Anatoly E Martynyuk

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. doi request reprint Animal models of brain dysfunction in phenylketonuria
    A E Martynyuk
    Department of Anesthesiology and the McKnight Brain Institute, University of Florida, PO Box 100254, JHMHC, 1600 SW Archer Road, Gainesville, FL 32610 0254, USA
    Mol Genet Metab 99:S100-5. 2010
  2. ncbi request reprint Epilepsy in phenylketonuria: a complex dependence on serum phenylalanine levels
    Anatoly E Martynyuk
    Department of Anesthesiology, University of Florida, Gainesville, FL 32610 0254, USA
    Epilepsia 48:1143-50. 2007
  3. ncbi request reprint Impaired glutamatergic synaptic transmission in the PKU brain
    A E Martynyuk
    Department of Anesthesiology, University of Florida, Gainesville, FL, USA
    Mol Genet Metab 86:S34-42. 2005
  4. ncbi request reprint Halogenated derivatives of aromatic amino acids exhibit balanced antiglutamatergic actions: potential applications for the treatment of neurological and neuropsychiatric disorders
    Anatoly E Martynyuk
    Department of Anesthesiology, University of Florida, Gainesville, Florida 32610 0254, USA
    Recent Pat CNS Drug Discov 1:261-70. 2006
  5. ncbi request reprint Potentiation of the negative dromotropic effect of adenosine by rapid heart rates: possible ionic mechanism
    Anatoly E Martynyuk
    Department of Anesthesiology, University of Florida, Gainesville, Florida 32610 0254, USA
    Basic Res Cardiol 97:295-304. 2002
  6. ncbi request reprint Neuroprotective action of halogenated derivatives of L-phenylalanine
    Tomoko Kagiyama
    Department of Anesthesiology, University of Florida, Gainesville, Fla 32610 0254, USA
    Stroke 35:1192-6. 2004
  7. ncbi request reprint Basal and angiotensin II-inhibited neuronal delayed-rectifier K+ current are regulated by thioredoxin
    Tomokazu Matsuura
    Dept of Physiology and Functional Genomics, College of Medicine, University of Florida, Box 100274, 1600 SW Archer Rd, Gainesville, FL 32610 0274, USA
    Am J Physiol Cell Physiol 293:C211-7. 2007
  8. doi request reprint Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures
    Wengang Cao
    Department of Anesthesiology, University of Florida, Gainesville, FL, 32610 0254, USA
    Amino Acids 40:1151-8. 2011
  9. ncbi request reprint Free radicals potentiate the negative dromotropic effect of adenosine in guinea pig isolated heart
    Surender Rajasekaran
    Department of Anaesthesiology, University of Florida, Gainesville, FL 32610 0254, USA
    Acta Cardiol 58:191-7. 2003
  10. pmc Roles of aldosterone and oxytocin in abnormalities caused by sevoflurane anesthesia in neonatal rats
    Wengang Cao
    Department of Anesthesiology, University of Florida, Gainesville, Florida 32610 0254, USA
    Anesthesiology 117:791-800. 2012

Collaborators

  • Viktor Yarotskyy
  • Paul R Carney
  • Mehmet S Ozcan
  • M Ian Phillips
  • C Sumners
  • Hajime Nakamura
  • Christoph N Seubert
  • Wengang Cao
  • Tomokazu Matsuura
  • Nikolaus Gravenstein
  • Christopher Pavlinec
  • Hina P Shah
  • David A Edwards
  • Tomoko Kagiyama
  • Donn M Dennis
  • Surender Rajasekaran
  • Wanting Zhu
  • Adam P Mecca
  • Peng Shi
  • Alexander Glushakov
  • Andrew D Westwell
  • Rachael A Harrison
  • Aphrodite Kapurniotu
  • Jurgen Bernhagen
  • Chengwen Sun
  • Richard Bucala
  • Lin Leng
  • Alexander V Glushakov
  • Brandy Roose
  • Timothy E Morey

