A J Matas

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Morbidity and mortality after living kidney donation, 1999-2001: survey of United States transplant centers
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, MN, USA
    Am J Transplant 3:830-4. 2003
  2. pmc The unjustified classification of kidney donors as patients with CKD: critique and recommendations
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Clin J Am Soc Nephrol 8:1406-13. 2013
  3. doi request reprint Living donation: the global perspective
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Adv Chronic Kidney Dis 19:269-75. 2012
  4. pmc Ten-year outcome after rapid discontinuation of prednisone in adult primary kidney transplantation
    Michael D Rizzari
    Department of Surgery, Division of Transplantation, University of Minnesota, Minneapolis, 55455, USA
    Clin J Am Soc Nephrol 7:494-503. 2012
  5. doi request reprint Steroid minimization for sirolimus-treated renal transplant recipients
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, MN, USA
    Clin Transplant 25:457-67. 2011
  6. doi request reprint Histopathologic clusters differentiate subgroups within the nonspecific diagnoses of CAN or CR: preliminary data from the DeKAF study
    A J Matas
    Department of Surgery, University of Minnesota, Minneapolis, MN, USA
    Am J Transplant 10:315-23. 2010
  7. pmc Long-term immunosuppression, without maintenance prednisone, after kidney transplantation
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, USA
    Ann Surg 240:510-6; discussion 516-7. 2004
  8. ncbi request reprint The case for living kidney sales: rationale, objections and concerns
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minnesota, USA
    Am J Transplant 4:2007-17. 2004
  9. ncbi request reprint Resolved: in minimizing kidney transplant immunosuppression, steroids should go before calcineurin inhibitors: pro
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Am Soc Nephrol 18:3026-8. 2007
  10. ncbi request reprint Prednisone-free maintenance immunosuppression-a 5-year experience
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, USA
    Am J Transplant 5:2473-8. 2005

Research Grants

Collaborators

Detail Information

Publications97

  1. ncbi request reprint Morbidity and mortality after living kidney donation, 1999-2001: survey of United States transplant centers
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, MN, USA
    Am J Transplant 3:830-4. 2003
    ..Morbidity and mortality for living donor nephrectomy at transplant centers in the United States remain low. We provide current data from which comprehensive informed consent can be obtained from donors...
  2. pmc The unjustified classification of kidney donors as patients with CKD: critique and recommendations
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Clin J Am Soc Nephrol 8:1406-13. 2013
    ..This is definitely not the reward they deserve, and, more important, the implications of reduced GFR in donors are not associated with unfavorable outcomes. ..
  3. doi request reprint Living donation: the global perspective
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Adv Chronic Kidney Dis 19:269-75. 2012
    ..These markets have not provided protection for either donor or recipient. The transplant community has taken a unified stand against these underground unregulated markets...
  4. pmc Ten-year outcome after rapid discontinuation of prednisone in adult primary kidney transplantation
    Michael D Rizzari
    Department of Surgery, Division of Transplantation, University of Minnesota, Minneapolis, 55455, USA
    Clin J Am Soc Nephrol 7:494-503. 2012
    ..Although intermediate-term data with rapid discontinuation of prednisone have been promising, concern still exists regarding long-term outcomes. The 10-year experience is reported herein...
  5. doi request reprint Steroid minimization for sirolimus-treated renal transplant recipients
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, MN, USA
    Clin Transplant 25:457-67. 2011
    ..We herein review these trials and show that recent studies have determined that both late steroid withdrawal and early rapid discontinuation can be successful with SRL immunosuppression...
  6. doi request reprint Histopathologic clusters differentiate subgroups within the nonspecific diagnoses of CAN or CR: preliminary data from the DeKAF study
    A J Matas
    Department of Surgery, University of Minnesota, Minneapolis, MN, USA
    Am J Transplant 10:315-23. 2010
    ..We conclude that for recipients with new-onset late graft dysfunction, cluster analysis of Banff scores distinguishes meaningful subgroups with differing outcomes...
  7. pmc Long-term immunosuppression, without maintenance prednisone, after kidney transplantation
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, USA
    Ann Surg 240:510-6; discussion 516-7. 2004
    ..Concern exists that prednisone-free maintenance immunosuppression in kidney transplant recipients will increase acute and/or chronic rejection...
  8. ncbi request reprint The case for living kidney sales: rationale, objections and concerns
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minnesota, USA
    Am J Transplant 4:2007-17. 2004
    ..One potential solution would be a regulated system of living kidney sales (with safeguards to protect the vendor). Potential objections and practical concerns are discussed...
