Fernando J Martinez

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation
    Helene Skjøt-Arkil
    Nordic Bioscience A S, DK 2730, Herlev, Denmark
    BMC Pulm Med 12:34. 2012
  2. doi request reprint Fluticasone furoate/vilanterol (100/25; 200/25 μg) improves lung function in COPD: a randomised trial
    Fernando J Martinez
    University of Michigan, Ann Arbor, MI, USA
    Respir Med 107:550-9. 2013
  3. pmc Reduction of exacerbations by the PDE4 inhibitor roflumilast--the importance of defining different subsets of patients with COPD
    Stephen I Rennard
    Nebraska Medical Center, Omaha, Nebraska, USA
    Respir Res 12:18. 2011
  4. ncbi request reprint Acute exacerbation of chronic bronchitis: expanding short-course therapy
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, USA
    Int J Antimicrob Agents 26:S156-63. 2005
  5. ncbi request reprint Is it asthma or COPD? The answer determines proper therapy for chronic airflow obstruction
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, University of Michigan Medical School, Ann Arbor 48109, USA
    Postgrad Med 117:19-26. 2005
  6. ncbi request reprint The clinical course of patients with idiopathic pulmonary fibrosis
    Fernando J Martinez
    University of Michigan, Ann Arbor, Michigan 48109, USA
    Ann Intern Med 142:963-7. 2005
  7. pmc Course of FEV(1) after onset of bronchiolitis obliterans syndrome in lung transplant recipients
    Vibha N Lama
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 1500 East Medical Center Drive, 3916 Taubman Center, Ann Arbor, MI 48109 0360, USA
    Am J Respir Crit Care Med 175:1192-8. 2007
  8. doi request reprint Clinical significance of radiologic characterizations in COPD
    MeiLan K Han
    University of Michigan Health System, Ann Arbor, Michigan 48109 5360, USA
    COPD 6:459-67. 2009
  9. pmc Mesenchymal stromal cells in bronchoalveolar lavage as predictors of bronchiolitis obliterans syndrome
    Linda Badri
    1500 East Medical Center Drive, 3916 Taubman Center, Ann Arbor, MI 48109 0360, USA
    Am J Respir Crit Care Med 183:1062-70. 2011
  10. ncbi request reprint Idiopathic interstitial pneumonia: what is the effect of a multidisciplinary approach to diagnosis?
    Kevin R Flaherty
    Division of Pulmonary and Critical Care Medicine, Department of Radiology, University of Michigan Health System, 3916 Taubman Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0360, USA
    Am J Respir Crit Care Med 170:904-10. 2004

Detail Information

Publications108 found, 100 shown here

  1. pmc Measurement of MMP-9 and -12 degraded elastin (ELM) provides unique information on lung tissue degradation
    Helene Skjøt-Arkil
    Nordic Bioscience A S, DK 2730, Herlev, Denmark
    BMC Pulm Med 12:34. 2012
    ..Thus, we hypothesized that a MMP-9/-12 generated fragment of elastin may be a relevant biochemical maker for lung diseases...
  2. doi request reprint Fluticasone furoate/vilanterol (100/25; 200/25 μg) improves lung function in COPD: a randomised trial
    Fernando J Martinez
    University of Michigan, Ann Arbor, MI, USA
    Respir Med 107:550-9. 2013
    ..However, the dose of inhaled corticosteroid to use in a once-daily combination is unknown. We compared two strengths of fluticasone furoate (FF) plus vilanterol (VI), the same strengths of the individual components, and placebo...
  3. pmc Reduction of exacerbations by the PDE4 inhibitor roflumilast--the importance of defining different subsets of patients with COPD
    Stephen I Rennard
    Nebraska Medical Center, Omaha, Nebraska, USA
    Respir Res 12:18. 2011
    ..This led to the question of whether a responsive subset existed that could be investigated further...
  4. ncbi request reprint Acute exacerbation of chronic bronchitis: expanding short-course therapy
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, USA
    Int J Antimicrob Agents 26:S156-63. 2005
    ..The potential role of this preparation and other macrolides in patients at higher risk of therapeutic failure requires additional prospective data...
  5. ncbi request reprint Is it asthma or COPD? The answer determines proper therapy for chronic airflow obstruction
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, University of Michigan Medical School, Ann Arbor 48109, USA
    Postgrad Med 117:19-26. 2005
    ..In this article, the authors outline an approach to differential diagnosis of asthma and COPD that should result in better evaluation, therapy, and quality of life for these patients...
  6. ncbi request reprint The clinical course of patients with idiopathic pulmonary fibrosis
    Fernando J Martinez
    University of Michigan, Ann Arbor, Michigan 48109, USA
    Ann Intern Med 142:963-7. 2005
    ..Prospective data defining the clinical course in idiopathic pulmonary fibrosis (IPF) are sparse...
