Sadis Matalon

Summary

Affiliation: University of Alabama at Birmingham
Country: USA

Publications

  1. ncbi request reprint Regulation of ion channel structure and function by reactive oxygen-nitrogen species
    Sadis Matalon
    Department of Physiology, University of Alabama at Birmingham, Rm 224, BMR II, 901 S 19th St, Birmingham, AL 35205 3703, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1184-9. 2003
  2. ncbi request reprint Surfactant proteins and inflammation: the yin and the yang
    Sadis Matalon
    Department of Anesthesiology, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, Alabama 35294 2172, USA
    Am J Respir Cell Mol Biol 31:585-6. 2004
  3. pmc DETANO and nitrated lipids increase chloride secretion across lung airway cells
    Lan Chen
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35205 3703, USA
    Am J Respir Cell Mol Biol 39:150-62. 2008
  4. ncbi request reprint Regulation of amiloride-sensitive Na(+) transport by basal nitric oxide
    Karin M Hardiman
    Department of Physiology, Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, 901 19th Street S, Birmingham, AL 35205 3703, USA
    Am J Respir Cell Mol Biol 30:720-8. 2004
  5. pmc Regulation of alveolar epithelial Na+ channels by ERK1/2 in chlorine-breathing mice
    Ahmed Lazrak
    Department of Anesthesiology, School of Medicine, University of Alabama at Birmingham, BMR II 224, 901 19th St South, Birmingham, AL 35205 3703, USA
    Am J Respir Cell Mol Biol 46:342-54. 2012
  6. pmc Post-infection A77-1726 blocks pathophysiologic sequelae of respiratory syncytial virus infection
    Ian C Davis
    Department of Anesthesiology, University of Alabama at Birmingham, BMR II, Birmingham, AL 35205 3703, USA
    Am J Respir Cell Mol Biol 37:379-86. 2007
  7. pmc Inhibition of lung fluid clearance and epithelial Na+ channels by chlorine, hypochlorous acid, and chloramines
    Weifeng Song
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama 35205, USA
    J Biol Chem 285:9716-28. 2010
  8. pmc Respiratory syncytial virus inhibits lung epithelial Na+ channels by up-regulating inducible nitric-oxide synthase
    Weifeng Song
    Department of Anesthesiology, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    J Biol Chem 284:7294-306. 2009
  9. pmc Inhibition of Na+ transport in lung epithelial cells by respiratory syncytial virus infection
    Lan Chen
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35205 3703, USA
    Am J Respir Cell Mol Biol 40:588-600. 2009
  10. ncbi request reprint Interregulation of proton-gated Na(+) channel 3 and cystic fibrosis transmembrane conductance regulator
    Xuefeng Su
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama 35205, USA
    J Biol Chem 281:36960-8. 2006

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Regulation of ion channel structure and function by reactive oxygen-nitrogen species
    Sadis Matalon
    Department of Physiology, University of Alabama at Birmingham, Rm 224, BMR II, 901 S 19th St, Birmingham, AL 35205 3703, USA
    Am J Physiol Lung Cell Mol Physiol 285:L1184-9. 2003
    ....
  2. ncbi request reprint Surfactant proteins and inflammation: the yin and the yang
    Sadis Matalon
    Department of Anesthesiology, University of Alabama at Birmingham, 1530 3rd Avenue South, Birmingham, Alabama 35294 2172, USA
    Am J Respir Cell Mol Biol 31:585-6. 2004
  3. pmc DETANO and nitrated lipids increase chloride secretion across lung airway cells
    Lan Chen
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35205 3703, USA
    Am J Respir Cell Mol Biol 39:150-62. 2008
    ..These findings suggest that small concentrations of NO donors may prove beneficial in stimulating Cl- secretion across airway cells without promoting alveolar edema...
  4. ncbi request reprint Regulation of amiloride-sensitive Na(+) transport by basal nitric oxide
    Karin M Hardiman
    Department of Physiology, Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, 901 19th Street S, Birmingham, AL 35205 3703, USA
    Am J Respir Cell Mol Biol 30:720-8. 2004
    ....
