Daniel Mathalon

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Neurobiology of schizophrenia: search for the elusive correlation with symptoms
    Daniel H Mathalon
    Psychiatry Service, San Francisco VA Medical Center San Francisco, CA, USA
    Front Hum Neurosci 6:136. 2012
  2. pmc Neurophysiological Distinction between Schizophrenia and Schizoaffective Disorder
    Daniel H Mathalon
    Psychiatry Service, San Francisco VA Medical Center and Department of Psychiatry, University of California San Francisco, CA, USA
    Front Hum Neurosci 3:70. 2010
  3. pmc Auditory cortex responsiveness during talking and listening: early illness schizophrenia and patients at clinical high-risk for psychosis
    Veronica B Perez
    Department of Psychiatry, University of California, San Francisco UCSF, San Francisco, CA 94121, USA
    Schizophr Bull 38:1216-24. 2012
  4. pmc Automatic semantic priming abnormalities in schizophrenia
    Daniel H Mathalon
    Psychiatry Service, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Int J Psychophysiol 75:157-66. 2010
  5. pmc Error detection failures in schizophrenia: ERPs and FMRI
    Daniel H Mathalon
    Psychiatry Service, San Francisco VA Medical Center, and Department of Psychiatry, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Int J Psychophysiol 73:109-17. 2009
  6. ncbi Corollary discharge dysfunction in schizophrenia: evidence for an elemental deficit
    Daniel H Mathalon
    Psychiatry Service, San Francisco VA Medical Center, USA
    Clin EEG Neurosci 39:82-6. 2008
  7. ncbi Electrophysiological evidence of corollary discharge dysfunction in schizophrenia during talking and thinking
    Judith M Ford
    Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine, and Psychiatry Service, Veterans Affairs Medical Center, Palo Alto, USA
    J Psychiatr Res 38:37-46. 2004
  8. pmc Out-of-synch and out-of-sorts: dysfunction of motor-sensory communication in schizophrenia
    Judith M Ford
    Psychiatry Service, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA
    Biol Psychiatry 63:736-43. 2008
  9. ncbi Synch before you speak: auditory hallucinations in schizophrenia
    Judith M Ford
    Psychiatry Service, Veterans Affairs Connecticut Health Care System, USA
    Am J Psychiatry 164:458-66. 2007
  10. ncbi Dissecting corollary discharge dysfunction in schizophrenia
    Judith M Ford
    Psychiatry Service, Veterans Affairs Connecticut Healthcare System, West Haven 06517, and Department of Psychiatry, Yale University School of Medicne, New Haven, Connecticut, USA
    Psychophysiology 44:522-9. 2007

Research Grants

Detail Information

Publications41

  1. pmc Neurobiology of schizophrenia: search for the elusive correlation with symptoms
    Daniel H Mathalon
    Psychiatry Service, San Francisco VA Medical Center San Francisco, CA, USA
    Front Hum Neurosci 6:136. 2012
    ..We conclude with recommendations to promote progress in establishing brain-symptom relationships...
  2. pmc Neurophysiological Distinction between Schizophrenia and Schizoaffective Disorder
    Daniel H Mathalon
    Psychiatry Service, San Francisco VA Medical Center and Department of Psychiatry, University of California San Francisco, CA, USA
    Front Hum Neurosci 3:70. 2010
    ..Although both groups show similar deficits in processing speed, SA patients do not exhibit the P300 amplitude deficits evident in SZ, consistent with an underlying pathophysiological boundary between these disorders...
  3. pmc Auditory cortex responsiveness during talking and listening: early illness schizophrenia and patients at clinical high-risk for psychosis
    Veronica B Perez
    Department of Psychiatry, University of California, San Francisco UCSF, San Francisco, CA 94121, USA
    Schizophr Bull 38:1216-24. 2012
    ..Whether this abnormality precedes psychosis onset, emerges early in the illness, and/or progressively worsens with illness chronicity, is unknown...
  4. pmc Automatic semantic priming abnormalities in schizophrenia
    Daniel H Mathalon
    Psychiatry Service, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Int J Psychophysiol 75:157-66. 2010
    ....
