Research Topics
| Carol MathewsSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Familiality of Tourette syndrome, obsessive-compulsive disorder, and attention-deficit/hyperactivity disorder: heritability analysis in a large sib-pair sampleCarol A Mathews
Department of Psychiatry, University of California San Francisco, 401 Parnassus Ave, San Francisco, CA 94143 0984, USA
J Am Acad Child Adolesc Psychiatry 50:46-54. 2011..However, the genetic relations between these disorders have not been clearly elucidated. This study examined the familial relations among TS, OCD, and ADHD in a large sample of TS families...- Genome-wide linkage analysis of obsessive-compulsive disorder implicates chromosome 1p36Carol A Mathews
Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94143 0984, USA
Biol Psychiatry 72:629-36. 2012..However, the genetic causes of OCD are largely unknown, despite the identification of several promising candidate genes and linkage regions... - Error-related negativity in individuals with obsessive-compulsive symptoms: toward an understanding of hoarding behaviorsCarol A Mathews
Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA
Biol Psychol 89:487-94. 2012..These results suggest that abnormal ERN in OCD/S is task-dependent, and that OCD/S+hoarding show different ERN activity from OCD/S-hoarding perhaps suggesting different pathophysiological mechanisms of error monitoring... 
Evidence for a heritable unidimensional symptom factor underlying obsessionalityCarol A Mathews
Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 0984, USA
Am J Med Genet B Neuropsychiatr Genet 147:676-85. 2008..This component, which is heritable, accounts for the majority of the variation of the more traditionally derived symptom factors in our sample, and is composed of OCS that are not specific to any of the symptom subgroups...
Childhood trauma and obsessive-compulsive symptomsCarol A Mathews
Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 0894, USA
Depress Anxiety 25:742-51. 2008....- Heritability and clinical features of multigenerational families with obsessive-compulsive disorder and hoardingCarol A Mathews
Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 0984, USA
Am J Med Genet B Neuropsychiatr Genet 144:174-82. 2007..39 for hoarding. We found reasonable power to detect regions of interest (lod = 2) for OCD in these families, but will need to expand our family collection to have adequate power to detect regions of interest for hoarding... - Association between maternal smoking and increased symptom severity in Tourette's syndromeCarol A Mathews
Department of Psychiatry, University of California San Diego, La Jolla, CA, and the Department of Psychiatry, North Shore University Hospital New York University School of Medicine, Manhasset, NY, USA
Am J Psychiatry 163:1066-73. 2006.... - Comorbidity of bipolar disorder and substance abuse in Costa Rica: pedigree- and population-based studiesMichael A Escamilla
Department of Psychiatry, 7792, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA
J Affect Disord 71:71-83. 2002..Although SA/SD may be a risk factor for precipitating BPI in those at risk, in this population comorbid BPI subjects do not have a different onset or course of BPI in comparison to BPI patients without comorbidity... - Genomewide linkage disequilibrium mapping of severe bipolar disorder in a population isolateRoel A Ophoff
Neurogenetics Laboratory, University of California, San Francisco, CA, USA
Am J Hum Genet 71:565-74. 2002..This region could be important for severe psychiatric disorders, rather than for a specific phenotype... - Cognitive functioning in individuals with severe compulsive hoarding behaviors and late life depressionR Scott Mackin
Department of Psychiatry, University of California, San Francisco, USA
Int J Geriatr Psychiatry 26:314-21. 2011.... - The structure of obsessionality among young adultsCarol A Mathews
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0810, USA
Depress Anxiety 20:77-85. 2004.... - Results of a SNP genome screen in a large Costa Rican pedigree segregating for severe bipolar disorderSusan Service
Center for Neurobehavioral Genetics, University of California, Los Angeles, 90095-1761, USA
Am J Med Genet B Neuropsychiatr Genet 141:367-73. 2006..The difficulties of analyzing genome wide SNP data for complex disorders in large, potentially informative, kindreds are discussed... - Tic symptom profiles in subjects with Tourette Syndrome from two genetically isolated populationsCarol A Mathews
Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0810, USA
Biol Psychiatry 61:292-300. 2007..Tourette Syndrome (TS) has a complex etiology and wide variability in phenotypic expression. Identifying underlying symptom patterns may be useful for etiological and outcome studies of TS... - Anxiety symptoms and perceived performance in medical studentsUma Chandavarkar
School of Medicine, University of California, San Diego, La Jolla, California, USA
Depress Anxiety 24:103-11. 2007..In contrast, other anxiety symptoms appear to be maladaptive responses to external stressors... - A comparative study of obsessive-compulsive disorder in Costa Rica and the United StatesDenise A Chavira
Department of Psychiatry, University of California San Diego, San Diego, California 92037, USA
Depress Anxiety 25:609-19. 2008..However some features of OCD, such as impairment, may be culturally influenced, leading to differences in prevalence rates and treatment utilization... - Meta-analysis of the association between the catecholamine-O-methyl-transferase gene and obsessive-compulsive disorderAmin Azzam
University of California, San Francisco, California 92093 0810, USA
Am J Med Genet B Neuropsychiatr Genet 123:64-9. 2003..Subgroup stratification based on gender generated no statistically significant associations. These results should be considered in any future work correlating the COMT gene with OCD... - ADHD prevalence and association with hoarding behaviors in childhood-onset OCDBrooke Sheppard
Department of Psychiatry, University of California, San Francisco, 94143 0984, USA
Depress Anxiety 27:667-74. 2010.... - Genetic studies of neuropsychiatric disorders in Costa Rica: a model for the use of isolated populationsCarol A Mathews
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0810, USA
Psychiatr Genet 14:13-23. 2004..In this paper we highlight the studies currently being conducted by our groups in the Central Valley of Costa Rica to illustrate the potential advantages of this population for genetic studies... - Overrepresentation of rare variants in a specific ethnic group may confuse interpretation of association analysesDianne Keen-Kim
Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA
Hum Mol Genet 15:3324-8. 2006.... - Latent class analysis of gilles de la tourette syndrome using comorbidities: clinical and genetic implicationsMarco A Grados
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Biol Psychiatry 64:219-25. 2008..This study used latent class analyses (LCA) to identify GTS subphenotypes and assess characteristics and heritability of the classes... - Sequence variants in SLITRK1 are associated with Tourette's syndromeJesse F Abelson
Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
Science 310:317-20. 2005..Wild-type SLITRK1, but not the frameshift mutant, enhanced dendritic growth in primary neuronal cultures. Collectively, these findings support the association of rare SLITRK1 sequence variants with TS... - CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorderAnnemieke J M H Verkerk
Department of Clinical Genetics, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
Genomics 82:1-9. 2003....
Research Grants
- Mentored Patient-Oriented Research Career Development AwCarol Mathews; Fiscal Year: 2004..An additional study sample will be collected to investigate the role of these variables on TS spectrum disorders. Clinical and genetic information will be analyzed and correlations explored using a variety of statistical measures. ..
- An Affected SibPair Study of ADHD in Costa RicaCarol Mathews; Fiscal Year: 2009..Preliminary studies conducted in the CVCR show the feasibility of the sampling, diagnostic, and genotyping approaches described in this application. The sampling will be facilitated by ongoing collaborations established in the CVCR. ..