Elisabeth D Martinez

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide
    J Chang
    Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 8593, USA
    Br J Cancer 106:116-25. 2012
  2. pmc Identification of four potential epigenetic modulators from the NCI structural diversity library using a cell-based assay
    Anne M Best
    Department of Pharmacology and Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Biomed Biotechnol 2011:868095. 2011
  3. pmc Falling off the academic bandwagon. Women are more likely to quit at the postdoc to principal investigator transition
    Elisabeth D Martinez
    Postdoctoral Fellows Subcommittee, Second Task Force, Status of NIH Intramural Women Scientists, National Institutes of Health, Bethesda, MD, USA
    EMBO Rep 8:977-81. 2007
  4. ncbi Development of assays for nuclear receptor modulators using fluorescently tagged proteins
    Elisabeth D Martinez
    Laboratory of Receptor Biology and Gene Expression, Hormone Action and Oncogenesis Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Methods Enzymol 414:37-50. 2006
  5. pmc A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression
    Ronald L Johnson
    NIH Chemical Genomics Center, National Institutes of Health, Bethesda, MD 20892, USA
    Anal Biochem 375:237-48. 2008
  6. ncbi Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format
    Douglas S Auld
    NIH Chemical Genomics Center, National Institutes of Health, Bethesda, MD 20892, USA
    Methods Enzymol 414:566-89. 2006
  7. pmc Expression profiling of nuclear receptors in the NCI60 cancer cell panel reveals receptor-drug and receptor-gene interactions
    Susan Holbeck
    National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    Mol Endocrinol 24:1287-96. 2010
  8. pmc A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth
    Lei Wang
    Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Nat Commun 4:2035. 2013
  9. pmc Characterizing heterogeneous cellular responses to perturbations
    Michael D Slack
    Department of Pharmacology, Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 105:19306-11. 2008
  10. ncbi High-content fluorescence-based screening for epigenetic modulators
    Elisabeth D Martinez
    Laboratory of Receptor Biology and Gene Expression, Hormone Action and Oncogenesis Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Methods Enzymol 414:21-36. 2006

Detail Information

Publications14

  1. pmc Differential response of cancer cells to HDAC inhibitors trichostatin A and depsipeptide
    J Chang
    Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 8593, USA
    Br J Cancer 106:116-25. 2012
    ....
  2. pmc Identification of four potential epigenetic modulators from the NCI structural diversity library using a cell-based assay
    Anne M Best
    Department of Pharmacology and Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Biomed Biotechnol 2011:868095. 2011
    ..These compounds block the viability of lung cancer and melanoma cells, prevent cell cycle progression, and/or inhibit histone deacetylase activity, altering levels of cellular histone acetylation...
  3. pmc Falling off the academic bandwagon. Women are more likely to quit at the postdoc to principal investigator transition
    Elisabeth D Martinez
    Postdoctoral Fellows Subcommittee, Second Task Force, Status of NIH Intramural Women Scientists, National Institutes of Health, Bethesda, MD, USA
    EMBO Rep 8:977-81. 2007
  4. ncbi Development of assays for nuclear receptor modulators using fluorescently tagged proteins
    Elisabeth D Martinez
    Laboratory of Receptor Biology and Gene Expression, Hormone Action and Oncogenesis Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Methods Enzymol 414:37-50. 2006
    ..This approach has been validated for both the estrogen receptor and the retinoic acid receptor and should be applicable to any member of the superfamily, facilitating the identification of new ligands and selective receptor modulators...
  5. pmc A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression
    Ronald L Johnson
    NIH Chemical Genomics Center, National Institutes of Health, Bethesda, MD 20892, USA
    Anal Biochem 375:237-48. 2008
    ..These results suggest that the identified small molecules act on epigenetic or transcriptional components and validate our approach of using a cell-based imaging assay in conjunction with qHTS...
  6. ncbi Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format
    Douglas S Auld
    NIH Chemical Genomics Center, National Institutes of Health, Bethesda, MD 20892, USA
    Methods Enzymol 414:566-89. 2006
    ..This chapter illustrates the application of microplate laser cytometry to these assays in a manner that is suitable for screening large compound collections in high throughput...
  7. pmc Expression profiling of nuclear receptors in the NCI60 cancer cell panel reveals receptor-drug and receptor-gene interactions
    Susan Holbeck
    National Cancer Institute, National Institutes of Health, Rockville, Maryland 20852, USA
    Mol Endocrinol 24:1287-96. 2010
    ....
  8. pmc A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth
    Lei Wang
    Hamon Center for Therapeutic Oncology Research, UT Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Nat Commun 4:2035. 2013
    ....
  9. pmc Characterizing heterogeneous cellular responses to perturbations
    Michael D Slack
    Department of Pharmacology, Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 105:19306-11. 2008
    ....
  10. ncbi High-content fluorescence-based screening for epigenetic modulators
    Elisabeth D Martinez
    Laboratory of Receptor Biology and Gene Expression, Hormone Action and Oncogenesis Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Methods Enzymol 414:21-36. 2006
    ..Furthermore, options for evaluating the mechanism of action of these compounds are presented and principles to govern the choice of hit compounds for the development of leads are discussed...
  11. ncbi HDAC1 acetylation is linked to progressive modulation of steroid receptor-induced gene transcription
    Yi Qiu
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health, Building 41, B602, Bethesda, Maryland 20892, USA
    Mol Cell 22:669-79. 2006
    ..These findings indicate that HDAC1 is required for the induction of some genes by the GR, and this activator function is dynamically modulated by acetylation...
  12. pmc Anthraquinones from a marine-derived Streptomyces spinoverrucosus
    Youcai Hu
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9038, USA
    J Nat Prod 75:1759-64. 2012
    ..Galvaquinone B (2) was found to show epigenetic modulatory activity at 1.0 μM and exhibited moderate cytotoxicity against non-small-cell lung cancer (NSCLC) cell lines Calu-3 and H2887...
  13. ncbi An estrogen receptor chimera senses ligands by nuclear translocation
    Elisabeth D Martinez
    Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, National Institutes of Health NIH, Bethesda, MD 20892 5055, USA
    J Steroid Biochem Mol Biol 97:307-21. 2005
    ..The translocation properties of this chimera can be utilized in high content screens for novel estrogen receptor modulators...

Research Grants3

  1. Characterization of small molecule inhibitors of HDACs and DNMTs
    Elisabeth Martinez; Fiscal Year: 2007
    ..Using this system, we have already identified eight candidate drugs and propose to characterize them measuring their ability to block the growth of human cancer cells. ..
  2. Characterization of the biological activities of novel epigenetic modulators
    Elisabeth D Martinez; Fiscal Year: 2010
    ..Here, we propose to define how this drug works and to further develop it for therapeutic applications. ..