J C G Marvizón

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Substance P release in the dorsal horn assessed by receptor internalization: NMDA receptors counteract a tonic inhibition by GABA(B) receptors
    J C Marvizon
    CURE Digestive Diseases Research Center, Department of Medicine, University of California, Los Angeles 90073, USA
    Eur J Neurosci 11:417-26. 1999
  2. pmc Enkephalins, dynorphins, and beta-endorphin in the rat dorsal horn: an immunofluorescence colocalization study
    Juan Carlos G Marvizon
    Center for the Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Comp Neurol 517:51-68. 2009
  3. pmc Calcitonin receptor-like receptor and receptor activity modifying protein 1 in the rat dorsal horn: localization in glutamatergic presynaptic terminals containing opioids and adrenergic alpha2C receptors
    J C G Marvizón
    Center for Neurovisceral Sciences and Women s Health and CURE Department of Medicine, David Geffen School of Medicine at UCLA and Veteran Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Neuroscience 148:250-65. 2007
  4. pmc Effect of peptidases on the ability of exogenous and endogenous neurokinins to produce neurokinin 1 receptor internalization in the rat spinal cord
    Juan Carlos G Marvizon
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Br J Pharmacol 140:1389-98. 2003
  5. ncbi request reprint Two N-methyl-D-aspartate receptors in rat dorsal root ganglia with different subunit composition and localization
    Juan Carlos G Marvizon
    Neuroenteric Disease Program, CURE Digestive Diseases Research Center, Department of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 446:325-41. 2002
  6. ncbi request reprint GABA(A) receptor facilitation of neurokinin release from primary afferent terminals in the rat spinal cord
    L Lao
    Center for Neurovisceral Sciences and Women s Health, CURE Digestive Diseases Research Center, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA
    Neuroscience 130:1013-27. 2005
  7. ncbi request reprint Neurokinin release produced by capsaicin acting on the central terminals and axons of primary afferents: relationship with N-methyl-D-aspartate and GABA(B) receptors
    L J Lao
    Center for Neurovisceral Sciences and Women s Health, CURE Digestive Diseases Research Center, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, 90095, USA
    Neuroscience 121:667-80. 2003
  8. pmc Substance P release and neurokinin 1 receptor activation in the rat spinal cord increase with the firing frequency of C-fibers
    D Adelson
    Veterans Affairs Greater Los Angeles Healthcare System, Building 115, Room 119, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Neuroscience 161:538-53. 2009
  9. pmc N-methyl-D-aspartate receptors and large conductance calcium-sensitive potassium channels inhibit the release of opioid peptides that induce mu-opioid receptor internalization in the rat spinal cord
    B Song
    Center for Neurovisceral Sciences and Women s Health and CURE Digestive Diseases Research Center, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Los Angeles, CA, USA
    Neuroscience 136:549-62. 2005
  10. pmc NMDA receptors in primary afferents require phosphorylation by Src family kinases to induce substance P release in the rat spinal cord
    W Chen
    Center for Neurobiology of Stress, CURE Digestive Diseases Research Center, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, USA
    Neuroscience 166:924-34. 2010

Research Grants

  1. SPINAL NEUROKININ AND OPIOID RELEASE IN NOCICEPTION
    Juan Carlos Marvizon; Fiscal Year: 2001
  2. SPINAL NEUROKININ AND OPIOID RELEASE IN NOCICEPTION
    Juan Carlos Marvizon; Fiscal Year: 2002
  3. SPINAL NEUROKININ AND OPIOID RELEASE IN NOCICEPTION
    Juan Carlos Marvizon; Fiscal Year: 2003
  4. SPINAL NEUROKININ AND OPIOID RELEASE IN NOCICEPTION
    Juan Carlos Marvizon; Fiscal Year: 2004
  5. SPINAL NEUROKININ AND OPIOID RELEASE IN NOCICEPTION
    Juan Carlos Marvizon; Fiscal Year: 2005
  6. Spinal Opioid Release in Nociception
    Juan Carlos Marvizon; Fiscal Year: 2006
  7. Spinal Opioid Release in Nociception
    Juan Carlos Marvizon; Fiscal Year: 2007

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Substance P release in the dorsal horn assessed by receptor internalization: NMDA receptors counteract a tonic inhibition by GABA(B) receptors
    J C Marvizon
    CURE Digestive Diseases Research Center, Department of Medicine, University of California, Los Angeles 90073, USA
    Eur J Neurosci 11:417-26. 1999
    ..Therefore, inhibition of substance P release by GABA(B) receptors is tonic, and in its absence SP release no longer requires NMDA receptor activation...
