R P Mason

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Oxygenation in a human tumor xenograft: manipulation through respiratory challenge and antibody-directed infarction
    Ralph P Mason
    Department of Radiology, U T Southwestern Medical Center, Dallas, TX 75390, USA
    Adv Exp Med Biol 530:197-204. 2003
  2. pmc Multimodality imaging of hypoxia in preclinical settings
    R P Mason
    Department of Radiology, U T Southwestern Medical Center, Dallas, TX 75390 9058, USA
    Q J Nucl Med Mol Imaging 54:259-80. 2010
  3. ncbi request reprint Non-invasive assessment of kidney oxygenation: a role for BOLD MRI
    R P Mason
    Laboratory of Prognostic Radiology, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9058, USA
    Kidney Int 70:10-1. 2006
  4. ncbi request reprint Quantitative assessment of tumor oxygen dynamics: molecular imaging for prognostic radiology
    Ralph P Mason
    Department of Radiology, U T Southwestern Medical Center, Dallas, Texas, USA
    J Cell Biochem Suppl 39:45-53. 2002
  5. ncbi request reprint Tumor oximetry: demonstration of an enhanced dynamic mapping procedure using fluorine-19 echo planar magnetic resonance imaging in the Dunning prostate R3327-AT1 rat tumor
    S Hunjan
    Advanced Radiological Sciences, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9058, USA
    Int J Radiat Oncol Biol Phys 49:1097-108. 2001
  6. ncbi request reprint Tumor oxygen dynamics with respect to growth and respiratory challenge: investigation of the Dunning prostate R3327-HI tumor
    D Zhao
    Advanced Radiological Sciences, Department of Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9058, USA
    Radiat Res 156:510-20. 2001
  7. ncbi request reprint Physical principles of quantitative nuclear magnetic resonance oximetry
    Vikram D Kodibagkar
    Cancer Imaging Program, Department of Radiology, UT Southwestern, Dallas, TX 75390 9058, USA
    Front Biosci 13:1371-84. 2008
  8. pmc Tumor oxygen dynamics: correlation of in vivo MRI with histological findings
    Dawen Zhao
    Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA
    Neoplasia 5:308-18. 2003
  9. ncbi request reprint Prevention of thiazide-induced hypokalemia without magnesium depletion by potassium-magnesium-citrate
    Clarita V Odvina
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8885, USA
    Am J Ther 13:101-8. 2006
  10. pmc On the potential for molecular imaging with Cerenkov luminescence
    Matthew A Lewis
    Advanced Radiological Sciences, Department of Radiology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9058, USA
    Opt Lett 35:3889-91. 2010

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Oxygenation in a human tumor xenograft: manipulation through respiratory challenge and antibody-directed infarction
    Ralph P Mason
    Department of Radiology, U T Southwestern Medical Center, Dallas, TX 75390, USA
    Adv Exp Med Biol 530:197-204. 2003
    ..This has allowed us both to investigate dynamic response to respiratory challenge (carbogen) and to probe the mechanisms of a new anti-vascular therapy designed to produce tumor-specific infarction...
  2. pmc Multimodality imaging of hypoxia in preclinical settings
    R P Mason
    Department of Radiology, U T Southwestern Medical Center, Dallas, TX 75390 9058, USA
    Q J Nucl Med Mol Imaging 54:259-80. 2010
    ..It should be noted that preclinical methods may have very different criteria for acceptance, as compared with potential investigations for prognostic radiology or predictive biomarkers suitable for use in patients...
  3. ncbi request reprint Non-invasive assessment of kidney oxygenation: a role for BOLD MRI
    R P Mason
    Laboratory of Prognostic Radiology, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9058, USA
    Kidney Int 70:10-1. 2006
    ..In particular, magnetic resonance imaging (MRI) is non-invasive, uses no ionizing radiation, and provides insight into disease development and tissue physiology...
