Deborah Mash

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. ncbi request reprint Serotonin transporters upregulate with chronic cocaine use
    D C Mash
    Department of Neurology, School of Medicine, University of Miami, Miami, FL 33136, USA
    J Chem Neuroanat 20:271-80. 2000
  2. ncbi request reprint Norepinephrine transporter immunoblotting and radioligand binding in cocaine abusers
    Deborah C Mash
    Department of Neurology D4 5, School of Medicine, University of Miami, 1501 N W 9th Avenue, Miami, FL 33136, USA
    J Neurosci Methods 143:79-85. 2005
  3. ncbi request reprint Dopamine transport function is elevated in cocaine users
    Deborah C Mash
    Department of Neurology, University of Miami School of Medicine, FL 33101, USA
    J Neurochem 81:292-300. 2002
  4. ncbi request reprint Cocaine abusers have an overexpression of alpha-synuclein in dopamine neurons
    Deborah C Mash
    Department of Neurology, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Neurosci 23:2564-71. 2003
  5. ncbi request reprint Cocaine abuse elevates alpha-synuclein and dopamine transporter levels in the human striatum
    Yujing Qin
    Department of Neurology, University of Miami School of Medicine, Miami, FL 33101, USA
    Neuroreport 16:1489-93. 2005
  6. ncbi request reprint Markers for dopaminergic neurotransmission in the cerebellum in normal individuals and patients with Parkinson's disease examined by RT-PCR
    Michael J Hurley
    Neurology Department, University of Miami School of Medicine, Miami, FL, 33136, USA
    Eur J Neurosci 18:2668-72. 2003
  7. ncbi request reprint Cause, seasonality of death and co-morbidities in progressive supranuclear palsy (PSP)
    Spiridon Papapetropoulos
    Department of Neurology, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Parkinsonism Relat Disord 11:459-63. 2005
  8. ncbi request reprint Natural history of progressive supranuclear palsy: a clinicopathologic study from a population of brain donors
    Spiridon Papapetropoulos
    Department of Neurology, School of Medicine, University of Miami, Miami, FL 33136, USA
    Eur Neurol 54:1-9. 2005
  9. ncbi request reprint Family history of dementia: dementia with lewy bodies and dementia in Parkinson's disease
    Spiridon Papapetropoulos
    Department of Neurology, University of Miami, Miller School of Medicine, Miami FL, 33136, USA
    J Neuropsychiatry Clin Neurosci 18:113-6. 2006
  10. ncbi request reprint Insular pathology in Parkinson's disease patients with orthostatic hypotension
    Spiridon Papapetropoulos
    Department of Neurology, University of Miami, Miller School of Medicine, Room 4004, 1501 NW 9th Avenue, Miami, FL 33136, USA
    Parkinsonism Relat Disord 13:308-11. 2007

Research Grants

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Serotonin transporters upregulate with chronic cocaine use
    D C Mash
    Department of Neurology, School of Medicine, University of Miami, Miami, FL 33136, USA
    J Chem Neuroanat 20:271-80. 2000
    ..Adaptive changes in the SERT densities may contribute to depressed mood and drug craving associated with acute cocaine abstinence...
  2. ncbi request reprint Norepinephrine transporter immunoblotting and radioligand binding in cocaine abusers
    Deborah C Mash
    Department of Neurology D4 5, School of Medicine, University of Miami, 1501 N W 9th Avenue, Miami, FL 33136, USA
    J Neurosci Methods 143:79-85. 2005
    ..These results demonstrate that immunologic and radioligand binding approaches afford specific labeling of the native transport protein in postmortem human brain...
  3. ncbi request reprint Dopamine transport function is elevated in cocaine users
    Deborah C Mash
    Department of Neurology, University of Miami School of Medicine, FL 33101, USA
    J Neurochem 81:292-300. 2002
    ....
  4. ncbi request reprint Cocaine abusers have an overexpression of alpha-synuclein in dopamine neurons
    Deborah C Mash
    Department of Neurology, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Neurosci 23:2564-71. 2003
    ..However, the accumulation of alpha-synuclein protein with long-term cocaine abuse may put addicts at increased risk for developing the motor abnormalities of Parkinson's disease...