  9. ncbi request reprint Resolved: in minimizing kidney transplant immunosuppression, steroids should go before calcineurin inhibitors: pro
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Am Soc Nephrol 18:3026-8. 2007
    ..Without direct comparison or randomized controlled trials, two experts square off on the difficult choice of trying to reduce the usage of one of two drugs with well-known side effects after kidney transplantation...
  10. ncbi request reprint Prednisone-free maintenance immunosuppression-a 5-year experience
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, USA
    Am J Transplant 5:2473-8. 2005
    ..001), and fractures (p = 0.004). We conclude that prednisone-related side effects can be minimized in a protocol incorporating prednisone-free maintenance immunosuppression. Five-year graft outcome remains good...
  11. pmc Kidney transplant half-life (t[1/2]) after rapid discontinuation of prednisone
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Transplantation 87:100-2. 2009
    ..Our study suggests that long-term graft outcome is not decreased when using RDP protocols versus chronic maintenance prednisone...
  12. pmc Steroid elimination-who, when, how?
    A J Matas
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Transplant Proc 40:S52-6. 2008
    ..In these cases the acute rejection episode should be treated and long-term prednisone continued at 5 mg/d...
  13. pmc 2202 kidney transplant recipients with 10 years of graft function: what happens next?
    A J Matas
    Department of Surgery, University of Minnesota, Minneapolis, MN, USA
    Am J Transplant 8:2410-9. 2008
    ..We conclude that long-term transplant recipients have a high rate of morbidity and early mortality. As short-term results have improved, more focus is needed on long-term outcome...
  14. doi request reprint In defense of a regulated system of compensation for living donation
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Curr Opin Organ Transplant 13:379-85. 2008
    ..Herein, we provide justification for a regulated system of compensation for donation...
  15. doi request reprint Posttransplant diabetes mellitus and acute rejection: impact on kidney transplant outcome
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Transplantation 85:338-43. 2008
    ..The benefits (e.g., low acute rejection [AR] rate) vs. the long-term risk of each immunosuppressive protocol may determine the protocol's value...
  16. ncbi request reprint The current role of calcineurin inhibitors in posttransplant immunosuppression?
    A J Matas
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Transplant 6:2827-9. 2006
    ..Two major clinical series suggest the benefit of routine CNI-sparing approaches, but our review suggests weaknesses in both. Ongoing studies are needed to determine which subgroups of recipients will benefit from CNIs...
  17. doi request reprint Design of a regulated system of compensation for living kidney donors
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, MN, USA
    Clin Transplant 22:378-84. 2008
    ..To date, a detailed proposal on how such a system could work has not been developed. Herein, the specifics of a potential model, using the infrastructure already in place for deceased donor evaluation and allocation, are outlined...
  18. ncbi request reprint Why we should develop a regulated system of kidney sales: a call for action!
    Arthur J Matas
    University of Minnesota Surgery, Minneapolis, MN 55455, USA
    Clin J Am Soc Nephrol 1:1129-32. 2006
  19. pmc Minimization of steroids in kidney transplantation
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, 55455, USA
    Transpl Int 22:38-48. 2009
    ..Additional research is also necessary on integrating calcineurin inhibitor minimization with steroid minimization...
  20. ncbi request reprint Rapid discontinuation of steroids in living donor kidney transplantation: a pilot study
    A J Matas
    Department of Surgery, University of Minnesota, Minneapolis 55455, USA
    Am J Transplant 1:278-83. 2001
    ..Minimum follow-up was 5.5 months (range 5.5 to 17.5 months). Outcome was compared vs. previous cohorts of LD recipients immunosuppressed with P/AZA/CSA (n = 171) or P/MMF/CSA (n = 43) (both without antibody induction)...
  21. ncbi request reprint Five preventable causes of kidney graft loss in the 1990s: a single-center analysis
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Kidney Int 62:704-14. 2002
    ..Despite improvements in immunosuppressive protocols and patient care, kidney allografts continue to fail. We studied causes of graft loss for primary kidney transplants in the 1990s to determine major causes and potential interventions...
  22. pmc 2,500 living donor kidney transplants: a single-center experience
    A J Matas
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
    Ann Surg 234:149-64. 2001
    ..To review a single center's experience and outcome with living donor transplants...