  4. ncbi request reprint Quantitative assessment of tumor oxygen dynamics: molecular imaging for prognostic radiology
    Ralph P Mason
    Department of Radiology, U T Southwestern Medical Center, Dallas, Texas, USA
    J Cell Biochem Suppl 39:45-53. 2002
    ....
  5. ncbi request reprint Tumor oximetry: demonstration of an enhanced dynamic mapping procedure using fluorine-19 echo planar magnetic resonance imaging in the Dunning prostate R3327-AT1 rat tumor
    S Hunjan
    Advanced Radiological Sciences, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9058, USA
    Int J Radiat Oncol Biol Phys 49:1097-108. 2001
    ..CONCLUSIONS: Regional pO(2) was assessed quantitatively and the response of multiple individual tumor regions observed simultaneously with respect to interventions...
  6. ncbi request reprint Tumor oxygen dynamics with respect to growth and respiratory challenge: investigation of the Dunning prostate R3327-HI tumor
    D Zhao
    Advanced Radiological Sciences, Department of Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9058, USA
    Radiat Res 156:510-20. 2001
    ....
  7. ncbi request reprint Physical principles of quantitative nuclear magnetic resonance oximetry
    Vikram D Kodibagkar
    Cancer Imaging Program, Department of Radiology, UT Southwestern, Dallas, TX 75390 9058, USA
    Front Biosci 13:1371-84. 2008
    ..Practical considerations for choice of reporter molecules for in vivo measurements, general methodology and new developments are also described...
  8. pmc Tumor oxygen dynamics: correlation of in vivo MRI with histological findings
    Dawen Zhao
    Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA
    Neoplasia 5:308-18. 2003
    ..These results further validate the utilization of FREDOM to monitor tumor oxygenation and concur with the hypothesis that the level of hypoxia is related to tumor growth rate and poor vascularity...
  9. ncbi request reprint Prevention of thiazide-induced hypokalemia without magnesium depletion by potassium-magnesium-citrate
    Clarita V Odvina
    Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8885, USA
    Am J Ther 13:101-8. 2006
    ..Moreover, KCl is devoid of protective action toward crystallization of stone-forming salts...
  10. pmc On the potential for molecular imaging with Cerenkov luminescence
    Matthew A Lewis
    Advanced Radiological Sciences, Department of Radiology, UT Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9058, USA
    Opt Lett 35:3889-91. 2010
    ....
  11. ncbi request reprint Prognostic radiology: quantitative assessment of tumor oxygen dynamics by MRI
    D Zhao
    Department of Radiology, University of Texas Southwestern Medical Center at Dallas, Texas 75390-9058, USA
    Am J Clin Oncol 24:462-6. 2001
    ..This approach could help to identify patients with hypoxic tumors and indicate the feasibility of manipulating tumor characteristics through adjuvant interventions to improve therapeutic response...
  12. ncbi request reprint Simultaneous intracellular and extracellular pH measurement in the heart by 19F NMR of 6-fluoropyridoxol
    S Hunjan
    Advanced Radiological Sciences, UT Southwestern Medical Center, Dallas, Texas 75235 9058, USA
    Magn Reson Med 39:551-6. 1998
    ..In contrast, respiratory challenge caused a significant increase in pHi. Independent measurements using pH electrodes and 31P NMR confirmed validity of the 19F NMR results...
  13. doi request reprint Molecular imaging of hypoxia
    Kenneth A Krohn
    Department of Radiology, University of Washington, Seattle, Washington 98195 6004, USA
    J Nucl Med 49:129S-48S. 2008
    ..Hypoxia imaging in support of molecular medicine has become an important success story over the last decade and provides a model and some important lessons for development of new molecular imaging probes or techniques...
