Eliezer Masliah

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Cerebrolysin™ efficacy in a transgenic model of tauopathy: role in regulation of mitochondrial structure
    Edward Rockenstein
    Department of Neurosciences, University of California San Diego, La Jolla, CA, USA
    BMC Neurosci 15:90. 2014
  2. pmc Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5 - implications for dementia with Lewy bodies
    Cassia R Overk
    Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA
    Mol Neurodegener 9:18. 2014
  3. pmc Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's disease
    Brian Spencer
    Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 6:e16575. 2011
  4. pmc Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy
    Leslie Crews
    Department of Pathology, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 5:e9313. 2010
  5. pmc Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy
    Anna E Cartier
    Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 7:e34713. 2012
  6. pmc Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity
    Diana L Price
    Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 5:e14020. 2010
  7. pmc TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease
    Andreas Bender
    Department of Neurology with Friedrich Baur Institute, University of Munich, Munich, Germany
    PLoS ONE 8:e62277. 2013
  8. pmc Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease
    L Crews
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA
    Cell Death Dis 2:e120. 2011
  9. pmc Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease
    Paula Desplats
    Department of Neuroscience, University of California San Diego, 9500 Gilman Dr, MTF 344, La Jolla, CA 92093 0624, USA
    Mol Neurodegener 7:49. 2012
  10. pmc Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H β-synuclein
    Akio Sekigawa
    Division of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Tokyo 156 8506, Japan
    Mol Brain 5:34. 2012

Research Grants

  1. Mechanisms of Neuroprotection in HIV Encephalitis
    Eliezer Masliah; Fiscal Year: 2007
  2. MECHANISMS OF FGF1 NEUROPROTECTION IN HIV ENCEPHALITIS
    Eliezer Masliah; Fiscal Year: 2006
  3. B-Synuclein as a Treatment for Lewy Body Disease
    Eliezer Masliah; Fiscal Year: 2005
  4. B-Synuclein as a Treatment for Lewy Body Disease
    Eliezer Masliah; Fiscal Year: 2004
  5. MECHANISMS OF FGF1 NEUROPROTECTION IN HIV ENCEPHALITIS
    Eliezer Masliah; Fiscal Year: 2004
  6. B-Synuclein as a Treatment for Lewy Body Disease
    Eliezer Masliah; Fiscal Year: 2003
  7. MECHANISMS OF FGF1 NEUROPROTECTION IN HIV ENCEPHALITIS
    Eliezer Masliah; Fiscal Year: 2002
  8. BASIS OF SYNAPTIC PATHOLOGY IN ALZHEIMERS DISEASE
    Eliezer Masliah; Fiscal Year: 1999
  9. SUBCELLULAR BASIS OF SYNAPTIC PATHOLOGY ALZHEIMER DIS
    Eliezer Masliah; Fiscal Year: 1991
  10. BASIS OF SYNAPTIC PATHOLOGY IN ALZHEIMERS DISEASE
    Eliezer Masliah; Fiscal Year: 2001

Detail Information

Publications195 found, 100 shown here

  1. ncbi request reprint Cerebrolysin™ efficacy in a transgenic model of tauopathy: role in regulation of mitochondrial structure
    Edward Rockenstein
    Department of Neurosciences, University of California San Diego, La Jolla, CA, USA
    BMC Neurosci 15:90. 2014
    ..Accordingly, double tg mice expressing mutant Tau under the mThy-1 promoter and GSK3β (to enhance Tau phosphorylation) were treated with CBL and evaluated neuropathologically...
  2. pmc Hippocampal neuronal cells that accumulate α-synuclein fragments are more vulnerable to Aβ oligomer toxicity via mGluR5 - implications for dementia with Lewy bodies
    Cassia R Overk
    Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA
    Mol Neurodegener 9:18. 2014
    ..In this context, the main objective of the present study was to investigate the role of mGluR5 as a mediator of the neurotoxic effects of α-syn and Aβ in the hippocampus...
  3. pmc Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's disease
    Brian Spencer
    Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 6:e16575. 2011
    ..Thus, the addition of the ApoB transport domain to the secreted neprilysin generated a non-invasive therapeutic approach that may be a potential treatment in patients with AD...
  4. pmc Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathy
    Leslie Crews
    Department of Pathology, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 5:e9313. 2010
    ..For this reason, we sought to examine the expression levels of members of the autophagy pathway in brains of patients with DLB and Alzheimer's Disease (AD) and in alpha-synuclein transgenic mice...
  5. pmc Differential effects of UCHL1 modulation on alpha-synuclein in PD-like models of alpha-synucleinopathy
    Anna E Cartier
    Department of Neurosciences, School of Medicine, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 7:e34713. 2012
    ....
  6. pmc Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity
    Diana L Price
    Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 5:e14020. 2010
    ..These results highlight the therapeutic importance of mGluR5 antagonists in alpha-synucleinopathies...
  7. pmc TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease
    Andreas Bender
    Department of Neurology with Friedrich Baur Institute, University of Munich, Munich, Germany
    PLoS ONE 8:e62277. 2013
    ..Our results suggest that alterations in the mitochondrial protein transport machinery might contribute to mitochondrial impairment in α-Synucleinopathies...