  23. pmc Prospective randomized trial of maintenance immunosuppression with rapid discontinuation of prednisone in adult kidney transplantation
    T M Suszynski
    Department of Surgery, University of Minnesota, Minneapolis, MN, USA
    Am J Transplant 13:961-70. 2013
    ..These data indicate that RDP-based protocol yield acceptable 10-year outcomes, but side effects differ based on the maintenance regimen used and should be considered when optimizing immunosuppression following RDP...
  24. pmc Lessons learned from more than 1,000 pancreas transplants at a single institution
    D E Sutherland
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Ann Surg 233:463-501. 2001
    ..To determine outcome in diabetic pancreas transplant recipients according to risk factors and the surgical techniques and immunosuppressive protocols that evolved during a 33-year period at a single institution...
  25. pmc A composite risk model for predicting technical failure in pancreas transplantation
    E B Finger
    Department of Surgery, University of Minnesota, Minneapolis, MN, USA
    Am J Transplant 13:1840-9. 2013
    ..While the model suggests that two or more risk factors predict TF, strategies to reduce preservation time may mitigate some of this risk...
  26. pmc Selective retransplant after graft loss to nonadherence: success with a second chance
    T B Dunn
    Department of Surgery, University of Minnesota, Minneapolis, MN, USA
    Am J Transplant 9:1337-46. 2009
    ..With careful patient selection and aggressive intervention, prior overt NA should not be an absolute contraindication to retransplantation...
  27. ncbi request reprint Outcome at 3 years with a prednisone-free maintenance regimen: a single-center experience with 349 kidney transplant recipients
    Khalid Khwaja
    Department of Surgery, University of Minnesota, Minneapolis, MN
    Am J Transplant 4:980-7. 2004
    ..Currently, 84% of recipients remain prednisone-free. We conclude that excellent 3-year patient and graft survival can be achieved without maintenance prednisone. With such a protocol, steroid-related side-effects are minimal...
  28. ncbi request reprint Kidney transplantation in young children: should there be a minimum age?
    A Humar
    Department of Surgery, University of Minnesota, MMC 195, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Pediatr Nephrol 16:941-5. 2001
    ..Kidney transplant results in very young children can be comparable to those in older children. There need be no minimum age for performing a kidney transplant. The timing of the transplant should not be based on age or size alone...
  29. doi request reprint Earlier is not necessarily better in preemptive kidney transplantation
    S K Akkina
    Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN, USA
    Am J Transplant 8:2071-6. 2008
    ..05, p = 0.1588) for eGFR >or=15. Thus, early preemptive transplantation with higher eGFR does not necessarily improve graft survival after kidney transplantation, compared to preemptive transplantation with lower pretransplant eGFR...
  30. ncbi request reprint Immunologic factors: the major risk for decreased long-term renal allograft survival
    A Humar
    Department of Surgery, University of Minnesota, Minneapolis 55455, USA
    Transplantation 68:1842-6. 1999
    ..Both antigen-dependent (immunologic) and non-antigen-dependent (nonimmunologic) factors have been implicated in long-term renal allograft loss. Differentiating between these two factors is important because prevention strategies differ...
  31. ncbi request reprint Kidney and pancreas transplantation without a crossmatch in select circumstances--it can be done
    A J Matas
    Department of Surgery, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Clin Transplant 15:236-9. 2001
    ..Elimination of the screening XM for 0% PRA candidates saves money. Proceeding of the OR (if available) without a final XM shortens cold ischemia time...
  32. pmc Diabetes after kidney donation
    H N Ibrahim
    Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    Am J Transplant 10:331-7. 2010
    ....
  33. ncbi request reprint Kidney retransplants after initial graft loss to vascular thrombosis
    A Humar
    Department of Surgery, University of Minnesota, Minneapolis 55455, USA
    Clin Transplant 15:6-10. 2001
    ..Recipients with an identified disorder should undergo prophylaxis at the time of the retransplant. Results in these retransplant recipients are equivalent to those seen in primary transplant recipients...
  34. ncbi request reprint A multicenter pilot study of early (4-day) steroid cessation in renal transplant recipients under simulect, tacrolimus and sirolimus
    E Steve Woodle
    Division of Transplantation, Department of Surgery, University of Cincinnati, School of Medicine, Cincinnati, OH, USA
    Am J Transplant 5:157-66. 2005
    ....
  35. ncbi request reprint Are wound complications after a kidney transplant more common with modern immunosuppression?
