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| F D MartinezSummaryAffiliation: University of Arizona Country: USA Publications
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Publications
The origins of asthma and chronic obstructive pulmonary disease in early lifeFernando D Martinez
Arizona Respiratory Center, University of Arizona College of Medicine, 1501 N Campbell Avenue, PO Box 245030, Tucson, AZ 85724 5030, USA
Proc Am Thorac Soc 6:272-7. 2009..Novel strategies for primary prevention of chronic respiratory diseases will be based on the identification of the genetic and environmental factors that interactively cause these disruptions...
New insights into the natural history of asthma: primary prevention on the horizonFernando D Martinez
Arizona Respiratory Center and BIO5 Institute, University of Arizona, Tucson, Ariz 85712, USA
J Allergy Clin Immunol 128:939-45. 2011..It is thus plausible to hypothesize that primary prevention of asthma could be attained through surrogate therapeutic interventions that activate similar mechanisms in young children at high risk for asthma...- Epidemiology of the origins of airflow limitation in asthmaStefano Guerra
Arizona Respiratory Center, University of Arizona, Tucson, Arizona 85724 5030, USA
Proc Am Thorac Soc 6:707-11. 2009.... - The connection between early life wheezing and subsequent asthma: The viral marchF D Martinez
The Arizona Respiratory Center and the BIO5 Institute, The University of Arizona, United States
Allergol Immunopathol (Madr) 37:249-51. 2009..7) The purpose of this brief comment is to review the evidence which suggests that susceptibility to infection with rhinovirus may be a critical additional factor explaining this connection... 
Serious adverse events and death associated with treatment using long-acting beta-agonistsFernando D Martinez
Arizona Respiratory Center, University of Arizona College of Medicine, Tucson, AZ
Clin Rev Allergy Immunol 31:269-78. 2006..Until the biological mechanisms involved are better understood, efforts should be made to confine the use of LABAs to those patients who really need them...- Asthma treatment and asthma prevention: a tale of 2 parallel pathwaysFernando D Martinez
Arizona Respiratory Center, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
J Allergy Clin Immunol 119:30-3. 2007..quot;.. - Managing childhood asthma: challenge of preventing exacerbationsFernando D Martinez
Department of Pediatrics and Arizona Respiratory Center, University of Arizona, Tucson, Arizona, USA
Pediatrics 123:S146-50. 2009..This strategy is currently being tested in a large clinical trial involving children with mild persistent asthma... - Genes, environments, development and asthma: a reappraisalF D Martinez
Arizona Respiratory Center, University of Arizona, 1501 N Campbell Avenue, Tucson, AZ, USA
Eur Respir J 29:179-84. 2007..Elucidating these complex interactions will allow us to understand better the heterogeneity of the disease and thus to develop therapeutic tools tailored to the specific form of the disease in each patient... - CD14, endotoxin, and asthma risk: actions and interactionsFernando D Martinez
Arizona Respiratory Center, University of Arizona, 1501 N Campbell Avenue, Ste 2349, P O Box 245030, Tucson, AZ 85724, USA
Proc Am Thorac Soc 4:221-5. 2007..These results suggest that the often encountered, limited replicability of genetic associations may, at least in part, be due to complex interactions between genes and environment in determining asthma-related outcomes... - Gene-environment interactions in asthma: with apologies to William of OckhamFernando D Martinez
Arizona Respiratory Center, University of Arizona, Tucson, Arizona 85724, USA
Proc Am Thorac Soc 4:26-31. 2007..More likely, the most important gene variants for asthma are polymorphisms that exert their influence on the network system controlling biological responses to asthma-related exposures... - Inhaled corticosteroids and asthma preventionFernando D Martinez
Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
Lancet 368:708-10. 2006 - Gene-environment interactions in asthma and allergies: a new paradigm to understand disease causationFernando D Martinez
Arizona Respiratory Center, College of Medicine, The University of Arizona, 1501 N Campbell Avenue, 2349, Tucson, AZ 85724 5030, USA