Detail Information

Publications14

  1. doi request reprint Animal models of brain dysfunction in phenylketonuria
    A E Martynyuk
    Department of Anesthesiology and the McKnight Brain Institute, University of Florida, PO Box 100254, JHMHC, 1600 SW Archer Road, Gainesville, FL 32610 0254, USA
    Mol Genet Metab 99:S100-5. 2010
    ..A better understanding of these mechanisms will guide the development of optimal treatment strategies for PKU...
  2. ncbi request reprint Epilepsy in phenylketonuria: a complex dependence on serum phenylalanine levels
    Anatoly E Martynyuk
    Department of Anesthesiology, University of Florida, Gainesville, FL 32610 0254, USA
    Epilepsia 48:1143-50. 2007
    ..Phenylketonuria (PKU) is a disorder of phenylalanine (Phe) metabolism that frequently results in epilepsy if a low Phe diet was not implemented at birth. The mechanisms by which Phe affects the brain are poorly understood...
  3. ncbi request reprint Impaired glutamatergic synaptic transmission in the PKU brain
    A E Martynyuk
    Department of Anesthesiology, University of Florida, Gainesville, FL, USA
    Mol Genet Metab 86:S34-42. 2005
    ....
  4. ncbi request reprint Halogenated derivatives of aromatic amino acids exhibit balanced antiglutamatergic actions: potential applications for the treatment of neurological and neuropsychiatric disorders
    Anatoly E Martynyuk
    Department of Anesthesiology, University of Florida, Gainesville, Florida 32610 0254, USA
    Recent Pat CNS Drug Discov 1:261-70. 2006
    ..The properties of this class of compounds and relevant patents are reviewed in this article...
  5. ncbi request reprint Potentiation of the negative dromotropic effect of adenosine by rapid heart rates: possible ionic mechanism
    Anatoly E Martynyuk
    Department of Anesthesiology, University of Florida, Gainesville, Florida 32610 0254, USA
    Basic Res Cardiol 97:295-304. 2002
    ....
  6. ncbi request reprint Neuroprotective action of halogenated derivatives of L-phenylalanine
    Tomoko Kagiyama
    Department of Anesthesiology, University of Florida, Gainesville, Fla 32610 0254, USA
    Stroke 35:1192-6. 2004
    ..Therefore, we hypothesized that endogenous derivatives of L-Phe, which display potent antiglutamatergic activity, may safely and efficaciously protect the brain during conditions characterized by overactivation of glutamate receptors...
  7. ncbi request reprint Basal and angiotensin II-inhibited neuronal delayed-rectifier K+ current are regulated by thioredoxin
    Tomokazu Matsuura
    Dept of Physiology and Functional Genomics, College of Medicine, University of Florida, Box 100274, 1600 SW Archer Rd, Gainesville, FL 32610 0274, USA
    Am J Physiol Cell Physiol 293:C211-7. 2007
    ..Moreover, these data suggest that TPOR may be a general mechanism for negatively regulating neuronal activity...
  8. doi request reprint Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures
    Wengang Cao
    Department of Anesthesiology, University of Florida, Gainesville, FL, 32610 0254, USA
    Amino Acids 40:1151-8. 2011
    ....
  9. ncbi request reprint Free radicals potentiate the negative dromotropic effect of adenosine in guinea pig isolated heart
    Surender Rajasekaran
    Department of Anaesthesiology, University of Florida, Gainesville, FL 32610 0254, USA
    Acta Cardiol 58:191-7. 2003
    ..Adenosine is released during myocardial ischaemia and delays atrioventricular nodal (AV) conduction. We hypothesized that free radicals present during reperfusion potentiate the negative dromotropic effect of adenosine on the AV node...
  10. pmc Roles of aldosterone and oxytocin in abnormalities caused by sevoflurane anesthesia in neonatal rats
    Wengang Cao
    Department of Anesthesiology, University of Florida, Gainesville, Florida 32610 0254, USA
    Anesthesiology 117:791-800. 2012
    ..The authors sought to determine whether subjects with pathophysiological conditions that are characterized by increased concentrations of aldosterone have increased susceptibility to the side effects of neonatal anesthesia with sevoflurane...
  11. doi request reprint Bumetanide alleviates epileptogenic and neurotoxic effects of sevoflurane in neonatal rat brain
    David A Edwards
    Department of Anesthesiology, University of Florida, Gainesville, Florida 32610 0254, USA
    Anesthesiology 112:567-75. 2010
    ..We tested the hypothesis that in newborn rats, sevoflurane may cause seizures, neurotoxicity, and impairment in synaptic plasticity-effects that may be diminished by the Na-K-2Cl cotransporter 1 inhibitor, bumetanide...
  12. doi request reprint Developmental effects of neonatal isoflurane and sevoflurane exposure in rats
    Christoph N Seubert
    Department of Anesthesiology, University of Florida, Gainesville, Florida 32610 0254, USA
    Anesthesiology 119:358-64. 2013
    ..The authors sought to determine whether these differences can also be detected at the level of neurodevelopmental effects...
  13. ncbi request reprint Macrophage migration inhibitory factor increases neuronal delayed rectifier K+ current
    Tomokazu Matsuura
    Department of Physiology and Functional Genomics and McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0274, USA
    J Neurophysiol 95:1042-8. 2006
    ..These studies indicate that the neuronal action of MIF includes a stimulatory action on I(Kv) that may be mediated by a TPOR/superoxide-scavenging mechanism...
  14. ncbi request reprint Contribution of I(K,ADO) to the negative dromotropic effect of adenosine
    Anatoly E Martynyuk
    Department of Anesthesiology, University of Florida, Gainesville, Florida 32610 0254, USA
    Basic Res Cardiol 97:286-94. 2002
    ..Therefore, we studied the contribution of I(K,ADO) to the negative dromotropic effect of adenosine...