    A Humar
    Department of Surgery, University of Minnesota, MMC 195, 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Transplantation 72:1920-3. 2001
    ..g., infections, hernias) in kidney recipients and to assess whether newer immunosuppressive drugs increase the risk for such complications...
  36. ncbi request reprint Peri-operative cardiac morbidity in kidney transplant recipients: incidence and risk factors
    A Humar
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Transplant 15:154-8. 2001
    ..Such patients require aggressive pre-operative investigations, which may include coronary angiography, to decrease the risk of post-transplant complications...
  37. ncbi request reprint Evolution of immunosuppression at the University of Minnesota
    A J Matas
    Department of Surgery, University of Minnesota, Minneapolis, MN, USA
    Transplant Proc 36:64S-70S. 2004
    ..The net result has been an incremental improvement in recipient and graft survival...
  38. ncbi request reprint Predictors of renal function following lung or heart-lung transplantation
    Areef Ishani
    Department of Medicine and Surgery, University of Minnesota, Minneapolis 55455, USA and Department of Nephrology Ankara University Medical School, Ankara, Turkey
    Kidney Int 61:2228-34. 2002
    ..The purpose of our study was to define the rate of decline in renal function and to identify independent risk factors associated with renal failure following lung or heart-lung transplantation...
  39. doi request reprint OPTN/SRTR 2011 Annual Data Report: kidney
    A J Matas
    Scientifc Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN, USA
    Am J Transplant 13:11-46. 2013
    ..Graft survival and short-term renal function continue to improve for pediatric recipients. Postransplant lymphoproliferative disorder is an important concern, occurring in about one-third of pediatric recipients...
  40. pmc Similar outcomes with different rates of delayed graft function may reflect center practice, not center performance
    S K Akkina
    Department of Medicine, University of Minnesota Medical Center, Minneapolis, MN, USA
    Am J Transplant 9:1460-6. 2009
    ..3741) to that of recipients with SGF at UMMC. We conclude that dialysis per se is likely not a cause of worse graft outcomes. A better definition is needed to measure early graft dysfunction and its effects across transplant programs...
  41. pmc Revisiting traditional risk factors for rejection and graft loss after kidney transplantation
    T B Dunn
    Department of Surgerya, University of Minnesota, Minneapolis, MN, USA
    Am J Transplant 11:2132-43. 2011
    ..The presence of DSA is an important predictor of rejection risk, in contrast to traditional risk factors. Further development of immunosuppressive protocols will be facilitated by stratification of rejection risk by donor sensitization...
  42. ncbi request reprint Kidney transplantation: a brief review
    A P Humar
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
    Front Biosci 2:e41-7. 1997
    ..This along with a better understanding of the processes that may ultimately lead to graft tolerance will be the major challenges facing the field of renal transplantation as it enters the 21st century...
  43. ncbi request reprint Mycobacterial infections after kidney transplant
    T Jie
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Transplant Proc 37:937-9. 2005
    ..With mean follow-up of 12.5 years since transplant and 9.2 years since infection, 13 of the recipients are alive and well; causes of death included cardiovascular (n = 3) and sepsis (n = 2)...
  44. ncbi request reprint Stable kidney function in the second decade after kidney transplantation while on cyclosporine-based immunosuppression
    Raja Kandaswamy
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Transplantation 83:722-6. 2007
    ..However, in some recipients, the adverse effects of CNIs contribute to chronic allograft nephropathy and death with function--the two leading causes of late graft loss. Other recipients maintain stable graft function...
  45. pmc Lower calcineurin inhibitor doses in older compared to younger kidney transplant recipients yield similar troughs
    P A Jacobson
    Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN, USA
    Am J Transplant 12:3326-36. 2012
    ..These data support age-related changes in CNI metabolism. Further studies are needed to determine optimal dosing of CNIs in the elderly...
  46. ncbi request reprint Predicting long-term kidney graft survival: can new trials be performed?
    Steven Paraskevas
    Department of Surgery, University of Minnesota, Minneapolis, MN, USA
    Transplantation 75:1256-9. 2003
    ..Despite better outcomes, graft failure continues over time...
  47. ncbi request reprint Long-term (20-37 years) follow-up of living kidney donors
    Thiagarajan Ramcharan
    Department of Surgery, University of Minnesota, MMC 328, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Am J Transplant 2:959-64. 2002
    ..However, some do develop renal dysfunction; some, renal failure. Our data underscore the need to develop prospective trials for long-term follow-up of kidney donors...