  8. pmc Modulation of aberrant CDK5 signaling rescues impaired neurogenesis in models of Alzheimer's disease
    L Crews
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA
    Cell Death Dis 2:e120. 2011
    ..Moreover, potential therapeutic approaches could focus on modulating the aberrant activity of CDK5 to target the neurogenic and neurodegenerative alterations in AD...
  9. pmc Combined exposure to Maneb and Paraquat alters transcriptional regulation of neurogenesis-related genes in mice models of Parkinson's disease
    Paula Desplats
    Department of Neuroscience, University of California San Diego, 9500 Gilman Dr, MTF 344, La Jolla, CA 92093 0624, USA
    Mol Neurodegener 7:49. 2012
    ..While PD is characterized by neuronal loss in the substantia nigra, we previously showed that accumulation of α-synuclein in the limbic system contributes to neurodegeneration by interfering with adult neurogenesis...
  10. pmc Distinct mechanisms of axonal globule formation in mice expressing human wild type α-synuclein or dementia with Lewy bodies-linked P123H β-synuclein
    Akio Sekigawa
    Division of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Tokyo 156 8506, Japan
    Mol Brain 5:34. 2012
    ....
  11. pmc Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer
    Jerel Fields
    Department of Pathology, University of California San Diego, La Jolla, CA 92093, USA
    J Neurovirol 19:89-101. 2013
    ..These data indicate differential alterations in the autophagy pathway in young versus aged HIVE patients and that autophagy reactivation may ameliorate the neurodegenerative phenotype in these patients...
  12. pmc Deficiency of terminal complement pathway inhibitor promotes neuronal tau pathology and degeneration in mice
    Markus Britschgi
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, 1201 Welch Road MSLS Bldg, Rm P208, Stanford, CA 94305 5489, USA
    J Neuroinflammation 9:220. 2012
    ..Because tauopathies are accompanied by neuroinflammation and the complement cascade forms a key innate immune pathway, we asked whether the complement system has a role in the development of tau pathology...
  13. pmc Preventive immunization of aged and juvenile non-human primates to β-amyloid
    Julia Kofler
    Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Neuroinflammation 9:84. 2012
    ....
  14. pmc Time course and progression of wild type α-synuclein accumulation in a transgenic mouse model
    David Amschl
    QPS Austria GmbH, Parkring 12, Grambach 8074, Austria
    BMC Neurosci 14:6. 2013
    ..For this purpose we investigated the time course of behavioral deficits and neuropathology in PDGF-β human wild type α-Syn transgenic mice (D-Line) between 3 and 12 months of age...
  15. pmc Prion infection promotes extensive accumulation of α-synuclein in aged human α-synuclein transgenic mice
    Eliezer Masliah
    Department of Neuroscience, University of California, San Diego, La Jolla, CA, USA
    Prion 6:184-90. 2012
    ..Taken together, these studies support the notion that PrP(Sc) directly or indirectly promotes α-synuclein pathology...
  16. pmc Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neurons
    Yofre Cabeza-Arvelaiz
    Department of Pathology and Environmental Health Sciences, The Geffen School of Medicine and School of Public Health, University of California, Los Angeles, 650 Charles E, Young Dr S, CHS 71 295, Los Angeles, CA 90095, USA
    Mol Neurodegener 6:83. 2011
    ..Therefore it is of interest to understand how overexpression of SNCA affects neuronal function in regions not directly targeted for neurodegeneration in PD...
  17. pmc Neuromelanin, neurotransmitter status and brainstem location determine the differential vulnerability of catecholaminergic neurons to mitochondrial DNA deletions
    Matthias Elstner
    Department of Neurology with Friedrich Baur Institute, Ludwig Maximilians University, 81377 Munich, Germany
    Mol Brain 4:43. 2011
    ....
  18. ncbi request reprint The pharmacology of neurotrophic treatment with Cerebrolysin: brain protection and repair to counteract pathologies of acute and chronic neurological disorders
    E Masliah
    Department of Neurosciences, University of California, La Jolla, CA, USA
    Drugs Today (Barc) 48:3-24. 2012
    ..This section summarizes the most relevant data on the pharmacology of Cerebrolysin obtained from in vitro assays (biochemical and cell cultures) and in vivo animal models of acute and chronic neurological disorders...
  19. pmc Role of synucleins in Alzheimer's disease
    Leslie Crews
    Department of Neurosciences, University of California San Diego, La Jolla, CA 92093 0624, USA
    Neurotox Res 16:306-17. 2009
    ..Thus, better understanding the steps involved in the process of Abeta and alpha-syn aggregation is important in order to develop intervention strategies that might prevent or reverse the accumulation of toxic proteins in AD...
  20. pmc Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregation
    Fanjun Meng
    Department of Pathology and Anatomical Sciences, Center for Translational Neuroscience, University of Missouri Columbia School of Medicine, Columbia, MO, USA
    Mol Neurodegener 6:34. 2011
    ..abstract:..
  21. pmc NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegeneration
    Young Don Kwak
    Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, 874 Union Avenue, Memphis TN, 38163, USA
    Mol Neurodegener 5:49. 2010
    ..However the molecular signals and mechanism underlying PTEN loss are unknown...
  22. pmc The biochemical aftermath of anti-amyloid immunotherapy
    Chera L Maarouf
    The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
    Mol Neurodegener 5:39. 2010
    ..These patients were compared to 6 non-immunized AD cases and 5 non-demented control (NDC) cases...