Immunol Allergy Clin North Am 25:709-21. 2005..Discrepancies between well-designed genetic studies of asthma and allergies, therefore, may be suggesting something fundamental about how these diseases develop and how it will be possible to abolish them in the future... - Use of beclomethasone dipropionate as rescue treatment for children with mild persistent asthma (TREXA): a randomised, double-blind, placebo-controlled trialFernando D Martinez
Arizona Respiratory Center, College of Medicine, University of Arizona, Tucson, AZ, USA
Lancet 377:650-7. 2011..We assessed the effectiveness of an inhaled corticosteroid (beclomethasone dipropionate) used as rescue treatment... - Heterogeneity of the association between lower respiratory illness in infancy and subsequent asthmaFernando D Martinez
Swift McNear Professor of Pediatrics, Director, Arizona Respiratory Center, The University of Arizona, 1501 N Campbell Avenue, Suite 2349 Tucson, AZ 85724 5030, USA
Proc Am Thorac Soc 2:157-61. 2005..Future preventive and therapeutic strategies will need to address the specific mechanisms that explain this association in different groups of subjects... - Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school yearsJ A Castro-Rodriguez
Respiratory Sciences Center, University of Arizona, College of Medicine, Tucson, AZ 85724, USA
Am J Respir Crit Care Med 163:1344-9. 2001..In females, becoming overweight or obese between 6 and 11 yr of age increases the risk of developing new asthma symptoms and increased bronchial responsiveness during the early adolescent period... - Relation of two different subtypes of croup before age three to wheezing, atopy, and pulmonary function during childhood: a prospective studyJ A Castro-Rodriguez
Respiratory Sciences Center, University of Arizona, College of Medicine, Tucson, Arizona, USA
Pediatrics 107:512-8. 2001..The objective of this study was to determine the long-term outcome of croup (as diagnosed by a physician) in early life... - Factors influencing the relation of infant feeding to asthma and recurrent wheeze in childhoodA L Wright
Respiratory Sciences Center, Arizona Health Sciences Center and Department of Pediatrics and Steele Memorial Children s Research Center, University of Arizona, Tucson, Arizona, USA
Thorax 56:192-7. 2001..The relationship between infant feeding and childhood asthma is controversial. This study tested the hypothesis that the relation between breast feeding and childhood asthma is altered by the presence of maternal asthma... - Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezingF D Martinez
Respiratory Sciences Center, The University of Arizona College of Medicine, Tucson, Arizona 85724, USA
J Clin Invest 100:3184-8. 1997..No association was found between the beta2AR-27 polymorphism and response to albuterol. These results may explain some of the variability in response to therapeutic doses of albuterol in children... - Relation between infantile colic and asthma/atopy: a prospective study in an unselected populationJ A Castro-Rodriguez
Arizona Respiratory Center, University of Arizona, College of Medicine, Tucson, Arizona, USA
Pediatrics 108:878-82. 2001..To assess whether children with history of infantile colic may be at increased risk of subsequently developing asthma and/or atopy... - Polymorphisms in the CD14 gene associated with pulmonary function in farmersTricia D LeVan
Arizona Respiratory Center and Departments of Internal Medicine and Pediatrics, College of Medicine, University of Arizona, Tucson, Arizona, USA
Am J Respir Crit Care Med 171:773-9. 2005..Farmers experience airway obstruction, which may be attributable in part to endotoxin inhalation. CD14 is a receptor for endotoxin... - Dog exposure in infancy decreases the subsequent risk of frequent wheeze but not of atopyS T Remes
Respiratory Sciences Center, Arizona Health Sciences Center, University of Arizona, Tucson 85724, USA
J Allergy Clin Immunol 108:509-15. 2001..Nevertheless, early pet exposure does not seem to significantly influence the development of allergic sensitization... - Familial correlation and segregation analysis of forced expiratory volume in one second (FEV1), with and without smoking adjustments, in a Tucson populationM Kurzius-Spencer
University of Arizona, Respiratory Sciences Center, Tucson, USA
Ann Hum Biol 28:222-34. 2001..However, the influence of cigarette smoking on familial aggregation of FEV1 has been difficult to assess in these studies... - Two subphenotypes of childhood asthma that differ in maternal and paternal influences on asthma riskM Halonen