  2. pmc Enkephalins, dynorphins, and beta-endorphin in the rat dorsal horn: an immunofluorescence colocalization study
    Juan Carlos G Marvizon
    Center for the Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    J Comp Neurol 517:51-68. 2009
    ..These results show that enkephalins and dynorphins are present in different populations of dorsal horn neurons. In addition, dynorphin is present in some C-fibers...
  3. pmc Calcitonin receptor-like receptor and receptor activity modifying protein 1 in the rat dorsal horn: localization in glutamatergic presynaptic terminals containing opioids and adrenergic alpha2C receptors
    J C G Marvizón
    Center for Neurovisceral Sciences and Women s Health and CURE Department of Medicine, David Geffen School of Medicine at UCLA and Veteran Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Neuroscience 148:250-65. 2007
    ..These findings suggest that CGRP or adrenomedullin receptors modulate opioid release in the dorsal horn...
  4. pmc Effect of peptidases on the ability of exogenous and endogenous neurokinins to produce neurokinin 1 receptor internalization in the rat spinal cord
    Juan Carlos G Marvizon
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Br J Pharmacol 140:1389-98. 2003
    ..Therefore, NEN and DCP restrict NK1R activation by endogenous neurokinins when they are gradually released by low-frequency firing of primary afferents, but become saturated or inhibited when primary afferents fire at a high frequency...
  5. ncbi request reprint Two N-methyl-D-aspartate receptors in rat dorsal root ganglia with different subunit composition and localization
    Juan Carlos G Marvizon
    Neuroenteric Disease Program, CURE Digestive Diseases Research Center, Department of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 446:325-41. 2002
    ....
  6. ncbi request reprint GABA(A) receptor facilitation of neurokinin release from primary afferent terminals in the rat spinal cord
    L Lao
    Center for Neurovisceral Sciences and Women s Health, CURE Digestive Diseases Research Center, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA
    Neuroscience 130:1013-27. 2005
    ....
  7. ncbi request reprint Neurokinin release produced by capsaicin acting on the central terminals and axons of primary afferents: relationship with N-methyl-D-aspartate and GABA(B) receptors
    L J Lao
    Center for Neurovisceral Sciences and Women s Health, CURE Digestive Diseases Research Center, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, 90095, USA
    Neuroscience 121:667-80. 2003
    ..The first effect largely bypasses other modulatory mechanism, but the second does not...
  8. pmc Substance P release and neurokinin 1 receptor activation in the rat spinal cord increase with the firing frequency of C-fibers
    D Adelson
    Veterans Affairs Greater Los Angeles Healthcare System, Building 115, Room 119, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Neuroscience 161:538-53. 2009
    ..In conclusion, the instantaneous firing frequency in C-fibers determines the amount of substance P released by noxious stimuli...
  9. pmc N-methyl-D-aspartate receptors and large conductance calcium-sensitive potassium channels inhibit the release of opioid peptides that induce mu-opioid receptor internalization in the rat spinal cord
    B Song
    Center for Neurovisceral Sciences and Women s Health and CURE Digestive Diseases Research Center, Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Los Angeles, CA, USA
    Neuroscience 136:549-62. 2005
    ..Since mu-opioid receptors in the dorsal horn mediate analgesia, inhibition of spinal opioid release could contribute to the hyperalgesic actions of spinal N-methyl-D-aspartate receptors...