  14. ncbi request reprint Novel 1H NMR approach to quantitative tissue oximetry using hexamethyldisiloxane
    Vikram D Kodibagkar
    Cancer Imaging Program, Department of Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9058, USA
    Magn Reson Med 55:743-8. 2006
    ..In tumors, altering the inspired gas also produced significant (albeit generally smaller) changes. This new pO2 reporter molecule offers a potentially valuable new tool for investigating pO2 in vivo...
  15. pmc Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death
    B Kucejova
    Department of Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Oncogene 30:2147-60. 2011
    ....
  16. ncbi request reprint Differential oxygen dynamics in two diverse Dunning prostate R3327 rat tumor sublines (MAT-Lu and HI) with respect to growth and respiratory challenge
    Dawen Zhao
    Advanced Radiological Sciences, Department of Radiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9058, USA
    Int J Radiat Oncol Biol Phys 53:744-56. 2002
    ..Since hypoxia may influence tumor response to therapy and prognosis, we have compared oxygenation of tumors known to exhibit differential growth rate and tissue differentiation...
  17. ncbi request reprint Tumor physiologic response to combretastatin A4 phosphate assessed by MRI
    Dawen Zhao
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9058, USA
    Int J Radiat Oncol Biol Phys 62:872-80. 2005
    ..To evaluate the effect of the vascular targeting agent, combretastatin A4 phosphate, on tumor oxygenation compared with vascular perfusion/permeability...
  18. pmc Proton imaging of siloxanes to map tissue oxygenation levels (PISTOL): a tool for quantitative tissue oximetry
    Vikram D Kodibagkar
    Cancer Imaging Program, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    NMR Biomed 21:899-907. 2008
    ..This new method offers a potentially valuable new tool to image pO(2) in vivo for any healthy or diseased state by (1)H MRI...
  19. pmc A 19F-NMR approach using reporter molecule pairs to assess beta-galactosidase in human xenograft tumors in vivo
    Jian Xin Yu
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9058, USA
    NMR Biomed 21:704-12. 2008
    ..Most significantly, hydrolytic activity observed by 19F NMR corresponded to differential activity in lacZ-expressing tumors...
  20. ncbi request reprint Dynamic breast tumor oximetry: the development of prognostic radiology
    Yulin Song
    Cancer Imaging Program, Department of Radiology, University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Technol Cancer Res Treat 1:471-8. 2002
    ....
  21. ncbi request reprint Correlation of tumor oxygen dynamics with radiation response of the dunning prostate R3327-HI tumor
    Dawen Zhao
    Departments of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Radiat Res 159:621-31. 2003
    ....
  22. ncbi request reprint 19F-NMR detection of lacZ gene expression via the enzymic hydrolysis of 2-fluoro-4-nitrophenyl beta-D-galactopyranoside in vivo in PC3 prostate tumor xenografts in the mouse
    Li Liu
    Department of Radiology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, Texas 75390 9058, USA
    FASEB J 21:2014-9. 2007
    ..More importantly, we demonstrate for the first time the ability to differentiate wild-type and lacZ-expressing prostate tumor xenografts in mice using this approach...
  23. pmc Correlation of radiation response with tumor oxygenation in the Dunning prostate R3327-AT1 tumor
    Vincent A Bourke
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, TX, 75390 9058, USA
    Int J Radiat Oncol Biol Phys 67:1179-86. 2007
    ..To investigate the application of pretreatment oxygenation to the AT1 subline of the Dunning R3327 prostate tumor, which is more hypoxic and faster growing than the H1 subline previously studied...
  24. ncbi request reprint Tumor oximetry: comparison of 19F MR EPI and electrodes
    Ralph P Mason
    U T Southwestern Medical Center, Dallas, TX 75390, USA
    Adv Exp Med Biol 530:19-27. 2003
    ..We also compare MR and electrode approaches to monitoring dynamic changes with respect to interventions and demonstrate extension of the MR technique to rat breast tumors...