Respiratory Sciences Center and Departments of Pharmacology and Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona, USA
Am J Respir Crit Care Med 160:564-70. 1999..Thus, dividing asthma in children at age 6 into Alternaria-positive and Alternaria-negative groups identifies subphenotypes that are further distinguished by differences in phenotypic markers and parental influences... - Opposite effects of CD 14/-260 on serum IgE levels in children raised in different environmentsWaltraud Eder
Innate Immunity Program for Genomic Applications, Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA
J Allergy Clin Immunol 116:601-7. 2005..Most complex diseases are the result of interactions between polymorphisms in the genome and environmental exposures... - Chronic bronchitis before age 50 years predicts incident airflow limitation and mortality riskS Guerra
Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724 5030, USA
Thorax 64:894-900. 2009.... - Decreased activation of inflammatory networks during acute asthma exacerbations is associated with chronic airflow obstructionA Bosco
Arizona Respiratory Center, College of Medicine, University of Arizona, Tucson, Arizona, USA
Mucosal Immunol 3:399-409. 2010..Our findings show that decreased activation of Th1-like/cytotoxic and interferon pathways is a hallmark of acute exacerbation responses in asthmatic children with evidence of chronic airways obstruction... - Familial aggregation and segregation analysis of eosinophil levelsC J Holberg
Respiratory Sciences Center, Department of Pediatrics, University of Arizona Health Sciences Center, Tucson, Arizona
Am J Respir Crit Care Med 160:1604-10. 1999..Holberg CJ, Halonen M, Wright AL, Martinez FD. Familial aggregation and segregation analysis of eosinophil levels... - Reduced interferon gamma production and soluble CD14 levels in early life predict recurrent wheezing by 1 year of ageStefano Guerra
Arizona Respiratory Center, College of Medicine, University of Arizona, Tucson, Arizona 85724-5030, USA
Am J Respir Crit Care Med 169:70-6. 2004..031). Our findings from a longitudinal cohort suggest that impaired IFNgamma production at 3 months and reduced plasma-sCD14 levels at birth significantly increase the risk of developing recurrent wheezing in the first year of life... - Association between CD14 polymorphisms and serum soluble CD14 levels: effect of atopy and endotoxin inhalationTricia D LeVan
Arizona Respiratory Center, University of Arizona College of Medicine, Tucson, Arizona, USA
J Allergy Clin Immunol 121:434-440.e1. 2008..A prerequisite for activation of the innate immune response by endotoxin is its binding to CD14... - Toll-like receptor 2 as a major gene for asthma in children of European farmersWaltraud Eder
Arizona Respiratory Center, University of Arizona, Tucson 85724, USA
J Allergy Clin Immunol 113:482-8. 2004..The toll-like receptors (TLRs) represent an evolutionarily conserved family of innate immunity receptors with microbial molecules as ligands... - The relationship between parental and children's serum IgE and asthmaB Burrows
Respiratory Sciences Center, University of Arizona College of Medicine, Tucson 85724, USA
Am J Respir Crit Care Med 152:1497-500. 1995..We speculate that the inflammation in the airways of asthmatic patients itself tends to increase the serum IgE level, possibly secondary to mediators that it generates... - Parental asthma as a risk factor for the development of early skin test sensitization in childrenElena Crestani
Arizona Respiratory Center, Health Sciences Center, Tucson, Ariz, USA
J Allergy Clin Immunol 113:284-90. 2004..The strong association between allergic sensitization and asthma is at least in part explained by an increased susceptibility to allergen sensitization in subjects predisposed to asthma... - Safety of long-acting beta-agonists--an urgent need to clear the airFernando D Martinez
Arizona Respiratory Center, University of Arizona College of Medicine, Tucson, USA
N Engl J Med 353:2637-9. 2005 - The relation of body mass index to asthma, chronic bronchitis, and emphysemaStefano Guerra
Arizona Respiratory Center, College of Medicine, University of Arizona, 1501 N. Campbell Avenue, Tucson, AZ 85724-5030, USA