  5. ncbi request reprint Cocaine abuse elevates alpha-synuclein and dopamine transporter levels in the human striatum
    Yujing Qin
    Department of Neurology, University of Miami School of Medicine, Miami, FL 33101, USA
    Neuroreport 16:1489-93. 2005
    ..Overexpression of alpha-synuclein may play a role in cocaine-induced plasticity and regulation of dopamine synaptic tone...
  6. ncbi request reprint Markers for dopaminergic neurotransmission in the cerebellum in normal individuals and patients with Parkinson's disease examined by RT-PCR
    Michael J Hurley
    Neurology Department, University of Miami School of Medicine, Miami, FL, 33136, USA
    Eur J Neurosci 18:2668-72. 2003
    ....
  7. ncbi request reprint Cause, seasonality of death and co-morbidities in progressive supranuclear palsy (PSP)
    Spiridon Papapetropoulos
    Department of Neurology, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Parkinsonism Relat Disord 11:459-63. 2005
    ..Deaths that occurred during winter and spring months accounted for about 70% of deaths among PSP patients. The most common co-morbid condition in PSP was hypertension, present in 50% of cases...
  8. ncbi request reprint Natural history of progressive supranuclear palsy: a clinicopathologic study from a population of brain donors
    Spiridon Papapetropoulos
    Department of Neurology, School of Medicine, University of Miami, Miami, FL 33136, USA
    Eur Neurol 54:1-9. 2005
    ..Our results further demonstrate and expand the varied clinical picture of PSP. Furthermore, we report associations between older age at onset, early dementia, early falls and smoking with shorter PSP duration...
  9. ncbi request reprint Family history of dementia: dementia with lewy bodies and dementia in Parkinson's disease
    Spiridon Papapetropoulos
    Department of Neurology, University of Miami, Miller School of Medicine, Miami FL, 33136, USA
    J Neuropsychiatry Clin Neurosci 18:113-6. 2006
    ..Findings suggest that positive family history for dementia is associated with DLB with a yet unknown mechanism...
  10. ncbi request reprint Insular pathology in Parkinson's disease patients with orthostatic hypotension
    Spiridon Papapetropoulos
    Department of Neurology, University of Miami, Miller School of Medicine, Room 4004, 1501 NW 9th Avenue, Miami, FL 33136, USA
    Parkinsonism Relat Disord 13:308-11. 2007
    ..Our results suggest an association between the severity of PD-related neuropathology in the insular cortex and OH. Further research into the subject is warranted...
  11. ncbi request reprint Cortical and amygdalar Lewy body burden in Parkinson's disease patients with visual hallucinations
    Spiridon Papapetropoulos
    Department of Neurology, Miller School of Medicine, University of Miami, 1501 NW 9th Avenue NPF, Room 4004, Miami, FL 33136, USA
    Parkinsonism Relat Disord 12:253-6. 2006
    ..Although our results suggest significant extranigral involvement, the precise etiopathologic mechanisms responsible for the development of VH need further clarification...
  12. ncbi request reprint Phenotypic associations of tau and ApoE in Parkinson's disease
    Spiridon Papapetropoulos
    Department of Neurology, University of Miami, Miller School of Medicine, Miami, FL 33136, United States
    Neurosci Lett 414:141-4. 2007
    ..Better determination of subsets of PD patients based upon the presence of specific phenotypic features may improve the accuracy of association studies...
  13. doi request reprint Beyond Guam: the cyanobacteria/BMAA hypothesis of the cause of ALS and other neurodegenerative diseases
    Walter G Bradley
    Department of Neurology, Miller School of Medicine, University of Miami, 1120 NW 14 Street, Miami, FL 33136, USA
    Amyotroph Lateral Scler 10:7-20. 2009
    ....
  14. doi request reprint Brain biomarkers for identifying excited delirium as a cause of sudden death
    Deborah C Mash
    Department Neurology, Miller School of Medicine, University of Miami, 1501 NW 9th Avenue, Miami, FL 33136, USA
    Forensic Sci Int 190:e13-9. 2009
    ..When combined with descriptions of the decedents' behavior prior to death, a 2-protein biomarker signature can serve as a reliable forensic tool for identifying the excited delirium syndrome at autopsy...