  5. pmc Error detection failures in schizophrenia: ERPs and FMRI
    Daniel H Mathalon
    Psychiatry Service, San Francisco VA Medical Center, and Department of Psychiatry, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
    Int J Psychophysiol 73:109-17. 2009
    ....
  6. ncbi Corollary discharge dysfunction in schizophrenia: evidence for an elemental deficit
    Daniel H Mathalon
    Psychiatry Service, San Francisco VA Medical Center, USA
    Clin EEG Neurosci 39:82-6. 2008
    ....
  7. ncbi Electrophysiological evidence of corollary discharge dysfunction in schizophrenia during talking and thinking
    Judith M Ford
    Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine, and Psychiatry Service, Veterans Affairs Medical Center, Palo Alto, USA
    J Psychiatr Res 38:37-46. 2004
    ....
  8. pmc Out-of-synch and out-of-sorts: dysfunction of motor-sensory communication in schizophrenia
    Judith M Ford
    Psychiatry Service, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA
    Biol Psychiatry 63:736-43. 2008
    ..If it reflects the action of the efference copy, it should be related to subsequent sensory suppression. If efference copy/corollary discharge mechanisms are abnormal in schizophrenia, it should be reduced in patients with schizophrenia...
  9. ncbi Synch before you speak: auditory hallucinations in schizophrenia
    Judith M Ford
    Psychiatry Service, Veterans Affairs Connecticut Health Care System, USA
    Am J Psychiatry 164:458-66. 2007
    ..If so, schizophrenia patients should have reduced neural synchrony preceding movements, especially patients with severe hallucinations...
  10. ncbi Dissecting corollary discharge dysfunction in schizophrenia
    Judith M Ford
    Psychiatry Service, Veterans Affairs Connecticut Healthcare System, West Haven 06517, and Department of Psychiatry, Yale University School of Medicne, New Haven, Connecticut, USA
    Psychophysiology 44:522-9. 2007
    ..Agency and expectancy had modest suppression effects on N1 and only in controls. Group differences in expectancy and agency could not account for failed corollary discharge during talking in patients...
  11. pmc Dose-related modulation of event-related potentials to novel and target stimuli by intravenous Δ⁹-THC in humans
    DEEPAK CYRIL D'SOUZA
    Psychiatry Service, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Neuropsychopharmacology 37:1632-46. 2012
    ..Collectively, the findings suggest that CB1R systems modulate top-down and bottom-up processing...
  12. pmc Assessing corollary discharge in humans using noninvasive neurophysiological methods
    Judith M Ford
    Department of Psychiatry, San Francisco VA Medical Center, University of California, San Francisco, California, USA
    Nat Protoc 5:1160-8. 2010
    ..The successful action of the corollary discharge is seen when the response of the auditory cortex is suppressed during the Talk compared with the Listen condition. The protocol takes about 5 min to complete...
  13. pmc Neural synchrony in schizophrenia
    Judith M Ford
    Department of Psychiatry, University of California San Francisco, San Francisco, CA 94121, USA
    Schizophr Bull 34:904-6. 2008
    ..These papers illustrate approaches to translational neuroscience that will increase our understanding of schizophrenia and provide neurobiological endpoints for developing novel treatments...
  14. pmc The dependence of P300 amplitude on gamma synchrony breaks down in schizophrenia
    Judith M Ford
    Psychiatry Service, San Francisco VA Medical Center, Department of Psychiatry, University of California, San Francisco, CA 94121, USA
    Brain Res 1235:133-42. 2008
    ..We also asked whether people who have large P300s have higher power and greater synchrony of neural activity, and if the relationships between P300 and power and synchrony are different in patients and healthy controls...
  15. pmc When it's time for a change: failures to track context in schizophrenia
    Judith M Ford
    Psychiatry Service, San Francisco VA Medical Center, USA
    Int J Psychophysiol 78:3-13. 2010
    ..The improbable occurrence of a standard should generate a P300, but only if the implicit local context generated by the recent stimulus history is processed...