  48. doi request reprint OPTN/SRTR 2012 Annual Data Report: Kidney
    A J Matas
    Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN Department of Surgery, University of Minnesota, Minneapolis, MN
    Am J Transplant 14:11-44. 2014
    ..Rates of rehospitalization are high in the first year posttransplant; annual costs after the first year are lower. ..
  49. pmc Demographic, metabolic, and blood pressure characteristics of living kidney donors spanning five decades
    S J Taler
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA
    Am J Transplant 13:390-8. 2013
    ..The fraction of older donors accepted with glucose intolerance or hypertension remains small and for the majority includes mild elevations in glucose or blood pressure that were previously classified as within normal limits...
  50. pmc Pregnancy outcomes after kidney donation
    H N Ibrahim
    Division of Renal Diseases and Hypertension, University of Minnesota, Minneapolis, MN, USA
    Am J Transplant 9:825-34. 2009
    ....
  51. ncbi request reprint Risk factors for slow graft function after kidney transplants: a multivariate analysis
    A Humar
    Department of Surgery, University of Minnesota, Minneapolis, 55455, USA
    Clin Transplant 16:425-9. 2002
    ..recipients with IGF. The aim of our current study was to determine risk factors for SGF, which have not been well defined (in contrast to risk factors for DGF)...
  52. ncbi request reprint Risk factors for rising creatinine in renal allografts with 1 and 3 yr survival
    Steven Paraskevas
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Clin Transplant 20:667-72. 2006
    ..Determining factors associated with negative slope of inverse creatinine vs. time (1/Cr vs. t) may help prevent a decline in renal allograft function...
  53. ncbi request reprint Positive remote crossmatch: impact on short-term and long-term outcome in cadaver renal transplantation
    Harriet J Noreen
    Fairview University Medical Center, Minneapolis, MN, USA
    Transplantation 75:501-5. 2003
    ..Conflicting data have been reported concerning the significance of a positive crossmatch with "remote" sera (obtained months or years earlier) when the current crossmatch is negative...
  54. doi request reprint Pancreas after living donor kidney transplants in diabetic patients: impact on long-term kidney graft function
    Francois Kleinclauss
    Department of Surgery, Division of Renal Disease and Hypertension, University of Minnesota, Minneapolis, MN, USA
    Clin Transplant 23:437-46. 2009
    ..We conclude that the subsequent transplant of a pancreas after an LD kidney transplant does not adversely affect patient or kidney graft survival rates; in fact, it is associated with better long-term kidney graft function...
  55. doi request reprint Health-related quality of life in kidney donors from the last five decades: results from the RELIVE study
    C R Gross
    Department of Experimental and Clinical Pharmacology, College of Pharmacy and School of Nursing, University of Minnesota, Minneapolis, MN
    Am J Transplant 13:2924-34. 2013
    ..One percent reported that donation affected their health very negatively. Enhanced predonation evaluation and counseling may be warranted, along with ongoing monitoring for overweight donors. ..
  56. pmc Urinary Peptide patterns in native kidneys and kidney allografts
    Yan Zhang
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA
    Transplantation 87:1807-13. 2009
    ..Consequently, a noninvasive test for transplanted kidney health would provide a significant advantage over current clinical practice...
  57. pmc Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation
    Ajay Israni
    Department of Nephrology, Hennepin County Medical Center, University of Minnesota, Minneapolis, MN, USA
    Transplantation 90:1401-8. 2010
    ..Therefore, this study investigated single-nucleotide polymorphisms (SNPs) to identify genetic variants associated with AR, accounting for center variation, in a multicenter, prospective, observation study...
  58. pmc Genetic determinants of mycophenolate-related anemia and leukopenia after transplantation
    Pamala A Jacobson
    Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA
    Transplantation 91:309-16. 2011
    ..Toxicity leads to dose reduction, addition of colony-stimulating factors or erythropoietin, or discontinuation of immunosuppressive therapy. The causes of and risk factors associated with toxicity are unclear...
  59. pmc Novel polymorphisms associated with tacrolimus trough concentrations: results from a multicenter kidney transplant consortium
    Pamala A Jacobson
    Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
    Transplantation 91:300-8. 2011
    ..Although its effect is important, it incompletely explains the variability in tacrolimus concentrations and has a relatively low minor allele frequency in whites relative to African Americans (AA)...
  60. pmc Appraisal of GFR-estimating equations following kidney donation
    Meghan Sebasky
    Division of Renal Diseases and Hypertension, University of Minnesota, Minneapolis, MN 55414, USA
    Am J Kidney Dis 53:1050-8. 2009
    ..It is not clear which serum creatinine-based glomerular filtration rate (GFR)-estimating model performs best in kidney donors...