  10. pmc NMDA receptors in primary afferents require phosphorylation by Src family kinases to induce substance P release in the rat spinal cord
    W Chen
    Center for Neurobiology of Stress, CURE Digestive Diseases Research Center, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, CA, USA
    Neuroscience 166:924-34. 2010
    ..These results show that tyrosine-phosphorylation of these NMDA receptors is regulated by the opposite actions of Src family kinases and protein tyrosine phosphatases, and is required to induce substance P release...
  11. pmc Acute inflammation induces segmental, bilateral, supraspinally mediated opioid release in the rat spinal cord, as measured by mu-opioid receptor internalization
    W Chen
    Center for the Neurobiology of Stress, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuroscience 161:157-72. 2009
    ..These results show that acute inflammation, but not chronic inflammation, induces segmental opioid release in the spinal cord that involves supraspinal signals...
  12. pmc Cannabinoid CB1 receptor facilitation of substance P release in the rat spinal cord, measured as neurokinin 1 receptor internalization
    Guohua Zhang
    Veteran Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Eur J Neurosci 31:225-37. 2010
    ..This results in a pronociceptive effect of CB1 receptors in the spinal cord...
  13. ncbi request reprint Relationship between capsaicin-evoked substance P release and neurokinin 1 receptor internalization in the rat spinal cord
    J C G Marvizón
    Department of Medicine, David Geffen School of Medicine at UCLA, MRL 1240, 675 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 118:535-45. 2003
    ....
  14. pmc Selective knockdown of NMDA receptors in primary afferent neurons decreases pain during phase 2 of the formalin test
    J A McRoberts
    Center for Neurobiology of Stress, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuroscience 172:474-82. 2011
    ..001). There was no effect on phase 1 responses. These results suggest that NMDA receptors expressed by primary afferent nerves play an important role in the development of sensitized pain states...
  15. pmc Effects of veratridine and high potassium on micro-opioid receptor internalization in the rat spinal cord: stimulation of opioid release versus inhibition of internalization
    Wenling Chen
    Center for Neurobiology of Stress, CURE Digestive Diseases Research Center, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90073, United States
    J Neurosci Methods 170:285-93. 2008
    ..These results show that short incubations with 20 microM veratridine or 30 mM KCl are optimal stimuli to evoke opioid release and MOR internalization in the spinal cord...
  16. pmc Noxious mechanical stimulation evokes the segmental release of opioid peptides that induce mu-opioid receptor internalization in the presence of peptidase inhibitors
    Lijun Lao
    Center for Neurobiology of Stress and CURE Digestive Diseases Research Center, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Brain Res 1197:85-93. 2008
    ..These results show that mechanical stimulation induces segmental opioid release, i.e., in the dorsal horn receiving the noxious signals and not in other spinal segments...
  17. pmc Inhibition of opioid release in the rat spinal cord by alpha2C adrenergic receptors
    Wenling Chen
    Center for the Neurobiology of Stress and CURE Digestive Diseases Research Center, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuropharmacology 54:944-53. 2008
    ..These results show that alpha2C receptors inhibit the release of opioids in the dorsal horn. This action may serve to shut down the opioid system when the adrenergic system is active...
  18. pmc Dorsal horn neurons firing at high frequency, but not primary afferents, release opioid peptides that produce micro-opioid receptor internalization in the rat spinal cord
    Bingbing Song
    Center for Neurovisceral Sciences and Women s Health, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90073, USA
    J Neurosci 23:9171-84. 2003
    ..These findings demonstrate that some dorsal horn neurons release opioids when they fire at high frequencies, perhaps by integrating signals from the rostral ventromedial medulla, primary afferents, and other areas of the spinal cord...
