Jesse D Martinez

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc Restoring p53 tumor suppressor activity as an anticancer therapeutic strategy
    Jesse D Martinez
    University of Arizona, Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    Future Oncol 6:1857-62. 2010
  2. pmc Using logistic regression to improve the prognostic value of microarray gene expression data sets: application to early-stage squamous cell carcinoma of the lung and triple negative breast carcinoma
    David W Mount
    Department of Cellular and Molecular Medicine, Arizona Health Sciences Center, The University of Arizona, Tucson, Arizona 85735, USA
    BMC Med Genomics 7:33. 2014
  3. pmc Human 14-3-3 gamma protein results in abnormal cell proliferation in the developing eye of Drosophila melanogaster
    Sophia W Hong
    Department of Cell Biology and Anatomy, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    Cell Div 3:2. 2008
  4. ncbi request reprint Free radicals generated by ionizing radiation signal nuclear translocation of p53
    J D Martinez
    Department of Radiation Oncology, University of Arizona, Tucson 85724, USA
    Cell Growth Differ 8:941-9. 1997
  5. ncbi request reprint 14-3-3 proteins: do they have a role in human cancer?
    Jesse D Martinez
    University of Arizona, Arizona Cancer Center and Department of Cell Biology and Anatomy, Tucson, AZ 85724, USA
    Future Oncol 1:631-3. 2005
  6. ncbi request reprint Different bile acids exhibit distinct biological effects: the tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation
    J D Martinez
    Department of Radiation Oncology, Arizona Cancer Center, Tucson 85724, USA
    Nutr Cancer 31:111-8. 1998
  7. pmc Resistance to ursodeoxycholic acid-induced growth arrest can also result in resistance to deoxycholic acid-induced apoptosis and increased tumorgenicity
    Ashley A Powell
    Cancer Biology Interdisciplinary Program, University of Arizona, Arizona Cancer Center, Tucson, AZ 85724, USA
    BMC Cancer 6:219. 2006
  8. pmc P53 suppresses expression of the 14-3-3 gamma oncogene
    Vijayababu M Radhakrishnan
    Arizona Cancer Center, Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona 85724, USA
    BMC Cancer 11:378. 2011
  9. pmc 14-3-3gamma induces oncogenic transformation by stimulating MAP kinase and PI3K signaling
    Vijayababu M Radhakrishnan
    Arizona Cancer Center, Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 5:e11433. 2010
  10. ncbi request reprint Overexpression of 14-3-3gamma causes polyploidization in H322 lung cancer cells
    Wenqing Qi
    Arizona Cancer Center, Department of Cell Biology and Anatomy, 1515 N Campbell Ave, University of Arizona, Tucson, Arizona 85724, USA
    Mol Carcinog 46:847-56. 2007

Research Grants

  1. Genetic analysis of p53 activation
    Jesse Martinez; Fiscal Year: 2003
  2. The Role of p53 and 14-3-3 in Genomic Instability
    Jesse Martinez; Fiscal Year: 2007
  3. Genetic analysis of p53 activation
    Jesse Martinez; Fiscal Year: 2006
  4. The Role of p53 and 14-3-3 in Genomic Instability
    Jesse Martinez; Fiscal Year: 2006
  5. Genetic analysis of p53 activation
    Jesse Martinez; Fiscal Year: 2005
  6. The Role of p53 and 14-3-3 in Genomic Instability
    Jesse Martinez; Fiscal Year: 2005
  7. Genetic analysis of p53 activation
    Jesse Martinez; Fiscal Year: 2004
  8. The Role of p53 and 14-3-3 in Genomic Instability
    Jesse Martinez; Fiscal Year: 2004
  9. Mechanisms of colon cancer chemoprevention by ursodeoxycholic acid
    Jesse D Martinez; Fiscal Year: 2010