  7. pmc Course of FEV(1) after onset of bronchiolitis obliterans syndrome in lung transplant recipients
    Vibha N Lama
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 1500 East Medical Center Drive, 3916 Taubman Center, Ann Arbor, MI 48109 0360, USA
    Am J Respir Crit Care Med 175:1192-8. 2007
    ..Bronchiolitis obliterans syndrome (BOS), defined by loss of lung function, develops in the majority of lung transplant recipients. However, there is a paucity of information on the subsequent course of lung function in these patients...
  8. doi request reprint Clinical significance of radiologic characterizations in COPD
    MeiLan K Han
    University of Michigan Health System, Ann Arbor, Michigan 48109 5360, USA
    COPD 6:459-67. 2009
    ..Future research should clarify whether CT parameters complement BODE score in influencing survival...
  9. pmc Mesenchymal stromal cells in bronchoalveolar lavage as predictors of bronchiolitis obliterans syndrome
    Linda Badri
    1500 East Medical Center Drive, 3916 Taubman Center, Ann Arbor, MI 48109 0360, USA
    Am J Respir Crit Care Med 183:1062-70. 2011
    ....
  10. ncbi request reprint Idiopathic interstitial pneumonia: what is the effect of a multidisciplinary approach to diagnosis?
    Kevin R Flaherty
    Division of Pulmonary and Critical Care Medicine, Department of Radiology, University of Michigan Health System, 3916 Taubman Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0360, USA
    Am J Respir Crit Care Med 170:904-10. 2004
    ..We conclude that dynamic interactions between clinicians, radiologists, and pathologists improve interobserver agreement and diagnostic confidence...
  11. doi request reprint Cytotoxic potential of lung CD8(+) T cells increases with chronic obstructive pulmonary disease severity and with in vitro stimulation by IL-18 or IL-15
    Christine M Freeman
    Pulmonary and Critical Care Medicine Section, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI, 48105 2303, USA
    J Immunol 184:6504-13. 2010
    ..These findings suggest that the production of proinflammatory cytokines and cytotoxic molecules by lung-resident CD8(+) T cells contributes to COPD pathogenesis...
  12. pmc Longitudinal change in the BODE index predicts mortality in severe emphysema
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0360, USA
    Am J Respir Crit Care Med 178:491-9. 2008
    ..We hypothesized that decrease in a modified BODE (mBODE) would predict survival in National Emphysema Treatment Trial (NETT) patients...
  13. pmc Anxiety is associated with diminished exercise performance and quality of life in severe emphysema: a cross-sectional study
    Nicholas D Giardino
    Mental Health Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    Respir Res 11:29. 2010
    ..The purpose of this study is to determine whether there is an association between anxiety and functional measures, quality of life and dyspnea...
  14. pmc Physical activity, health status and risk of hospitalization in patients with severe chronic obstructive pulmonary disease
    Roberto P Benzo
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Respiration 80:10-8. 2010
    ..Self-reported daily physical activity and health status have been reported as predictors of a hospitalization in COPD but are not routinely assessed...
  15. pmc Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease
    Carlos H Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 3916 Taubman Center, Box 5360, 1500 E Medical Center Drive, Ann Arbor, MI 48109 5360, USA
    Thorax 67:399-406. 2012
    ..The authors hypothesised that QCT-defined emphysema and airway abnormalities relate to St George's Respiratory Questionnaire (SGRQ) and Body-Mass Index, Airflow Obstruction, Dyspnea and Exercise Capacity Index (BODE)...
  16. ncbi request reprint Surgical patient outcomes after the increased use of bilateral lung transplantation
    Andrew C Chang
    Section of Thoracic Surgery, University of Michigan Health System, Ann Arbor, Mich 48109, USA
    J Thorac Cardiovasc Surg 133:532-40. 2007
    ..Comparative results for single and sequential double lung transplantation performed at a single center are evaluated to determine whether such a policy improves patient outcome...
  17. pmc Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice
    Elizabeth M Pierce
    Associate Professor, Immunology Program, Department of Pathology, University of Michigan Medical School, Room 4057, BSRB, 109 Zina Pitcher Pl, Ann Arbor, MI 48109 0602, USA
    Am J Pathol 170:1152-64. 2007
    ....
  18. ncbi request reprint Prognostic implications of physiologic and radiographic changes in idiopathic interstitial pneumonia
    Kevin R Flaherty
    Departments of Radiology and Pathology, Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0360, USA
    Am J Respir Crit Care Med 168:543-8. 2003
    ..47; 95% confidence interval 1.29, 4.73; p = 0.006). We conclude that a 6-month change in forced vital capacity gives additional prognostic information to baseline features for patients with idiopathic interstitial pneumonia...
  19. pmc Increased cytokine response of rhinovirus-infected airway epithelial cells in chronic obstructive pulmonary disease
    Dina Schneider
    University of Michigan, Ann Arbor, MI 48109 5688, USA
    Am J Respir Crit Care Med 182:332-40. 2010
    ..Airway inflammation is a central feature of chronic obstructive pulmonary disease (COPD). COPD exacerbations are often triggered by rhinovirus (RV) infection...