  25. ncbi request reprint Synthesis and evaluation of novel enhanced gene reporter molecules: detection of beta-galactosidase activity using 19F NMR of trifluoromethylated aryl beta-D-galactopyranosides
    Jianxin Yu
    Department of Radiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    Bioorg Med Chem 14:326-33. 2006
    ..14 ppm) in breast cancer cells transfected to stably express lacZ...
  26. ncbi request reprint Synthesis and evaluation of a novel gene reporter molecule: detection of beta-galactosidase activity using 19F NMR of a fluorinated vitamin B6 conjugate+
    Jianxin Yu
    Department of Radiology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, 75390 9058, USA
    Med Chem 1:255-62. 2005
    ..00 ppm); (b) minimal toxicity for substrate or aglycone; (c) good water solubility; (d) good blood stability; (e) pH responsiveness of aglycone...
  27. ncbi request reprint 19F: a versatile reporter for non-invasive physiology and pharmacology using magnetic resonance
    Jian Xin Yu
    Department of Radiology, The University of Texas Southwestern Medical Center at Dallas, Texas 75390 9058, USA
    Curr Med Chem 12:819-48. 2005
    ..Indeed, the large chemical shift range (approximately 300 ppm) can allow multiple agents to be examined, simultaneously, using NMR spectroscopy or chemical shift selective imaging...
  28. pmc Synthesis and characterization of novel lacZ gene reporter molecules: detection of beta-galactosidase activity by 19F nuclear magnetic resonance of polyglycosylated fluorinated vitamin B6
    Jianxin Yu
    Department of Radiology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9058, USA
    J Med Chem 49:1991-9. 2006
    ..0 approximately 9.4 ppm), minimal toxicity for substrate or aglycon, and good water solubility. However, the differential glycosylation of 12 and 13 appears more advantageous for assessing lacZ gene expression in vivo...
  29. ncbi request reprint Novel NMR platform for detecting gene transfection: synthesis and evaluation of fluorinated phenyl beta-D-galactosides with potential application for assessing LacZ gene expression
    Jianxin Yu
    Department Radiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9058, USA
    Bioconjug Chem 15:1334-41. 2004
    ..This class of molecules presents a new strategy for assaying gene expression with a highly versatile molecular structural platform...
  30. pmc Imaging beta-galactosidase activity in human tumor xenografts and transgenic mice using a chemiluminescent substrate
    Li Liu
    Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 5:e12024. 2010
    ..We now present a novel approach for in vivo detection of beta-galactosidase using optical imaging to detect light emission following administration of the chemiluminescent 1,2-dioxetane substrate Galacto-Light PlusTM...
  31. pmc Dynamic near-infrared optical imaging of 2-deoxyglucose uptake by intracranial glioma of athymic mice
    Heling Zhou
    Department of Radiology, The University of Texas Southwestern Medical Center, Dallas, Texas, United States of America
    PLoS ONE 4:e8051. 2009
    ..We have applied in vivo optical imaging to study dynamic uptake of a near-infrared dye-labeled glucose analogue, 2-deoxyglucose (2-DG) by orthotopic glioma in a mouse model...
  32. pmc High-throughput quantitative bioluminescence imaging for assessing tumor burden
    Angelina Contero
    Cancer Imaging Program, UT Southwestern, Dallas, TX, USA
    Methods Mol Biol 574:37-45. 2009
    ..This chapter will describe routine methods used to support multiple investigators in our small animal imaging resource...
  33. doi request reprint Comparison of 1H blood oxygen level-dependent (BOLD) and 19F MRI to investigate tumor oxygenation
    Dawen Zhao
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9058, USA
    Magn Reson Med 62:357-64. 2009
    ..Significantly, the magnitude of the BOLD response appears to be predictive for residual tumor HFs...