Collaborators

Detail Information

Publications37

  1. pmc Restoring p53 tumor suppressor activity as an anticancer therapeutic strategy
    Jesse D Martinez
    University of Arizona, Arizona Cancer Center, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    Future Oncol 6:1857-62. 2010
    ..In this article, we review the strategies for restoring p53 function and some of the new compounds that show promise as antitumor agents in preclinical models...
  2. pmc Using logistic regression to improve the prognostic value of microarray gene expression data sets: application to early-stage squamous cell carcinoma of the lung and triple negative breast carcinoma
    David W Mount
    Department of Cellular and Molecular Medicine, Arizona Health Sciences Center, The University of Arizona, Tucson, Arizona 85735, USA
    BMC Med Genomics 7:33. 2014
    ..A similar analysis was applied to a data set of triple negative breast carcinoma cases, which present similar clinical challenges...
  3. pmc Human 14-3-3 gamma protein results in abnormal cell proliferation in the developing eye of Drosophila melanogaster
    Sophia W Hong
    Department of Cell Biology and Anatomy, Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    Cell Div 3:2. 2008
    ..However, the mechanism through which these proteins act in tumorigenesis is uncertain...
  4. ncbi request reprint Free radicals generated by ionizing radiation signal nuclear translocation of p53
    J D Martinez
    Department of Radiation Oncology, University of Arizona, Tucson 85724, USA
    Cell Growth Differ 8:941-9. 1997
    ..We suggest that the free radicals generated by ionizing radiation can signal p53 translocation to the nucleus...
  5. ncbi request reprint 14-3-3 proteins: do they have a role in human cancer?
    Jesse D Martinez
    University of Arizona, Arizona Cancer Center and Department of Cell Biology and Anatomy, Tucson, AZ 85724, USA
    Future Oncol 1:631-3. 2005
    ..Since biochemical studies suggest that 14-3-3 proteins regulate multiple pathways that are also disrupted during tumorigenesis, it is unclear how they actually contribute to tumor development...
  6. ncbi request reprint Different bile acids exhibit distinct biological effects: the tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation
    J D Martinez
    Department of Radiation Oncology, Arizona Cancer Center, Tucson 85724, USA
    Nutr Cancer 31:111-8. 1998
    ..These results indicate that different bile acids exhibit distinct biological activities and suggest that the cytotoxicity reported for DCA may be due to its capacity to induce apoptosis via a protein kinase C-dependent signaling pathway...
  7. pmc Resistance to ursodeoxycholic acid-induced growth arrest can also result in resistance to deoxycholic acid-induced apoptosis and increased tumorgenicity
    Ashley A Powell
    Cancer Biology Interdisciplinary Program, University of Arizona, Arizona Cancer Center, Tucson, AZ 85724, USA
    BMC Cancer 6:219. 2006
    ..The present study was carried out to determine whether there is overlap in signaling pathways activated by tumorogenic bile acid DCA and chemopreventive bile acid UDCA...
  8. pmc P53 suppresses expression of the 14-3-3 gamma oncogene
    Vijayababu M Radhakrishnan
    Arizona Cancer Center, Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arizona 85724, USA
    BMC Cancer 11:378. 2011
    ..We previously showed that one of the 14-3-3 family members, 14-3-3 gamma, is over expressed in human lung cancers and that it can induce transformation of rodent cells in vitro...
  9. pmc 14-3-3gamma induces oncogenic transformation by stimulating MAP kinase and PI3K signaling
    Vijayababu M Radhakrishnan
    Arizona Cancer Center, Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona, United States of America
    PLoS ONE 5:e11433. 2010
    ..Overall, our studies establish 14-3-3gamma as an oncogene and implicate MAPK and PI3K signaling as important for 14-3-3gamma induced transformation...
  10. ncbi request reprint Overexpression of 14-3-3gamma causes polyploidization in H322 lung cancer cells
    Wenqing Qi
    Arizona Cancer Center, Department of Cell Biology and Anatomy, 1515 N Campbell Ave, University of Arizona, Tucson, Arizona 85724, USA
    Mol Carcinog 46:847-56. 2007