  20. pmc Gender differences in symptoms and care delivery for chronic obstructive pulmonary disease
    Carlos H Martinez
    University of Michigan Health System, Ann Arbor, Michigan 48109 5360, USA
    J Womens Health (Larchmt) 21:1267-74. 2012
    ..Morbidity and mortality for women with chronic obstructive pulmonary disease (COPD) are increasing, and little is known about gender differences in perception of COPD care...
  21. pmc Relationship between lung function impairment and health-related quality of life in COPD and interstitial lung disease
    Cristine E Berry
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Chest 142:704-11. 2012
    ..However, different pathophysiologic mechanisms may influence how these distinct diseases affect HRQL, resulting in differing HRQL by pulmonary diagnosis among patients with similar severity of ventilatory impairment...
  22. pmc Variable prostaglandin E2 resistance in fibroblasts from patients with usual interstitial pneumonia
    Steven K Huang
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA
    Am J Respir Crit Care Med 177:66-74. 2008
    ..Although fibroblasts from patients with idiopathic pulmonary fibrosis are known to exhibit a defect in PGE2 synthesis, there is little information about their responsiveness to this lipid mediator...
  23. ncbi request reprint Enhanced monocyte chemoattractant protein-3/CC chemokine ligand-7 in usual interstitial pneumonia
    Esther S Choi
    Department of Pathology, University of Michigan Medical School, Rm 5216B, Med Sci I, 1301 Catherine Rd, Ann Arbor, MI 48109 0602, USA
    Am J Respir Crit Care Med 170:508-15. 2004
    ....
  24. ncbi request reprint Fibroblastic foci in usual interstitial pneumonia: idiopathic versus collagen vascular disease
    Kevin R Flaherty
    Department of Radiology, University of Michigan Health System, Ann Arbor, USA
    Am J Respir Crit Care Med 167:1410-5. 2003
    ..005). We conclude that patients with collagen vascular disease-associated usual interstitial pneumonia have fewer fibroblastic foci and improved survival...
  25. pmc Smoking decreases the response of human lung macrophages to double-stranded RNA by reducing TLR3 expression
    Jill C Todt
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health Care System, Ann Arbor, MI, 48109 2399, USA
    Respir Res 14:33. 2013
    ..We investigated whether smoking reduces expression by human lung macrophages (Mø) of receptors for viral nucleic acids and, if so, the effect on CXCL10 production...
  26. pmc Sex differences in severe pulmonary emphysema
    Fernando J Martinez
    University of Michigan, Division of Pulmonary and Critical Care Medicine, Ann Arbor, Michigan 48109 0360, USA
    Am J Respir Crit Care Med 176:243-52. 2007
    ..Limited data on sex differences in advanced COPD are available...
  27. doi request reprint Continuous oxygen use in nonhypoxemic emphysema patients identifies a high-risk subset of patients: retrospective analysis of the National Emphysema Treatment Trial
    Michael B Drummond
    Division of Pulmonary and Critical Care Medicine, The Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    Chest 134:497-506. 2008
    ..Little is known regarding the clinical characteristics and survival of nonhypoxemic emphysema patients using continuous oxygen. Analysis of data from the National Emphysema Treatment Trial (NETT) offers insight into this population...
  28. ncbi request reprint Prognostic value of desaturation during a 6-minute walk test in idiopathic interstitial pneumonia
    Vibha N Lama
    Department of Radiology, University of Michigan Health System, University of Michigan School of Public Health, Ann Arbor, MI 48109 0360, USA
    Am J Respir Crit Care Med 168:1084-90. 2003
    ..We conclude that knowledge of desaturation during a 6-minute walk test adds prognostic information for patients with usual interstitial pneumonia and nonspecific interstitial pneumonia...
  29. pmc Integrating health status and survival data: the palliative effect of lung volume reduction surgery
    Roberto Benzo
    Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota 55902, USA
    Am J Respir Crit Care Med 180:239-46. 2009
    ..This practice tends to inflate the apparent benefits of interventions with a high risk of mortality. Assessing a composite QoL-death outcome is a potential solution to this problem...
  30. pmc Optimizing the 6-min walk test as a measure of exercise capacity in COPD
    Divay Chandra
    Emphysema Research Center, Division of Pulmonary and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Chest 142:1545-52. 2012
    ..It is uncertain whether the effort and expense of performing a second walk for the 6-min walk test improves test performance. Hence, we attempted to quantify the improvement in 6-min walk distance if an additional walk were to be performed...
  31. ncbi request reprint Update in diffuse parenchymal lung diseases 2005
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0360, USA
    Am J Respir Crit Care Med 173:1066-71. 2006
  32. pmc Role of macrolide therapy in chronic obstructive pulmonary disease
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0360, USA
    Int J Chron Obstruct Pulmon Dis 3:331-50. 2008
    ..Additional, prospective, controlled data are required to define any potential treatment effect, the nature of this effect, and the role of bronchiectasis, baseline colonization, and other cormorbidities...