  23. pmc APP transgenic modeling of Alzheimer's disease: mechanisms of neurodegeneration and aberrant neurogenesis
    Leslie Crews
    Department of Pathology, University of California, San Diego, La Jolla, CA, USA
    Brain Struct Funct 214:111-26. 2010
    ..Promising results have been obtained utilizing APP tg models of AD to develop therapies including the use of beta- and gamma-secretase inhibitors, immunization, and stimulating neurogenesis...
  24. pmc Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's disease
    Tiffany Kaul
    Department of Biochemistry and Molecular and Cell Biology, University of California San Diego, La Jolla, California, USA
    BMC Neurosci 12:79. 2011
    ..The current studies were undertaken to analyze the distribution of tauopathy in different brain regions in a widely used mouse model of PD, the α-Syn overexpressing mouse...
  25. pmc A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDS
    Robert A Fuller
    Massachusetts General Hospital NMR Center and Neuroradiology Division, Harvard Medical School, Charlestown, MA, USA
    BMC Neurosci 5:10. 2004
    ..Our goal was to undertsand the dynamics of cerebral injury by performing a longitudinal in vivo 1H MRS study of the SIV/macaque model of neuroAIDS...
  26. pmc Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120
    Dianne Langford
    Department of Pathology, University of California, San Diego, La Jolla, CA, USA
    BMC Neurosci 6:8. 2005
    ..We hypothesized that treatment of human umbilical vein endothelial cells (HUVEC) with FGF2 would protect the cells from gp120-mediated toxicity via endothelial cell survival signalling...
  27. ncbi request reprint The role of synaptic proteins in Alzheimer's disease
    E Masliah
    School of Medicine, Departments of Neurosciences and Pathology, University of California, San Diego, La Jolla, California 92093 0624, USA
    Ann N Y Acad Sci 924:68-75. 2000
    ....
  28. pmc beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease
    E Masliah
    Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 98:12245-50. 2001
    ..Therefore, treatments that block the production or accumulation of beta-amyloid peptides could benefit a broader spectrum of disorders than previously anticipated...
  29. ncbi request reprint Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease
    Eliezer Masliah
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    Neuron 46:857-68. 2005
    ..These results suggest that vaccination is effective in reducing neuronal accumulation of halpha-syn aggregates and that further development of this approach might have a potential role in the treatment of LBD...
  30. ncbi request reprint Functional role of TGF beta in Alzheimer's disease microvascular injury: lessons from transgenic mice
    E Masliah
    Department of Neurosciences, University of California San Diego, La Jolla, CA 92093 0624, USA
    Neurochem Int 39:393-400. 2001
    ..In this regard, further elucidation of the signal pathways by which TGF-beta exerts its effect in AD might lead to specific targets for further therapeutic intervention...
  31. pmc Recent advances in the development of immunotherapies for tauopathies
    Kiren Ubhi
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Exp Neurol 230:157-61. 2011
    ..This commentary will discuss the use of immunotherapy for AD, focusing on tau immunotherapy in the context of recent reports on the use of tau phospho-peptides in transgenic models of tau pathology...
  32. pmc Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease
    Eliezer Masliah
    Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 6:e19338. 2011
    ..These results suggest that passive immunization with monoclonal antibodies against the CT of α-syn may be of therapeutic relevance in patients with PD and DLB...
  33. pmc Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disorders
    Leslie Crews
    Department of Neurosciences University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093 0624, USA
    Mol Neurodegener 6:67. 2011
    ..abstract:..
  34. ncbi request reprint Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease
    E Masliah
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA
    Neurology 64:129-31. 2005
    ..This case illustrates the effects of an Abeta-based immunization on AD pathogenesis in the absence of overt meningoencephalitis and leukoencephalopathy...
  35. ncbi request reprint Development of new treatments for Parkinson's disease in transgenic animal models: a role for beta-synuclein
    Eliezer Masliah
    Neurotoxicology 23:461-8. 2002
    ..Such an anti-amyloidogenic property of beta-synuclein might also provide a novel strategy for the treatment of neurodegenerative disorders...
  36. ncbi request reprint Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease
    E Masliah
    Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA, USA
    Neurology 56:127-9. 2001
    ..Levels of synaptotagmin and GAP43 were unchanged in mild AD, but cases with CDR of >1 had a progressive decrement in these synaptic proteins. Thus, synaptic injury in frontal cortex is an early event in AD...
  37. ncbi request reprint Synaptic remodeling during aging and in Alzheimer's disease
    Eliezer Masliah
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
    J Alzheimers Dis 9:91-9. 2006
    ..In this context, the main objective of this manuscript is to discuss the findings of our 1993 study in light of more recent studies in aging, synapses and Alzheimer's disease...
  38. ncbi request reprint Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders
    E Masliah
    Department of Neurosciences, Department of Pathology, University of California San Diego, La Jolla, CA 92093 0624, USA
    Science 287:1265-9. 2000
    ..These results suggest that accumulation of wild-type alpha-synuclein may play a causal role in Parkinson's disease and related conditions...
  39. ncbi request reprint Patterns of gene dysregulation in the frontal cortex of patients with HIV encephalitis
    Eliezer Masliah
    Department of Pathology, University of California San Diego, La Jolla, CA 92093 6232, USA
    J Neuroimmunol 157:163-75. 2004
    ....