Chest 122:1256-63. 2002..Preobese and obese women are at increased risk of acquiring asthma. This relation, particularly if it is causal, has potentially relevant public health implications... - Rhinitis as an independent risk factor for adult-onset asthmaStefano Guerra
Arizona Respiratory Center, University of Arizona, College of Medicine, Tucson 85724-5030, USA
J Allergy Clin Immunol 109:419-25. 2002..CONCLUSION: We conclude that rhinitis is a significant risk factor for adult-onset asthma in both atopic and nonatopic subjects. The nature of the association between rhinitis and asthma is open to interpretation... - Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort studyDebra A Stern
Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA
Lancet 372:1058-64. 2008..Incidence of asthma increases during early adulthood. We aimed to estimate the contributions of sex and early life factors to asthma diagnosed in young adults... - Prenatal factors associated with the development of eczema in the first year of lifeMargaret Kurzius-Spencer
Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724-5030, USA
Pediatr Allergy Immunol 16:19-26. 2005..32, CI 0.16-0.63, p <0.001). Our findings from this cohort study suggest that in utero factors, including maternal IgE, colds, and eczema, may influence the risk of infant eczema... - A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activityT D LeVan
Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
J Immunol 167:5838-44. 2001..Variation in a key gene of innate immunity may be important for the pathogenesis of allergy and inflammatory disease through gene-by-gene and/or gene-by-environment interactions... - Links between pediatric and adult asthmaF D Martinez
Respiratory Sciences Center, The University of Arizona, Tucson, Ariz, USA
J Allergy Clin Immunol 107:S449-55. 2001..Congenital and acquired deficits in lung function, however, may lead to recurrence of these symptoms during adult life and after long periods of remission, especially among active smokers... - Long-term inhaled corticosteroids in preschool children at high risk for asthmaTheresa W Guilbert
Division of Pediatric Pulmonary Medicine, Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
N Engl J Med 354:1985-97. 2006..It is unknown whether inhaled corticosteroids can modify the subsequent development of asthma in preschool children at high risk for asthma... - Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescenceWayne J Morgan
Arizona Respiratory Center, P.O. Box 245030, Tucson, Arizona 85724, USA
Am J Respir Crit Care Med 172:1253-8. 2005..CONCLUSION: Patterns of wheezing prevalence and levels of lung function are established by age 6 yr and do not appear to change significantly by age 16 yr in children who start having asthma-like symptoms during the preschool years... - Is there a common cold constitution?Thomas M Ball
Department of Pediatrics and the Steele Memorial Children s Research Center, University of Arizona College of Medicine, Tucson 85724 5073, USA
Ambul Pediatr 2:261-7. 2002..Constitutional factors might play a role in the susceptibility to clinical illness during the common cold. This study seeks to determine if the likelihood of developing frequent common colds persists during childhood... - Morbidity and mortality associated with the restrictive spirometric pattern: a longitudinal studyStefano Guerra
Arizona Respiratory Center, University of Arizona, Tucson, Arizona 85724 5030, USA
Thorax 65:499-504. 2010..This study was undertaken to determine demographic, clinical and mortality profiles of subjects with either a recurrent or an inconsistent restrictive spirometric pattern assessed prospectively... - Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5 q 33Penelope E Graves
Arizona Respiratory Center, University of Arizona, Tuscon, AZ 85724 5030, USA
J Allergy Clin Immunol 116:650-6. 2005.... - Respiratory syncytial virus bronchiolitis and the pathogenesis of childhood asthmaFernando D Martinez
Arizona Respiratory Center, University of Arizona College of Medicine, PO Box 245030, 1501 N Campbell Avenue, Room 2349, Tucson, AZ 85764, USA
Pediatr Infect Dis J 22:S76-82. 2003..It is likely, however, that strategies for the prevention of RSV infection may play a role in the prevention of the subsequent development of persistent wheezing and asthma-like symptoms in childhood... - Factors influencing gender differences in the diagnosis and treatment of asthma in childhood: the Tucson Children's Respiratory StudyAnne L Wright