  33. pmc Gender influences Health-Related Quality of Life in IPF
    MeiLan K Han
    University of Michigan Health System, Pulmonary and Critical Care Medicine, Room 3916 Taubman Center, Ann Arbor, MI 48109 5360, USA
    Respir Med 104:724-30. 2010
    ..HRQL in IPF patients is impaired. Data from other respiratory diseases led us to hypothesize that significant gender differences in HRQL in IPF also exist...
  34. pmc Negative regulation of myofibroblast differentiation by PTEN (Phosphatase and Tensin Homolog Deleted on chromosome 10)
    Eric S White
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 West Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Am J Respir Crit Care Med 173:112-21. 2006
    ..Myofibroblasts are primary effector cells in idiopathic pulmonary fibrosis (IPF). Defining mechanisms of myofibroblast differentiation may be critical to the development of novel therapeutic agents...
  35. pmc Idiopathic pulmonary fibrosis: prognostic value of changes in physiology and six-minute-walk test
    Kevin R Flaherty
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Am J Respir Crit Care Med 174:803-9. 2006
    ..We hypothesized that changes in distance walked and quantity of desaturation during a six-minute-walk test (6MWT) would add prognostic information to changes in FVC or diffusing capacity for carbon monoxide...
  36. pmc Evidence for tissue-resident mesenchymal stem cells in human adult lung from studies of transplanted allografts
    Vibha N Lama
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, Michigan 48109 0360, USA
    J Clin Invest 117:989-96. 2007
    ....
  37. pmc Gender and chronic obstructive pulmonary disease: why it matters
    MeiLan K Han
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA
    Am J Respir Crit Care Med 176:1179-84. 2007
    ....
  38. ncbi request reprint Spirometry utilization for COPD: how do we measure up?
    MeiLan K Han
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0360, USA
    Chest 132:403-9. 2007
    ..COPD is a significant cause of morbidity and mortality. Guidelines recommend the confirmation of a COPD diagnosis with spirometry. Limited evidence exists, however, documenting the frequency of spirometry use in clinical practice...
  39. pmc Lung dendritic cell expression of maturation molecules increases with worsening chronic obstructive pulmonary disease
    Christine M Freeman
    Pulmonary and Critical Care Medicine Section, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    Am J Respir Crit Care Med 180:1179-88. 2009
    ..Dendritic cells (DCs) have not been well studied in chronic obstructive pulmonary disease (COPD), yet their integral role in activating and differentiating T cells makes them potential participants in COPD pathogenesis...
  40. doi request reprint Smoking-related interstitial lung disease: radiologic-clinical-pathologic correlation
    Anil K Attili
    Department of Radiology, Division of Cardiothoracic Radiology, University of Michigan Medical Center, Ann Arbor, MI 48109 2713, USA
    Radiographics 28:1383-96; discussion 1396-8. 2008
    ..Final diagnosis of an SR-ILD and identification of the specific entity can be achieved with certainty only after the pulmonologist, radiologist, and pathologist have reviewed all of the clinical, radiologic, and pathologic data...
  41. pmc Obligatory role for interleukin-13 in obstructive lesion development in airway allografts
    Vibha N Lama
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0644, USA
    Am J Pathol 169:47-60. 2006
    ..These human and murine data implicate IL-13 as a critical effector cytokine driving cellular recruitment and subsequent fibrosis in clinical and ex-perimental BO...
  42. pmc Predictors of mortality in patients with emphysema and severe airflow obstruction
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0360, and Section of Thoracic Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Respir Crit Care Med 173:1326-34. 2006
    ..Limited data exist describing risk factors for mortality in patients having predominantly emphysema...
  43. pmc Analysis of the lung microbiome in the "healthy" smoker and in COPD
    John R Erb-Downward
    University of Michigan, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e16384. 2011
    ..These studies are further demonstration of the pulmonary microbiome and highlight global and micro-anatomic changes in these bacterial communities in severe COPD patients...
  44. pmc Prognostic value of bronchiolitis obliterans syndrome stage 0-p in single-lung transplant recipients
    Vibha N Lama
    Division of Pulmonary and Critical Care Medicine, Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, 48109 0360, USA
    Am J Respir Crit Care Med 172:379-83. 2005
    ..Objective: The aim of this study was to define the predictive ability of BOS 0-p in single-lung transplantation...
  45. pmc Lung CD8+ T cells in COPD have increased expression of bacterial TLRs
    Christine M Freeman
    Research Service, Department of Veterans Affairs Healthcare System, Ann Arbor, MI 48105, USA
    Respir Res 14:13. 2013
    ..Toll-like receptors (TLRs) on T cells can modulate their responses, however, the extent and significance of TLR expression by lung T cells, NK cells, or NKT cells in chronic obstructive pulmonary disease (COPD) is unknown...
  46. pmc Sildenafil preserves exercise capacity in patients with idiopathic pulmonary fibrosis and right-sided ventricular dysfunction
    MeiLan K Han
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Chest 143:1699-708. 2013
    ..Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with pulmonary vasculopathy...