  34. ncbi request reprint Imaging beta-galactosidase activity using 19F chemical shift imaging of LacZ gene-reporter molecule 2-fluoro-4-nitrophenol-beta-D-galactopyranoside
    Vikram D Kodibagkar
    Department of Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9058, USA
    Magn Reson Imaging 24:959-62. 2006
    ..19F CSI studies of enzyme activity and lacZ gene expression in 9L-glioma and MCF7 breast cancer cells are presented, providing further evidence for the utility of OFPNPG as a gene-reporter molecule for future in vivo studies...
  35. ncbi request reprint Novel NMR approach to assessing gene transfection: 4-fluoro-2-nitrophenyl-beta-D-galactopyranoside as a prototype reporter molecule for beta-galactosidase
    Weina Cui
    Department of Radiology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9058, USA
    Magn Reson Med 51:616-20. 2004
    ..Molecular and 19F NMR characteristics of PFONPG in solution, blood, and prostate tumor cells are presented. This prototype molecule facilitates a novel approach for assaying gene activity in vivo...
  36. ncbi request reprint Molecular imaging in prostate cancer
    Jose A Karam
    Department of Urology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9110, USA
    J Cell Biochem 90:473-83. 2003
    ..These techniques are non-invasive and can spare the patient undue morbidity, while potentially providing early diagnosis, accurate follow-up and, finally, valuable prognostic information...
  37. ncbi request reprint Tumor oxygen dynamics: comparison of 19F MR EPI and frequency domain NIR spectroscopy
    Yulin Song
    Joint Graduate Program in Biomedical Engineering, Department of Radiology, UT Southwestern Medical Center, Dallas, TX 75390, USA
    Adv Exp Med Biol 530:225-36. 2003
    ..Generally, changes in vascular sO2 preceded tissue pO2, particularly for smaller tumors...
  38. ncbi request reprint The use of histone deacetylase inhibitor FK228 and DNA hypomethylation agent 5-azacytidine in human bladder cancer therapy
    Jose A Karam
    Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9110, USA
    Int J Cancer 120:1795-802. 2007
    ..FK228 is a potent chemotherapeutic agent for TCC in vivo with minimal undesirable side effects. The elevated p21 level mediated via p53 independent pathway is a hallmark of FK228 mechanism of action...
  39. ncbi request reprint Comparison of BOLD contrast and Gd-DTPA dynamic contrast-enhanced imaging in rat prostate tumor
    Lan Jiang
    Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9058, USA
    Magn Reson Med 51:953-60. 2004
    ..This suggests that the BOLD technique may be a useful tool for investigating interventions (such as drugs) that cause vascular disruption...

Research Grants16

  1. Small Animal Bioluminescence and Fluorescence Imaging System (with 3D capability)
    Ralph Mason; Fiscal Year: 2007
    ..While the reporter gene is only relevant in the preclinical setting, the results achieved should provide insight into optimizing therapy protocols for patients. ..
  2. UT Southwestern Small Animal Imaging Resource
    Ralph Mason; Fiscal Year: 2007
    ..The SW-SAIR will not only provide an important regional resource, but will also represent leadership in imaging innovation at the national and international levels. ..
  3. MAGIC - Magnetic Resonance Assessment of Gene Imaging Constructs
    Ralph Mason; Fiscal Year: 2007
    ..We believe this approach can both become a valuable tool for detecting p-gal activity in vivo and serve as a proof of principle for a novel platform technology adaptable to other reporter genes and endogenous enzymes such as proteases. ..
  4. Southwest In Vivo Cellular and Molecular Imaging Center
    Ralph Mason; Fiscal Year: 2003
    ..Thus, we foresee developments from the bench to the bedside, and viewbox, with iterative loops to define the utility of cancer imaging. ..
  5. Hypoxia and Radiotherapy: Evaluation and Mitigation in Tumors
    Ralph P Mason; Fiscal Year: 2010
    ..We propose to develop this as a robust prognostic test to reveal tumor hypoxia, which could become a valuable tool in stratifying patients for personalized therapy planning in diseases such as prostate cancer. ..