  5. pmc Regulation of alveolar epithelial Na+ channels by ERK1/2 in chlorine-breathing mice
    Ahmed Lazrak
    Department of Anesthesiology, School of Medicine, University of Alabama at Birmingham, BMR II 224, 901 19th St South, Birmingham, AL 35205 3703, USA
    Am J Respir Cell Mol Biol 46:342-54. 2012
    ..The reactive intermediates formed during and after exposure to Cl(2) activated ERK1/2 in ATII cells in vitro and in vivo, leading to decreased ENaC concentrations and activity...
  6. pmc Post-infection A77-1726 blocks pathophysiologic sequelae of respiratory syncytial virus infection
    Ian C Davis
    Department of Anesthesiology, University of Alabama at Birmingham, BMR II, Birmingham, AL 35205 3703, USA
    Am J Respir Cell Mol Biol 37:379-86. 2007
    ..Post-infection intranasal or aerosolized treatment with pyrimidine synthesis inhibitors may provide symptomatic relief from the pathophysiologic sequelae of impaired AFC in children with RSV bronchiolitis...
  7. pmc Inhibition of lung fluid clearance and epithelial Na+ channels by chlorine, hypochlorous acid, and chloramines
    Weifeng Song
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama 35205, USA
    J Biol Chem 285:9716-28. 2010
    ..We concluded that HOCl and its reactive intermediates (such as organic chloramines) inhibit ENaC by affecting channel gating, which could be relieved by proteases cleavage...
  8. pmc Respiratory syncytial virus inhibits lung epithelial Na+ channels by up-regulating inducible nitric-oxide synthase
    Weifeng Song
    Department of Anesthesiology, Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
    J Biol Chem 284:7294-306. 2009
    ..Thus, both UTP- and iNOS-generated reactive species contribute to ENaC down-regulation in RSV-infected airway epithelial cells...
  9. pmc Inhibition of Na+ transport in lung epithelial cells by respiratory syncytial virus infection
    Lan Chen
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35205 3703, USA
    Am J Respir Cell Mol Biol 40:588-600. 2009
    ..These findings are consistent with our previous studies showing reduced alveolar fluid clearance after RSV infection of BALB/c mice...
  10. ncbi request reprint Interregulation of proton-gated Na(+) channel 3 and cystic fibrosis transmembrane conductance regulator
    Xuefeng Su
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama 35205, USA
    J Biol Chem 281:36960-8. 2006
    ....
  11. pmc Administration of nitrite after chlorine gas exposure prevents lung injury: effect of administration modality
    Andrey A Samal
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Free Radic Biol Med 53:1431-9. 2012
    ..These data highlight the potential for nitrite as a postexposure therapeutic for Cl(2) gas-induced lung injury and also suggest that administration modality is a key consideration in nitrite therapeutics...
  12. pmc Enhancement of alveolar epithelial sodium channel activity with decreased cystic fibrosis transmembrane conductance regulator expression in mouse lung
    Ahmed Lazrak
    Department of Anesthesiology, School of Medicine, University of Alabama at Birmingham, 35205 3703, USA
    Am J Physiol Lung Cell Mol Physiol 301:L557-67. 2011
    ..This is the first demonstration of functional ENaC-CFTR interactions in alveolar epithelial cells in situ...
  13. pmc Post-exposure antioxidant treatment in rats decreases airway hyperplasia and hyperreactivity due to chlorine inhalation
    Michelle V Fanucchi
    Department of Environmental Health Science, School of Public Health, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Respir Cell Mol Biol 46:599-606. 2012
    ....
  14. pmc SARS-CoV proteins decrease levels and activity of human ENaC via activation of distinct PKC isoforms
    Hong Long Ji
    Department of Anesthesiology, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama 35233 6810, USA
    Am J Physiol Lung Cell Mol Physiol 296:L372-83. 2009
    ..These findings indicate that lung edema in SARS infection may be due at least in part to activation of PKC by SARS proteins, leading to decreasing levels and activity of ENaC at the apical surfaces of lung epithelial cells...