  47. doi request reprint Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A
    Shyamala Ganesan
    Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109 5688, USA
    Thorax 68:131-41. 2013
    ..Here, we examined the mechanisms underlying decreased FoxO3A activation and its modulation by quercetin in COPD human airway epithelial cells and in a COPD mouse model...
  48. pmc Periostin promotes fibrosis and predicts progression in patients with idiopathic pulmonary fibrosis
    Payal K Naik
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Am J Physiol Lung Cell Mol Physiol 303:L1046-56. 2012
    ..Thus periostin plays a vital role in late stages of pulmonary fibrosis and is a potential biomarker for disease progression and a target for therapeutic intervention...
  49. doi request reprint Idiopathic pulmonary fibrosis: clinically meaningful primary endpoints in phase 3 clinical trials
    Ganesh Raghu
    Division of Pulmonary and Critical Care Medicine, Campus Box 356175, University of Washington, Seattle, WA 98195, USA
    Am J Respir Crit Care Med 185:1044-8. 2012
    ..For patients with IPF, there are currently no validated surrogate endpoints...
  50. pmc Racial differences in quality of life in patients with COPD
    MeiLan K Han
    University of Michigan Health System, 3916 Taubman Center, 1500 E Medical Center Dr, Ann Arbor, MI 48109, USA
    Chest 140:1169-76. 2011
    ..We hypothesized that HRQL in COPD differs by race and sought to identify factors associated with those differences...
  51. pmc TLR9 differentiates rapidly from slowly progressing forms of idiopathic pulmonary fibrosis
    Glenda Trujillo
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 2200, USA
    Sci Transl Med 2:57ra82. 2010
    ..These data suggest that TLR9 may drive the pathogenesis of rapidly progressive idiopathic pulmonary fibrosis and may serve as a potential indicator for this subset of the disease...
  52. doi request reprint Treatment of idiopathic pulmonary fibrosis with ambrisentan: a parallel, randomized trial
    Ganesh Raghu
    Division of Pulmonary and Critical Care Medicine, University of Washington Medical Center, 1959 NE Pacific, Campus Box 356175, Seattle, WA 98195, USA
    Ann Intern Med 158:641-9. 2013
    ..Idiopathic pulmonary fibrosis (IPF) is characterized by formation and proliferation of fibroblast foci. Endothelin-1 induces lung fibroblast proliferation and contractile activity via the endothelin A (ETA) receptor...
  53. pmc Computed tomography-based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression
    Craig J Galban
    Department of Radiology, University of Michigan, Ann Arbor, MI, USA
    Nat Med 18:1711-5. 2012
    ..PRM's ability to differentiate between specific COPD phenotypes will allow for more accurate diagnosis of individual patients, complementing standard clinical techniques...
  54. pmc NADPH oxidase-4 mediates myofibroblast activation and fibrogenic responses to lung injury
    Louise Hecker
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Nat Med 15:1077-81. 2009
    ..These studies support a function for NOX4 in tissue fibrogenesis and provide proof of concept for therapeutic targeting of NOX-4 in recalcitrant fibrotic disorders...
  55. pmc An essential role for fibronectin extra type III domain A in pulmonary fibrosis
    Andres F Muro
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical School, 6301 MSRB III 0642, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0642, USA
    Am J Respir Crit Care Med 177:638-45. 2008
    ..Fibronectin containing extra type III domain A (EDA) is implicated in the regulation of wound healing. EDA-containing fibronectin is deposited during wound repair, and its presence precedes that of collagen...
  56. pmc Focusing on outcomes: making the most of COPD interventions
    Noreen M Clark
    Center for Managing Chronic Disease, University of Michigan, Ann Arbor, MI 48109 2029, USA
    Int J Chron Obstruct Pulmon Dis 4:61-77. 2009
    ....
  57. pmc A micro RNA processing defect in rapidly progressing idiopathic pulmonary fibrosis
    Sameer R Oak
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, United States of America
    PLoS ONE 6:e21253. 2011
    ..The aim of the present study was to ascertain whether differential miRNA expression might provide one explanation for rapidly versus slowly progressing forms of IPF...
  58. ncbi request reprint Hydrogen peroxide is a diffusible paracrine signal for the induction of epithelial cell death by activated myofibroblasts
    Meghna Waghray
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    FASEB J 19:854-6. 2005
    ..This novel mechanism for intercellular ROS signaling may be important in physiological/pathophysiological processes characterized by regenerating epithelial cells and activated myofibroblasts...
  59. doi request reprint Chronic obstructive pulmonary disease phenotypes: the future of COPD
    MeiLan K Han
    University of Michigan Pulmonary and Critical Care, 1500 E Medical Center Drive, 3916 Taubman, Ann Arbor, MI 48109, USA
    Am J Respir Crit Care Med 182:598-604. 2010
    ..We have much yet to learn, but establishing a common language for future research will facilitate our understanding and management of the complexity implicit to this disease...
