Research Topics
Genomes and Genes
| Eliezer MasliahSummaryAffiliation: University of California Country: USA Publications
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Publications
Prion infection promotes extensive accumulation of α-synuclein in aged human α-synuclein transgenic miceEliezer Masliah
Department of Neuroscience, University of California, San Diego, La Jolla, CA, USA
Prion 6:184-90. 2012..Taken together, these studies support the notion that PrP(Sc) directly or indirectly promotes α-synuclein pathology...- Analysis of striatal transcriptome in mice overexpressing human wild-type alpha-synuclein supports synaptic dysfunction and suggests mechanisms of neuroprotection for striatal neuronsYofre Cabeza-Arvelaiz
Department of Pathology and Environmental Health Sciences, The Geffen School of Medicine and School of Public Health, University of California, Los Angeles, 650 Charles E, Young Dr S, CHS 71 295, Los Angeles, CA 90095, USA
Mol Neurodegener 6:83. 2011..Therefore it is of interest to understand how overexpression of SNCA affects neuronal function in regions not directly targeted for neurodegeneration in PD... - Neuromelanin, neurotransmitter status and brainstem location determine the differential vulnerability of catecholaminergic neurons to mitochondrial DNA deletionsMatthias Elstner
Department of Neurology with Friedrich Baur Institute, Ludwig Maximilians University, 81377 Munich, Germany
Mol Brain 4:43. 2011.... 
The pharmacology of neurotrophic treatment with Cerebrolysin: brain protection and repair to counteract pathologies of acute and chronic neurological disordersE Masliah
Department of Neurosciences, University of California, La Jolla, CA, USA
Drugs Today (Barc) 48:3-24. 2012..This section summarizes the most relevant data on the pharmacology of Cerebrolysin obtained from in vitro assays (biochemical and cell cultures) and in vivo animal models of acute and chronic neurological disorders...- Role of synucleins in Alzheimer's diseaseLeslie Crews
Department of Neurosciences, University of California San Diego, La Jolla, CA 92093 0624, USA
Neurotox Res 16:306-17. 2009..Thus, better understanding the steps involved in the process of Abeta and alpha-syn aggregation is important in order to develop intervention strategies that might prevent or reverse the accumulation of toxic proteins in AD... - Oxidation of the cysteine-rich regions of parkin perturbs its E3 ligase activity and contributes to protein aggregationFanjun Meng
Department of Pathology and Anatomical Sciences, Center for Translational Neuroscience, University of Missouri Columbia School of Medicine, Columbia, MO, USA
Mol Neurodegener 6:34. 2011..abstract:.. - NO signaling and S-nitrosylation regulate PTEN inhibition in neurodegenerationYoung Don Kwak
Department of Pharmacology, University of Tennessee Health Science Center, College of Medicine, 874 Union Avenue, Memphis TN, 38163, USA
Mol Neurodegener 5:49. 2010..However the molecular signals and mechanism underlying PTEN loss are unknown... - The biochemical aftermath of anti-amyloid immunotherapyChera L Maarouf
The Longtine Center for Neurodegenerative Biochemistry, Banner Sun Health Research Institute, Sun City, AZ, USA
Mol Neurodegener 5:39. 2010..These patients were compared to 6 non-immunized AD cases and 5 non-demented control (NDC) cases... - APP transgenic modeling of Alzheimer's disease: mechanisms of neurodegeneration and aberrant neurogenesisLeslie Crews
Department of Pathology, University of California, San Diego, La Jolla, CA, USA
Brain Struct Funct 214:111-26. 2010..Promising results have been obtained utilizing APP tg models of AD to develop therapies including the use of beta- and gamma-secretase inhibitors, immunization, and stimulating neurogenesis... - Region-specific tauopathy and synucleinopathy in brain of the alpha-synuclein overexpressing mouse model of Parkinson's diseaseTiffany Kaul
Department of Biochemistry and Molecular and Cell Biology, University of California San Diego, La Jolla, California, USA
BMC Neurosci 12:79. 2011..The current studies were undertaken to analyze the distribution of tauopathy in different brain regions in a widely used mouse model of PD, the α-Syn overexpressing mouse... - A prospective longitudinal in vivo 1H MR spectroscopy study of the SIV/macaque model of neuroAIDSRobert A Fuller
Massachusetts General Hospital NMR Center and Neuroradiology Division, Harvard Medical School, Charlestown, MA, USA
BMC Neurosci 5:10. 2004..Our goal was to undertsand the dynamics of cerebral injury by performing a longitudinal in vivo 1H MRS study of the SIV/macaque model of neuroAIDS... - Signalling crosstalk in FGF2-mediated protection of endothelial cells from HIV-gp120Dianne Langford
Department of Pathology, University of California, San Diego, La Jolla, CA, USA
BMC Neurosci 6:8. 2005..We hypothesized that treatment of human umbilical vein endothelial cells (HUVEC) with FGF2 would protect the cells from gp120-mediated toxicity via endothelial cell survival signalling... 