Arizona Respiratory Center, Arizona Health Sciences Center, Tucson, Arizona 85724, USA
Pediatr Pulmonol 41:318-25. 2006..8 vs. 1.6 years, P < 0.005). These findings indicate that gender differences in the diagnosis and treatment of asthma cannot be explained completely by differences in symptom prevalence and frequency... - Relation of beta2-adrenoceptor polymorphisms at codons 16 and 27 to persistence of asthma symptoms after the onset of pubertyStefano Guerra
Arizona Respiratory Center, University of Arizona, 1501 N Campbell Ave, PO Box 245030, Tucson, AZ 85724 5030, USA
Chest 128:609-17. 2005..It has long been recognized that many children with asthma outgrow the disease after the onset of puberty, but little is known about genetic factors influencing this outcome... - The relation of rhinitis to recurrent cough and wheezing: a longitudinal studyDuane L Sherrill
Mel and Enid Zuckerman College of Public Health, University of Arizona, Arizona, USA
Respir Med 99:1377-85. 2005..Recurrent cough can be a clinical manifestation of rhinitis. However, it remains unclear if the association between rhinitis and recurrent cough among children is independent of asthma... - Asthma genetics: from linear to multifactorial approachesStefano Guerra
Arizona Respiratory Center, University of Arizona, Tucson, Arizona 85724, USA
Annu Rev Med 59:327-41. 2008.... - Influence of attendance at day care on the common cold from birth through 13 years of ageThomas M Ball
Department of Pediatrics, University of Arizona College of Medicine, 1501 N Campbell Ave, PO Box 245073, Tucson, AZ 85724 5073, USA
Arch Pediatr Adolesc Med 156:121-6. 2002..To describe trends in the occurrence of the common cold during the first 13 years of life among children who attended different childcare settings early in life... - Development of wheezing disorders and asthma in preschool childrenFernando D Martinez
University of Arizona, Tucson, Arizona, USA
Pediatrics 109:362-7. 2002..Defining which children are at risk for persistent asthma could allow for better management and, potentially, for reduced morbidity and mortality... - Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthmaTheresa W Guilbert
Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
J Allergy Clin Immunol 114:1282-7. 2004.... - The course of persistent airflow limitation in subjects with and without asthmaStefano Guerra
Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA
Respir Med 102:1473-82. 2008..We sought to compare the natural course of lung function associated with persistent airflow limitation in subjects with and without asthma from early to late adult life... - Environmental determinants of and impact on childhood asthma by the bacterial community in household dustRaina M Maier
Department of Soil, Water and Environmental Science, University of Arizona, 429 Shantz Building 38, Tucson, AZ 85721, USA
Appl Environ Microbiol 76:2663-7. 2010..0103) and specific IgE (P = 0.0184). Our findings suggest that specific bacterial populations within the community are associated with either risk or protection from asthma... - The Prevention of Early Asthma in Kids study: design, rationale and methods for the Childhood Asthma Research and Education networkTheresa W Guilbert
Division of Pediatric Pulmonary Medicine, Arizona Respiratory Center, University of Arizona, 1501 N Campbell Avenue, PO Box 245073, Tucson, AZ 85724, USA
Control Clin Trials 25:286-310. 2004..These measures were chosen to reflect the progression of the disease from intermittent wheezing to persistent asthma and measurement of the extent of airflow limitation and airway reactivity... - Differences in proliferation of the hematopoietic cell line TF-1 and cytokine production by peripheral blood leukocytes induced by 2 naturally occurring forms of human IL-3A Schweiger
Respiratory Sciences Center, The University of Arizona, Tucson, USA
J Allergy Clin Immunol 107:505-10. 2001.... - Association between exposure to farming, allergies and genetic variation in CARD4/NOD1W Eder
Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA, and Dr von Hauner Children s Hospital, University of Munich, Germany