    ..Taken together, our data indicate that 14-3-3gamma may contribute to tumorigenesis by promoting genomic instability...
  11. ncbi request reprint Isoform-specific expression of 14-3-3 proteins in human lung cancer tissues
    Wenqing Qi
    Arizona Cancer Center, Department of Cell Biology and Anatomy, The University of Arizona, Tucson, AZ 85724, USA
    Int J Cancer 113:359-63. 2005
    ....
  12. pmc Hsf1 is required for the nuclear translocation of p53 tumor suppressor
    Qiang Li
    Department of Cell Biology and Anatomy, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724 5024, USA
    Neoplasia 10:1138-45. 2008
    ..Collectively, our result suggests that Hsf1 is required for p53 nuclear importation and activation and implies that heat shock factors play a role in the regulation of p53...
  13. doi request reprint Transient dephosphorylation of p53 serine 376 as an early response to ionizing radiation
    Raymond L Warters
    Department of Radiation Oncology, University of Utah Health Sciences Center, Salt Lake City, Utah 84132, USA
    Radiat Res 171:725-34. 2009
    ..The data suggest that dephosphorylation of serine 376 on constitutive nuclear p53 is a sensitive and early signaling event in the response of cells to DNA damage induced by ionizing radiation...
  14. ncbi request reprint Ursodeoxycholic acid modulates histone acetylation and induces differentiation and senescence
    Sandeep Akare
    Department of Cell Biology and Anatomy, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Int J Cancer 119:2958-69. 2006
    ..In summary, our data shows that UDCA modulates chromatin by inducing histone hypoacetylation and induces differentiation and senescence in colon cancer cells...
  15. ncbi request reprint Deoxycholic acid induces intracellular signaling through membrane perturbations
    Samira Jean-Louis
    Cancer Biology Interdisciplinary Program, Arizona Cancer Center, University of Arizona, Tucson, AZ, USA
    J Biol Chem 281:14948-60. 2006
    ..Collectively, these data suggest that bile acid-induced signaling is initiated through alterations of the plasma membrane structure and the redistribution of cholesterol...
  16. ncbi request reprint Ursodeoxycholic acid can suppress deoxycholic acid-induced apoptosis by stimulating Akt/PKB-dependent survival signaling
    Eunok Im
    Arizona Cancer Center, Department of Cell Biology and Anatomy, University of Arizona, Tucson, Arizona 85724, USA
    Nutr Cancer 51:110-6. 2005
    ..These results suggest that UDCA can protect HCT116 cells against DCA-induced apoptosis by stimulating Akt-dependent survival signaling...
  17. ncbi request reprint Reduction of 14-3-3 proteins correlates with increased sensitivity to killing of human lung cancer cells by ionizing radiation
    Wenqing Qi
    Department of Radiation Oncology, The University of Arizona, and Arizona Cancer Center, Tucson, Arizona 85724, USA
    Radiat Res 160:217-23. 2003
    ..These data indicate that 14-3-3zeta is involved in G(2) checkpoint activation and that inhibition of 14-3-3 may be a useful approach to sensitize human lung cancers to ionizing radiation...
  18. pmc Activation of phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signaling and the consequent induction of transformation by overexpressed 14-3-3γ protein require specific amino acids within 14-3-3γ N-terminal variable region
    Vijayababu M Radhakrishnan
    Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    J Biol Chem 287:43300-11. 2012
    ..Our observations suggest that isoform-specific phenotypes are dictated by a relatively few amino acids within variable regions...
  19. pmc Loss of HSF1 results in defective radiation-induced G(2) arrest and DNA repair
    Qiang Li
    Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    Radiat Res 176:17-24. 2011
    ..Taken together our results indicate that HSF1 plays an important role in checkpoint activation and DNA repair and suggest that there is overlap between the heat stress response pathway and the pathway that responds to ionizing radiation...
  20. pmc Hypomethylation of the 14-3-3σ promoter leads to increased expression in non-small cell lung cancer
    Vijayababu M Radhakrishnan
    Arizona Cancer Center, 1515 N Campbell Ave, Tucson, Arizona 85724, USA
    Genes Chromosomes Cancer 50:830-6. 2011