  15. pmc Bactericidal function of alveolar macrophages in mechanically ventilated rabbits
    Nina G Hall
    Department of Anesthesiology, The University of Alabama at Birmingham, Birmingham, AL 35233 6810, USA
    Am J Respir Cell Mol Biol 34:719-26. 2006
    ..These results suggest that the traditional ventilator approach (12 ml/kg VT) in a model of in vivo mechanical ventilation results in lung pathology without affecting AM antibacterial function...
  16. pmc Influenza matrix protein 2 alters CFTR expression and function through its ion channel activity
    James D Londino
    Department of Anesthesiology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA
    Am J Physiol Lung Cell Mol Physiol 304:L582-92. 2013
    ..Alteration of CFTR activity has important consequences for fluid regulation and may potentially modify the immune response to viral infection...
  17. pmc Respiratory syncytial virus induces insensitivity to beta-adrenergic agonists in mouse lung epithelium in vivo
    Ian C Davis
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35205 3703, USA
    Am J Physiol Lung Cell Mol Physiol 293:L281-9. 2007
    ....
  18. ncbi request reprint Mechanisms of cystic fibrosis transmembrane conductance regulator activation by S-nitrosoglutathione
    Lan Chen
    Department of Anesthesiology, University of Alabama, Birmingham, Alabama 35233, USA
    J Biol Chem 281:9190-9. 2006
    ..Oxy-Mb did not reverse the increase of I(sc) following addition of GSNO and cysteine (50 mum). These findings indicate that GSNO stimulates Cl secretion via both cGMP-dependent and cGMP-independent mechanisms...
  19. pmc Mitigation of chlorine gas lung injury in rats by postexposure administration of sodium nitrite
    Amit K Yadav
    Departments of Environmental Health Sciences, Schools of Public Health and Medicine, University of Alabama at Birmingham, USA
    Am J Physiol Lung Cell Mol Physiol 300:L362-9. 2011
    ..F(2)-isoprostane levels increased at 6 and 24 h after Cl(2) exposure in NO(2)(-)- and saline-injected rats. This is the first demonstration that systemic NO(2)(-) administration mitigates airway and epithelial injury...
  20. pmc Chlorine gas exposure causes systemic endothelial dysfunction by inhibiting endothelial nitric oxide synthase-dependent signaling
    Jaideep Honavar
    Department of Pathology, University of Alabama at Birmingham, 35294, USA
    Am J Respir Cell Mol Biol 45:419-25. 2011
    ..These results highlight the potential for Cl(2) exposure to promote postexposure systemic endothelial dysfunction via disruption of vascular NO homeostasis mechanisms...
  21. pmc Titanium oxide nanoparticle instillation induces inflammation and inhibits lung development in mice
    Namasivayam Ambalavanan
    Department of Pediatrics, University of Alabama at Birmingham, 176F Suite 9380, 619 South 20 St, Birmingham, AL 35233, USA
    Am J Physiol Lung Cell Mol Physiol 304:L152-61. 2013
    ....
  22. pmc Ascorbate and deferoxamine administration after chlorine exposure decrease mortality and lung injury in mice
    Sotirios G Zarogiannis
    Department of Anesthesiology, School of Medicine and Public Health, University of Alabama at Birmingham, 35294, USA
    Am J Respir Cell Mol Biol 45:386-92. 2011
    ..Administration of ascorbate and deferoxamine reduces mortality and decreases lung injury through reduction of alveolar-capillary permeability, inflammation, and epithelial sloughing and lipid peroxidation...
  23. pmc Functional stability of rescued delta F508 cystic fibrosis transmembrane conductance regulator in airway epithelial cells
    Asta Jurkuvenaite
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Respir Cell Mol Biol 42:363-72. 2010
    ....
  24. pmc Alpha(1)-antitrypsin inhibits epithelial Na+ transport in vitro and in vivo
    Ahmed Lazrak
    Department of Anesthesiology, University of Alabama at Birmingham, 224 BMR II, 901 South 19th Street, Birmingham, AL 35205 3703, USA
    Am J Respir Cell Mol Biol 41:261-70. 2009
    ..These data indicate that A1AT may be an important modulator of ENaC activity and of Na(+)-dependent fluid clearance across the distal lung epithelium in vivo by decreasing endogenous protease activity needed to activate silent ENaC...