  16. pmc Brain-performance correlates of working memory retrieval in schizophrenia: a cognitive modeling approach
    Gregory G Brown
    Department of Psychiatry, University of California, San Diego, CA, USA
    Schizophr Bull 35:32-46. 2009
    ..The results show at both cognitive and neural levels that disordered memory scanning contributes to deficient SIRP performance among schizophrenia patients...
  17. pmc A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype
    Steven G Potkin
    Department of Psychiatry and Human Behavior, University of California, Irvine, CA 92617, USA
    Schizophr Bull 35:96-108. 2009
    ..We present an alternative strategy with increased statistical power over a case-control study that uses brain imaging as a quantitative trait (QT) in the context of a GWAS in schizophrenia...
  18. pmc Event-related EEG time-frequency analysis: an overview of measures and an analysis of early gamma band phase locking in schizophrenia
    Brian J Roach
    Mental Health Service, VAMC, San Francisco, CA 94121, USA
    Schizophr Bull 34:907-26. 2008
    ..We discuss the results in terms of pathophysiological mechanisms compromising event-related gamma phase synchrony in schizophrenia and further attempt to reconcile this finding with prior studies that failed to find this effect...
  19. pmc Divergent approaches converge on frontal lobe dysfunction in schizophrenia
    Daniel H Mathalon
    Am J Psychiatry 165:944-8. 2008
  20. ncbi Corollary discharge dysfunction in schizophrenia: can it explain auditory hallucinations?
    Judith M Ford
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Int J Psychophysiol 58:179-89. 2005
    ....
  21. ncbi Reduced communication between frontal and temporal lobes during talking in schizophrenia
    Judith M Ford
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5550, USA
    Biol Psychiatry 51:485-92. 2002
    ..Its dysfunction may underlie failure to recognize inner speech as self-generated and account for auditory hallucinations in schizophrenia...
  22. ncbi N400 and automatic semantic processing abnormalities in patients with schizophrenia
    Daniel H Mathalon
    Department of Psychiatry, VA Connecticut Healthcare System, West Haven 06516, USA
    Arch Gen Psychiatry 59:641-8. 2002
    ..Using N400, inferences can be drawn regarding the extent to which a given context primes a word...
  23. ncbi Response-monitoring dysfunction in aging and Alzheimer's disease: an event-related potential study
    Daniel H Mathalon
    Department of Psychiatry, Psychiatry Service 116A, Veterans Affairs Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT 06516, USA
    Neurobiol Aging 24:675-85. 2003
    ..In AD patients, CRN amplitude was affected by item certainty (assessed a week earlier), being larger to items that were idiosyncratically difficult for patients to name...
  24. ncbi Selective attention in schizophrenia: sparing and loss of executive control
    Daniel H Mathalon
    Psychiatry Service 116A, VA Connecticut Healthcare System, 950 Campbell Ave, West Haven, CT 06516, USA
    Am J Psychiatry 161:872-81. 2004
    ..Patients with schizophrenia have deficits in auditory selective attention, but whether these attention deficits are evident at the earliest stages of auditory processing or emerge later in the processing stream is unknown...
  25. ncbi Relationship of imprecise corollary discharge in schizophrenia to auditory hallucinations
    Theda H Heinks-Maldonado
    Department of Neuropsychology, Albert Ludwigs Universitat, Freiburg, Germany
    Arch Gen Psychiatry 64:286-96. 2007
    ..Imprecision of the corollary discharge in schizophrenia may contribute to the misperception of inner experiences and thoughts as "voices" or auditory hallucinations...
  26. ncbi A functional magnetic resonance imaging study of working memory abnormalities in schizophrenia
    Matthew R Johnson
    Olin Neuropsychiatry Research Center, The Institute of Living at Hartford Hospital, Hartford, CT, USA
    Biol Psychiatry 60:11-21. 2006
    ..We examined neural function changes at several WM loads to derive a more complete picture of WM dysfunction in schizophrenia...
  27. pmc Diffusion tensor imaging in schizophrenia: relationship to symptoms
    Laurie R Skelly
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT 06106, USA
    Schizophr Res 98:157-62. 2008
    ....