    ..And also no mutations were found in 14-3-3σ gene. Overall, our data suggest that misregulated expression of 14-3-3σ gene may be due to altered methylation status. © 2011 Wiley-Liss, Inc...
  21. ncbi request reprint Ursodeoxycholic acid (UDCA) can inhibit deoxycholic acid (DCA)-induced apoptosis via modulation of EGFR/Raf-1/ERK signaling in human colon cancer cells
    Eunok Im
    Arizona Cancer Center, Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724, USA
    J Nutr 134:483-6. 2004
    ..Collectively, these findings suggest that the inhibitory effect of UDCA in DCA-induced apoptosis is partly mediated by modulation of EGFR/Raf-1/ERK signaling...
  22. pmc Different mutant/wild-type p53 combinations cause a spectrum of increased invasive potential in nonmalignant immortalized human mammary epithelial cells
    Damian J Junk
    Cancer Biology Graduate Interdisciplinary Program, The University of Arizona, Tucson, AZ 85724, USA
    Neoplasia 10:450-61. 2008
    ..These changes may constitute novel biomarkers or reveal novel treatment modalities that could inhibit progression from primary to metastatic breast disease...
  23. pmc Growth suppression by ursodeoxycholic acid involves caveolin-1 enhanced degradation of EGFR
    Rebecca Feldman
    Cancer Biology Graduate Program, University of Arizona, Tucson, AZ 85724, USA
    Biochim Biophys Acta 1793:1387-94. 2009
    ..Taken together these results suggest that UDCA may act to suppress cell growth by inhibiting the mitogenic activity of receptor tyrosine kinases such as EGFR through increased receptor degradation...
  24. ncbi request reprint Bile acid induces hydrophobicity-dependent membrane alterations
    Sandeep Akare
    Arizona Cancer Center, Department of Cell Biology and Anatomy, University of Arizona, 1515 N Campbell Avenue, Tucson, Arizona 85724, United States
    Biochim Biophys Acta 1735:59-67. 2005
    ....
  25. ncbi request reprint Time and dose-dependent radiosensitization of the glioblastoma multiforme U251 cells by the EGF receptor tyrosine kinase inhibitor ZD1839 ('Iressa')
    Baldassarre Stea
    Department of Radiation Oncology, Arizona Cancer Center, University of Arizona, 1501 N Campbell Ave, Tucson, AZ 85724, USA
    Cancer Lett 202:43-51. 2003
    ..Dose and schedule of drug administration in combination with radiation appeared to be a crucial element to obtain radiosensitization of the cells. These studies suggest novel therapeutic strategies in the treatment of GBM...
  26. pmc P53 is transported into the nucleus via an Hsf1-dependent nuclear localization mechanism
    Qiang Li
    Arizona Cancer Center, University of Arizona, Tucson, Arizona 85724, USA
    Mol Carcinog 50:143-52. 2011
    ..Hence, loss of Hsf1 activity not only suppressed p53 function, but also led to reduced sensitivity to killing by drugs that target microtubules...
  27. pmc Global mapping of gene/protein interactions in PubMed abstracts: a framework and an experiment with P53 interactions
    Xin Li
    Artificial Intelligence Lab, Department of Management Information Systems, The University of Arizona, McClelland Hall, Tucson, AZ 85721 0108, USA
    J Biomed Inform 40:453-64. 2007
    ..Temporal analysis showed that genes interacting with many other genes tend to be involved in a large number of newly discovered interactions...
  28. pmc The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent
    L Whitesell
    Department of Pediatrics and Steele Memorial Children s Research Center, University of Arizona, Tucson 85724, USA
    Mol Cell Biol 18:1517-24. 1998
    ..GA did not, however, appear to restore wild-type transcriptional activating activity to mutant p53 proteins in either A1-5 cells or human breast cancer cell lines...
  29. ncbi request reprint Loss of p53 and overexpression of EphA2 predict poor prognosis for ovarian cancer patients
    Linda Meade-Tollin
    Department of Surgery, Arizona Cancer Center, University of Arizona College of Medicine, 1501 North Campbell Avenue, Tucson, AZ 85724, USA
    Cancer Biol Ther 6:288-9. 2007
  30. pmc pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1)
    Vijayababu M Radhakrishnan
    Department of Pediatrics, Steele Children s Research Center, University of Arizona Health Sciences Center, Tucson, Arizona, United States of America