  40. pmc Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins
    Emiley Pham
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA
    FEBS J 277:3051-67. 2010
    ..In conclusion, this study suggests that the presence of a subpopulation of amyloid-beta oligomers in the brains of patients with Alzheimer's disease might be related to alterations in selected synaptic proteins and cognitive impairment...
  41. pmc Neurofibrillary and neurodegenerative pathology in APP-transgenic mice injected with AAV2-mutant TAU: neuroprotective effects of Cerebrolysin
    Kiren Ubhi
    Department of Neurosciences, School of Medicine, University of California, La Jolla, San Diego, CA 92093 0624, USA
    Acta Neuropathol 117:699-712. 2009
    ..This study supports the concept that the neuroprotective effects of CBL may involve the reduction of TAU phosphorylation by regulating kinase activity...
  42. ncbi request reprint Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's disease
    Edward Rockenstein
    Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, California 92093 0624, USA
    J Neurosci Res 83:1252-61. 2006
    ..This study clarifies the mechanisms through which Cerebrolysin might reduce Abeta production and deposition in AD and further supports the importance of this compound in the potential treatment of early AD...
  43. pmc Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic mice
    Brian Spencer
    Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA
    BMC Neurosci 9:109. 2008
    ..However the effects of long-term neprilysin gene transfer on other aspects of Abeta associated pathology have not been explored yet in APP transgenic mice...
  44. pmc Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases
    Igor F Tsigelny
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America
    PLoS ONE 3:e3135. 2008
    ..However the molecular characteristics and consequences of these interactions are not completely clear...
  45. pmc Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disorders
    Yeon Joo Kang
    Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
    Ann Neurol 68:342-52. 2010
    ..Here, we report that chronic treatment with erythropoietin (EPO) and insulin-like growth factor-I (IGF-I) protects against HIV/gp120-mediated neuronal damage in culture and in vivo...
  46. ncbi request reprint Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylation
    Edward Rockenstein
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 27:1981-91. 2007
    ....
  47. pmc Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease
    John B Rose
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
    J Neurosci 29:1115-25. 2009
    ..This function of NEP represents a unique example of a proteolytic enzyme with dual action, namely, degradation of Abeta as well as processing of NPY...
  48. pmc Longer term improvement in neurocognitive functioning and affective distress among methamphetamine users who achieve stable abstinence
    Jennifer E Iudicello
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92103, USA
    J Clin Exp Neuropsychol 32:704-18. 2010
    ..These results suggest partial recovery of neuropsychological functioning and improvement in affective distress upon sustained abstinence from MA that may extend beyond a year or more...
  49. pmc Neurocognitive consequences of HIV infection in older adults: an evaluation of the "cortical" hypothesis
    J Cobb Scott
    HIV Neurobehavioral Research Center, Department of Psychiatry, University of California San Diego, San Diego, CA, USA
    AIDS Behav 15:1187-96. 2011
    ..Thus, in this sample of older HIV-infected individuals, the combined effects of HIV and aging do not appear to result in a "cortical" pattern of cognitive deficits...
  50. pmc Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases
    Brian Spencer
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
    J Neurosci 29:13578-88. 2009
    ..Thus, beclin 1 plays an important role in the intracellular degradation of alpha-syn either directly or indirectly through the autophagy pathway and may present a novel therapeutic target for LBD/PD...
  51. ncbi request reprint Effects of Cerebrolysin on neurogenesis in an APP transgenic model of Alzheimer's disease
    Edward Rockenstein
    Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, CA, 92093 0624, USA
    Acta Neuropathol 113:265-75. 2007
    ..The improved neurogenesis in the hippocampus of CBL-treated APP tg mice might play an important role in enhancing synaptic formation and memory acquisition...
  52. ncbi request reprint High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer disease
    Edward Rockenstein
    Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, California 92093 0624, USA
    J Biol Chem 280:32957-67. 2005
    ..Thus, inhibiting BACE1 may block not only Abeta-dependent but also Abeta-independent pathogenic mechanisms...
  53. pmc Beneficial effects of a neurotrophic peptidergic mixture persist for a prolonged period following treatment interruption in a transgenic model of Alzheimer's disease
    Edward Rockenstein
    Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, California 92093 0624, USA
    J Neurosci Res 89:1812-21. 2011
    ....
  54. pmc Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1
    Anna E Cartier
    Section of Neurobiology, Department of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0347, USA
    J Neurosci 29:7857-68. 2009
    ..These findings point to a significant role of UCH-L1 in synaptic remodeling, most likely by modulating free monomeric ubiquitin levels in an activity-dependent manner...
  55. pmc Neurotoxic effects of the HCV core protein are mediated by sustained activation of ERK via TLR2 signaling
    Amy D Paulino
    Department of Neurosciences, University of California San Diego, La Jolla, CA 92093 0624, USA
    J Neurovirol 17:327-40. 2011
    ..These pathways provide novel targets for development of neuroprotective treatments for HCV involvement of the CNS...
  56. pmc Increased frequency of alpha-synuclein in the substantia nigra in human immunodeficiency virus infection
    Negar Khanlou
    Department of Pathology and Laboratory Medicine, Division of Neuropathology, David Geffen School of Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, California, USA
    J Neurovirol 15:131-8. 2009
    ..The increased prevalence of alpha-synuclein and beta-amyloid in the brains of older HIV-infected individuals may predict an increased risk of developing neurodegenerative disease...