Allergy 61:1117-24. 2006..We therefore aimed to explore whether the previously observed inverse association between exposure to microbial products and asthma and allergies in childhood is modified by genetic variation in CARD4... - Familial correlation in the decline of forced expiratory volume in one secondM Kurzius-Spencer
Respiratory Sciences Center, University of Arizona Health Sciences Center, Tucson, Arizona 85724, USA
Am J Respir Crit Care Med 164:1261-5. 2001..High sibling correlation in the absence of parent-offspring correlation is compatible with a recessive model of inheritance... - Dynamic changes in sensitization to specific aeroallergens in children raised in a desert environmentD A Stern
The Arizona Respiratory Center and The Departments of Pharmacology and Pediatrics, The University of Arizona HSC, Tucson, AZ 85724, USA
Clin Exp Allergy 34:1563-669. 2004..CONCLUSION: This study shows that sensitization to individual aeroallergens in childhood is dynamic and indicates the limitation of single point assessment of skin test reactivity... - The differential effect of genetic variation on soluble CD14 levels in human plasma and milkStefano Guerra
Arizona Respiratory Center, College of Medicine, University of Arizona, Tuscon, AZ 85724 5030, USA
Am J Reprod Immunol 52:204-11. 2004..The protein CD14 is a pattern recognition receptor for bacterial lipopolysaccharide (LPS). Whether genetic variation has the same influence on soluble CD14 (sCD14) levels in human plasma and milk remains to be determined... - Effect of breastfeeding on lung function in childhood and modulation by maternal asthma and atopyTheresa W Guilbert
Arizona Respiratory Center, Department of Pediatrics, University of Arizona, Tucson, Arizona, USA
Am J Respir Crit Care Med 176:843-8. 2007..The protective effect of breastfeeding on early respiratory infections is well established, but its relationship to the development of subsequent asthma remains controversial... - What have we learned from the Tucson Children's Respiratory Study?Fernando D Martinez
Arizona Respiratory Center, The University of Arizona, Tucson, AZ, USA
Paediatr Respir Rev 3:193-7. 2002..Understanding the different asthma phenotypes of childhood will provide new clues for strategies for the primary prevention of the disease... - Persistence of asthma symptoms during adolescence: role of obesity and age at the onset of pubertyStefano Guerra
Arizona Respiratory Center, University of Arizona, 1501 North Campbell Avenue, P.O. Box 245030, Tucson, AZ 85724-5030, USA
Am J Respir Crit Care Med 170:78-85. 2004..Our findings from a population-based longitudinal cohort challenge the commonly held view that asthma usually remits during adolescence... - The coming-of-age of the hygiene hypothesisF D Martinez
The Respiratory Sciences Center, University of Arizona, Tucson, Arizona, USA
Respir Res 2:129-32. 2001..The latter interact with a sensitive and complex receptor system, and genetic variations in this receptor system may be an important determinant of inherited susceptibility to asthma and allergies... - CD14: an example of gene by environment interaction in allergic diseaseM Baldini
Arizona Respiratory Center, University of Arizona, Tucson, AZ, USA
Allergy 57:188-92. 2002 - Differential control of eosinophil survival by glucocorticoidsJ W Bloom
Arizona Respiratory Center and the Department of Pharmacology at the University of Arizona, Tucson, AZ 85724, USA
Apoptosis 9:97-104. 2004..It is tempting to speculate that the observed glucocorticoid enhancement of eosinophil survival in the presence of elevated concentrations of IL-5 could be a mechanism that contributes to glucocorticoid resistance in asthma... - Gene-environment interaction in complex diseases: asthma as an illustrative caseFernando D Martinez
Arizona Respiratory Center, University of Arizona, 1501 N Cambpbell Ave, Rm 2349, PO Box 245030, Tucson, AZ 85724 5030, USA
Novartis Found Symp 293:184-92; discussion 192-7. 2008..A better understanding of the genetics of asthma is thus inseparable from a better understanding of the mechanisms by which environmental factors increase the risk for asthma or protect against it... - Automated high-throughput sex-typing assayLizhi Yu
Arizona Respiratory Center, Tucson, Arizona 85641, USA
Biotechniques 37:662-4. 2004 - Poor airway function in early infancy and lung function by age 22 years: a non-selective longitudinal cohort studyDebra A Stern
Arizona Respiratory Center, University of Arizona, Tucson, Arizona, USA