  25. pmc Reactive species mediate inhibition of alveolar type II sodium transport during mycoplasma infection
    Judy M Hickman-Davis
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35205 3703, USA
    Am J Respir Crit Care Med 173:334-44. 2006
    ..Mycoplasma pneumoniae is a significant cause of pneumonia in humans...
  26. pmc Chlorine gas exposure increases susceptibility to invasive lung fungal infection
    Melissa A Gessner
    Department of Medicine, Pulmonary Injury and Repair Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Physiol Lung Cell Mol Physiol 304:L765-73. 2013
    ..fumigatus. In summary, our results indicate that Cl₂ exposure markedly impairs the antimicrobial activity and inflammatory reactivity of myeloid cells in the lung leading to increased susceptibility to opportunistic pathogens...
  27. ncbi request reprint cAMP-induced changes of apical membrane potentials of confluent H441 monolayers
    Ahmed Lazrak
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35205 3703, USA
    Am J Physiol Lung Cell Mol Physiol 285:L443-50. 2003
    ....
  28. pmc Mechanisms and modification of chlorine-induced lung injury in animals
    Amit K Yadav
    Department of Anesthesiology, University of Alabama at Birmingham, 901 19th Street South, Birmingham, AL 35294, USA
    Proc Am Thorac Soc 7:278-83. 2010
    ..The clinical challenge is to deliver sufficient quantities of antioxidants noninvasively, after Cl(2) exposure, to decrease morbidity and mortality...
  29. pmc Regulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation
    Dario A Vitturi
    Dept of Pathology, Univ of Alabama at Birmingham, 901 19th St S, BMR 2, Rm 302, Birmingham, AL 35294, USA
    Am J Physiol Heart Circ Physiol 296:H1398-407. 2009
    ....
  30. ncbi request reprint Delta-subunit confers novel biophysical features to alpha beta gamma-human epithelial sodium channel (ENaC) via a physical interaction
    Hong Long Ji
    Department of Anesthesiology, University of Alabama at Birmingham, Alabama 35205, USA
    J Biol Chem 281:8233-41. 2006
    ..We, therefore, concluded that the interactions of delta-ENaC with other subunits could account for heterogeneity of native epithelial channels...
  31. ncbi request reprint Enhanced cell-surface stability of rescued DeltaF508 cystic fibrosis transmembrane conductance regulator (CFTR) by pharmacological chaperones
    Karoly Varga
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biochem J 410:555-64. 2008
    ..The results indicate that small molecular correctors may reproduce the effect of incubation at the permissive temperature, not only by rescuing DeltaF508 CFTR from ERAD, but also by enhancing its cell-surface stability...
  32. pmc Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species
    Ahmed Lazrak
    Department of Anesthesiology, Schools of Medicine and Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA
    FASEB J 23:3829-42. 2009
    ..These novel findings suggest a mechanism for the influenza-induced rhinorrhea and life-threatening alveolar edema in humans...
  33. ncbi request reprint Modulation of sodium transport in fetal alveolar epithelial cells by oxygen and corticosterone
    Ulrich H Thome
    Department of Pediatrics, University of Alabama at Birmingham, 901 19th Street South, Birmingham, AL 35226, USA
    Am J Physiol Lung Cell Mol Physiol 284:L376-85. 2003
    ..We conclude that higher O(2) concentrations increased total vectorial Na(+) transport, and the function of Na(+)-K(+)-ATPase and apical amiloride-sensitive Na(+) conductance, whereas CST only increased ENaC function...
  34. doi request reprint Nano-TiO₂ particles impair adhesion of airway epithelial cells to fibronectin
    Sotirios G Zarogiannis
    Department of Anesthesiology, University of Alabama at Birmingham, 35294 Birmingham, AL, USA
    Respir Physiol Neurobiol 185:454-60. 2013
    ..In conclusion, short-term exposure of H441 cells to nano-TiO(2) appears to reduce adherence to fibronectin due to oxidative stress and activation of ERK1/2...