Altered expression of synaptic proteins occurs early during progression of Alzheimer's diseaseE Masliah
Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, CA, USA
Neurology 56:127-9. 2001..Levels of synaptotagmin and GAP43 were unchanged in mild AD, but cases with CDR of >1 had a progressive decrement in these synaptic proteins. Thus, synaptic injury in frontal cortex is an early event in AD...- beta-amyloid peptides enhance alpha-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's diseaseE Masliah
Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA
Proc Natl Acad Sci U S A 98:12245-50. 2001..Therefore, treatments that block the production or accumulation of beta-amyloid peptides could benefit a broader spectrum of disorders than previously anticipated... - Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disordersE Masliah
Department of Neurosciences, Department of Pathology, University of California San Diego, La Jolla, CA 92093 0624, USA
Science 287:1265-9. 2000..These results suggest that accumulation of wild-type alpha-synuclein may play a causal role in Parkinson's disease and related conditions... - Synaptic remodeling during aging and in Alzheimer's diseaseEliezer Masliah
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
J Alzheimers Dis 9:91-9. 2006..In this context, the main objective of this manuscript is to discuss the findings of our 1993 study in light of more recent studies in aging, synapses and Alzheimer's disease... - The role of synaptic proteins in Alzheimer's diseaseE Masliah
School of Medicine, Departments of Neurosciences and Pathology, University of California, San Diego, La Jolla, California 92093 0624, USA
Ann N Y Acad Sci 924:68-75. 2000.... - Phosphorylation of collapsin response mediator protein-2 disrupts neuronal maturation in a model of adult neurogenesis: Implications for neurodegenerative disordersLeslie Crews
Department of Neurosciences University of California, San Diego 9500 Gilman Drive, La Jolla, CA 92093 0624, USA
Mol Neurodegener 6:67. 2011..abstract:.. - Functional role of TGF beta in Alzheimer's disease microvascular injury: lessons from transgenic miceE Masliah
Department of Neurosciences, University of California San Diego, La Jolla, CA 92093 0624, USA
Neurochem Int 39:393-400. 2001..In this regard, further elucidation of the signal pathways by which TGF-beta exerts its effect in AD might lead to specific targets for further therapeutic intervention... - Patterns of gene dysregulation in the frontal cortex of patients with HIV encephalitisEliezer Masliah
Department of Pathology, University of California San Diego, La Jolla, CA 92093 6232, USA
J Neuroimmunol 157:163-75. 2004.... - Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer diseaseE Masliah
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA
Neurology 64:129-31. 2005..This case illustrates the effects of an Abeta-based immunization on AD pathogenesis in the absence of overt meningoencephalitis and leukoencephalopathy... - Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body diseaseEliezer Masliah
Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America
PLoS ONE 6:e19338. 2011..These results suggest that passive immunization with monoclonal antibodies against the CT of α-syn may be of therapeutic relevance in patients with PD and DLB... - Recent advances in the development of immunotherapies for tauopathiesKiren Ubhi
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
Exp Neurol 230:157-61. 2011..This commentary will discuss the use of immunotherapy for AD, focusing on tau immunotherapy in the context of recent reports on the use of tau phospho-peptides in transgenic models of tau pathology... - Effects of alpha-synuclein immunization in a mouse model of Parkinson's diseaseEliezer Masliah
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
Neuron 46:857-68. 2005..These results suggest that vaccination is effective in reducing neuronal accumulation of halpha-syn aggregates and that further development of this approach might have a potential role in the treatment of LBD... - Development of new treatments for Parkinson's disease in transgenic animal models: a role for beta-synucleinEliezer Masliah
Neurotoxicology 23:461-8. 2002..Such an anti-amyloidogenic property of beta-synuclein might also provide a novel strategy for the treatment of neurodegenerative disorders... - Long-term neprilysin gene transfer is associated with reduced levels of intracellular Abeta and behavioral improvement in APP transgenic miceBrian Spencer
Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA
BMC Neurosci 9:109. 2008..However the effects of long-term neprilysin gene transfer on other aspects of Abeta associated pathology have not been explored yet in APP transgenic mice... - Neurofibrillary and neurodegenerative pathology in APP-transgenic mice injected with AAV2-mutant TAU: neuroprotective effects of CerebrolysinKiren Ubhi
Department of Neurosciences, School of Medicine, University of California, La Jolla, San Diego, CA 92093 0624, USA