    PLoS ONE 9:e85796. 2014
    ....
  31. ncbi request reprint A shallow parser based on closed-class words to capture relations in biomedical text
    Gondy Leroy
    Management Information Systems, The University of Arizona, McClelland Hall, Room 430, 1130 E Helen St, Tucson, AZ 85721, USA
    J Biomed Inform 36:145-58. 2003
    ..There were 296 relations correctly extracted from the abstracts resulting in 90% precision of the relations and an average of 11 correct relations per abstract...
  32. pmc Bile acid hydrophobicity is correlated with induction of apoptosis and/or growth arrest in HCT116 cells
    A A Powell
    University of Arizona, Arizona Cancer Center, P.O. Box 245024, 1515 North Campbell Avenue, Tucson, AZ 85724, USA
    Biochem J 356:481-6. 2001
    ..These experiments suggest that hydrophobicity is an important determinant of the biological activity exhibited by bile acids but that under our conditions these activities are not correlated with cellular uptake...
  33. ncbi request reprint Deoxycholic acid suppresses p53 by stimulating proteasome-mediated p53 protein degradation
    D Qiao
    Arizona Cancer Center, Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724, USA
    Carcinogenesis 22:957-64. 2001
    ..Both ERK and PKC signaling have been previously demonstrated to be stimulated by DCA. These results suggest a novel signaling mechanism of bile acids that may play an important role in colon tumor promotion mediated by bile acids...
  34. ncbi request reprint Caffeine induces TP53-independent G(1)-phase arrest and apoptosis in human lung tumor cells in a dose-dependent manner
    Wenqing Qi
    Department of Radiation Oncology, The University of Arizona, 1501 N Campbell Avenue, P O Box 245024, Tucson, Arizona 85724, USA
    Radiat Res 157:166-74. 2002
    ..These data indicate that the effect of caffeine on cell cycle checkpoints and apoptosis is dependent on dose and that caffeine acts through differential regulation of cyclin-dependent kinase activity...
  35. ncbi request reprint Morphologic conversion of a neuroblastoma-derived cell line by E6-mediated p53 degradation
    S V Gaitonde
    Cancer Biology Interdisciplinary Program, and Arizona Cancer Center, Department of Radiation Oncology, University of Arizona, Tucson 85724, USA
    Cell Growth Differ 12:19-27. 2001
    ..These results suggest that p53 is required for the maintenance of the neuroblastic tumorigenic phenotype...
  36. pmc Genetic analysis of p53 nuclear importation
    Q Li
    Department of Cell Biology and Anatomy, Arizona Cancer Center, University of Arizona, Tucson, AZ 85724, USA
    Oncogene 26:7885-93. 2007
    ..Collectively, our results suggest that there is a p53 NLS-selective nuclear import pathway and that both soluble and insoluble proteins are involved in its function...
  37. ncbi request reprint Activator protein-1 and CCAAT/enhancer-binding protein mediated GADD153 expression is involved in deoxycholic acid-induced apoptosis
    Dianhua Qiao
    Department of Pathology and Laboratory Medicine, University of Wisconsin Madison, 53792 8550, USA
    Biochim Biophys Acta 1583:108-16. 2002
    ..These results suggest that GADD153 expression is critical for DCA-induced apoptosis and that multiple signaling pathways that include AP-1 and C/EBP transcription factors are involved in DCA-induced GADD153 expression...

Research Grants10

  1. Genetic analysis of p53 activation
    Jesse Martinez; Fiscal Year: 2003
    ..abstract_text> ..
  2. The Role of p53 and 14-3-3 in Genomic Instability
    Jesse Martinez; Fiscal Year: 2007
    ....
  3. Genetic analysis of p53 activation
    Jesse Martinez; Fiscal Year: 2006
    ..abstract_text> ..
  4. The Role of p53 and 14-3-3 in Genomic Instability
    Jesse Martinez; Fiscal Year: 2006
    ....
  5. Genetic analysis of p53 activation
    Jesse Martinez; Fiscal Year: 2005
    ..abstract_text> ..
  6. The Role of p53 and 14-3-3 in Genomic Instability
    Jesse Martinez; Fiscal Year: 2005
    ....
  7. Genetic analysis of p53 activation
    Jesse Martinez; Fiscal Year: 2004
    ..abstract_text> ..
  8. The Role of p53 and 14-3-3 in Genomic Instability
    Jesse Martinez; Fiscal Year: 2004
    ....
  9. Mechanisms of colon cancer chemoprevention by ursodeoxycholic acid
    Jesse D Martinez; Fiscal Year: 2010
    ....