  15. pmc Alpha synuclein protein levels are increased in serum from recently abstinent cocaine abusers
    Deborah C Mash
    Department of Neurology, Miller School of Medicine, Miami, FL 33136, United States
    Drug Alcohol Depend 94:246-50. 2008
    ..These data agree with previous reports in postmortem brain of cocaine abusers and provide support for an association between alpha synuclein and cocaine dependence...
  16. pmc Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling
    Deborah C Mash
    Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, United States of America
    PLoS ONE 2:e1187. 2007
    ..Extracellular matrix remodeling in the hippocampus may be a persisting effect of chronic abuse that contributes to the compulsive and relapsing nature of cocaine addiction...
  17. ncbi request reprint Multiregional gene expression profiling identifies MRPS6 as a possible candidate gene for Parkinson's disease
    Spiridon Papapetropoulos
    Department of Neurology, University of Miami, Miller School of Medicine, Miami, FL 33136, USA
    Gene Expr 13:205-15. 2006
    ..The top gene reported here is the nuclear encoded MRPS6, a building block of the human mitoribosome of the oxidative phosphorylation system (OXPHOS). Impairments in mitochondrial OXPHOS have been linked to the pathogenesis of PD...
  18. ncbi request reprint Melatonin MT1 and MT2 receptor expression in Parkinson's disease
    Nikhil Adi
    Department of Neurology, University of Miami, Miller School of Medicine, Miami, FL, USA
    Med Sci Monit 16:BR61-7. 2010
    ..Although the role of melatonin, a potent endogenous antioxidant, has been highlighted in PD there is no data on the expression of melatonin receptors in affected CNS regions...
  19. ncbi request reprint Clinical heterogeneity of the LRRK2 G2019S mutation
    Spiridon Papapetropoulos
    Department of Neurology, University of Miami School of Medicine, Miami, FL, USA
    Arch Neurol 63:1242-6. 2006
    ..The "common" LRRK2 G2019S kinase domain substitution has been reported to account for approximately 5% of familial and 1% of sporadic Parkinson disease...
  20. ncbi request reprint Expression of alpha-synuclein mRNA in Parkinson's disease
    Spiridon Papapetropoulos
    Mov Disord 22:1057-9; author reply 1057. 2007
  21. ncbi request reprint Dopaminergic innervation of the human striatum in Parkinson's disease
    Spiridon Papapetropoulos
    Mov Disord 22:286-8. 2007
  22. ncbi request reprint Locus coeruleus neurofibrillary degeneration in aging, mild cognitive impairment and early Alzheimer's disease
    Aneta Grudzien
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University, Feinberg School of Medicine, 320 East Superior Street, Searle 11 453, Chicago, IL 60611, USA
    Neurobiol Aging 28:327-35. 2007
    ..These results indicate that cytopathology in the LC is an early event in the age-MCI-AD continuum and that it may be listed among the numerous factors that mediate the emergence of the cognitive changes leading to dementia...
  23. pmc Quantitative PCR-based screening of alpha-synuclein multiplication in multiple system atrophy
    Sarah J Lincoln
    Department of Neuroscience, Molecular Genetics Laboratory and Core, Morris K Udall Parkinson s Disease Research Center of Excellence, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Parkinsonism Relat Disord 13:340-2. 2007
    ..The present study did not find any SNCA multiplications in a series of 58 pathologically confirmed MSA cases excluding this event as a common cause of MSA. The question of a genetic component in MSA remains to be answered...
  24. ncbi request reprint Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain
    Sharon Miksys
    Centre for Addiction and Mental Health, Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Neuropharmacology 45:122-32. 2003
    ..Higher brain CYP2B6 activity in smokers and alcoholics may cause altered sensitivity to centrally acting drugs, increased susceptibility to neurotoxins and carcinogenic xenobiotics and contribute to central tolerance to nicotine...
  25. ncbi request reprint Criteria for the interpretation of cocaine levels in human biological samples and their relation to the cause of death
    Boyd G Stephens
    Office of the Chief Medical Examiner, City and County of San Francisco, San Francisco, California, 94103 4603, USA
    Am J Forensic Med Pathol 25:1-10. 2004
    ..Knowledge of and an understanding of the current relevant forensic literature on this subject should be available to the reviewer prior to any interpretation of the significance of cocaine upon a specific death...