Acta Neuropathol 117:699-712. 2009..This study supports the concept that the neuroprotective effects of CBL may involve the reduction of TAU phosphorylation by regulating kinase activity... - Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteinsEmiley Pham
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA
FEBS J 277:3051-67. 2010..In conclusion, this study suggests that the presence of a subpopulation of amyloid-beta oligomers in the brains of patients with Alzheimer's disease might be related to alterations in selected synaptic proteins and cognitive impairment... - Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseasesIgor F Tsigelny
Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America
PLoS ONE 3:e3135. 2008..However the molecular characteristics and consequences of these interactions are not completely clear... - Erythropoietin plus insulin-like growth factor-I protects against neuronal damage in a murine model of human immunodeficiency virus-associated neurocognitive disordersYeon Joo Kang
Del E Webb Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, CA, USA
Ann Neurol 68:342-52. 2010..Here, we report that chronic treatment with erythropoietin (EPO) and insulin-like growth factor-I (IGF-I) protects against HIV/gp120-mediated neuronal damage in culture and in vivo... - Cerebrolysin decreases amyloid-beta production by regulating amyloid protein precursor maturation in a transgenic model of Alzheimer's diseaseEdward Rockenstein
Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, California 92093-0624, USA
J Neurosci Res 83:1252-61. 2006..This study clarifies the mechanisms through which Cerebrolysin might reduce Abeta production and deposition in AD and further supports the importance of this compound in the potential treatment of early AD... - Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer's disease are associated with reduced amyloid precursor protein phosphorylationEdward Rockenstein
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
J Neurosci 27:1981-91. 2007.... - Longer term improvement in neurocognitive functioning and affective distress among methamphetamine users who achieve stable abstinenceJennifer E Iudicello
Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, CA 92103, USA
J Clin Exp Neuropsychol 32:704-18. 2010..These results suggest partial recovery of neuropsychological functioning and improvement in affective distress upon sustained abstinence from MA that may extend beyond a year or more... - Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's diseaseJohn B Rose
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
J Neurosci 29:1115-25. 2009..This function of NEP represents a unique example of a proteolytic enzyme with dual action, namely, degradation of Abeta as well as processing of NPY... - Neurocognitive consequences of HIV infection in older adults: an evaluation of the "cortical" hypothesisJ Cobb Scott
HIV Neurobehavioral Research Center, Department of Psychiatry, University of California San Diego, San Diego, CA, USA
AIDS Behav 15:1187-96. 2011..Thus, in this sample of older HIV-infected individuals, the combined effects of HIV and aging do not appear to result in a "cortical" pattern of cognitive deficits... - Selective molecular alterations in the autophagy pathway in patients with Lewy body disease and in models of alpha-synucleinopathyLeslie Crews
Department of Pathology, University of California San Diego, La Jolla, California, United States of America
PLoS ONE 5:e9313. 2010..For this reason, we sought to examine the expression levels of members of the autophagy pathway in brains of patients with DLB and Alzheimer's Disease (AD) and in alpha-synuclein transgenic mice... - High beta-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-beta levels: implications for the treatment of Alzheimer diseaseEdward Rockenstein
Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, California 92093 0624, USA
J Biol Chem 280:32957-67. 2005..Thus, inhibiting BACE1 may block not only Abeta-dependent but also Abeta-independent pathogenic mechanisms... - Effects of Cerebrolysin on neurogenesis in an APP transgenic model of Alzheimer's diseaseEdward Rockenstein
Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, CA, 92093 0624, USA
Acta Neuropathol 113:265-75. 2007..The improved neurogenesis in the hippocampus of CBL-treated APP tg mice might play an important role in enhancing synaptic formation and memory acquisition... - Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseasesBrian Spencer
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
J Neurosci 29:13578-88. 2009..Thus, beclin 1 plays an important role in the intracellular degradation of alpha-syn either directly or indirectly through the autophagy pathway and may present a novel therapeutic target for LBD/PD... - Neurotoxic effects of the HCV core protein are mediated by sustained activation of ERK via TLR2 signalingAmy D Paulino
Department of Neurosciences, University of California San Diego, La Jolla, CA 92093 0624, USA
J Neurovirol 17:327-40. 2011..These pathways provide novel targets for development of neuroprotective treatments for HCV involvement of the CNS... - Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic modelOded Singer
Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Neurosci 8:1343-9. 2005.... - Altered p59Fyn kinase expression accompanies disease progression in Alzheimer's disease: implications for its functional roleGilbert J Ho
Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0624, USA
Neurobiol Aging 26:625-35. 2005..Taken together, these findings suggest that alterations in Fyn localization might be associated with neurofibrillary pathology and synapse loss in AD... - Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathiesAndrew O Koob
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA
Exp Neurol 221:267-74. 2010.... - Increased frequency of alpha-synuclein in the substantia nigra in human immunodeficiency virus infectionNegar Khanlou
Department of Pathology and Laboratory Medicine, Division of Neuropathology, David Geffen School of Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, California, USA
J Neurovirol 15:131-8. 2009..The increased prevalence of alpha-synuclein and beta-amyloid in the brains of older HIV-infected individuals may predict an increased risk of developing neurodegenerative disease... - Neprilysin regulates amyloid Beta peptide levelsRobert A Marr
Laboratory of Genetics, Salk Institute, La Jolla, CA 92037, USA
J Mol Neurosci 22:5-11. 2004..These studies provide the impetus for further investigating of the use of NEP in a gene transfer therapy paradigm to prevent the accumulation of Abeta and prevent or delay the onset of Alzheimer's disease... - Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1Anna E Cartier
Section of Neurobiology, Department of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0347, USA
J Neurosci 29:7857-68. 2009..These findings point to a significant role of UCH-L1 in synaptic remodeling, most likely by modulating free monomeric ubiquitin levels in an activity-dependent manner... - Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophyClifford W Shults
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
J Neurosci 25:10689-99. 2005..Together, these studies support the contention that accumulation of alpha-syn in oligodendrocytes promotes neurodegeneration and recapitulates several of the key functional and neuropathological features of MSA... - Increased accumulation of intraneuronal amyloid beta in HIV-infected patientsCristian L Achim
Department of Psychiatry, University of California, San Diego, CA 92093 0624, USA
J Neuroimmune Pharmacol 4:190-9. 2009..These findings suggest that long-term survival with HIV might interfere with clearance of proteins such as Abeta and worsen neuronal damage and cognitive impairment in this population... - Methamphetamine use parameters do not predict neuropsychological impairment in currently abstinent dependent adultsMariana Cherner
Department of Psychiatry, University of California San Diego School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093 0847, USA
Drug Alcohol Depend 106:154-63. 2010..The apparent lack of correspondence between substance use parameters and cognitive impairment suggests the need for further study of individual differences in vulnerability to the neurotoxic effects of methamphetamine... - Type 1 diabetes exaggerates features of Alzheimer's disease in APP transgenic miceCorinne G Jolivalt
Department of Pathology, University of California San Diego, La Jolla, CA 92093 0612, USA
Exp Neurol 223:422-31. 2010.... - The semantic relatedness of cue-intention pairings influences event-based prospective memory failures in older adults with HIV infectionSteven Paul Woods
HIV Neurobehavioral Research Center, Department of Psychiatry, University of California, San Diego, CA 92103, USA
J Clin Exp Neuropsychol 32:398-407. 2010.... - Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic miceJeannie Chin
Gladstone Institute of Neurological Disease and Department of Neurology, University of California, San Francisco, California 94141 9100, USA
J Neurosci 24:4692-7. 2004..We conclude that Fyn-dependent pathways are critical in AD-related synaptotoxicity and that the pathogenesis of hAPP/Abeta-induced neuronal alterations may be mechanistically heterogenous... - Beneficial effects of a neurotrophic peptidergic mixture persist for a prolonged period following treatment interruption in a transgenic model of Alzheimer's diseaseEdward Rockenstein
Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, California 92093 0624, USA
J Neurosci Res 89:1812-21. 2011.... - Neurobehavioral effects of human immunodeficiency virus infection among former plasma donors in rural ChinaRobert K Heaton
HIV Neurobehavioral Research Center HNRC, Department of Psychiatry, University of California at San Diego, San Diego, California 92093 0603, USA
J Neurovirol 14:536-49. 2008..These findings indicate that HAND is likely to be an important feature of HIV infection in developing countries, underscoring the need for international efforts to develop CNS-relevant treatments... - Neurodegeneration in a transgenic mouse model of multiple system atrophy is associated with altered expression of oligodendroglial-derived neurotrophic factorsKiren Ubhi
Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, California 92093 0624, USA
J Neurosci 30:6236-46. 2010..These results suggest a mechanism in which alphasyn expression in oligodendrocytes impacts on the trophic support provided by these cells for neurons, perhaps contributing to neurodegeneration... - Glycogen synthase kinase-3beta (GSK-3beta) inhibitors AR-A014418 and B6B3O prevent human immunodeficiency virus-mediated neurotoxicity in primary human neuronsTimothy B Nguyen
Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, California 92093 0603, USA
J Neurovirol 15:434-8. 2009..These data support a role for GSK3beta as a potential therapeutic target and may have important clinical implications for treatment of HIV-associated neurocognitive disorder... - Intraindividual variability in HIV infection: evidence for greater neurocognitive dispersion in older HIV seropositive adultsErin E Morgan
Department of Psychiatry, University of California, San Diego, CA 92103, USA
Neuropsychology 25:645-54. 2011..To our knowledge, no studies have yet examined dispersion in an aging HIV-infected sample... - Alpha-synuclein alters Notch-1 expression and neurogenesis in mouse embryonic stem cells and in the hippocampus of transgenic miceLeslie Crews
Departments of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
J Neurosci 28:4250-60. 2008..Together, these results suggest that accumulation of alpha-syn might impair survival of NPCs by interfering with the Notch signaling pathway. Similar mechanisms could be at play in PD and Lewy body disease... - Is prospective memory a dissociable cognitive function in HIV infection?Saurabh Gupta
Department of Psychiatry, University of California, San Diego, CA 92103, USA
J Clin Exp Neuropsychol 32:898-908. 2010..The results of this study lend further evidence to the dissociability of ProM in HIV infection, are consistent with prior studies in healthy adults, and contribute to a growing literature on the construct validity of ProM in HIV disease... - Mutant Pink1 induces mitochondrial dysfunction in a neuronal cell model of Parkinson's disease by disturbing calcium fluxRoberta Marongiu
Department of Neurosciences, University of California, San Diego, La Jolla, California, USA
J Neurochem 108:1561-74. 2009..Moreover, these studies support an important function for Pink1 in regulating mitochondrial activity under stress conditions... - Peripheral delivery of a CNS targeted, metalo-protease reduces aβ toxicity in a mouse model of Alzheimer's diseaseBrian Spencer
Department of Neurosciences, University of California San Diego, La Jolla, California, United States of America
PLoS ONE 6:e16575. 2011..Thus, the addition of the ApoB transport domain to the secreted neprilysin generated a non-invasive therapeutic approach that may be a potential treatment in patients with AD... - A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegenerationDavid A Scott
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
J Neurosci 30:8083-95. 2010..Collectively the data suggest a previously unknown cascade of events where pathologic alpha-synuclein leads to a loss of a number of critical presynaptic proteins, thereby inducing functional synaptic deficits... - The role of mitochondrial alterations in the combined toxic effects of human immunodeficiency virus Tat protein and methamphetamine on calbindin positive-neuronsDianne Langford
Department of Pathology, University of California, San Diego, La Jolla, California 92093-0624, USA
J Neurovirol 10:327-37. 2004..In combination, Tat and METH may increase cell injury and death, thereby enhancing brain metabolic disturbances observed in HIV-positive METH users in clinical populations... - Spontaneous strategy use protects against visual working memory deficits in older adults infected with HIVSteven Paul Woods
Department of Psychiatry, University of California San Diego, La Jolla, USA
Arch Clin Neuropsychol 25:724-33. 2010.... - alpha-Synuclein aggregates interfere with Parkin solubility and distribution: role in the pathogenesis of Parkinson diseaseKohichi Kawahara
Department of Neurosciences, School of Medicine, University of California at San Diego, La Jolla, California 92039 0624, USA
J Biol Chem 283:6979-87. 2008..These studies provide a new perspective on the potential nature of pathogenic alpha-synuclein and parkin interactions in Parkinson disease... - Neprilysin gene transfer reduces human amyloid pathology in transgenic miceRobert A Marr
Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Neurosci 23:1992-6. 2003..These data further support a role for neprilysin in regulating cerebral amyloid deposition and suggest that gene transfer approaches might have potential for the development of alternative therapies for Alzheimer's disease... - Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrusBeate Winner
Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
J Neurosci 32:16906-16. 2012..The current work provides novel insights into the role of α-synuclein in adult hippocampal neurogenesis... - Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated proteinEmily Van Uden
Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, California 92093 0624, USA
J Neurosci 22:9298-304. 2002..Together, these results further support the contention that LRP and other lipoprotein receptors might be neuroprotective against Abeta toxicity and that this receptor might play an integral role in Abeta clearance... - Regional comparison of the neurogenic effects of CNTF-derived peptides and cerebrolysin in AβPP transgenic miceEdward Rockenstein
University of California, San Diego, Neurosciences Department, La Jolla, CA 92093 0624, USA
J Alzheimers Dis 27:743-52. 2011..These results are consistent with a potential therapeutic relevance for Peptides 6 and 6A in AD and other disorders characterized by neurogenic deficits... - Neuropathology of dementia with Lewy bodies in advanced age: a comparison with Alzheimer diseaseKiren Ubhi
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA
Neurosci Lett 485:222-7. 2010..Taken together these results suggest that the oldest old with DLB might represent a distinct group... - Correlation of major depressive disorder symptoms with FKBP5 but not FKBP4 expression in human immunodeficiency virus-infected individualsErick T Tatro
Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0603, USA
J Neurovirol 16:399-404. 2010..Change in FKBP4 expression did not correlate with changes in clinical or depression measurements. Higher FKBP5 expression correlated with greater symptom change for GG carriers of rs3800373... - Cytochrome P450-2D6 extensive metabolizers are more vulnerable to methamphetamine-associated neurocognitive impairment: preliminary findingsMariana Cherner
Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0847, USA
J Int Neuropsychol Soc 16:890-901. 2010..This preliminary study is the first to suggest that efficient meth metabolism is associated with worse neurocognitive outcomes in humans, and implicates the products of oxidative metabolism of meth as a possible source of brain injury... - Prospective memory deficits are associated with unemployment in persons living with HIV infectionSteven Paul Woods
Department of Psychiatry, University of California, San Diego, USA
Rehabil Psychol 56:77-84. 2011..To determine whether deficits in prospective memory (i.e., "remembering to remember") confer an increased risk of unemployment in individuals living with chronic HIV infection... - Demographically corrected norms for African Americans and Caucasians on the Hopkins Verbal Learning Test-Revised, Brief Visuospatial Memory Test-Revised, Stroop Color and Word Test, and Wisconsin Card Sorting Test 64-Card VersionMarc A Norman
Department of Psychiatry, University of California, San Diego, CA, USA
J Clin Exp Neuropsychol 33:793-804. 2011..Findings support the need to consider extended demographic contributions to neuropsychological test performance in clinical and research settings... - HIV-associated prospective memory impairment in the laboratory predicts failures on a semi-naturalistic measure of health care complianceJennifer B Zogg
Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
Clin Neuropsychol 24:945-62. 2010..g., depression). Results support the hypothesis that ProM plays a unique role in compliance with health care instructions for HIV disease management and may inform interventions designed to improve treatment outcomes... - Misremembering future intentions in methamphetamine-dependent individualsJennifer E Iudicello
Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California, San Diego, CA, USA
Clin Neuropsychol 25:269-86. 2011..Findings suggest that individuals with MA dependence experience difficulty in the strategic components involved in the retrieval of future intentions and are discussed with regard to their implications for everyday functioning... - Visuospatial deficits predict rate of cognitive decline in autopsy-verified dementia with Lewy bodiesJoanne M Hamilton
Department of Neurosciences, University of California, USA
Neuropsychology 22:729-37. 2008.... - Alpha-synuclein up-regulates expression of caveolin-1 and down-regulates extracellular signal-regulated kinase activity in B103 neuroblastoma cells: role in the pathogenesis of Parkinson's diseaseMakoto Hashimoto
Department of Neuroscience, University of California at San Diego, La Jolla, California 92093 0624, USA
J Neurochem 85:1468-79. 2003..Thus, the caveolin-1/ERK pathway could be a therapeutic target for the alpha-synuclein-related neurodegenerative disorders... - Cortical and subcortical neurodegeneration is associated with HIV neurocognitive impairmentDavid J Moore
HIV Neurobehavioral Research Center and University of California, San Diego, California 92161, USA
AIDS 20:879-87. 2006..To determine the association of markers of regional neurodegeneration (ND) at autopsy to degree of neurocognitive impairment in persons with HIV... - Patterns of selective neuronal damage in methamphetamine-user AIDS patientsDianne Langford
Department of Pathology, University of California at San Francisco, La Jolla, CA 92093-0624, USA