  35. pmc The CFTR and ENaC debate: how important is ENaC in CF lung disease?
    James F Collawn
    Department of Cell, Developmental and Integrative Biology, School of Medicine, University of Alabama at Birmingham, 35294 0005, USA
    Am J Physiol Lung Cell Mol Physiol 302:L1141-6. 2012
    ..Here we discuss the arguments for and against the role of the epithelial sodium channel, ENaC, in the development of CF lung disease...
  36. doi request reprint Comparison of ribavirin and oseltamivir in reducing mortality and lung injury in mice infected with mouse adapted A/California/04/2009 (H1N1)
    Sotirios G Zarogiannis
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Life Sci 90:440-5. 2012
    ..To compare the efficacy of ribavirin and oseltamivir in reducing mortality, lung injury and cytokine response profile in pandemic influenza H1N1 (2009) infection...
  37. pmc Postexposure administration of a {beta}2-agonist decreases chlorine-induced airway hyperreactivity in mice
    Weifeng Song
    901 19th Street South, 224 BMR2, Birmingham, AL 35294, USA
    Am J Respir Cell Mol Biol 45:88-94. 2011
    ..Our results provide mechanistic insight into the effectiveness of long-term β(2)-agonists in reversing Cl(2)-induced reactive airway dysfunction syndrome and injury to distal lung epithelial cells...
  38. pmc Leflunomide prevents alveolar fluid clearance inhibition by respiratory syncytial virus
    Ian C Davis
    Department of Anesthesiology, University of Alabama at Birmingham, 224 BMR II, 901 South 19th Street, Birmingham, AL 35205 3703, USA
    Am J Respir Crit Care Med 173:673-82. 2006
    ..Previously, we demonstrated that intranasal infection of BALB/c mice with respiratory syncytial virus (RSV) resulted in an early 40% reduction in alveolar fluid clearance (AFC), an effect mediated via P2Y purinergic receptors...
  39. ncbi request reprint Hyperoxia impairs antibacterial function of macrophages through effects on actin
    Philip J O'Reilly
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Alabama at Birmingham, 35205 3703, USA
    Am J Respir Cell Mol Biol 28:443-50. 2003
    ..We conclude that oxidative stress in vitro and in vivo impairs macrophage antibacterial function through effects on actin...
  40. ncbi request reprint Mutations in the extracellular loop of alpha-rENaC alter sensitivity to amiloride and reactive species
    Lan Chen
    Dept of Anesthesiology, Univ of Alabama at Birmingham, 901 19th St S, BMR II, Rm 224, Birmingham, AL 35205 3703, USA
    Am J Physiol Renal Physiol 286:F1202-8. 2004
    ..These data indicate that both tyrosines are important for proper ENaC function and their oxidative modifications contribute to altered ENaC function...
  41. ncbi request reprint Role of surfactant protein-A in nitric oxide production and mycoplasma killing in congenic C57BL/6 mice
    Judy M Hickman-Davis
    Department of Anesthesiology, University of Alabama at Birmingham, UAB Dept of Anesthesiology, 1530 3rd Ave South, Birmingham, AL 35294 2172, USA
    Am J Respir Cell Mol Biol 30:319-25. 2004
    ..e., suppression of NO in the absence of bacteria and increased NO in the presence of bacteria. These data indicate that the contribution of SP-A to mycoplasma killing may be limited to lower doses of pathogens...
  42. ncbi request reprint Novel SIN-1 reactive intermediates modulate chloride secretion across murine airway cells
    Ulrich Thome
    Division of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294 2172, USA
    Free Radic Biol Med 35:662-75. 2003
    ..We conclude that compounds formed by the reaction of peroxynitrite with by-products of SIN-1, rather than reactive oxygen-nitrogen species per se, were responsible for the modulation of Cl- secretion across primary cultures of MTE cells...
  43. ncbi request reprint Reactive oxygen nitrogen species decrease cystic fibrosis transmembrane conductance regulator expression and cAMP-mediated Cl- secretion in airway epithelia
    Zsuzsa Bebok
    Department of Medicine, and The Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama, Birmingham, Alabama 35233, USA
    J Biol Chem 277:43041-9. 2002
    ..Decreased levels and function of normal CFTR may account for some of the cystic fibrosis-like symptoms that occur in chronic inflammatory lung diseases associated with increased NO production...
