, San Diego, La Jolla, California, USA
    Depress Anxiety 24:103-11. 2007
    ..In contrast, other anxiety symptoms appear to be maladaptive responses to external stressors...
  15. ncbi request reprint A comparative study of obsessive-compulsive disorder in Costa Rica and the United States
    Denise A Chavira
    Department of Psychiatry, University of California San Diego, San Diego, California 92037, USA
    Depress Anxiety 25:609-19. 2008
    ..However some features of OCD, such as impairment, may be culturally influenced, leading to differences in prevalence rates and treatment utilization...
  16. ncbi request reprint Meta-analysis of the association between the catecholamine-O-methyl-transferase gene and obsessive-compulsive disorder
    Amin Azzam
    University of California, San Francisco, California 92093 0810, USA
    Am J Med Genet B Neuropsychiatr Genet 123:64-9. 2003
    ..Subgroup stratification based on gender generated no statistically significant associations. These results should be considered in any future work correlating the COMT gene with OCD...
  17. pmc ADHD prevalence and association with hoarding behaviors in childhood-onset OCD
    Brooke Sheppard
    Department of Psychiatry, University of California, San Francisco, 94143 0984, USA
    Depress Anxiety 27:667-74. 2010
    ....
  18. ncbi request reprint Genetic studies of neuropsychiatric disorders in Costa Rica: a model for the use of isolated populations
    Carol A Mathews
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0810, USA
    Psychiatr Genet 14:13-23. 2004
    ..In this paper we highlight the studies currently being conducted by our groups in the Central Valley of Costa Rica to illustrate the potential advantages of this population for genetic studies...
  19. ncbi request reprint Overrepresentation of rare variants in a specific ethnic group may confuse interpretation of association analyses
    Dianne Keen-Kim
    Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA
    Hum Mol Genet 15:3324-8. 2006
    ....
  20. pmc Latent class analysis of gilles de la tourette syndrome using comorbidities: clinical and genetic implications
    Marco A Grados
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Biol Psychiatry 64:219-25. 2008
    ..This study used latent class analyses (LCA) to identify GTS subphenotypes and assess characteristics and heritability of the classes...
  21. ncbi request reprint Sequence variants in SLITRK1 are associated with Tourette's syndrome
    Jesse F Abelson
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 310:317-20. 2005
    ..Wild-type SLITRK1, but not the frameshift mutant, enhanced dendritic growth in primary neuronal cultures. Collectively, these findings support the association of rare SLITRK1 sequence variants with TS...
  22. ncbi request reprint CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorder
    Annemieke J M H Verkerk
    Department of Clinical Genetics, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Genomics 82:1-9. 2003
    ....

Research Grants11

  1. Mentored Patient-Oriented Research Career Development Aw
    Carol Mathews; Fiscal Year: 2004
    ..An additional study sample will be collected to investigate the role of these variables on TS spectrum disorders. Clinical and genetic information will be analyzed and correlations explored using a variety of statistical measures. ..
  2. An Affected SibPair Study of ADHD in Costa Rica
    Carol Mathews; Fiscal Year: 2009
    ..Preliminary studies conducted in the CVCR show the feasibility of the sampling, diagnostic, and genotyping approaches described in this application. The sampling will be facilitated by ongoing collaborations established in the CVCR. ..