  57. ncbi request reprint Neprilysin regulates amyloid Beta peptide levels
    Robert A Marr
    Laboratory of Genetics, Salk Institute, La Jolla, CA 92037, USA
    J Mol Neurosci 22:5-11. 2004
    ..These studies provide the impetus for further investigating of the use of NEP in a gene transfer therapy paradigm to prevent the accumulation of Abeta and prevent or delay the onset of Alzheimer's disease...
  58. ncbi request reprint Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model
    Oded Singer
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 8:1343-9. 2005
    ....
  59. ncbi request reprint Altered p59Fyn kinase expression accompanies disease progression in Alzheimer's disease: implications for its functional role
    Gilbert J Ho
    Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0624, USA
    Neurobiol Aging 26:625-35. 2005
    ..Taken together, these findings suggest that alterations in Fyn localization might be associated with neurofibrillary pathology and synapse loss in AD...
  60. pmc Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies
    Andrew O Koob
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA
    Exp Neurol 221:267-74. 2010
    ....
  61. pmc Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo
    Edward Rockenstein
    1 Department of Neurosciences, University of California San Diego, La Jolla, CA, USA
    Brain 137:1496-513. 2014
    ..This oligomer-prone model might be useful for evaluating therapies directed at oligomer reduction. ..
  62. ncbi request reprint Neprilysin gene transfer reduces human amyloid pathology in transgenic mice
    Robert A Marr
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 23:1992-6. 2003
    ..These data further support a role for neprilysin in regulating cerebral amyloid deposition and suggest that gene transfer approaches might have potential for the development of alternative therapies for Alzheimer's disease...
  63. pmc Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic mice
    Leslie Crews
    Departments of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
    J Neurosci 28:4250-60. 2008
    ..Together, these results suggest that accumulation of alpha-syn might impair survival of NPCs by interfering with the Notch signaling pathway. Similar mechanisms could be at play in PD and Lewy body disease...
  64. ncbi request reprint Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy
    Clifford W Shults
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
    J Neurosci 25:10689-99. 2005
    ..Together, these studies support the contention that accumulation of alpha-syn in oligodendrocytes promotes neurodegeneration and recapitulates several of the key functional and neuropathological features of MSA...
  65. pmc Increased accumulation of intraneuronal amyloid beta in HIV-infected patients
    Cristian L Achim
    Department of Psychiatry, University of California, San Diego, CA 92093 0624, USA
    J Neuroimmune Pharmacol 4:190-9. 2009
    ..These findings suggest that long-term survival with HIV might interfere with clearance of proteins such as Abeta and worsen neuronal damage and cognitive impairment in this population...
  66. pmc Neurodegeneration in a transgenic mouse model of multiple system atrophy is associated with altered expression of oligodendroglial-derived neurotrophic factors
    Kiren Ubhi
    Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, California 92093 0624, USA
    J Neurosci 30:6236-46. 2010
    ..These results suggest a mechanism in which alphasyn expression in oligodendrocytes impacts on the trophic support provided by these cells for neurons, perhaps contributing to neurodegeneration...
  67. pmc The semantic relatedness of cue-intention pairings influences event-based prospective memory failures in older adults with HIV infection
    Steven Paul Woods
    HIV Neurobehavioral Research Center, Department of Psychiatry, University of California, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 32:398-407. 2010
    ....
  68. pmc Methamphetamine use parameters do not predict neuropsychological impairment in currently abstinent dependent adults
    Mariana Cherner
    Department of Psychiatry, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0847, USA
    Drug Alcohol Depend 106:154-63. 2010
    ..The apparent lack of correspondence between substance use parameters and cognitive impairment suggests the need for further study of individual differences in vulnerability to the neurotoxic effects of methamphetamine...
  69. pmc Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic mice
    Corinne G Jolivalt
    Department of Pathology, University of California San Diego, La Jolla, CA 92093 0612, USA
    Exp Neurol 223:422-31. 2010
    ....
  70. pmc Neurobehavioral effects of human immunodeficiency virus infection among former plasma donors in rural China
    Robert K Heaton
    HIV Neurobehavioral Research Center HNRC, Department of Psychiatry, University of California at San Diego, San Diego, California 92093 0603, USA
    J Neurovirol 14:536-49. 2008
    ..These findings indicate that HAND is likely to be an important feature of HIV infection in developing countries, underscoring the need for international efforts to develop CNS-relevant treatments...
  71. doi request reprint alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson disease
    Kohichi Kawahara
    Department of Neurosciences, School of Medicine, University of California at San Diego, La Jolla, California 92039 0624, USA
    J Biol Chem 283:6979-87. 2008
    ..These studies provide a new perspective on the potential nature of pathogenic alpha-synuclein and parkin interactions in Parkinson disease...
  72. ncbi request reprint Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice
    Jeannie Chin
    Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, California 94141 9100, USA
    J Neurosci 24:4692-7. 2004
    ..We conclude that Fyn-dependent pathways are critical in AD-related synaptotoxicity and that the pathogenesis of hAPP/Abeta-induced neuronal alterations may be mechanistically heterogenous...