  44. pmc Mitigation of chlorine-induced lung injury by low-molecular-weight antioxidants
    Martin Leustik
    Department of Anesthesiology, University of Alabama at Birmingham, 901 19th Street South, Birmingham, AL 35205 3703, USA
    Am J Physiol Lung Cell Mol Physiol 295:L733-43. 2008
    ..These findings suggest that Cl(2) inhalation damages both airway and alveolar epithelial tissues and that resulting effects were ameliorated by prophylactic administration of low-molecular-weight antioxidants...
  45. doi request reprint Inhibition of epithelial sodium channels by respiratory syncytial virus in vitro and in vivo
    Weifeng Song
    Department of Anesthesiology and Pulmonary Injury and Repair Center, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Ann N Y Acad Sci 1203:79-84. 2010
    ..These findings indicate that the harmful effects of RSV on lung epithelia are mediated at least in part via the production of UTP and its paracrine action on ENaC...
  46. ncbi request reprint Nucleotide-mediated inhibition of alveolar fluid clearance in BALB/c mice after respiratory syncytial virus infection
    Ian C Davis
    Department of Anesthesiology, University of Alabama at Birmingham, 35233, USA
    Am J Physiol Lung Cell Mol Physiol 286:L112-20. 2004
    ..Reduced AFC may result in formation of an increased volume of fluid mucus, airway congestion, and rhinorrhea, all features of severe RSV disease...
  47. ncbi request reprint Lipopolysaccharide increases alveolar type II cell number in fetal mouse lungs through Toll-like receptor 4 and NF-kappaB
    Lawrence S Prince
    Department of Pediatrics, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
    Am J Physiol Lung Cell Mol Physiol 287:L999-1006. 2004
    ..These data implicate an important signaling mechanism in chorioamnionitis and suggest the TLR4/NF-kappaB pathway can influence lung development...
  48. ncbi request reprint Regulation of Na+ channels in lung alveolar type II epithelial cells
    Douglas C Eaton
    Department of Physiology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Proc Am Thorac Soc 1:10-6. 2004
    ..In this article, we discuss the regulation of ENaCs composed of varying subunits and some of the implications of the regulation for normal pulmonary function...
  49. pmc Modification of surfactant protein D by reactive oxygen-nitrogen intermediates is accompanied by loss of aggregating activity, in vitro and in vivo
    Sadis Matalon
    Department of Anesthesiology, University of Alabama, Birmingham, Alabama, USA
    FASEB J 23:1415-30. 2009
    ..Thus, modification of SP-D by reactive oxygen-nitrogen species could contribute to alterations in the structure and function of SP-D at sites of inflammation in vivo...
  50. ncbi request reprint Apical trypsin increases ion transport and resistance by a phospholipase C-dependent rise of Ca2+
    Veronica Swystun
    University of Alabama at Birmingham, Dept of Anesthesiology, AL 35205 3703, USA
    Am J Physiol Lung Cell Mol Physiol 288:L820-30. 2005
    ....
  51. pmc Targeted aerosolized delivery of ascorbate in the lungs of chlorine-exposed rats
    Andreas Bracher
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Aerosol Med Pulm Drug Deliv 25:333-41. 2012
    ..Post-Cl(2) administration of aerosolized ascorbate in rodents decreased lung injury and mortality. However, the extent to which aerosolized ascorbate augments depleted ascorbate stores in distal lung compartments has not been assessed...
  52. pmc Participation of miR-200 in pulmonary fibrosis
    Shanzhong Yang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Am J Pathol 180:484-93. 2012
    ..Thus, the miR-200 family members participate importantly in fibrotic lung diseases and suggest that restoring miR-200 expression in the lungs may represent a novel therapeutic approach in treating pulmonary fibrotic diseases...