  26. ncbi request reprint Molecular profiling of midbrain dopamine regions in cocaine overdose victims
    Wen Xue Tang
    Department of Pharmacology and Psychiatry Behavioral Sciences, Yerkes National Primate Research Center, Neuroscience Division, Emory University School of Medicine, 954 Gatewood Road, Atlanta, GA 30329, USA
    J Neurochem 85:911-24. 2003
    ....
  27. ncbi request reprint Does cigarette smoking provide clinically significant neuroprotection among patients diagnosed with Parkinson's disease?
    Spiridon Papapetropoulos
    Mov Disord 20:641-2. 2005
  28. ncbi request reprint Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics
    Sharon Miksys
    Centre for Addiction and Mental Health, Department of Pharmacology, University of Toronto, Canada
    J Neurochem 82:1376-87. 2002
    ..These data suggest that in alcoholics elevated brain CYP2D6 expression may contribute to altered sensitivity to centrally acting drugs and to the mediation of neurotoxic and behavioral effects of alcohol...
  29. pmc Decreased expression of the transcription factor NURR1 in dopamine neurons of cocaine abusers
    Michael J Bannon
    Department of Psychiatry and Behavioral Neurosciences, Pharmacology, and Pathology, Wayne State University School of Medicine, 2309 Scott Hall, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Proc Natl Acad Sci U S A 99:6382-5. 2002
    ....
  30. ncbi request reprint Cocaine-induced alterations in nucleus accumbens ionotropic glutamate receptor subunits in human and non-human primates
    Scott E Hemby
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurochem 95:1785-93. 2005
    ..Furthermore, these changes may mediate persistent drug intake and craving in the human cocaine abuser...
  31. pmc Genetic variation in human NPY expression affects stress response and emotion
    Zhifeng Zhou
    Laboratory of Neurogenetics, NIAAA, NIH, Bethesda, Maryland 20892, USA
    Nature 452:997-1001. 2008
    ..These convergent findings are consistent with the function of NPY as an anxiolytic peptide and help to explain inter-individual variation in resiliency to stress, a risk factor for many diseases...
  32. ncbi request reprint Galanin receptor over-expression within the amygdala in early Alzheimer's disease: an in vitro autoradiographic analysis
    Sylvia Perez
    Department of Neurological Science, Rush Presbyterian, St Luke s Medical Center, Chicago, IL 60612, USA
    J Chem Neuroanat 24:109-16. 2002
    ..The over-expression of GALRs in subfields of the amygdaloid early in AD suggests that galaninergic systems play a key role in limbic related behavioral changes during the disease process...
  33. ncbi request reprint Visual hallucinations in progressive supranuclear palsy
    Spiridon Papapetropoulos
    Eur Neurol 54:217-9. 2005
  34. pmc A genomic pathway approach to a complex disease: axon guidance and Parkinson disease
    Timothy G Lesnick
    Division of Biostatistics, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota, United States of America
    PLoS Genet 3:e98. 2007
    ..This genomic pathway approach may also offer insights into other complex diseases such as Alzheimer disease, diabetes mellitus, nicotine and alcohol dependence, and several cancers...
  35. ncbi request reprint Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment
    Angela L Guillozet
    Cognitive Neurology and Alzheimer s Disease Center, Northwestern University, Chicago, IL 60611, USA
    Arch Neurol 60:729-36. 2003
    ..Whether a similar relationship exists in normal aging and mild cognitive impairment (MCI), a condition that frequently reflects a preclinical stage of AD, remains unknown...
  36. pmc Causes of death in multiple system atrophy
    Spiridon Papapetropoulos
    J Neurol Neurosurg Psychiatry 78:327-9. 2007
  37. ncbi request reprint Lrrk2 and Lewy body disease
    Owen A Ross
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Ann Neurol 59:388-93. 2006
    ..The Lrrk2 kinase domain G2019S substitution is the most common genetic basis of familial and sporadic parkinsonism. Patients harboring the G2019S substitution usually present with clinical Parkinson's disease...