Lancet 370:758-64. 2007..We aimed to investigate whether lung function in early adulthood is, in turn, affected by airway function measured shortly after birth... - Trends in asthma prevalence, admission rates, and asthma deathsFernando D Martinez
Arizona Respiratory Center, 1501 N Campbell Avenue, Tucson AZ 85724 5030, USA
Respir Care 53:561-5; discussion 565-7. 2008..A better understanding of what determines the stable asthma death rate is urgently needed, especially since inhaled corticosteroids have been shown to prevent asthma deaths in persons who take them regularly... - Effects of parental smoking on interferon gamma production in childrenGina Tebow
Arizona Respiratory Center, University of Arizona, 1501 N Campbell Ave, PO Box 245030, Tucson, AZ 85724 5030, USA
Pediatrics 121:e1563-9. 2008..In a population-based birth cohort, we sought to determine the relation of parental smoking, as assessed prospectively since pregnancy, to the child's interferon gamma and interleukin 4 production at 11 years of age... - Low IFN-gamma production in the first year of life as a predictor of wheeze during childhoodDebra A Stern
The Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
J Allergy Clin Immunol 120:835-41. 2007..Diminished cytokine production in infancy has been associated with an increased risk for allergen sensitization and early-life wheeze... - Drug development strategies for asthma: in search of a new paradigmPatrick G Holt
Telethon Institute for Child Health Research, and Centre for Child Health Research, The University of Western Australia, Perth, Western Australia
Nat Immunol 5:695-8. 2004..What is needed is informed debate on the risks versus potential benefits of this approach... - TOLL-like receptor 10 genetic variation is associated with asthma in two independent samplesRoss Lazarus
Channing Laboratory, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 170:594-600. 2004..026 for c.+1031G>A). Consistent association in two independent samples and association with an intermediate phenotype provides strong support for TLR10 genetic variation contributing to asthma risk... - Asthma phenotypes in childhood: lessons from an epidemiological approachRenato T Stein
Pediatric Pulmonary Section, Department of Pediatrics, , Porto Alegre, Brazil
Paediatr Respir Rev 5:155-61. 2004..Wheezing associated with evidence of allergic sensitisation has been identified as the 'classic' asthma phenotype. Early allergic sensitisation is a major risk factor for persistent asthma... - Characterization of within-subject responses to fluticasone and montelukast in childhood asthmaStanley J Szefler
Department of Pediatrics, National Jewish Medical and Research Medical Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
J Allergy Clin Immunol 115:233-42. 2005..Responses to inhaled corticosteroids (ICSs) and leukotriene receptor antagonists (LTRAs) vary among asthmatic patients... - Systemic responsiveness to lipopolysaccharide and polymorphisms in the toll-like receptor 4 gene in human beingsOlivier Michel
Clinic of Allergology and Respiratory Diseases, CHU Saint Pierre ULB, Brussels, Belgium
J Allergy Clin Immunol 112:923-9. 2003..The response to lipopolysaccharide exposure is highly variable and might be a result of genetic diversity between individuals. The toll-like receptor 4 (TLR-4) is the principal receptor for lipopolysacharide... - Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthmaRobert S Zeiger
Department of Pediatrics, University of California San Diego, San Diego, CA 92111, USA
J Allergy Clin Immunol 117:45-52. 2006..Outcome data are needed to base recommendations for controller asthma medication use in school-aged children... - Single nucleotide polymorphisms in innate immunity genes: abundant variation and potential role in complex human diseaseRoss Lazarus
Channing Laboratory, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Immunol Rev 190:9-25. 2002..These and other factors must be taken into account in the design and analysis of disease association studies... - Polymorphisms in toll-like receptor 4 are not associated with asthma or atopy-related phenotypesBenjamin A Raby
Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 166:1449-56. 2002..Based on these results, we found no evidence that genetic variation in TLR4 contributes to asthma susceptibility... - Tucson Children's Respiratory Study: 1980 to presentLynn M Taussig