  53. pmc Elucidating mechanisms of chlorine toxicity: reaction kinetics, thermodynamics, and physiological implications
    Giuseppe L Squadrito
    Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama 35294 0022, USA
    Am J Physiol Lung Cell Mol Physiol 299:L289-300. 2010
    ....
  54. ncbi request reprint Invited review: biophysical properties of sodium channels in lung alveolar epithelial cells
    Sadis Matalon
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Appl Physiol 93:1852-9. 2002
    ..In this review, we discuss the biophysical properties and occurrence of these various channels and some of the mechanisms for their regulation...
  55. ncbi request reprint Oxidant-antioxidant balance in acute lung injury
    John D Lang
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35294 2172, USA
    Chest 122:314S-320S. 2002
    ..The purpose of this brief chapter is to review the results from various studies demonstrating increased levels of reactive oxygen-nitrogen intermediates in the alveolar spaces of patients with ALI/ARDS...
  56. ncbi request reprint Inhibition of human surfactant protein A function by oxidation intermediates of nitrite
    Ian C Davis
    Department of Anesthesiology, University of Alabama at Birmingham, Birmingham, AL 35205 3703, USA
    Free Radic Biol Med 33:1703-13. 2002
    ....
  57. pmc Assessment of locomotion in chlorine exposed mice by computer vision and neural networks
    Aristotelis S Filippidis
    Department of Anesthesiology, Univ of Alabama at AL, Birmingham, Alabama 35294, USA
    J Appl Physiol 112:1064-72. 2012
    ..This method can be adapted to assess the effectiveness of various therapies following exposure to a variety of chemical and behavioral noxious stimuli...
  58. ncbi request reprint cAMP regulation of Cl(-) and HCO(-)(3) secretion across rat fetal distal lung epithelial cells
    Ahmed Lazrak
    Department of Anesthesiology, University of Alabama at Birmingham, 619 19th Street S, Birmingham, AL 35233, USA
    Am J Physiol Lung Cell Mol Physiol 282:L650-8. 2002
    ..In aggregate, these findings indicate the presence of cAMP-activated Cl(-) and HCO(-)(3) secretion across rat FDLE cells mediated via CFTR...
  59. ncbi request reprint Alveolar macrophage activation after trauma-hemorrhage and sepsis is dependent on NF-kappaB and MAPK/ERK mechanisms
    Doraid Jarrar
    Center for Surgical Research and Departments of Surgery, University of Alabama at Birmingham, 35294, USA
    Am J Physiol Lung Cell Mol Physiol 283:L799-805. 2002
    ..Because enhanced release of inflammatory mediators by AMPhi may contribute to ARDS after severe trauma, inhibition of intracellular signaling pathways represents a target to attenuate organ injury under those conditions...
  60. ncbi request reprint The role of nitric oxide in lung innate immunity: modulation by surfactant protein-A
    Philip O'Reilly
    Department of Medicine, University of Alabama at Birmingham, 35294, USA
    Mol Cell Biochem 234:39-48. 2002
    ..Given its diverse effects on immune function, SP-A may prove to be an effective therapy for both infectious and inflammatory diseases of the lung...
  61. pmc Elevated generation of reactive oxygen/nitrogen species in hantavirus cardiopulmonary syndrome
    Ian C Davis
    Department of Anesthesiology, University of Alabama at Birmingham, 35294, USA
    J Virol 76:8347-59. 2002
    ....
  62. ncbi request reprint Killing of Klebsiella pneumoniae by human alveolar macrophages
    Judy M Hickman-Davis
    Department of Anesthesiology, Division of Nephrology and Nephrology Research Training Center, School of Medicine, University of Alabama at Birmingham, 35294, USA
    Am J Physiol Lung Cell Mol Physiol 282:L944-56. 2002
    ..4. These findings indicate that SP-A mediates pathogen killing by AMs from transplant lungs by stimulating phagocytosis and production of reactive oxygen-nitrogen intermediates...