  60. pmc Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes
    MeiLan K Han
    Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Radiology 261:274-82. 2011
    ....
  61. pmc The National Emphysema Treatment Trial (NETT) Part II: Lessons learned about lung volume reduction surgery
    Gerard J Criner
    Division of Pulmonary and Critical Care Medicine, Temple University, Philadelphia, Pennsylvania, USA
    Am J Respir Crit Care Med 184:881-93. 2011
    ..In this review, we summarize what we currently know about the role of LVRS in the treatment of severe emphysema as a result of insights gained from the NETT and provide a brief review of the newer techniques of lung volume reduction...
  62. ncbi request reprint Surgical therapy for chronic obstructive pulmonary disease
    Fernando J Martinez
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 3916 Taubman Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Semin Respir Crit Care Med 26:167-91. 2005
    ..In general, a COPD patient can be considered an appropriate candidate for transplantation when the FEV (1) is below 25% predicted and/or the paCO (2) is > or = 55 mm Hg...
  63. pmc Mesenchymal cell fate and phenotypes in the pathogenesis of emphysema
    Jeffrey C Horowitz
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 2319, USA
    COPD 6:201-10. 2009
    ....
  64. ncbi request reprint Thoracic lymph node enlargement in usual interstitial pneumonitis and nonspecific-interstitial pneumonitis: prevalence, correlation with disease activity and temporal evolution
    Anil K Attili
    Division of Thoracic Radiology, Department of Radiology, University of Michigan Medical School, Ann Arbor, MI 48109 0326, USA
    J Thorac Imaging 21:288-92. 2006
    ..To evaluate the prevalence of thoracic lymph node enlargement (LNE) in usual (UIP) and nonspecific (NSIP) interstitial pneumonitis, change in LNE over time, and if LNE is related to disease activity...
  65. doi request reprint Epigenetic mechanisms through which Toll-like receptor-9 drives idiopathic pulmonary fibrosis progression
    Cory M Hogaboam
    Department of Pathology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48103 2200, USA
    Proc Am Thorac Soc 9:172-6. 2012
    ....
  66. doi request reprint The impact of panic disorder on interoception and dyspnea reports in chronic obstructive pulmonary disease
    Nicholas D Giardino
    Mental Health Service, VA Ann Arbor Healthcare System, Ann Arbor, MI, USA
    Biol Psychol 84:142-6. 2010
    ..Emotional responses to dyspneic sensations may account for higher dyspnea ratings in patients with PD and COPD...
  67. pmc Idiopathic interstitial pneumonia: do community and academic physicians agree on diagnosis?
    Kevin R Flaherty
    University of Michigan Health System, Ann Arbor, MI 48109 0360, USA
    Am J Respir Crit Care Med 175:1054-60. 2007
    ..Treatment and prognoses of diffuse parenchymal lung diseases (DPLDs) varies by diagnosis. Obtaining a uniform diagnosis among observers is difficult...
  68. doi request reprint The National Emphysema Treatment Trial (NETT): Part I: Lessons learned about emphysema
    Gerard J Criner
    Division of Pulmonary and Critical Care Medicine, Temple University, School of Medicine, Philadelphia, PA 19140, USA
    Am J Respir Crit Care Med 184:763-70. 2011
    ..Herein, we provide a summary of the major NETT findings that provide insight into the evaluation and medical treatment of emphysema...
  69. doi request reprint Interleukin-17-mediated immunopathogenesis in experimental hypersensitivity pneumonitis
    Amrita D Joshi
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109 0602, USA
    Am J Respir Crit Care Med 179:705-16. 2009
    ..T cells play a critical role in the development of Saccharopolyspora rectivirgula-induced hypersensitivity pneumonitis (HP) but little is known about the role of IL-17A in this disease...
  70. ncbi request reprint International guidelines for the selection of lung transplant candidates: 2006 update--a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung Transplantation
    Jonathan B Orens
    Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Heart Lung Transplant 25:745-55. 2006
  71. pmc Pulmonary function testing in idiopathic interstitial pneumonias
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, Taubman Center 3916, 1500 East Medical Center Drive, Ann Arbor, MI 48109 0360, USA
    Proc Am Thorac Soc 3:315-21. 2006
    ..Finally, physiologic testing, especially spirometry and DLCO, have demonstrated value in monitoring response to therapy and identifying disease progression...
  72. pmc Human pulmonary fibroblasts exhibit altered interleukin-4 and interleukin-13 receptor subunit expression in idiopathic interstitial pneumonia
    Claudia Jakubzick
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0602, USA
    Am J Pathol 164:1989-2001. 2004
    ....
  73. doi request reprint Nonmedical therapy for chronic obstructive pulmonary disease
    Kevin M Chan
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109 0360, USA
    Proc Am Thorac Soc 6:137-45. 2009
    ..Over the past several decades, this has led to numerous nonpharmacologic approaches to ameliorate symptoms in these patients...
  74. pmc Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California, USA
    COPD 8:21-9. 2011
    ..Leukotrienes have been implicated in the pathogenesis of acute exacerbations of COPD, but leukotriene modifiers have not been studied as a possible therapy for exacerbations...