  61. ncbi request reprint Payment for living donor (vendor) kidneys: a cost-effectiveness analysis
    Arthur J Matas
    University of Minnesota, MN, USA
    Am J Transplant 4:216-21. 2004
    ..At a minimum, a vendor program would save society >$90,000 per transplant and provides QALYs for the ESRD population. Thus, society could break even while paying $90,000/kidney vendor...
  62. ncbi request reprint A prospective randomized trial of steroid-free maintenance regimens in kidney transplant recipients--an interim analysis
    Raja Kandaswamy
    Department of Surgery, University of Minnesota, Minneapolis, USA
    Am J Transplant 5:1529-36. 2005
    ..02); we found no other differences between groups in complication rates. Our data suggest that excellent patient and graft survival and low rejection rates can be obtained using a variety of maintenance protocols without prednisone...
  63. ncbi request reprint Long-term deterioration of kidney allograft function
    Bertram L Kasiske
    Department of Medicine, University of Minnesota, Minneapolis, USA
    Am J Transplant 5:1405-14. 2005
    ..78 (0.64-0.95), p = 0.0110 during 1999-2002 (compared to 1984-1989). We conclude that the rate of decline in allograft function after kidney transplantation has improved, suggesting that stable, long-term function may be achievable...
  64. ncbi request reprint Graft and quality of life outcomes in older recipients of a kidney transplant
    Abhinav Humar
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Clin Transplant 1:69-72. 2003
    ..We looked at outcomes, both medical and psychosocial, in a group of older (> or =65 years) kidney transplant recipients and compared the results to a group of younger recipients (18 to 64 years)...
  65. ncbi request reprint Rapid discontinuation of prednisone in higher-risk kidney transplant recipients
    Khalid Khwaja
    Department of Surgery, University of Minnesota, MN 55455, USA
    Transplantation 78:1397-9. 2004
    ..Our data suggests that such recipients should not be excluded from prednisone-minimization protocols...
  66. ncbi request reprint Cystatin C is not superior to creatinine-based models in estimating glomerular filtration rate in former kidney donors
    Daniel W Louvar
    Division of Renal Diseases and Hypertension, Minneapolis, MN, USA
    Transplantation 84:1112-7. 2007
    ..Whether cystatin C is superior to creatinine-based estimates of GFR in those who have donated a kidney in the past has not been tested...
  67. ncbi request reprint What's new and what's hot in transplantation: clinical science ATC 2003
    Arthur J Matas
    Department of Surgery, University of Minnesota, MMC 328 420 Delaware Street SE, Minneapolis, MN 55455, USA
    Am J Transplant 3:1465-73. 2003
  68. ncbi request reprint Plasma homocysteine levels in living kidney donors before and after uninephrectomy
    Michael Y Tsai
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, 55455 0392, USA
    J Lab Clin Med 143:340-3. 2004
    ..Our results, the first to be obtained from living kidney donors, support the hypothesis that renal metabolism of tHcy is the mechanism responsible for the correlation between renal function and plasma tHcy level...
  69. ncbi request reprint Medication noncompliance: another iceberg's tip
    Thomas E Nevins
    Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis, Minnesota, USA
    Transplantation 77:776-8. 2004
    ....
  70. ncbi request reprint Improved scoring system to assess adult donors for cadaver renal transplantation
    Scott L Nyberg
    Division of Transplantation Surgery, Mayo Clinic, Rochester, MN, USA
    Am J Transplant 3:715-21. 2003
    ..The improved system provides a quantitative approach to evaluation of marginal kidneys and may improve allocation of these organs in cadaver renal transplantation...
  71. pmc Long-term consequences of kidney donation
    Hassan N Ibrahim
    Department of Medicine, University of Minnesota, Minneapolis 55414, USA
    N Engl J Med 360:459-69. 2009
    ..Previous studies have included relatively small numbers of donors and a brief follow-up period...
  72. ncbi request reprint Surgical complications after kidney transplantation
    Abhinav Humar
    Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
    Semin Dial 18:505-10. 2005
    ..Examples include wound infection, renal artery or vein thrombosis, and urine leak. Most of these complications will require surgical or radiologic intervention for appropriate management...