  19. pmc μ-Opioid receptor inhibition of substance P release from primary afferents disappears in neuropathic pain but not inflammatory pain
    W Chen
    Veteran Affairs Greater Los Angeles Healthcare System, Los Angeles, CA 90073, United States Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA 90095, United States
    Neuroscience 267:67-82. 2014
    ..In conclusion, nerve injury eliminates the inhibition of substance P release by μ-opioid receptors, probably by hindering their signaling mechanisms. ..
  20. pmc Comparing analgesia and mu-opioid receptor internalization produced by intrathecal enkephalin: requirement for peptidase inhibition
    Wenling Chen
    Center for Neurovisceral Sciences and Women s Health and CURE Digestive Diseases Research Center, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA
    Neuropharmacology 53:664-76. 2007
    ..Since peptidases prevent the activation of spinal opioid receptors by enkephalins, the coincident release of opioids and endogenous peptidase inhibitors may be required for analgesia...
  21. pmc Inhibition of opioid release in the rat spinal cord by serotonin 5-HT(1A) receptors
    Bingbing Song
    Center for Neurovisceral Sciences and Women s Health and CURE Digestive Diseases Research Center, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Brain Res 1158:57-62. 2007
    ..Therefore, 5-HT(1A) receptors likely decrease the analgesia produced by endogenously released opioids...
  22. ncbi request reprint Time-course of the internalization and recycling of neurokinin 1 receptors in rat dorsal horn neurons
    Xueren Wang
    Neuroenteric Disease Program, CURE Digestive Diseases Research Center, Department of Medicine, University of California at Los Angeles, 90095, USA
    Brain Res 944:239-47. 2002
    ..These results show that NK1R internalization and recycling are considerably faster in dorsal horn neurons than in cultured cells, and that most NK1Rs in dorsal horn neurons are internalized when NK1R-mediated hyperalgesia is more severe...
  23. pmc Peptidases prevent mu-opioid receptor internalization in dorsal horn neurons by endogenously released opioids
    Bingbing Song
    Center for Neurovisceral Sciences and Women s Health, Division of Digestive Diseases, Department of Medicine, Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 23:1847-58. 2003
    ..These findings indicate that peptidases prevent the activation of extrasynaptic MOR-1 in dorsal horn neurons...

Research Grants8

  1. SPINAL NEUROKININ AND OPIOID RELEASE IN NOCICEPTION
    Juan Carlos Marvizon; Fiscal Year: 2001
    ..Once experimental conditions are refined in slices, they will be applied to studies ''n vivo'' to further test the hypotheses in the whole animal. ..
  2. SPINAL NEUROKININ AND OPIOID RELEASE IN NOCICEPTION
    Juan Carlos Marvizon; Fiscal Year: 2002
    ..Once experimental conditions are refined in slices, they will be applied to studies ''n vivo'' to further test the hypotheses in the whole animal. ..
  3. SPINAL NEUROKININ AND OPIOID RELEASE IN NOCICEPTION
    Juan Carlos Marvizon; Fiscal Year: 2003
    ..Once experimental conditions are refined in slices, they will be applied to studies ''n vivo'' to further test the hypotheses in the whole animal. ..
  4. SPINAL NEUROKININ AND OPIOID RELEASE IN NOCICEPTION
    Juan Carlos Marvizon; Fiscal Year: 2004
    ..Once experimental conditions are refined in slices, they will be applied to studies ''n vivo'' to further test the hypotheses in the whole animal. ..
  5. SPINAL NEUROKININ AND OPIOID RELEASE IN NOCICEPTION
    Juan Carlos Marvizon; Fiscal Year: 2005
    ..The neural pathways involved will be studied using selective spinal cord lesions. ..
  6. Spinal Opioid Release in Nociception
    Juan Carlos Marvizon; Fiscal Year: 2006
    ..The neural pathways involved will be studied using selective spinal cord lesions. ..
  7. Spinal Opioid Release in Nociception
    Juan Carlos Marvizon; Fiscal Year: 2007
    ..The neural pathways involved will be studied using selective spinal cord lesions. ..