  75. pmc Modulation of prosurvival signaling in fibroblasts by a protein kinase inhibitor protects against fibrotic tissue injury
    Ragini Vittal
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, 6301 MSRB III, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Am J Pathol 166:367-75. 2005
    ..Thus, targeting of prosurvival signaling pathways in fibroblasts/myofibroblasts may provide a novel and effective strategy for anti-fibrotic therapy of treatment-unresponsive fibrotic disorders...
  76. pmc A plasminogen activator inhibitor-1 promoter polymorphism and idiopathic interstitial pneumonia
    Kevin K Kim
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, MI 48109 0642, USA
    Mol Med 9:52-6. 2003
    ..Patients with usual interstitial pneumonia did not show the same relationship with PAl-1 genotype...
  77. doi request reprint Accuracy of high-resolution CT in the diagnosis of diffuse lung disease: effect of predominance and distribution of findings
    Baskaran Sundaram
    Department of Radiology, University of Michigan Health System, Cardiovascular Center, Rm 5481, 1500 E Medical Center Dr, Ann Arbor, MI 48109 5868, USA
    AJR Am J Roentgenol 191:1032-9. 2008
    ..The purpose of this study was to determine whether the predominant findings at high-resolution CT influence the accuracy of diagnosis of diffuse lung disease...
  78. ncbi request reprint Pulmonary diseases and the heart
    MeiLan K Han
    University of Michigan Health System, Ann Arbor, MI, USA
    Circulation 116:2992-3005. 2007
    ....
  79. ncbi request reprint Mechanisms of pulmonary fibrosis
    Victor J Thannickal
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Annu Rev Med 55:395-417. 2004
    ....
  80. ncbi request reprint Nonspecific interstitial pneumonia
    Kevin R Flaherty
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0630, USA
    Semin Respir Crit Care Med 27:652-8. 2006
    ....
  81. ncbi request reprint Idiopathic interstitial pneumonias: usual interstitial pneumonia versus nonspecific interstitial pneumonia
    Fernando J Martinez
    University of Michigan Health System, 1500 East Medical Center Drive, 3916 Taubman Center, Ann Arbor, MI 48109 0360, USA
    Proc Am Thorac Soc 3:81-95. 2006
    ..The next few years will be an exciting time in the evaluation and treatment of DPLDs as increasing clinically relevant biological information is translated to novel diagnostic and therapeutic approaches...
  82. ncbi request reprint Resting and exercise physiology in interstitial lung diseases
    Vibha N Lama
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, 1500 East Medical Center Drive, 3916 Taubman Center, Ann Arbor, MI 48109 0360, USA
    Clin Chest Med 25:435-53, v. 2004
    ..Although their role in the differential diagnosis of the various ILDs is limited, physiologic measurements are pivotal studies providing clues regarding disease severity, prognosis,and response to therapy...
  83. ncbi request reprint Patient selection for lung volume reduction surgery
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 1500 E Medical Center Drive, 3916 Taubman Center, Ann Arbor, MI 48109 0360, USA
    Chest Surg Clin N Am 13:669-85. 2003
    ..Additional data collection will better define the long-term benefits of such surgical intervention in patients who have COPD...
  84. ncbi request reprint Role of infection and antimicrobial therapy in acute exacerbations of chronic obstructive pulmonary disease
    Fernando J Martinez
    The University of Michigan Health System, 1500 East Medical Center Drive, 3916 Taubman Center, Box 0360, Ann Arbor, MI 48109, USA
    Expert Rev Anti Infect Ther 4:101-24. 2006
    ..In the future, preventing exacerbations will likely become increasingly accepted as an additional therapeutic goal in chronic obstructive pulmonary disease patients...
  85. ncbi request reprint Idiopathic pulmonary fibrosis: emerging concepts on pharmacotherapy
    Victor J Thannickal
    Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, 6301 MSRB III, 1150 W Medical Center Drive, Ann Arbor, MI 48109, USA
    Expert Opin Pharmacother 5:1671-86. 2004
    ..Emerging 'antifibrotic' drugs and strategies for UIP/IPF are discussed. The importance of accurately phenotyping a highly heterogeneous disease process that may require individualised and 'combined' therapies is emphasised...
  86. ncbi request reprint Cigarette smoking in interstitial lung disease: concepts for the internist
    Kevin R Flaherty
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, 1500 East Medical Center Drive, 3916 Taubman Center, Ann Arbor, MI 48109 0360, USA
    Med Clin North Am 88:1643-53, xiii. 2004
    ..The exact role of cigarette smoking in the development of interstitial lung diseases is still being defined; the relatively low prevalence of interstitial lung disease makes epidemiologic studies difficult...
  87. ncbi request reprint Clinical implications of macrolide therapy in chronic sinopulmonary diseases
    Fernando J Martinez
    Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, Michigan, USA
    Curr Pharm Des 10:3095-110. 2004
    ..When available, the data addressing the presumed mechanisms underlying clinical benefits are presented...