J Acquir Immune Defic Syndr 34:467-74. 2003..In combination, METH and HIV may increase neuronal cell injury and death, thereby enhancing brain metabolic disturbances observed in clinical populations of HIV-positive METH abusers... - Abeta1-42 promotes cholinergic sprouting in patients with AD and Lewy body variant of ADE Masliah
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093 0624, USA emasliah ucsd edu
Neurology 61:206-11. 2003.... - Transgenic models to assess the pathogenic actions of cytokines in the central nervous systemI L Campbell
Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037, USA
Mol Psychiatry 2:125-9. 1997..Thus, expression of specific cytokines alone in the intact CNS results in unique neuropathological alterations and functional impairments, thereby directly implicating these mediators in the pathogenesis of CNS disease... - Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promotersEdward Rockenstein
Department of Neurosciences, University of California San Diego, La Jolla, California 92093-0624, USA
J Neurosci Res 68:568-78. 2002.... - Age at onset is associated with disease severity in Lewy body variant and Alzheimer's diseaseGilbert J Ho
Department of Neuroscience, University of California, San Diego, La Jolla, CA 92093-0624, USA
Neuroreport 13:1825-8. 2002..Taken together, these results suggest that for both LBV and AD, earlier age at onset may predict a more aggressive disease course... - Transgenic animal models of neurodegenerative diseases and their application to treatment developmentEdward Rockenstein
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
Adv Drug Deliv Rev 59:1093-102. 2007.... - Fibroblast growth factor 1 regulates signaling via the glycogen synthase kinase-3beta pathway. Implications for neuroprotectionMakoto Hashimoto
Department of Neurosciences, University of California San Diego, La Jolla, California 92093 0624, USA
J Biol Chem 277:32985-91. 2002..Taken together these results suggest that neuroprotective effects of FGF1 might involve inactivation of GSK3beta by a pathway involving activation of the PI3K-Akt cascades... - Severe, demyelinating leukoencephalopathy in AIDS patients on antiretroviral therapyT Dianne Langford
Department of Pathology, University of California, San Diego, CA, USA
AIDS 16:1019-29. 2002..This condition warrants further study and increased vigilance among those who provide care for HIV-infected individuals... - Axonopathy and transport deficits early in the pathogenesis of Alzheimer's diseaseGorazd B Stokin
Howard Hughes Medical Institute and Department of Cellular and Molecular Medicine, School of Medicine, University of California San Diego UCSD, 9500 Gilman Drive, La Jolla, CA 92093, USA
Science 307:1282-8. 2005..Reductions in microtubule-dependent transport may stimulate proteolytic processing of beta-amyloid precursor protein, resulting in the development of senile plaques and Alzheimer's disease... - Neurofibrillary pathology in transgenic mice overexpressing V717F beta-amyloid precursor proteinE Masliah
Department of Neurosciences, University of California San Diego, La Jolla 92093-0624, USA
J Neuropathol Exp Neurol 60:357-68. 2001..However, no paired helical filaments were observed. Taken together, these studies indicate that the PDAPP tg model recapitulates early cytoskeletal pathology similar to that observed in AD... - High-level neuronal expression of abeta 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formationL Mucke
Gladstone Institute of Neurological Disease, Department of Neurology, and Neuroscience Program, University of California, San Francisco, California 94141 9100, USA
J Neurosci 20:4050-8. 2000..Our results support the emerging view that plaque-independent Abeta toxicity plays an important role in the development of synaptic deficits in AD and related conditions... - Transgenic expression of IFN-alpha in the central nervous system of mice protects against lethal neurotropic viral infection but induces inflammation and neurodegenerationY Akwa
Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037, USA
J Immunol 161:5016-26. 1998..These transgenic mice provide a novel animal model in which to further evaluate the mechanisms that underlie the diverse actions of type I IFNs in the intact CNS... - Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formationManuel Buttini
Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94141 9100, USA
J Neurosci 22:10539-48. 2002..Thus, apoE3, but not apoE4, delays age- and Abeta-dependent synaptic deficits through a plaque-independent mechanism. This difference could contribute to the differential effects of apoE isoforms on the risk and onset of AD... - Rifampicin reduces alpha-synuclein in a transgenic mouse model of multiple system atrophyKiren Ubhi
Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, California, USA
Neuroreport 19:1271-6. 2008..This reduction in alpha-synuclein aggregation was accompanied by reduced neurodegeneration. On the basis of its anti-aggregenic properties, we conclude that rifampicin may have therapeutic potential for MSA... - Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's miceTony Wyss-Coray
