Anuja Mathew

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Defective pro-IL-1β responses in macrophages from aged mice
    Alejandro Ramirez
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, S6 862, 55 Lake Avenue North, Worcester, MA, 01655, USA
    Immun Ageing 9:27. 2012
  2. ncbi request reprint Identification of murine poxvirus-specific CD8+ CTL epitopes with distinct functional profiles
    Anuja Mathew
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 174:2212-9. 2005
  3. pmc Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia virus
    Anuja Mathew
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS ONE 3:e3323. 2008
  4. pmc B-cell responses during primary and secondary dengue virus infections in humans
    Anuja Mathew
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    J Infect Dis 204:1514-22. 2011
  5. pmc Analysis of human monoclonal antibodies generated by dengue virus-specific memory B cells
    Heather Friberg
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Viral Immunol 25:348-59. 2012
  6. pmc Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice
    Smita Jaiswal
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA
    Immunology 136:334-43. 2012
  7. pmc Memory CD8+ T cells from naturally acquired primary dengue virus infection are highly cross-reactive
    Heather Friberg
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunol Cell Biol 89:122-9. 2011
  8. pmc Cross-reactivity and expansion of dengue-specific T cells during acute primary and secondary infections in humans
    Heather Friberg
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Sci Rep 1:51. 2011
  9. pmc Differential in vivo clearance and response to secondary heterologous infections by H2(b)-restricted dengue virus-specific CD8+ T cells
    Coreen M Beaumier
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Viral Immunol 23:477-85. 2010
  10. doi request reprint Cross-reactive memory CD8(+) T cells alter the immune response to heterologous secondary dengue virus infections in mice in a sequence-specific manner
    Coreen M Beaumier
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Infect Dis 197:608-17. 2008

Collaborators

Detail Information

Publications18

  1. pmc Defective pro-IL-1β responses in macrophages from aged mice
    Alejandro Ramirez
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, S6 862, 55 Lake Avenue North, Worcester, MA, 01655, USA
    Immun Ageing 9:27. 2012
    ..abstract:..
  2. ncbi request reprint Identification of murine poxvirus-specific CD8+ CTL epitopes with distinct functional profiles
    Anuja Mathew
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 174:2212-9. 2005
    ..Identification of T cell epitopes on VV will enable further studies to increase our understanding of the role of CD8+ T cells in VV infection and assist in the design of new protective strategies...
  3. pmc Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia virus
    Anuja Mathew
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS ONE 3:e3323. 2008
    ..Vaccinia viruses have been used as a model for viral disease and as a protective live vaccine...
  4. pmc B-cell responses during primary and secondary dengue virus infections in humans
    Anuja Mathew
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    J Infect Dis 204:1514-22. 2011
    ..Our data suggest that the minor populations of serotype-cross-reactive B cells generated by primary DENV infection are preferentially expanded during secondary DENV infection...
  5. pmc Analysis of human monoclonal antibodies generated by dengue virus-specific memory B cells
    Heather Friberg
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Viral Immunol 25:348-59. 2012
    ..Further analyses showed that these two hMAbs bound conformation-dependent, reduction-sensitive epitopes on E protein. These data shed light on the breadth of DENV-specific hMAbs generated within a single immune donor...
  6. pmc Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice
    Smita Jaiswal
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA, USA
    Immunology 136:334-43. 2012
    ..The BLT-NSG mice will allow assessment of human immune responses to DENV vaccines and the effects of previous immunity on subsequent DENV infections...
  7. pmc Memory CD8+ T cells from naturally acquired primary dengue virus infection are highly cross-reactive
    Heather Friberg
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunol Cell Biol 89:122-9. 2011
    ..Our data support a model whereby the order of sequential DENV infections influences the immune response to secondary heterologous DENV infection, contributing to varying disease outcomes...
  8. pmc Cross-reactivity and expansion of dengue-specific T cells during acute primary and secondary infections in humans
    Heather Friberg
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Sci Rep 1:51. 2011
    ..These data confirm marked T cell activation and serotype-cross-reactivity during the febrile phase of dengue; however, A11-NS3(133)-specific responses did not correlate with prior antigenic exposure or current disease severity...
  9. pmc Differential in vivo clearance and response to secondary heterologous infections by H2(b)-restricted dengue virus-specific CD8+ T cells
    Coreen M Beaumier
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Viral Immunol 23:477-85. 2010
    ..These results should facilitate further studies of the in vivo effects of DENV-specific T cells, including the use of genetically modified mouse strains...
  10. doi request reprint Cross-reactive memory CD8(+) T cells alter the immune response to heterologous secondary dengue virus infections in mice in a sequence-specific manner
    Coreen M Beaumier
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Infect Dis 197:608-17. 2008
    ..These findings demonstrate that cross-reactive T cells from a primary infection alter the immune response during a heterologous secondary infection...
  11. pmc Intracellular cytokine production by dengue virus-specific T cells correlates with subclinical secondary infection
    Steven Hatch
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA, USA
    J Infect Dis 203:1282-91. 2011
    ....
  12. doi request reprint Understanding the contribution of cellular immunity to dengue disease pathogenesis
    Anuja Mathew
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Immunol Rev 225:300-13. 2008
    ....
  13. pmc Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice
    Smita Jaiswal
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 4:e7251. 2009
    ..The lack of a suitable animal model to study viral and immunological mechanisms of human dengue disease has been a deterrent to dengue research...
  14. pmc Long term recall of memory CD8 T cells in mice to first and third generation smallpox vaccines
    Sharone Green
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Vaccine 29:1666-76. 2011
    ..Our data indicate robust vaccinia-specific CD8(+) T cell recall responses to lethal secondary challenge in protected mice with no apparent effect of age on T cell pools established much earlier in life...
  15. pmc Extended interferon-alpha therapy accelerates telomere length loss in human peripheral blood T lymphocytes
    Joel M O'Bryan
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 6:e20922. 2011
    ..We tested the hypothesis that long-term interferon treatment would result in significant reduction in average telomere length in peripheral blood T lymphocytes...
  16. ncbi request reprint Dengue vaccine: opportunities and challenges
    Steven Hatch
    University of Massachusetts Medical School, Center for Infectious Disease and Vaccine Research, 55 Lake Avenue North S6 862, Worcester, MA 01655, USA
    IDrugs 11:42-5. 2008
    ..Shaping' the T-cell response may be the key to successful dengue vaccine design...
  17. ncbi request reprint IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma
    Benjamin D Medoff
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 168:5278-86. 2002
    ..Our results demonstrate that IP-10, a Th1-type chemokine, is up-regulated in allergic pulmonary inflammation and that this contributes to the airway hyperreactivity and Th2-type inflammation seen in this model of asthma...
  18. ncbi request reprint Cutting edge: Th2 cell trafficking into the allergic lung is dependent on chemoattractant receptor signaling
    Anuja Mathew
    Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 169:651-5. 2002
    ..These studies conclusively demonstrate that trafficking of Th2 cells into the lung is an active process dependent on chemoattractant receptors...