  73. pmc Glycogen synthase kinase-3beta (GSK-3beta) inhibitors AR-A014418 and B6B3O prevent human immunodeficiency virus-mediated neurotoxicity in primary human neurons
    Timothy B Nguyen
    Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, California 92093 0603, USA
    J Neurovirol 15:434-8. 2009
    ..These data support a role for GSK3beta as a potential therapeutic target and may have important clinical implications for treatment of HIV-associated neurocognitive disorder...
  74. pmc Intraindividual variability in HIV infection: evidence for greater neurocognitive dispersion in older HIV seropositive adults
    Erin E Morgan
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    Neuropsychology 25:645-54. 2011
    ..To our knowledge, no studies have yet examined dispersion in an aging HIV-infected sample...
  75. ncbi request reprint The role of mitochondrial alterations in the combined toxic effects of human immunodeficiency virus Tat protein and methamphetamine on calbindin positive-neurons
    Dianne Langford
    Department of Pathology, University of California, San Diego, La Jolla, California 92093 0624, USA
    J Neurovirol 10:327-37. 2004
    ..In combination, Tat and METH may increase cell injury and death, thereby enhancing brain metabolic disturbances observed in HIV-positive METH users in clinical populations...
  76. pmc Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium flux
    Roberta Marongiu
    Department of Neurosciences, University of California, San Diego, La Jolla, California, USA
    J Neurochem 108:1561-74. 2009
    ..Moreover, these studies support an important function for Pink1 in regulating mitochondrial activity under stress conditions...
  77. pmc Spontaneous strategy use protects against visual working memory deficits in older adults infected with HIV
    Steven Paul Woods
    Department of Psychiatry, University of California San Diego, La Jolla, USA
    Arch Clin Neuropsychol 25:724-33. 2010
    ....
  78. pmc A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration
    David A Scott
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 30:8083-95. 2010
    ..Collectively the data suggest a previously unknown cascade of events where pathologic alpha-synuclein leads to a loss of a number of critical presynaptic proteins, thereby inducing functional synaptic deficits...
  79. pmc Is prospective memory a dissociable cognitive function in HIV infection?
    Saurabh Gupta
    Department of Psychiatry, University of California, San Diego, CA 92103, USA
    J Clin Exp Neuropsychol 32:898-908. 2010
    ..The results of this study lend further evidence to the dissociability of ProM in HIV infection, are consistent with prior studies in healthy adults, and contribute to a growing literature on the construct validity of ProM in HIV disease...
  80. pmc Axonopathy in an α-synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated α-synuclein
    Dora Games
    Neotope Biosciences, South San Francisco, California, USA
    Am J Pathol 182:940-53. 2013
    ..These results show that neuritic dystrophy is a prominent pathologic feature of the mThy1-α-syn tg model and suggest that CT α-syn might play an important role in the process of axonal damage in these mice as well as in DLB and PD...
  81. doi request reprint Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus
    Beate Winner
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 32:16906-16. 2012
    ..The current work provides novel insights into the role of α-synuclein in adult hippocampal neurogenesis...
  82. ncbi request reprint Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein
    Emily Van Uden
    Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, California 92093 0624, USA
    J Neurosci 22:9298-304. 2002
    ..Together, these results further support the contention that LRP and other lipoprotein receptors might be neuroprotective against Abeta toxicity and that this receptor might play an integral role in Abeta clearance...
  83. pmc Regional comparison of the neurogenic effects of CNTF-derived peptides and cerebrolysin in AβPP transgenic mice
    Edward Rockenstein
    University of California, San Diego, Neurosciences Department, La Jolla, CA 92093 0624, USA
    J Alzheimers Dis 27:743-52. 2011
    ..These results are consistent with a potential therapeutic relevance for Peptides 6 and 6A in AD and other disorders characterized by neurogenic deficits...
  84. pmc Prospective memory deficits are associated with unemployment in persons living with HIV infection
    Steven Paul Woods
    Department of Psychiatry, University of California, San Diego, USA
    Rehabil Psychol 56:77-84. 2011
    ..To determine whether deficits in prospective memory (i.e., "remembering to remember") confer an increased risk of unemployment in individuals living with chronic HIV infection...
  85. pmc Neuropathology of dementia with Lewy bodies in advanced age: a comparison with Alzheimer disease
    Kiren Ubhi
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA
    Neurosci Lett 485:222-7. 2010
    ..Taken together these results suggest that the oldest old with DLB might represent a distinct group...
  86. pmc Cytochrome P450-2D6 extensive metabolizers are more vulnerable to methamphetamine-associated neurocognitive impairment: preliminary findings
    Mariana Cherner
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0847, USA
    J Int Neuropsychol Soc 16:890-901. 2010
    ..This preliminary study is the first to suggest that efficient meth metabolism is associated with worse neurocognitive outcomes in humans, and implicates the products of oxidative metabolism of meth as a possible source of brain injury...
  87. pmc Correlation of major depressive disorder symptoms with FKBP5 but not FKBP4 expression in human immunodeficiency virus-infected individuals
    Erick T Tatro
    Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0603, USA
    J Neurovirol 16:399-404. 2010
    ..Change in FKBP4 expression did not correlate with changes in clinical or depression measurements. Higher FKBP5 expression correlated with greater symptom change for GG carriers of rs3800373...