  73. ncbi request reprint Preemptive kidney transplantation: the advantage and the advantaged
    Bertram L Kasiske
    The United States Renal Data System Coordinating Center, Minneapolis, Minnesota 55414, USA
    J Am Soc Nephrol 13:1358-64. 2002
    ..Alterations in the payment system, emphasis on early referral, and changes in cadaver kidney allocation could increase the number of patients who benefit from preemptive transplantation...
  74. ncbi request reprint Diabetes mellitus after kidney transplantation in the United States
    Bertram L Kasiske
    The United States Renal Data System Coordinating Center, Minneapolis, MN, USA
    Am J Transplant 3:178-85. 2003
    ..It is a strong, independent predictor of graft failure and mortality. Efforts should be made to minimize the risk of this important complication...
  75. ncbi request reprint Life satisfaction and adverse effects in renal transplant recipients: a longitudinal analysis
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, USA
    Clin Transplant 16:113-21. 2002
    ..This report examines the longitudinal relationship between adverse effects and QOL, with particular attention to the relative impact of adverse effects associated with immunosuppression...
  76. ncbi request reprint Morbidity from congenital hepatic fibrosis after renal transplantation for autosomal recessive polycystic kidney disease
    Khalid Khan
    Division of Pediatric Gastroenterology and Nutrition, University of Minnesota, Minneapolis 55455, USA
    Am J Transplant 2:360-5. 2002
    ..Complications of CHF developed in 79% of children who received a renal transplant for ARPKD. Mortality related to CHF occurred in 29% and accounted for 80% (4/5) of the deaths...
  77. ncbi request reprint Living or deceased donor kidney transplants for candidates with significant extrarenal morbidity
    Raja Kandaswamy
    Department of Surgery, University of Minnesota, Minneapolis, 55455, USA
    Clin Transplant 20:346-50. 2006
    ..However, it could be argued that for recipients with extrarenal morbidity, the potential benefit does not justify the donor risks and that, therefore, recipients with increased risks should be denied an LD transplant...
  78. ncbi request reprint Gas-generating systems in acute renal allograft rejection in the rat. Co-induction of heme oxygenase and nitric oxide synthase
    A Agarwal
    Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
    Transplantation 61:93-8. 1996
    ..Through a number of effects, these products of HO and iNOS may influence the nature and severity of tissue injury in AR...
  79. ncbi request reprint Death on the kidney waiting list--good candidates or not?
    V Casingal
    Department of Surgery, University of Minnesota, USA
    Am J Transplant 6:1953-6. 2006
    ..But only limited information was available; prospective studies are necessary to determine whether or not they were, in fact, good candidates...
  80. ncbi request reprint Why study kidney transplant risk factors?
    Arthur J Matas
    Medical School, University of Minnesota, Minneapolis, MN, USA
    Transplantation 75:266-7. 2003
  81. pmc Assessing elements of informed consent among living donors
    M Valapour
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA
    Clin Transplant 25:185-90. 2011
    ..Donors who are related to the recipient were more likely to report feeling pressure to donate. We conclude that more studies of informed consent are needed to identify factors that may compromise the validity of informed consent...
  82. ncbi request reprint Persistent, asymptomatic, microscopic hematuria in prospective kidney donors
    Rahul Koushik
    Departments of Medicine, Surgery, and Pathology, University of Minnesota, Minneapolis, MN 55455, USA
    Transplantation 80:1425-9. 2005
    ..Asymptomatic, microscopic hematuria is seen in 8-21% of the general population, has a good prognosis, and is generally not an indication for kidney biopsy. But whether it should preclude kidney donation is unclear...
  83. ncbi request reprint Twenty-two nondirected kidney donors: an update on a single center's experience
    Cheryl L Jacobs
    Fairview University Medical Center, University of Minnesota, Minneapolis, MN, USA
    Am J Transplant 4:1110-6. 2004
    ..Our experience continues to support nondirected donation for kidney transplants...
  84. ncbi request reprint Urinary beta2-microglobulin is associated with acute renal allograft rejection
    William S Oetting
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Am J Kidney Dis 47:898-904. 2006
    ..We attempted to identify novel biomarkers associated with AR by analyzing urinary proteins by using matrix-associated laser desorption ionization time-of-flight mass spectroscopy (MALDI-TOF MS)...
  85. pmc Should we pay donors to increase the supply of organs for transplantation? Yes
    Arthur J Matas
    Department of Surgery, University of Minnesota, 420 Delaware St SE, Minneapolis, Minnesota 55455, USA
    BMJ 336:1342. 2008
  86. ncbi request reprint Inhibition of the membrane attack complex of complement for induction of accommodation in the hamster-to-rat heart transplant model
    Benjamin D Suhr
    Department of Surgery, School of Medicine, University of Minnesota, Minneapolis, Minnisota, USA
    Xenotransplantation 14:572-9. 2007
    ....