Gladstone Institute of Neurological Disease, University of California, San Francisco, CA 94141, USA
Proc Natl Acad Sci U S A 99:10837-42. 2002.... - The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in miceFiona Pickford
Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA
J Clin Invest 118:2190-9. 2008..We conclude that beclin 1 deficiency disrupts neuronal autophagy, modulates APP metabolism, and promotes neurodegeneration in mice and that increasing beclin 1 levels may have therapeutic potential in AD... - Effects of the cholesterol-lowering compound methyl-beta-cyclodextrin in models of alpha-synucleinopathyPazit Bar-On
Department of Neurosciences, University of California, San Diego, La Jolla, 92093-0624, USA
J Neurochem 98:1032-45. 2006..Taken together, these results suggest that changes in cholesterol and lipid composition using cholesterol-lowering agents may be used as a tool for the treatment of synucleinopathies... - beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factorM Hashimoto
Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
Neuron 32:213-23. 2001..Such an anti-amyloidogenic property of beta-synuclein might also provide a novel strategy for the treatment of neurodegenerative disorders... - The neuroprotective effects of Cerebrolysin in a transgenic model of Alzheimer's disease are associated with improved behavioral performanceE Rockenstein
Department of Neurosciences, University of California San Diego, School of Medicine, La Jolla, CA 92093, USA
J Neural Transm 110:1313-27. 2003..Taken together, these results suggest that Cerebrolysin treatment might have beneficial effects in patients with cognitive impairment by reducing A beta accumulation and promoting the preservation of synaptic terminals... - Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's diseaseJeannie Chin
Gladstone Institute of Neurological Disease, University of California, San Francisco, California 94158, USA
J Neurosci 25:9694-703. 2005..Thus, increased Fyn expression is sufficient to trigger prominent neuronal deficits in the context of even relatively moderate Abeta levels, and inhibition of Fyn activity may help counteract Abeta-induced impairments... - Neurobiology of HIVBritta Hult
Department of Psychiatry, University of California, San Diego, CA, USA
Int Rev Psychiatry 20:3-13. 2008..Given the variable success of the current HAART drugs against virus in the CNS, such therapies would greatly benefit the HIV infected population as they live longer and more productive lives... - Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorderErick T Tatro
Department of Psychiatry 0603, University of California at San Diego, La Jolla, San Diego, CA 92093 0603, USA
J Neuroimmune Pharmacol 4:218-26. 2009..Instead, an increase in FKBP51 at both the transcript (FKBP5) and protein level correlated with MDD. Increased FKBP4 expression of correlated to HIV(+)MDD but not to HIV without MDD...
Research Grants
- B-Synuclein as a Treatment for Lewy Body DiseaseEliezer Masliah; Fiscal Year: 2005..abstract_text> ..
- MECHANISMS OF FGF1 NEUROPROTECTION IN HIV ENCEPHALITISEliezer Masliah; Fiscal Year: 2006..Clarification of the mechanisms by which FGF1 protects neurons against HIV will provide a potential target for the development of new treatment directed at ameliorating the neuronal damage to in AIDS patients with cognitive impairment. ..
- Alpha-synuclein clearance strategies for the treatment of Lewy body disease.Eliezer Masliah; Fiscal Year: 2007..Thus, enhancing autophagy and lysosomal degradation of a-syn may represent a promising therapeutic strategy for the treatment not only for LBD but also for Alzheimer's disease. ..
- Mechanisms of Neuroprotection in HIV EncephalitisEliezer Masliah; Fiscal Year: 2007..Together these studies will help to elucidate the role of the CDK5 pathway in neurodegeneration in patients with HIVE and help at developing new neuroprotective treatments. ..
- Mechanisms of Neuroprotection in HIV EncephalitisEliezer Masliah; Fiscal Year: 2009..Together these studies will help to elucidate the role of the CDK5 pathway in neurodegeneration in patients with HIVE and help at developing new neuroprotective treatments. ..
- SUBCELLULAR BASIS OF SYNAPTIC PATHOLOGY ALZHEIMER DISEliezer Masliah; Fiscal Year: 1993..We expect that this lesion and neurotoxin combination will reproduce, in the rodent model, the widespread dystrophic alterations observed in AD and provide information about the pathogenesis of the synaptic alterations observed in AD...
- BASIS OF SYNAPTIC PATHOLOGY IN ALZHEIMERS DISEASEEliezer Masliah; Fiscal Year: 2001..These studies will help to better understand the mechanisms of synaptic pathology in AD and to develop potential neuroprotective agents that will operate by enhancing the GT activity. ..
- Mechanisms of Neuroprotection in HIV EncephalitisEliezer Masliah; Fiscal Year: 2010..Together these studies will help to elucidate the role of the CDK5 pathway in neurodegeneration in patients with HIVE and help at developing new neuroprotective treatments. ..