  63. ncbi request reprint Enhancement of adenovirus-mediated gene transfer in lungs and epithelial cells by EGTA
    Carpantato Myles
    Department of Anesthesiology, Medicine and Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL, USA
    Chest 121:35S. 2002
  64. pmc Surfactant dysfunction in SP-A-/- and iNOS-/- mice with mycoplasma infection
    Judy M Hickman-Davis
    Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Am J Respir Cell Mol Biol 36:103-13. 2007
    ..In addition, SP-A deficiency modifies surfactant aggregate content and lowers the inhibition resistance of LA surfactant in vitro compared with congenic normal mice...
  65. ncbi request reprint Modulation of alveolar fluid clearance by reactive oxygen-nitrogen intermediates
    Weifeng Song
    Am J Physiol Lung Cell Mol Physiol 293:L855-8. 2007
  66. ncbi request reprint Effects of variable concentrations of inhaled nitric oxide and oxygen on the lungs of newborn piglets
    Carolyn Robbins Levine
    CardioPulmonary Research Institute, Winthrop University Hospital, SUNY Stony Brook School of Medicine, Mineola, New York 11501, USA
    Pediatr Pulmonol 34:58-65. 2002
    ..This has important implications in the clinical management of critically ill newborns treated with O(2) and iNO for pulmonary disorders...
  67. ncbi request reprint Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling
    Gokhan M Mutlu
    Division of Pulmonary and Critical Care Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill, USA
    Circ Res 94:1091-100. 2004
    ..These findings indicate that betaAR signaling may not be necessary for basal AFC, and that beta2AR is essential for the adaptive physiological response needed to clear excess fluid from the alveolar airspace of normal and injured lungs...
  68. ncbi request reprint Oleic acid damages ion transport and promotes alveolar edema: the dark side of healthy living
    Sadis Matalon
    Am J Respir Crit Care Med 171:424-5. 2005
  69. pmc Adenosine regulation of alveolar fluid clearance
    Phillip Factor
    Pulmonary, Allergy, and Critical Care Medicine, Columbia University, 639 West 168th Street, New York, NY 10027, USA
    Proc Natl Acad Sci U S A 104:4083-8. 2007
    ....
  70. ncbi request reprint Upregulation of immunoproteasomes by nitric oxide: potential antioxidative mechanism in endothelial cells
    Srigiridhar Kotamraju
    Department of Biophysics and Free Radical Research Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Free Radic Biol Med 40:1034-44. 2006
    ..These results provide new insights on the regulatory mechanisms by which the *NO-mediated immunoproteasome signaling pathway affords cytoprotection in endothelial cells...
  71. ncbi request reprint Vectorial sodium transport across the mammalian alveolar epithelium: it occurs but through which cells?
    Sadis Matalon
    Circ Res 92:348-9. 2003

Research Grants33

  1. NITRIC OXIDE MEDIATED INJURY TO ALVEOLAR EPITHELIUM
    Sadis Matalon; Fiscal Year: 2003
    ..A better understanding of basic mechanisms of innate lung defenses may lead to the development of novel therapies, which may extend to other pathogens. ..
  2. Modulation of innate immunity in lung transplantation
    Sadis Matalon; Fiscal Year: 2005
    ....
  3. Nitric Oxide Modulation of CFTR Expression and Function
    Sadis Matalon; Fiscal Year: 2007
    ....
  4. Prevention and Treatment of Chlorine Gas Induced Injury to the Pulmonary System
    Sadis Matalon; Fiscal Year: 2007
    ....
  5. Mechanisms of ENaC Inhibition by Replicating Influenza Virus: Role of M2 Protein
    Sadis Matalon; Fiscal Year: 2009
    ....
  6. PATHOPHYSIOLOGY OF SUBLETHAL OXYGEN IN INJURED LUNGS
    Sadis Matalon; Fiscal Year: 1993
    ..Completion of these specific aims will provide new and fundamental knowledge on the possible mechanisms of fluid clearance across the alveolar space of both the normal and injured mammalian lung...
  7. PATHOPHYSIOLOGY OF SUBLETHAL OXYGEN IN INJURED LUNGS
    Sadis Matalon; Fiscal Year: 1991
    ....
  8. Mechanisms of ENaC Inhibition by Replicating Influenza Virus: Role of M2 Protein
    Sadis Matalon; Fiscal Year: 2010
    ....