Research Topics
| C A MathewsSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Tic symptom profiles in subjects with Tourette Syndrome from two genetically isolated populationsCarol A Mathews
Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0810, USA
Biol Psychiatry 61:292-300. 2007..Tourette Syndrome (TS) has a complex etiology and wide variability in phenotypic expression. Identifying underlying symptom patterns may be useful for etiological and outcome studies of TS...- The structure of obsessionality among young adultsCarol A Mathews
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0810, USA
Depress Anxiety 20:77-85. 2004.... 
Self injurious behaviour in Tourette syndrome: correlates with impulsivity and impulse controlC A Mathews
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0810, USA
J Neurol Neurosurg Psychiatry 75:1149-55. 2004..Although SIB occurs in up to 60% of individuals with TS, and can cause significant clinical impairment and distress, little is known about its aetiology...- The effect on diagnostic rates of assigning patients to ethnically focused inpatient psychiatric unitsCarol A Mathews
Department of Psychiatry at the University of California, San Diego, 9500 Gilman Drive, 0810 La Jolla, California 92093 0810, USA
Psychiatr Serv 53:823-9. 2002.... - The effect on treatment outcomes of assigning patients to ethnically focused inpatient psychiatric unitsCarol A Mathews
Department of Psychiatry at the University of California, San Diego, 9500 Gilman Drive, 0810 La Jolla, California 92093 0810, USA
Psychiatr Serv 53:830-5. 2002..The authors examined whether assigning patients from three ethnic groups-blacks, Latinos, and Asians-to three ethnically focused psychiatric inpatient units would affect treatment outcome... - Genetic studies of neuropsychiatric disorders in Costa Rica: a model for the use of isolated populationsCarol A Mathews
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0810, USA
Psychiatr Genet 14:13-23. 2004..In this paper we highlight the studies currently being conducted by our groups in the Central Valley of Costa Rica to illustrate the potential advantages of this population for genetic studies... - Cultural influences on diagnosis and perception of Tourette syndrome in Costa RicaC A Mathews
Department of Psychiatry, University of California at San Francisco, 401 Parnassus Avenue, Box NGL 0984, San Francisco, CA 94143, USA
J Am Acad Child Adolesc Psychiatry 40:456-63. 2001..This study examines the phenomenology and presentation of TS in Costa Rica... - A comparative study of obsessive-compulsive disorder in Costa Rica and the United StatesDenise A Chavira
Department of Psychiatry, University of California San Diego, San Diego, California 92037, USA
Depress Anxiety 25:609-19. 2008..However some features of OCD, such as impairment, may be culturally influenced, leading to differences in prevalence rates and treatment utilization... - Anxiety symptoms and perceived performance in medical studentsUma Chandavarkar
School of Medicine, University of California, San Diego, La Jolla, California, USA
Depress Anxiety 24:103-11. 2007..In contrast, other anxiety symptoms appear to be maladaptive responses to external stressors... - Association between maternal smoking and increased symptom severity in Tourette's syndromeCarol A Mathews
Department of Psychiatry, University of California San Diego, La Jolla, CA, and the Department of Psychiatry, North Shore University Hospital New York University School of Medicine, Manhasset, NY, USA
Am J Psychiatry 163:1066-73. 2006.... - Assortative mating in the affective disorders: a systematic review and meta-analysisC A Mathews
Department of Psychiatry, University of California at San Francisco, 94143, USA
Compr Psychiatry 42:257-62. 2001..These results support the previously reported findings, and may have important implications for genetic studies... 
Evidence for a heritable unidimensional symptom factor underlying obsessionalityCarol A Mathews
Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 0984, USA
Am J Med Genet B Neuropsychiatr Genet 147:676-85. 2008..This component, which is heritable, accounts for the majority of the variation of the more traditionally derived symptom factors in our sample, and is composed of OCS that are not specific to any of the symptom subgroups...- Overrepresentation of rare variants in a specific ethnic group may confuse interpretation of association analysesDianne Keen-Kim
Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA
Hum Mol Genet 15:3324-8. 2006.... - ADHD prevalence and association with hoarding behaviors in childhood-onset OCDBrooke Sheppard
Department of Psychiatry, University of California, San Francisco, 94143 0984, USA
Depress Anxiety 27:667-74. 2010.... - Genetic linkage in bipolar disorderCarol A Mathews
Department of Psychiatry at the University of California, San Diego, San Diego, California, USA
CNS Spectr 8:891-904. 2003..New approaches, such as the use of genetically isolated populations and the use of endophenotypes for bipolar disorder, hold promise for continued advancement in the search to identify specific bipolar disorder genes... - Fine-scale mapping of a locus for severe bipolar mood disorder on chromosome 18p11.3 in the Costa Rican populationL A McInnes
Neurogenetics Laboratory, Center for Neurobiology and Psychiatry, and Department of Psychiatry, University of California, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 98:11485-90. 2001..Our results suggest a candidate region containing six genes but also highlight the complexities of LD mapping of common disorders... - Results of a SNP genome screen in a large Costa Rican pedigree segregating for severe bipolar disorderSusan Service
Center for Neurobehavioral Genetics, University of California, Los Angeles, 90095-1761, USA
Am J Med Genet B Neuropsychiatr Genet 141:367-73. 2006..The difficulties of analyzing genome wide SNP data for complex disorders in large, potentially informative, kindreds are discussed... - Childhood trauma and obsessive-compulsive symptomsCarol A Mathews
Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 0894, USA
Depress Anxiety 25:742-51. 2008.... - Heritability and clinical features of multigenerational families with obsessive-compulsive disorder and hoardingCarol A Mathews
Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 0984, USA
Am J Med Genet B Neuropsychiatr Genet 144:174-82. 2007..39 for hoarding. We found reasonable power to detect regions of interest (lod = 2) for OCD in these families, but will need to expand our family collection to have adequate power to detect regions of interest for hoarding... - Meta-analysis of the association between the catecholamine-O-methyl-transferase gene and obsessive-compulsive disorderAmin Azzam
University of California, San Francisco, California 92093 0810, USA
Am J Med Genet B Neuropsychiatr Genet 123:64-9. 2003..Subgroup stratification based on gender generated no statistically significant associations. These results should be considered in any future work correlating the COMT gene with OCD... - CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorderAnnemieke J M H Verkerk
Department of Clinical Genetics, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
Genomics 82:1-9. 2003.... - Latent class analysis of gilles de la tourette syndrome using comorbidities: clinical and genetic implicationsMarco A Grados
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
Biol Psychiatry 64:219-25. 2008..This study used latent class analyses (LCA) to identify GTS subphenotypes and assess characteristics and heritability of the classes... - Sequence variants in SLITRK1 are associated with Tourette's syndromeJesse F Abelson
Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
Science 310:317-20. 2005..Wild-type SLITRK1, but not the frameshift mutant, enhanced dendritic growth in primary neuronal cultures. Collectively, these findings support the association of rare SLITRK1 sequence variants with TS...