  87. ncbi request reprint Prevention of post-transplant cardiovascular disease--report and recommendations of an ad hoc group
    Andrew D Bostom
    Department of Surgery, University of Minnesota, MMC 328 Mayo, Minneapolis 55455, USA
    Am J Transplant 2:491-500. 2002
  88. ncbi request reprint Proposed guidelines for re-evaluation of patients on the waiting list for renal cadaver transplantation
    Arthur J Matas
    Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA
    Transplantation 73:811-2. 2002
    ..Yet many wait a number of years before being transplanted. We propose guidelines for regular cardiac re-evaluation for patients on the waiting list...
  89. ncbi request reprint Do inherited hypercoagulable states play a role in thrombotic events affecting kidney/pancreas transplant recipients?
    Horacio E Adrogue
    Department of Medicine, O Brien Kidney Research Center, Baylor College of Medicine, Methodist Hospital, Houston, TX, USA
    Clin Transplant 21:32-7. 2007
    ..Pancreas graft thrombosis remains the leading non-immunologic cause of graft loss after pancreas transplantation. We studied the role of hypercoagulable states (HCS) in pancreas graft thrombosis (pthx)...
  90. doi request reprint Conversion from cyclosporine to tacrolimus in patients at risk for chronic renal allograft failure: 60-month results of the CRAF Study
    Fuad S Shihab
    Research and Development, University of Utah, Salt Lake City, UT 84132, USA
    Transplantation 85:1261-9. 2008
    ..This study compared the long-term effects of switching from cyclosporine to tacrolimus on the incidence, progression, and severity of chronic renal allograft failure in patients with elevated serum creatinine levels...
  91. ncbi request reprint Ethical incentives--not payment--for organ donation
    Arthur J Matas
    N Engl J Med 347:1382-4; author reply 1382-4. 2002
  92. ncbi request reprint Transplantation using marginal living donors
    Arthur J Matas
    Am J Kidney Dis 47:353-5. 2006
  93. ncbi request reprint The importance of innovative efforts to increase organ donation
    Arthur J Matas
    JAMA 294:1691-3. 2005
  94. ncbi request reprint Determinants of quality of life changes among long-term cardiac transplant survivors: results from longitudinal data
    Mark L Barr
    Department of Cardiothoracic Surgery, University of Southern California, Keck School of Medicine, 1510 San Pablo Street, Suite 415, Los Angeles, CA 90033 4612, USA
    J Heart Lung Transplant 22:1157-67. 2003
    ..This study examines both cross-sectional and longitudinal data from long-term survivors to identify factors that affect differences in QOL among recipients and individual changes in QOL during a 1-year period...
  95. ncbi request reprint Payment for living kidney donors (vendors) is not an abstract ethical discussion occurring in a vacuum
    Arthur J Matas
    Am J Transplant 4:1380-1. 2004
  96. ncbi request reprint The nondirected live-kidney donor: ethical considerations and practice guidelines: A National Conference Report
    Patricia L Adams
    Wake Forest University School of Medicine, USA
    Transplantation 74:582-9. 2002
    ..Other ethical issues such as the use of prisoners as an NDD, compensation for the NDD, media involvement, and communication between the NDD and recipient are discussed...
  97. ncbi request reprint Reproduction and transplantation: report on the AST Consensus Conference on Reproductive Issues and Transplantation
    Dianne B McKay
    Transplantation Medicine, The Scripps Clinic Scripps Green Hospital, The Scripps Research Institute, La Jolla, California, USA
    Am J Transplant 5:1592-9. 2005
    ..The manuscript summarizes the deliberations and conclusions of the conference as well as specific recommendations based on current knowledge in the field...

Research Grants5

  1. Long-term Deterioration of Kidney Allograft Function
    Arthur Matas; Fiscal Year: 2007
    ..Defining clinico-pathologic entities (and their individual clinical courses) will provide a knowledge base for future studies of CGD. ..
  2. Clinical Center - Outcomes of Live Organ Donors
    Arthur Matas; Fiscal Year: 2007
    ..In addition, this study will be the first study of the informed consent process in relation to living donation. Information gained will be important to address and perhaps change the informed consent process for future living donors. ..