  88. pmc Demographically corrected norms for African Americans and Caucasians on the Hopkins Verbal Learning Test-Revised, Brief Visuospatial Memory Test-Revised, Stroop Color and Word Test, and Wisconsin Card Sorting Test 64-Card Version
    Marc A Norman
    Department of Psychiatry, University of California, San Diego, CA, USA
    J Clin Exp Neuropsychol 33:793-804. 2011
    ..Findings support the need to consider extended demographic contributions to neuropsychological test performance in clinical and research settings...
  89. pmc Misremembering future intentions in methamphetamine-dependent individuals
    Jennifer E Iudicello
    Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California, San Diego, CA, USA
    Clin Neuropsychol 25:269-86. 2011
    ..Findings suggest that individuals with MA dependence experience difficulty in the strategic components involved in the retrieval of future intentions and are discussed with regard to their implications for everyday functioning...
  90. ncbi request reprint Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's disease
    Makoto Hashimoto
    Department of Neuroscience, University of California at San Diego, La Jolla, California 92093 0624, USA
    J Neurochem 85:1468-79. 2003
    ..Thus, the caveolin-1/ERK pathway could be a therapeutic target for the alpha-synuclein-related neurodegenerative disorders...
  91. pmc HIV-associated prospective memory impairment in the laboratory predicts failures on a semi-naturalistic measure of health care compliance
    Jennifer B Zogg
    Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Clin Neuropsychol 24:945-62. 2010
    ..g., depression). Results support the hypothesis that ProM plays a unique role in compliance with health care instructions for HIV disease management and may inform interventions designed to improve treatment outcomes...
  92. pmc Visuospatial deficits predict rate of cognitive decline in autopsy-verified dementia with Lewy bodies
    Joanne M Hamilton
    Department of Neurosciences, University of California, USA
    Neuropsychology 22:729-37. 2008
    ....
  93. ncbi request reprint Patterns of selective neuronal damage in methamphetamine-user AIDS patients
    Dianne Langford
    Department of Pathology, University of California at San Francisco, La Jolla, CA 92093 0624, USA
    J Acquir Immune Defic Syndr 34:467-74. 2003
    ..In combination, METH and HIV may increase neuronal cell injury and death, thereby enhancing brain metabolic disturbances observed in clinical populations of HIV-positive METH abusers...
  94. ncbi request reprint Cortical and subcortical neurodegeneration is associated with HIV neurocognitive impairment
    David J Moore
    HIV Neurobehavioral Research Center and University of California, San Diego, California 92161, USA
    AIDS 20:879-87. 2006
    ..To determine the association of markers of regional neurodegeneration (ND) at autopsy to degree of neurocognitive impairment in persons with HIV...
  95. ncbi request reprint Abeta1-42 promotes cholinergic sprouting in patients with AD and Lewy body variant of AD
    E Masliah
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA emasliah ucsd edu
    Neurology 61:206-11. 2003
    ....
  96. ncbi request reprint Transgenic models to assess the pathogenic actions of cytokines in the central nervous system
    I L Campbell
    Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037, USA
    Mol Psychiatry 2:125-9. 1997
    ..Thus, expression of specific cytokines alone in the intact CNS results in unique neuropathological alterations and functional impairments, thereby directly implicating these mediators in the pathogenesis of CNS disease...
  97. ncbi request reprint Transgenic animal models of neurodegenerative diseases and their application to treatment development
    Edward Rockenstein
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
    Adv Drug Deliv Rev 59:1093-102. 2007
    ....
  98. ncbi request reprint Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters
    Edward Rockenstein
    Department of Neurosciences, University of California San Diego, La Jolla, California 92093 0624, USA
    J Neurosci Res 68:568-78. 2002
    ....
  99. pmc Severe, demyelinating leukoencephalopathy in AIDS patients on antiretroviral therapy
    T Dianne Langford
    Department of Pathology, University of California, San Diego, CA, USA
    AIDS 16:1019-29. 2002
    ....
  100. ncbi request reprint Age at onset is associated with disease severity in Lewy body variant and Alzheimer's disease
    Gilbert J Ho
    Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093 0624, USA
    Neuroreport 13:1825-8. 2002
    ..Taken together, these results suggest that for both LBV and AD, earlier age at onset may predict a more aggressive disease course...
  101. ncbi request reprint Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease
    Gorazd B Stokin
    Howard Hughes Medical Institute and Department of Cellular and Molecular Medicine, School of Medicine, University of California San Diego UCSD, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Science 307:1282-8. 2005
    ..Reductions in microtubule-dependent transport may stimulate proteolytic processing of beta-amyloid precursor protein, resulting in the development of senile plaques and Alzheimer's disease...

Research Grants26

  1. Mechanisms of Neuroprotection in HIV Encephalitis
    Eliezer Masliah; Fiscal Year: 2007
    ..Together these studies will help to elucidate the role of the CDK5 pathway in neurodegeneration in patients with HIVE and help at developing new neuroprotective treatments. ..
  2. MECHANISMS OF FGF1 NEUROPROTECTION IN HIV ENCEPHALITIS
    Eliezer Masliah; Fiscal Year: 2006
    ..Clarification of the mechanisms by which FGF1 protects neurons against HIV will provide a potential target for the development of new treatment directed at ameliorating the neuronal damage to in AIDS patients with cognitive impairment. ..