  88. pmc Development and initial validation of a self-scored COPD Population Screener Questionnaire (COPD-PS)
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, Ann Arbor, MI 48109, USA
    COPD 5:85-95. 2008
    ..8% and negative predictive value of 86.4%. The COPD-PS accurately classified physician-reported COPD (AUC = 0.89). The COPD-PS is a brief, accurate questionnaire that can identify individuals likely to have COPD...
  89. ncbi request reprint Monotherapy versus dual therapy for community-acquired pneumonia in hospitalized patients
    Fernando J Martinez
    Division of Pulmonary and Critical Care, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0360, USA
    Clin Infect Dis 38:S328-40. 2004
    ....
  90. pmc Pathogen-directed therapy in acute exacerbations of chronic obstructive pulmonary disease
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 1500 East Medical Center Drive, SPC 5360, Ann Arbor, MI 48109 5360, USA
    Proc Am Thorac Soc 4:647-58. 2007
    ..As such, the future will likely include aggressive diagnostic algorithms based on the combination of clinical syndromes and rapid laboratory modalities to identify specific causative bacteria or viruses...
  91. ncbi request reprint Lessons from the national emphysema treatment trial
    Andrew C Chang
    Department of Surgery, Section of Thoracic Surgery, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    Semin Thorac Cardiovasc Surg 19:172-80. 2007
    ..The purpose of this article is to review the contributions of the NETT to the management of chronic obstructive pulmonary disease...
  92. ncbi request reprint Clinical relevance of macrolide-resistant Streptococcus pneumoniae for community-acquired pneumonia
    Joseph P Lynch III
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Health System, Ann Arbor, MI, 48109, USA
    Clin Infect Dis 34:S27-46. 2002
    ..In this article, we discuss the prevalence of macrolide resistance among S. pneumoniae, risk factors and mechanisms responsible for resistance, therapeutic strategies, and implications for the future...
  93. ncbi request reprint Acute bronchitis: state of the art diagnosis and therapy
    Fernando J Martinez
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Mich, USA
    Compr Ther 30:55-69. 2004
    ..Simple bronchitis is best treated symptomatically while an exacerbation of chronic bronchitis can be treated with antibiotics. Broad spectrum antibiotics are appropriate in selected patients...
  94. ncbi request reprint Efficacy and safety of 3-day azithromycin versus 5-day moxifloxacin for the treatment of acute bacterial exacerbations of chronic bronchitis
    Marcus Zervos
    Henry Ford Hospital, Detroit, MI 48202, USA
    Int J Antimicrob Agents 29:56-61. 2007
    ..Compliance with both regimens was >90%. Three-day azithromycin and 5-day moxifloxacin demonstrate comparable efficacy and safety for the treatment of AECB in outpatients...
  95. ncbi request reprint Sex, depression, and risk of hospitalization and mortality in chronic obstructive pulmonary disease
    Vincent S Fan
    Health Services Research and Development Center of Excellence, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108 1597, USA
    Arch Intern Med 167:2345-53. 2007
    ....
  96. pmc Relationship between pathologic characteristics of peripheral airways and outcome after lung volume reduction surgery in severe chronic obstructive pulmonary disease
    Frank C Sciurba
    Division of Pulmonary and Critical Care Medicine, Emphysema Research Center, University of Pittsburgh, Suite 1211, 3471 Fifth Avenue, PA 15213, USA
    Proc Am Thorac Soc 3:533-4. 2006
  97. doi request reprint Idiopathic nonspecific interstitial pneumonia: report of an American Thoracic Society project
    William D Travis
    Attending Thoracic Pathologist, Department of Pathology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA
    Am J Respir Crit Care Med 177:1338-47. 2008
    ..Concern was expressed that NSIP was a "wastebasket" category, difficult to distinguish from other idiopathic interstitial pneumonias...
  98. pmc Genetic association analysis of functional impairment in chronic obstructive pulmonary disease
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    Am J Respir Crit Care Med 173:977-84. 2006
    ..This variation may reflect different COPD subtypes, which may have different genetic predispositions...
  99. pmc Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathology
    James C Hogg
    University of British Columbia iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
    Am J Respir Crit Care Med 176:454-9. 2007
    ..COPD is associated with reduced life expectancy...
  100. ncbi request reprint Exacerbations of chronic obstructive pulmonary disease
    Antonio Anzueto
    South Texas Veterans Health Care System, Audie L Murphy Division, University of Texas Health Science Center, 7400 Merton Minter Boulevard, San Antonio, TX 78229, USA
    Proc Am Thorac Soc 4:554-64. 2007
    ..We summarize the current literature, with special emphasis on the assessment of the long-term impact of this condition...
  101. ncbi request reprint The value of early diagnosis for effective management of chronic obstructive pulmonary disease
    Dennis E Doherty
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Kentucky, Veterans Administration Medical Center, Lexington, KY, USA
    J Fam Pract 56:S1-24. 2007