  28. pmc Chronic smoking and the BOLD response to a visual activation task and a breath hold task in patients with schizophrenia and healthy controls
    Lee Friedman
    PO Box 51, Newbury, OH 44065, USA
    Neuroimage 40:1181-94. 2008
    ....
  29. ncbi The long and the short of it: influence of interstimulus interval on auditory P300 abnormalities in schizophrenia
    Daniel H Mathalon
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Clin Electroencephalogr 33:125-35. 2002
    ..Implications for the cognitive significance of the P300 and its reduction in schizophrenia are discussed...
  30. ncbi Compounded brain volume deficits in schizophrenia-alcoholism comorbidity
    Daniel H Mathalon
    Department of Psychiatry, Yale University School of Medicine Veterans Affairs Connecticut Healthcare System, West Haven 06516, USA
    Arch Gen Psychiatry 60:245-52. 2003
    ..Schizophrenia and alcoholism are characterized by brain volume abnormalities. Despite the frequent comorbidity of these conditions, the potentially compounded effects of comorbidity on brain structure have seldom been rigorously assessed...
  31. ncbi Response-monitoring dysfunction in schizophrenia: an event-related brain potential study
    Daniel H Mathalon
    Department of Psychiatry, Yale University School of Medicine and Psychiatry Service and Veterans Affairs Healthcare System, West Haven, Connecticut, USA
    J Abnorm Psychol 111:22-41. 2002
    ..Despite ERN/CRN abnormalities, post-error slowing and Pe were normal in patients, suggesting a dissociation of ERN and error awareness. Anterior cingulate and dorsolateral prefrontal cortical dysfunction in schizophrenia are implicated...
  32. ncbi Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometry
    Daniel H Mathalon
    Arch Gen Psychiatry 60:846-8; author reply 848-9. 2003
  33. ncbi Are impairments of action monitoring and executive control true dissociative dysfunctions in patients with schizophrenia?
    And U Turken
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5550, USA
    Am J Psychiatry 160:1881-3. 2003
    ..Impaired self-monitoring is considered a critical deficit of schizophrenia. The authors asked whether this is a specific and isolable impairment or is part of a global disturbance of cognitive and attentional functions...
  34. ncbi Anatomy of an error: ERP and fMRI
    Daniel H Mathalon
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Biol Psychol 64:119-41. 2003
    ..Thus, error and conflict monitoring may be dissociable, subserved by both overlapping and distinct ACC regions...
  35. pmc Neural synchrony in schizophrenia: from networks to new treatments
    Judith M Ford
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Schizophr Bull 33:848-52. 2007
    ..Based on this, we argue that we can begin to use oscillations, across frequencies, to do translational studies to understand the neural basis of schizophrenia...
  36. ncbi Fine-tuning of auditory cortex during speech production
    Theda H Heinks-Maldonado
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
    Psychophysiology 42:180-90. 2005
    ..This is consistent with the operation of a precise forward model modulating the auditory cortical response to self-generated speech and allowing immediate distinction of self and externally generated auditory stimuli...
  37. ncbi Delayed hemodynamic responses in schizophrenia
    Judith M Ford
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuroimage 26:922-31. 2005
    ....
  38. ncbi Reduced gamma-band coherence to distorted feedback during speech when what you say is not what you hear
    Judith M Ford
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT Psychiatry Service, Veterans Affairs Connecticut Health Care System, West Haven, CT, United States
    Int J Psychophysiol 57:143-50. 2005
    ..We tested the hypothesis that there would be a disruption of gamma-band coherence when the expected auditory consequence of speech does not match the auditory experience...
  39. ncbi Acquiring and inhibiting prepotent responses in schizophrenia: event-related brain potentials and functional magnetic resonance imaging
    Judith M Ford
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif 94305 5550, USA
    Arch Gen Psychiatry 61:119-29. 2004
    ..Schizophrenia is associated with deficits in using context to establish prepotent responses in complex paradigms and failures to inhibit prepotent responses once established...

Research Grants2