  3. B-Synuclein as a Treatment for Lewy Body Disease
    Eliezer Masliah; Fiscal Year: 2005
    ..abstract_text> ..
  4. B-Synuclein as a Treatment for Lewy Body Disease
    Eliezer Masliah; Fiscal Year: 2004
    ..abstract_text> ..
  5. MECHANISMS OF FGF1 NEUROPROTECTION IN HIV ENCEPHALITIS
    Eliezer Masliah; Fiscal Year: 2004
    ..Clarification of the mechanisms by which FGF1 protects neurons against HIV will provide a potential target for the development of new treatment directed at ameliorating the neuronal damage to in AIDS patients with cognitive impairment. ..
  6. B-Synuclein as a Treatment for Lewy Body Disease
    Eliezer Masliah; Fiscal Year: 2003
    ..abstract_text> ..
  7. MECHANISMS OF FGF1 NEUROPROTECTION IN HIV ENCEPHALITIS
    Eliezer Masliah; Fiscal Year: 2002
    ..Clarification of the mechanisms by which FGF1 protects neurons against HIV will provide a potential target for the development of new treatment directed at ameliorating the neuronal damage to in AIDS patients with cognitive impairment. ..
  8. BASIS OF SYNAPTIC PATHOLOGY IN ALZHEIMERS DISEASE
    Eliezer Masliah; Fiscal Year: 1999
    ..These studies will help to better understand the mechanisms of synaptic pathology in AD and to develop potential neuroprotective agents that will operate by enhancing the GT activity. ..
  9. SUBCELLULAR BASIS OF SYNAPTIC PATHOLOGY ALZHEIMER DIS
    Eliezer Masliah; Fiscal Year: 1991
    ..We expect that this lesion and neurotoxin combination will reproduce, in the rodent model, the widespread dystrophic alterations observed in AD and provide information about the pathogenesis of the synaptic alterations observed in AD...
  10. BASIS OF SYNAPTIC PATHOLOGY IN ALZHEIMERS DISEASE
    Eliezer Masliah; Fiscal Year: 2001
    ..These studies will help to better understand the mechanisms of synaptic pathology in AD and to develop potential neuroprotective agents that will operate by enhancing the GT activity. ..
  11. Mechanisms of Neuroprotection in HIV Encephalitis
    Eliezer Masliah; Fiscal Year: 2009
    ..Together these studies will help to elucidate the role of the CDK5 pathway in neurodegeneration in patients with HIVE and help at developing new neuroprotective treatments. ..
  12. SUBCELLULAR BASIS OF SYNAPTIC PATHOLOGY ALZHEIMER DIS
    Eliezer Masliah; Fiscal Year: 1993
    ..We expect that this lesion and neurotoxin combination will reproduce, in the rodent model, the widespread dystrophic alterations observed in AD and provide information about the pathogenesis of the synaptic alterations observed in AD...
  13. Alpha-synuclein clearance strategies for the treatment of Lewy body disease.
    Eliezer Masliah; Fiscal Year: 2007
    ..Thus, enhancing autophagy and lysosomal degradation of a-syn may represent a promising therapeutic strategy for the treatment not only for LBD but also for Alzheimer's disease. ..
  14. B-Synuclein as a Treatment for Lewy Body Disease
    Eliezer Masliah; Fiscal Year: 2001
    ..abstract_text> ..
  15. MECHANISMS OF FGF1 NEUROPROTECTION IN HIV ENCEPHALITIS
    Eliezer Masliah; Fiscal Year: 2005
    ..Clarification of the mechanisms by which FGF1 protects neurons against HIV will provide a potential target for the development of new treatment directed at ameliorating the neuronal damage to in AIDS patients with cognitive impairment. ..
  16. SUBCELLULAR BASIS OF SYNAPTIC PATHOLOGY ALZHEIMER DIS
    Eliezer Masliah; Fiscal Year: 1992
    ..We expect that this lesion and neurotoxin combination will reproduce, in the rodent model, the widespread dystrophic alterations observed in AD and provide information about the pathogenesis of the synaptic alterations observed in AD...
  17. BASIS OF SYNAPTIC PATHOLOGY IN ALZHEIMERS DISEASE
    Eliezer Masliah; Fiscal Year: 2000
    ..These studies will help to better understand the mechanisms of synaptic pathology in AD and to develop potential neuroprotective agents that will operate by enhancing the GT activity. ..
  18. MECHANISMS OF FGF1 NEUROPROTECTION IN HIV ENCEPHALITIS
    Eliezer Masliah; Fiscal Year: 2003
    ..Clarification of the mechanisms by which FGF1 protects neurons against HIV will provide a potential target for the development of new treatment directed at ameliorating the neuronal damage to in AIDS patients with cognitive impairment. ..
  19. B-Synuclein as a Treatment for Lewy Body Disease
    Eliezer Masliah; Fiscal Year: 2002
    ..abstract_text> ..
  20. Mechanisms of Neuroprotection in HIV Encephalitis
    Eliezer Masliah; Fiscal Year: 2010
    ..Together these studies will help to elucidate the role of the CDK5 pathway in neurodegeneration in patients with HIVE and help at developing new neuroprotective treatments. ..