National Jewish Medical and Research Center, Denver, USA
J Allergy Clin Immunol 111:661-75; quiz 676. 2003..Future TCRS studies will focus on (1) factors in infancy and early childhood that relate to persistent asthma and atopy; (2) role of genetic factors in persistent asthma; and (3) determinants of lung function decline in early adult life... - Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller TrialChristine A Sorkness
Clinical Science Center, University of Wisconsin, Madison, WI 53792, USA
J Allergy Clin Immunol 119:64-72. 2007..More evidence is needed on which to base recommendations for treatment of mild-moderate persistent asthma in school-aged children... - Toward asthma prevention--does all that really matters happen before we learn to read?Fernando D Martinez
N Engl J Med 349:1473-5. 2003 - Gene-environment interaction effects on the development of immune responses in the 1st year of lifeSabine Hoffjan
Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA
Am J Hum Genet 76:696-704. 2005.... - A polymorphism in CD14 modifies the effect of farm milk consumption on allergic diseases and CD14 gene expressionChristian Bieli
Institute of Social and Preventive Medicine, University of Basel, Basel, Switzerland
J Allergy Clin Immunol 120:1308-15. 2007..Consumption of farm milk in early life is associated with less asthma and allergies... - Association of defensin beta-1 gene polymorphisms with asthmaHara Levy
Children s Hospital, Division of Pulmonary Medicine, Boston, MA, USA
J Allergy Clin Immunol 115:252-8. 2005..Defensins are antimicrobial peptides that may take part in airway inflammation and hyperresponsiveness... - A complete screening of the IL4 gene: novel polymorphisms and their association with asthma and IgE in childhoodMichael Kabesch
University Children s Hospital of Munich, Germany
J Allergy Clin Immunol 112:893-8. 2003..Polymorphism C-589T was reported to influence total serum IgE levels and bronchial hyperresponsiveness. However, no study has investigated the putative existence of further SNPs in exons, introns, and flanking regions of the IL4 gene... - The Faustian bargain of genetic association studies: bigger might not be better, or at least it might not be good enoughDonata Vercelli
J Allergy Clin Immunol 117:1303-5. 2006
Research Grants
- CHROMOSOME 5Q GENE VARIANTS AND ASTHMA-RELATED TRAITSFernando Martinez; Fiscal Year: 2004..This will allow to better understand the genetic influence that determine asthma risk. ..
- LONGITUDINAL STUDY OF ASTHMA FROM BIRTH TO ADULTHOODFernando Martinez; Fiscal Year: 2005....
- IL8 and GATA3-mediated Pathways in Asthma ExacerbationsFernando Martinez; Fiscal Year: 2007..End of Abstract) ..
- CARE Network - Tucson Clinical CenterFernando Martinez; Fiscal Year: 2007..abstract_text> ..
- Natural History of Asthma from Birth to Early Adult LifeFernando Martinez; Fiscal Year: 2007..Elucidating these relations will foster the development of new strategies for the prevention and treatment of asthma and, potentially, of airflow limitation in adult life. ..
- Natural History of Asthma from Birth to Early Adult LifeFernando Martinez; Fiscal Year: 2009..Elucidating these relations will foster the development of new strategies for the prevention and treatment of asthma and, potentially, of airflow limitation in adult life. ..
- Natural History of Asthma from Birth to Early Adult LifeFernando Martinez; Fiscal Year: 2009..Elucidating these relations will foster the development of new strategies for the prevention and treatment of asthma and, potentially, of airflow limitation in adult life. ..
- LONGITUDINAL STUDY OF ASTHMA FROM BIRTH TO ADOLESCENCEFernando Martinez; Fiscal Year: 2000..In the evaluation at age 16 years, symptoms, lung function, including methacholine responsiveness, and atopy and lymphocyte phenotype will be assessed. Various methods for longitudinal data analysis will be employed. ..
- GENETIC REGULATION OF IMMUNE MATURATION IN ASTHMAFernando Martinez; Fiscal Year: 2001....
- INNATE IMMUNITY IN HEART, LUNG, AND BLOOD DISEASEFernando Martinez; Fiscal Year: 2003..abstract_text> ..
- Natural History of Asthma from Birth to Early Adult LifeFernando D Martinez; Fiscal Year: 2010..Elucidating these relations will foster the development of new strategies for the prevention and treatment of asthma and, potentially, of airflow limitation in adult life. ..