  38. ncbi request reprint Ibogaine analogues. Synthesis and preliminary pharmacological evaluation of 7-heteroaryl-2-azabicyclo[2.2.2]oct-7-enes
    Daniele Passarella
    Dipartimento di Chimica Organica e Industriale, Universita degli Studi di Milano, via Venezian 21, 20133 Milan, Italy
    Bioorg Med Chem 11:1007-14. 2003
    ..2.2]oct-7-enes by cycloaddition and subsequent cross-coupling reaction is described. Binding affinity of these novel compounds towards the characteristic receptorial targets of ibogaine is illustrated...
  39. ncbi request reprint National Association of Medical Examiners position paper on the certification of cocaine-related deaths
    Boyd G Stephens
    Office of the Chief Medical Examiner, City and County of San Francisco, San Francisco, California 94103 4603, USA
    Am J Forensic Med Pathol 25:11-3. 2004
    ..These guidelines are intended for use by practicing medical examiners and physicians who certify drug deaths, as well as providing education tools for students...
  40. ncbi request reprint Hallucinations in multiple system atrophy
    Spiridon Papapetropoulos
    Parkinsonism Relat Disord 13:193-4. 2007
  41. ncbi request reprint The neurochemical mechanism of rebound psychosis in Parkinson's disease
    Spiridon Papapetropoulos
    Mov Disord 20:515; author reply 515. 2005
  42. ncbi request reprint Common human 5' dopamine transporter (SLC6A3) haplotypes yield varying expression levels in vivo
    Tomas Drgon
    Molecular Neurobiology Branch, NIDA IRP, NIH, DHSS, Box 5180, Baltimore, Maryland 21224, USA
    Cell Mol Neurobiol 26:875-89. 2006
    ..5' DAT variation is thus a good candidate to contribute to individual differences in a number of human phenotypes...
  43. ncbi request reprint Alpha-synuclein aggregation and its relation to neurodegenerative diseases
    Spiridon Papapetropoulos
    Ann Neurol 57:605; author reply 605-6. 2005
  44. ncbi request reprint Disparities in death certificates of Parkinson's disease patients: a report from a population of brain donors
    Spiridon Papapetropoulos
    Mov Disord 21:1791-2; author reply 1792. 2006
  45. ncbi request reprint MDMA self-administration in rats: acquisition, progressive ratio responding and serotonin transporter binding
    Susan Schenk
    Victoria University of Wellington, School of Psychology, Wellington, New Zealand
    Eur J Neurosci 26:3229-36. 2007
    ..These data support the idea that MDMA is a drug with high abuse liability, and long-term self-administration may lead to long-lasting deficits in serotonin neurotransmission...

Research Grants19

  1. CNS MECHANISMS IN COCAINE-RELATED SUDDEN DEATH
    Deborah C Mash; Fiscal Year: 2010
    ..A better understanding of how cocaine abuse affects the CNS will facilitate the development of more successful prevention and treatment strategies. ..
  2. CNS MECHANISMS IN COCAINE RELATED SUDDEN DEATH
    Deborah Mash; Fiscal Year: 2006
    ..Together, these studies will provide a molecular and circuit-based accounting of the abnormalities in biogenic amine systems in cocaine toxicity. ..
  3. Rapid Screening Method: Gamma-hydroxybutyrate Detection
    Deborah Mash; Fiscal Year: 2002
    ..Both of these methods will be tested on GHB-spiked controls and residual blood and urine specimens obtained from the Miami-Dade County Medical Examiner Department and the Emergency Department of Jackson Memorial Hospital. ..
  4. CNS MECHANISMS IN COCAINE RELATED SUDDEN DEATH
    Deborah Mash; Fiscal Year: 2001
    ....
  5. LIMBIC & MEDULLARY MECH. IN COCAINE-RELATED SUDDEN DEATH
    Deborah Mash; Fiscal Year: 1992
    ..These studies may provide a basis for pharmacologically targeting multiple, interactive dysfunctions in the brain in order to halt cocaine abuse in chronic users...
  6. CNS MECHANISMS IN COCAINE-RELATED SUDDEN DEATH
    Deborah Mash; Fiscal Year: 1993
    ....
  7. CNS MECHANISMS IN COCAINE-RELATED SUDDEN DEATH
    Deborah C Mash; Fiscal Year: 2010
    ..A better understanding of how cocaine abuse affects the CNS will facilitate the development of more successful prevention and treatment strategies. ..